290:, though Comb continued to serve as Chairman of the Board of Directors. In October 2020 Comb passed away at the age of 93. NEB employs over 450 people at its headquarters. As company policy, all scientists and some executives must work at least one day per month on the customer support telephone line, answering technical support questions about the company's products. In 2022 Jim Ellard stepped down as CEO, but remained chairman of the board of directors, he was succeeded by Salvatore (Sal) Russello, previously NEB's director of OEM & customized solutions.
27:
458:, the restriction enzyme database, contains the details of commercial and research endonucleases. In 2011 the company founded Polbase, an online database which provides information specifically about polymerases. Another free NEB database is InBase, an intein database, which includes the Intein Registry and information about each intein.
375:
NEB provides purification kits for both DNA and RNA. In May 2019, NEB released the
Monarch Genomic DNA Purification Kit which is designed to minimize RNA contamination and allow high-yield purification of large DNA fragments. NEB’s nucleic acid purification products have been used in various studies,
346:
In
December 2017, the company released the NEBNext Ultra II FS DNA library prep kit for next-generation sequencing (NGS). In October 2019, NEB released a new RNA depletion product, the NEBNext Globin & rRNA Depletion Kit (Human/Mouse/Rat) and NEBNext rRNA Depletion Kit (Bacteria). The kits offer
474:
in 2014. To enable point-of-use sales of its reagents, NEB created a digital interface for enzyme-housing freezers to be used at customer storage sites, through a partnership with Ionia Corp. and
Salesforce.com. The data is used by the company for both sales logistics and as a part of future enzyme
438:
RNA isolation kits were also used to develop assays to detect SARS-CoV-2. NEB’s
Monarch Total RNA Miniprep Kit was not designed specifically for viral RNA extraction, but it was successfully used by different companies to extract viral RNA from biological samples. NEB also released a supplementary
366:
The NEBuilder HiFi DNA Assembly
Cloning Kit and Master Mix enable one-step cloning and multiple DNA fragment assembly. The proprietary DNA polymerase in the NEBuilder HiFi enzyme mix can assemble DNA fragments ranging from 100 bp to 19 kb. NEB also offers the Gibson Assembly Master Mix.
347:
specific depletion of the RNA species that interfere with the analysis of coding and non-coding RNAs. That same month, the company announced its NEBNext Direct
Genotyping Solution. The product delivers a one day, automatable genotyping workflow for a variety of applications in
286:. Its headquarters are in Ipswich, MA. Development of the current headquarters began in 2000, and was completed in 2005. Donald Comb served as the company's Chairman and CEO from the company's founding in 1974, until 2005. In 2005, he was replaced as chief executive by
316:
manufacturing facility near its headquarters in
Ipswich, Massachusetts, and the 40,000-sq-ft facility was completed in 2018. The multi-product Rowley Cleanroom Manufacturing Facility makes GMP-grade products and has a 10,000-sq-ft mechanical mezzanine.
196:
professor, as a cooperative laboratory of experienced scientists and initially produced restriction enzymes on a commercial scale. Comb held the CEO title until 2005 when, at 78 years old, he moved from management back into research at the firm.
427:(LAMP) assay for research use. This assay can be used to test for the presence of virus through nucleic acid detection, returning results in only 30 minutes. In 2020, the LAMP method was one of several molecular tests used to detect RNA from
972:
774:
999:
401:
Purification of RNA from mouse samples in a study identifying a pathway that selectively regulates cancer stem cells, which may be responsible for treatment resistance, tumor metastasis, and disease recurrence.
1103:
Tipton, Craig D.; Wolcott, Randall D.; Sanford, Nicholas E.; Miller, Clint; Pathak, Gita; Silzer, Talisa K.; Sun, Jie; Fleming, Derek; Rumbaugh, Kendra P.; Little, Todd D.; Phillips, Nicole (2020-06-18).
442:
Three next-generation sequencing kits to support SARS-CoV-2 monitoring were launched in
February, 2021. These kits, based on ARTIC Network protocols, provide virus transmission and evolution insights.
497:
That same month, NEB entered a partnership with Bioz, Inc., an artificial intelligence technology company, to provide its customers with access to examples of real-world applications of its products.
1676:
470:, “catalogues samples of organisms from all over the world, to be made available to scientists for research”. Though originally located on the NEB campus, OGLF relocated to the Nahant campus of
446:
In April, 2021, the Color SARS-CoV-2 RT-LAMP Diagnostic Assay, utilizing New
England Biolabs reagents, was approved for emergency use at Color Health Inc in Burlingame, California.
1023:
699:
1048:
624:
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In June 2019, NEB, Waters, and Genos announced they would work together on The Human
Glycome Project, a global initiative to map the structure and function of human
1840:
1163:
Lee, Yan-Jiun; Dai, Nan; Walsh, Shannon E.; MĂĽller, Stephanie; Fraser, Morgan E.; Kauffman, Kathryn M.; Guan, Chudi; CorrĂŞa, Ivan R.; Weigele, Peter R. (2018).
1835:
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company which produces and supplies recombinant and native enzyme reagents for life science research. It also provides products and services supporting
1354:
Albaqami, Maria; Hammad, Merfat; Pooam, Marootpong; Procopio, Maria; Sameti, Mahyar; Ritz, Thorsten; Ahmad, Margaret; Martino, Carlos F. (2020-07-09).
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on recycling and reclamation initiatives when its products and packaging come to the end of their use or lifecycle. As of 2015, NEB also had a
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1222:
Crawford, Karen; Quiroz, Juan F. Diaz; Koenig, Kristen M.; Ahuja, Namrata; Albertin, Caroline B.; Rosenthal, Joshua J. C. (2020-09-07).
814:
1790:
775:"Reforest the Tropics and New England Biolabs, Inc. enter into agreement to plant 100 hectares of forest to offset carbon emissions"
494:. NEB will supply a version of its Rapid PNGase F technology to aid in increased sample preparation and improve process throughput.
387:
Purification of RNA from wound biopsies to study the relationship between genetics, wound microbiome diversity, and wound healing.
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1165:"Identification and biosynthesis of thymidine hypermodifications in the genomic DNA of widespread bacterial viruses"
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1289:"Arf1-mediated lipid metabolism sustains cancer cells and its ablation induces anti-tumor immune responses in mice"
1830:
895:
1287:
Wang, Guohao; Xu, Junji; Zhao, Jiangsha; Yin, Weiqin; Liu, Dayong; Chen, WanJun; Hou, Steven X. (2020-01-10).
1484:
Shen, Minzhe; Zhou, Ying; Ye, Jiawei; Abdullah Al-Maskri, Abdu Ahmed; Kang, Yu; Zeng, Su; Cai, Sheng (2020).
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726:
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313:
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1441:
Tanner, NA; Evans, TC (2014). "Loop-mediated isothermal amplification for detection of nucleic acids".
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596:
557:
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173:
1024:"ERS Genomics and New England Biolabs sign agreement to commercialize CRISPR/Cas9 tools, reagents"
471:
466:
In 2001, NEB co-founded the marine DNA library Ocean Genome Legacy (OGL), which according to the
354:
In January 2020, NEB signed an agreement with ERS Genomics Limited that gave NEB rights to sell
480:
330:
In January 2017, NEB released Luna universal quantitative real-time polymerase chain reaction (
193:
64:
1575:"EMERGENCY USE AUTHORIZATION (EUA) SUMMARY FOR THE COLOR SARS-COV-2 RT-LAMP DIAGNOSTIC ASSAY"
1049:"New England Biolabs, Inc. Introduces Novel Cloning And DNA Assembly Method: NEBuilder® HiFi"
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seedlings in a study demonstrating the first known response by a biological receptor to
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973:"New England Biolabs helps Researchers to Tackle Transcriptomics in Bacteria and Blood"
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1356:"Arabidopsis cryptochrome is responsive to Radiofrequency (RF) electromagnetic fields"
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Purification of genomic DNA used to discover naturally-occurring DNA modifications in
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1106:"Patient genetics is linked to chronic wound microbiome composition and healing"
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1637:"Product Watch: Thermo Fisher's PikoReal System; New England Biolabs' Polbase"
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1486:"Recent advances and perspectives of nucleic acid detection for coronavirus"
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1719:"LogMeIn Acquires Ionia for $ 12M, Intensifying "Internet of Things" Focus"
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protocol for processing saliva, buccal swabs, and nasopharyngeal samples.
921:"New England Biolabs Releases Next-Generation Sequencing Preparation Kit"
609:
519:"In loving memory of Donald G. Comb, Founder of New England Biolabs, Inc"
406:
850:"Process Cooling System Saves Both Water, Energy at New England BioLabs"
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428:
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334:) and reverse-transcription quantitative polymerase chain reaction (
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1553:"New England Biolabs supports SARS-CoV-2 monitoring with NGS kits"
1791:"Bioz Has Partnered With NEB to Empower Life Science Researchers"
1000:"New England Biolabs launches NEBNext Direct Genotyping Solution"
815:"The Morning Download: Tech Giants Act to Stop 'Next Heartbleed'"
491:
390:
Purification of genomic DNA from squid embryos used in the first
263:
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678:"New England Biolabs, Inc. opens eighth subsidiary in Australia"
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is the company's Chief Scientific Officer. He shared the 1993
1655:"New England Biolabs establishes polymerase database Polbase"
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255:
1539:"Availability of RNA Isolation Kits Not as Dire as Reported"
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338:) kits. The Luna kits are used for DNA or RNA quantitation.
223:
and DNA methylases. It pursues research in areas related to
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830:"New England Biolabs announces plans for GMP manufacturing"
331:
283:
176:. NEB also provides free access to research tools such as
1102:
1076:"New England Biolabs Monarch Genomic DNA Purification Kit"
1221:
1589:
1417:"NYC Scientists Swab the Subway in Search of SARS-CoV-2"
1224:"Highly Efficient Knockout of a Squid Pigmentation Gene"
192:
The company was founded in 1974 by Donald "Don" Comb, a
594:
Staff (1 April 2015). "News: Products & Services".
204:(SBIR) grants between 2009 and 2013 for this research.
309:
in eukaryotic DNA and the mechanism of gene-splicing.
145:
1677:"Researchers collecting DNA from the ocean's depths"
896:"Universal Kits Optimized for DNA, RNA Quantitation"
727:"Firm plans $ 70M project on Ipswich 'great estate'"
370:
1648:
1646:
475:research development. It has also partnered with
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623:Writer, Julie Manganis Staff (13 October 2020).
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235:. NEB scientists also conduct basic research in
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812:
789:"New England Biolabs: Jim Ellard, Sal Russello"
270:, the U.K., and Australia, and distributors in
1841:Companies based in Essex County, Massachusetts
1836:Life science companies based in Massachusetts
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1693:
1631:
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1286:
750:"Donald Comb Created Tools for Gene-Splicing"
423:New England Biolabs developed a colorimetric
597:Genetic Engineering & Biotechnology News
558:Genetic Engineering & Biotechnology News
454:The company runs free scientific databases.
200:NEB received approximately $ 1.7 million in
1826:Biotechnology companies established in 1974
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312:In 2015, NEB committed to establishing a
625:"New England Biolabs founder dies at 93"
553:"New England Biolabs Looks Past Enzymes"
747:
725:Bill Archambeault (November 27, 2000).
418:
1813:
700:"New England BioLabs Company Overview"
622:
431:, a strain of coronavirus that causes
425:loop-mediated isothermal amplification
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1653:Rodney H. Brown (November 10, 2011).
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748:Hagerty, James R. (30 October 2020).
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358:and reagents, used for gene editing.
1846:1974 establishments in Massachusetts
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551:Philippidis, Alex (15 March 2013).
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1696:"CIOs: Choose Your Digital Future"
1602:Molecular Biology Labfax, Volume 1
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1490:Journal of Pharmaceutical Analysis
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813:Michael Hickens (April 24, 2014).
202:Small Business Innovation Research
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1767:"Introduction to Glycan Analysis"
1740:Michelle Taylor (April 8, 2014).
777:(Press release). August 15, 2019.
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371:Monarch nucleic acid purification
1639:. Genome Web. November 10, 2011.
246:The company has subsidiaries in
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1694:Nigel Fenwick (April 7, 2014).
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702:. Business Week. Archived from
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404:Purification of total RNA from
1742:"Collaborative Sustainability"
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16:American life sciences company
1:
1717:Curt Woodward (May 6, 2014).
1455:10.1002/0471142727.mb1514s105
648:Allis, Sam (August 7, 2005).
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362:Cloning and synthetic biology
1123:10.1371/journal.ppat.1008511
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7:
666:– via Newspapers.com.
39:; 50 years ago
10:
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1821:Research support companies
1503:10.1016/j.jpha.2020.02.010
1373:10.1038/s41598-020-67165-5
1314:10.1038/s41467-019-14046-9
868:"New England Biolabs, Inc"
349:Agricultural biotechnology
174:next-generation sequencing
1793:. BioSpace. June 13, 2019
1657:. Boston Business Journal
1599:Terence A. Brown (1998).
1248:10.1016/j.cub.2020.06.099
835:Pharmaceutical Processing
729:. Boston Business Journal
299:Nobel Prize in Physiology
278:, and other countries in
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1605:. Elsevier. p. 41.
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1190:10.1073/pnas.1714812115
828:Staff (June 12, 2015).
754:The Wall Street Journal
472:Northeastern University
84:Salvatore Russello, CEO
1831:Life sciences industry
1744:. Laboratory Equipment
977:The Scientist Magazine
817:. Wall Street Journal.
481:distribution agreement
321:Applications and Tools
194:Harvard Medical School
1698:. Wall Street Journal
1293:Nature Communications
925:Clinical Lab Products
900:Clinical Lab Products
521:. New England Biolabs
305:for the discovery of
219:research, as well as
1443:Curr Protoc Mol Biol
1234:(17): 3484–3490.e4.
610:10.1089/gen.35.21.05
419:Response to COVID-19
295:Richard John Roberts
1305:2020NatCo..11..220W
1240:2020CBio...30E3484C
1181:2018PNAS..115E3116L
1175:(14): E3116–E3125.
953:www.bio-itworld.com
706:on November 1, 2009
655:The Berkshire Eagle
571:10.1089/gen.33.6.02
303:Phillip Allen Sharp
213:restriction enzymes
154:New England Biolabs
93:Number of employees
21:
20:New England Biolabs
1771:www.biocompare.com
1360:Scientific Reports
927:. 20 December 2017
477:Harvard University
19:
356:CRISPR/Cas9 tools
301:or Medicine with
237:Molecular Biology
207:NEB produces 230
170:synthetic biology
160:) is an American
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63:240 County Road,
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1449:: Unit 15.14.
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233:drug discovery
229:DNA Sequencing
211:and 30 native
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166:genome editing
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1683:. 2014-04-17.
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1496:(2): 97–101.
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