41:
737:
vaccine. According to the CDC, "a study published in the New
England Journal of Medicine indicated that the high-dose vaccine was 24.2% more effective in preventing flu in adults 65 years of age and older relative to a standard-dose vaccine." The CDC recommends the high-dose vaccine for people 65 and over but expresses no preference between it and standard vaccine. Further studies were underway as of 2014.
2287:
2275:
1965:
1848:
1804:
1675:
634:
669:
use, as a 0.5 ml syringe for adults and children, as a 0.5 ml vial for adults and children, and as a 5 ml vial for adults and children. Fluzone must be refrigerated under temperatures from 2 to 8 °C (36 to 46 °F) and is inactivated by freezing. Fluzone was initially approved
736:
A high-dose vaccine (Fluzone High-Dose) four times the strength of standard flu vaccine was approved by the FDA in 2009. This vaccine is intended for people 65 and over, who typically have weakened immune response due to normal aging. The vaccine produces a greater immune response than standard
505:
included in its $ 6.2 billion purchase and the subunit influenza vaccine — Influvac has been commercially available on the market since the early nineteen-eighties. With the acquisition of Solvay, Abbott retained access to the
Eastern European, Middle Eastern & Latin American markets.
1733:
Haugh M, Gresset-Bourgeois V, Macabeo B, Woods A, Samson SI (June 2017). "A trivalent, inactivated influenza vaccine (Vaxigrip): summary of almost 50 years of experience and more than 1.8 billion doses distributed in over 120 countries".
549:
In April 2007, Novartis received a positive opinion supporting
European Union approval of Optaflu. It is the first influenza vaccine made in a mammalian cell line, rather than chicken eggs. The plan was to manufacture the vaccine in
1467:
But
Novartis is building a cell culture flu vaccine factory in Holly Springs, N.C., which might be ready for use in 2010 or 2011. The federal government is providing nearly $ 500 million in construction costs and guaranteed vaccine
753:
made by Sanofi
Pasteur in Europe. Vaxigrip provides immune responses to three influenza strains and VaxigripTetra adds another B strain. VaxigripTetra was approved in Europe in 2016 except for infants younger than three years old.
792:), which subsequently produce the hemagglutinin protein. The protein is harvested and purified. This is done for four different types of influenza hemagglutinin to create the Flublok Quadrivalent vaccine.
2210:
2228:
2246:
561:
in 2014, and was placed under CSL subsidiary, bioCSL (Seqirus). bioCSL as marketing authorization holder decided to discontinue the usage of
Optaflu brand in 2017 due to commercial reasons
1263:
Giezeman KM, Nauta J, de Bruijn IA, Palache AM (April 2009). "Trivalent inactivated subunit influenza vaccine
Influvac: 25-Year experience of safety and immunogenicity".
1505:
311:
1660:
509:
In
February 2015, Mylan Laboratories completed the deal with Abbott to purchase Abbott's generic drugs business in developed markets, which includes Influvac.
661:
Fluzone is typically administered in a single dose by intramuscular injection; an intradermal injection is also available. It is presented as a 0.25 ml
1833:
1616:"Licensure of a high-dose inactivated influenza vaccine for persons aged >or=65 years (Fluzone High-Dose) and guidance for use - United States, 2010"
2200:
2137:
2132:
1567:
1596:
1413:
17:
2247:
List of nationally authorised medicinal products Active substance: influenza vaccine (split virion, inactivated) (non centrally authorised products)
2195:
1192:
778:
technology. This method does not require an egg-grown vaccine virus and does not use chicken eggs in the production process. The DNA for the
1789:
1454:
1950:
339:
2185:
2169:
2153:
1414:"Optaflu, the Novartis cell culture-derived influenza vaccine, receives positive opinion supporting European Union regulatory approval"
1004:
253:
2307:
2229:
List of nationally authorised medicinal products Active substance: influenza vaccine (surface antigen, inactivated, adjuvanted)
1343:
2322:
1033:
Gresset-Bourgeois V, Leventhal PS, Pepin S, Hollingsworth R, Kazek-Duret MP, De Bruijn I, et al. (27 November 2017).
2312:
258:
479:
They contain inactivated purified surface fragments (subunits) from the three different strains of the influenza virus (
1648:
263:
123:
118:
2211:
List of nationally authorised medicinal products Active substance: influenza vaccine (surface antigen, inactivated)
2075:
1987:
1236:
268:
208:
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332:
106:
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84:
62:
554:. The United States government provided $ 500 million in construction costs and guaranteed vaccine purchases.
1821:
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551:
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2017:
1944:
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1783:
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1600:
506:
Approximately $ 850 million of sales revenue from vaccines was reported by Solvay
Pharmaceuticals in 2009.
1421:
2317:
273:
248:
1597:"FDA Approves A High Dose Seasonal Influenza Vaccine Specifically Intended for People Ages 65 and Older"
1320:
2265:
325:
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2236:
2218:
2104:
2046:
1444:
1116:
1087:
1039:
779:
492:
2099:
2011:
835:
obtained
Novartis' flu vaccine unit, and transferred it to CSL Subsidiary, bioCSL, named Seqirus.
827:
Novartis developed the first influenza vaccine, which did not need to be grown in chicken eggs, a
1692:
DiazGranados CA, Dunning AJ, Kimmel M, Kirby D, Treanor J, Collins A, et al. (August 2014).
1111:
1082:
243:
223:
2041:
1777:
1301:
1231:
1140:
495:, on the basis of their latest recommendations. Previously, they were produced and marketed by
306:
296:
198:
2163:
1938:
2147:
1034:
788:
1365:
809:
1599:(Press release). U.S. Food and Drug Administration (FDA). 23 December 2009. Archived from
8:
1533:
805:
750:
646:
574:
535:
496:
417:
136:
693:
In small children and in people with no previous exposure to a flu vaccine, episodes of
1759:
1449:
1064:
828:
687:
375:
359:
include Fluzone/Fluzone Quadrivalent and Vaxigrip/VaxigripTetra, Influvac and Optaflu.
301:
191:
148:
1751:
1715:
1630:
1280:
1056:
1000:
775:
488:
354:
99:
2070:
1068:
50:
1763:
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786:. This recombinant virus is then used to infect cultured insect cells (of the moth
502:
218:
74:
69:
1747:
1276:
1052:
2279:
1571:
767:
457:
421:
79:
57:
40:
1982:
1613:
2291:
2196:"Availability of influenza vaccines by country in EU/EEA in the 2019/20 season"
1887:
650:
601:
2179:
1694:"Efficacy of high-dose versus standard-dose influenza vaccine in older adults"
921:, also marketed as Afluria Quad and Afluria Tetra in various different markets
816:
inactivated vaccines. Flucelvax and its quadrivalent formulations are surface
2301:
1969:
1852:
1808:
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1615:
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372:
213:
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450:
413:
379:
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203:
168:
158:
153:
1366:"Pfizer Completes Transaction to Combine Its Upjohn Business with Mylan"
1506:"Optaflu - Expiry of the marketing authorisation in the European Union"
905:
717:
291:
173:
143:
963:
666:
178:
163:
111:
32:
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236:
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1968:
This article incorporates text from this source, which is in the
1851:
This article incorporates text from this source, which is in the
1807:
This article incorporates text from this source, which is in the
1678:
This article incorporates text from this source, which is in the
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813:
709:
702:
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662:
532:
513:
454:
1321:"Mylan to buy Abbott generics, cut taxes, in $ 5.3 billion deal"
1028:
1026:
1024:
1022:
1614:
Centers for Disease Control and Prevention (CDC) (April 2010).
1001:"Influenza vaccines — United States, 2019–20 influenza season*"
721:
578:
480:
1983:"Fluad Quad Australian prescription medicine decision summary"
1691:
1484:"Australia's CSL buys Novartis flu vaccine unit for $ 275 mln"
1262:
1193:"GSK ships 2019-20 seasonal influenza vaccines for US market"
1019:
713:
694:
461:
2286:
1035:"Quadrivalent inactivated influenza vaccine (VaxigripTetra)"
501:
In February 2010, Abbott acquired the vaccines subunit from
683:
1583:
633:
2263:
838:
The following are list of bioCSL flu vaccine brands:
774:. Recombinant influenza vaccines are produced using
1445:"Swine Flu Vaccine May Be Months Away, Experts Say"
2201:European Centre for Disease Prevention and Control
2138:European Centre for Disease Prevention and Control
678:The following adverse effects have been reported:
516:after Upjohn merged with Mylan to create Viatris.
2299:
1406:
1478:
1476:
757:
808:. Fluad and its quadrivalent formulations are
1867:"FDA Clinical Review of Flublok Quadrivalent"
333:
1726:
1685:
1473:
708:In people who are sensitive to egg protein,
1623:MMWR. Morbidity and Mortality Weekly Report
1436:
749:formulation Vaxigrip Tetra are split virus
512:In some countries, Influvac is marketed by
491:) that are selected and distributed by the
2186:Centers for Disease Control and Prevention
2170:Centers for Disease Control and Prevention
2154:Centers for Disease Control and Prevention
1885:
1528:
1526:
1341:
1258:
1256:
1226:
1224:
1222:
1220:
1218:
1216:
1214:
1005:Centers for Disease Control and Prevention
740:
340:
326:
1879:
1709:
1538:Center for Disease Control and Prevention
1296:
1294:
995:
993:
991:
989:
987:
985:
782:antigen of influenza virus is added to a
1864:
1511:. European Medicine Agency. 22 June 2017
632:
1523:
1442:
1318:
1253:
1211:
557:Novartis' flu vaccine unit was sold to
14:
2300:
1888:"This Flu Shot Is Not Like the Others"
1291:
982:
2164:"Upcoming 2019-2020 Influenza Season"
2133:"Types of seasonal influenza vaccine"
1584:"Fluzone intradermal vaccine website"
1560:
1558:
1556:
1554:
1534:"Recombinant Influenza (Flu) Vaccine"
656:
1953:from the original on 2 December 2019
1836:from the original on 14 October 2019
1792:from the original on 14 October 2019
1663:from the original on 1 December 2019
1457:from the original on 24 January 2020
731:
24:
1551:
1232:"2021 seasonal influenza vaccines"
673:
407:
25:
2339:
2148:"Different Types of Flu Vaccines"
2125:
1565:"Fluzone Prescribing Information"
1342:Tascarella P (27 February 2015).
1171:U.S. Food and Drug Administration
1145:U.S. Food and Drug Administration
820:inactivated vaccines prepared in
604:produces the following vaccines:
596:
569:Vaxigrip Tetra and Fluquadri are
564:
18:Seasonal influenza vaccine brands
2285:
2273:
2076:Therapeutic Goods Administration
1988:Therapeutic Goods Administration
1963:
1846:
1802:
1788:. 26 February 2018. STN 125285.
1673:
1649:"Fluzone High-Dose Quadrivalent"
1344:"Mylan inversion deal completed"
1306:Drug Discovery & Development
1237:Therapeutic Goods Administration
444:
269:2015 United States H5N2 outbreak
39:
2092:
2063:
2034:
2004:
1975:
1949:. 8 November 2019. STN 125510.
1931:
1905:
1858:
1814:
1770:
1641:
1607:
1589:
1577:
1498:
1380:
1358:
1335:
1312:
2308:Drugs developed by AstraZeneca
1886:Alice Park (30 October 2014).
1185:
1159:
1133:
1104:
1075:
804:formulation are a split virus
362:
13:
1:
1832:. 2 August 2019. STN 125285.
1748:10.1080/14760584.2017.1324302
1277:10.1016/j.vaccine.2009.02.008
1053:10.1080/14760584.2018.1407650
975:
690:at the local of the injection
653:mainly in the United States.
552:Holly Springs, North Carolina
416:formulations are split virus
2018:Food and Drug Administration
1945:Food and Drug Administration
1872:Food and Drug Administration
1828:Food and Drug Administration
1784:Food and Drug Administration
1655:Food and Drug Administration
1574:. Sanofi Pasteur. June 2012.
1302:"Abbott Halts Influvac Sale"
888:in various different markets
862:in various different markets
768:recombinant subunit vaccines
758:Flublok/Flublok Quadrivalent
645:formulation are split virus
412:Fluarix, Flulaval and their
7:
2323:Drugs developed by Novartis
1865:Nolletti C (11 July 2016).
1443:Pollack A (28 April 2009).
1346:. Pittsburgh Business Times
957:
519:
124:Seasonal flu vaccine brands
10:
2344:
2313:Drugs developed by GSK plc
1486:. Reuters. 27 October 2014
1376:– via Business Wire.
1368:. Pfizer. 16 November 2020
1319:Pierson R (14 July 2014).
795:
628:
367:Fluenz, FluMist and their
259:2007 Bernard Matthews H5N1
2255:European Medicines Agency
2237:European Medicines Agency
2219:European Medicines Agency
2105:European Medicines Agency
2047:European Medicines Agency
1117:European Medicines Agency
1088:European Medicines Agency
1040:Expert Review of Vaccines
493:World Health Organization
966:, a pandemic flu vaccine
453:formulation are surface
741:Vaxigrip/Vaxigrip Tetra
274:2020–2022 H5N8 outbreak
2100:"Flucelvax Tetra EPAR"
1822:"Flublok Quadrivalent"
1167:"FluMist Quadrivalent"
945:Flucelvax Quadrivalent
638:
503:Solvay Pharmaceuticals
312:Vaccine reformulations
307:Influenza-like illness
254:2007 Australian equine
1711:10.1056/NEJMoa1315727
1007:(CDC). 22 August 2019
789:Spodoptera frugiperda
682:Mild soreness, local
637:A 5cc vial of Fluzone
636:
199:1889-1890 Russian flu
2012:"Fluad Quadrivalent"
1913:"CSL's product list"
1659:. 14 November 2019.
1603:on 31 December 2009.
1570:10 June 2015 at the
919:Afluria Quadrivalent
806:inactivated vaccines
751:inactivated vaccines
670:in 1980 by the FDA.
647:inactivated vaccines
575:inactivated vaccines
418:inactivated vaccines
402:FluMist Quadrivalent
2180:"Seasonal Flu Shot"
2142:. 19 December 2017.
2109:. 24 September 2018
1736:Expert Rev Vaccines
1424:on 21 November 2008
1112:"Fluenz Tetra EPAR"
894:, also marketed as
868:, also marketed as
850:, also marketed as
712:may ensue, such as
536:inactivated vaccine
497:Abbott Laboratories
376:attenuated vaccines
297:Influenza evolution
209:1957-1958 Asian flu
2318:Influenza vaccines
2205:. 11 October 2019.
2080:. 9 September 2020
2042:"Fluad Tetra EPAR"
2022:. 21 February 2020
1992:. 13 December 2019
1450:The New York Times
1394:. 16 November 2020
1121:. 17 December 2013
1092:. 17 December 2013
930:Fluad Quadrivalent
829:cell-based vaccine
710:allergic reactions
657:Dosage and storage
639:
302:Influenza research
214:1968 Hong Kong flu
149:Baloxavir marboxil
1586:. Sanofi Pasteur.
1416:(Press release).
776:recombinant virus
745:Vaxigrip and its
732:High-dose vaccine
489:Influenza B virus
449:Influvac and its
371:formulations are
355:influenza vaccine
350:
349:
16:(Redirected from
2335:
2328:Subunit vaccines
2290:
2289:
2278:
2277:
2276:
2269:
2260:
2251:
2242:
2233:
2224:
2215:
2206:
2191:
2190:. 12 March 2024.
2175:
2159:
2158:. 14 March 2024.
2143:
2119:
2118:
2116:
2114:
2096:
2090:
2089:
2087:
2085:
2071:"Flucelvax Quad"
2067:
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2008:
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1493:
1491:
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1471:
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1440:
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1433:
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1429:
1420:. Archived from
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1099:
1097:
1079:
1073:
1072:
1030:
1017:
1016:
1014:
1012:
997:
800:Afluria and its
766:formulation are
762:Flublok and its
641:Fluzone and its
542:manufactured by
458:subunit vaccines
342:
335:
328:
264:2008 West Bengal
219:1977 Russian flu
204:1918 Spanish flu
43:
29:
28:
21:
2343:
2342:
2338:
2337:
2336:
2334:
2333:
2332:
2298:
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2112:
2110:
2098:
2097:
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2083:
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2069:
2068:
2064:
2054:
2052:
2051:. 24 March 2020
2040:
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2010:
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1995:
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1698:N. Engl. J. Med
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1572:Wayback Machine
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1242:
1241:. 13 April 2021
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1197:GlaxoSmithKline
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998:
983:
978:
960:
950:Flucelvax Tetra
902:Fluad Pediatric
798:
760:
743:
734:
676:
674:Adverse effects
659:
649:distributed by
631:
599:
567:
522:
447:
422:GlaxoSmithKline
410:
408:GlaxoSmithKline
365:
346:
317:
316:
287:
279:
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249:2006 H5N1 India
239:
229:
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194:
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139:
129:
128:
119:Live attenuated
102:
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53:
33:Influenza (flu)
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2126:External links
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2003:
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1742:(6): 545–564.
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1271:(18): 2414–7.
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940:Flucelvax Quad
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651:Sanofi Pasteur
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618:Vaxigrip Tetra
611:
602:Sanofi Pasteur
598:
597:Sanofi Pasteur
595:
594:
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588:
586:Vaxigrip Tetra
579:Sanofi-Aventis
566:
565:Sanofi-Aventis
563:
521:
518:
477:
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474:Influvac Tetra
471:
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1147:. 9 July 2020
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1083:"Fluenz EPAR"
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2111:. Retrieved
2103:
2094:
2084:22 September
2082:. Retrieved
2074:
2065:
2053:. Retrieved
2045:
2036:
2024:. Retrieved
2015:
2006:
1994:. Retrieved
1986:
1977:
1955:. Retrieved
1942:
1933:
1921:. Retrieved
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1816:
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1687:
1665:. Retrieved
1652:
1643:
1626:
1622:
1609:
1601:the original
1591:
1579:
1541:. Retrieved
1537:
1513:. Retrieved
1500:
1488:. Retrieved
1466:
1459:. Retrieved
1448:
1438:
1426:. Retrieved
1422:the original
1408:
1396:. Retrieved
1391:
1382:
1370:. Retrieved
1360:
1348:. Retrieved
1337:
1325:. Retrieved
1314:
1268:
1264:
1243:. Retrieved
1235:
1201:. Retrieved
1196:
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1175:. Retrieved
1170:
1161:
1149:. Retrieved
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1135:
1123:. Retrieved
1115:
1106:
1094:. Retrieved
1086:
1077:
1044:
1038:
1009:. Retrieved
970:H5N1 vaccine
949:
944:
939:
934:
929:
924:
918:
914:Quadrivalent
901:
895:
891:
885:
881:
877:
873:
869:
865:
859:
855:
851:
847:
837:
826:
802:quadrivalent
799:
787:
770:prepared in
764:quadrivalent
761:
747:quadrivalent
744:
735:
677:
660:
643:quadrivalent
640:
622:
617:
613:
608:
600:
590:
585:
573:split virus
571:quadrivalent
568:
556:
548:
538:prepared in
524:
523:
511:
508:
500:
478:
473:
468:
460:marketed by
451:quadrivalent
448:
438:
433:
428:
414:quadrivalent
411:
401:
396:
392:Fluenz Tetra
391:
386:
369:quadrivalent
366:
352:
351:
26:
1917:seqirus.com
1667:30 November
1047:(1): 1–11.
935:Fluad Tetra
833:CSL Limited
831:. In 2014,
784:baculovirus
726:anaphylaxis
559:CSL Limited
380:AstraZeneca
363:AstraZeneca
169:Rimantadine
159:Oseltamivir
154:Laninamivir
2302:Categories
1957:2 December
1923:27 January
1897:19 October
1840:14 October
1796:14 October
1543:4 February
1515:27 January
1490:27 January
1468:purchases.
1350:27 January
1327:27 January
1203:27 January
1011:27 January
976:References
925:Fluad Quad
810:adjuvanted
718:angioedema
292:Flu season
174:Umifenovir
144:Amantadine
2259:(Report).
2241:(Report).
2223:(Report).
1996:24 August
1919:. Seqirus
1778:"Flublok"
1323:. reuters
1141:"FluMist"
964:Pandemrix
906:pediatric
843:Trivalent
667:pediatric
591:Fluquadri
529:trivalent
353:Seasonal
237:Outbreaks
192:Pandemics
179:Zanamivir
164:Peramivir
137:Treatment
112:Pandemrix
2280:Medicine
2113:31 March
1951:Archived
1834:Archived
1790:Archived
1756:28460594
1720:25119609
1661:Archived
1635:20431524
1568:Archived
1461:29 April
1455:Archived
1428:29 April
1418:Novartis
1388:"Brands"
1285:19368782
1245:15 April
1177:6 August
1151:6 August
1125:6 August
1096:6 August
1069:23761150
1061:29157068
958:See also
898:in Spain
896:Chiromas
886:Chiroflu
878:Sandovac
870:Begripal
866:Agrippal
812:surface
688:swelling
614:Vaxigrip
544:Novartis
531:surface
520:Novartis
469:Influvac
434:Flulaval
286:See also
100:Vaccines
2292:Viruses
2266:Portals
1939:"Fluad"
1764:3353358
1398:17 June
1392:Viatris
1372:17 June
1265:Vaccine
1003:. U.S.
908:vaccine
882:Agriflu
874:Fluazur
860:Nilgrip
848:Afluria
818:antigen
814:antigen
796:Seqirus
703:myalgia
699:malaise
663:syringe
629:Fluzone
623:Flublok
609:Fluzone
533:antigen
525:Optaflu
514:Viatris
455:antigen
429:Fluarix
397:FluMist
2203:(ECDC)
2140:(ECDC)
2055:29 May
2026:29 May
1762:
1754:
1718:
1633:
1283:
1067:
1059:
884:, and
858:, and
856:Fluvax
852:Enzira
722:asthma
487:, and
485:A/H3N2
481:A/H1N1
387:Fluenz
357:brands
75:Equine
70:Canine
2257:(EMA)
2250:(PDF)
2239:(EMA)
2232:(PDF)
2221:(EMA)
2214:(PDF)
2188:(CDC)
2184:U.S.
2172:(CDC)
2168:U.S.
2156:(CDC)
2152:U.S.
2107:(EMA)
2078:(TGA)
2049:(EMA)
2020:(FDA)
2016:U.S.
1990:(TGA)
1947:(FDA)
1943:U.S.
1830:(FDA)
1826:U.S.
1786:(FDA)
1782:U.S.
1760:S2CID
1657:(FDA)
1653:U.S.
1619:(PDF)
1509:(PDF)
1239:(TGA)
1119:(EMA)
1090:(EMA)
1065:S2CID
892:Fluad
714:hives
695:fever
527:is a
462:Mylan
373:nasal
80:Swine
58:Avian
51:Types
2115:2020
2086:2020
2057:2020
2028:2020
1998:2020
1959:2019
1925:2020
1899:2021
1892:Time
1842:2019
1798:2019
1752:PMID
1716:PMID
1669:2019
1631:PMID
1545:2020
1517:2020
1492:2020
1463:2009
1430:2009
1400:2024
1374:2024
1352:2020
1329:2020
1281:PMID
1247:2021
1205:2020
1179:2020
1153:2020
1127:2020
1098:2020
1057:PMID
1013:2020
904:, a
724:and
686:and
684:pain
665:for
1744:doi
1706:doi
1702:371
1273:doi
1049:doi
577:by
420:by
378:by
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2014:.
1985:.
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