467:
957:
marboxil or a single dose of a placebo. Of these 607 subjects, 303 received baloxavir marboxil and 304 received the placebo. The trial's primary endpoint was the proportion of subjects who were infected with influenza virus and presented with fever and at least one respiratory symptom from day 1 to day 10. Of those who received baloxavir marboxil, 1% of subjects met these criteria, compared to 13% of subjects who received a placebo for the clinical trial.
31:
1904:
1942:
834:
3333:
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929:(FDA) approved baloxavir marboxil based on evidence of its benefits and side effects from two clinical trials in adult and pediatric participants with uncomplicated influenza (Trial 1, 1518T0821 and Trial 2, NCT02954354), involving 1119 participants. Both trials included clinical sites and participants in Japan, with Trial 2 adding clinical locations in the United States.
953:
hours of experiencing flu symptoms. In both trials, subjects treated with baloxavir marboxil had a shorter time to alleviation of symptoms compared with subjects who took the placebo. In the second trial, there was no difference in the time to alleviation of symptoms between subjects who received baloxavir marboxil and those who received the other flu treatment.
1923:
956:
The safety and efficacy of baloxavir marboxil for post-flu exposure prevention is supported by one randomized, double-blind, controlled trial in which 607 subjects, twelve years of age and older who were exposed to a person with influenza in their household, received either a single dose of baloxavir
1961:
952:
The safety and efficacy of baloxavir marboxil, an antiviral drug taken as a single oral dose, was demonstrated in two randomized controlled clinical trials of 1,832 subjects where participants were assigned to receive either baloxavir marboxil, a placebo, or another antiviral flu treatment within 48
945:
for the treatment of acute, uncomplicated influenza in people twelve years of age and older at risk of influenza complications. In
November 2020, the FDA approved an updated indication to include post-exposure prevention of influenza (flu) for people twelve years of age and older after contact with
932:
Baloxavir marboxil was approved for sale in Japan in
February 2018. In October 2018, the FDA approved it for the treatment of acute uncomplicated influenza in people twelve years of age and older who have been symptomatic for no more than 48 hours. The FDA application of baloxavir marboxil was
885:
decreased more than in participants in either the oseltamivir or placebo groups; however, after five days, the effect on viral load of the single dose of baloxavir was indistinguishable from the effect observed following the complete, 5-day regimen of oseltamivir in its treatment group.
742:
to the drug, due to variants of the polymerase protein displaying substitutions of isoleucine-38, specifically, the I38T, I38M, or I38F mutations. There is continuing research into and clinical concern over the resistance appearing in recipients, in response to treatment with this drug.
760:
Common side effects following the single dose administration of baloxavir marboxil include diarrhea, bronchitis, common cold, headache, and nausea. Adverse events were reported in 21% of people who received baloxavir, 25% of those receiving placebo, and 25% of oseltamivir.
876:
As of
September 2018, in the only report of a Phase III randomized, controlled trial, baloxavir reduced the duration of influenza symptoms of otherwise healthy participants by about one day compared with a placebo treatment group, and comparable with what was seen for an
1741:
Imai M, Yamashita M, Sakai-Tagawa Y, Iwatsuki-Horimoto K, Kiso M, Murakami J, et al. (January 2020). "Influenza A variants with reduced susceptibility to baloxavir isolated from
Japanese patients are fit and transmit through respiratory droplets".
1902:, Kawai M, Tomita K, Akiyama T, Okano A, Miyagawa M, "Pharmaceutical composition containing polycyclic pyridone derivatives as cap-dependent endonuclease (CEN) inhibitors.", published 2017, assigned to Shionogi and Co., Ltd., Japan.
549:
1940:, Kawai M, Tomita K, Akiyama T, Okano A, Miyagawa M, "Preparation of polycyclic pyridone derivatives as cap-dependent endonuclease (CEN) inhibitors and prodrugs thereof.", published 2016, assigned to Shionogi and Co., Ltd., Japan
855:
in cells of the blood, liver, and lumen of the small intestine. The compound numbers for baloxavir marboxil and baloxavir acid used in publications by
Shionogi and others during discovery and development (prior to assignment of a
1605:
829:
and Co. of Japan (as well as others); the
Shionogi reports have appeared several times in the Japanese patent literature between 2016 and 2019, providing insight into possible industrial synthetic routes that may be in use.
1883:, Okamoto K, Ueno T, Hato Y, Hakogi T, Majima S, "Method for stereoselective preparation of substituted polycyclic pyridone derivative.", published 2019, assigned to Shionogi & Co., Ltd., Japan.
705:, for individuals who are twelve years of age or older, that have presented symptoms of this infection for no more than 48 hours. The efficacy of baloxavir marboxil administered after 48 hours has not been tested.
941:& Co., Ltd. in October 2018. Specifically, the FDA approved the use of baloxavir marboxil for people at high risk of developing influenza-related complications. In October 2019, the FDA approved an updated
751:
Baloxavir marboxil should not be co-administered with dairy products, calcium-fortified beverages, or laxatives, antacids, or oral supplements containing calcium, iron, magnesium, selenium, aluminum or zinc.
1689:
715:
In
November 2020, the FDA approved an updated indication to include post-exposure prevention of influenza (flu) for people twelve years of age and older after contact with an individual who has the flu.
719:
In August 2022, the FDA approved an updated indication to include post-exposure prevention of influenza (flu) for people five years of age and older after contact with an individual who has the flu.
2288:
1439:
591:
InChI=1S/C27H23F2N3O7S/c1-36-27(35)39-14-38-25-19(33)8-9-31-24(25)26(34)30-10-11-37-12-21(30)32(31)23-15-6-7-18(28)22(29)17(15)13-40-20-5-3-2-4-16(20)23/h2-9,21,23H,10-14H2,1H3/t21-,23+/m1/s1
1601:
722:
In the EU, baloxavir marboxil is indicated for the treatment of uncomplicated influenza and for post-exposure prophylaxis of influenza in individuals aged twelve years of age and older.
1921:, Shibahara S, Fukui N, Maki T, "Polycyclic pyridone derivative, crystal and preparation method thereof.", published 2017, assigned to Shionogi and Co., Ltd., Japan.
242:
2742:
2737:
146:
1055:
864:(carbonate) moiety of the prodrug—shown in the lower left-hand corner of the image above—was prepared during discovery and development research from a late stage 2-hydroxy-
1104:
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In 2.2% of baloxavir recipients in the Phase II trial and in about 10% of baloxavir recipients in the Phase III trial, the infecting influenza strain had
2897:
1308:
1431:
1023:
2041:"Molecular Dynamics Simulation reveals the mechanism by which the Influenza Cap-dependent Endonuclease acquires resistance against Baloxavir marboxil"
2318:
3138:
1375:"In vitro characterization of baloxavir acid, a first-in-class cap-dependent endonuclease inhibitor of the influenza virus polymerase PA subunit"
1959:, Zhu X, Jiang W, "Process for preparation of substituted polycyclic carbamoylpyridone derivative and its prodrug.", published 2018
1159:
Text was copied from this source which is copyright
European Medicines Agency. Reproduction is authorized provided the source is acknowledged.
3378:
908:. The names under which baloxavir marboxil and baloxavir acid appear in Shionogi research reporting are S-033188 and S-033447, respectively.
61:
2004:
Hughes DL (June 2019). "Review of the Patent
Literature: Synthesis and Final Forms of Antiviral Drugs Tecovirimat and Baloxavir Marboxil".
1719:
563:
2341:"Genentech Announces FDA Approval of Xofluza (Baloxavir Marboxil) for People at High Risk of Developing Influenza-Related Complications"
625:. It may reduce the duration of flu symptoms by about a day, but is prone to selection of resistant mutants that render it ineffectual.
2227:
1146:
1045:
2348:
3187:
1529:
2463:
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for the treatment of acute, uncomplicated influenza in people twelve years of age and older at risk of influenza complications.
3293:
922:
129:
3383:
3298:
2257:
2250:"A Study of S-033188 (Baloxavir Marboxil) Compared With Placebo or Oseltamivir in Otherwise Healthy Patients With Influenza"
1207:
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2732:
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1252:
296:
227:
93:
621:. It was approved for medical use both in Japan and in the United States in 2018, and is taken as a single dose
3393:
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2622:
2617:
2311:"Xofluza (Baloxavir Marboxil) Tablets 10mg/20mg Approved For The Treatment Of Influenza Types A And B In Japan"
781:
activity, one of the activities of the virus polymerase complex. In particular, it inhibits a process known as
739:
2100:"Evaluation of Drug-Drug Interaction Potential between Baloxavir Marboxil and Oseltamivir in Healthy Subjects"
1297:
1015:
3408:
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1937:
1918:
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1435:
1304:
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1211:
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from host cell RNA transcripts, which it then uses for polymerase-catalyzed synthesis of its needed viral
2926:
2844:
2829:
2310:
2139:
Yang J, Huang Y, Liu S (May 2019). "Investigational antiviral therapies for the treatment of influenza".
1880:
860:(USAN)) were, respectively, S-033188 and S-033447. As reported in a review of the patent literature, the
446:
1956:
3311:
857:
786:
881:
treatment group. On the first day after baloxavir was started in its treatment group of participants,
825:
family, whose chemical synthesis has been reported in a number of ways by the company discovering it,
3368:
3272:
2887:
1140:
690:
462:
107:
2451:
1711:
3363:
844:
Baloxavir marboxil (BXM) is a prodrug whose active agent, baloxavir acid (BXA) is released rapidly
798:
797:
activity catalyzes its cleavage "after 10–13 nucleotides". As such, its mechanism is distinct from
3229:
3115:
3085:
3080:
2974:
2779:
2501:
183:
43:
1602:"Genentech Announces FDA Approval of Xofluza to Treat Influenza in Children Aged Five and Older"
3288:
3090:
2892:
2860:
2795:
1837:
O'Hanlon R, Shaw ML (April 2019). "Baloxavir marboxil: the new influenza drug on the market".
395:
3418:
3373:
2870:
2374:
Ikematsu H, Hayden FG, Kawaguchi K, Kinoshita M, de Jong MD, Lee N, et al. (July 2020).
1682:"Roche's flu med Xofluza drives drug resistance and may be a bad choice for kids, study says"
942:
709:
330:
2216:
1135:
3413:
3398:
2880:
2340:
2052:
793:. A polymerase subunit binds to the host pre-mRNAs at their 5' caps, then the polymerase's
415:
1632:
Hayden FG, Sugaya N, Hirotsu N, Lee N, de Jong MD, Hurt AC, et al. (September 2018).
1521:
1373:
Noshi T, Kitano M, Taniguchi K, Yamamoto A, Omoto S, Baba K, et al. (December 2018).
466:
71:
8:
2940:
2824:
2541:
861:
822:
622:
321:
190:
2056:
1344:"Baloxavir Marboxil for Uncomplicated Influenza: Mechanism of Action & Side Effects"
3072:
2761:
2531:
2494:
2471:
2217:"A flu drug — shown to reduce the duration of symptoms — could upend treatment in U.S."
2164:
2075:
2021:
1862:
1811:
1786:
1767:
1663:
960:
Baloxavir marboxil was approved for medical use in the
European Union in January 2021.
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2410:
1975:
355:
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85:
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Baloxavir marboxil is available in tablet form and as granules for mixing in water.
3237:
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2774:
2597:
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2013:
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210:
22:
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1936:
1898:
1850:
934:
3337:
2949:
2556:
2222:
2065:
2040:
949:
Baloxavir marboxil was approved for medical use in Australia in February 2020.
897:
774:
641:
2116:
2099:
1755:
3347:
3242:
3105:
2017:
1879:
1588:
1501:
1458:
1343:
1330:
1279:
1234:
1050:
982:
838:
782:
649:
571:
O=C(OCOC(C(C=C1)=O)=C(N1N(2C3=CC=CC=C3SCC4=C(F)C(F)=CC=C24)5()N6CCOC5)C6=O)OC
2376:"Baloxavir Marboxil for Prophylaxis against Influenza in Household Contacts"
1471:
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2551:
2436:
2401:
2160:
2125:
2084:
1858:
1820:
1763:
1659:
1400:
794:
778:
645:
205:
2392:
2375:
1740:
1650:
1634:"Baloxavir Marboxil for Uncomplicated Influenza in Adults and Adolescents"
1633:
3257:
2984:
2979:
2967:
2769:
1432:"FDA Expands Approval of Influenza Treatment to Post-Exposure Prevention"
1253:"Drug Approval Package: Xofluza Film-Coated Tablets (Baloxavir marboxil)"
901:
878:
852:
802:
79:
1802:
375:
3215:
3133:
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2957:
2561:
882:
865:
769:
Baloxavir marboxil is an influenza therapeutic agent, specifically, an
667:
656:
525:
386:
111:
3267:
3262:
3042:
3001:
2994:
2989:
2517:
2344:
806:
702:
675:
341:
65:
30:
2314:
938:
890:
826:
818:
679:
663:
435:
366:
124:
2098:
Kawaguchi N, Koshimichi H, Ishibashi T, Wajima T (November 2018).
2097:
548:
3177:
1587:
This article incorporates text from this source, which is in the
1528:. American Society of Health-System Pharmacists. 19 August 2019.
1500:
This article incorporates text from this source, which is in the
1457:
This article incorporates text from this source, which is in the
1329:
This article incorporates text from this source, which is in the
1278:
This article incorporates text from this source, which is in the
1233:
This article incorporates text from this source, which is in the
629:
2373:
3047:
671:
3247:
937:
in the United States, and approval of Xofluza was granted to
894:
849:
539:
3332:
2486:
1917:
1559:
1372:
833:
451:
983:"Xofluza Australian prescription medicine decision summary"
868:
precursor by treatment with chloromethyl methyl carbonate.
790:
662:
The most common side effects of baloxavir marboxil include
426:
1712:"New flu drug drives drug resistance in influenza viruses"
848:, as the hydrolysis of baloxavir marboxil is catalyzed by
632:
strategy, with its metabolism releasing the active agent,
2281:"One-dose flu drug Xofluza gets nod from health ministry"
308:)-12-thiepin-11-yl]-6,8-dioxo-3,4,6,8,12,12a-hexahydro-1
312:-oxazinopyrido triazin-7-yl}oxy)methyl methyl carbonate
1631:
3309:
1787:"At the centre: influenza A virus ribonucleoproteins"
1784:
2411:"Baloxavir: game-changer or much ado about nothing?"
2038:
1292:
1290:
1288:
1247:
1245:
1243:
1091:
1089:
1087:
1085:
1083:
1081:
1079:
1077:
1075:
1073:
889:Baloxavir marboxil was developed for the market by
2215:
2182:
1982:. U.S. National Library of Medicine. CID 124081876
1426:
1424:
1422:
1420:
1418:
1416:
1414:
1412:
1410:
701:Baloxavir marboxil is an influenza medication, an
1999:
1997:
1785:Eisfeld AJ, Neumann G, Kawaoka Y (January 2015).
1202:
1200:
1198:
1196:
1194:
1192:
1190:
1097:"Xofluza- baloxavir marboxil tablet, film coated"
3345:
2039:Yoshino R, Yasuo N, Sekijima M (November 2019).
1836:
1522:"Baloxavir Marboxil Monograph for Professionals"
1285:
1240:
1070:
659:complex, a process essential to its life-cycle.
354:
1555:
1553:
1551:
1549:
1547:
1407:
977:
975:
973:
329:
1994:
1955:
1832:
1830:
1187:
1130:
1128:
1126:
1124:
1122:
837:Baloxavir acid (BXA) or simply baloxavir, the
613:, is an antiviral medication for treatment of
141:
2502:
1560:Food and Drug Administration (23 July 2019).
1046:"Summary Basis of Decision (SBD) for Xofluza"
708:In October 2019, the FDA approved an updated
2138:
1604:(Press release). Genentech. 11 August 2022.
1544:
970:
128:
1827:
1516:
1514:
1512:
1510:
1119:
785:, by which the virus derives short, capped
689:(FDA) considers baloxavir marboxil to be a
280:In general: ℞ (Prescription only)
2509:
2495:
2006:Organic Process Research & Development
1298:"FDA Approval Package for 210854Orig1s001"
1208:"FDA approves new drug to treat influenza"
465:
394:
2426:
2391:
2213:
2115:
2074:
2064:
1810:
1649:
1390:
414:
1507:
832:
636:(BXA). Baloxavir acid then functions as
2408:
2141:Expert Opinion on Investigational Drugs
1627:
1625:
1623:
461:
374:
84:
3346:
2003:
1485:from the original on 17 September 2020
923:Ministry of Health, Labour and Welfare
911:
764:
628:Baloxavir marboxil was developed as a
272:
102:
3299:US influenza statistics by flu season
2490:
2278:
1692:from the original on 25 November 2020
1572:from the original on 12 December 2019
1442:from the original on 23 November 2020
1354:from the original on 24 February 2021
260:
136:
119:
70:
3379:Drugs developed by Hoffmann-La Roche
2458:. U.S. National Library of Medicine.
2351:from the original on 24 October 2019
2321:from the original on 20 January 2021
2291:from the original on 2 November 2021
2260:from the original on 21 January 2022
2230:from the original on 20 October 2020
2207:
1722:from the original on 16 January 2021
1620:
1218:from the original on 24 October 2019
1174:Union Register of medicinal products
1149:from the original on 30 January 2021
1107:from the original on 28 October 2020
817:Baloxavir marboxil is a substituted
746:
209:
1608:from the original on 12 August 2022
1532:from the original on 7 October 2019
1026:from the original on 12 August 2022
434:
345:
13:
3294:2017–2018 United States flu season
2367:
996:from the original on 13 March 2020
725:
14:
3430:
3033:Live attenuated influenza vaccine
2468:SPS - Specialist Pharmacy Service
2444:
2195:from the original on 26 July 2020
1314:from the original on 9 April 2021
1263:from the original on 26 July 2020
640:, targeting the influenza virus'
236:
168:
3331:
3319:
1582:
1495:
1452:
1324:
1273:
1228:
1058:from the original on 31 May 2022
988:Therapeutic Goods Administration
506:
500:
494:
29:
2333:
2303:
2272:
2242:
2175:
2132:
2091:
2032:
1968:
1949:
1930:
1911:
1892:
1873:
1778:
1734:
1704:
1674:
1594:
1472:New Drug Therapy Approvals 2018
1464:
1392:10.1016/j.antiviral.2018.10.008
1366:
1336:
946:an individual who has the flu.
916:
773:targeting the influenza virus'
755:
696:
596:Key:RZVPBGBYGMDSBG-GGAORHGYSA-N
2470:. 29 June 2018. Archived from
1562:"Drug Trial Snapshot: Xofluza"
1162:
1038:
1008:
518:
512:
488:
249:
56:BXM (S-033188), BXA (S-033447)
1:
3091:Russian flu (1889–1890)
2516:
2428:10.1016/S2213-2600(18)30469-7
2153:10.1080/13543784.2019.1606210
1170:"Xofluza Product information"
1016:"Xofluza Product information"
963:
733:
3384:Drugs developed by Genentech
2279:Otake T (24 February 2018).
2214:Branswell H (27 June 2018).
1851:10.1016/j.coviro.2019.01.006
1791:Nature Reviews. Microbiology
1566:Food and Drug Administration
1479:Food and Drug Administration
1436:Food and Drug Administration
1305:Food and Drug Administration
1257:Food and Drug Administration
1212:Food and Drug Administration
927:Food and Drug Administration
812:
687:Food and Drug Administration
609:, sold under the brand name
7:
2409:Mushtaq A (December 2018).
2104:Clinical Drug Investigation
1839:Current Opinion in Virology
10:
3435:
2866:Transmission and infection
2359:– via Business Wire.
2329:– via publicnow.com.
2066:10.1038/s41598-019-53945-1
1616:– via Business Wire.
871:
858:United States Adopted Name
478:Chemical and physical data
3281:
3228:
3203:
3165:
3158:
3146:Central Luzon H5N6 (2017)
3124:
3086:Influenza pandemic (1557)
3081:Influenza pandemic (1510)
3071:
3060:
3023:
2948:
2939:
2919:
2910:
2853:
2817:
2808:
2788:
2760:
2751:
2606:
2570:
2524:
2189:Pharmaceutical Substances
2117:10.1007/s40261-018-0697-2
1756:10.1038/s41564-019-0609-0
1438:(FDA). 23 November 2020.
1141:European Medicines Agency
691:first-in-class medication
579:
559:
537:
524:
482:
477:
445:
425:
405:
385:
365:
340:
320:
292:
287:
226:
221:
196:
182:
156:
92:
78:
60:
52:
42:
37:
28:
3188:2007 Australian outbreak
2315:Shionogi & Co., Ltd.
2018:10.1021/acs.oprd.9b00144
1307:(FDA). 16 October 2019.
1259:(FDA). 7 December 2018.
1214:(FDA). 24 October 2018.
799:neuraminidase inhibitors
2975:Neuraminidase inhibitor
2456:Drug Information Portal
3289:Influenza-like illness
2958:Adamantane derivatives
1434:(Press release). U.S.
1210:(Press release). U.S.
841:
3394:Nitrogen heterocycles
3359:Anti-influenza agents
3139:1989–1990 UK outbreak
3101:Asian flu (1957-1958)
2393:10.1056/NEJMoa1915341
1651:10.1056/NEJMoa1716197
1481:(FDA). January 2019.
836:
3354:Anti–RNA virus drugs
3106:Hong Kong flu (1968)
2898:Pandemic preparation
2464:"Baloxavir marboxil"
2452:"Baloxavir marboxil"
2184:"Baloxavir Marboxil"
1688:. 26 November 2019.
16:Antiviral medication
3409:Sulfur heterocycles
3389:Japanese inventions
2347:. 17 October 2019.
2256:. 3 November 2016.
2057:2019NatSR...917464Y
1803:10.1038/nrmicro3367
1744:Nature Microbiology
1145:. 9 November 2020.
1103:. 28 October 2019.
1054:. 23 October 2014.
925:(JMHLW) and the US
912:Society and culture
862:carbonic acid ester
765:Mechanism of action
740:acquired resistance
648:activity, used in "
245:(Prescription only)
25:
3096:Spanish flu (1918)
3015:Baloxavir marboxil
2840:West Bengal (2008)
2775:1977 (Russian flu)
2770:1918 (Spanish flu)
2317:23 February 2018.
2285:Japan Times Online
2254:ClinicalTrials.gov
2045:Scientific Reports
842:
607:Baloxavir marboxil
130:Baloxavir_marboxil
23:Baloxavir marboxil
21:
3307:
3306:
3224:
3223:
3154:
3153:
3134:Fujian flu (H3N2)
3056:
3055:
2935:
2934:
2906:
2905:
2861:Genetic structure
2804:
2803:
2608:Influenza A virus
2547:Genome sequencing
2415:Lancet Respir Med
2343:(Press release).
2313:(Press release).
2110:(11): 1053–1060.
1718:(Press release).
1022:. 25 April 2012.
747:Contraindications
604:
603:
550:Interactive image
447:CompTox Dashboard
276:
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3369:Carbonate esters
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3324:
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3322:
3315:
3238:Acute bronchitis
3163:
3162:
3116:Swine flu (2009)
3111:1977 Russian flu
3069:
3068:
3005:
2946:
2945:
2917:
2916:
2815:
2814:
2780:2009 (Swine flu)
2758:
2757:
2578:Orthomyxoviridae
2511:
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2012:(7): 1298–1307.
2001:
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992:. 2 March 2020.
979:
821:derivative of a
771:enzyme inhibitor
638:enzyme inhibitor
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3364:Antiviral drugs
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2950:Antiviral drugs
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2888:Human mortality
2881:clinical trials
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2800:
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2477:
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2474:on 26 July 2020
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2421:(12): 903–904.
2380:N. Engl. J. Med
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2368:Further reading
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1638:N. Engl. J. Med
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2557:Superinfection
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2525:General topics
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3374:Fluoroarenes
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2830:India (2006)
2552:Reassortment
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222:Legal status
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3414:4-Pyridones
3399:Morpholines
3258:Pharyngitis
3204:Non-mammals
2985:Laninamivir
2980:Oseltamivir
2968:Rimantadine
2796:2009 A/H1N1
2598:Influenza D
2593:Influenza C
2588:Influenza B
2583:Influenza A
2325:23 February
1976:"Baloxavir"
1446:23 November
1385:: 109–117.
902:Switzerland
883:viral loads
879:oseltamivir
803:oseltamivir
777:-dependent
644:-dependent
619:influenza B
615:influenza A
533: g·mol
288:Identifiers
80:MedlinePlus
53:Other names
44:Trade names
3348:Categories
3010:Umifenovir
3002:Peramivir
2963:Amantadine
2941:Treatments
2562:Flu season
2355:23 October
1716:EurekAlert
1222:23 October
1153:25 January
964:References
943:indication
866:4-pyridone
823:polycyclic
734:Resistance
710:indication
668:bronchitis
657:polymerase
538:3D model (
526:Molar mass
416:505CXM6OHG
387:ChemSpider
322:CAS Number
297:IUPAC name
3268:Sinusitis
3263:Pneumonia
3159:Non-human
3126:Epidemics
3073:Pandemics
3064:epidemics
3043:Pandemrix
2995:Zanamivir
2990:Peramivir
2927:2020–2022
2920:Outbreaks
2835:UK (2007)
2818:Outbreaks
2762:Pandemics
2542:Treatment
2518:Influenza
2345:Genentech
2295:8 January
2264:11 August
2199:8 January
2169:131775842
2026:197172102
1845:: 14–18.
1772:208279215
1726:8 January
1696:8 January
1612:11 August
1576:7 January
1536:9 January
1526:Drugs.com
1111:9 January
1000:16 August
813:Chemistry
807:zanamivir
703:antiviral
676:sinusitis
652:" by the
356:124081896
184:Routes of
158:Pregnancy
72:Monograph
66:Drugs.com
3404:Prodrugs
3326:Medicine
3025:Vaccines
2610:subtypes
2532:Research
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2402:32640124
2349:Archived
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2126:30203386
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1101:DailyMed
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994:Archived
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933:granted
921:Japan's
906:Roche AG
895:Japanese
891:Shionogi
827:Shionogi
819:pyridone
801:such as
680:headache
664:diarrhea
623:by mouth
396:59718643
367:DrugBank
198:ATC code
191:By mouth
173: B3
160:category
125:DailyMed
3338:Viruses
3312:Portals
3166:Mammals
2876:Vaccine
2854:Science
2789:Science
2571:Viruses
2537:Vaccine
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2076:6877583
2053:Bibcode
1986:28 July
1980:PubChem
1812:5619696
1568:(FDA).
1564:. U.S.
1303:. U.S.
1255:. U.S.
1179:3 March
904:-based
893:Co., a
872:History
846:in vivo
787:primers
685:The US
630:prodrug
611:Xofluza
484:Formula
376:DB13997
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2165:S2CID
2022:S2CID
1863:S2CID
1768:S2CID
1664:S2CID
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2753:H1N1
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