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Leukocytosis

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in the ratio of immature to mature neutrophils and macrophages. The proportion of immature leukocytes increases due to proliferation and inhibition of granulocyte and monocyte precursors in the bone marrow which is stimulated by several products of inflammation including C3a and G-CSF. Although it
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Leukocytosis is very common in acutely ill patients. It occurs in response to a wide variety of conditions, including viral, bacterial, fungal, or parasitic infection, cancer, hemorrhage, and exposure to certain medications or chemicals including steroids. For lung diseases such as pneumonia and
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While treatment is usually not necessary in the majority of cases, hyperleukocytosis (WBC count > 50 or 100 × 10/L), which can be seen in some leukemic patients, is treated to prevent
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Leukocytosis is an expected finding in healthy women during the post-partum period and is not a cause for alarm unless accompanied by clinical manifestations of infection.
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Arbib, Nissim; Aviram, Amir; Gabbay Ben-Ziv, Rinat; Sneh, Orly; Yogev, Yariv; Hadar, Eran (2015-11-23). "The effect of labor and delivery on white blood cell count".
178:. It may also occur after strenuous exercise, convulsions such as epilepsy, emotional stress, pregnancy and labor, anesthesia, as a side effect of medication (e.g., 271:, in which either immature white blood cells (acute leukemia) or mature, yet non-functional, white blood cells (chronic leukemia) are present in peripheral blood. 435: 373: 32: 1672: 834: 242:, associated with the presence of "giant neutrophils". This fact shows suppression of bone marrow activity, as a hematological sign specific for 1317: 1602: 1665: 1171: 785: 1203: 1310: 1760: 1614: 139: 1832: 1068: 1043: 885: 848: 799: 1903: 1637: 838: 93: 65: 1099: 1571: 945: 279:
Leukocytosis can be subcategorized by the type of white blood cell that is increased in number. Leukocytosis in which
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tuberculosis, WBC count is very important for the diagnosis of the disease, as leukocytosis is usually present.
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for various types of leukocytes/WBCs. The 97.5 percentile (right limits in intervals in image, showing 95%
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of leukocytes from the vessels into tissues, or an increase in number of precursor cells in the marrow.
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The mechanism that causes leukocytosis can be of several forms: an increased release of leukocytes from
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Citing: Gale Encyclopedia of Medicine, 2008 and The American Heritage Medical Dictionary, 2007
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Atlas of Hematopathology. Morphology, Immunophenotype, Cytogenetics, and Molecular Approaches
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may indicate illness, leukocytosis is considered a laboratory finding instead of a separate
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is considered with reduced count or lack of "young neutrophils" (metamyelocytes, and
134: 1157: 1063:. P. Nagesh Rao, Sophie Song and Wayne W. Grody (eds). Academic Press. p. 642. 1942: 1898: 1873: 1860: 1777: 1767: 1737: 1129: 761: 182:), and epinephrine administration. There are five principal types of leukocytosis: 1133: 1837: 1817: 1530: 1279: 1103: 1034:
Mitchell, Richard Sheppard; Kumar, Vinay; Abbas, Abul K.; Fausto, Nelson (2007),
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storage pools, decreased margination of leukocytes onto vessel walls, decreased
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An extreme form of leukocytosis, in which the WBC count exceeds 100,000/μL, is
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This increase in leukocyte (primarily neutrophils) is usually accompanied by a
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Lutan, Vasile. Fiziopatologie medicală. Vol. 2, 31.3.2.1. Leucocitozele;
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if you can. Unsourced or poorly sourced material may be challenged and
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Essentials of Pathophysiology: Concepts of Altered Health States
318:. In this form there are so many WBCs that clumps of them block 1697: 1244: 1204:"Hyperleukocytosis and leukostasis in hematologic malignancies" 420: 331: 170:, but may also occur following certain parasitic infections or 1119: 254: 223: 159: 794:, Chicago: Britannica Educational Publishing, p. 198, 388: 1332: 1122:
The Journal of Maternal-Fetal & Neonatal Medicine
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Reference ranges for blood tests#White blood cells 2
906: 832: 226:, which is also a test result instead of a disease. 1955: 718:) is a common limit for defining leukocytosis. 869: 46:Please review the contents of the article and 1673: 1318: 1087:2015 Dec. Am Fam Physician. 1;92(11):1004-11. 222:. This classification is similar to that of 1028: 1026: 1024: 1022: 1020: 1018: 1016: 1014: 1012: 1010: 1008: 1006: 1004: 1002: 1000: 998: 996: 994: 992: 990: 988: 986: 783: 779: 777: 1097:Leukocytosis: Basics of Clinical Assessment 984: 982: 980: 978: 976: 974: 972: 970: 968: 966: 900: 1680: 1666: 1325: 1311: 877:Schwartz's Clinical Handbook of Pediatrics 1185:"Leukocytosis Treatment & Management" 1170:Specific references are found in article 1085:Evaluation of Patients with Leukocytosis. 774: 158:) count is above the normal range in the 1456: 963: 826: 720: 154:is a condition in which the white cell ( 1956: 1761:Asplenia with cardiovascular anomalies 1615:Neutrophil-specific granule deficiency 1516: 1409: 253:A leukocyte count above 25 to 30 × 10/ 1833:Intranodal palisaded myofibroblastoma 1661: 1306: 1058: 1638:Neutrophil immunodeficiency syndrome 1201: 15: 863: 821:TheFreeDictionary > Leukocytosis 705: 230:in the ratio of immature to mature 13: 907:Schwartz, M. William, ed. (2003), 14: 1980: 1218: 791:Blood: Physiology and Circulation 274: 1936:Postmastectomy lymphangiosarcoma 1904:Lymphedema–distichiasis syndrome 1531:Granulocytopenia/agranulocytosis 162:. It is frequently a sign of an 112: 20: 1195: 1177: 1164: 1113: 1090: 682:Certain medications, including 589:chronic myelomonocytic leukemia 1849:Template:Respiratory pathology 1077: 1052: 937: 914:The 5-Minute Pediatric Consult 814: 166:, most commonly the result of 48:add the appropriate references 1: 1633:Chronic granulomatous disease 1593:Leukocyte adhesion deficiency 1539:Severe congenital neutropenia 1390:Chronic granulomatous disease 1134:10.3109/14767058.2015.1110572 1059:Naeim, Faramarz, ed. (2013). 833:Porth, Carol Mattson (2011), 767: 870:Zorc, Joseph J, ed. (2009), 728: 700: 566:Systemic autoimmune diseases 521:Chronic myelogenous leukemia 479:Systemic autoimmune diseases 303:; and leukocytosis in which 7: 1931:Postinflammatory lymphedema 1823:Generalized lymphadenopathy 1691:: organ and vessel diseases 835:"White blood cell response" 757:Leukocytosis in head trauma 740: 575:Inflammatory bowel diseases 33:reliable medical references 10: 1985: 1643:Myeloperoxidase deficiency 1485:Hypereosinophilic syndrome 1038:, Philadelphia: Saunders, 784:Rogers, Kara, ed. (2011), 694:, may cause leukocytosis. 517:Myeloproliferative disease 1859: 1808: 1746: 1696: 1623: 1579: 1570: 1509: 1449: 1440: 1402: 1365: 1358: 1345: 1226: 1108:American Family Physician 786:"Leukocytosis definition" 344: 337: 328:transient ischemic attack 133: 128: 39:or relies too heavily on 1610:Chédiak–Higashi syndrome 1572:Disorder of phagocytosis 641:Infectious mononucleosis 446:Dermatitis herpetiformis 295:; leukocytosis in which 287:; leukocytosis in which 1083:Riley LK and Rupert J. 1036:Robbins Basic Pathology 345:Causes of leukocytosis 725: 712:blood reference ranges 549:Bacterial endocarditis 436:Allergic skin diseases 189:(the most common form) 1889:Congenital lymphedema 724: 658:lymphocytic leukæmias 384:Myocardial infarction 307:count is elevated is 299:count is elevated is 291:count is elevated is 269:leukoerythroblastosis 164:inflammatory response 1926:Factitial lymphedema 1916:Secondary lymphedema 752:Complete blood count 716:prediction intervals 495:Cholesterol embolism 472:Non-Hodgkin lymphoma 455:Parasitic infections 374:Sterile inflammation 365:bacterial infections 1828:Castleman's disease 1202:Schiffer, Charles. 747:Bacterial infection 369:pyogenic infections 326:problems including 1921:Bullous lymphedema 1894:Lymphedema praecox 1884:Primary lymphedema 1795:Splenic infarction 1543:Cyclic neutropenia 1102:2011-06-06 at the 726: 579:ulcerative colitis 539:Chronic infections 466:Hodgkin's lymphoma 260:leukemoid reaction 248:radiation sickness 215:"left upper shift" 140:Infectious disease 1951: 1950: 1861:Lymphatic vessels 1721:DiGeorge syndrome 1689:Lymphatic disease 1655: 1654: 1651: 1650: 1625:Respiratory burst 1566: 1565: 1562: 1561: 1505: 1504: 1436: 1435: 1432: 1431: 1398: 1397: 1300: 1299: 1110:. November 2000. 1070:978-0-12-385183-3 1045:978-1-4160-2973-1 887:978-0-7817-7013-2 850:978-1-58255-724-3 801:978-1-61530-250-5 665: 664: 244:pernicious anemia 149: 148: 123:Medical condition 121: 120: 97: 1976: 1943:Waldmann disease 1909:Milroy's disease 1899:Lymphedema tarda 1874:Lymphangiectasia 1788:Banti's syndrome 1778:Wandering spleen 1768:Accessory spleen 1738:Thymic carcinoma 1682: 1675: 1668: 1659: 1658: 1577: 1576: 1524: 1514: 1513: 1464: 1454: 1453: 1447: 1446: 1417: 1407: 1406: 1373: 1363: 1362: 1356: 1355: 1327: 1320: 1313: 1304: 1303: 1224: 1223: 1212: 1211: 1199: 1193: 1192: 1181: 1175: 1168: 1162: 1161: 1117: 1111: 1094: 1088: 1081: 1075: 1074: 1056: 1050: 1048: 1030: 961: 960: 958: 957: 948:. Archived from 941: 935: 934: 933: 931: 904: 898: 897: 896: 894: 867: 861: 860: 859: 857: 830: 824: 818: 812: 811: 810: 808: 781: 762:White blood cell 706:Leukocyte counts 625:Viral infections 342: 341: 322:. This leads to 283:are elevated is 236:band neutrophils 126: 125: 116: 115: 107: 104: 98: 96: 55: 24: 23: 16: 1984: 1983: 1979: 1978: 1977: 1975: 1974: 1973: 1969:Hematopathology 1964:Blood disorders 1954: 1953: 1952: 1947: 1855: 1838:Kikuchi disease 1818:Lymphadenopathy 1804: 1742: 1692: 1686: 1656: 1647: 1619: 1558: 1517: 1501: 1457: 1428: 1410: 1394: 1366: 1341: 1331: 1301: 1296: 1295: 1235: 1221: 1216: 1215: 1200: 1196: 1183: 1182: 1178: 1169: 1165: 1118: 1114: 1104:Wayback Machine 1095: 1091: 1082: 1078: 1071: 1057: 1053: 1046: 1032:Table 12-6 in: 1031: 964: 955: 953: 944: 942: 938: 929: 927: 925: 905: 901: 892: 890: 888: 868: 864: 855: 853: 851: 831: 827: 819: 815: 806: 804: 802: 782: 775: 770: 743: 731: 708: 703: 684:corticosteroids 635:Cytomegalovirus 507: 505: 404: 402: 379:Tissue necrosis 353: 351: 340: 277: 124: 117: 113: 108: 102: 99: 56: 45: 41:primary sources 25: 21: 12: 11: 5: 1982: 1972: 1971: 1966: 1949: 1948: 1946: 1945: 1940: 1939: 1938: 1933: 1928: 1923: 1913: 1912: 1911: 1906: 1901: 1896: 1891: 1881: 1876: 1871: 1865: 1863: 1857: 1856: 1854: 1853: 1852: 1851: 1840: 1835: 1830: 1825: 1820: 1814: 1812: 1806: 1805: 1803: 1802: 1797: 1792: 1791: 1790: 1780: 1775: 1770: 1765: 1764: 1763: 1752: 1750: 1744: 1743: 1741: 1740: 1735: 1730: 1728:Ectopic thymus 1725: 1724: 1723: 1713: 1708: 1702: 1700: 1694: 1693: 1685: 1684: 1677: 1670: 1662: 1653: 1652: 1649: 1648: 1646: 1645: 1640: 1635: 1629: 1627: 1621: 1620: 1618: 1617: 1612: 1607: 1606: 1605: 1600: 1589: 1587: 1574: 1568: 1567: 1564: 1563: 1560: 1559: 1557: 1556: 1550: 1545: 1527: 1525: 1511: 1507: 1506: 1503: 1502: 1500: 1499: 1498: 1497: 1492: 1487: 1478: 1471:granulocytosis 1467: 1465: 1451: 1444: 1438: 1437: 1434: 1433: 1430: 1429: 1427: 1426: 1420: 1418: 1404: 1400: 1399: 1396: 1395: 1393: 1392: 1387: 1382: 1376: 1374: 1360: 1353: 1343: 1342: 1330: 1329: 1322: 1315: 1307: 1298: 1297: 1294: 1293: 1282: 1271: 1252: 1236: 1231: 1230: 1228: 1227:Classification 1220: 1219:External links 1217: 1214: 1213: 1194: 1191:. 8 July 2022. 1176: 1163: 1128:(18): 2904–8. 1112: 1089: 1076: 1069: 1051: 1044: 962: 936: 923: 909:"Leukocytosis" 899: 886: 872:"Leukocytosis" 862: 849: 825: 813: 800: 772: 771: 769: 766: 765: 764: 759: 754: 749: 742: 739: 730: 727: 707: 704: 702: 699: 663: 662: 661: 660: 652:some forms of 650: 645: 644: 643: 638: 632: 622: 621: 620: 615: 600: 594: 593: 592: 591: 583:some forms of 581: 572: 563: 562: 561: 556: 551: 546: 534: 528: 527: 526: 525: 523: 511: 501: 500: 499: 498: 492: 488:Some forms of 486: 476: 475: 474: 470:Some forms of 468: 459:Some forms of 457: 452: 451: 450: 449: 448: 443: 433: 431:Drug allergies 428: 423: 410: 398: 397: 396: 395: 394: 393: 392: 391: 386: 371: 359: 347: 346: 339: 336: 276: 275:Classification 273: 211: 210: 205: 200: 195: 190: 147: 146: 137: 131: 130: 122: 119: 118: 111: 109: 62:"Leukocytosis" 28: 26: 19: 9: 6: 4: 3: 2: 1981: 1970: 1967: 1965: 1962: 1961: 1959: 1944: 1941: 1937: 1934: 1932: 1929: 1927: 1924: 1922: 1919: 1918: 1917: 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1443: 1439: 1425: 1424:Monocytopenia 1422: 1421: 1419: 1416: 1414: 1408: 1405: 1401: 1391: 1388: 1386: 1385:Histiocytosis 1383: 1381: 1378: 1377: 1375: 1372: 1370: 1364: 1361: 1357: 1354: 1352: 1348: 1344: 1340: 1336: 1328: 1323: 1321: 1316: 1314: 1309: 1308: 1305: 1292: 1288: 1287: 1283: 1281: 1277: 1276: 1272: 1270: 1266: 1262: 1261: 1257: 1253: 1251: 1247: 1246: 1242: 1238: 1237: 1234: 1229: 1225: 1209: 1205: 1198: 1190: 1186: 1180: 1173: 1167: 1159: 1155: 1151: 1147: 1143: 1139: 1135: 1131: 1127: 1123: 1116: 1109: 1105: 1101: 1098: 1093: 1086: 1080: 1072: 1066: 1062: 1055: 1047: 1041: 1037: 1029: 1027: 1025: 1023: 1021: 1019: 1017: 1015: 1013: 1011: 1009: 1007: 1005: 1003: 1001: 999: 997: 995: 993: 991: 989: 987: 985: 983: 981: 979: 977: 975: 973: 971: 969: 967: 952:on 2012-03-27 951: 947: 940: 926: 924:0-7817-3539-4 920: 916: 915: 910: 903: 889: 883: 879: 878: 873: 866: 852: 846: 842: 841: 836: 829: 822: 817: 803: 797: 793: 792: 787: 780: 778: 773: 763: 760: 758: 755: 753: 750: 748: 745: 744: 738: 736: 723: 719: 717: 713: 698: 695: 693: 692:beta agonists 689: 685: 680: 678: 677:extravasation 674: 669: 659: 655: 651: 649: 646: 642: 639: 636: 633: 631: 628: 627: 626: 623: 619: 616: 614: 611: 610: 609: 606: 603: 602: 601: 599: 598:Lymphocytosis 596: 595: 590: 586: 582: 580: 576: 573: 571: 567: 564: 560: 557: 555: 554:Rickettsiosis 552: 550: 547: 545: 542: 541: 540: 537: 536: 535: 533: 530: 529: 524: 522: 518: 515: 514: 512: 510: 506:leukocytosis 503: 502: 497:(transiently) 496: 493: 491: 487: 484: 480: 477: 473: 469: 467: 464: 463: 462: 458: 456: 453: 447: 444: 442: 439: 438: 437: 434: 432: 429: 427: 424: 422: 419: 418: 416: 413: 412: 411: 408: 403:leukocytosis 401:Eosinophilic 400: 399: 390: 387: 385: 382: 381: 380: 377: 376: 375: 372: 370: 367:, especially 366: 362: 361: 360: 357: 352:leukocytosis 350:Neutrophilic 349: 348: 343: 335: 333: 329: 325: 321: 317: 312: 310: 306: 302: 298: 294: 293:lymphocytosis 290: 286: 282: 272: 270: 266: 262: 261: 256: 251: 249: 245: 241: 237: 233: 229: 228:"Right shift" 225: 221: 216: 209: 206: 204: 201: 199: 196: 194: 193:Lymphocytosis 191: 188: 185: 184: 183: 181: 177: 173: 169: 165: 161: 157: 153: 145: 141: 138: 136: 132: 127: 110: 106: 103:November 2021 95: 92: 88: 85: 81: 78: 74: 71: 67: 64: –  63: 59: 58:Find sources: 53: 49: 43: 42: 38: 34: 29:This article 27: 18: 17: 1869:Lymphangitis 1783:Splenomegaly 1518: 1481:Eosinophilia 1476:Neutrophilia 1459: 1458: 1442:Granulocytes 1411: 1368: 1367: 1339:granulocytes 1333:Diseases of 1284: 1273: 1254: 1239: 1207: 1197: 1188: 1179: 1166: 1125: 1121: 1115: 1107: 1092: 1079: 1060: 1054: 1049:8th edition. 1035: 954:. Retrieved 950:the original 939: 928:, retrieved 913: 902: 891:, retrieved 876: 865: 854:, retrieved 839: 828: 816: 805:, retrieved 790: 732: 709: 696: 681: 670: 666: 613:Tuberculosis 544:Tuberculosis 407:eosinophilia 356:neutrophilia 313: 309:eosinophilia 285:neutrophilia 278: 258: 257:is termed a 252: 227: 214: 212: 203:Eosinophilia 187:Neutrophilia 152:Leukocytosis 151: 150: 129:Leukocytosis 100: 90: 83: 76: 69: 57: 37:verification 30: 1773:Polysplenia 1711:Hyperplasia 1548:Eosinopenia 1535:Neutropenia 1380:Monocytosis 1351:macrophages 930:12 November 893:12 November 856:13 November 807:12 November 735:leukostasis 673:bone marrow 618:Brucellosis 532:Monocytosis 504:Basophilic 316:leukostasis 301:monocytosis 281:neutrophils 240:blood smear 232:neutrophils 198:Monocytosis 174:as well as 172:bone tumors 31:needs more 1958:Categories 1879:Lymphedema 1810:Lymph node 1716:Hypoplasia 1581:Chemotaxis 1490:Basophilia 1286:DiseasesDB 956:2011-09-25 768:References 710:Below are 656:, such as 654:malignancy 608:infections 587:, such as 585:malignancy 509:Basophilia 490:vasculitis 461:malignancy 417:disorders 320:blood flow 305:eosinophil 289:lymphocyte 208:Basophilia 73:newspapers 1553:Basopenia 1347:Monocytes 1335:monocytes 1142:1476-7058 729:Treatment 701:Diagnosis 648:Pertussis 637:infection 630:Hepatitis 441:Pemphigus 426:Hay fever 267:and from 168:infection 156:leukocyte 144:pathology 135:Specialty 1756:Asplenia 1495:Bandemia 1460:-cytosis 1369:-cytosis 1208:UpToDate 1189:Medscape 1158:24541975 1150:26493469 1100:Archived 741:See also 415:Allergic 324:ischemic 297:monocyte 265:leukemia 176:leukemia 1843:Tonsils 1733:Thymoma 1706:Abscess 1280:D007964 688:lithium 605:Chronic 577:, e.g. 568:, e.g. 559:Malaria 519:, e.g. 513:(rare) 220:disease 180:lithium 87:scholar 52:removed 1748:Spleen 1698:Thymus 1520:-penia 1413:-penia 1269:288.6x 1156:  1148:  1140:  1067:  1042:  921:  884:  847:  798:  481:(e.g. 421:Asthma 363:Acute 338:Causes 332:stroke 89:  82:  75:  68:  60:  1291:33024 1265:288.3 1250:D72.8 1154:S2CID 389:Burns 238:) in 224:fever 160:blood 94:JSTOR 80:books 1847:see 1603:LAD2 1598:LAD1 1583:and 1349:and 1337:and 1275:MeSH 1260:9-CM 1146:PMID 1138:ISSN 1065:ISBN 1040:ISBN 932:2011 919:ISBN 895:2011 882:ISBN 858:2011 845:ISBN 809:2011 796:ISBN 690:and 330:and 246:and 66:news 35:for 1256:ICD 1241:ICD 1130:doi 570:SLE 483:SLE 1960:: 1289:: 1278:: 1267:, 1263:: 1248:: 1245:10 1206:. 1187:. 1152:. 1144:. 1136:. 1126:29 1124:. 1106:, 965:^ 911:, 874:, 837:, 788:, 776:^ 737:. 686:, 409:) 358:) 334:. 311:. 250:. 142:, 54:. 1681:e 1674:t 1667:v 1555:) 1541:/ 1537:/ 1533:( 1522:: 1510:↓ 1483:/ 1462:: 1450:↑ 1415:: 1403:↓ 1371:: 1359:↑ 1326:e 1319:t 1312:v 1258:- 1243:- 1233:D 1210:. 1174:. 1160:. 1132:: 1073:. 959:. 485:) 405:( 354:( 255:L 105:) 101:( 91:· 84:· 77:· 70:· 44:.

Index

reliable medical references
verification
primary sources
add the appropriate references
removed
"Leukocytosis"
news
newspapers
books
scholar
JSTOR
Specialty
Infectious disease
pathology
leukocyte
blood
inflammatory response
infection
bone tumors
leukemia
lithium
Neutrophilia
Lymphocytosis
Monocytosis
Eosinophilia
Basophilia
disease
fever
neutrophils
band neutrophils

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