419:. The US FDA announced the approval of pralatrexate in 2009 for the treatment of relapsed or refractory peripheral T-cell lymphoma (PTCL). Research on drugs of this class began at SRI International in the 1950s. Pralatrexate was first prepared there by Dr. Joseph DeGraw and Dr. William Colwell. Dr. Robert Piper at Southern Research synthesized the key starting material (a bromomethyl compound) which was used to prepare the intermediates needed to make multigram quantities of high purity final compound. Multiple issued patents on this compound are jointly owned by Southern Research, SRI International and Memorial Sloan Kettering and licensed to Allos Therapeutics.
472:, clean air, and clean water. Southern Research develops and tests air and water emissions control technologies for leading utilities, industrial manufacturers, municipal water utilities, and related trade organizations. The division has also historically partnered with private sector firms and government agencies to develop new technologies that transform
116:
Before joining
Southern Research, Carpenter served as director of the Innovation and Economic Opportunity Department for the City of Birmingham, where he led the city's efforts in workforce development, COVID recovery and business expansion. Previously, he worked as the director of External Affairs
84:
15,000 per year for five years, $ 75,000 total, and this was enough for the organization to finance laboratory space and hire researchers and staff. The following year, 1944, the decision was made to change the institute's name from
Alabama Research Institute, to Southern Research Institute.
427:
MLP was founded by the NIH to fund research aimed at identifying new chemical probes against biological targets that might be amenable for drug therapy. Southern
Research was one of eight extramural institutes selected for this initiative along with the
88:
Around this same time, Southern
Research Institute hired its first director, Wilbur Lazier. Though he only stayed in this role for four years, Lazier is credited with recruiting many figures that shaped the history of the organization, including
773:
519:
of
Materials; Electrical, EO/IR, and Mechanical Systems; Hypersonic Structures; Space Structures Characterization; Mechanical Testing of Materials Structures and Components; and Thermal Testing of Materials.
963:
Bonate, Peter L.; Arthaud, Larry; Cantrell, William R.; Stephenson, Katherine; Secrist, John A.; Weitman, Steve (2006). "Discovery and development of clofarabine: a nucleoside analogue for treating cancer".
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246:(CRO), Southern Research provides commercial and government clients with nonclinical and clinical trial support services. They offer studies including both in vitro and in vivo testing of small
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Michael D. Johns is the vice president of
Engineering at Southern Research. He also serves on NASA Space Technology Mission Directorate's Technology, Innovation and Engineering Committee.
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302:. Their current service areas include: High Throughput Screening (HTS), Chemistry, Oncology, Infectious Disease, Neuroscience, and the Center for Neuromolecular Research.
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309:(SOM). The UAB Center for Clinical and Translational Science (CCTS), and the UAB Comprehensive Cancer Center (CCC) are also crucial contributors to the ADDA.
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at the
University of Alabama at Birmingham, as an assistant professor of economics at UAB and as a non-resident senior fellow at The Brookings Institution.
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In 2014, Southern
Research and the University of Alabama at Birmingham formed the Alliance for Innovative Medical Technology (AIMTech) to develop new
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is another anticancer drug whose discovery was a result of contributions from medicinal chemists at
Southern Research along with chemists from
65:
Although Martin was named chairman of the newly chartered organization in
December, 1941, activities were put on hold in the aftermath of the
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research organization that conducts basic and applied research for commercial and non-commercial organizations across four divisions:
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1284:"Southern Research awarded $ 500,000 U.S. Department of Commerce grant to expand medical device innovation and commercialization"
1255:"Southern Research awarded $ 500,000 U.S. Department of Commerce grant to expand medical device innovation and commercialization"
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at the end of 2004 for the treatment of paediatric patients 1–21 years old with relapsed or refractory acute lymphoblastic
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456:. In addition the MLP initiative also included an NIH intramural site: the National Center for Chemical Genomics (NCGC).
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Southern Research celebrated its 75th anniversary in October 2016. In celebration of this milestone the director of
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Southern Research's Drug Development division is the largest of the organization's four divisions. Set up like a
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316:(NAI) in recognition of his wide-ranging contributions to pharmaceutical research and drug discovery efforts.
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1058:"The NIH Molecular Libraries Program: Identifying Chemical Probes for New Medicines | BioScreening.net"
77:, Martin reengaged the Alabama's industrial leaders and received over $ 100,000 in philanthropic donations.
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Mark J. Suto is vice president of Drug Discovery at Southern Research. He has been named a Fellow of the
770:"Cyclenium Pharma and Southern Research Institute Announce Drug Discovery and Development Collaboration"
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Southern Research is a founding member of the Alabama Drug Discovery Alliance (ADDA) along with the
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in more than a decade, and the first to receive approval for paediatric use before adult use.
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after at least two prior regimens. It is the first such drug to be approved for paediatric
8:
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266:. Current service areas include: Bioanalytical Analysis; Anticancer Efficacy Services;
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393:, a second-generation nucleoside analogue received accelerated approval from the US
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849:"Southern Research Institute names Dr. Mark Suto as VP of Drug Discovery Division"
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research program was started in 1946 with a $ 25,000 philanthropic donation from
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752:"NIH director thanks Southern Research for 'treatments, cures and real hope'"
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to hit the market by 2020. By comparison, it can take 10 years to create an
62:, on October 11, 1941, by Thomas Martin as the Alabama Research Institute.
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903:"Drug discovery scientist Mark Suto named to National Academy of Inventors"
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820:"Southern Research: Making Strides in Life-Changing Science for 75 Years"
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is a nucleoside discovered at Southern Research that eventually received
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Southern Research's Drug Discovery division conducts research focused on
47:
73:. Two years later, in December 1943, with a promise of support from the
727:"Southern Research at 75: Discovering cancer drugs and extending lives"
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The organization's scientists are credited with the discovery of seven
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The creation of medical devices are across all five specializations:
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641:"Tom Martin, Alabama Power and the founding of Southern Research"
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grant to expand medical device innovation and commercialization.
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Southern Research's Energy & Environment division focuses on
1172:"How Southern Research helped the program log 542 million miles"
511:
Current areas include: Non destructive evaluation of materials;
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researchers who worked at the institute include Y Fulmer Shealy
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1114:"Southern Research New NASA Contract of Nearly $ 10 million"
1008:"FDA Approval for Pralatrexate - National Cancer Institute"
81:
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258:, and other test articles in therapeutic areas including
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795:"Southern Research contracted for Zika drug discovery"
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University of Alabama at Birmingham School of Medicine
673:"Alabama Power and the founding of Southern Research"
558:. The goal is for the first group of AIMTech-created
379:, John Montgomery, Frank Schabel and Lee Bennett Jr.
662:
1033:"Molecular Libraries Program » Pilot Program"
1346:Medical and health organizations based in Alabama
1336:Medical research institutes in the United States
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1143:"Michael D. Johns Named to Top Engineering Post"
1341:Cancer organizations based in the United States
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569:In 2016, AIMTech was awarded a $ 500,000 U.S.
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502:National Aeronautics and Space Administration
114:named president and CEO of Southern Research.
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343:(FDA) approved anti-cancer drugs, including
80:Alabama Power Company pledged an additional
1197:"U.S. Economic Development Administration"
434:Sanford-Burnham Medical Research Institute
459:
1230:U.S. Economic Development Administration
1201:U.S. Economic Development Administration
932:"Ben May's Gift Launches Cancer Program"
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69:and the beginning of US involvement in
14:
1351:BSL3 laboratories in the United States
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417:Memorial Sloan-Kettering Cancer Center
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1082:Harney, Erin (23 September 2016).
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123:Southern Research Past Presidents
25:
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112:In June 2021, Josh Carpenter was
58:Southern Research was founded in
1112:Beyerle, Dana (11 August 2016).
46:, Energy & Environment, and
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859:from the original on 2018-09-08
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801:from the original on 2017-06-10
797:. Birmingham Business Journal.
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708:from the original on 2019-05-22
683:from the original on 2019-02-16
651:from the original on 2019-02-16
622:from the original on 2016-10-13
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355:developed by Y Fulmer Shealy,
244:contract research organization
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314:National Academy of Inventors
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98:National Institutes of Health
371:(approved in 2009). Notable
341:Food and Drug Administration
7:
1118:Business Council of Alabama
423:Molecular libraries program
221:William M. Murray Jr., PhD
18:Southern Research Institute
10:
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855:. AL.com. 12 August 2011.
576:
526:
442:Scripps Research Institute
53:
702:"Encyclopedia of Alabama"
612:"About Southern Research"
508:and other organizations.
151:John A. Secrist III, PhD
122:
450:University of New Mexico
438:Johns Hopkins University
679:. Alabama News Center.
677:Alabama%20News%20Center
535:to improve healthcare.
211:Howard E. Skipper, PhD
191:John W. Rouse Jr., PhD
571:Department of Commerce
460:Energy and environment
231:Wilbur A. Lazier, PhD
171:J. David Prejean, PhD
141:Arthur J. Tipton, PhD
67:attack on Pearl Harbor
1174:. Southern Research.
1084:"Alabama News Center"
729:. Southern Research.
591:U.S. patent 5,661,136
584:U.S. patent 5,384,310
500:have worked with the
446:Vanderbilt University
75:Alabama Power Company
1149:. The Free Library.
454:University of Kansas
1088:Alabama News Center
936:Alabama News Center
878:"Southern Research"
824:Protective Newsroom
645:Alabama News Center
201:Sabert Oglesby Jr.
161:Robert C. Lonergan
60:Birmingham, Alabama
938:. 3 October 2016.
647:. 7 October 2016.
496:Southern Research
486:water purification
478:chemical synthesis
324:Southern Research
296:infectious disease
272:Infectious Disease
260:infectious disease
1288:Southern Research
756:Southern Research
616:Southern Research
413:SRI International
377:Howard E. Skipper
235:
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181:Gilbert E. Dwyer
91:Howard E. Skipper
28:Southern Research
16:(Redirected from
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510:
504:(NASA), the
495:
476:generation,
470:clean energy
463:
426:
409:Pralatrexate
407:
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369:pralatrexate
338:
323:
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544:Orthopedics
492:Engineering
391:Clofarabine
383:Clofarabine
365:clofarabine
357:fludarabine
353:dacarbazine
250:compounds,
227:1944 - 1948
217:1948 - 1974
207:1974 - 1980
197:1981 - 1987
187:1987 - 1997
177:1997 - 1999
167:1999 - 2000
157:2001 - 2006
147:2006 - 2013
137:2013 – 2019
48:Engineering
1325:Categories
1298:2020-03-04
1269:2020-03-04
1240:2020-03-04
1211:2020-03-04
1182:2020-03-04
1157:2020-03-04
1128:2020-03-04
1098:2020-03-04
1068:2011-03-06
1043:2011-03-06
1018:2009-12-05
946:2020-03-04
917:2020-03-04
888:2020-03-04
863:2020-03-04
834:2020-03-04
805:2020-03-04
780:2020-03-04
737:2020-03-04
712:2020-03-04
687:2020-03-04
655:2020-03-04
626:2016-11-15
598:References
540:Cardiology
466:technology
389:approval.
361:amifostine
345:carmustine
334:Ben E. May
330:Mobile, AL
280:Consulting
268:Immunology
262:, CNS and
108:Leadership
1261:. Yahoo.
1226:"EDA.gov"
513:Chemistry
498:engineers
403:leukaemia
399:leukaemia
349:lomustine
276:Pathology
256:biologics
36:501(c)(3)
1292:Archived
1263:Archived
1234:Archived
1205:Archived
1176:Archived
1151:Archived
1122:Archived
1092:Archived
1062:Archived
1012:Archived
994:21361350
986:17016426
940:Archived
911:Archived
882:Archived
857:Archived
828:Archived
799:Archived
774:Archived
731:Archived
706:Archived
681:Archived
649:Archived
620:Archived
452:and the
292:oncology
252:vaccines
248:molecule
577:Patents
527:AIMTech
517:Physics
100:(NIH),
54:History
992:
984:
853:AL.com
556:Trauma
480:, and
474:energy
373:cancer
326:cancer
298:, and
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