273:
47:
696:
727:
741:
708:
59:
361:
which also inhibits basophil function. This suggests that basophils may play a role in the immune response to these viruses. The role of basophils in the immune response to these viruses is further supported by findings that the CD200 receptor is expressed more frequently in basophils than in other
647:
Basophils are easily isolated from venous blood and present good "indicator cells" of an IgE-mediated allergic response based on the upregulation of activation markers such as CD63 and/or CD203c upon suspect allergen stimulation. Therefore, the BAT serves to confirm IgE-mediated allergy following
314:, basophils play a role in both parasitic infections and allergies. They are found in tissues where allergic reactions are occurring and probably contribute to the severity of these reactions. Basophils have protein receptors on their cell surface that bind
422:. Histamine and proteoglycans are pre-stored in the cell's granules while the other secreted substances are newly generated. Each of these substances contributes to inflammation. Recent evidence suggests that basophils are an important source of the
1378:
Grattan CE, Dawn G, Gibbs S, Francis DM (March 2003). "Blood basophil numbers in chronic ordinary urticaria and healthy controls: diurnal variation, influence of loratadine and prednisolone and relationship to disease activity".
159:. They are the largest type of granulocyte. They are responsible for inflammatory reactions during immune response, as well as in the formation of acute and chronic allergic diseases, including
260:, and mast cells usually do not circulate in the blood stream, but instead are located in connective tissue. Like all circulating granulocytes, basophils can be recruited out of the
648:
uncertain results from classical testing based on anamnesis, skin testing or specific IgE results. More recently, BAT has also been used for the monitoring of successful
1628:
438:
antibody by the immune system. There are other substances that can activate basophils to secrete which suggests that these cells have other roles in inflammation.
120:
2217:
795:
1084:
459:(a low basophil count) is difficult to demonstrate as the normal basophil count is so low; it has been reported in association with autoimmune
1621:
2135:
1748:
823:
449:
and the so-called basophil-activation-test (BAT). Especially, in the diagnosis of allergies including of drug reactions (e.g. induced by
1501:
Hoffmann HJ, et al. (2015). "The clinical utility of basophil activation testing in diagnosis and monitoring of allergic disease".
872:
635:. When activated, some additional surface markers are known to be upregulated (CD13, CD107a, CD164), or surface-exposed (CD63, and the
923:
624:
2210:
1614:
300:
1319:
917:
1466:
Heneberg P (November 2011). "Mast cells and basophils: trojan horses of conventional lin- stem/progenitor cell isolates".
2203:
866:
1439:
2549:
326:. It is the bound IgE antibody that confers a selective response of these cells to environmental substances (e.g.,
276:
127:
434:. Interleukin-4 is considered one of the critical cytokines in the development of allergies and the production of
1175:
Nakanishi K (December 2010). "Basophils as APC in Th2 response in allergic inflammation and parasite infection".
652:(desensitization) to differentiate short-term desensitization versus sustained unresponsiveness to the allergen.
195:
granules. Mast cells were once thought to be basophils that migrated from the blood into their resident tissues (
2544:
2487:
784:
115:
2018:
1826:
1092:
256:, a chemical that is secreted by the cells when stimulated. However, they arise from different branches of
1335:
Böhm I, Speck U, Schild HH (April 2011). "Pilot study on basophil activation induced by contrast medium".
2373:
272:
210:(now mast cells). Ehrlich received the 1908 Nobel Prize in Physiology or Medicine for his discoveries.
108:
695:
17:
2195:
892:
2080:
938:
583:
Recently, Heneberg proposed that basophils may be defined as the cellular population positive for
103:
91:
30:
This article is about a type of blood cell. For the endocrine cell of the anterior pituitary, see
2553:
2311:
2182:
2101:
1970:
707:
213:
The name comes from the fact that these leukocytes are basophilic, i.e., they are susceptible to
299:, which promotes blood flow to tissues. They can be found in unusually high numbers at sites of
2575:
2293:
2229:
649:
1210:
Shiratori I, Yamaguchi M, Suzukawa M, Yamamoto K, Lanier LL, Saito T, Arase H (October 2005).
815:
2651:
2646:
2522:
2378:
2356:
846:
779:
1037:"The history of mast cell and basophil research - some lessons learnt from the last century"
2656:
2539:
2472:
2383:
2307:
2177:
354:
8:
2599:
2534:
2517:
2351:
2269:
1965:
1940:
858:
2419:
2111:
1582:
1555:
1536:
1404:
1360:
1277:
1252:
1066:
1012:
987:
963:
880:
665:
395:
358:
1431:
2467:
2233:
1975:
1587:
1528:
1483:
1445:
1435:
1396:
1392:
1352:
1348:
1315:
1282:
1268:
1233:
1192:
1157:
1114:
1058:
1017:
968:
913:
862:
403:
244:
when stained. However, when unstained, the nucleus is visible and it usually has two
196:
168:
156:
148:
1540:
1408:
1364:
1070:
295:, which prevents blood from clotting too quickly. They also contain the vasodilator
252:, another granulocyte, is similar in appearance and function. Both cell types store
2587:
2527:
2499:
2494:
2462:
2449:
2439:
2052:
1955:
1770:
1577:
1567:
1518:
1510:
1475:
1427:
1388:
1344:
1272:
1264:
1223:
1212:"Down-regulation of basophil function by human CD200 and human herpesvirus-8 CD200"
1184:
1149:
1122:
1048:
1007:
999:
988:"Distinguishing mast cell and granulocyte differentiation at the single-cell level"
958:
950:
854:
769:
681:
557:
315:
279:
of white blood cells, comparing basophil amount (shown in violet) with other cells.
218:
1305:
2482:
2001:
1790:
1722:
1606:
1300:
907:
759:
746:
565:
561:
450:
96:
1228:
1211:
337:
Recent studies in mice suggest that basophils may also regulate the behavior of
2509:
2454:
2395:
2315:
2288:
2067:
2047:
1996:
1840:
1785:
1765:
1760:
1682:
1646:
1479:
1003:
954:
732:
446:
319:
206:, who one year earlier had found a cell type present in tissues that he termed
46:
1572:
1188:
1126:
2640:
2477:
2366:
2147:
2057:
1702:
1153:
1140:
Voehringer D (December 2009). "The role of basophils in helminth infection".
676:
670:
427:
375:
257:
79:
31:
2444:
2429:
2424:
2361:
2259:
2172:
2106:
2075:
1935:
1800:
1692:
1655:
1638:
1591:
1532:
1487:
1449:
1400:
1356:
1286:
1237:
1196:
1161:
1062:
1021:
972:
383:
284:
237:
203:
74:
1556:"Oral Immunotherapy and Basophil and Mast Cell Reactivity in Food Allergy"
175:. They also produce compounds that coordinate immune responses, including
1849:
1732:
1251:
Torrero, Marina; Larson, David; HĂĽbner, Marc; Mitre, Edson (March 2009).
620:
488:
Basophils of mice and humans have consistent immunophenotypes, including
411:
391:
371:
311:
188:
160:
152:
2567:
2320:
2226:
1960:
1950:
1930:
1922:
1884:
1867:
1857:
1795:
1687:
1523:
764:
636:
464:
241:
1514:
1053:
1036:
133:
2625:
2330:
2225:
2167:
2013:
1945:
1896:
1862:
1727:
1707:
1697:
1253:"CD200R surface expression as a marker of murine basophil activation"
790:
774:
460:
456:
379:
296:
253:
249:
233:
192:
180:
176:
172:
2615:
2400:
2388:
2346:
2300:
2264:
2140:
2034:
1913:
1901:
1877:
1660:
986:
Franco CB, Chen CC, Drukker M, Weissman IL, Galli SJ (April 2010).
726:
577:
472:
468:
423:
419:
399:
331:
245:
214:
1209:
632:
489:
2620:
2434:
2283:
2254:
2042:
1889:
754:
431:
387:
323:
292:
288:
184:
2592:
2580:
2325:
2276:
2130:
2006:
1670:
604:
338:
327:
164:
58:
2085:
628:
616:
612:
608:
549:
545:
517:
513:
505:
497:
493:
415:
407:
350:
261:
341:
and mediate the magnitude of the secondary immune response.
1426:. Advances in Immunology. Vol. 101. pp. 123–161.
600:
596:
592:
588:
584:
553:
541:
537:
533:
529:
525:
521:
501:
304:
199:), but they are now known to be different types of cells.
985:
509:
435:
221:
1250:
1377:
202:
Basophils were discovered in 1879 by German physician
1654:
936:
722:
1034:
796:
List of distinct cell types in the adult human body
441:The degranulation of basophils can be investigated
357:, herpesvirus-7, and herpesvirus-8 produce a CD200
1636:
1304:
937:Stone KD, Prussin C, Metcalfe DD (February 2010).
467:is also uncommon but may be seen in some forms of
1035:Blank U, Falcone FH, Nilsson G (September 2013).
2638:
1334:
155:, representing about 0.5% to 1% of circulating
1299:
943:The Journal of Allergy and Clinical Immunology
655:
2211:
1622:
939:"IgE, mast cells, basophils, and eosinophils"
191:, although there are less than that found in
1421:
1461:
1459:
283:Basophils appear in many specific kinds of
2218:
2204:
1629:
1615:
1139:
844:
291:symptoms. Basophils contain anticoagulant
57:
45:
1581:
1571:
1553:
1547:
1522:
1415:
1312:(electronic full text via NCBI Bookshelf)
1276:
1227:
1174:
1052:
1011:
962:
287:reactions, particularly those that cause
151:. Basophils are the least common type of
1500:
1494:
1465:
1456:
1293:
478:
271:
2136:Megakaryocyte–erythroid progenitor cell
1337:Fundamental & Clinical Pharmacology
1115:"Discovery and purification of heparin"
912:(2nd ed.). Elsevier. p. 180.
905:
14:
2639:
322:involved in macroparasite defense and
2199:
1610:
822:. U.S. National Library of Medicine.
1314:(5th ed.). Garland Publishing.
687:
642:
483:
1257:Clinical & Experimental Allergy
1112:
1077:
859:10.1002/9780470015902.a0001120.pub3
63:Dyed basophil among red blood cells
24:
826:from the original on 21 April 2016
349:Basophil function is inhibited by
25:
2668:
1602:
1554:Paranjape A, et al. (2020).
1381:Clinical and Experimental Allergy
1113:Lim, Gregory (17 December 2017).
1393:10.1046/j.1365-2222.2003.01589.x
1349:10.1111/j.1472-8206.2010.00826.x
1269:10.1111/j.1365-2222.2008.03154.x
926:from the original on 2018-05-04.
875:from the original on 2016-05-01.
739:
725:
706:
694:
277:Reference ranges for blood tests
128:Anatomical terms of microanatomy
1371:
1328:
1244:
1203:
1168:
463:(a chronic itching condition).
453:), the BAT is of great impact.
2545:Immunoglobulin class switching
1133:
1106:
1028:
979:
930:
909:Textbook Of Medical Physiology
899:
838:
808:
430:, perhaps more important than
370:Basophils arise and mature in
183:that induce inflammation, and
13:
1:
1468:Current Pharmaceutical Design
1432:10.1016/S0065-2776(08)01004-3
1177:Current Opinion in Immunology
851:Encyclopedia of Life Sciences
801:
785:Histamine N-methyltransferase
713:Alternate stain of a basophil
365:
1827:Extramedullary hematopoiesis
374:. When activated, basophils
227:
7:
1229:10.4049/jimmunol.175.7.4441
718:
656:Etymology and pronunciation
267:
264:into a tissue when needed.
236:granules which obscure the
224:, as shown in the picture.
10:
2673:
2374:Polyclonal B cell response
1480:10.2174/138161211798357881
1004:10.1016/j.stem.2010.02.013
955:10.1016/j.jaci.2009.11.017
845:Mukai K, Galli SJ (2013).
51:3D rendering of a basophil
29:
2608:
2566:
2508:
2409:
2339:
2247:
2240:
2160:
2120:
2094:
2066:
2033:
1993:Antigen-presenting cells
1986:
1921:
1912:
1848:
1839:
1819:
1781:
1756:
1747:
1718:
1678:
1669:
1645:
1573:10.3389/fimmu.2020.602660
1189:10.1016/j.coi.2010.10.018
1127:10.1038/nrcardio.2017.171
1119:Nature Reviews Cardiology
816:"Blood differential test"
126:
114:
102:
90:
85:
73:
68:
56:
44:
39:
2081:Nucleated red blood cell
1637:Myeloid blood cells and
1154:10.1016/j.pt.2009.09.004
362:circulating leukocytes.
344:
232:Basophils contain large
27:Type of white blood cell
2183:Hematopoietic stem cell
2102:Leukocyte extravasation
1971:Foreign-body giant cell
1560:Frontiers in Immunology
2488:Tolerance in pregnancy
2230:adaptive immune system
1303:; et al. (2001).
1142:Trends in Parasitology
650:allergen immunotherapy
280:
2523:Somatic hypermutation
2357:Polyclonal antibodies
2352:Monoclonal antibodies
1422:Schroeder JT (2009).
1216:Journal of Immunology
949:(2 Suppl 2): S73-80.
780:Histamine intolerance
479:Clinical significance
406:). They also secrete
275:
2540:Junctional diversity
2308:Antigen presentation
2178:Hematopoietic system
1966:Langhans giant cells
1089:medcell.med.yale.edu
853:. Vol. Online.
2535:V(D)J recombination
2518:Affinity maturation
2270:Antigenic variation
1941:Alveolar macrophage
1424:Chapter 4 Basophils
396:proteolytic enzymes
2112:Intrinsic immunity
1976:Touton giant cells
701:Blood cell lineage
281:
109:H2.00.04.1.02022
2634:
2633:
2562:
2561:
2312:professional APCs
2193:
2192:
2156:
2155:
2029:
2028:
1956:Epithelioid cells
1835:
1834:
1815:
1814:
1811:
1810:
1743:
1742:
1515:10.1111/all.12698
1509:(11): 1393–1405.
1321:978-0-8153-3642-6
1054:10.1111/all.12197
919:978-81-8147-850-4
688:Additional images
643:Allergy diagnosis
484:Immunophenotyping
404:lysophospholipase
303:infection (e.g.,
197:connective tissue
169:atopic dermatitis
157:white blood cells
142:
141:
137:
16:(Redirected from
2664:
2528:Clonal selection
2500:Immune privilege
2495:Immunodeficiency
2450:Cross-reactivity
2440:Hypersensitivity
2245:
2244:
2220:
2213:
2206:
2197:
2196:
2127:Precursor cells
2053:Promegakaryocyte
1919:
1918:
1846:
1845:
1771:Promegakaryocyte
1754:
1753:
1676:
1675:
1667:
1666:
1652:
1651:
1631:
1624:
1617:
1608:
1607:
1596:
1595:
1585:
1575:
1551:
1545:
1544:
1526:
1498:
1492:
1491:
1463:
1454:
1453:
1419:
1413:
1412:
1375:
1369:
1368:
1332:
1326:
1325:
1313:
1310:
1297:
1291:
1290:
1280:
1248:
1242:
1241:
1231:
1207:
1201:
1200:
1172:
1166:
1165:
1137:
1131:
1130:
1110:
1104:
1103:
1101:
1100:
1091:. Archived from
1081:
1075:
1074:
1056:
1032:
1026:
1025:
1015:
983:
977:
976:
966:
934:
928:
927:
906:Khurana (2009).
903:
897:
896:
890:
886:
884:
876:
842:
836:
835:
833:
831:
812:
770:Food intolerance
749:
744:
743:
742:
735:
730:
729:
710:
698:
149:white blood cell
134:edit on Wikidata
131:
61:
49:
37:
36:
21:
2672:
2671:
2667:
2666:
2665:
2663:
2662:
2661:
2637:
2636:
2635:
2630:
2604:
2558:
2504:
2483:Clonal deletion
2411:
2405:
2335:
2236:
2224:
2194:
2189:
2152:
2116:
2095:Immune response
2090:
2068:Red blood cells
2062:
2025:
2002:Langerhans cell
1997:Dendritic cells
1982:
1908:
1831:
1807:
1791:Proerythroblast
1777:
1739:
1723:Monocytopoiesis
1714:
1658:
1641:
1635:
1605:
1600:
1599:
1552:
1548:
1499:
1495:
1474:(34): 3753–71.
1464:
1457:
1442:
1420:
1416:
1376:
1372:
1333:
1329:
1322:
1311:
1298:
1294:
1249:
1245:
1208:
1204:
1173:
1169:
1138:
1134:
1111:
1107:
1098:
1096:
1083:
1082:
1078:
1047:(9): 1093–101.
1033:
1029:
984:
980:
935:
931:
920:
904:
900:
888:
887:
878:
877:
869:
843:
839:
829:
827:
814:
813:
809:
804:
760:Diamine oxidase
747:Medicine portal
745:
740:
738:
731:
724:
721:
714:
711:
702:
699:
690:
666:combining forms
658:
645:
575:
571:
552:, Gr-1, NK1.1,
486:
481:
451:contrast medium
418:), and several
410:mediators like
368:
347:
270:
230:
138:
64:
52:
35:
28:
23:
22:
15:
12:
11:
5:
2670:
2660:
2659:
2654:
2649:
2632:
2631:
2629:
2628:
2623:
2618:
2612:
2610:
2606:
2605:
2603:
2602:
2597:
2596:
2595:
2585:
2584:
2583:
2572:
2570:
2564:
2563:
2560:
2559:
2557:
2556:
2547:
2542:
2537:
2532:
2531:
2530:
2525:
2514:
2512:
2510:Immunogenetics
2506:
2505:
2503:
2502:
2497:
2492:
2491:
2490:
2485:
2480:
2475:
2470:
2458:
2457:
2455:Co-stimulation
2452:
2447:
2442:
2437:
2432:
2427:
2422:
2415:
2413:
2407:
2406:
2404:
2403:
2398:
2396:Immune complex
2392:
2391:
2386:
2381:
2376:
2371:
2370:
2369:
2364:
2359:
2354:
2343:
2341:
2337:
2336:
2334:
2333:
2328:
2323:
2318:
2316:Dendritic cell
2304:
2303:
2298:
2297:
2296:
2294:Conformational
2291:
2280:
2279:
2274:
2273:
2272:
2267:
2262:
2251:
2249:
2242:
2238:
2237:
2223:
2222:
2215:
2208:
2200:
2191:
2190:
2188:
2187:
2186:
2185:
2175:
2170:
2164:
2162:
2158:
2157:
2154:
2153:
2151:
2150:
2145:
2144:
2143:
2138:
2133:
2124:
2122:
2118:
2117:
2115:
2114:
2109:
2104:
2098:
2096:
2092:
2091:
2089:
2088:
2083:
2078:
2072:
2070:
2064:
2063:
2061:
2060:
2055:
2050:
2048:Megakaryoblast
2045:
2039:
2037:
2031:
2030:
2027:
2026:
2024:
2023:
2022:
2021:
2011:
2010:
2009:
2004:
1999:
1990:
1988:
1984:
1983:
1981:
1980:
1979:
1978:
1973:
1968:
1958:
1953:
1948:
1943:
1938:
1933:
1927:
1925:
1916:
1910:
1909:
1907:
1906:
1905:
1904:
1894:
1893:
1892:
1882:
1881:
1880:
1870:
1865:
1860:
1854:
1852:
1843:
1841:Myeloid tissue
1837:
1836:
1833:
1832:
1830:
1829:
1823:
1821:
1817:
1816:
1813:
1812:
1809:
1808:
1806:
1805:
1804:
1803:
1798:
1793:
1786:Erythropoiesis
1782:
1779:
1778:
1776:
1775:
1774:
1773:
1768:
1766:Megakaryoblast
1761:Thrombopoiesis
1757:
1751:
1745:
1744:
1741:
1740:
1738:
1737:
1736:
1735:
1730:
1719:
1716:
1715:
1713:
1712:
1711:
1710:
1705:
1700:
1695:
1690:
1683:Granulopoiesis
1679:
1673:
1664:
1649:
1643:
1642:
1634:
1633:
1626:
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992:Cell Stem Cell
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187:that prevents
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2148:Myelomonocyte
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2058:Megakaryocyte
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2647:Cell biology
2445:Inflammation
2430:Alloimmunity
2425:Autoimmunity
2410:Immunity vs.
2362:Autoantibody
2260:Superantigen
2107:Phagocytosis
2076:Reticulocyte
1872:
1850:Granulocytes
1801:Reticulocyte
1693:Promyelocyte
1656:Myelopoiesis
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309:
301:ectoparasite
285:inflammatory
282:
238:cell nucleus
231:
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204:Paul Ehrlich
201:
144:
143:
2657:Human cells
2568:Lymphocytes
2227:Lymphocytic
1961:giant cells
1951:Osteoclasts
1931:Histiocytes
1923:Macrophages
1733:Promonocyte
1524:1874/333232
847:"Basophils"
392:chondroitin
378:to release
376:degranulate
372:bone marrow
334:antigens).
312:eosinophils
234:cytoplasmic
161:anaphylaxis
153:granulocyte
86:Identifiers
2641:Categories
2609:Substances
2473:Peripheral
2461:Inaction:
2340:Antibodies
2321:Macrophage
2234:complement
1885:Eosinophil
1868:Neutrophil
1858:Myeloblast
1796:Normoblast
1688:Myeloblast
1099:2019-03-15
1085:"Basophil"
802:References
765:Eosinophil
684:-loving".
637:ectoenzyme
580:negative.
465:Basophilia
366:Secretions
242:microscope
240:under the
208:mastzellen
2626:Cytolysin
2616:Cytokines
2463:Tolerance
2412:tolerance
2331:Immunogen
2168:Phagocyte
2035:Platelets
2014:Monoblast
1946:Microglia
1914:Monocytes
1897:Mast cell
1863:Band cell
1728:Monoblast
1708:Band cell
1698:Myelocyte
891:ignored (
881:cite book
791:Mast cell
775:Histamine
660:The word
639:CD203c).
520:(c-kit),
461:urticaria
457:Basopenia
445:by using
420:cytokines
380:histamine
297:histamine
254:histamine
250:mast cell
228:Structure
193:mast cell
181:serotonin
177:histamine
173:hay fever
145:Basophils
18:Basophils
2576:Cellular
2420:Immunity
2418:Action:
2401:Paratope
2389:Idiotype
2379:Allotype
2347:Antibody
2301:Mimotope
2265:Allergen
2248:Antigens
2241:Lymphoid
2141:CFU-GEMM
1902:CFU-Mast
1878:CFU-Baso
1873:Basophil
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973:20176269
924:Archived
873:Archived
830:22 April
824:Archived
719:See also
662:basophil
578:integrin
500:(DX-5),
473:lymphoma
469:leukemia
443:in vitro
424:cytokine
400:elastase
332:helminth
289:allergic
268:Function
215:staining
40:Basophil
2621:Opsonin
2600:NK cell
2588:Humoral
2468:Central
2435:Allergy
2384:Isotype
2284:Epitope
2255:Antigen
2043:CFU-Meg
1890:CFU-Eos
1820:General
1583:7768812
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1041:Allergy
1013:2852254
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787:or HNMT
755:Allergy
432:T cells
394:), and
388:heparin
359:homolog
339:T cells
324:allergy
293:heparin
185:heparin
97:D001491
69:Details
2593:B cell
2581:T cell
2326:B cell
2289:Linear
2277:Hapten
2173:Plasma
2131:CFU-GM
2007:CFU-DL
1671:CFU-GM
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625:CD203c
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386:(e.g.
328:pollen
248:. The
165:asthma
75:System
2161:Other
2121:Other
2086:CFU-E
1987:Other
1537:S2CID
1405:S2CID
1361:S2CID
1067:S2CID
677:-phil
671:baso-
664:uses
633:FcεRI
629:TLR-4
617:CD193
613:CD164
609:CD123
572:and β
550:CD11c
546:CD122
542:Ly49c
518:CD117
514:CD11b
506:Thy-1
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494:CD123
490:FcεRI
416:LTD-4
408:lipid
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345:CD200
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310:Like
305:ticks
262:blood
246:lobes
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564:, αβ
560:, γδ
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508:.2,
502:CD69
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179:and
171:and
92:MeSH
2554:HLA
2550:MHC
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1578:PMC
1568:doi
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