1573:
2002:
29:
2456:
530:
440:. Adipose tissue gives "mechanical cushioning" to the body, among other functions. Although there is no dense collagen network in adipose tissue, groups of adipose cells are kept together by collagen fibers and collagen sheets in order to keep fat tissue under compression in place (for example, the sole of the foot). Both the ground substance and proteins (fibers) create the matrix for connective tissue.
2468:
271:.) Loose and dense connective tissue are distinguished by the ratio of ground substance to fibrous tissue. Loose connective tissue has much more ground substance and a relative lack of fibrous tissue, while the reverse is true of dense connective tissue. Dense regular connective tissue, found in structures such as
283:
fibers arranged in an orderly parallel fashion, giving it tensile strength in one direction. Dense irregular connective tissue provides strength in multiple directions by its dense bundles of fibers arranged in all directions.
884:
225:
216:
1587:
Betts, J Gordon; Desaix, Peter; Johnson, Eddie; Johnson, Jody E; Korol, Oksana; Kruse, Dean; Poe, Brandon; Wise, James; Womble, Mark D; Young, Kelly A (26 June 2023).
561:
to cells, and carbon dioxide and waste substances to diffuse from cells back into circulation. They also allow organs to resist stretching and tearing forces.
69:
858:
Biga, Lindsay M.; Dawson, Sierra; Harwell, Amy; Hopkins, Robin; Kaufmann, Joel; LeMaster, Mike; Matern, Philip; Morrison-Graham, Katie; Quick, Devon (2019),
1627:
1618:
1632:
1054:
593:, also provide resistance to stretch forces. They are found in the walls of large blood vessels and in certain ligaments, particularly in the
2043:
1665:
1027:
765:
1577:
541:
Connective tissue has a wide variety of functions that depend on the types of cells and the different classes of fibers involved.
731:
2093:
859:
1461:"Mapping the Ligand-binding Sites and Disease-associated Mutations on the Most Abundant Protein in the Human, Type I Collagen"
1364:
1596:
653:
Various types of specialized tissues and cells are classified under the spectrum of connective tissue, and are as diverse as
446:
is present in many forms of connective tissue, and makes up about 25% of the total protein content of the mammalian body.
1555:
1530:
1127:
1003:
2340:
546:
524:
268:
1324:"Collagen fibers, reticular fibers and elastic fibers. A comprehensive understanding from a morphological viewpoint"
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1243:
1297:
2357:
1269:
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638:
into all types of mature connective tissue. Another type of relatively undifferentiated connective tissue is the
562:
264:
432:
allowing fixation of
Collagen fibers in intercellular spaces. Examples of non-fibrous connective tissue include
316:
927:
Aterman, K. (1981). "Connective tissue: An eclectic historical review with particular reference to the liver".
650:. This tissue is no longer present after birth, leaving only scattered mesenchymal cells throughout the body.
64:
771:
1058:
232:
Connective tissue can be broadly classified into connective tissue proper, and special connective tissue.
2305:
2217:
2029:
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830:
250:
143:, are composed of connective tissue. Most types of connective tissue consists of three main components:
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2005:
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167:
are classed as specialized fluid connective tissues that do not contain fiber. All are immersed in the
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tendon, ligament, skin, cornea, cartilage, bone, blood vessels, gut, and intervertebral disc.
993:
1514:
127:. Connective tissue is found in between other tissues everywhere in the body, including the
2320:
2315:
2170:
658:
654:
405:
1581:
1572:
1081:
323:. New vascularised connective tissue that forms in the process of wound healing is termed
8:
1515:
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1855:
557:, have an important role in providing a medium for oxygen and nutrients to diffuse from
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1942:
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689:—are found scattered in loose connective tissue, providing the ground for starting
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327:. All of the special connective tissue types have been included as a subset of
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128:
109:
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1739:
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694:
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204:. The tissue was already recognized as a distinct class in the 18th century.
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105:
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1948:
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1244:"Supporting Connective Tissue | Human Anatomy and Physiology Lab (BSB 141)"
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809:
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140:
1635:
US National
Institute of Arthritis and Musculoskeletal and Skin Diseases
1380:
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1973:
1929:
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565:, which forms organized structures, is a major functional component of
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38:
34:
1591:. Houston: OpenStax CNX. 4.3 Connective Tissue supports and protects.
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2010:
1978:
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590:
296:
188:
184:
176:
2021:
829:
Biga, Lindsay M.; Dawson, Sierra; Harwell, Amy (26 September 2019).
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are epithelial with an underlying layer of loose connective tissue.
82:
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1912:
1902:
1824:
1762:
570:
554:
529:
373:
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132:
117:
28:
311:. Other kinds of connective tissues include fibrous, elastic, and
2261:
2256:
2229:
1768:
723:
698:
586:
1365:"Monitoring Tissue Engineering Using Magnetic Resonance Imaging"
995:
315:
connective tissues. Fibroareolar tissue is a mix of fibrous and
2367:
2350:
1789:
1412:"Metabolic syndrome pathophysiology: The role of adiposetissue"
991:
777:
631:
578:
566:
328:
272:
121:
715:
There are many types of connective tissue disorders, such as:
2429:
1839:
1834:
1818:
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630:
is a type of connective tissue found in developing organs of
577:, and is also found in highly specialized organs such as the
437:
377:
308:
304:
164:
160:
136:
1521:(6th ed.). Lippincott Williams & Wilkins. pp.
1160:
Bordoni, Bruno; Mahabadi, Navid; Varacallo, Matthew (2022).
2424:
2239:
2076:
1876:
1196:"Fascial nomenclature: Update on related consensus process"
670:
300:
624:(that is, the bulk of functional substance) of the organ.
1586:
1159:
857:
319:. Fibromuscular tissue is made up of fibrous tissue and
1548:
Wheater's
Functional Histology: A Text and Colour Atlas
1545:
774:(SLE) – a major autoimmune disease of connective tissue
911:
Connective Tissue, Macromolecular
Structure Evolution.
794:
that leads to an abnormal growth in the arterial wall.
2444:
1270:"Fluid or liquid connective tissue: blood and lymph"
1193:
992:
Carol
Mattson Porth; Glenn Matfin (1 October 2010).
424:
is a clear, colorless, and viscous fluid containing
2411:
1194:Schleip, R; Hedley, G; Yucesoy, CA (October 2019).
998:. Lippincott Williams & Wilkins. pp. 24–.
37:. Connective tissue (blue) is seen supporting the
2388:
1416:Nutrition, Metabolism and Cardiovascular Diseases
828:
784:which is necessary for the synthesis of collagen.
2482:
754:– a pathological weakening of connective tissue.
342:Bone and cartilage can be further classified as
1409:
985:
490:Allow organs like arteries and lungs to recoil
2037:
1659:
1458:
860:"4.3 Connective Tissue Supports and Protects"
349:. Blood and lymph can also be categorized as
287:
195:
1628:Connective tissue atlas, University of Iowa
1512:
235:
2044:
2030:
1666:
1652:
1155:
1153:
766:undifferentiated connective tissue disease
474:Bind bones and other tissues to each other
372:. Connective tissue membranes include the
27:
1476:
1435:
1339:
1219:
512:liver, bone marrow, and lymphatic organs
194:The term "connective tissue" (in German,
171:. The cells of connective tissue include
1633:Heritable disorders of connective tissue
1369:Journal of Bioscience and Bioengineering
704:
528:
1539:
1508:
1506:
1504:
1502:
1500:
1498:
1496:
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1290:
1187:
1150:
1095:
926:
815:
732:malignant peripheral nerve sheath tumor
2483:
1673:
1550:(6th ed.). Elsevier. p. 65.
1546:Young B, Woodford P, O'Dowd G (2013).
1362:
1321:
1315:
913:Springer-Verlag, Berlin and New York.
853:
851:
849:
847:
368:can be either of connective tissue or
2051:
2025:
1647:
1267:
822:
673:. Cells of the immune system—such as
1493:
1410:Laclaustra, M.; et al. (2007).
1287:
1103:"Medical Definition of FIBROAREOLAR"
877:
96:is one of the four primary types of
16:Type of biological tissue in animals
969:
844:
13:
1639:Connective tissue photomicrographs
1328:Archives of Histology and Cytology
1268:Karki, Gaurab (23 February 2018).
1052:
1025:
866:, OpenStax/Oregon State University
535:inherited connective tissue defect
506:Form a scaffolding for other cells
376:(the three membranes covering the
335:, with blood and lymph classed as
269:dense irregular connective tissues
14:
2502:
2341:Dense irregular connective tissue
1609:
547:dense irregular connective tissue
525:Epithelial-mesenchymal transition
2466:
2454:
2001:
2000:
1576: This article incorporates
1571:
1079:
697:responses upon the detection of
533:Hypermobility as a result of an
399:
223:
214:
2358:Dense regular connective tissue
1465:Journal of Biological Chemistry
1452:
1403:
1356:
1261:
1236:
1128:"Granulation Tissue Definition"
1120:
1073:
758:Mixed connective tissue disease
620:—or structural support—for the
563:Dense regular connective tissue
493:Elastic microfibril and elastin
1616:Overview, University of Kansas
1046:
1019:
963:
920:
903:
112:. It develops mostly from the
1:
135:, membranes that envelop the
1428:10.1016/j.numecd.2006.10.005
1363:Xu, H.; et al. (2008).
792:disease of the blood vessels
780:, caused by a deficiency of
772:Systemic lupus erythematosus
360:
200:) was introduced in 1830 by
7:
1517:Histology: A Text and Atlas
1298:"Membranes | SEER Training"
798:
720:Connective tissue neoplasms
518:
251:reticular connective tissue
10:
2507:
1513:Ross M, Pawlina W (2011).
708:
522:
388:that line joint cavities.
2410:
2387:
2331:
2296:
2287:
2280:
2198:
2180:
2169:
2142:
2101:
2092:
2085:
2059:
1996:
1714:
1681:
1248:courses.lumenlearning.com
1168:. StatPearls Publishing.
929:The Histochemical Journal
711:Connective tissue disease
404:Fiber types found in the
293:Special connective tissue
288:Special connective tissue
75:
63:
51:
46:
26:
21:
1621:26 December 2010 at the
1589:Anatomy & Physiology
1459:Di Lullo; G. A. (2002).
1302:training.seer.cancer.gov
1028:"The Connective Tissues"
864:Anatomy & Physiology
640:mucous connective tissue
477:Alpha polypeptide chains
241:Connective tissue proper
236:Connective tissue proper
207:
1322:Ushiki, T (June 2002).
909:Mathews, M. B. (1975).
788:Fibromuscular dysplasia
752:Myxomatous degeneration
351:fluid connective tissue
260:dense connective tissue
246:loose connective tissue
1478:10.1074/jbc.M110709200
885:"5.3.4: Fluid Tissues"
831:"4.1 Types of Tissues"
746:Ehlers-Danlos Syndrome
538:
279:, is characterized by
196:
77:Anatomical terminology
705:Clinical significance
532:
496:extracellular matrix
202:Johannes Peter Müller
1580:available under the
1274:Online Biology Notes
972:"Connective Tissues"
816:Notes and references
659:white adipose tissue
406:extracellular matrix
1913:Meristematic tissue
1381:10.1263/jbb.106.515
1341:10.1679/aohc.65.109
1138:on 16 November 2018
1055:"Connective Tisues"
760:– a disease of the
738:Congenital diseases
646:, found inside the
634:that is capable of
549:, formed mainly by
451:
116:, derived from the
1675:Biological tissues
1034:on 31 October 2012
970:Shostak, Stanley.
941:10.1007/BF01005055
889:Biology LibreTexts
734:in nervous tissue.
728:hemangiopericytoma
539:
449:
426:glycosaminoglycans
386:synovial membranes
325:granulation tissue
2491:Connective tissue
2442:
2441:
2438:
2437:
2383:
2382:
2276:
2275:
2272:
2271:
2165:
2164:
2053:Connective tissue
2019:
2018:
1806:Phloem parenchyma
1598:978-1-947172-04-3
1162:"Anatomy, Fascia"
1082:"Histology Intro"
1061:on 6 January 2013
762:autoimmune system
516:
515:
509:Type III collagen
370:epithelial tissue
347:connective tissue
263:(subdivided into
102:epithelial tissue
94:Connective tissue
91:
90:
86:
22:Connective tissue
2498:
2471:
2470:
2469:
2459:
2458:
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2294:
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2213:Reticular fibers
2182:Ground substance
2178:
2177:
2099:
2098:
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2089:
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2004:
2003:
1954:Vascular cambium
1840:Xylem parenchyma
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1212:10.1002/ca.23423
1200:Clinical Anatomy
1191:
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1143:
1134:. Archived from
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1099:
1093:
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1077:
1071:
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1057:. Archived from
1053:Caceci, Thomas.
1050:
1044:
1043:
1041:
1039:
1030:. Archived from
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1016:
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610:reticular fibers
502:Reticular fibers
452:
450:Types of fibers
448:
422:Ground substance
418:reticular fibers
394:serous membranes
390:Mucous membranes
227:
218:
199:
153:ground substance
83:edit on Wikidata
80:
31:
19:
18:
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2144:Wandering cells
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2015:
1992:
1925:Ground meristem
1784:Vascular tissue
1755:Subsidiary cell
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1623:Wayback Machine
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742:Marfan syndrome
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644:Wharton's jelly
636:differentiation
614:reticular cells
595:ligamenta flava
555:collagen fibers
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521:
470:Collagen fibers
444:Type I collagen
410:collagen fibers
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321:muscular tissue
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1557:978-0702047473
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1532:978-0781772006
1531:
1492:
1471:(6): 4223–31.
1451:
1422:(2): 125–139.
1402:
1375:(6): 515–527.
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1206:(7): 929–933.
1186:
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1026:Potter, Hugh.
1018:
1005:978-1582557243
1004:
984:
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935:(3): 341–396.
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648:umbilical cord
583:Elastic fibers
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434:adipose tissue
414:elastic fibers
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333:fascial system
317:areolar tissue
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255:adipose tissue
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129:nervous system
110:nervous tissue
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1850:Ground tissue
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1724:Dermal tissue
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1334:(2): 109–26.
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1080:King, David.
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891:. 21 May 2021
890:
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623:
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611:
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603:
602:hematopoietic
598:
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584:
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447:
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439:
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431:
430:proteoglycans
427:
423:
419:
415:
411:
407:
400:Fibrous types
397:
395:
391:
387:
383:
379:
375:
371:
367:
358:
356:
355:liquid fascia
352:
348:
345:
340:
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337:liquid fascia
334:
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322:
318:
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306:
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298:
294:
285:
282:
278:
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266:
265:dense regular
262:
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158:
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146:
142:
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134:
130:
126:
123:
120:, the middle
119:
115:
111:
107:
106:muscle tissue
103:
100:, along with
99:
98:animal tissue
95:
84:
78:
74:
71:
68:
66:
62:
59:
56:
54:
50:
45:
40:
36:
30:
25:
20:
2478:
2190:Tissue fluid
2052:
1985:
1966:
1962:
1949:Cork cambium
1941:
1917:
1911:
1892:Sclerenchyma
1890:
1883:
1867:Chlorenchyma
1854:
1848:
1817:
1801:Phloem fiber
1788:
1782:
1761:
1727:
1723:
1690:
1588:
1570:
1566:
1547:
1541:
1516:
1468:
1464:
1454:
1419:
1415:
1405:
1372:
1368:
1358:
1331:
1327:
1317:
1305:. Retrieved
1301:
1277:. Retrieved
1273:
1263:
1251:. Retrieved
1247:
1238:
1203:
1199:
1189:
1177:. Retrieved
1165:
1140:. Retrieved
1136:the original
1131:
1122:
1110:. Retrieved
1106:
1097:
1085:. Retrieved
1075:
1063:. Retrieved
1059:the original
1048:
1036:. Retrieved
1032:the original
1021:
1009:. Retrieved
994:
987:
975:. Retrieved
965:
932:
928:
922:
910:
905:
893:. Retrieved
888:
879:
868:, retrieved
863:
834:. Retrieved
824:
714:
691:inflammatory
683:plasma cells
652:
639:
626:
616:provide the
599:
585:, made from
540:
442:
403:
364:
354:
350:
346:
343:
341:
336:
332:
295:consists of
292:
291:
258:
244:
243:consists of
240:
239:
231:
193:
131:. The three
93:
92:
2412:Specialized
2402:Mesenchymal
2373:Aponeurosis
2124:Tendon cell
2086:Composition
2067:Soft tissue
1885:Collenchyma
1835:Xylem fiber
810:Parametrium
805:Endometrium
687:eosinophils
675:macrophages
575:aponeuroses
559:capillaries
551:fibroblasts
382:spinal cord
249:(including
197:Bindegewebe
181:macrophages
173:fibroblasts
141:spinal cord
47:Identifiers
33:Section of
2157:Macrophage
2134:Melanocyte
2109:Fibroblast
2060:Physiology
1974:Endodermis
1930:Procambium
1862:Aerenchyma
1856:Parenchyma
1811:Sieve tube
1774:Phelloderm
1745:Guard cell
1696:Epithelial
1691:Connective
1166:StatPearls
1112:11 October
1087:9 December
1065:9 December
1038:9 December
977:9 December
722:including
679:mast cells
628:Mesenchyme
622:parenchyma
523:See also:
461:Components
436:(fat) and
344:supportive
189:leukocytes
185:mast cells
177:adipocytes
169:body water
125:germ layer
114:mesenchyme
39:epithelium
35:epididymis
2420:Cartilage
2389:Embryonic
2346:Submucosa
2306:Reticular
2235:Fibrillin
2152:Mast cell
2129:Adipocyte
2114:Fibrocyte
2011:Histology
1979:Exodermis
1943:Secondary
1935:Protoderm
1872:Mesophyll
1729:Epidermis
1582:CC BY 4.0
782:vitamin C
667:cartilage
642:known as
608:tissues,
606:lymphatic
591:fibrillin
571:ligaments
464:Location
366:Membranes
361:Membranes
297:cartilage
277:ligaments
122:embryonic
2485:Category
2473:Medicine
2363:Ligament
2102:Resident
2077:Scarring
2072:Fibrosis
2006:Category
1903:Sclereid
1825:Tracheid
1763:Periderm
1701:Muscular
1619:Archived
1584:license.
1487:11704682
1446:17270403
1389:19134545
1350:12164335
1307:3 August
1279:16 April
1253:16 April
1230:31183880
1179:3 August
1174:29630284
957:22765625
895:2 August
870:16 April
799:See also
740:include
726:such as
724:sarcomas
699:antigens
612:made by
519:Function
374:meninges
313:lymphoid
281:collagen
133:meninges
118:mesoderm
41:(purple)
2461:Biology
2447:Portals
2311:Adipose
2262:Elaunin
2257:EMILIN1
2230:Elastin
1919:Primary
1769:Phellem
1740:Cuticle
1706:Nervous
1683:Animals
1437:4426988
1397:3294995
1221:6852276
1132:Memidex
949:7019165
836:30 July
764:, also
632:embryos
587:elastin
567:tendons
458:Purpose
331:in the
273:tendons
145:elastic
58:D003238
2397:Mucoid
2368:Tendon
2351:Dermis
2289:Proper
2218:COL3A1
2200:Fibers
2173:matrix
1968:Cortex
1790:Phloem
1716:Plants
1595:
1554:
1529:
1485:
1444:
1434:
1395:
1387:
1348:
1228:
1218:
1172:
1011:11 May
1002:
955:
947:
778:Scurvy
695:immune
685:, and
618:stroma
579:cornea
455:Tissue
416:, and
384:) and
353:, and
329:fascia
257:) and
163:, and
155:, and
108:, and
2430:Blood
2333:Dense
2321:White
2316:Brown
2298:Loose
2281:Types
2094:Cells
1987:Stele
1963:Mixed
1898:Fiber
1819:Xylem
1525:–97.
1393:S2CID
1142:7 May
953:S2CID
790:is a
663:blood
655:brown
543:Loose
438:blood
378:brain
309:lymph
305:blood
208:Types
165:lymph
161:Blood
157:cells
137:brain
81:[
70:96404
2425:Bone
2250:FBN3
2245:FBN2
2240:FBN1
1877:Pith
1593:ISBN
1578:text
1552:ISBN
1527:ISBN
1483:PMID
1442:PMID
1385:PMID
1346:PMID
1309:2022
1281:2021
1255:2021
1226:PMID
1181:2022
1170:PMID
1144:2016
1114:2018
1089:2012
1067:2012
1040:2012
1013:2011
1000:ISBN
979:2012
945:PMID
915:link
897:2022
872:2021
838:2022
744:and
730:and
693:and
671:bone
669:and
657:and
604:and
589:and
573:and
553:and
545:and
428:and
408:are
392:and
380:and
307:and
301:bone
275:and
267:and
253:and
187:and
147:and
139:and
53:MeSH
1523:158
1473:doi
1469:277
1432:PMC
1424:doi
1377:doi
1373:106
1336:doi
1216:PMC
1208:doi
937:doi
600:In
65:FMA
2487::
1965::
1916::
1853::
1787::
1726::
1495:^
1481:.
1467:.
1463:.
1440:.
1430:.
1420:17
1418:.
1414:.
1391:.
1383:.
1371:.
1367:.
1344:.
1332:65
1330:.
1326:.
1300:.
1289:^
1272:.
1246:.
1224:.
1214:.
1204:32
1202:.
1198:.
1164:.
1152:^
1130:.
1105:.
951:.
943:.
933:13
931:.
887:.
862:,
846:^
701:.
681:,
677:,
665:,
661:,
597:.
581:.
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420:.
412:,
357:.
339:.
303:,
299:,
191:.
183:,
179:,
175:,
159:.
151:,
104:,
2449::
2045:e
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1560:.
1535:.
1489:.
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899:.
840:.
768:.
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537:.
85:]
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