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Latrodectism

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59: 29: 2450: 2474: 2462: 313:) and through the cell's signalling protein (calcium-independent receptor of alpha-latrotoxin CIRL). Thus initial pain is often followed by severe muscle cramps. Contraction of musculature may extend throughout the body, though cramping in the abdomen is frequently the most severe. Latrotoxin may act on muscles directly preventing relaxation, promoting 425:
occur usually because of accidental contact with the spiders. The species are not aggressive to humans naturally, but may bite when trapped. As such, bite incidents may be described as accidents. Reports of epidemics were associated with agricultural areas in Europe in the last two centuries. However
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is administered. Antivenom historically completely resolves pain in a short time. Antivenom is made by injecting horses with latrodectus venom over a period of time. The horse develops antibodies against the venom. The horse is bled and the antibodies purified for later use. Doctors recommend the use
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A few people go on to have widespread symptoms. Pain typically starts at the bite site then travels up (e.g. from foot to thigh to trunk), followed by generalized pain (in back, trunk, chest or shoulder). The venom directly affects nerves leading to the unusual feature of severe sweating, which may
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may not inject any venom (known as a dry bite) and so no illness occurs. About 75% of "wet" bites will have localized pain and nothing more. If, however, there is a substantial dose, a bite can cause latrodectism. The main symptoms are generalized muscle pain, stomach cramps, nausea and vomiting.
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Isbister, Geoffrey K.; Page, Colin B.; Buckley, Nicholas A.; Fatovich, Daniel M.; Pascu, Ovidiu; MacDonald, Stephen P.J.; Calver, Leonie A.; Brown, Simon G.A. (December 2014). "Randomized Controlled Trial of Intravenous Antivenom Versus Placebo for Latrodectism: The Second Redback Antivenom
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The vast majority of victims fully recover without significant lasting problems. Death from latrodectism is rare and primarily occurs in adults with cardiovascular disease or children. In the United States, where antivenom is rarely used, there have been no deaths reported for decades.
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Dart, Richard C.; Bush, Sean P.; Heard, Kennon; et al. (September 2019). "The Efficacy of Antivenin Latrodectus (Black Widow) Equine Immune F(abʹ)2 Versus Placebo in the Treatment of Latrodectism: A Randomized, Double-Blind, Placebo-Controlled, Clinical Trial".
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Despite a frequent reference to youth and old age being predisposing factors, it has been demonstrated that young children appear to be at the lowest risk for a serious bite, perhaps owing to the rapid use of antivenom. Bite victims who are very young, old,
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Shackleford, Rodney; Veillon, Diana; Maxwell, Nicole; LaChance, Lisa; Jusino, Tamara; Cotelingam, James; Carrington, Patrick (March 2015). "The black widow spider bite: differential diagnosis, clinical manifestations, and treatment options".
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In Perth, Australia, for example there were 156 bites in children from redback spiders over 20 years. Twice as many boys were bitten as girls, mostly toddlers. A third of the children developed latrodectism and there were no deaths.
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the European spider is associated with fields and humans come in contact only during harvest. For example, in the 1950s researchers believed that three bites happened each year and with an epidemic up to 180 each year.
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have also recovered quickly. Antivenom is used widely in Australia for redback bites; however, in the United States, it is less commonly used. Antivenom made from spider bite survivors has been used since the 1920s.
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People who have been bitten by a black widow spider are recommended to seek professional medical assistance for symptoms. Symptoms self-resolve in hours to days in a majority of bites without medical intervention.
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spider. Overdiagnosis is a risk, without a spider to identify. However, without a history of contact, the diagnosis may be missed as symptoms overlap with a variety of other serious clinical syndromes such as
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of anti-inflammatory medications before antivenom administration, because antivenom can induce allergic reactions to the horse proteins. The efficacy of antivenom has come under scrutiny as patients receiving
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in the United States each year. Of the bites reported in the United States from 2001 to 2005, approximately 31% were treated in a health care facility, 0.5% had major complications, and none were fatal.
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Initially a pinprick or burning sensation can be felt when bitten by widow spiders. If there was enough venom injected, pain worsens over the next hour. The area will develop localized sweating and
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Symptoms may wax and wane over the next one to four days. Rarely, patients may feel unwell for up to a week. Very rarely, untreated patients report ongoing bite site pain that last weeks or months.
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Intense local pain develops 5–10 minutes after the bite and is followed by sweating and piloerection (goosebumps) within an hour. Neither puncture marks nor redness are necessarily seen.
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Isbister, G.K.; Brown, S.G.A.; Miller, M.; Tankel, A.; Macdonald, E.; Stokes, B.; Ellis, R.; Nagree, Y.; Wilkes, G.J.; James, R.; Short, A.; Holdgate, A. (4 March 2008).
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Krasnoperov, V. G.; Bittner, M. A.; Beavis, R; Kuang, Y; Salnikow, K. V.; Chepurny, O. G.; Little, A. R.; Plotnikov, A. N.; Wu, D; Holz, R. W.; Petrenko, A. G. (1997).
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There are no tests required to diagnose widow spider bites, or latrodectism symptoms. The diagnosis is clinical and based on historic evidence of widow spider bites.
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During pregnancy the pain and abdominal cramps may be confused with other conditions. A case of preterm labor initiated by a redback spider was relieved by antivenom.
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Early medical reports of latrodectism were described in men using outhouses. The genitals were often the site of the bite. No direct injury to site is reported.
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Prongay, R; Kelsberg, G; Safranek, S (November 2012). "Clinical inquiry: which treatments relieve painful muscle spasms from a black widow spider bite?".
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Spider venoms are a complex collection of toxic agents. Unique to the widows is latrotoxin. The venom acts on nerves causing the massive release of the
1842: 1529: 930: 309:. The release of these neurotransmitters leads to pain, cramps, sweating and fast pulse. Latrotoxin acts on presynaptic nerve membranes (See 429:
Conversely, redback and North American black widows live in proximity with people and several hundred black widow bites are reported to
2509: 2388: 231:. The pain may spread and become generalized. The typical duration is three to six days. Rarely, some people who do not receive 873: 563: 780:
KNOX, IAN, and DON CAVE. "Premature labor precipitated by red‐back spider envenomation." Emergency Medicine 5.1 (1993): 3–5.
687: 1522: 366:) have been discovered to be useless. Currently, treatment usually involves symptomatic therapy with pain medication, 1959: 2478: 2273: 1515: 624: 607: 2091: 2086: 758: 741: 273:(inflammation of the heart muscle) has been associated with one medically reported death in the last 50 years. 2358: 2096: 1784: 413:, pregnant, or who have existing heart problems are reported to be the most likely to develop complications. 350:. Blood values are typically unimportant but may be needed to show myocarditis or dehydration from vomiting. 2514: 1914: 1085:"A randomised controlled trial of intramuscular vs. intravenous antivenom for latrodectism--the RAVE study" 147: 2466: 2081: 1501: 248:
be regional (e.g. one leg). Changes in adrenaline can lead to mild increase in blood pressure and pulse.
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Non-specific features of latrodectism include headache, nausea, vomiting and feeling ill and weak.
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MEAD, H. J.; JELINEK, G. A. (August 1993). "Red-back spider bites to Perth children, 1979–1988".
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provide evidence of envenomation. Diagnosis in most people includes reporting contact with a
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Mead H. J., Jelinek G. A. (1993). "Red-back spider bites to Perth children, 1979-1988".
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Vetter Richard S., Isbister Geoffrey K. (2008). "Medical aspects of spider bites".
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González Valverde FM; et al. (2001). "Fatal latrodectism in an elderly man".
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Ushkaryov, YA; Rohou, A; Sugita, S (2008). "α-Latrotoxin and iItsReceptors".
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spiders (the black widow spider and related species). Pain, muscle rigidity,
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are not commonly associated with latrodectism including the cosmopolitan
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Medical treatments have varied over the years. Some treatments (e.g.
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Symptoms of a bite depend on the amount of venom injected. A bite of
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Bettini, Sergio (1 October 1964). "Epidemiology of latrodectism".
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Peterson, ME (November 2006). "Black widow spider envenomation".
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is generally non-toxic metal, but in large doses it can lead to
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Handbook of clinical toxicology of animal venoms and poisons
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Vetter, Richard S., et al. "Bites of widow spiders". (2013).
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Sherman Roger P.; et al. (2000). "Black widow spider (
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10.1580/1080-6032(1997)008[0226:WSELAW]2.3.CO;2
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10.1580/1080-6032(2004)15[207:arovab]2.0.co;2
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There are several spider species all named black widow:
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Bettini Sergio (1964). "Epidemiology of latrodectism".
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Parasitic infestations, stings, and bites of the skin
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Bogen Emil (1926). "Arachnidism: spider poisoning".
317:—constant, strong, and painful muscle contractions. 104: 95: 86: 83: 77: 1123: 982:"Insecticidal toxins from black widow spider venom" 788: 786: 92: 1163:The Journal of the Louisiana State Medical Society 739: 2496: 980:Rohou, A; Nield, J; Ushkaryov, YA (2007-03-15). 783: 700: 1324: 235:may have muscle weakness that lasts for weeks. 1238: 1891: 1523: 647: 645: 643: 601: 599: 597: 595: 593: 654:Clinical Techniques in Small Animal Practice 504: 1365: 539: 505:Timms, P. K.; Gibbons, R. B. (March 1986). 174:that cause latrodectism are the Australian 1530: 1516: 1464:bites / diagnosis spider bites / diagnosis 948: 946: 863: 792: 640: 590: 57: 27: 1342: 1100: 1059: 1013: 906: 757: 623: 573: 522: 651: 548:Pharmacology of Neurotransmitter Release 258: 1368:Journal of Paediatrics and Child Health 1331:Wilderness & Environmental Medicine 1281: 1198:Journal of Paediatrics and Child Health 943: 746:Wilderness & Environmental Medicine 612:Wilderness & Environmental Medicine 605: 500: 498: 121:) is the illness caused by the bite of 2497: 1511: 857: 705:) envenomation in a term pregnancy". 481:10.1146/annurev.ento.53.103106.093503 217: 202:. Several other members of the genus 2461: 807:10.1001/archinte.1926.00120290072008 495: 396:ease muscle spasm in most patients. 374:. When the pain becomes unbearable, 2473: 13: 1380:10.1111/j.1440-1754.1993.tb00518.x 1210:10.1111/j.1440-1754.1993.tb00518.x 283: 135:are the symptoms of latrodectism. 14: 2536: 2510:Toxic effects of venomous animals 1406: 1139:10.1016/j.annemergmed.2019.02.007 1052:10.1016/j.annemergmed.2014.06.006 238: 36:The southern black widow spider ( 2472: 2460: 2449: 2448: 73: 1359: 1318: 1275: 1189: 1153: 1117: 1076: 1030: 973: 923: 882: 864:Meier J, White J, eds. (1995). 848: 813: 416: 955:The Journal of Family Practice 774: 733: 694: 680: 460: 1: 1038:Evaluation (RAVE-II) Study". 1006:10.1016/j.toxicon.2006.11.021 908:10.1016/s0896-6273(00)80332-3 834:10.1016/s0025-7753(01)72100-8 795:Archives of Internal Medicine 719:10.1016/s0149-7944(00)00276-2 606:Jelinek, GA (November 1997). 1304:10.1016/0041-0101(64)90009-1 1261:10.1016/0041-0101(64)90009-1 1127:Annals of Emergency Medicine 1040:Annals of Emergency Medicine 453: 399: 353: 320: 7: 666:10.1053/j.ctsap.2006.10.003 556:10.1007/978-3-540-74805-2_7 511:Western Journal of Medicine 469:Annual Review of Entomology 441: 329:symptoms such as localized 164:Northern black widow spider 140:southern black widow spider 10: 2541: 2201:Arthropod bites and stings 1820:Nitrogen dioxide poisoning 740:Langley Ricky Lee (2004). 287: 156:Western black widow spider 42:), a cause of latrodectism 2444: 2416: 2412: 2376: 2320: 2268: 2191: 2107: 2043: 2036: 1995: 1968: 1960:Tricyclic antidepressants 1900: 1882: 1828: 1800: 1770: 1761: 1724: 1706: 1686: 1643: 1595: 1586: 1577: 1559: 1502:"Black Widow Spider Bite" 1473: 1414: 199:Latrodectus curacaviensis 190:) and the South American 46: 35: 26: 21: 1344:10.1580/07-weme-or-111.1 1325:Langley Ricky L (2008). 152:L. tredecimguttatus 2399:List of types of poison 1955:Serotonergic substances 1687:Other non-toxic metals 193:Latrodectus corallinus 2067:Ichthyoallyeinotoxism 688:"Unsupported Browser" 259:Special circumstances 1102:10.1093/qjmed/hcn048 148:European black widow 2515:Medical emergencies 2437:foodborne illnesses 2394:Lists of poisonings 2077:Shellfish poisoning 1785:Aluminium phosphide 1296:1964Txcn....2...93B 1253:1964Txcn....2...93B 998:2007Txcn...49..531R 703:Latrodectus mactans 212:L. geometricus 182:), the New Zealand 39:Latrodectus mactans 2389:EPA list of hazard 2171:Alpha-Bungarotoxin 1915:Anticholinesterase 1504:on eMedicineHealth 1474:External resources 218:Signs and symptoms 53:Emergency medicine 2525:Arthropod attacks 2492: 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2254: 2251: 2249: 2245: 2242: 2241: 2240: 2237: 2233: 2232:Charybdotoxin 2230: 2229: 2228: 2225: 2221: 2218: 2216: 2213: 2212: 2211: 2207: 2204: 2202: 2199: 2198: 2196: 2194: 2190: 2182: 2179: 2177: 2174: 2172: 2169: 2168: 2167: 2163: 2160: 2158: 2155: 2151: 2148: 2147: 2146: 2143: 2139: 2136: 2134: 2131: 2129: 2126: 2124: 2123:Batrachotoxin 2121: 2120: 2119: 2116: 2115: 2113: 2111: 2106: 2098: 2095: 2093: 2090: 2088: 2085: 2083: 2080: 2079: 2078: 2075: 2073: 2070: 2068: 2065: 2063: 2060: 2058: 2055: 2054: 2052: 2050: 2046: 2042: 2039: 2035: 2025: 2020:Megavitamin-B 2018: 2016: 2013: 2011: 2008: 2006: 2003: 2002: 2000: 1998: 1994: 1984: 1981: 1979: 1976: 1975: 1973: 1971: 1967: 1961: 1958: 1956: 1953: 1951: 1948: 1946: 1943: 1941: 1938: 1936: 1933: 1931: 1928: 1926: 1923: 1921: 1918: 1916: 1913: 1911: 1908: 1907: 1905: 1903: 1899: 1896: 1894: 1890: 1887: 1885: 1881: 1871: 1868: 1866: 1863: 1861: 1858: 1854: 1851: 1849: 1846: 1844: 1841: 1840: 1839: 1838: 1834: 1833: 1831: 1827: 1821: 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1278: 1270: 1266: 1262: 1258: 1254: 1250: 1247:(2): 93–102. 1246: 1242: 1235: 1227: 1223: 1219: 1215: 1211: 1207: 1203: 1199: 1192: 1184: 1180: 1176: 1172: 1168: 1164: 1156: 1148: 1144: 1140: 1136: 1132: 1128: 1120: 1112: 1108: 1103: 1098: 1094: 1090: 1086: 1079: 1071: 1067: 1062: 1057: 1053: 1049: 1045: 1041: 1033: 1025: 1021: 1016: 1011: 1007: 1003: 999: 995: 992:(4): 531–49. 991: 987: 983: 976: 968: 964: 961:(11): 694–5. 960: 956: 949: 947: 938: 937: 932: 926: 918: 914: 909: 904: 901:(6): 925–37. 900: 896: 892: 885: 877: 871: 868:. CRC Press. 867: 860: 851: 843: 839: 835: 831: 827: 823: 816: 808: 804: 800: 796: 789: 787: 777: 769: 765: 760: 755: 751: 747: 743: 736: 728: 724: 720: 716: 712: 708: 704: 697: 689: 683: 675: 671: 667: 663: 660:(4): 187–90. 659: 655: 648: 646: 644: 635: 631: 626: 621: 618:(4): 226–31. 617: 613: 609: 602: 600: 598: 596: 594: 585: 581: 576: 571: 567: 561: 557: 553: 549: 542: 534: 530: 525: 520: 516: 512: 508: 501: 499: 490: 486: 482: 478: 474: 470: 463: 459: 449: 446: 445: 439: 435: 432: 427: 424: 414: 412: 406: 397: 395: 391: 387: 382: 377: 373: 369: 365: 360: 351: 349: 348:acute abdomen 345: 340: 336: 332: 328: 327:Pathognomonic 318: 316: 312: 308: 304: 300: 299:acetylcholine 297: 291: 278: 275: 272: 269: 266: 263: 262: 253: 250: 246: 243: 242: 236: 234: 230: 225: 215: 213: 209: 205: 201: 200: 195: 194: 189: 185: 181: 177: 173: 169: 165: 161: 157: 153: 149: 145: 141: 136: 134: 130: 126: 125: 118: 70: 60: 54: 51: 49: 45: 41: 40: 34: 30: 25: 20: 2477: 2465: 2453: 2248:Latrodectism 2247: 2239:spider venom 2062:Haff disease 1983:Dipyridamole 1925:Barbiturates 1835: 1597:Toxic metals 1481: 1457: 1442: 1427: 1371: 1367: 1361: 1334: 1330: 1320: 1287: 1283: 1277: 1244: 1240: 1234: 1201: 1197: 1191: 1169:(2): 74–78. 1166: 1162: 1155: 1130: 1126: 1119: 1092: 1088: 1078: 1043: 1039: 1032: 989: 985: 975: 958: 954: 934: 925: 898: 894: 884: 865: 859: 850: 825: 821: 815: 798: 794: 776: 749: 745: 735: 710: 706: 702: 696: 682: 657: 653: 615: 611: 547: 541: 514: 510: 472: 468: 462: 436: 428: 422: 420: 417:Epidemiology 407: 403: 361: 357: 338: 335:piloerection 324: 293: 223: 221: 211: 203: 197: 191: 187: 179: 171: 167: 159: 151: 143: 137: 122: 69:Latrodectism 68: 67: 37: 22:Latrodectism 2505:Latrodectus 2479:WikiProject 2292:Fish toxins 2253:Loxoscelism 2166:Snake venom 2138:Physalaemin 2110:vertebrates 1950:Paracetamol 1337:(1): 7–14. 936:Mayo Clinic 475:: 409–429. 448:Loxoscelism 423:Latrodectus 421:Bites from 411:hypotensive 339:Latrodectus 271:Myocarditis 224:Latrodectus 208:brown widow 204:Latrodectus 172:Latrodectus 124:Latrodectus 2499:Categories 2427:including 2384:Antibiotic 2312:Strychnine 2282:Cinchonism 2244:Latrotoxin 2193:Arthropods 2181:Batroxobin 2092:Neurotoxic 2087:Diarrhetic 2037:Biological 1780:Pesticides 1772:Phosphorus 1708:Metalloids 1061:2123/14928 828:(8): 319. 290:Latrotoxin 288:See also: 229:goosebumps 2404:Pollution 2344:Cnidocyte 2297:Lathyrism 2210:Bee venom 2206:Bee sting 2150:Coturnism 2133:Bufotenin 2118:Amphibian 2097:Paralytic 2072:Scombroid 2057:Ciguatera 2015:Vitamin E 2010:Vitamin D 2005:Vitamin A 1726:Nonmetals 1673:Manganese 1605:Beryllium 1579:Inorganic 1541:Poisoning 1483:eMedicine 1175:0024-6921 454:Footnotes 400:Prognosis 376:antivenom 372:antivenom 354:Treatment 321:Diagnosis 233:antivenom 170:). Other 48:Specialty 2455:Category 2307:Mushroom 2287:Ergotism 2272: / 2246: / 2220:Melittin 2208: / 2164: / 2128:Bombesin 2047: / 2024:syndrome 1853:Methanol 1815:Nicotine 1802:Nitrogen 1749:Fluoride 1744:Chlorine 1739:Selenium 1653:Chromium 1630:Thallium 1551:Overdose 1546:Toxicity 1488:derm/599 1396:25640556 1353:18333665 1312:14301291 1269:14301291 1226:25640556 1183:25978056 1147:30926190 1111:18400776 1070:24999282 1024:17210168 967:23256102 842:11571130 768:15473462 727:11024247 674:17265903 634:11990169 584:18064415 489:17877450 442:See also 390:morphine 388:such as 331:sweating 186:spider ( 133:sweating 129:vomiting 2467:Commons 2423:argyria 2332:Stinger 2302:Locoism 2082:Amnesic 2049:Seafood 1978:Digoxin 1945:Opioids 1940:Lithium 1935:Cocaine 1920:Aspirin 1910:Alcohol 1902:Nervous 1870:Toluene 1843:Ethanol 1837:alcohol 1810:Cyanide 1763:Organic 1716:Arsenic 1620:Mercury 1610:Cadmium 1569:History 1388:8373679 1292:Bibcode 1284:Toxicon 1249:Bibcode 1241:Toxicon 1218:8373679 1015:2517654 994:Bibcode 986:Toxicon 917:9208860 575:2519134 533:3962294 524:1306604 386:Opioids 381:placebo 344:tetanus 146:), the 2433:toxins 2429:venoms 2419:Silver 2270:Plants 2215:Apamin 2176:Ancrod 2162:Snakes 2157:Mammal 2108:Other 1865:Oxygen 1694:Silver 1663:Copper 1658:Cobalt 1625:Nickel 1588:Metals 1564:Poison 1394:  1386:  1351:  1310:  1267:  1224:  1216:  1181:  1173:  1145:  1109:  1068:  1022:  1012:  965:  915:  895:Neuron 872:  840:  766:  725:  672:  632:  582:  572:  562:  531:  521:  487:  370:, and 315:tetany 305:, and 184:katipō 131:, and 55:  2337:plant 2274:Fungi 2145:Birds 1453:989.5 1438:T63.3 1392:S2CID 1222:S2CID 2330:and 2328:Bite 2045:Fish 1678:Zinc 1668:Iron 1615:Lead 1459:MeSH 1448:9-CM 1384:PMID 1349:PMID 1308:PMID 1265:PMID 1214:PMID 1179:PMID 1171:ISSN 1143:PMID 1107:PMID 1066:PMID 1020:PMID 963:PMID 913:PMID 870:ISBN 838:PMID 764:PMID 723:PMID 670:PMID 630:PMID 580:PMID 560:ISBN 529:PMID 485:PMID 333:and 307:GABA 196:and 1829:CHO 1635:Tin 1444:ICD 1429:ICD 1376:doi 1339:doi 1300:doi 1257:doi 1206:doi 1167:167 1135:doi 1097:doi 1093:101 1089:QJM 1056:hdl 1048:doi 1010:PMC 1002:doi 903:doi 830:doi 826:117 803:doi 754:doi 715:doi 662:doi 620:doi 570:PMC 552:doi 519:PMC 515:144 477:doi 346:or 214:). 162:), 154:), 2501:: 2435:, 2431:, 1486:: 1462:: 1451:: 1436:: 1433:10 1390:. 1382:. 1372:29 1370:. 1347:. 1335:19 1333:. 1329:. 1306:. 1298:. 1286:. 1263:. 1255:. 1243:. 1220:. 1212:. 1202:29 1200:. 1177:. 1165:. 1141:. 1131:74 1129:. 1105:. 1091:. 1087:. 1064:. 1054:. 1044:64 1042:. 1018:. 1008:. 1000:. 990:49 988:. 984:. 959:61 957:. 945:^ 933:. 911:. 899:18 897:. 893:. 836:. 824:. 799:38 797:. 785:^ 762:. 750:15 748:. 744:. 721:. 711:57 709:. 668:. 658:21 656:. 642:^ 628:. 614:. 610:. 592:^ 578:. 568:. 558:. 527:. 513:. 509:. 497:^ 483:. 473:53 471:. 301:, 114:əm 2439:. 2022:6 1531:e 1524:t 1517:v 1446:- 1431:- 1421:D 1398:. 1378:: 1355:. 1341:: 1314:. 1302:: 1294:: 1288:2 1271:. 1259:: 1251:: 1245:2 1228:. 1208:: 1185:. 1149:. 1137:: 1113:. 1099:: 1072:. 1058:: 1050:: 1026:. 1004:: 996:: 969:. 939:. 919:. 905:: 878:. 844:. 832:: 809:. 805:: 770:. 756:: 729:. 717:: 690:. 676:. 664:: 636:. 622:: 616:8 586:. 554:: 535:. 491:. 479:: 210:( 178:( 166:( 158:( 150:( 142:( 117:/ 111:z 108:ɪ 105:t 102:k 99:ɛ 96:d 93:ˈ 90:ə 87:r 84:t 81:æ 78:l 75:/ 71:(

Index


Latrodectus mactans
Specialty
Emergency medicine
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/lætrəˈdɛktɪzəm/
Latrodectus
vomiting
sweating
southern black widow spider
European black widow
Western black widow spider
Northern black widow spider
redback spider
katipō
Latrodectus corallinus
Latrodectus curacaviensis
brown widow
goosebumps
antivenom
Myocarditis
Rhabdomyolysis
Latrotoxin
neurotransmitters
acetylcholine
norepinephrine
GABA
Chemical synapse
tetany
Pathognomonic

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