269:. As part of this it has been showcased at numerous national outreach events (Great British Bioscience Festival 2014, Royal Society Satellite Exhibition 2016, New Scientist Live! 2016) as well as locally as part of initiatives to reach non-traditional outreach audiences (ScienceX at the Trafford Centre). She has also represented the local authority as a governor of a secondary school within Greater Manchester. As director of the IBCarb Network in Industrial Biotechnology and Bioenergy, Flitsch was able to drive forward the strategy for academic and industrial collaboration in the UK, following on from a whitepaper “Roadmap for Glycoscience in Europe”, which she co-authored. The work of this network has been replicated by an EU Coordination and Support Action (CarboMet) also directed by Prof. Fltisch. Additionally, she was part of a Scientist-MEP pairing scheme to aid links between research and scientific policy. She has also acted as an external examiner at a number of UK universities, including St. Andrews, Imperial College London, Liverpool, Hull and Leicester.
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science and research to policy makers and the wider community. As part of a successful bid to present at the Summer
Science Exhibition 2013 hosted by the Royal Society in London, Flitsch’s research was showcased along with collaborators from across the UK, through a series of hands-on activities and demonstrations. The initiative, called “The Complex Life of Sugars”, has become a permanent feature of the Programme of Public Engagement with Research and Researchers at the
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Department of Chemistry. Based at The Manchester Institute of Biotechnology, she is currently one of three professors of chemical biology. Additionally, Professor Flitsch is an elected member of the Royal Society of Chemistry Council of the United Kingdom and a director of the spin-out company
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Through her interdisciplinary research group, Sabine has supported the research training of over 100 staff and students. Her mentorship and guidance has allowed many of these to advance into principal investigators at a variety of institutions worldwide. Sabine has been an active in the promotion of
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labelling of proteins. She has also expanded this work to encompass modifications for spin labelling, and the study of glycoproteins and their analysis on gold plates and nanoparticles. These approaches were complemented by the use of enzymatic modifications of polysaccharides and glycoproteins to
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spin-out company Bio-Shape Ltd. Flitsch’s research is focussed on glycobiotechnology – the study of carbohydrates in applied science and biocatalysis – the application of enzymes in sustainable chemical manufacture. She is particularly recognised for her work at the interface of these two fields
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for production of fine chemical and pharmaceutical building blocks. Recently Prof. Flitsch has been at the forefront of biocatalytic research, constructing enzyme cascades and artificial synthetic pathways to allow multistep syntheses under common reaction conditions. and new approaches to
126:. During her postdoctoral research at MIT, Flitsch was involved in mutagenic studies of bacterial membrane proteins to help study protein folding in micelle membrane-like models. She was also instrumental in the development of cysteine mutant technology for
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facilitate analysis, for which Prof. Flitsch’s research group has engineered tailored biocatalysts via directed evolution, and to address the biological challenge of 'sequencing' carbohydrates through chemical and conformational means. Detailed studies of
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Sardzik R, Green AP, Laurent N, Both P, Fontana C, Voglmeir J, Weissenborn MJ, Haddoub R, Grassi P, Haslam SM, Widmalm G, Flitsch SL (2012). "Chemoenzymatic synthesis of O-mannosylpeptides in solution and on solid phase".
118:(glycoenzymology). Her research career spans over 35 years and has included many examples of pioneering work. Current research interests include the chemical analysis and biological exploitation of
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have also provided new insights into the effect of interfaces on enzyme catalysis and allowed new methods for surface chemistry and synthesis of biomolecules
Flitsch's use of recombinant
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Flitsch has been nominated for and awarded prizes including the Zeneca
Research Award (1996), the Glaxo Wellcome Award for Innovative Chemistry (1997) and is the recipient of a
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52:, where she received a First class Degree and Diploma in Chemistry. She subsequently received a Michael Wills scholarship to study for a D.Phil at the
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Both P, Green AP, Gray CJ, Sardzík R, Voglmeir J, Fontana C, Austeri M, Rejzek M, Richardson D, Field RA, Widmalm G, Flitsch SL, Eyers CE (2014).
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Career
Research Development Fellow between 2001 and 2004. In October 2004, Flitsch was awarded a personal Chair in Chemical Biology at the
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extends into the field of sustainable chemical manufacture, encompassing the discovery, development and demonstration of a range of
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Gray CJ, Migas LG, Barran PE, Pagel K, Seeberger PH, Eyers CE, Boons GJ, Pohl NL, Compagnon I, Widmalm G, Flitsch SL (2019).
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Bio-Shape ltd. Flitsch is also currently the
Scientific Director of IBCarb and CarboMet networks and is a director of the
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444:"Discrimination of epimeric glycans and glycopeptides using IM-MS and its potential for carbohydrate sequencing"
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Castangia R, Austria M, Flitsch SL (2012). "Enzymatic Amine Acyl
Exchange in Peptides on Gold Surfaces".
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Gray CJ, Weissenborn MJ, Eyers CE, Flitsch SL (2013). "Enzymatic reactions on immobilised substrates".
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570:"Applications of ion mobility mass spectrometry for high throughput, high resolution glycan analysis"
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and took up a lectureship in
Organic Chemistry, which she held for the next 6 years. She joined the
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Gray CJ, Thomas B, Upton R, Migas LG, Eyers CE, Barran PE, Flitsch SL (2016).
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Flitsch was born in Münster, North Rhine-Westphalia and was educated at the
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Research
Networks, Scientific Education and Training, Scientific Outreach
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Following her PhD, Flitsch took up a DAAD Postdoctoral
Fellowship at the
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research group based in the Manchester Interdisciplinary Biocentre.
303:"Manchester Interdisciplinary Biocentre - University of Manchester"
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School of Chemistry, where she runs an active research
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Biochimica et Biophysica Acta (BBA) - General Subjects
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76:. All three Flitsch family members are alumni of the
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and chemical biologist who holds a personal chair in
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252:Learn how and when to remove this message
16:German organic chemist and glycoscientist
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