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29:
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Basophilia, as it is primarily a secondary condition, is treated by addressing the causative disease or disorder. The underlying condition will determine what treatment is appropriate. Specifically in cases of allergic reactions or associated with chronic inflammation, treating the underlying cause
384:
and looks for a significant abnormality in any of the conventional karyotypes which could support the diagnosis of a neoplastic process. Basophilia on its own does not cause much complication other than those related to the primary causative condition. However, basophils can degranulate causing
192:
Basophilia can be attributed to many causes and is typically not sufficient evidence alone to signify a specific condition when isolated as a finding under microscopic examination. Coupled with other findings, such as abnormal levels of
167:
are the least numerous of the myelogenous cells, and it is rare for their numbers to be abnormally high without changes to other blood components. Rather, basophilia is most often coupled with other white blood cell conditions such as
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756:
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is critical to avoid further, potentially irreparable damage to the body's organ systems. Common treatments to allergic reactions include cessation of use of the offending agent, and the administration of
305:. Since basophilia is present in a vast range of clinical conditions, depending on a variety of underlying causes, supplemental signs and symptoms must be investigated for a diagnosis. If
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851:
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is common. This severe symptomatology may require urgent attention. If basophilia and the aforementioned symptoms are present with concurrent
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to treat the underlying causative infection, whereas neoplasm related basophilia may have a more complicated clinical course including
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also demonstrate elevated basophil levels. Certain drug usage and food ingestion can also correlate with symptoms of basophilia.
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in the blood. Basophils are easily identifiable by a blue coloration of the granules within each cell, marking them as
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329:, and right upper quadrant pain may be present in the afflicted patient. With some conditions, such as
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is detected, a myeloproliferative syndrome may be suspected. Intrinsically related symptoms such as
197:, it may suggest the need for additional workup. As an example, additional evidence of left-shifted
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may be used to confirm an increase in basophils or significantly high numbers of precursors to the
217:. Elevation of basophils may also be representative of multiple other underlying neoplasms such as
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365:
298:
574:"Proposed diagnostic criteria and classification of basophilic leukemias and related disorders"
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8:
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Valent P, Sotlar K, Blatt K, Hartmann K, Reiter A, Sadovnik I, et al. (April 2017).
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233:. Alternative root causes other than these neoplasmic complications are most commonly
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National Center for
Biotechnology Information, U.S. National Library of Medicine
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tissue damage, but this can be avoided with early detection and intervention.
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209:. Additionally, basophilia in the presence of numerous circulating
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alongside basophilia indicates a potential likelihood primarily of
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281:(CBC). The root cause of basophilia can be determined through a
28:
745:
730:
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is examined to determine cell counts.In cases of a supposed
636:. University of Virginia School of Medicine. Archived from
318:
866:
571:
398:. Infection-related basophilia can be remedied by using
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or adverse sensitivity, skin rashes may be present.
337:, or burning of the palms and soles, coupled with
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657:
630:"Leukemia: Chronic Myeloproliferative Disorders"
514:Optimizing Laboratory Workflow and Performance
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658:Valent P, Horny HP, Arock M (October 2018).
438:Sticco, Kristin; Lynch, David (2019-11-07).
155:is the condition of having greater than 200
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664:European Journal of Clinical Investigation
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420:
349:may be considered. In cases of underlying
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27:
683:
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372:analysis. This type of testing uses the
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1149:Neutrophil-specific granule deficiency
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471:Boiten HJ, de Jongh E (August 2018).
277:Basophilia can be detected through a
1172:Neutrophil immunodeficiency syndrome
13:
1217:Monocyte and granulocyte disorders
522:10.1016/b978-1-4377-0974-2.00002-6
289:to look for genetic mutations, or
14:
1228:
704:
1065:Granulocytopenia/agranulocytosis
356:After symptomatic evaluation, a
321:(itching) due to the release of
293:to determine enlargement of the
265:and infectious diseases such as
512:Dilts TJ, McPherson RA (2011).
651:
622:
505:
464:
1:
1167:Chronic granulomatous disease
1127:Leukocyte adhesion deficiency
1073:Severe congenital neutropenia
924:Chronic granulomatous disease
660:"+ chronic myeloid leukaemia"
413:
516:. Elsevier. pp. 13–23.
490:10.1182/blood-2018-05-849901
388:
345:greater than 1500 cells/μL,
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213:suggests the possibility of
7:
255:inflammatory bowel disorder
229:, or, in rare cases, solid
207:myeloproliferative neoplasm
180:, in addition to segmented
10:
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1177:Myeloperoxidase deficiency
1019:Hypereosinophilic syndrome
347:hypereosinophilic syndrome
123:inflammatory bowel disease
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446:. StatPearls Publishing.
187:
133:
103:essential thrombocythemia
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66:
52:
35:
26:
21:
1144:Chédiak–Higashi syndrome
1106:Disorder of phagocytosis
368:will be performed using
203:chronic myeloid leukemia
91:Chronic myeloid leukemia
205:(CML), or an alternate
358:peripheral blood smear
215:acute myeloid leukemia
107:acute myeloid leukemia
473:"Atypical basophilia"
257:, or an inflammatory
99:primary myelofibrosis
299:bone marrow aspirate
279:complete blood count
140:Complete blood count
59:bā-sə-ˈfi-lē-ə
590:10.1038/leu.2017.15
1077:Cyclic neutropenia
813:External resources
366:bone marrow biopsy
351:allergic reactions
283:bone marrow biopsy
259:autoimmune disease
235:allergic reactions
127:autoimmune disease
111:allergic reactions
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676:10.1111/eci.13000
531:978-1-4377-0974-2
380:for each type of
331:polycythemia vera
219:polycythemia vera
172:, high levels of
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135:Diagnostic method
95:polycythemia vera
16:Medical condition
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1005:granulocytosis
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713:Classification
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705:External links
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670:(10): e13000.
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640:on 3 June 2016
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584:(4): 788–797.
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396:antihistamines
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339:thrombocytosis
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53:Pronunciation
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1207:Granulocytes
1202:Cell biology
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1015:Eosinophilia
1010:Neutrophilia
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976:Granulocytes
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873:granulocytes
867:Diseases of
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642:. Retrieved
638:the original
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455:. Retrieved
443:
440:"Basophilia"
404:chemotherapy
392:
355:
343:eosinophilia
307:splenomegaly
303:granulocytes
276:
247:tuberculosis
239:inflammation
199:neutrophilia
191:
178:granulocytes
170:eosinophilia
161:venous blood
152:
151:
115:inflammation
42:Erythrocytes
1212:Human cells
1082:Eosinopenia
1069:Neutropenia
914:Monocytosis
885:macrophages
548:|work=
400:antibiotics
378:chromosomes
370:cytogenetic
241:related to
237:or chronic
195:neutrophils
174:eosinophils
159:/μL in the
144:blood smear
117:related to
113:or chronic
46:Thrombocyte
38:Granulocyte
36:Basophilic
1196:Categories
1115:Chemotaxis
1024:Basophilia
787:DiseasesDB
644:2016-04-07
483:(5): 551.
457:2020-01-17
414:References
408:phlebotomy
374:karyotypes
291:ultrasound
261:. Chronic
243:infections
153:Basophilia
119:infections
73:Hematology
22:Basophilia
1087:Basopenia
881:Monocytes
869:monocytes
798:SNOMED CT
550:ignored (
540:cite book
389:Treatment
382:leukocyte
323:histamine
273:Diagnosis
251:influenza
165:Basophils
157:basophils
68:Specialty
1029:Bandemia
994:-cytosis
903:-cytosis
803:65209002
694:30019447
608:28090091
578:Leukemia
499:30072416
452:30570986
319:pruritus
267:smallpox
245:such as
825:Q492764
821:Scholia
766:D72.824
751:D72.824
736:MA16.11
685:6175372
616:7068232
599:7115817
327:fatigue
315:malaise
1054:-penia
947:-penia
781:288.65
692:
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614:
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528:
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295:spleen
231:tumors
221:(PV),
211:blasts
188:Causes
182:nuclei
125:, and
87:Causes
75:
44:and a
792:29698
761:10-CM
612:S2CID
477:Blood
311:fever
1137:LAD2
1132:LAD1
1117:and
883:and
871:and
776:9-CM
690:PMID
604:PMID
552:help
526:ISBN
495:PMID
448:PMID
364:, a
297:. A
142:and
772:ICD
757:ICD
742:ICD
727:ICD
680:PMC
672:doi
594:PMC
586:doi
518:doi
485:doi
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