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1118:. Umifenovir is characterized by only one polymorphic form but can exist in the form of a large number of crystal solvates, the production of which depends on the medium and conditions of synthesis. Umifenovir is poorly soluble in water. Crystaline solvates and other solid forms may be determined by the spatial structure and conformational equilibria in the saturated solution.
1205:
helped patients with mild to moderate COVID-19. A similar study comparing
Umifenovir directly with Lopinavir/Ritonavir found no difference in fever duration between the two groups but found a lower viral load on day 14 in the Umifenovir group. A systemic review and meta-analysis of 16 studies on
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The maximum concentration of umifenovir in blood plasma when taking a dose of 50 mg is achieved after 1.2 hours, with 100 mg the maximum dose is obtained after 1.5 hours. The bioavailability of the drug is about 40% and does not depend on food intake.
1152:(then-Minister of Healthcare) to promote umifenovir, and the unsubstantiated claim that Arbidol can speed up recovery from flu or cold by 1.3-2.3 days. They also made claims that comparative clinical studies have proven umifenovir to be inefficient.
2304:
65:, is a useful starting point for translations, but translators must revise errors as necessary and confirm that the translation is accurate, rather than simply copy-pasting machine-translated text into the English Knowledge.
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Shi L, Xiong H, He J, Deng H, Li Q, Zhong Q, et al. (2007). "Antiviral activity of arbidol against influenza A virus, respiratory syncytial virus, rhinovirus, coxsackie virus and adenovirus in vitro and in vivo".
1101:
but also by several other enzymes. About 40% is excreted unchanged, mainly in bile (38.9%) and in small amounts by the kidneys (0.12%). During the first 24 hours, 90% of the administered dose is eliminated.
1860:
Leneva IA, Russell RJ, Boriskin YS, Hay AJ (February 2009). "Characteristics of arbidol-resistant mutants of influenza virus: implications for the mechanism of anti-influenza action of arbidol".
1206:
Umifenovir published in March 2021 concluded that there is "no significant benefit of using
Arbidol compared with non‐antiviral treatment or other therapeutic agents against COVID‐19 disease."
951:
and in a clinical setting. In 2010 Arbidol was the drug brand with the highest sales volume in Russia. In the first quarter of 2020 it had a 16 percent share in the
Russian antiviral market.
1297:"Pharmacokinetic properties and bioequivalence of two formulations of arbidol: an open-label, single-dose, randomized-sequence, two-period crossover study in healthy Chinese male volunteers"
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Testing of umifenovir's efficacy has mainly occurred in China and Russia, and it is well known in these two countries. Some of the
Russian tests showed the drug to be effective against
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core, functionalized at all but one positions with different substituents. The molecular groups of umifenovir - hydroxy, amino and carboxy - can form different hydrogen-bonded
1451:"[Sensitivity of various influenza virus strains to arbidol. Influence of arbidol combination with different antiviral drugs on reproduction of influenza virus A]"
75:
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Belov KV, Dyshin AA, Khodov IA (March 2024). "Conformational analysis of arbidol in supercritical carbon
Dioxide: Insights into 'opened' and 'closed' conformer groups".
817:
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Do not translate text that appears unreliable or low-quality. If possible, verify the text with references provided in the foreign-language article.
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2580:"Efficacy and Safety of Lopinavir/Ritonavir or Arbidol in Adult Patients with Mild/Moderate COVID-19: An Exploratory Randomized Controlled Trial"
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InChI=1S/C22H25BrN2O3S/c1-5-28-22(27)20-18(13-29-14-9-7-6-8-10-14)25(4)17-11-16(23)21(26)15(19(17)20)12-24(2)3/h6-11,26H,5,12-13H2,1-4H3
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2360:"Antimonopoly Service of Russia found violation in advertisement of drug, which stated its effectiveness against COVID-2019 - Crane IP"
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bird flu epidemic, but their application was rejected on the grounds that the lab data provided was not strong enough to justify use.
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In
January 2020, the Russian drug company OTCPharm (Отисифарм) published advertisements stating that the drug is effective against
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In 2007, the
Russian Academy of Medical Sciences stated that the effects of Arbidol (umifenovir) are not scientifically proven.
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Boriskin YS, Leneva IA, Pécheur EI, Polyak SJ (2008). "Arbidol: a broad-spectrum antiviral compound that blocks viral fusion".
37:
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went viral on
Facebook and circulated heavily on WhatsApp, and around the same time a shortage of the drug ensued in Russia.
2449:"Antiviral Activity of Umifenovir In Vitro against a Broad Spectrum of Coronaviruses, Including the Novel SARS-CoV-2 Virus"
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1544:"Virus susceptibility and clinical effectiveness of anti-influenza drugs during the 2010-2011 influenza season in Russia"
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of the target cell is inhibited. This prevents viral entry to the target cell, and therefore protects it from infection.
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1616:"Most popular antiviral medication brands in the Russian pharmaceutical market in 1st quarter 2020 by sales value share"
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1956:"Arbidol (Umifenovir): A Broad-Spectrum Antiviral Drug That Inhibits Medically Important Arthropod-Borne Flaviviruses"
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Content in this edit is translated from the existing
Russian Knowledge article at ]; see its history for attribution.
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Umifenovir inhibits membrane fusion of influenza virus in vitro. Fusion between the viral envelope (surrounding the
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1403:"Full Prescribing Information: Arbidol (umifenovir) film-coated tablets 50 and 100 mg: Corrections and Additions"
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2678:"Efficacy and safety of arbidol (umifenovir) in patients with COVID-19: A systematic review and meta-analysis"
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Hulseberg CE, Fénéant L, Szymańska-de Wijs KM, Kessler NP, Nelson EA, Shoemaker CJ, et al. (April 2019).
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in China, where it was sometimes given to patients in combination with other drugs such as the anti-HIV drug
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Leneva IA, Burtseva EI, Yatsyshina SB, Fedyakina IT, Kirillova ES, Selkova EP, et al. (February 2016).
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fined the company for violation of its advertising rules. In March 2020 a video promoting the drug for
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infection of mammalian cells when introduced either in advance of viral infection or during infection.
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Leneva I, Kartashova N, Poromov A, Gracheva A, Korchevaya E, Glubokova E, et al. (August 2021).
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Pécheur EI, Borisevich V, Halfmann P, Morrey JD, Smee DF, Prichard M, et al. (January 2016).
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Some evidence suggests that the drug's actions are more effective at preventing infections from
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2541:"Efficacies of lopinavir/ritonavir and arbidol in the treatment of novel coronavirus pneumonia"
1642:"Biochemical mechanism of hepatitis C virus inhibition by the broad-spectrum antiviral arbidol"
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639:
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Pécheur EI, Lavillette D, Alcaras F, Molle J, Boriskin YS, Roberts M, et al. (May 2007).
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in children include sensitization to the drug. No known overdose cases have been reported and
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2430:"China's health officials say priority is to stop mild coronavirus cases from getting worse"
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viruses, umifenovir exhibits modulatory effects on the immune system. The drug stimulates a
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Haviernik J, Štefánik M, Fojtíková M, Kali S, Tordo N, Rudolf I, et al. (April 2018).
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1897:"Structural basis of influenza virus fusion inhibition by the antiviral drug Arbidol"
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1742:"The Synthetic Antiviral Drug Arbidol Inhibits Globally Prevalent Pathogenic Viruses"
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1355:"Pharmacokinetics, metabolism, and excretion of the antiviral drug arbidol in humans"
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2382:"The campaign to promote a mysterious Soviet-era drug as a coronavirus miracle cure"
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2007:"Arbidol: a broad-spectrum antiviral that inhibits acute and chronic HCV infection"
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1791:"Arbidol and Other Low-Molecular-Weight Drugs That Inhibit Lassa and Ebola Viruses"
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The half-life is about 17-21 hours. It is metabolized in the liver primarily by
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Proceedings of the
National Academy of Sciences of the United States of America
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2629:"Arbidol monotherapy is superior to lopinavir/ritonavir in treating COVID-19"
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in mammalian cell cultures, while confirming umifenovir's suppressive effect
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In 2006 the American company Good Earth Medicine applied to the FDA for an
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958:. The drug has also been investigated as a candidate drug for treatment of
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246:
2125:"Conformational Screening of Arbidol Solvates: Investigation via 2D NOESY"
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Wang MZ, Cai BQ, Li LY, Lin JT, Su N, Yu HX, et al. (June 2004). "".
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Li Y, Xie Z, Lin W, Cai W, Wen C, Guan Y, et al. (December 2020).
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if you can. Unsourced or poorly sourced material may be challenged and
104:
to the source of your translation. A model attribution edit summary is
2465:
1972:
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40% excrete as unchanged umifenovir in feces (38.9%) and urine (0.12%)
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2408:"Coronavirus: are cocktail therapies for flu and HIV the magic cure?"
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Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
1409:(in Russian). Open joint-stock company "Pharmstandard-Tomskchempharm"
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Bangkok and Hangzhou hospitals put combination remedies to the test.
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Zhu Z, Lu Z, Xu T, Chen C, Yang G, Zha T, et al. (July 2020).
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Chen J, Ling Y, Xi X, Liu P, Li F, Li T, et al. (2020-02-21).
1461:(8). ИЗДАТЕЛЬСТВО "МЕДИЦИНА" (Publishing House "Medicine"): 84–88.
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2500:"Drug treatment options for the 2019-new coronavirus (2019-nCoV)"
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In early 2020 umifenovir was touted as a potential treatment for
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In the early 2010s Russian media criticized lobbying attempts by
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1115:
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62:
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Glushkov RG, Gus'kova TA, Krylova LI, Nikolaeva IS (1999). "".
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1953:
1691:"Mosquito-Borne Flaviviruses and Current Therapeutic Advances"
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1639:
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Deng P, Zhong D, Yu K, Zhang Y, Wang T, Chen X (April 2013).
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Liu MY, Wang S, Yao WF, Wu HZ, Meng SN, Wei MJ (April 2009).
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Eventova VA, Belov KV, Efimov SV, Khodov IA (January 2023).
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Leneva IA, Fediakina IT, Gus'kova TA, Glushkov RG (2005).
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Some preliminary research suggests it could be useful for
254:
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1859:
74:
to this template: there are already 928 articles in the
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Amani B, Amani B, Zareei S, Zareei M (December 2021).
2675:
4296:
2274:. Russian Academy of Medical Sciences. 16 March 2007.
2004:
1189:. A three-arm RCT study published in May 2020 in the
931:(FDA) for the treatment or prevention of influenza.
2272:
Meetings of the Presidium of the Formulary Committee
972:
Some studies also indicate that umifenovir also has
58:
839:
CCOC(=O)c1c(n(c2c1c(c(c(c2)Br)O)CN(C)C)C)CSc3ccccc3
1061:As well as specific antiviral action against both
2173:
4320:
2005:Boriskin YS, Pécheur EI, Polyak SJ (July 2006).
1352:
538:
2344:[Repetition - the mother of learning].
513:
2102:Vestnik Rossiiskoi Akademii Meditsinskikh Nauk
2055:
166:Please review the contents of the article and
100:accompanying your translation by providing an
49:Click for important translation instructions.
36:expand this article with text translated from
3489:
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1998:
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1633:
1548:International Journal of Infectious Diseases
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1294:
1257:"ИНСТРУКЦИЯ ПО ПРИМЕНЕНИЮ АРПЕТОЛ (ARPETOL)"
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2305:"13 most popular flu cures: do they work?"
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492:ethyl 6-bromo-4--5-hydroxy-1-methyl-2--1
2302:
1221:
1219:
986:Kaposi's sarcoma-associated herpesvirus
713:
558:
4321:
2545:Chinese Journal of Infectious Diseases
2208:
1688:
1337:
1279:
731:
4286:US influenza statistics by flu season
3477:
2744:
2557:10.3760/cma.j.cn311365-20200210-00050
1439:
1359:Antimicrobial Agents and Chemotherapy
976:effectiveness at preventing entry of
679:
658:
638:
2736:. U.S. National Library of Medicine.
2321:
1895:Kadam RU, Wilson IA (January 2017).
1584:"Russian Pharmaceutical Market 2010"
1216:
1130:A Russian packet of Arbidol capsules
685:
363:
135:
18:
3085:Sofosbuvir/velpatasvir/voxilaprevir
2286:"How do we plant federal ministers"
1110:Chemically, umifenovir features an
1088:
1034:
954:Umifenovir is used primarily as an
618:
529:
13:
4281:2017–2018 United States flu season
2682:Immunity, Inflammation and Disease
2497:
2428:Zheng W, Lau M (4 February 2020).
2405:
1429:"FDA Approved Drugs for Influenza"
1177:COVID-19 drug repurposing research
927:). It is not approved by the U.S.
14:
4385:
4020:Live attenuated influenza vaccine
3070:Ombitasvir/paritaprevir/ritonavir
2722:
1433:U.S. Food and Drug Administration
1197:found that neither Umifenovir or
1159:. Shortly afterwards the Russian
969:infection like West Nile virus.
956:antiviral treatment for influenza
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2309:Professional Journalism Platform
1077:-production, and stimulates the
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1874:10.1016/j.antiviral.2008.10.009
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1682:
1608:
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1313:10.1016/j.clinthera.2009.04.016
1263:(in Belarusian). Archived from
1029:
1003:
864:Key:KCFYEAOKVJSACF-UHFFFAOYSA-N
771:
2326:[Stick in the wheel].
2303:Golunov I (23 December 2013).
2211:"PIND number 73,739 - arbidol"
1473:
1421:
1395:
1249:
934:
915:. The drug is manufactured by
786:
780:
759:
168:add the appropriate references
110:You may also add the template
1:
4078:Russian flu (1889–1890)
3503:
2811:protease inhibitors (–previr)
2142:10.3390/pharmaceutics15010226
1209:
943:and a direct comparison with
2380:Cockerell I (2 April 2020).
2292:(in Russian). 21 April 2011.
2188:10.1016/j.molliq.2024.124074
2176:Journal of Molecular Liquids
1233:(in Chinese). Archived from
1161:Federal Antimonopoly Service
1105:
929:Food and Drug Administration
895:, sold under the brand name
112:{{Translated|ru|Умифеновир}}
7:
1589:. DSM Group. Archived from
1509:Current Medicinal Chemistry
1407:State Register of Medicines
1136:Emergency Use Authorization
1015:are limited to people with
153:reliable medical references
82:will aid in categorization.
10:
4390:
3853:Transmission and infection
2645:10.1016/j.jinf.2020.03.060
2596:10.1016/j.medj.2020.04.001
2342:"Повторение — мать учения"
1689:Qian X, Qi Z (June 2022).
1561:10.1016/j.ijid.2016.01.001
1521:10.2174/092986708784049658
1174:
980:(Kikwit strain), Tacaribe
947:showed similar efficiency
749:Chemical and physical data
57:Machine translation, like
4374:Drugs in the Soviet Union
4268:
4215:
4190:
4152:
4145:
4133:Central Luzon H5N6 (2017)
4111:
4073:Influenza pandemic (1557)
4068:Influenza pandemic (1510)
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2104:(in Russian) (3): 36–40.
2071:10.1007/s00705-007-0974-5
924:
899:, is sold and used as an
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159:or relies too heavily on
38:the corresponding article
4175:2007 Australian outbreak
3197:neuraminidase inhibitors
3060:Glecaprevir/pibrentasvir
2633:The Journal of Infection
2434:South China Morning Post
2412:South China Morning Post
2406:Ng E (4 February 2020).
4354:Dimethylamino compounds
3962:Neuraminidase inhibitor
2734:Drug Information Portal
2247:good-earth-medicine.com
1922:10.1073/pnas.1617020114
1457:(Russian translation).
1455:Terapevticheskii Arkhiv
1071:humoral immune response
121:For more guidance, see
4276:Influenza-like illness
3945:Adamantane derivatives
3400:Multiple/Unknown/Other
3169:adamantane derivatives
3080:Sofosbuvir/velpatasvir
3075:Sofosbuvir/daclatasvir
2517:10.5582/bst.2020.01020
2024:10.1186/1743-422X-3-56
1138:of Arbidol during the
1131:
4329:Anti-influenza agents
4126:1989–1990 UK outbreak
4088:Asian flu (1957-1958)
3268:inhibitors (–trelvir)
3256:Peginterferon alfa-2b
3251:Peginterferon alfa-2a
3065:Ledipasvir/sofosbuvir
1301:Clinical Therapeutics
1171:Research for COVID-19
1129:
1122:History and criticism
1054:than infections from
1026:is more than 4 g/kg.
496:-indole-3-carboxylate
123:Knowledge:Translation
94:copyright attribution
4334:Anti–RNA virus drugs
4093:Hong Kong flu (1968)
3885:Pandemic preparation
3055:Elbasvir/grazoprevir
2059:Archives of Virology
1807:10.1128/JVI.02185-18
1758:10.1128/JVI.02077-15
1371:10.1128/aac.02282-12
1227:"阿比朵尔抑制新冠，先声药业生产的吗？"
901:antiviral medication
2972:inhibitors (–buvir)
2900:inhibitors (–asvir)
2498:Lu H (March 2020).
1913:2017PNAS..114..206K
1849:on 4 February 2009.
1839:"АРБИДОЛ (ARBIDOL)"
1795:Journal of Virology
1746:Journal of Virology
1596:on 20 December 2018
249:
4083:Spanish flu (1918)
4002:Baloxavir marboxil
3827:West Bengal (2008)
3762:1977 (Russian flu)
3757:1918 (Spanish flu)
3461:Never to phase III
3319:RNA pol inhibitors
3246:Interferon alfa 2b
3151:Baloxavir marboxil
1862:Antiviral Research
1435:. 8 December 2022.
1267:on 26 January 2018
1132:
1013:allergic reactions
245:
102:interlanguage link
4294:
4293:
4211:
4210:
4141:
4140:
4121:Fujian flu (H3N2)
4043:
4042:
3922:
3921:
3893:
3892:
3848:Genetic structure
3791:
3790:
3595:Influenza A virus
3534:Genome sequencing
3471:
3470:
3430:
3429:
3093:
3092:
3048:Combination drugs
2590:(1): 105–113.e4.
2504:BioScience Trends
2466:10.3390/v13081665
2243:"FDA and Arbidol"
1973:10.3390/v10040184
1708:10.3390/v14061226
1658:10.1021/bi700181j
1652:(20): 6050–6059.
1195:Clinical Advances
890:
889:
818:Interactive image
699:CompTox Dashboard
411:
402:
393:
241:
240:
217:
134:
133:
50:
46:
16:Chemical compound
4381:
4311:
4310:
4309:
4302:
4225:Acute bronchitis
4150:
4149:
4103:Swine flu (2009)
4098:1977 Russian flu
4056:
4055:
3992:
3933:
3932:
3904:
3903:
3802:
3801:
3767:2009 (Swine flu)
3745:
3744:
3565:Orthomyxoviridae
3498:
3491:
3484:
3475:
3474:
3234:
3233:
3230:Multiple/general
2801:
2800:
2765:
2758:
2751:
2742:
2741:
2737:
2716:
2715:
2705:
2694:10.1002/iid3.502
2688:(4): 1197–1208.
2673:
2667:
2666:
2656:
2624:
2618:
2617:
2607:
2575:
2569:
2568:
2536:
2530:
2529:
2519:
2495:
2489:
2488:
2478:
2468:
2444:
2438:
2437:
2425:
2419:
2418:
2403:
2397:
2396:
2394:
2392:
2377:
2371:
2370:
2368:
2366:
2356:
2350:
2349:
2338:
2332:
2331:
2324:"Палка в колеса"
2319:
2313:
2312:
2300:
2294:
2293:
2282:
2276:
2275:
2264:
2258:
2257:
2255:
2253:
2239:
2233:
2232:
2230:
2228:
2222:
2216:. Archived from
2215:
2206:
2200:
2199:
2171:
2165:
2164:
2154:
2144:
2120:
2114:
2113:
2097:
2091:
2090:
2065:(8): 1447–1455.
2053:
2047:
2046:
2036:
2026:
2011:Virology Journal
2002:
1996:
1995:
1985:
1975:
1951:
1945:
1944:
1934:
1924:
1892:
1886:
1885:
1857:
1851:
1850:
1845:. Archived from
1835:
1829:
1828:
1818:
1786:
1780:
1779:
1769:
1752:(6): 3086–3092.
1737:
1731:
1730:
1720:
1710:
1686:
1680:
1679:
1669:
1637:
1631:
1630:
1628:
1626:
1612:
1606:
1605:
1603:
1601:
1595:
1588:
1580:
1574:
1573:
1563:
1539:
1533:
1532:
1515:(10): 997–1005.
1504:
1498:
1497:
1477:
1471:
1470:
1446:
1437:
1436:
1425:
1419:
1418:
1416:
1414:
1399:
1393:
1392:
1382:
1365:(4): 1743–1755.
1350:
1335:
1334:
1324:
1292:
1277:
1276:
1274:
1272:
1253:
1247:
1246:
1244:
1242:
1223:
1150:Tatyana Golikova
1089:Pharmacokinetics
1035:Pharmacodynamics
1017:hypersensitivity
978:Zaire ebolavirus
926:
886:
885:
878:
820:
800:
788:
782:
776:
773:
767:
761:
744:
733:
722:
721:
707:
705:
689:
683:
662:
642:
622:
602:
582:
562:
542:
532:
531:
517:
457:
407:
398:
389:
367:
304:
296:
266:
257:
250:
248:
244:
236:
235:
227:
224:
218:
216:
175:
144:
143:
136:
113:
107:
81:
80:|topic=
78:, and specifying
63:Google Translate
48:
44:
27:
26:
19:
4389:
4388:
4384:
4383:
4382:
4380:
4379:
4378:
4319:
4318:
4317:
4307:
4305:
4297:
4295:
4290:
4264:
4207:
4186:
4137:
4107:
4052:
4050:
4039:
4006:
3990:
3937:Antiviral drugs
3918:
3889:
3875:Human mortality
3868:clinical trials
3836:
3787:
3771:
3734:
3598:
3596:
3589:
3553:
3507:
3502:
3472:
3467:
3466:
3451:Clinical trials
3426:
3395:
3314:
3260:
3225:
3135:
3111:
3089:
3043:
2961:
2892:
2790:
2769:
2728:
2725:
2720:
2719:
2674:
2670:
2625:
2621:
2576:
2572:
2537:
2533:
2496:
2492:
2445:
2441:
2426:
2422:
2404:
2400:
2390:
2388:
2378:
2374:
2364:
2362:
2358:
2357:
2353:
2340:
2339:
2335:
2320:
2316:
2301:
2297:
2284:
2283:
2279:
2266:
2265:
2261:
2251:
2249:
2241:
2240:
2236:
2226:
2224:
2220:
2213:
2207:
2203:
2172:
2168:
2121:
2117:
2098:
2094:
2054:
2050:
2003:
1999:
1952:
1948:
1893:
1889:
1858:
1854:
1837:
1836:
1832:
1787:
1783:
1738:
1734:
1687:
1683:
1638:
1634:
1624:
1622:
1614:
1613:
1609:
1599:
1597:
1593:
1586:
1582:
1581:
1577:
1540:
1536:
1505:
1501:
1478:
1474:
1447:
1440:
1427:
1426:
1422:
1412:
1410:
1401:
1400:
1396:
1351:
1338:
1293:
1280:
1270:
1268:
1255:
1254:
1250:
1240:
1238:
1237:on 17 June 2020
1225:
1224:
1217:
1212:
1179:
1173:
1124:
1108:
1091:
1037:
1032:
1024:
1006:
937:
881:
879:
876:(what is this?)
873:
868:
865:
860:
855:
854:
843:
840:
835:
834:
823:
798:
785:
779:
770:
764:
725:
701:
693:
665:
645:
625:
605:
585:
565:
545:
528:
520:
500:
497:
488:
487:
455:
431:Bioavailability
423:Pharmacokinetic
417:
406:
397:
371:
330:
323:
312:
237:
233:
228:
222:
219:
176:
165:
161:primary sources
145:
141:
130:
129:
128:
111:
105:
79:
51:
28:
24:
17:
12:
11:
5:
4387:
4377:
4376:
4371:
4366:
4361:
4356:
4351:
4346:
4341:
4336:
4331:
4316:
4315:
4292:
4291:
4289:
4288:
4283:
4278:
4272:
4270:
4269:Related topics
4266:
4265:
4263:
4262:
4257:
4252:
4247:
4242:
4237:
4232:
4227:
4221:
4219:
4213:
4212:
4209:
4208:
4206:
4205:
4200:
4194:
4192:
4188:
4187:
4185:
4184:
4179:
4178:
4177:
4167:
4162:
4156:
4154:
4147:
4143:
4142:
4139:
4138:
4136:
4135:
4130:
4129:
4128:
4117:
4115:
4109:
4108:
4106:
4105:
4100:
4095:
4090:
4085:
4080:
4075:
4070:
4064:
4062:
4053:
4048:
4045:
4044:
4041:
4040:
4038:
4037:
4032:
4027:
4022:
4016:
4014:
4008:
4007:
4005:
4004:
3999:
3994:
3991:(experimental)
3986:
3985:
3984:
3979:
3974:
3969:
3959:
3958:
3957:
3952:
3941:
3939:
3930:
3924:
3923:
3920:
3919:
3917:
3916:
3910:
3908:
3901:
3895:
3894:
3891:
3890:
3888:
3887:
3882:
3877:
3872:
3871:
3870:
3860:
3855:
3850:
3844:
3842:
3838:
3837:
3835:
3834:
3832:2020s outbreak
3829:
3824:
3819:
3814:
3812:Croatia (2005)
3808:
3806:
3799:
3793:
3792:
3789:
3788:
3786:
3785:
3779:
3777:
3773:
3772:
3770:
3769:
3764:
3759:
3753:
3751:
3742:
3736:
3735:
3733:
3732:
3727:
3722:
3717:
3712:
3707:
3702:
3697:
3692:
3687:
3682:
3677:
3672:
3667:
3662:
3657:
3652:
3647:
3642:
3637:
3632:
3627:
3622:
3617:
3612:
3607:
3601:
3599:
3594:
3591:
3590:
3588:
3587:
3582:
3577:
3572:
3567:
3561:
3559:
3555:
3554:
3552:
3551:
3546:
3544:Superinfection
3541:
3536:
3531:
3526:
3521:
3515:
3513:
3512:General topics
3509:
3508:
3501:
3500:
3493:
3486:
3478:
3469:
3468:
3465:
3464:
3463:
3462:
3459:
3448:
3442:
3436:
3435:
3432:
3431:
3428:
3427:
3425:
3424:
3419:
3414:
3409:
3403:
3401:
3397:
3396:
3394:
3393:
3391:Valopicitabine
3388:
3383:
3378:
3373:
3368:
3363:
3358:
3353:
3348:
3343:
3338:
3333:
3328:
3322:
3320:
3316:
3315:
3313:
3312:
3302:
3297:
3287:
3282:
3277:
3271:
3269:
3262:
3261:
3259:
3258:
3253:
3248:
3242:
3240:
3231:
3227:
3226:
3224:
3223:
3213:
3208:
3192:
3191:
3185:
3180:
3164:
3163:
3158:
3153:
3147:
3145:
3137:
3136:
3134:
3133:
3121:
3119:
3113:
3112:
3110:
3109:
3103:
3101:
3095:
3094:
3091:
3090:
3088:
3087:
3082:
3077:
3072:
3067:
3062:
3057:
3051:
3049:
3045:
3044:
3042:
3041:
3036:
3031:
3026:
3021:
3016:
3011:
3006:
3001:
2996:
2991:
2986:
2981:
2975:
2973:
2970:RNA polymerase
2963:
2962:
2960:
2959:
2954:
2949:
2944:
2939:
2934:
2929:
2924:
2919:
2914:
2909:
2903:
2901:
2894:
2893:
2891:
2890:
2885:
2880:
2875:
2870:
2865:
2860:
2855:
2850:
2845:
2840:
2835:
2830:
2825:
2820:
2814:
2812:
2798:
2792:
2791:
2768:
2767:
2760:
2753:
2745:
2739:
2738:
2724:
2723:External links
2721:
2718:
2717:
2668:
2639:(1): e21–e23.
2619:
2570:
2547:(in Chinese).
2531:
2490:
2439:
2420:
2398:
2372:
2351:
2333:
2314:
2295:
2277:
2259:
2234:
2209:Rohrabaugh G.
2201:
2166:
2115:
2092:
2048:
1997:
1946:
1907:(2): 206–214.
1887:
1868:(2): 132–140.
1852:
1830:
1781:
1732:
1681:
1632:
1607:
1575:
1534:
1499:
1488:(3): 289–293.
1472:
1438:
1420:
1394:
1336:
1307:(4): 784–792.
1278:
1248:
1214:
1213:
1211:
1208:
1172:
1169:
1123:
1120:
1107:
1104:
1090:
1087:
1036:
1033:
1031:
1028:
1022:
1005:
1002:
936:
933:
888:
887:
870:
869:
867:
866:
863:
861:
858:
850:
849:
848:
845:
844:
842:
841:
838:
830:
829:
828:
825:
824:
822:
821:
813:
811:
803:
802:
796:
790:
789:
783:
777:
768:
762:
757:
751:
750:
746:
745:
735:
727:
726:
724:
723:
715:DTXSID60895015
710:
708:
695:
694:
692:
691:
675:
673:
667:
666:
664:
663:
655:
653:
647:
646:
644:
643:
635:
633:
627:
626:
624:
623:
615:
613:
607:
606:
604:
603:
595:
593:
587:
586:
584:
583:
575:
573:
567:
566:
564:
563:
555:
553:
547:
546:
544:
543:
535:
533:
522:
521:
519:
518:
510:
508:
502:
501:
499:
498:
491:
483:
482:
481:
478:
477:
473:
472:
469:
463:
462:
459:
450:
449:
443:
437:
436:
433:
427:
426:
419:
418:
416:
415:
386:
384:
378:
377:
373:
372:
370:
369:
356:
354:
348:
347:
333:
331:administration
325:
324:
322:
321:
317:
315:
307:
306:
287:
283:
282:
279:
273:
272:
268:
267:
259:
258:
239:
238:
231:
229:
148:
146:
139:
132:
131:
127:
126:
119:
108:
86:
83:
71:adding a topic
66:
55:
52:
33:
32:
31:
29:
22:
15:
9:
6:
4:
3:
2:
4386:
4375:
4372:
4370:
4369:Russian drugs
4367:
4365:
4362:
4360:
4357:
4355:
4352:
4350:
4347:
4345:
4342:
4340:
4337:
4335:
4332:
4330:
4327:
4326:
4324:
4314:
4304:
4303:
4300:
4287:
4284:
4282:
4279:
4277:
4274:
4273:
4271:
4267:
4261:
4258:
4256:
4253:
4251:
4248:
4246:
4243:
4241:
4238:
4236:
4233:
4231:
4230:Bronchiolitis
4228:
4226:
4223:
4222:
4220:
4218:
4217:Complications
4214:
4204:
4203:Fujian (H5N1)
4201:
4199:
4196:
4195:
4193:
4189:
4183:
4180:
4176:
4173:
4172:
4171:
4168:
4166:
4163:
4161:
4158:
4157:
4155:
4151:
4148:
4144:
4134:
4131:
4127:
4124:
4123:
4122:
4119:
4118:
4116:
4114:
4110:
4104:
4101:
4099:
4096:
4094:
4091:
4089:
4086:
4084:
4081:
4079:
4076:
4074:
4071:
4069:
4066:
4065:
4063:
4061:
4057:
4054:
4049:Pandemics and
4046:
4036:
4033:
4031:
4028:
4026:
4023:
4021:
4018:
4017:
4015:
4013:
4009:
4003:
4000:
3998:
3995:
3993:
3987:
3983:
3980:
3978:
3975:
3973:
3970:
3968:
3965:
3964:
3963:
3960:
3956:
3953:
3951:
3948:
3947:
3946:
3943:
3942:
3940:
3938:
3934:
3931:
3929:
3925:
3915:
3912:
3911:
3909:
3905:
3902:
3900:
3896:
3886:
3883:
3881:
3880:Social impact
3878:
3876:
3873:
3869:
3866:
3865:
3864:
3861:
3859:
3858:Global spread
3856:
3854:
3851:
3849:
3846:
3845:
3843:
3839:
3833:
3830:
3828:
3825:
3823:
3820:
3818:
3815:
3813:
3810:
3809:
3807:
3803:
3800:
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2348:(in Russian).
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2223:on 2021-11-04
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732:ECHA InfoCard
728:
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687:RCSB PDB
682:
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660:ChEMBL1214598
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340:hard capsules
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271:Clinical data
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194:
191:
187:
184: –
183:
179:
178:Find sources:
173:
169:
163:
162:
158:
154:
149:This article
147:
138:
137:
124:
120:
117:
109:
103:
99:
95:
91:
87:
84:
77:
76:main category
73:
72:
67:
64:
60:
56:
54:
53:
47:
41:
39:
34:You can help
30:
21:
20:
4364:Ethyl esters
4260:Strep throat
4240:Otitis media
3996:
3817:India (2006)
3539:Reassortment
3366:Molnupiravir
3361:Mericitabine
3331:Deuremidevir
3305:Simnotrelvir
3290:Nirmatrelvir
3280:Ibuzatrelvir
3266:3CL protease
3195:
3167:
3160:
3124:
3117:Picornavirus
3039:Uprifosbuvir
2937:Pibrentasvir
2888:Voxilaprevir
2858:Paritaprevir
2733:
2730:"Umifenovir"
2685:
2681:
2671:
2636:
2632:
2622:
2587:
2583:
2573:
2548:
2544:
2534:
2510:(1): 69–71.
2507:
2503:
2493:
2456:
2452:
2442:
2433:
2423:
2415:
2411:
2401:
2389:. Retrieved
2385:
2375:
2363:. Retrieved
2354:
2345:
2336:
2327:
2322:Svetlana R.
2317:
2308:
2298:
2289:
2280:
2271:
2268:"Resolution"
2262:
2250:. Retrieved
2246:
2237:
2225:. Retrieved
2218:the original
2204:
2179:
2175:
2169:
2132:
2128:
2118:
2101:
2095:
2062:
2058:
2051:
2014:
2010:
2000:
1963:
1959:
1949:
1904:
1900:
1890:
1865:
1861:
1855:
1847:the original
1842:
1833:
1798:
1794:
1784:
1749:
1745:
1735:
1698:
1694:
1684:
1649:
1646:Biochemistry
1645:
1635:
1623:. Retrieved
1619:
1610:
1598:. Retrieved
1591:the original
1578:
1551:
1547:
1537:
1512:
1508:
1502:
1485:
1481:
1475:
1458:
1454:
1432:
1423:
1411:. Retrieved
1406:
1397:
1362:
1358:
1304:
1300:
1269:. Retrieved
1265:the original
1260:
1251:
1239:. Retrieved
1235:the original
1230:
1194:
1180:
1154:
1147:
1144:
1133:
1109:
1096:
1092:
1081:function of
1060:
1049:
1041:viral capsid
1038:
1030:Pharmacology
1009:Side effects
1007:
1004:Side effects
989:
973:
971:
964:
953:
948:
938:
925:Фармстандарт
896:
892:
891:
880:
874:
640:CHEBI:134730
493:
454:Elimination
382:Legal status
376:Legal status
242:
220:
210:
203:
196:
189:
182:"Umifenovir"
177:
157:verification
150:
98:edit summary
89:
69:
43:
35:
4344:Bromoarenes
4245:Pharyngitis
4191:Non-mammals
3972:Laninamivir
3967:Oseltamivir
3955:Rimantadine
3783:2009 A/H1N1
3585:Influenza D
3580:Influenza C
3575:Influenza B
3570:Influenza A
3447:from market
3412:Merimepodib
3386:Triazavirin
3381:Taribavirin
3341:Galidesivir
3336:Favipiravir
3300:Rupintrivir
3285:Lufotrelvir
3275:Ensitrelvir
3220:Laninamivir
3206:Oseltamivir
3188:Rimantadine
3126:viral entry
3107:Bulevirtide
3099:Hepatitis D
2957:Velpatasvir
2912:Daclatasvir
2907:Coblopasvir
2883:Vedroprevir
2853:Narlaprevir
2848:Grazoprevir
2843:Glecaprevir
2838:Faldaprevir
2818:Asunaprevir
2796:Hepatitis C
2777:(primarily
2459:(8): 1665.
1701:(6): 1226.
1083:macrophages
1067:influenza B
1063:influenza A
1056:DNA viruses
1052:RNA viruses
994:Hepatitis B
960:hepatitis C
945:oseltamivir
941:influenza A
935:Medical use
801: g·mol
738:100.247.800
515:131707-25-0
476:Identifiers
461:17–21 hours
289:AR-1I9514,
286:Other names
277:Trade names
151:needs more
45:(June 2020)
4359:Thioethers
4323:Categories
3997:Umifenovir
3989:Peramivir
3950:Amantadine
3928:Treatments
3549:Flu season
3422:Presatovir
3417:Moroxydine
3351:Remdesivir
3309:+ritonavir
3294:+ritonavir
3238:Interferon
3183:Amantadine
3178:Adapromine
3161:Umifenovir
3131:Pleconaril
3034:Radalbuvir
3029:TMC-647055
3019:Sofosbuvir
3014:Setrobuvir
2994:Deleobuvir
2979:Beclabuvir
2952:Samatasvir
2942:Ravidasvir
2932:Ombitasvir
2922:Ledipasvir
2878:Vaniprevir
2873:Telaprevir
2868:Sovaprevir
2863:Simeprevir
2833:Danoprevir
2828:Ciluprevir
2823:Boceprevir
2775:antivirals
2386:Coda Story
2182:: 124074.
2135:(1): 226.
1966:(4): 184.
1210:References
1191:Cell Press
1175:See also:
1157:SARS-CoV-2
1079:phagocytic
1075:interferon
1073:, induces
1043:) and the
998:poliovirus
982:arenavirus
967:flavivirus
893:Umifenovir
806:3D model (
794:Molar mass
671:PDB ligand
600:93M09WW4RU
571:ChemSpider
506:CAS Number
485:IUPAC name
441:Metabolism
247:Umifenovir
193:newspapers
40:in Russian
4255:Sinusitis
4250:Pneumonia
4146:Non-human
4113:Epidemics
4060:Pandemics
4051:epidemics
4030:Pandemrix
3982:Zanamivir
3977:Peramivir
3914:2020–2022
3907:Outbreaks
3822:UK (2007)
3805:Outbreaks
3749:Pandemics
3529:Treatment
3505:Influenza
3457:Phase III
3445:Withdrawn
3376:Ribavirin
3346:GS-441524
3216:Peramivir
3211:Zanamivir
3156:Pimodivir
3142:influenza
3024:Tegobuvir
2999:Filibuvir
2989:Dasabuvir
2927:Odalasvir
2772:RNA virus
2565:1000-6680
2196:267232952
1554:: 77–84.
1203:Ritonavir
1199:Lopinavir
1187:Darunavir
1106:Chemistry
905:influenza
467:Excretion
456:half-life
445:Hepatic,
329:Routes of
311:Pregnancy
223:July 2020
116:talk page
68:Consider
4313:Medicine
4012:Vaccines
3597:subtypes
3519:Research
2947:Ruzasvir
2917:Elbasvir
2712:34347937
2663:32283143
2614:32838353
2551:: E008.
2526:31996494
2485:34452529
2161:36678855
2110:10222830
2087:13595688
2079:17497238
2043:16854226
1992:29642580
1941:28003465
1882:19028526
1825:30700611
1776:26739045
1727:35746697
1676:17455911
1620:Statista
1570:26775570
1529:18393857
1494:15266832
1467:16206613
1389:23357765
1331:19446151
1193:journal
1183:COVID-19
1165:COVID-19
1116:synthons
990:in vitro
974:in vitro
949:in vitro
883:(verify)
551:DrugBank
352:ATC code
336:By mouth
313:category
92:provide
4349:Phenols
4339:Indoles
4153:Mammals
3863:Vaccine
3841:Science
3776:Science
3558:Viruses
3524:Vaccine
3371:NITD008
3009:IDX-184
3004:GS-6620
2781:, also
2703:8426686
2654:7195393
2605:7235585
2476:8402645
2453:Viruses
2346:Esquire
2328:Esquire
2152:9865235
2034:1559594
1983:5923478
1960:Viruses
1932:5240704
1909:Bibcode
1816:6450122
1767:4810626
1718:9229039
1695:Viruses
1667:2532706
1625:17 June
1600:17 June
1380:3623363
1322:7133634
1271:17 June
1241:17 June
921:Russian
897:Arbidol
755:Formula
560:DB13609
526:PubChem
404:Rx-only
368:)
362: (
360:J05AX13
344:tablets
299:Chinese
295:Арбидол
291:Russian
281:Arbidol
207:scholar
172:removed
114:to the
96:in the
42:.
4299:Portal
4170:Equine
4165:Feline
4160:Canine
4035:Audenz
4025:Brands
3440:WHO-EM
3356:MK-608
3326:CMX521
3144:agents
2710:
2700:
2661:
2651:
2612:
2602:
2563:
2524:
2483:
2473:
2391:1 July
2365:1 July
2252:1 July
2227:1 July
2194:
2159:
2149:
2108:
2085:
2077:
2041:
2031:
2017:: 56.
1990:
1980:
1939:
1929:
1880:
1823:
1813:
1774:
1764:
1725:
1715:
1674:
1664:
1568:
1527:
1492:
1465:
1413:3 June
1387:
1377:
1329:
1319:
1112:indole
1099:CYP3A4
1019:. The
909:Russia
832:SMILES
799:477.42
651:ChEMBL
620:D10558
580:116151
540:131411
447:CYP3A4
301::
209:
202:
195:
188:
180:
4235:Croup
4198:Avian
4182:Swine
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