552:
infectious among healthy volunteers. There was no evidence whether the pathogen in B814 was a bacterium or a virus as all bacterial and viral culture methods available showed negative results. In the early 1965, while visiting the
University of Lund in Sweden to receive a honorary doctorate, Andrewes learned of Bertil Hoorn who had developed a culture method for viruses using human trachea tissue. Hoorn had successfully cultured influenza viruses. After learning about these developments from Andrewes, Tyrrell invited Hoorn to visit CCRU. Using the new culture method, they were able to grow many viruses which could not be maintained in other culture methods.
383:, was reported that exhibited almost similar symptoms but mostly affected adult chickens. As Beaudette later recalled in 1937, the disease he described was infectious layngotracheitis, saying: "Infectious laryngotracheitis is said to be the correct name for this disease rather than infectious bronchitis… Moreover, the gasping symptom ordinarily accepted as typical of the disease is also a prominent symptom in infectious bronchitis (gasping disease, chick bronchitis)." The names infectious bronchitis and infectious laryngotracheitis were till then used synonymously and interchangeably.
1322:
974:. SARS-CoV emerged as an acute respiratory syndrome in Guangdong Province, southern China, during 16 November 2002 to 28 February 2003. The syndrome was accompanied by pneumonia that was fatal in many cases. The infection was believed to have been contained in China, but an infected individual carried it to Hong Kong on 21 February and spread it in the hotel and hospital. The first clinical case outside China was reported on 26 February 2003 in Hanoi, Viet Nam. It rapidly spread to Southeast Asia, North America and Europe. The
686:, Canada, Almeida had developed two unique techniques for electron microscopy of viruses: the first was a modified negative staining method using phosphotungstic acid, and the next was immunological procedure in which she reacted viruses with antibodies (antigen-antibody complexes). Employing these techniques, she had successfully identified IBV and MHV as structurally distinct viruses, but her manuscript was rejected upon a referee's decision that the images were probably of influenza virus, and thus, lacked novelty.
613:
509:, Bethesda, reported the discovery of a new virus (designated as MHV-A59) from murine leukemia virus-infected mice, remarking that it was a member of the hepatoencephalitis group. The virus primary cause fatal hepatitis and encephalitis. Pneumonia-causing rat coronavirus (RCV) discovered in 1970, and sialodacryoadenitis virus (SDAV), which infects nasal cavities, lungs, salivary glands and the Harderian gland in rats, discovered in 1972 were found to be the same kind of hepatoencephalitis viruses.
31:
663:
1308:), cattle (Bovine coronavirus), and human (HCoV-OC43) share over 98% similarities, suggesting their common origin from a single host. There is an evidence that HCoV-OC43 came from cattle around 1890, which makes it likely the first zoonotic coronavirus. Although no details are yet available, but it is generally believed that MERS-CoV originated from bat coronavirus and specifically suggested to have evolved from the common ancestor of BtCoV-HKU4 and BtCoV-HKU5, under the genus
347:
706:
1312:. Genetic estimate indicates that SARS-CoV-2 evolved from bat coronavirus in around 1948. Another estimate suggests SARS-CoV-2 shares a common ancestor with bat coronavirus RmYN02 in about 1976. SARS-CoV also possibly originated in around 1962 from the same horseshoe bats that harbours SARS-like coronaviruses. It was transmitted humans in around 1998 (4.08 years prior to the outbreak in 2003).
759:
is shared by mouse hepatitis virus and several viruses recently recovered from man, namely strain B814, 229E and several others... In the opinion of the eight virologists these viruses are members of a previously unrecognized group which they suggest should be called the coronaviruses, to recall the characteristic appearance by which these viruses are identified in the electron microscope.
395:) as the main organ affected was the bronchi. The bronchi infection resulted in severe gasping and swift death due to inability to eat food. It was also found that the pathogens could not be bacteria or protozoans as they passed through membranes (Berkefield filter) that would block those pathogens. The isolation and identification of the pathogen as a virus was reported as:
1130:, which was characterised mainly by diarrhoea and vomiting and associated with high mortality, was first recognised by Leo Philip Doyle and Leslie Morton Hutchings of the Purdue University in Indiana, US, in 1946. Arlan W. McClurkin at the National Animal Disease Center, US Department of Agriculture in Iowa, isolated and identified the virus in 1965. The virus was named
548:
called H strain, could be maintained only in human-embryo-kidney cell culture, and another group, designated M strain, could be maintained both in human-embryo-kidney cell culture and monkey-embryo-kidney cell culture. By then many common cold viruses could be grown in either of these cell cultures and were accordingly classified as M or H strain.
718:
number of specimen in organ culture) were particularly virulent and caused encephalitis in experimental mice. They compared the structure of one of their samples numbered 501 (OC43) with those of 229E, IBV and influenza virus. It was so identical to IBV that they called the human viruses as "IBV-like viruses". They made a definitive description as:
471:). The mice had no visible illness or diarrhoea, which usually are associated with murine encephalitis. In addition, the causative virus was isolated from different organs including liver, spleen, lungs, and kidneys. This indicated that brain was not the primary target organ. Liver was particularly affected with severe tissue damage (
505:, Bethesda, discovered a new mouse virus, which he named H747, from samples in Japan. When he compared the virus with JHM and MHV using serological tests, he found that they were both antigenically related, for which he created a common name "hepatoencephalitis group of murine viruses." In 1961, Robert A. Manaker and his team at the
1111:) from Bisha, Saudi Arabia, indicating its original source. In 2014, it was established that the virus was transmitted to humans by dromedary camels, which act as the intermediate hosts. By December 2019, the infection was confirmed in 2,499 individuals with 858 deaths (34.3% mortality) from 27 countries covering all continents.
591:. In 1962, they obtained five samples that were associated with very different symptoms, causing mild cold only, and could be cultured only in secondary human kidney tissue in contrast to other cold viruses which could be maintained in monkey-embryo-kidney cell culture. Serological test indicated they were not myxoviruses (
942:
was discovered from a 71-year-old man in Hong Kong, China, who was suffering from pneumonia in
January 2004. When samples (nasopharyngeal aspirates from pneumonia patients) collected between April 2004 to March 2005 were analysed in 2006, it was found that 13 individuals had HCoV-HKU1. The same year,
399:
In several experiments we have reproduced the disease in chicks by the intratracheal, subcutaneous and intraperitoneal injection of
Berkefeld filtered material. The chicks developed typical gasping symptoms after various periods of incubation, different groups of chicks first showing symptoms in six,
1236:
50 percent of the bats exposed to the infectious bronchitis virus showed symptoms or death in the intracerebral, intraperitoneal, intradermal, intracardiac and intraocular groups; 75 percent in the intranasal and intrarectal groups; 100 percent in the intraoral group; and 25 percent intralingual and
645:
published a more comprehensive and better electron microscopic images in 1964. Four strains of IBV, including
Beaudette strain, were compared with influenza virus, with which they share most resemblance. In contrast to influenza virus in which the projections were small and straight, all IBV strains
555:
Then B814 could be maintained in the new human tracheal culture and experimentally passed on to healthy volunteers by nasal inoculation. It was possible to confirm the nature of the pathogen as a filter-passing virus as it was susceptible to ether treatment (indicating a lipid-enveloped virus), able
309:
Other coronaviruses have been discovered from pigs, dogs, cats, rodents, cows, horses, camels, Beluga whales, birds and bats. As of 2022, 52 species are described. Bats are found to be the richest source of different species of coronaviruses. All coronaviruses originated from a common ancestor about
1195:
was first known in
England in 1971 and was specifically among fattening pigs and sows. It was referred to as TOO (for "the other one") or TGE2 (for "transmissible gastroenteritis type 2") as the symptoms were similar to transmissible gastroenteritis. Other than causing rapid and acute diarrhoea, it
1096:
in
Rotterdam, the Netherlands, where it was identified). Retrospective study of samples from the Jordan hospital revealed that the diseases and the virus were similar. WHO referred to the virus as the Middle East respiratory syndrome coronavirus (MERS-CoV) on 23 May 2013., which the ICTV adopted on
758:
Particles are more or less rounded in profile; although there is a certain amount of polymorphism, there is also a characteristic "fringe" of projections 200 Å long, which are rounded or petal shaped, rather than sharp or pointed, as in the myxoviruses. This appearance, recalling the solar corona,
745:
Even though we could only base our judgement on the electron microscope images we were quite certain that we had identified a previously unrecognised group of viruses. So what should we call them? 'Influenza-like' seem a bit feeble, somewhat vague, and probably misleading. We looked more closely at
629:
that IBV was spherical in shape and some of them had filamentous projections. But the images were difficult to interpret due to poor resolution and low magnification (at × 28,000). Their subsequent studies did not show any striking properties from other viruses. An important advancement was made by
423:
It was found that chickens that recovered from an infection with one of the two strains of virus were refractory to further infection with either strain. It was also found that the sera from chickens that have recovered from an infection with one strain of the virus would neutralize virus of either
366:
that mostly affected 2-day-old to 3-week-old chickens. They referred to the disease as "an apparently new respiratory disease of baby chicks." The symptoms included severe shortness of breath and physical weakness. The infection was contagious and virulent, easily transmitted through direct contact
1027:
was known from cases of atypical pneumonia in Wuhan city, China. The Wuhan
Municipal Health Commission reported 27 individuals having "viral pneumonia" on 31 December 2019. The first known case was recorded on 12 December. The first case outside China was in Thailand on 13 January. WHO adopted the
547:
joined CCRU in 1957 and succeeded
Andrewes in 1962. He developed a technique for growing rhinoviruses using nasal epithelial cells for the first time in 1960. Based on the technique, his team soon after formulated a concept of broad categorisation of common cold viruses into two groups: one group,
1145:
at the Angell
Memorial Animal Hospital in Boston described a new intestinal disease of cats. In 1966, it was shown to cause inflammation of the abdomen in cats and was referred to as feline infectious peritonitis. Its causative virus was identified in 1968. Another cat coronavirus, feline enteric
919:
and fever. A year later, a comprehensive analysis of nasal swab samples was done from where it was found that a sample from an eight-month-old boy diagnosed in 1988 with pneumonia had a similar virus (HCoV-NL). The virus was independently described in 2005 as HCoV-NH following a discovery among a
717:
In 1967, Kenneth McIntosh and co-workers at the
National Institute of Health, Bethesda, reported the structure of common cold viruses they collected from fellow workers during 1965-1966. They found six of their samples had common characters with B814. Two samples (designated OC38 and OC43, as the
650:
These "spikes" were often seen over part of the surface only and were less densely packed than those seen in influenza viruses. They varied considerably in shape. Commonly they appeared to be attached to the virus by a very narrow neck and to thicken towards their distal ends, sometimes forming a
404:
This was the discovery of infectious bronchitis virus (IBV), the first coronavirus. But Bushnell and Brandy made an erroneous remark by saying, "The symptoms and lesions in the chicks are similar to those seen in so-called laryngotracheitis of adult birds and are probably due to the same agent."
386:
Unaware of the developments, Leland David Bushnell and Carl Alfred Brandly at the Kansas Agricultural Experiment Station studied a similar case which they called "gasping disease" due to the apparent symptom. They had known the disease since 1928. Their report in 1933 titled "Laryngotracheitis in
1211:
in 1995. An epidemic broke out from China in 2010 that spread throughout the world. A virulent strain emerged in US between 2013 and 2015. It affected pigs of all ages, and mortality was as high as 95% among the suckling piglets. Another severe outbreak occurred in Germany in 2014 that spread to
726:
with resultant elliptical, round, or tear-drop shapes but no filamentous or "tailed" forms; (3) characteristic spikes 20 mμ long, usually club- or pear-shaped narrow at the base and 10 mμ wide at the outer edge, spaced widely apart and distributed fairly uniformly about the circumference of the
1200:
in 1972 using the title "Epidemic diarrhoea – How it all began". It was similar in symptoms to those of PTGV infection, but only affected piglets. It spread to the neighbouring countries and was referred to as epidemic viral diarrhea. A second outbreak occurred in 1976, and was called "porcine
700:
Probably the most interesting finding from these experiments was that two human respiratory viruses, 229 E and B814 are morphologically identical with avian infectious bronchitis. Their biological properties, as far as they are known, are consistent with this. Both the human viruses are ether
551:
During 1960-1961, Tyrrell's team collected throat swabs from 170 school boys having common cold at a boarding school in Epsom, Surrey. England. Among few samples that could not be cultured in any of the culture media, a specimen designated B814, collected on 17 February 1961, was particularly
1241:
But nothing was known of the real nature of bats as reservoirs of coronaviruses until the epidemic of severe acute respiratory syndrome of humans in 2002/2003. Since the identification of SARS-CoV was identified in early 2003, and horseshoe bats as their natural hosts in 2005, bats have been
1091:
In April 2012, the Ministry of Health, Jordan, reported an outbreak of acute respiratory illness affecting 11 people at a hospital in Zarqa. On 13 June 2012, a 60-year-old man having the symptoms was admitted to Dr. Soliman Fakeeh Hospital in Jeddah, Saudi Arabia. He was diagnosed with acute
736:
By mid-1967 it was recognised that IBV, MHV, B814 and 229E were structurally and biologically similar so that they form a distinct group. Tyrrell met Waterson and Almeida in London to decide on the name of the viruses. Almeida had earlier suggested the term "influenza-like" because of their
689:
Tyrrell supplied the human virus samples B814 and 229E, which Almeida analysed using transmission electron microscopy. The human viruses showed the same fundamental structures with that of a chicken virus (IBV). Almeida and Tyrrell published their findings in the April 1967 issue of the
1032:; thereby rendering the new virus as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), while the former 2003 virus as SARS-CoV or SARS-CoV-1. WHO declared the infection as pandemic on 11 March, and since then has spread around the world, affecting over 676
1080:) which are available in the live-animal market in Wuhan city and whose coronavirus is genetically related to the SARS-CoV-2. Rodents are also suspected as they are susceptible the viral infection. However, no animal is so far established as an intermediate host.
427:
Chickens refractory to infection with this virus were shown to be susceptible to the virus of laryngotracheitis. Likewise, chickens refractory to the latter virus were susceptible to the former. These results demonstrate that the two viruses are distinct from one
8670:"Discovery of seven novel Mammalian and avian coronaviruses in the genus deltacoronavirus supports bat coronaviruses as the gene source of alphacoronavirus and betacoronavirus and avian coronaviruses as the gene source of gammacoronavirus and deltacoronavirus"
1052:) which are available in the live-animal market in Wuhan city has been studied as a probable source as the virus is closely related to the pangolin coronavirus. Genetic evidences show that the virus bears 93% nucleotide similarity with a novel coronavirus of
620:
Viruses cannot be seen normally with light microscopes. It was only with the development of electron microscopy that viruses could be visualised and structurally elucidated. Reginald L. Reagan, Jean E. Hauser, Mary G. Lillie, and Arthur H. Craige Jr. of the
990:
in 2009. By mid-July 2003, the infection subsided, and by then it had spread to 28 countries infecting 8096 people and causing 774 deaths. In October, in an attempt to identify the source of infection, it was found that the infection was acquired from the
412:, reexamined Bushnell and Brady's experiment with a conclusion that infectious laryngotracheitis and infectious bronchitis with their causative viruses were different. (In 1931, Beach had discovered the virus of infectious laryngotracheitis, now called
378:
in New Brunswick, New Jersey, put forth a hypothesis in 1932 that virus could be the cause and introduced the name as "virus of the infectious bronchitis." But this was a misattribution because at the time another related disease, known as
5071:
Peng, Guo-wen; He, Jian-feng; Lin, Jin-yan; Zhou, Duan-hua; Yu, De-wen; Liang, Wen-jia; Li, Ling-hui; Guo, Ru-ning; Luo, Hui-ming; Xu, Rui-heng (2003). "Epidemiological study on severe acute respiratory syndrome in Guangdong province".
450:
in Boston. Two laboratory mice (Schwenktker strains) of 17 and 18 days old had flaccid paralysis and died. It was generally believed that the mice had murine encephalitis. By then it was known that murine encephalitis was caused by a
8253:
Marra, Marco A.; Jones, Steven J. M.; Astell, Caroline R.; Holt, Robert A.; Brooks-Wilson, Angela; Butterfield, Yaron S. N.; Khattra, Jaswinder; Asano, Jennifer K.; Barber, Sarah A.; Chan, Susanna Y.; Cloutier, Alison (30 May 2003).
887:
of which seven are of humans while 45 are those of other animals such as pigs, dogs, cats, rodents, cows, horses, camels, Beluga whales, birds and bats. There are also 35 reported species which are yet to be assigned official names.
1028:
name of the disease as "coronavirus disease 2019" (COVID-19) on 11 February 2020, and used "2019 novel coronavirus" or "2019-nCoV" for the virus. On 2 March 2020, ICTV published the formal description and gave the official name as
433:
Hudson and Beaudette later in 1937 were able to culture IBV for the first time using chicken embryos. This specimen, known as the Beaudette strain, became the first coronavirus to have its genome completely sequenced in 1987.
1146:
coronavirus, was reported in 1981 as closely related to feline infectious peritonitis virus, and was subsequently found to be more common, more innocuous and principally responsible for diarrhoea. In 1991, ICTV gave the name
1303:
It is also not yet clear how coronaviruses jump from bats and birds to other animals. Some genetic evidences indicate that animal coronaviruses switch hosts from one mammal to another. For example, the coronaviruses of dog
1266:
that encodes an accessory protein. Phylogenetic analyses present contrasting estimates varying from thousands to million years. A study in 2012 suggested that the MRCA lived around 8,100 years ago. The four known genera
603:
in 1966. They further studied one sample, designated 229E, grown in human diploid cell culture (Wi-38) and described its developmental stages using transmission electron microscopy to show that it was new type of virus.
1242:
extensively studied. Among all coronavirus hosts, bats are known to harbour the most variety, with more than 30 species identified. According to diversity estimate, there may be 3,200 species of coronaviruses in bats.
1092:
pneumonia and died on 24 June due to progressive respiratory and renal failure. His sputum sample showed the presence of coronavirus very similar to bat coronaviruses HKU4 and HKU5. The virus was named HCoV-EMC (after
978:(WHO) notified an epidemic alert on 6 March 2003, referring to the disease as severe acute respiratory syndrome. The virus was identified as a novel coronavirus from Hong Kong in April, from Toronto in May, and at the
1299:
that infect birds. However, a revised analysis indicates that the MRCA that could have lived around 190 to 489 (with a mean of 293) million years ago, and separation into new groups started a few million years after.
6954:
de Groot, Raoul J.; Baker, Susan C.; Baric, Ralph S.; Brown, Caroline S.; Drosten, Christian; Enjuanes, Luis; Fouchier, Ron A. M.; Galiano, Monica; Gorbalenya, Alexander E.; Memish, Ziad A.; Perlman, Stanley (2013).
400:
seventeen, nineteen, etc., days after receiving the filtrate... The disease may also be transferred by means of filtrates of spleen, liver, and kidney tissues and by the transfer of bacteriologically sterile blood.
7061:
Memish, Ziad A.; Mishra, Nischay; Olival, Kevin J.; Fagbo, Shamsudeen F.; Kapoor, Vishal; Epstein, Jonathan H.; Alhakeem, Rafat; Durosinloun, Abdulkareem; Al Asmari, Mushabab; Islam, Ariful; Kapoor, Amit (2013).
4532:
van der Hoek, Lia; Pyrc, Krzysztof; Jebbink, Maarten F.; Vermeulen-Oost, Wilma; Berkhout, Ron J. M.; Wolthers, Katja C.; Wertheim-van Dillen, Pauline M. E.; Kaandorp, Jos; Spaargaren, Joke; Berkhout, Ben (2004).
804:
The first discovered human coronavirus B814 was antigenically different from 229E and OC43, but it could not be propagated in culture and was exhausted during experiments in 1968, thus, was excluded in taxonomy.
3216:
Reagan, R. L.; Brueckner, A. L.; Delaplane, J. P. (1950). "Morphological observations by electron microscopy of the viruses of infectious bronchitis of chickens and the chronic respiratory disease of turkeys".
233:
among chickens in North Dakota, U.S., in 1931. The causative agent was identified as a virus in 1933. By 1936, the disease and the virus were recognised as unique from other viral disease. They became known as
4502:
1153:
It was generally assumed that the two viruses were distinct types; but in 1998, it was shown that feline infectious peritonitis virus arises from feline enteric virus by spontaneous mutation. A common name,
570:
After considerable initial doubts we now believe that the B814 strain is a virus virtually unrelated to any other known virus of the human respiratory tract, although, since it is ether-labile, it may be a
7798:"The nucleotide sequence of the peplomer gene of porcine transmissible gastroenteritis virus (TGEV): comparison with the sequence of the peplomer protein of feline infectious peritonitis virus (FIPV)"
8413:
Anthony, Simon J.; Johnson, Christine K.; Greig, Denise J.; Kramer, Sarah; Che, Xiaoyu; Wells, Heather; Hicks, Allison L.; Joly, Damien O.; Wolfe, Nathan D.; Daszak, Peter; Karesh, William (2017).
4788:
Woo, Patrick C. Y.; Lau, Susanna K. P.; Chu, Chung-ming; Chan, Kwok-hung; Tsoi, Hoi-wah; Huang, Yi; Wong, Beatrice H. L.; Poon, Rosana W. S.; Cai, James J.; Luk, Wei-kwang; Poon, Leo L. M. (2005).
4739:
Huynh, Jeremy; Li, Shimena; Yount, Boyd; Smith, Alexander; Sturges, Leslie; Olsen, John C.; Nagel, Juliet; Johnson, Joshua B.; Agnihothram, Sudhakar; Gates, J. Edward; Frieman, Matthew B. (2012).
8668:
Woo, Patrick C. Y.; Lau, Susanna K. P.; Lam, Carol S. F.; Lau, Candy C. Y.; Tsang, Alan K. L.; Lau, John H. N.; Bai, Ru; Teng, Jade L. L.; Tsang, Chris C. C.; Wang, Ming; Zheng, Bo-Jian (2012).
4837:
Lau, Susanna K. P.; Woo, Patrick C. Y.; Yip, Cyril C. Y.; Tse, Herman; Tsoi, Hoi-wah; Cheng, Vincent C. C.; Lee, Paul; Tang, Bone S. F.; Cheung, Chris H. Y.; Lee, Rodney A.; So, Lok-yee (2006).
746:
the appearance of the new viruses and noticed that they had a kind of halo surrounding them. Recourse to a dictionary produced the Latin equivalent, corona, and so the name coronavirus was born.
9126:
6740:"Simulation of the Clinical and Pathological Manifestations of Coronavirus Disease 2019 (COVID-19) in a Golden Syrian Hamster Model: Implications for Disease Pathogenesis and Transmissibility"
659:, Bethesda, were the first to study the structure of MHV in 1965. They also observed the surface projections as on IBV, stating, "The outer surface of the particle is covered by 'spicules'."
5883:
van Doremalen, Neeltje; Bushmaker, Trenton; Morris, Dylan H.; Holbrook, Myndi G.; Gamble, Amandine; Williamson, Brandi N.; Tamin, Azaibi; Harcourt, Jennifer L.; Thornburg, Natalie J. (2020).
5331:
Ksiazek, Thomas G.; Erdman, Dean; Goldsmith, Cynthia S.; Zaki, Sherif R.; Peret, Teresa; Emery, Shannon; Tong, Suxiang; Urbani, Carlo; Comer, James A.; Lim, Wilina; Rollin, Pierre E. (2003).
5809:
1072:, which is especially fostered by the evidence that different mammals can be infected. Several animals have been investigated and are proven to be negative. Among the possible carriers are
1068:). These data indicate that the virus most probably originated in bats. Given the differences between human and bat viruses, it is speculated that bat viruses were acquired through carrier
8905:
van Boheemen, Sander; de Graaf, Miranda; Lauber, Chris; Bestebroer, Theo M.; Raj, V. Stalin; Zaki, Ali Moh; Osterhaus, Albert D. M. E.; Haagmans, Bart L.; Gorbalenya, Alexander E. (2012).
5280:
Poutanen, Susan M.; Low, Donald E.; Henry, Bonnie; Finkelstein, Sandy; Rose, David; Green, Karen; Tellier, Raymond; Draker, Ryan; Adachi, Dena; Ayers, Melissa; Chan, Adrienne K. (2003).
7267:"Studies on transmissible gastroenteritis of swine I. The isolation and identification of a cytopathogenic virus of transmissible gastroenteritis in primary swine kidney cell cultures"
5571:
Lau, Susanna K. P.; Woo, Patrick C. Y.; Li, Kenneth S. M.; Huang, Yi; Tsoi, Hoi-Wah; Wong, Beatrice H. L.; Wong, Samson S. Y.; Leung, Suet-Yi; Chan, Kwok-Hung; Yuen, Kwok-Yung (2005).
9111:
982:(CDC) in US in May. In October, the samples from Guangdong were established as the prototype specimens, and the name SARS coronavirus (SARS CoV) was introduced. ICTV approved it as
8218:
Reagan, Reginald L.; Porter, J. R.; Guemlek, Mary; Brueckner, A. L. (1956). "Response of the cave bat (Myotis lucifugus) to the Wachtel IBV strain of infectious bronchitis virus".
9116:
6738:
Chan, Jasper Fuk-Woo; Zhang, Anna Jinxia; Yuan, Shuofeng; Poon, Vincent Kwok-Man; Chan, Chris Chung-Sing; Lee, Andrew Chak-Yiu; Chan, Wan-Mui; Fan, Zhimeng; Tsoi, Hoi-Wah (2020).
599:
7012:
Adams, Michael J.; Lefkowitz, Elliot J.; King, Andrew M. Q.; Harrach, Balázs; Harrison, Robert L.; Knowles, Nick J.; Kropinski, Andrew M.; Krupovic, Mart; Kuhn, Jens H. (2016).
750:
Proposal of the new name was submitted to and accepted by the International Committee for the Nomenclature of Viruses (ICNV, established in 1966). The 16 November 1968 issue of
6624:
Lam, Tommy Tsan-Yuk; Jia, Na; Zhang, Ya-Wei; Shum, Marcus Ho-Hin; Jiang, Jia-Fu; Zhu, Hua-Chen; Tong, Yi-Gang; Shi, Yong-Xia; Ni, Xue-Bing; Liao, Yun-Shi; Li, Wen-Juan (2020).
6077:
Lam, Tommy Tsan-Yuk; Jia, Na; Zhang, Ya-Wei; Shum, Marcus Ho-Hin; Jiang, Jia-Fu; Zhu, Hua-Chen; Tong, Yi-Gang; Shi, Yong-Xia; Ni, Xue-Bing; Liao, Yun-Shi; Li, Wen-Juan (2020).
7847:"Characterization of monoclonal antibodies against feline infectious peritonitis virus type II and antigenic relationship between feline, porcine, and canine coronaviruses"
560:) further indicated that the virus was not related (not reactive) to antibodies (serotypes) of any known viruses at the time. Reporting in the 5 June 1965 issue of the
9058:"Evidence of the recombinant origin of a bat severe acute respiratory syndrome (SARS)-like coronavirus and its implications on the direct ancestor of SARS coronavirus"
5511:
Li, Wendong; Shi, Zhengli; Yu, Meng; Ren, Wuze; Smith, Craig; Epstein, Jonathan H.; Wang, Hanzhong; Crameri, Gary; Hu, Zhihong; Zhang, Huajun; Zhang, Jianhong (2005).
4510:
1168:
PTGV, FIPV, and dog virus were shown to have apparent relatedness by the early 1990s. In 1998, a study revealed that FCoV originates from genetic recombination with
556:
to induce cold in antibiotic-treated volunteers (indicating it was not a bacterium), and grown in human-embryo-trachea epithelial cell culture. Serological tests (
2592:
Tyrrell DA, Bynoe ML, Hitchcock G, Pereira HG, Andrewes CH (January 1960). "Some virus isolations from common colds. I. Experiments employing human volunteers".
722:
All "IBV-like" viruses, 229E, and IBV itself show the following characteristics: (1) an over-all diameter of 160 mμ with a variation of ± 440 mμ; (2) a moderate
9005:
MacLean, Oscar A.; Lytras, Spyros; Weaver, Steven; Singer, Joshua B.; Boni, Maciej F.; Lemey, Philippe; Kosakovsky Pond, Sergei L.; Robertson, David L. (2021).
5231:
Peiris, J. S. M.; Lai, S. T.; Poon, L. L. M.; Guan, Y.; Yam, L. Y. C.; Lim, W.; Nicholls, J.; Yee, W. K. S.; Yan, W. W.; Cheung, M. T.; Cheng, V. C. C. (2003).
955:) are clinically the most important human coronaviruses as they are responsible for a series of global epidemics. There are two species of such coronaviruses:
8766:
Kaneshima, Takashi; Hohdatsu, Tsutomu; Hagino, Ryoko; Hosoya, Sakiko; Nojiri, Yui; Murata, Michiko; Takano, Tomomi; Tanabe, Maki; Tsunemitsu, Hiroshi (2007).
6559:
Xiao, Kangpeng; Zhai, Junqiong; Feng, Yaoyu; Zhou, Niu; Zhang, Xu; Zou, Jie-Jian; Li, Na; Guo, Yaqiong; Li, Xiaobing; Shen, Xuejuan; Zhang, Zhipeng (2020).
6020:
Xiao, Kangpeng; Zhai, Junqiong; Feng, Yaoyu; Zhou, Niu; Zhang, Xu; Zou, Jie-Jian; Li, Na; Guo, Yaqiong; Li, Xiaobing; Shen, Xuejuan; Zhang, Zhipeng (2020).
1099:
517:
Human coronaviruses were discovered as one of the many causative viruses of common cold. Research on the study of common cold originated when the British
5380:
1172:. Based on the molecular and antigenic relationship of the viruses, the viruses of pigs, cats and dogs were merged into a single species and was renamed
7894:
6391:"Serological survey of SARS-CoV-2 for experimental, domestic, companion and wild animals excludes intermediate hosts of 35 different species of animals"
1258:
in the ancestral species that confer an ability to infect animals other than their original hosts. The principal genetic target of recombination is the
7749:"Feline coronavirus type II strains 79-1683 and 79-1146 originate from a double recombination between feline coronavirus type I and canine coronavirus"
6183:
Zhou, Peng; Yang, Xing-Lou; Wang, Xian-Guang; Hu, Ben; Zhang, Lei; Zhang, Wei; Si, Hao-Rui; Zhu, Yan; Li, Bei; Huang, Chao-Lin; Chen, Hui-Dong (2020).
1013:), which were sold at a live-animal market in Guangdong. Further studies in 2005 showed that civets were the intermediate reservoirs of the virus, and
6443:
Boni, Maciej F.; Lemey, Philippe; Jiang, Xiaowei; Lam, Tommy Tsan-Yuk; Perry, Blair W.; Castoe, Todd A.; Rambaut, Andrew; Robertson, David L. (2020).
920:
group of children having respiratory infection in New Haven, Connecticut, US. The origin of the virus remains a mystery, but it is closely related to
8081:
7410:
Zook, B. C.; King, N. W.; Robison, R. L.; McCombs, H. L. (1968). "Ultrastructural evidence for the viral etiology of feline infectious peritonitis".
8858:"Complete Genomic Sequence of Human Coronavirus OC43: Molecular Clock Analysis Suggests a Relatively Recent Zoonotic Coronavirus Transmission Event"
5451:
Guan, Y.; Zheng, B. J.; He, Y. Q.; Liu, X. L.; Zhuang, Z. X.; Cheung, C. L.; Luo, S. W.; Li, P. H.; Zhang, L. J.; Guan, Y. J.; Butt, K. M. (2003).
4631:
Fouchier, Ron A. M.; Hartwig, Nico G.; Bestebroer, Theo M.; Niemeyer, Berend; de Jong, Jan C.; Simon, James H.; Osterhaus, Albert D. M. E. (2004).
701:
sensitive as is avian infectious bronchitis 229 E, have a similar size by filtration and multiply in the presence of an inhibitor of DNA synthesis.
6126:
Zhou, Hong; Chen, Xing; Hu, Tao; Li, Juan; Song, Hao; Liu, Yanran; Wang, Peihan; Liu, Di; Yang, Jing; Holmes, Edward C.; Hughes, Alice C. (2020).
282:. The sample designated B814 was confirmed as novel virus in 1965. New common cold viruses (assigned 229E) collected from medical students at the
971:
754:
reported the justification by J. D. Almeida, D.M. Berry, C.H. Cunningham, D. Hamre, M.S. Hofstad, L. Mallucci, K. McIntosh and D.A.J. Tyrrell as:
1809:
9056:
Hon, Chung-Chau; Lam, Tsan-Yuk; Shi, Zheng-Li; Drummond, Alexei J.; Yip, Chi-Wai; Zeng, Fanya; Lam, Pui-Yi; Leung, Frederick Chi-Ching (2008).
810:
442:
In 1949, Francis Sargent Cheevers, Joan B. Daniels, Alwin M. Pappenheimer and Orville T. Bailey investigated the case of brain disease (murine
5099:
Zhong, N. S.; Zheng, B. J.; Li, Y. M.; Poon, null; Xie, Z. H.; Chan, K. H.; Li, P. H.; Tan, S. Y.; Chang, Q.; Xie, J. P.; Liu, X. Q. (2003).
2787:
Tyrrell DA, Buckland FE, Bynoe ML, Hayflick L (August 1962). "The cultivation in human-embryo cells of a virus (D.C.) causing colds in man".
967:
8511:
Rohaim, Mohammed A.; El Naggar, Rania F.; Abdelsabour, Mohammed A.; Mohamed, Mahmoud H. A.; El-Sabagh, Ibrahim M.; Munir, Muhammad (2020).
737:
resemblance, but Tyrrell thought it inappropriate. Almeida came up with a novel name "coronavirus". Tyrrell wrote of his recollection in
8856:
Vijgen, Leen; Keyaerts, Els; Moës, Elien; Thoelen, Inge; Wollants, Elke; Lemey, Philippe; Vandamme, Anne-Mieke; Van Ranst, Marc (2005).
9121:
979:
587:
In an independent research in US, Dorothy Hamre and John J. Procknow studied respiratory tract infection among medical students at the
375:
518:
6128:"A novel bat coronavirus closely related to SARS-CoV-2 contains natural Insertions at the S1/S2 cleavage site of the spike protein"
5833:
487:
258:
5101:"Epidemiology and cause of severe acute respiratory syndrome (SARS) in Guangdong, People's Republic of China, in February, 2003"
1343:
1283:
split up around 2,400 to 3,300 years ago into bat and avian coronavirus ancestors. Bat coronavirus gave rise to the species of
671:
2627:
Hitchcock G, Tyrrell DA (January 1960). "Some virus isolations from common colds. II. Virus interference in tissue cultures".
625:
were the first to describe the structure of coronavirus using the transmission electron microscopy. In 1948, they reported in
7666:
2662:
Tyrrell DA, Parsons R (January 1960). "Some virus isolations from common colds. III. Cytopathic effects in tissue cultures".
1511:
1423:
208:
6932:
5632:"Outbreak of Novel Coronavirus (SARS-Cov-2): First Evidences From International Scientific Literature and Pending Questions"
7700:"A review of feline infectious peritonitis virus: molecular biology, immunopathogenesis, clinical aspects, and vaccination"
575:
But they contradicted themselves regarding the identity of the virus as they mentioned in the experimental results, saying:
522:
467:
in New York in 1937. However, the Harvard scientists found that the two mice had unusual symptoms other than brain damage (
8907:"Genomic Characterization of a Newly Discovered Coronavirus Associated with Acute Respiratory Distress Syndrome in Humans"
6389:
Deng, Junhua; Jin, Yipeng; Liu, Yuxiu; Sun, Jie; Hao, Liying; Bai, Jingjing; Huang, Tian; Lin, Degui; Jin, Yaping (2020).
1205:, Belgium isolated and identified the new coronavirus in 1978, and designated it CV777. ICTV officially renamed the virus
766:
was accepted as a genus name by ICNV in its first report in 1971. IBV was then officially designated the type species as
486:
In the autumn of 1950 there was a sudden outbreak of fatal hepatitis among laboratory mice (Parkes or P strains) at the
9007:"Natural selection in the evolution of SARS-CoV-2 in bats created a generalist virus and highly capable human pathogen"
6681:
Bao, Linlin; Deng, Wei; Huang, Baoying; Gao, Hong; Liu, Jiangning; Ren, Lili; Wei, Qiang; Yu, Pin; Xu, Yanfeng (2020).
5209:
4692:"Evidence of a novel human coronavirus that is associated with respiratory tract disease in infants and young children"
409:
6841:
Hijawi, B.; Abdallat, M.; Sayaydeh, A.; Alqasrawi, S.; Haddadin, A.; Jaarour, N.; Alsheikh, S.; Alsanouri, T. (2013).
5932:
4790:"Characterization and complete genome sequence of a novel coronavirus, coronavirus HKU1, from patients with pneumonia"
3252:
Reagan, R. L.; Brueckner, A. L. (1952). "Electron microscope studies of four strains of infectious bronchitis virus".
907:
was discovered in January 2003 from a seven-month-old baby in Amsterdam, the Netherlands. The baby was suffering from
8568:
Infection, Genetics and Evolution: Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases
355:
3802:"Classification and nomenclature of viruses. First report of the International Committee on Nomenclature of Viruses"
1224:
were the first to investigate bats as a potential sources of coronavirus in 1956. They experimentally inoculated 44
5836:"The species Severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2"
494:
isolated the causative virus, which experimentally was highly infectious to healthy mice. They named the virus as "
287:
338:), a variant of SARS-CoV, emerged during the past two decades and caused the first pandemics of the 21st century.
6882:
Zaki, Ali M.; van Boheemen, Sander; Bestebroer, Theo M.; Osterhaus, Albert D. M. E.; Fouchier, Ron A. M. (2012).
6843:"Novel coronavirus infections in Jordan, April 2012: epidemiological findings from a retrospective investigation"
4050:"Classification and nomenclature of viruses. Second report of the International Committee on Taxonomy of Viruses"
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Berry, D.M.; Cruickshank, J.G.; Chu, H.P.; Wells, R.J.H. (1964). "The structure of infectious bronchitis virus".
3289:"An electron microscope study of chorioallantoic membrane infected with the virus of avian infectious bronchitis"
1207:
8717:
Wertheim, Joel O.; Chu, Daniel K. W.; Peiris, Joseph S. M.; Kosakovsky Pond, Sergei L.; Poon, Leo L. M. (2013).
8513:"Evolutionary Analysis of Infectious Bronchitis Virus Reveals Marked Genetic Diversity and Recombination Events"
358:
were the first to report what was later identified as coronavirus disease in chickens. Their publication in the
7337:
5933:"COVID-19 Dashboard by the Center for Systems Science and Engineering (CSSE) at Johns Hopkins University (JHU)"
3853:"Isolation of a coronavirus during studies on puffinosis, a disease of the Manx shearwater (Puffinus puffinus)"
3186:
1406:
McIntosh K (1974). "Coronaviruses: A Comparative Review". In Arber W, Haas R, Henle W, Hofschneider PH (eds.).
774:
in 2009). The so-called "hepatoencephalitis group of murine viruses" were grouped into a single species named
498:(MHV)." Gledhill called the experiments on the highly infectious nature of the virus as a "bizarre discovery".
529:(CCRU) at Salisbury in 1946. Directed by Andrewes, the research laboratory discovered several viruses such as
6471:
1127:
502:
5834:
Gorbalenya et al. (Coronaviridae Study Group of the International Committee on Taxonomy of Viruses) (2020).
1103:
in 2016). In 2013, a study revealed that the virus was 100% genetically identical to the coronavirus of the
9136:
7653:. Advances in Experimental Medicine and Biology. Vol. 276. Boston, MA: Springer US. pp. 475–479.
1777:"A filterable virus, distinct from that of laryngotracheitis, the cause of a respiratory disease of chicks"
557:
380:
5453:"Isolation and characterization of viruses related to the SARS coronavirus from animals in southern China"
3288:
1232:) with IBV and found that all of them developed the symptoms of infectious bronchitis. Their report reads:
3510:"The morphology of three previously uncharacterized human respiratory viruses that grow in organ culture"
2253:
Hirano, Norio; Goto, Naoaki; Ogawa, Tetsuo; Ono, Katsuhiko; Murakami, Toshiaki; Fujiwara, Kosaku (1980).
1251:
1196:
was not a fatal disease. The case was first reported by John Godfrey Oldham in a letter to the editor of
692:
534:
491:
235:
133:
1604:
Hudson CB, Beaudette FR (July 1932). "Infection of the Cloaca with the Virus of Infectious Bronchitis".
928:) coronavirus and can survive in bat cell lines, suggesting that it is derived from animals (zoonotic).
7014:"Ratification vote on taxonomic proposals to the International Committee on Taxonomy of Viruses (2016)"
4452:"Ratification vote on taxonomic proposals to the International Committee on Taxonomy of Viruses (2009)"
1831:
Boursnell, M. E. G.; Brown, T. D. K.; Foulds, I. J.; Green, P. F.; Tomley, F. M.; Binns, M. M. (1987).
1192:
1061:
6957:"Middle East respiratory syndrome coronavirus (MERS-CoV): announcement of the Coronavirus Study Group"
1334:
975:
656:
544:
506:
414:
391:
indicated a clear distinction of infectious bronchitis from infectious laryngotracheitis (cause by a
295:
201:
6240:
Andersen, Kristian G.; Rambaut, Andrew; Lipkin, W. Ian; Holmes, Edward C.; Garry, Robert F. (2020).
3363:"An electron microscope study of the development of a mouse hepatitis virus in tissue culture cells"
1408:
Current Topics in Microbiology and Immunology / Ergebnisse der Mikrobiologie und Immunitätsforschung
597:). They presented their discovery as "A new virus isolated from the human respiratory tract" in the
7618:
Binn, L. N.; Lazar, E. C.; Keenan, K. P.; Huxsoll, D. L.; Marchwicki, R. H.; Strano, A. J. (1974).
7571:"Feline infectious peritonitis viruses arise by mutation from endemic feline enteric coronaviruses"
6445:"Evolutionary origins of the SARS-CoV-2 sarbecovirus lineage responsible for the COVID-19 pandemic"
5942:
1201:
epidemic diarrhoea." It eventually spread throughout Europe. M. B. Pensaert and P. de Bouck at the
1037:
679:
374:
The causative pathogen could not be identified. Charles D. Hudson and Fred Robert Beaudette at the
62:
3230:
1972:"A Murine Virus (JHM) Causing Disseminated Encephalomyelitis with Extensive Destruction of Myelin"
1874:"A murine virus (JHM) causing disseminated encephalomyelitis with extensive destruction of myelin"
1350:
1161:
In 1974, a new coronavirus was discovered from US military dogs, and was named by ICTV in 1991 as
30:
8144:
7311:
5630:
Amodio, Emanuele; Vitale, Francesco; Cimino, Livia; Casuccio, Alessandra; Tramuto, Fabio (2020).
4139:
Greig, A. S.; Mitchell, D.; Corner, A. H.; Bannister, G. L.; Meads, E. B.; Julian, R. J. (1962).
4089:
3925:
3826:
2356:"Characterization of the virus of sialodacryoadenitis of rats: a member of the coronavirus group"
1262:
gene that codes for the spike (S) protein essential for binding to the host's tissue, as well as
830:(HCoV-OC43) in 1995. While HCoV-OC229E is retained as a valid species, HCoV-OC43 was merged with
723:
642:
290:
revealed that they all belong to the same group of viruses. Making a crucial comparison in 1967,
7447:"An enteric coronavirus infection of cats and its relationship to feline infectious peritonitis"
5684:
5372:
4376:
4114:
3900:
3613:"Direct electron-microscopy of organ cultures for the detection and characterization of viruses"
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Kerr JR, Taylor-Robinson D (2007). "David Arthur John Tyrrell CBE: 19 June 1925 - 2 May 2005".
1833:"Completion of the sequence of the genome of the coronavirus avian infectious bronchitis virus"
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464:
447:
250:
8075:
3801:
3554:"Recovery in tracheal organ cultures of novel viruses from patients with respiratory disease"
2748:"Studies on the pathogenicity for tissue cultures of some viruses isolated from common colds"
2255:"Hydrocephalus in Suckling Rats Infected Intracerebrally with Mouse Hepatitis Virus, MHV-A59"
1330:
1255:
1053:
683:
588:
495:
283:
262:
7645:
McArdle, F.; Bennett, M.; Gaskell, R. M.; Tennant, B.; Kelly, D. F.; Gaskell, C. J. (1990).
3664:"Morphogenesis of avian infectious bronchitis virus and a related human virus (strain 229E)"
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Hamre, D.; Procknow, J. J. (1966). "A new virus isolated from the human respiratory tract".
8575:
8267:
6694:
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6515:
6196:
6139:
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6033:
5976:
5584:
5524:
5464:
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3764:
3617:
3565:
2415:
1613:
675:
194:
75:
8:
5038:
4988:
Esper, Frank; Weibel, Carla; Ferguson, David; Landry, Marie L.; Kahn, Jeffrey S. (2006).
4690:
Esper, Frank; Weibel, Carla; Ferguson, David; Landry, Marie L.; Kahn, Jeffrey S. (2005).
1254:(MRCA). It is suggested that divergences of coronaviruses were the results of sequential
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363:
254:
230:
8579:
8562:
Luk, Hayes K. H.; Li, Xin; Fung, Joshua; Lau, Susanna K. P.; Woo, Patrick C. Y. (2019).
8271:
7647:"Canine Coronavirus Infection in Cats; A Possible Role in Feline Infectious Peritonitis"
7646:
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5588:
5528:
5468:
4648:
3768:
3569:
2419:
1617:
859:
Owing to increasing number and diversity of new species discovered, CTV split the genus
666:
Transmission electron microscopic images of coronaviruses 229E (2), B814 (3) and IBV (4)
40:
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7747:
Herrewegh, A. A.; Smeenk, I.; Horzinek, M. C.; Rottier, P. J.; de Groot, R. J. (1998).
7724:
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4534:
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4432:
4353:
4329:"Detection of a group 2 coronavirus in dogs with canine infectious respiratory disease"
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267:
8882:
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7206:
6925:"Novel coronavirus infection - update (Middle East respiratory syndrome- coronavirus)"
5248:
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9087:
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8987:
8956:"Middle East Respiratory Syndrome Coronavirus (MERS-CoV) origin and animal reservoir"
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Morris, J. A. (1959). "A new member of hepato-encephalitis group of murine viruses".
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invented the collective name coronavirus, as all those viruses were characterised by
246:
175:
149:
8873:
8067:
7989:"Porcine epidemic diarrhea virus: An emerging and re-emerging epizootic swine virus"
7796:
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7764:
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5573:"Severe acute respiratory syndrome coronavirus-like virus in Chinese horseshoe bats"
5494:
4633:"A previously undescribed coronavirus associated with respiratory disease in humans"
4617:
4436:
4215:
3648:
3079:
2578:
2307:"Rat coronavirus (RCV): A prevalent, naturally occurring pneumotropic virus of rats"
2211:
Manaker, Robert A.; Piczak, Chester V.; Miller, Alice A.; Stanton, Mearl F. (1961).
2197:
1641:
1460:"The chronicles of coronaviruses: the bronchitis, the hepatitis and the common cold"
1321:
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Vabret, A.; Dina, J.; Gouarin, S.; Petitjean, J.; Corbet, S.; Freymuth, F. (2006).
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3016:
3008:
2964:
2923:
2884:
2843:
2835:
2796:
2759:
2718:
2710:
2671:
2636:
2601:
2558:
2521:
2480:
2472:
2445:
2423:
2375:
2367:
2326:
2318:
2274:
2266:
2224:
2177:
2139:
2102:
2063:
2028:
1991:
1983:
1942:
1934:
1893:
1885:
1844:
1788:
1747:
1739:
1706:
1668:
1621:
1570:
1471:
1411:
1383:
1365:
1225:
1202:
662:
593:
580:
526:
253:
in Boston. The virus causing the disease was called JHM (after Harvard pathologist
115:
57:
47:
7238:
Doyle, L. P.; Hutchings, L. M. (1946). "A transmissible gastroenteritis in pigs".
6924:
4805:
3552:
McIntosh, K.; Dees, J. H.; Becker, W. B.; Kapikian, A. Z.; Chanock, R. M. (1967).
9023:
8587:
7658:
7620:"Recovery and characterization of a coronavirus from military dogs with diarrhea"
5419:
4049:
3153:
1625:
286:
were also reported in 1966. Structural analyses of IBV, MHV, B814 and 229E using
52:
5036:
1415:
7537:
7423:
7380:
7151:
7112:
6859:
6842:
6185:"A pneumonia outbreak associated with a new coronavirus of probable bat origin"
5726:
5577:
Proceedings of the National Academy of Sciences of the United States of America
5168:
4989:
4888:"Evidence of human coronavirus HKU1 and human bocavirus in Australian children"
4637:
Proceedings of the National Academy of Sciences of the United States of America
4198:
4181:
3558:
Proceedings of the National Academy of Sciences of the United States of America
3106:
2872:
2476:
2371:
2181:
1142:
1073:
1045:
1014:
921:
916:
612:
8972:
8636:
8479:
8186:
8005:
7029:
6707:
6682:
6650:
6625:
6585:
6560:
6527:
6504:"Probable pangolin origin of SARS-CoV-2 associated with the COVID-19 outbreak"
6461:
6444:
6257:
6208:
6151:
6103:
6078:
6046:
6021:
5988:
5965:"Probable pangolin origin of SARS-CoV-2 associated with the COVID-19 outbreak"
5851:
5648:
5373:"ICTV Taxonomy history: Severe acute respiratory syndrome-related coronavirus"
4904:
4467:
3526:
3509:
3304:
2888:
1849:
1832:
646:
had "pear-shaped projections", which were names the "spikes" and described as:
229:
and the diseases they cause. It starts with the first report of a new type of
9105:
8038:
Wood, E. (1977). "An apparently new syndrome of porcine epidemic diarrhoea".
6980:
6805:
6594:
6356:
6306:
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5201:
4278:
Guy, J. S.; Breslin, J. J.; Breuhaus, B.; Vivrette, S.; Smith, L. G. (2000).
3461:"The structure of antigen-antibody complexes. A study by electron microscopy"
3265:
1476:
1459:
1379:
908:
468:
392:
226:
170:
141:
8280:
8255:
7446:
6884:"Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia"
5597:
5537:
5477:
5452:
5202:"Severe Acute Respiratory Syndrome (SARS) - multi-country outbreak - Update"
4886:
Sloots, T; McErlean, P; Speicher, D; Arden, K; Nissen, M; MacKay, I (2006).
4657:
3012:
2032:
1521:
1370:
9091:
9042:
8991:
8940:
8891:
8842:
8793:
8768:"The infectivity and pathogenicity of a group 2 bovine coronavirus in pups"
8752:
8703:
8654:
8605:
8548:
8497:
8448:
8399:
8348:
8289:
8204:
8024:
7973:
7940:"Porcine epidemic diarrhea: A retrospect from Europe and matters of debate"
7619:
7586:
7555:
7503:
7353:
7292:
7251:
7224:
7175:
7136:
7097:
7079:
7047:
6998:
6909:
6868:
6824:
6789:"Analysis of Possible Intermediate Hosts of the New Coronavirus SARS-CoV-2"
6773:
6716:
6659:
6602:
6545:
6480:
6424:
6375:
6324:
6275:
6226:
6169:
6112:
6063:
6006:
5918:
5869:
5795:
5744:
5667:
5616:
5546:
5486:
5437:
5358:
5317:
5266:
5186:
5134:
5085:
5054:
5023:
5005:
4974:
4923:
4872:
4823:
4774:
4725:
4676:
4609:
4568:
4485:
4428:
4401:
Woo, Patrick C. Y.; Lau, Susanna K. P.; Huang, Yi; Yuen, Kwok-Yung (2009).
4362:
4313:
4166:
4016:
3728:
3494:
3445:
3396:
3347:
3312:
3273:
3238:
3202:
3071:
3030:
2937:
2896:
2857:
2808:
2773:
2732:
2714:
2683:
2648:
2613:
2570:
2562:
2535:
2437:
2236:
2228:
2189:
2151:
2116:
2075:
2040:
2005:
1956:
1907:
1761:
1633:
1006:
958:
538:
452:
443:
371:
from infected to healthy chickens. The maximum mortality recorded was 90%.
299:
291:
8922:
8529:
8051:
7880:
7831:
7782:
7733:
7676:
7631:
7624:
Proceedings, Annual Meeting of the United States Animal Health Association
7604:
7462:
7388:
6900:
6883:
6755:
4327:
Erles, Kerstin; Toomey, Crista; Brooks, Harriet W.; Brownlie, Joe (2003).
4207:
4034:
3985:
3886:
3697:
3640:
3597:
3578:
3535:
3476:
3171:
3114:
2978:
2839:
2494:
2389:
2340:
2288:
2130:
Gledhill AW (1953). "Virus hepatitis of mice. II. The complex aetiology".
1858:
1728:"A Filtrable Virus, the Cause of Infectious Laryngotracheitis of Chickens"
1590:
1387:
1083:
705:
346:
9073:
8734:
8685:
8462:
Forni, Diego; Cagliani, Rachele; Clerici, Mario; Sironi, Manuela (2017).
8059:
7167:
7128:
6972:
6290:
5900:
5885:"Aerosol and Surface Stability of SARS-CoV-2 as Compared with SARS-CoV-1"
5349:
5332:
5298:
5281:
5039:"Update: Outbreak of severe acute respiratory syndrome - worldwide, 2003"
4854:
4756:
4182:"Pathology of neonatal calf diarrhea induced by a coronavirus-like agent"
4075:
3427:
2019:
Pappenheimer AM (May 1958). "Pathology of infection with the JHM virus".
1987:
1938:
1889:
1743:
1501:
641:, Middlesex, UK, with J.G. Cruickshank, H.P. Chu and R.J.H. Wells at the
634:
in 1957 when they observed IBVs as "ring or doughnut-shaped structures."
460:
279:
82:
22:
8784:
8767:
8430:
8130:
7445:
Pedersen, N. C.; Boyle, J. F.; Floyd, K.; Fudge, A.; Barker, J. (1981).
5810:"Naming the coronavirus disease (COVID-19) and the virus that causes it"
4741:"Evidence supporting a zoonotic origin of human coronavirus strain NL63"
4264:
4231:"Coronavirus propagated from patient with non-bacterial gastroenteritis"
3378:
2912:"On the growth of certain "newer" respiratory viruses in organ cultures"
1337:). The updated content was reintegrated into the Knowledge page under a
8239:
8112:
7862:
6406:
5333:"A novel coronavirus associated with severe acute respiratory syndrome"
4419:
4402:
3967:
3868:
3631:
3612:
3187:"Electron micrograph of the virus of infectious bronchitis of chickens"
2322:
2212:
1793:
1776:
1711:
1694:
1673:
1656:
1582:
1250:
It is not known with certainty when all coronaviruses evolved from the
1093:
335:
8380:
8329:
7367:
Wolfe, L.G.; Griesemer, R.A. (1966). "Feline infectious peritonitis".
5776:
5308:
5233:"Coronavirus as a possible cause of severe acute respiratory syndrome"
4503:"ICTV 9th Report (2011): Coronaviridae (Virus Taxonomy: 2020 Release)"
4066:
3185:
Reagan, R. L.; Hauser, J. E.; Lillie, M. G.; Craig Jr., A. H. (1948).
2824:"Virus isolations from common colds occurring in a residential school"
2143:
2067:
583:
used, but might be distantly related to influenza C or Sendai viruses.
8564:"Molecular epidemiology, evolution and phylogeny of SARS coronavirus"
8171:"Current status of porcine epidemic diarrhoea (PED) in European pigs"
4531:
3776:
2428:
2403:
939:
904:
879:. As of 2022, there are 52 species of coronaviruses in the subfamily
579:
It was concluded that B814 did not belong to any of the serotypes of
476:
8904:
8231:
7795:
7064:"Middle East respiratory syndrome coronavirus in bats, Saudi Arabia"
6561:"Isolation of SARS-CoV-2-related coronavirus from Malayan pangolins"
6022:"Isolation of SARS-CoV-2-related coronavirus from Malayan pangolins"
5882:
5512:
4001:"Cultivation of 'difficult' viruses from patients with common colds"
2997:"Cultivation of a Novel Type of Common-cold Virus in Organ Cultures"
1574:
943:
the virus was subsequently reported from Australia, Europe, and US.
731:
424:
strain. These results show the identity of the two strains of virus.
8809:"Isolation and sequence analysis of canine respiratory coronavirus"
8097:"A new coronavirus-like particle associated with diarrhea in swine"
6881:
6626:"Identifying SARS-CoV-2-related coronaviruses in Malayan pangolins"
6079:"Identifying SARS-CoV-2-related coronaviruses in Malayan pangolins"
4955:
4707:
4550:
4180:
Mebus, C. A.; Stair, E. L.; Rhodes, M. B.; Twiehaus, M. J. (1973).
4141:"A hemagglutinating virus producing encephalomyelitis in baby pigs"
1410:. Berlin, Heidelberg: Springer Berlin Heidelberg. pp. 85–129.
1024:
952:
472:
368:
327:
319:
311:
303:
97:
4939:"Detection of the New Human Coronavirus HKU1: A Report of 6 Cases"
4280:"Characterization of a coronavirus isolated from a diarrheic foal"
1970:
Bailey OT, Pappenheimer AM, Cheever FS, Daniels JB (August 1949).
1561:
Fabricant J (1998). "The early history of infectious bronchitis".
678:
as an electron microscopist. While working as a technician at the
670:
In 1966, Tyrrell sought the help of Anthony Peter Waterson at the
8510:
5074:
Zhonghua Liu Xing Bing Xue Za Zhi = Zhonghua Liuxingbingxue Zazhi
4630:
3662:
Becker, W. B.; McIntosh, K.; Dees, J. H.; Chanock, R. M. (1967).
3138:"Growth and intracellular development of a new respiratory virus"
257:). Three years later a new mouse hepatitis was reported from the
8716:
7478:"Coronavirus-like Particles in the Feces of a Cat with Diarrhea"
4839:"Coronavirus HKU1 and other coronavirus infections in Hong Kong"
1969:
600:
Proceedings of the Society for Experimental Biology and Medicine
8954:
Mohd, Hamzah A.; Al-Tawfiq, Jaffar A.; Memish, Ziad A. (2016).
7271:
Canadian Journal of Comparative Medicine and Veterinary Science
6840:
5937:
5282:"Identification of severe acute respiratory syndrome in Canada"
4145:
Canadian Journal of Comparative Medicine and Veterinary Science
1291:
that infect mammals, while avian coronavirus produced those of
912:
809:
was adopted as the family name in the ICNV (soon after renamed
9127:
Knowledge articles published in peer-reviewed literature (W2J)
7746:
7526:
The Veterinary Clinics of North America. Small Animal Practice
7188:
7152:"Evidence for camel-to-human transmission of MERS coronavirus"
7113:"Evidence for camel-to-human transmission of MERS coronavirus"
8765:
5402:
Vijayanand, Pandurangan; Wilkins, Ed; Woodhead, Mark (2004).
1060:), and 96% identity with Bat SARS-like coronavirus RaTG13 of
408:
In 1936, Jerry Raymond Beach and Oscar William Schalm at the
275:
8217:
7895:"ICTV Taxonomy history: Feline infectious peritonitis virus"
7644:
7569:
Vennema, H.; Poland, A.; Foley, J.; Pedersen, N. C. (1998).
5758:
Gralinski, Lisa E.; Menachery, Vineet D. (24 January 2020).
4138:
2786:
2745:
2591:
2213:"A Hepatitis Virus Complicating Studies With Mouse Leukemia"
2054:
Dick GW (1953). "Virus hepatitis of mice. I. Introductory".
1923:"Spontaneous Encephalomyelitis of Mice, A New Virus Disease"
8362:
Wong, Antonio; Li, Xin; Lau, Susanna; Woo, Patrick (2019).
7111:
Madani, Tariq A.; Azhar, Esam I.; Hashem, Anwar M. (2014).
6239:
5279:
4885:
4403:"Coronavirus diversity, phylogeny and interspecies jumping"
3459:
Almeida, J.; Cinader, B.; Howatson, A. (1 September 1963).
3184:
2132:
Schweizerische Zeitschrift für Pathologie und Bakteriologie
2056:
Schweizerische Zeitschrift für Pathologie und Bakteriologie
367:
between chickens or experimental transfer of the bronchial
92:
87:
8461:
7568:
7150:
Drosten, Christian; Kellam, Paul; Memish, Ziad A. (2014).
6683:"The pathogenicity of SARS-CoV-2 in hACE2 transgenic mice"
5629:
5330:
4936:
4277:
3551:
2210:
1237:
intramuscular group, whereas the controls appeared normal.
966:
Two distinct viruses are known under this species, namely
9004:
8855:
8412:
7011:
5401:
5037:
Centers for Disease Control and Prevention (CDC) (2003).
4987:
4689:
4326:
3661:
1830:
562:
225:
is an account of the discovery of the diseases caused by
9112:
Knowledge articles published in peer-reviewed literature
8256:"The genome sequence of the SARS-associated coronavirus"
8145:"ICTV Taxonomy history: Porcine epidemic diarrhea virus"
5513:"Bats are natural reservoirs of SARS-like coronaviruses"
4179:
3325:
3215:
9117:
Knowledge articles published in WikiJournal of Medicine
7444:
7060:
6953:
5711:"2019 Novel coronavirus: where we are and what we know"
3136:
Hamre, Dorothy; Kindig, David A.; Mann, Judith (1967).
332:
Severe acute respiratory syndrome-related coronavirus 2
8311:
Fan, Yi; Zhao, Kai; Shi, Zheng-Li; Zhou, Peng (2019).
7617:
7409:
7240:
Journal of the American Veterinary Medical Association
6338:
Abdel-Moneim, Ahmed S.; Abdelwhab, Elsayed M. (2020).
4584:"History and recent advances in coronavirus discovery"
3458:
3412:"A negative staining method for cell-associated virus"
3046:"History and recent advances in coronavirus discovery"
2746:
Taylor-Robinson D, Hucker R, Tyrrell DA (April 1962).
1814:
Journal of the American Veterinary Medical Association
1541:
Journal of the American Veterinary Medical Association
1537:"An apparently new respiratory disease of baby chicks"
709:
Electron microscopic image of human coronavirus OC43 (
446:) at the Department of Bacteriology and Immunology of
360:
Journal of the American Veterinary Medical Association
8807:
Erles, Kerstin; Shiu, Kai-Biu; Brownlie, Joe (2007).
8149:
International Committee on Taxonomy of Viruses (ICTV)
7899:
International Committee on Taxonomy of Viruses (ICTV)
7316:
International Committee on Taxonomy of Viruses (ICTV)
6337:
5377:
International Committee on Taxonomy of Viruses (ICTV)
4381:
International Committee on Taxonomy of Viruses (ICTV)
4119:
International Committee on Taxonomy of Viruses (ICTV)
4094:
International Committee on Taxonomy of Viruses (ICTV)
3930:
International Committee on Taxonomy of Viruses (ICTV)
3905:
International Committee on Taxonomy of Viruses (ICTV)
3831:
International Committee on Taxonomy of Viruses (ICTV)
3360:
1349:
Kholhring Lalchhandama; et al. (5 August 2022).
1030:
Severe acute respiratory syndrome-related coronavirus
988:
Severe acute respiratory syndrome-related coronavirus
961:
Severe acute respiratory syndrome-related coronavirus
931:
896:
820:
in the ICNV first report. The species was split into
479:. The new virus was named JHM, after the initials of
316:
Severe acute respiratory syndrome-related coronavirus
8252:
5404:"Severe acute respiratory syndrome (SARS): a review"
5153:"The chronology of the 2002-2003 SARS mini pandemic"
2551:
Biographical Memoirs of Fellows of the Royal Society
1100:
Middle East respiratory syndrome-related coronavirus
1086:
Middle East respiratory syndrome-related coronavirus
324:
Middle East respiratory syndrome-related coronavirus
8953:
7844:
7476:Dea, S.; Roy, R. S.; Elazhary, M. A. S. Y. (1982).
7149:
6340:"Evidence for SARS-CoV-2 Infection of Animal Hosts"
3287:Domermuth, C. H.; Edwards, O. F. (1 January 1957).
2821:
2548:
2507:
1810:"Cultivation of the virus of infectious bronchitis"
1506:. Oxford: Oxford University Press. pp. 94–96.
512:
437:
341:
274:In 1961, a virus was obtained from a school boy in
8621:"Origin and evolution of pathogenic coronaviruses"
8464:"Molecular Evolution of Human Coronavirus Genomes"
8220:Transactions of the American Microscopical Society
5757:
2252:
1184:
9055:
8806:
8168:
7649:. In Cavanagh, David; Brown, T. David K. (eds.).
7110:
6737:
6472:20.500.11820/222bb9b9-2481-4086-bd22-f0b200930bef
6442:
5230:
4990:"Coronavirus HKU1 Infection in the United States"
4738:
3998:
2699:"Some further virus isolations from common colds"
2354:Bhatt, P. N.; Percy, D. H.; Jonas, A. M. (1972).
2305:Parker, J. C.; Cross, S. S.; Rowe, W. P. (1970).
1134:in the ICNV first report in 1971, and changed to
951:Coronaviruses that are transmitted from animals (
778:as approved in 1971. The species was merged with
732:Invention of the name and history of the taxonomy
354:Arthur Frederick Schalk and Merle C. Fawn at the
261:in London. The causative virus was identified as
9103:
8719:"A case for the ancient origin of coronaviruses"
8094:
7937:
6558:
6019:
5098:
3999:Tyrrell, D. A.; Bynoe, M. L.; Hoorn, B. (1968).
3286:
2626:
2088:
832:Porcine hemagglutinating encephalomyelitis virus
655:J. F. David-Ferreira and R. A. Manaker from the
630:Charles Henry Domermuth and O.F. Edwards at the
350:Electron microscopic image of Avian coronavirus.
6680:
6623:
6076:
4400:
4115:"ICTV Taxonomy history: Human coronavirus 229E"
3952:"Antigenic relationships amongst coronaviruses"
3926:"ICTV Taxonomy history: Human coronavirus 229E"
3409:
3251:
3135:
2353:
2304:
1807:
1692:
1603:
790:in 2009. 229E and OC43 were collectively named
8310:
7938:Pensaert, Maurice B.; Martelli, Paolo (2016).
7475:
7366:
7237:
6787:Yuan, Shu; Jiang, Si-Cong; Li, Zi-Lin (2020).
6502:Zhang, Tao; Wu, Qunfu; Zhang, Zhigang (2020).
6182:
5963:Zhang, Tao; Wu, Qunfu; Zhang, Zhigang (2020).
5450:
3610:
3507:
3361:David-Ferreira, J. F.; Manaker, R. A. (1965).
2822:Kendall EJ, Bynoe ML, Tyrrell DA (July 1962).
2661:
2510:"Some new or little-known respiratory viruses"
1871:
1499:
811:International Committee on Taxonomy of Viruses
490:, Mill Hill, London. Alan Watson Gledhill and
8169:Antas, Marta; Woźniakowski, Grzegorz (2019).
8080:: CS1 maint: DOI inactive as of March 2024 (
6388:
5570:
5070:
4787:
3850:
3092:
2300:
2298:
1132:Transmissible gastro-enteritis virus of swine
1114:
984:Severe acute respiratory syndrome coronavirus
607:
202:
8667:
8561:
8361:
7845:Hohdatsu, T.; Okada, S.; Koyama, H. (1991).
6501:
6288:
6125:
5962:
4836:
4582:Kahn, Jeffrey S.; McIntosh, Kenneth (2005).
4581:
3611:Tyrrell, D. A. J.; Almeida, June D. (1967).
3044:Kahn, Jeffrey S.; McIntosh, Kenneth (2005).
3043:
2994:
2909:
2696:
2465:Proceedings of the Royal Society of Medicine
2018:
1503:Cold Wars: The Fight Against the Common cold
1500:Tyrrell, D. A. J.; Fielder, Michael (2002).
1457:
891:
739:Cold Wars: The Fight Against the Common Cold
7312:"ICTV Taxonomy history: Alphacoronavirus 1"
6786:
5925:
4535:"Identification of a new human coronavirus"
3901:"ICTV Taxonomy history: Murine coronavirus"
1774:
1136:Porcine transmissible gastroenteritis virus
850:(discovered in 2003) into a single species
8619:Cui, Jie; Li, Fang; Shi, Zheng-Li (2019).
8415:"Global patterns in coronavirus diversity"
8364:"Global epidemiology of bat coronaviruses"
7919:Oldham, J (1972). "Letter to the editor".
5510:
4377:"ICTV Taxonomy history: Betacoronavirus 1"
4228:
3827:"ICTV Taxonomy history: Avian coronavirus"
3508:Almeida, J. D.; Tyrrell, D. A. J. (1967).
2873:"Respiratory viruses in model experiments"
2295:
2089:Gledhill AW, Andrewes CH (December 1951).
1534:
1347:). The version of record as reviewed is:
980:Centers for Disease Control and Prevention
376:New Jersey Agricultural Experiment Station
209:
195:
9081:
9032:
9022:
8981:
8971:
8930:
8881:
8832:
8783:
8772:The Journal of Veterinary Medical Science
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8528:
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8004:
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7821:
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7723:
7594:
7545:
7493:
7335:
7282:
7264:
7214:
7087:
7037:
6988:
6899:
6858:
6814:
6804:
6763:
6706:
6649:
6584:
6535:
6470:
6460:
6414:
6365:
6355:
6314:
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6216:
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6045:
5996:
5908:
5859:
5785:
5775:
5734:
5708:
5657:
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5606:
5596:
5536:
5476:
5427:
5348:
5307:
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5256:
5176:
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5013:
4964:
4954:
4913:
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4862:
4813:
4764:
4715:
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4599:
4558:
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4254:
4197:
4156:
4065:
4024:
3975:
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3876:
3784:
3736:
3687:
3630:
3587:
3577:
3525:
3484:
3435:
3386:
3161:
3061:
3020:
2968:
2927:
2916:British Journal of Experimental Pathology
2847:
2763:
2752:British Journal of Experimental Pathology
2722:
2525:
2514:Bulletin of the World Health Organization
2484:
2427:
2379:
2330:
2278:
2106:
2095:British Journal of Experimental Pathology
1995:
1946:
1897:
1872:Cheever FS, Daniels JB (September 1949).
1848:
1792:
1751:
1710:
1672:
1654:
1560:
1475:
1369:
946:
566:, Tyrrell and Malcolm L. Bynoe concluded:
8618:
7519:
5685:"Timeline of WHO's response to COVID-19"
4588:The Pediatric Infectious Disease Journal
4449:
3410:Almeida, J. D.; Howatson, A. F. (1963).
3050:The Pediatric Infectious Disease Journal
2957:The Yale Journal of Biology and Medicine
2458:
2217:Journal of the National Cancer Institute
2129:
2021:Journal of the National Cancer Institute
1405:
1044:. The source of the virus is not known.
704:
661:
611:
345:
7515:
7513:
7451:American Journal of Veterinary Research
6836:
6834:
6438:
6436:
6434:
6289:Leitner, Thomas; Kumar, Sudhir (2020).
5709:Cheng, Zhangkai J.; Shan, Jing (2020).
5679:
5677:
3254:American Journal of Veterinary Research
2461:"Twenty years' work on the common cold"
1920:
1245:
488:National Institute for Medical Research
483:, a pioneer microbiologist at Harvard.
362:in 1931 indicates that there was a new
259:National Institute for Medical Research
238:(IBV), but later officially renamed as
9104:
8095:Pensaert, M. B.; de Bouck, P. (1978).
7918:
7306:
7304:
7302:
5760:"Return of the Coronavirus: 2019-nCoV"
5566:
5564:
5506:
5504:
5150:
4497:
4495:
4090:"ICTV Taxonomy history: Coronaviridae"
4047:
3851:Nuttall, P. A.; Harrap, K. A. (1982).
2697:Tyrrell DA, Bynoe ML (February 1961).
2248:
2246:
2167:
2163:
2161:
1808:Beaudette, F.R.; Hudson, B.D. (1937).
7697:
5383:from the original on 22 February 2020
5146:
5144:
5066:
5064:
5043:Morbidity and Mortality Weekly Report
3956:Archiv für die gesamte Virusforschung
3799:
3710:
3547:
3545:
2990:
2988:
2950:
2870:
2311:Archiv für die gesamte Virusforschung
1725:
1495:
1493:
1491:
1489:
1487:
1138:(PTGV) in the second report in 1976.
1119:
1109:Taphozous perforatus coronavirus HKU4
8037:
7510:
6847:Eastern Mediterranean Health Journal
6831:
6431:
5674:
3465:The Journal of Experimental Medicine
2995:Tyrrell, DA; Bynoe, ML (June 1965).
2053:
1976:The Journal of Experimental Medicine
1927:The Journal of Experimental Medicine
1878:The Journal of Experimental Medicine
1732:The Journal of Experimental Medicine
1688:
1686:
1684:
1556:
1554:
1453:
1451:
1449:
1447:
1445:
1443:
1441:
1439:
1437:
1435:
1401:
1399:
1215:
245:A new brain disease of mice (murine
7986:
7299:
7156:The New England Journal of Medicine
7117:The New England Journal of Medicine
6922:
6888:The New England Journal of Medicine
6395:Transboundary and Emerging Diseases
6242:"The proximal origin of SARS-CoV-2"
5889:The New England Journal of Medicine
5561:
5501:
5337:The New England Journal of Medicine
5286:The New England Journal of Medicine
5199:
4930:
4492:
4229:Caul, E. O.; Clarke, S. K. (1975).
2508:Andrewes CH, Worthington G (1959).
2243:
2158:
1820:(1): 51–60 – via archive.org.
1150:(FIPV) to include both the viruses.
1148:Feline infectious peritonitis virus
672:St Thomas's Hospital Medical School
13:
7338:"Some important disorders of cats"
7191:"Middle East respiratory syndrome"
5212:from the original on 30 March 2003
5141:
5061:
4696:The Journal of Infectious Diseases
4601:10.1097/01.inf.0000188166.17324.60
3542:
3063:10.1097/01.inf.0000188166.17324.60
2985:
2910:Hoorn, B.; Tyrrell, D. A. (1965).
2360:The Journal of Infectious Diseases
2271:10.1111/j.1348-0421.1980.tb02887.x
1484:
1126:A viral infection in pigs, called
816:229E and OC43 were together named
651:bulbous mass 90-110 Å in diameter.
410:University of California, Berkeley
278:, England, who was suffering from
14:
9148:
9122:Externally peer reviewed articles
6291:"Where did SARS-CoV-2 come from?"
4407:Experimental Biology and Medicine
3095:Experimental Biology and Medicine
2170:Experimental Biology and Medicine
1681:
1551:
1432:
1396:
1220:Reagan and his colleagues at the
1021:species) were the natural hosts.
768:Avian infectious bronchitis virus
616:Structural model of a coronavirus
356:North Dakota Agricultural College
9049:
8998:
8947:
8898:
8849:
8800:
8759:
8710:
8661:
8612:
8555:
8504:
8455:
8406:
8355:
8304:
8246:
8211:
8162:
8137:
8088:
8031:
7980:
7931:
7912:
7887:
7838:
7789:
7740:
7691:
7651:Coronaviruses and their Diseases
7638:
7611:
7562:
7469:
7438:
7403:
7360:
7329:
7258:
7231:
7182:
7143:
7104:
7054:
7005:
6947:
6935:from the original on 8 June 2013
6916:
6875:
6780:
6731:
6674:
6617:
6552:
6495:
6382:
6331:
6282:
6233:
6176:
6119:
6070:
6013:
5956:
5876:
5827:
5802:
5751:
5702:
4843:Journal of Clinical Microbiology
4296:10.1128/JCM.38.12.4523-4526.2000
4284:Journal of Clinical Microbiology
2953:"Medical reviews. Coronaviruses"
1693:Bushnell LD, Brandly CA (1933).
1320:
1097:15 May 2013 (but modified it to
1036:million people and resulting in
513:Discovery of human coronaviruses
438:Discovery of mouse coronaviruses
342:Discovery of chicken coronavirus
288:transmission electron microscopy
29:
8874:10.1128/JVI.79.3.1595-1604.2005
7765:10.1128/JVI.72.5.4508-4514.1998
7522:"Feline infectious peritonitis"
7482:The Canadian Veterinary Journal
6793:Frontiers in Veterinary Science
6295:Molecular Biology and Evolution
5623:
5444:
5395:
5365:
5324:
5273:
5224:
5193:
5092:
5030:
4981:
4879:
4830:
4781:
4732:
4683:
4624:
4575:
4525:
4443:
4394:
4369:
4320:
4271:
4222:
4173:
4132:
4107:
4082:
4041:
3992:
3943:
3918:
3893:
3844:
3819:
3793:
3745:
3704:
3655:
3604:
3501:
3452:
3403:
3354:
3319:
3280:
3245:
3209:
3178:
3129:
3086:
3037:
2944:
2903:
2864:
2815:
2780:
2739:
2690:
2655:
2620:
2585:
2542:
2501:
2452:
2404:"RESEARCH into the common cold"
2396:
2347:
2204:
2123:
2082:
2047:
2012:
1963:
1914:
1865:
1824:
1801:
1768:
1208:Porcine epidemic diarrhea virus
1186:Porcine epidemic diarrhea virus
813:, ICTV) second report in 1975.
501:In 1959, John A. Morris at the
231:upper-respiratory tract disease
8825:10.1016/j.virusres.2006.10.004
8175:Journal of Veterinary Research
7956:10.1016/j.virusres.2016.05.030
7698:Olsen, Christopher W. (1993).
5157:Paediatric Respiratory Reviews
3680:10.1128/JVI.1.5.1019-1027.1967
3293:Journal of Infectious Diseases
1719:
1657:"Infectious laryngotracheitis"
1648:
1597:
1528:
1325:This article was submitted to
1306:Canine respiratory coronavirus
1226:cave bats or little brown bats
848:Canine respiratory coronavirus
1:
7207:10.1016/S0140-6736(19)33221-0
5249:10.1016/s0140-6736(03)13077-2
5117:10.1016/s0140-6736(03)14630-2
4806:10.1128/JVI.79.2.884-895.2005
4345:10.1016/s0042-6822(03)00160-0
4247:10.1016/s0140-6736(75)90363-3
2801:10.1016/S0140-6736(62)90107-1
2676:10.1016/S0140-6736(60)90168-9
2641:10.1016/S0140-6736(60)90167-7
2606:10.1016/S0140-6736(60)90166-5
1695:"Laryngotracheitis in chicks"
1315:
1158:(FCoV) was then widely used.
1128:transmissible gastroenteritis
503:National Institutes of Health
9024:10.1371/journal.pbio.3001115
8625:Nature Reviews. Microbiology
8588:10.1016/j.meegid.2019.03.001
8313:"Bat coronaviruses in China"
7814:10.1016/0168-1702(87)90008-6
7716:10.1016/0378-1135(93)90126-R
7659:10.1007/978-1-4684-5823-7_66
7068:Emerging Infectious Diseases
6744:Clinical Infectious Diseases
5420:10.7861/clinmedicine.4-2-152
4994:Emerging Infectious Diseases
4943:Clinical Infectious Diseases
4892:Journal of Clinical Virology
3717:Emerging Infectious Diseases
3340:10.1016/0042-6822(64)90263-6
3154:10.1128/JVI.1.4.810-816.1967
2414:(3996): 726–727. June 1946.
1775:Beach JR, Schalm OW (1936).
1626:10.1126/science.76.1958.34-a
1351:"A history of coronaviruses"
674:in London who had recruited
381:infectious laryngotracheitis
249:) was discovered in 1947 at
7:
3514:Journal of General Virology
3416:The Journal of Cell Biology
3367:The Journal of Cell Biology
2259:Microbiology and Immunology
2091:"A hepatitis virus of mice"
1837:Journal of General Virology
1535:Schalk AF, Hawn MC (1931).
1416:10.1007/978-3-642-65775-7_3
1252:most recent common ancestor
999:), Chinese ferret-badgers (
693:Journal of General Virology
492:Christopher Howard Andrewes
236:infectious bronchitis virus
10:
9153:
8054:(inactive 30 March 2024).
7538:10.1016/j.cvsm.2004.10.011
7424:10.1177/030098586800500112
7381:10.1177/030098586600300309
6860:10.26719/2013.19.supp1.S12
5727:10.1007/s15010-020-01401-y
5169:10.1016/j.prrv.2004.07.009
4199:10.1177/030098587301000105
3107:10.3181/00379727-121-30734
2477:10.1177/003591576605900727
2182:10.3181/00379727-100-24810
1726:Beach JR (November 1931).
1212:other European countries.
1193:acute infectious diarrhoea
1115:Other animal coronaviruses
1062:intermediate horseshoe bat
863:in 2009 into four genera,
696:, in which they concluded:
608:Discovery of the structure
558:antigen-antibody reactions
459:, which was discovered by
302:-like projections (called
16:History of the virus group
8973:10.1186/s12985-016-0544-0
8637:10.1038/s41579-018-0118-9
8480:10.1016/j.tim.2016.09.001
8187:10.2478/jvetres-2019-0064
8006:10.1186/s12985-015-0421-2
7520:Hartmann, Katrin (2005).
7265:Mcclurkin, A. W. (1965).
7030:10.1007/s00705-016-2977-6
6708:10.1038/s41586-020-2312-y
6651:10.1038/s41586-020-2169-0
6586:10.1038/s41586-020-2313-x
6528:10.1016/j.cub.2020.03.022
6462:10.1038/s41564-020-0771-4
6258:10.1038/s41591-020-0820-9
6209:10.1038/s41586-020-2012-7
6152:10.1016/j.cub.2020.05.023
6104:10.1038/s41586-020-2169-0
6047:10.1038/s41586-020-2313-x
5989:10.1016/j.cub.2020.03.022
5852:10.1038/s41564-020-0695-z
5649:10.3390/healthcare8010051
5151:Cherry, James D. (2004).
4905:10.1016/j.jcv.2005.09.008
4468:10.1007/s00705-009-0547-x
3950:Bradburne, A. F. (1970).
3753:"Virology: Coronaviruses"
3713:"Etymologia: Coronavirus"
3527:10.1099/0022-1317-1-2-175
3056:(Supplement): S223–S227.
2889:10.3109/00016486409134552
1850:10.1099/0022-1317-68-1-57
1025:Infection with SARS-CoV-2
976:World Health Organization
892:Other human coronaviruses
846:(discovered in 2000) and
840:Human enteric coronavirus
782:(discovered in 1970) and
657:National Cancer Institute
545:David Arthur John Tyrrell
527:Common Cold Research Unit
507:National Cancer Institute
415:Gallid alphaherpesvirus 1
387:chicks" published in the
8917:(6): Online (00473-12).
7342:The Cornell Veterinarian
6806:10.3389/fvets.2020.00379
6357:10.3390/pathogens9070529
5943:Johns Hopkins University
4450:Carstens, E. B. (2010).
3219:The Cornell Veterinarian
3191:The Cornell Veterinarian
2459:Andrewes C (July 1966).
2372:10.1093/infdis/126.2.123
1921:Theiler M (April 1937).
1477:10.33493/scivis.20.01.04
1011:Nyctereutes procyonoides
986:in 2004, and renamed it
786:(discovered in 1982) as
680:Ontario Cancer Institute
627:The Cornell Veterinarian
541:that cause common cold.
519:Medical Research Council
418:.) They concluded that:
223:history of coronaviruses
8281:10.1126/science.1085953
7927:(October Suppl): 72–73.
7704:Veterinary Microbiology
5598:10.1073/pnas.0506735102
5538:10.1126/science.1118391
5478:10.1126/science.1087139
4658:10.1073/pnas.0400762101
4005:British Medical Journal
3305:10.1093/infdis/100.1.74
3013:10.1136/bmj.1.5448.1467
3001:British Medical Journal
2828:British Medical Journal
2703:British Medical Journal
1458:Lalchhandama K (2020).
1358:WikiJournal of Medicine
1327:WikiJournal of Medicine
818:Human respiratory virus
792:Human respiratory virus
643:University of Cambridge
563:British Medical Journal
310:293 million years ago.
128:Epidemics and pandemics
8468:Trends in Microbiology
7987:Lee, Changhee (2015).
7587:10.1006/viro.1998.9045
7412:Pathologia Veterinaria
7369:Pathologia Veterinaria
7336:Holzworth, J. (1963).
7080:10.3201/eid1911.131172
6307:10.1093/molbev/msaa162
5006:10.3201/eid1205.051316
4509:. 2021. Archived from
4048:Fenner, Frank (1976).
4017:10.1136/bmj.1.5592.606
3809:Monographs in Virology
3729:10.3201/eid2605.ET2605
3711:Henry, Ronnie (2020).
2877:Acta Oto-Laryngologica
2715:10.1136/bmj.1.5223.393
2563:10.1098/rsbm.2007.0014
1239:
1222:University of Maryland
1094:Erasmus Medical Center
947:Zoonotic coronaviruses
933:Human coronavirus HKU1
898:Human coronavirus NL63
842:(discovered in 1975),
838:(discovered in 1973),
834:(discovered in 1962),
827:Human coronavirus OC43
822:Human coronavirus 229E
797:Human coronavirus 229E
784:Puffinosis coronavirus
776:Mouse hepatitis virus,
761:
748:
729:
714:
703:
667:
653:
632:University of Kentucky
623:University of Maryland
617:
585:
573:
465:Rockefeller Foundation
448:Harvard Medical School
431:
402:
351:
251:Harvard Medical School
181:History of coronavirus
8923:10.1128/mBio.00473-12
8530:10.3390/genes11060605
8052:10.1136/vr.100.12.243
6901:10.1056/NEJMoa1211721
5200:WHO (16 March 2003).
4594:(11 Suppl): 223–227.
3800:Wildy, Peter (1971).
3579:10.1073/pnas.57.4.933
3477:10.1084/jem.118.3.327
2951:Monto, A. S. (1974).
2840:10.1136/bmj.2.5297.82
2033:10.1093/jnci/20.5.879
1655:Beaudette FR (1937).
1371:10.15347/WJM/2022.005
1256:genetic recombination
1234:
1058:Rhinolophus malayanus
1054:Malayan horseshoe bat
756:
743:
720:
708:
698:
684:University of Toronto
665:
648:
615:
589:University of Chicago
577:
568:
535:parainfluenza viruses
496:mouse hepatitis virus
420:
397:
349:
306:) on their surfaces.
284:University of Chicago
265:(MHV), later renamed
263:mouse hepatitis virus
9074:10.1128/JVI.01926-07
8735:10.1128/JVI.03273-12
8686:10.1128/JVI.06540-11
8101:Archives of Virology
7851:Archives of Virology
7201:(10229): 1063–1077.
7168:10.1056/NEJMc1409847
7129:10.1056/NEJMc1409847
7018:Archives of Virology
6973:10.1128/JVI.01244-13
5901:10.1056/NEJMc2004973
5350:10.1056/NEJMoa030781
5299:10.1056/NEJMoa030634
5049:(12): 241–246, 248.
4855:10.1128/JCM.02614-05
4757:10.1128/JVI.00906-12
4456:Archives of Virology
4186:Veterinary Pathology
3857:Archives of Virology
3618:Archives of Virology
3428:10.1083/jcb.16.3.616
2229:10.1093/jnci/27.1.29
1988:10.1084/jem.90.3.195
1939:10.1084/jem.65.5.705
1890:10.1084/jem.90.3.181
1744:10.1084/jem.54.6.809
1331:academic peer review
1246:Evolutionary history
926:Perimyotis subflavus
676:June Dalziel Almeida
9137:History of virology
9062:Journal of Virology
8862:Journal of Virology
8785:10.1292/jvms.69.301
8723:Journal of Virology
8674:Journal of Virology
8580:2019InfGE..71...21L
8272:2003Sci...300.1399M
8266:(5624): 1399–1404.
7753:Journal of Virology
6961:Journal of Virology
6923:WHO (23 May 2013).
6853:(Suppl 1): S12–18.
6756:10.1093/cid/ciaa325
6699:2020Natur.583..830B
6642:2020Natur.583..282L
6577:2020Natur.583..286X
6520:2020CBio...30E1346Z
6449:Nature Microbiology
6201:2020Natur.579..270Z
6144:2020CBio...30E2196Z
6095:2020Natur.583..282L
6038:2020Natur.583..286X
5981:2020CBio...30E1346Z
5840:Nature Microbiology
5589:2005PNAS..10214040L
5583:(39): 14040–14045.
5529:2005Sci...310..676L
5469:2003Sci...302..276G
5243:(9366): 1319–1325.
5111:(9393): 1353–1358.
4794:Journal of Virology
4751:(23): 12816–12825.
4745:Journal of Virology
4649:2004PNAS..101.6212F
4507:talk.ictvonline.org
3769:1968Natur.220..650.
3763:(5168): 650. 1968.
3668:Journal of Virology
3570:1967PNAS...57..933M
3379:10.1083/jcb.24.1.57
3142:Journal of Virology
2883:(Sup188): 138–144.
2420:1946Natur.157R.726.
1618:1932Sci....76...34H
800:(HCoV-229E) in 2009
481:John Howard Mueller
364:respiratory disease
255:John Howard Mueller
8113:10.1007/BF01317606
7863:10.1007/BF01310494
6407:10.1111/tbed.13577
4513:on 16 January 2020
4420:10.3181/0903-MR-94
3968:10.1007/BF01253769
3869:10.1007/BF01341722
3632:10.1007/BF01242962
2871:Hoorn, B. (1964).
2323:10.1007/BF01253764
1794:10.3382/ps.0150199
1712:10.3382/ps.0120055
1674:10.3382/ps.0160103
1175:Alphacoronavirus 1
1170:Canine coronavirus
1164:Canine coronavirus
1156:Feline coronavirus
1121:Alphacoronavirus 1
1070:intermediate hosts
993:masked palm civets
881:Orthocoronavirinae
844:Equine coronavirus
836:Bovine coronavirus
824:(HCoV-OC229E) and
788:Murine coronavirus
715:
668:
639:Glaxo Laboratories
637:D.M. Berry at the
618:
523:Ministry of Health
352:
268:Murine coronavirus
8729:(12): 7039–7045.
8431:10.1093/ve/vex012
8381:10.3390/v11020174
8330:10.3390/v11030210
8040:Veterinary Record
7668:978-1-4684-5825-1
7162:(14): 1359–1360.
7123:(14): 2499–2505.
7074:(11): 1819–1823.
7024:(10): 2921–2949.
6967:(14): 7790–7792.
6894:(19): 1814–1820.
6693:(7818): 830–833.
6636:(7815): 282–285.
6571:(7815): 286–289.
6455:(11): 1408–1417.
6195:(7798): 270–273.
6138:(11): 2196–2203.
6089:(7815): 282–285.
6032:(7815): 286–289.
5895:(16): 1564–1567.
5777:10.3390/v12020135
5523:(5748): 676–679.
5463:(5643): 276–278.
5408:Clinical Medicine
5343:(20): 1953–1966.
5292:(20): 1995–2005.
4643:(16): 6212–6216.
4413:(10): 1117–1127.
4290:(12): 4523–4526.
4241:(7942): 953–954.
4067:10.1159/000149938
4011:(5592): 606–610.
3231:2027/uc1.b4179375
3007:(5448): 1467–70.
2144:10.1159/000160249
2068:10.1159/000160248
1513:978-0-19-263285-2
1425:978-3-642-65777-1
1216:Bat coronaviruses
1105:Egyptian tomb bat
1074:Malayan pangolins
1046:Malayan pangolins
1002:Melogale moschata
883:under the family
853:Betacoronavirus 1
772:Avian coronavirus
711:Betacoronavirus 1
531:influenza viruses
247:encephalomyelitis
240:Avian coronavirus
219:
218:
176:Novel coronavirus
154:
146:
138:
9144:
9096:
9095:
9085:
9068:(4): 1819–1826.
9053:
9047:
9046:
9036:
9026:
9002:
8996:
8995:
8985:
8975:
8960:Virology Journal
8951:
8945:
8944:
8934:
8902:
8896:
8895:
8885:
8868:(3): 1595–1604.
8853:
8847:
8846:
8836:
8804:
8798:
8797:
8787:
8763:
8757:
8756:
8746:
8714:
8708:
8707:
8697:
8680:(7): 3995–4008.
8665:
8659:
8658:
8648:
8616:
8610:
8609:
8599:
8559:
8553:
8552:
8542:
8532:
8508:
8502:
8501:
8491:
8459:
8453:
8452:
8442:
8410:
8404:
8403:
8393:
8383:
8359:
8353:
8352:
8342:
8332:
8308:
8302:
8301:
8283:
8250:
8244:
8243:
8215:
8209:
8208:
8198:
8166:
8160:
8159:
8157:
8155:
8141:
8135:
8134:
8124:
8092:
8086:
8085:
8079:
8071:
8035:
8029:
8028:
8018:
8008:
7993:Virology Journal
7984:
7978:
7977:
7967:
7935:
7929:
7928:
7916:
7910:
7909:
7907:
7905:
7891:
7885:
7884:
7874:
7842:
7836:
7835:
7825:
7793:
7787:
7786:
7776:
7759:(5): 4508–4514.
7744:
7738:
7737:
7727:
7695:
7689:
7688:
7642:
7636:
7635:
7615:
7609:
7608:
7598:
7566:
7560:
7559:
7549:
7517:
7508:
7507:
7497:
7473:
7467:
7466:
7442:
7436:
7435:
7407:
7401:
7400:
7364:
7358:
7357:
7333:
7327:
7326:
7324:
7322:
7308:
7297:
7296:
7286:
7262:
7256:
7255:
7235:
7229:
7228:
7218:
7186:
7180:
7179:
7147:
7141:
7140:
7108:
7102:
7101:
7091:
7058:
7052:
7051:
7041:
7009:
7003:
7002:
6992:
6951:
6945:
6944:
6942:
6940:
6920:
6914:
6913:
6903:
6879:
6873:
6872:
6862:
6838:
6829:
6828:
6818:
6808:
6784:
6778:
6777:
6767:
6750:(9): 2428–2446.
6735:
6729:
6728:
6710:
6678:
6672:
6671:
6653:
6621:
6615:
6614:
6588:
6556:
6550:
6549:
6539:
6514:(7): 1346–1351.
6499:
6493:
6492:
6474:
6464:
6440:
6429:
6428:
6418:
6401:(4): 1745–1749.
6386:
6380:
6379:
6369:
6359:
6335:
6329:
6328:
6318:
6301:(9): 2463–2464.
6286:
6280:
6279:
6269:
6237:
6231:
6230:
6220:
6180:
6174:
6173:
6163:
6123:
6117:
6116:
6106:
6074:
6068:
6067:
6049:
6017:
6011:
6010:
6000:
5975:(7): 1346–1351.
5960:
5954:
5953:
5951:
5949:
5929:
5923:
5922:
5912:
5880:
5874:
5873:
5863:
5831:
5825:
5824:
5822:
5820:
5806:
5800:
5799:
5789:
5779:
5755:
5749:
5748:
5738:
5706:
5700:
5699:
5697:
5695:
5681:
5672:
5671:
5661:
5651:
5627:
5621:
5620:
5610:
5600:
5568:
5559:
5558:
5540:
5508:
5499:
5498:
5480:
5448:
5442:
5441:
5431:
5399:
5393:
5392:
5390:
5388:
5369:
5363:
5362:
5352:
5328:
5322:
5321:
5311:
5301:
5277:
5271:
5270:
5260:
5228:
5222:
5221:
5219:
5217:
5197:
5191:
5190:
5180:
5148:
5139:
5138:
5128:
5096:
5090:
5089:
5068:
5059:
5058:
5034:
5028:
5027:
5017:
4985:
4979:
4978:
4968:
4958:
4934:
4928:
4927:
4917:
4907:
4883:
4877:
4876:
4866:
4849:(6): 2063–2071.
4834:
4828:
4827:
4817:
4785:
4779:
4778:
4768:
4736:
4730:
4729:
4719:
4687:
4681:
4680:
4670:
4660:
4628:
4622:
4621:
4603:
4579:
4573:
4572:
4562:
4529:
4523:
4522:
4520:
4518:
4499:
4490:
4489:
4479:
4447:
4441:
4440:
4422:
4398:
4392:
4391:
4389:
4387:
4373:
4367:
4366:
4356:
4324:
4318:
4317:
4307:
4275:
4269:
4268:
4258:
4226:
4220:
4219:
4201:
4177:
4171:
4170:
4160:
4136:
4130:
4129:
4127:
4125:
4111:
4105:
4104:
4102:
4100:
4086:
4080:
4079:
4069:
4045:
4039:
4038:
4028:
3996:
3990:
3989:
3979:
3962:(3–4): 352–364.
3947:
3941:
3940:
3938:
3936:
3922:
3916:
3915:
3913:
3911:
3897:
3891:
3890:
3880:
3848:
3842:
3841:
3839:
3837:
3823:
3817:
3816:
3806:
3797:
3791:
3790:
3788:
3777:10.1038/220650b0
3749:
3743:
3742:
3740:
3708:
3702:
3701:
3691:
3674:(5): 1019–1027.
3659:
3653:
3652:
3634:
3625:(3–4): 417–425.
3608:
3602:
3601:
3591:
3581:
3549:
3540:
3539:
3529:
3505:
3499:
3498:
3488:
3456:
3450:
3449:
3439:
3407:
3401:
3400:
3390:
3358:
3352:
3351:
3323:
3317:
3316:
3284:
3278:
3277:
3249:
3243:
3242:
3213:
3207:
3206:
3182:
3176:
3175:
3165:
3133:
3127:
3126:
3090:
3084:
3083:
3065:
3041:
3035:
3034:
3024:
2992:
2983:
2982:
2972:
2948:
2942:
2941:
2931:
2907:
2901:
2900:
2868:
2862:
2861:
2851:
2819:
2813:
2812:
2784:
2778:
2777:
2767:
2743:
2737:
2736:
2726:
2694:
2688:
2687:
2670:(7118): 239–42.
2659:
2653:
2652:
2624:
2618:
2617:
2589:
2583:
2582:
2546:
2540:
2539:
2529:
2505:
2499:
2498:
2488:
2456:
2450:
2449:
2431:
2429:10.1038/157726b0
2400:
2394:
2393:
2383:
2351:
2345:
2344:
2334:
2317:(3–4): 293–302.
2302:
2293:
2292:
2282:
2250:
2241:
2240:
2208:
2202:
2201:
2165:
2156:
2155:
2127:
2121:
2120:
2110:
2086:
2080:
2079:
2051:
2045:
2044:
2016:
2010:
2009:
1999:
1967:
1961:
1960:
1950:
1918:
1912:
1911:
1901:
1869:
1863:
1862:
1852:
1828:
1822:
1821:
1805:
1799:
1798:
1796:
1772:
1766:
1765:
1755:
1723:
1717:
1716:
1714:
1690:
1679:
1678:
1676:
1652:
1646:
1645:
1601:
1595:
1594:
1558:
1549:
1548:
1532:
1526:
1525:
1497:
1482:
1481:
1479:
1455:
1430:
1429:
1403:
1391:
1373:
1355:
1346:
1335:reviewer reports
1324:
1297:Deltacoronavirus
1293:Gammacoronavirus
1285:Alphacoronavirus
1281:Deltacoronavirus
1277:Gammacoronavirus
1269:Alphacoronavirus
1230:Myotis lucifugus
1203:Ghent University
1041:
1035:
877:Gammacoronavirus
873:Deltacoronavirus
865:Alphacoronavirus
770:(but renamed to
594:Orthomyxoviridae
525:established the
314:species such as
211:
204:
197:
152:
144:
136:
116:COVID-19 vaccine
63:Deltacoronavirus
58:Gammacoronavirus
48:Alphacoronavirus
33:
19:
18:
9152:
9151:
9147:
9146:
9145:
9143:
9142:
9141:
9102:
9101:
9100:
9099:
9054:
9050:
9017:(3): e3001115.
9003:
8999:
8952:
8948:
8903:
8899:
8854:
8850:
8805:
8801:
8764:
8760:
8715:
8711:
8666:
8662:
8617:
8613:
8560:
8556:
8509:
8505:
8460:
8456:
8419:Virus Evolution
8411:
8407:
8360:
8356:
8309:
8305:
8251:
8247:
8232:10.2307/3223962
8216:
8212:
8167:
8163:
8153:
8151:
8143:
8142:
8138:
8093:
8089:
8073:
8072:
8046:(12): 243–244.
8036:
8032:
7985:
7981:
7936:
7932:
7917:
7913:
7903:
7901:
7893:
7892:
7888:
7843:
7839:
7794:
7790:
7745:
7741:
7696:
7692:
7669:
7643:
7639:
7626:(78): 359–366.
7616:
7612:
7567:
7563:
7518:
7511:
7474:
7470:
7443:
7439:
7408:
7404:
7365:
7361:
7334:
7330:
7320:
7318:
7310:
7309:
7300:
7263:
7259:
7236:
7232:
7187:
7183:
7148:
7144:
7109:
7105:
7059:
7055:
7010:
7006:
6952:
6948:
6938:
6936:
6921:
6917:
6880:
6876:
6839:
6832:
6785:
6781:
6736:
6732:
6679:
6675:
6622:
6618:
6557:
6553:
6508:Current Biology
6500:
6496:
6441:
6432:
6387:
6383:
6336:
6332:
6287:
6283:
6246:Nature Medicine
6238:
6234:
6181:
6177:
6132:Current Biology
6124:
6120:
6075:
6071:
6018:
6014:
5969:Current Biology
5961:
5957:
5947:
5945:
5931:
5930:
5926:
5881:
5877:
5832:
5828:
5818:
5816:
5808:
5807:
5803:
5756:
5752:
5707:
5703:
5693:
5691:
5683:
5682:
5675:
5628:
5624:
5569:
5562:
5509:
5502:
5449:
5445:
5400:
5396:
5386:
5384:
5371:
5370:
5366:
5329:
5325:
5278:
5274:
5229:
5225:
5215:
5213:
5198:
5194:
5149:
5142:
5097:
5093:
5069:
5062:
5035:
5031:
4986:
4982:
4935:
4931:
4884:
4880:
4835:
4831:
4786:
4782:
4737:
4733:
4688:
4684:
4629:
4625:
4580:
4576:
4539:Nature Medicine
4530:
4526:
4516:
4514:
4501:
4500:
4493:
4448:
4444:
4399:
4395:
4385:
4383:
4375:
4374:
4370:
4325:
4321:
4276:
4272:
4227:
4223:
4178:
4174:
4137:
4133:
4123:
4121:
4113:
4112:
4108:
4098:
4096:
4088:
4087:
4083:
4046:
4042:
3997:
3993:
3948:
3944:
3934:
3932:
3924:
3923:
3919:
3909:
3907:
3899:
3898:
3894:
3849:
3845:
3835:
3833:
3825:
3824:
3820:
3804:
3798:
3794:
3751:
3750:
3746:
3709:
3705:
3660:
3656:
3609:
3605:
3550:
3543:
3506:
3502:
3457:
3453:
3408:
3404:
3359:
3355:
3324:
3320:
3285:
3281:
3260:(48): 417–418.
3250:
3246:
3214:
3210:
3183:
3179:
3134:
3130:
3091:
3087:
3042:
3038:
2993:
2986:
2949:
2945:
2908:
2904:
2869:
2865:
2820:
2816:
2795:(7251): 320–2.
2785:
2781:
2744:
2740:
2709:(5223): 393–7.
2695:
2691:
2660:
2656:
2635:(7118): 237–9.
2625:
2621:
2600:(7118): 235–7.
2590:
2586:
2547:
2543:
2520:(2–3): 435–43.
2506:
2502:
2457:
2453:
2402:
2401:
2397:
2352:
2348:
2303:
2296:
2251:
2244:
2209:
2205:
2166:
2159:
2128:
2124:
2087:
2083:
2052:
2048:
2017:
2013:
1968:
1964:
1919:
1915:
1870:
1866:
1829:
1825:
1806:
1802:
1781:Poultry Science
1773:
1769:
1724:
1720:
1699:Poultry Science
1691:
1682:
1661:Poultry Science
1653:
1649:
1602:
1598:
1575:10.2307/1592697
1559:
1552:
1533:
1529:
1514:
1498:
1485:
1456:
1433:
1426:
1404:
1397:
1353:
1348:
1342:
1318:
1310:Betacoronavirus
1289:Betacoronavirus
1273:Betacoronavirus
1248:
1218:
1189:
1124:
1117:
1089:
1039:
1033:
964:
949:
937:
902:
894:
869:Betacoronavirus
780:Rat coronavirus
734:
610:
515:
457:Theiler's virus
440:
389:Poultry Science
344:
215:
186:
185:
166:
158:
157:
129:
121:
120:
111:
103:
102:
78:
68:
67:
53:Betacoronavirus
43:
17:
12:
11:
5:
9150:
9140:
9139:
9134:
9129:
9124:
9119:
9114:
9098:
9097:
9048:
8997:
8946:
8897:
8848:
8819:(1–2): 78–87.
8813:Virus Research
8799:
8778:(3): 301–303.
8758:
8709:
8660:
8631:(3): 181–192.
8611:
8554:
8503:
8454:
8405:
8354:
8303:
8245:
8210:
8181:(4): 465–470.
8161:
8136:
8107:(3): 243–247.
8087:
8030:
7979:
7944:Virus Research
7930:
7911:
7886:
7857:(1–2): 85–95.
7837:
7808:(4): 363–371.
7802:Virus Research
7788:
7739:
7690:
7667:
7637:
7610:
7581:(1): 150–157.
7561:
7509:
7488:(5): 153–155.
7468:
7457:(3): 368–377.
7437:
7402:
7375:(3): 255–270.
7359:
7328:
7298:
7257:
7230:
7181:
7142:
7103:
7053:
7004:
6946:
6915:
6874:
6830:
6779:
6730:
6673:
6616:
6551:
6494:
6430:
6381:
6330:
6281:
6252:(4): 450–452.
6232:
6175:
6118:
6069:
6012:
5955:
5924:
5875:
5846:(4): 536–544.
5826:
5801:
5750:
5721:(2): 155–163.
5701:
5673:
5622:
5560:
5500:
5443:
5414:(2): 152–160.
5394:
5364:
5323:
5272:
5223:
5192:
5163:(4): 262–269.
5140:
5091:
5080:(5): 350–352.
5060:
5029:
4980:
4956:10.1086/500136
4929:
4878:
4829:
4800:(2): 884–895.
4780:
4731:
4708:10.1086/428138
4702:(4): 492–498.
4682:
4623:
4574:
4551:10.1038/nm1024
4545:(4): 368–373.
4524:
4491:
4462:(1): 133–146.
4442:
4393:
4368:
4339:(2): 216–223.
4319:
4270:
4221:
4172:
4131:
4106:
4081:
4060:(1–2): 1–115.
4040:
3991:
3942:
3917:
3892:
3843:
3818:
3792:
3744:
3703:
3654:
3603:
3564:(4): 933–940.
3541:
3520:(2): 175–178.
3500:
3471:(3): 327–340.
3451:
3422:(3): 616–620.
3402:
3353:
3334:(3): 403–407.
3318:
3279:
3244:
3225:(4): 384–386.
3208:
3197:(2): 190–191.
3177:
3148:(4): 810–816.
3128:
3101:(1): 190–193.
3085:
3036:
2984:
2963:(4): 234–251.
2943:
2922:(2): 109–118.
2902:
2863:
2834:(5297): 82–6.
2814:
2779:
2738:
2689:
2654:
2619:
2584:
2541:
2500:
2451:
2395:
2366:(2): 123–130.
2346:
2294:
2265:(9): 825–834.
2242:
2203:
2176:(4): 875–877.
2157:
2138:(3): 298–301.
2122:
2081:
2046:
2011:
1982:(3): 195–212.
1962:
1913:
1884:(3): 181–210.
1864:
1823:
1800:
1787:(3): 199–206.
1767:
1718:
1680:
1667:(2): 103–105.
1647:
1596:
1563:Avian Diseases
1550:
1527:
1512:
1483:
1464:Science Vision
1431:
1424:
1394:
1393:
1317:
1314:
1247:
1244:
1217:
1214:
1188:
1183:
1143:Jean Holzworth
1123:
1118:
1116:
1113:
1088:
1082:
1078:Manis javanica
1050:Manis javanica
1042:million deaths
1038:more than 6.88
1015:horseshoe bats
997:Paguma larvata
963:
957:
948:
945:
936:
930:
922:tricolored bat
917:conjunctivitis
901:
895:
893:
890:
885:Coronaviridae,
794:but merged as
733:
730:
609:
606:
514:
511:
475:), indicating
439:
436:
430:
429:
425:
343:
340:
217:
216:
214:
213:
206:
199:
191:
188:
187:
184:
183:
178:
173:
167:
164:
163:
160:
159:
156:
155:
153:(2019-present)
147:
145:(2012-present)
139:
130:
127:
126:
123:
122:
119:
118:
112:
109:
108:
105:
104:
101:
100:
95:
90:
85:
79:
74:
73:
70:
69:
66:
65:
60:
55:
50:
44:
39:
38:
35:
34:
26:
25:
15:
9:
6:
4:
3:
2:
9149:
9138:
9135:
9133:
9132:Coronaviridae
9130:
9128:
9125:
9123:
9120:
9118:
9115:
9113:
9110:
9109:
9107:
9093:
9089:
9084:
9079:
9075:
9071:
9067:
9063:
9059:
9052:
9044:
9040:
9035:
9030:
9025:
9020:
9016:
9012:
9008:
9001:
8993:
8989:
8984:
8979:
8974:
8969:
8965:
8961:
8957:
8950:
8942:
8938:
8933:
8928:
8924:
8920:
8916:
8912:
8908:
8901:
8893:
8889:
8884:
8879:
8875:
8871:
8867:
8863:
8859:
8852:
8844:
8840:
8835:
8830:
8826:
8822:
8818:
8814:
8810:
8803:
8795:
8791:
8786:
8781:
8777:
8773:
8769:
8762:
8754:
8750:
8745:
8740:
8736:
8732:
8728:
8724:
8720:
8713:
8705:
8701:
8696:
8691:
8687:
8683:
8679:
8675:
8671:
8664:
8656:
8652:
8647:
8642:
8638:
8634:
8630:
8626:
8622:
8615:
8607:
8603:
8598:
8593:
8589:
8585:
8581:
8577:
8573:
8569:
8565:
8558:
8550:
8546:
8541:
8536:
8531:
8526:
8522:
8518:
8514:
8507:
8499:
8495:
8490:
8485:
8481:
8477:
8473:
8469:
8465:
8458:
8450:
8446:
8441:
8436:
8432:
8428:
8425:(1): vex012.
8424:
8420:
8416:
8409:
8401:
8397:
8392:
8387:
8382:
8377:
8373:
8369:
8365:
8358:
8350:
8346:
8341:
8336:
8331:
8326:
8322:
8318:
8314:
8307:
8299:
8295:
8291:
8287:
8282:
8277:
8273:
8269:
8265:
8261:
8257:
8249:
8241:
8237:
8233:
8229:
8225:
8221:
8214:
8206:
8202:
8197:
8192:
8188:
8184:
8180:
8176:
8172:
8165:
8150:
8146:
8140:
8132:
8128:
8123:
8118:
8114:
8110:
8106:
8102:
8098:
8091:
8083:
8077:
8069:
8065:
8061:
8057:
8053:
8049:
8045:
8041:
8034:
8026:
8022:
8017:
8012:
8007:
8002:
7998:
7994:
7990:
7983:
7975:
7971:
7966:
7961:
7957:
7953:
7949:
7945:
7941:
7934:
7926:
7922:
7915:
7900:
7896:
7890:
7882:
7878:
7873:
7868:
7864:
7860:
7856:
7852:
7848:
7841:
7833:
7829:
7824:
7819:
7815:
7811:
7807:
7803:
7799:
7792:
7784:
7780:
7775:
7770:
7766:
7762:
7758:
7754:
7750:
7743:
7735:
7731:
7726:
7721:
7717:
7713:
7709:
7705:
7701:
7694:
7686:
7682:
7678:
7674:
7670:
7664:
7660:
7656:
7652:
7648:
7641:
7633:
7629:
7625:
7621:
7614:
7606:
7602:
7597:
7592:
7588:
7584:
7580:
7576:
7572:
7565:
7557:
7553:
7548:
7543:
7539:
7535:
7531:
7527:
7523:
7516:
7514:
7505:
7501:
7496:
7491:
7487:
7483:
7479:
7472:
7464:
7460:
7456:
7452:
7448:
7441:
7433:
7429:
7425:
7421:
7417:
7413:
7406:
7398:
7394:
7390:
7386:
7382:
7378:
7374:
7370:
7363:
7355:
7351:
7347:
7343:
7339:
7332:
7317:
7313:
7307:
7305:
7303:
7294:
7290:
7285:
7280:
7276:
7272:
7268:
7261:
7253:
7249:
7245:
7241:
7234:
7226:
7222:
7217:
7212:
7208:
7204:
7200:
7196:
7192:
7185:
7177:
7173:
7169:
7165:
7161:
7157:
7153:
7146:
7138:
7134:
7130:
7126:
7122:
7118:
7114:
7107:
7099:
7095:
7090:
7085:
7081:
7077:
7073:
7069:
7065:
7057:
7049:
7045:
7040:
7035:
7031:
7027:
7023:
7019:
7015:
7008:
7000:
6996:
6991:
6986:
6982:
6978:
6974:
6970:
6966:
6962:
6958:
6950:
6934:
6930:
6926:
6919:
6911:
6907:
6902:
6897:
6893:
6889:
6885:
6878:
6870:
6866:
6861:
6856:
6852:
6848:
6844:
6837:
6835:
6826:
6822:
6817:
6812:
6807:
6802:
6798:
6794:
6790:
6783:
6775:
6771:
6766:
6761:
6757:
6753:
6749:
6745:
6741:
6734:
6726:
6722:
6718:
6714:
6709:
6704:
6700:
6696:
6692:
6688:
6684:
6677:
6669:
6665:
6661:
6657:
6652:
6647:
6643:
6639:
6635:
6631:
6627:
6620:
6612:
6608:
6604:
6600:
6596:
6592:
6587:
6582:
6578:
6574:
6570:
6566:
6562:
6555:
6547:
6543:
6538:
6533:
6529:
6525:
6521:
6517:
6513:
6509:
6505:
6498:
6490:
6486:
6482:
6478:
6473:
6468:
6463:
6458:
6454:
6450:
6446:
6439:
6437:
6435:
6426:
6422:
6417:
6412:
6408:
6404:
6400:
6396:
6392:
6385:
6377:
6373:
6368:
6363:
6358:
6353:
6349:
6345:
6341:
6334:
6326:
6322:
6317:
6312:
6308:
6304:
6300:
6296:
6292:
6285:
6277:
6273:
6268:
6263:
6259:
6255:
6251:
6247:
6243:
6236:
6228:
6224:
6219:
6214:
6210:
6206:
6202:
6198:
6194:
6190:
6186:
6179:
6171:
6167:
6162:
6157:
6153:
6149:
6145:
6141:
6137:
6133:
6129:
6122:
6114:
6110:
6105:
6100:
6096:
6092:
6088:
6084:
6080:
6073:
6065:
6061:
6057:
6053:
6048:
6043:
6039:
6035:
6031:
6027:
6023:
6016:
6008:
6004:
5999:
5994:
5990:
5986:
5982:
5978:
5974:
5970:
5966:
5959:
5944:
5940:
5939:
5934:
5928:
5920:
5916:
5911:
5906:
5902:
5898:
5894:
5890:
5886:
5879:
5871:
5867:
5862:
5857:
5853:
5849:
5845:
5841:
5837:
5830:
5815:
5811:
5805:
5797:
5793:
5788:
5783:
5778:
5773:
5769:
5765:
5761:
5754:
5746:
5742:
5737:
5732:
5728:
5724:
5720:
5716:
5712:
5705:
5690:
5686:
5680:
5678:
5669:
5665:
5660:
5655:
5650:
5645:
5641:
5637:
5633:
5626:
5618:
5614:
5609:
5604:
5599:
5594:
5590:
5586:
5582:
5578:
5574:
5567:
5565:
5556:
5552:
5548:
5544:
5539:
5534:
5530:
5526:
5522:
5518:
5514:
5507:
5505:
5496:
5492:
5488:
5484:
5479:
5474:
5470:
5466:
5462:
5458:
5454:
5447:
5439:
5435:
5430:
5425:
5421:
5417:
5413:
5409:
5405:
5398:
5382:
5378:
5374:
5368:
5360:
5356:
5351:
5346:
5342:
5338:
5334:
5327:
5319:
5315:
5310:
5305:
5300:
5295:
5291:
5287:
5283:
5276:
5268:
5264:
5259:
5254:
5250:
5246:
5242:
5238:
5234:
5227:
5211:
5207:
5203:
5196:
5188:
5184:
5179:
5174:
5170:
5166:
5162:
5158:
5154:
5147:
5145:
5136:
5132:
5127:
5122:
5118:
5114:
5110:
5106:
5102:
5095:
5087:
5083:
5079:
5075:
5067:
5065:
5056:
5052:
5048:
5044:
5040:
5033:
5025:
5021:
5016:
5011:
5007:
5003:
4999:
4995:
4991:
4984:
4976:
4972:
4967:
4962:
4957:
4952:
4948:
4944:
4940:
4933:
4925:
4921:
4916:
4911:
4906:
4901:
4898:(1): 99–102.
4897:
4893:
4889:
4882:
4874:
4870:
4865:
4860:
4856:
4852:
4848:
4844:
4840:
4833:
4825:
4821:
4816:
4811:
4807:
4803:
4799:
4795:
4791:
4784:
4776:
4772:
4767:
4762:
4758:
4754:
4750:
4746:
4742:
4735:
4727:
4723:
4718:
4713:
4709:
4705:
4701:
4697:
4693:
4686:
4678:
4674:
4669:
4664:
4659:
4654:
4650:
4646:
4642:
4638:
4634:
4627:
4619:
4615:
4611:
4607:
4602:
4597:
4593:
4589:
4585:
4578:
4570:
4566:
4561:
4556:
4552:
4548:
4544:
4540:
4536:
4528:
4512:
4508:
4504:
4498:
4496:
4487:
4483:
4478:
4473:
4469:
4465:
4461:
4457:
4453:
4446:
4438:
4434:
4430:
4426:
4421:
4416:
4412:
4408:
4404:
4397:
4382:
4378:
4372:
4364:
4360:
4355:
4350:
4346:
4342:
4338:
4334:
4330:
4323:
4315:
4311:
4306:
4301:
4297:
4293:
4289:
4285:
4281:
4274:
4266:
4262:
4257:
4252:
4248:
4244:
4240:
4236:
4232:
4225:
4217:
4213:
4209:
4205:
4200:
4195:
4191:
4187:
4183:
4176:
4168:
4164:
4159:
4154:
4150:
4146:
4142:
4135:
4120:
4116:
4110:
4095:
4091:
4085:
4077:
4073:
4068:
4063:
4059:
4055:
4054:Intervirology
4051:
4044:
4036:
4032:
4027:
4022:
4018:
4014:
4010:
4006:
4002:
3995:
3987:
3983:
3978:
3973:
3969:
3965:
3961:
3957:
3953:
3946:
3931:
3927:
3921:
3906:
3902:
3896:
3888:
3884:
3879:
3874:
3870:
3866:
3862:
3858:
3854:
3847:
3832:
3828:
3822:
3814:
3810:
3803:
3796:
3787:
3782:
3778:
3774:
3770:
3766:
3762:
3758:
3754:
3748:
3739:
3734:
3730:
3726:
3722:
3718:
3714:
3707:
3699:
3695:
3690:
3685:
3681:
3677:
3673:
3669:
3665:
3658:
3650:
3646:
3642:
3638:
3633:
3628:
3624:
3620:
3619:
3614:
3607:
3599:
3595:
3590:
3585:
3580:
3575:
3571:
3567:
3563:
3559:
3555:
3548:
3546:
3537:
3533:
3528:
3523:
3519:
3515:
3511:
3504:
3496:
3492:
3487:
3482:
3478:
3474:
3470:
3466:
3462:
3455:
3447:
3443:
3438:
3433:
3429:
3425:
3421:
3417:
3413:
3406:
3398:
3394:
3389:
3384:
3380:
3376:
3372:
3368:
3364:
3357:
3349:
3345:
3341:
3337:
3333:
3329:
3322:
3314:
3310:
3306:
3302:
3298:
3294:
3290:
3283:
3275:
3271:
3267:
3263:
3259:
3255:
3248:
3240:
3236:
3232:
3228:
3224:
3220:
3212:
3204:
3200:
3196:
3192:
3188:
3181:
3173:
3169:
3164:
3159:
3155:
3151:
3147:
3143:
3139:
3132:
3124:
3120:
3116:
3112:
3108:
3104:
3100:
3096:
3089:
3081:
3077:
3073:
3069:
3064:
3059:
3055:
3051:
3047:
3040:
3032:
3028:
3023:
3018:
3014:
3010:
3006:
3002:
2998:
2991:
2989:
2980:
2976:
2971:
2966:
2962:
2958:
2954:
2947:
2939:
2935:
2930:
2925:
2921:
2917:
2913:
2906:
2898:
2894:
2890:
2886:
2882:
2878:
2874:
2867:
2859:
2855:
2850:
2845:
2841:
2837:
2833:
2829:
2825:
2818:
2810:
2806:
2802:
2798:
2794:
2790:
2783:
2775:
2771:
2766:
2761:
2758:(2): 189–93.
2757:
2753:
2749:
2742:
2734:
2730:
2725:
2720:
2716:
2712:
2708:
2704:
2700:
2693:
2685:
2681:
2677:
2673:
2669:
2665:
2658:
2650:
2646:
2642:
2638:
2634:
2630:
2623:
2615:
2611:
2607:
2603:
2599:
2595:
2588:
2580:
2576:
2572:
2568:
2564:
2560:
2556:
2552:
2545:
2537:
2533:
2528:
2523:
2519:
2515:
2511:
2504:
2496:
2492:
2487:
2482:
2478:
2474:
2470:
2466:
2462:
2455:
2447:
2443:
2439:
2435:
2430:
2425:
2421:
2417:
2413:
2409:
2405:
2399:
2391:
2387:
2382:
2377:
2373:
2369:
2365:
2361:
2357:
2350:
2342:
2338:
2333:
2328:
2324:
2320:
2316:
2312:
2308:
2301:
2299:
2290:
2286:
2281:
2276:
2272:
2268:
2264:
2260:
2256:
2249:
2247:
2238:
2234:
2230:
2226:
2222:
2218:
2214:
2207:
2199:
2195:
2191:
2187:
2183:
2179:
2175:
2171:
2164:
2162:
2153:
2149:
2145:
2141:
2137:
2133:
2126:
2118:
2114:
2109:
2104:
2101:(6): 559–68.
2100:
2096:
2092:
2085:
2077:
2073:
2069:
2065:
2061:
2057:
2050:
2042:
2038:
2034:
2030:
2027:(5): 879–91.
2026:
2022:
2015:
2007:
2003:
1998:
1993:
1989:
1985:
1981:
1977:
1973:
1966:
1958:
1954:
1949:
1944:
1940:
1936:
1933:(5): 705–19.
1932:
1928:
1924:
1917:
1909:
1905:
1900:
1895:
1891:
1887:
1883:
1879:
1875:
1868:
1860:
1856:
1851:
1846:
1842:
1838:
1834:
1827:
1819:
1815:
1811:
1804:
1795:
1790:
1786:
1782:
1778:
1771:
1763:
1759:
1754:
1749:
1745:
1741:
1738:(6): 809–16.
1737:
1733:
1729:
1722:
1713:
1708:
1704:
1700:
1696:
1689:
1687:
1685:
1675:
1670:
1666:
1662:
1658:
1651:
1643:
1639:
1635:
1631:
1627:
1623:
1619:
1615:
1611:
1607:
1600:
1592:
1588:
1584:
1580:
1576:
1572:
1569:(4): 648–50.
1568:
1564:
1557:
1555:
1547:(3): 413–422.
1546:
1542:
1538:
1531:
1523:
1519:
1515:
1509:
1505:
1504:
1496:
1494:
1492:
1490:
1488:
1478:
1473:
1469:
1465:
1461:
1454:
1452:
1450:
1448:
1446:
1444:
1442:
1440:
1438:
1436:
1427:
1421:
1417:
1413:
1409:
1402:
1400:
1395:
1392:
1389:
1385:
1381:
1377:
1372:
1367:
1363:
1359:
1352:
1345:
1340:
1336:
1332:
1329:for external
1328:
1323:
1313:
1311:
1307:
1301:
1298:
1294:
1290:
1286:
1282:
1278:
1274:
1270:
1265:
1261:
1257:
1253:
1243:
1238:
1233:
1231:
1227:
1223:
1213:
1210:
1209:
1204:
1199:
1194:
1187:
1182:
1181:
1177:
1176:
1171:
1167:
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909:bronchiolitis
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807:Coroniviridae
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8148:
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8076:cite journal
8043:
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7902:. Retrieved
7898:
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7319:. Retrieved
7315:
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6928:
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5936:
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5813:
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5688:
5639:
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5385:. Retrieved
5376:
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5214:. Retrieved
5205:
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5000:(5): 775–9.
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4515:. Retrieved
4511:the original
4506:
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4445:
4410:
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4396:
4384:. Retrieved
4380:
4371:
4336:
4332:
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4287:
4283:
4273:
4238:
4234:
4224:
4192:(1): 45–64.
4189:
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4151:(3): 49–56.
4148:
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4122:. Retrieved
4118:
4109:
4097:. Retrieved
4093:
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4053:
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3933:. Retrieved
3929:
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3908:. Retrieved
3904:
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3856:
3846:
3834:. Retrieved
3830:
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3373:(1): 57–78.
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3366:
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2020:
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1339:CC-BY-SA-3.0
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539:rhinoviruses
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444:encephalitis
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393:herpes virus
388:
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300:solar corona
292:June Almeida
273:
266:
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239:
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220:
180:
8523:(6): E605.
7921:Pig Farming
7710:(1): 1–37.
7348:: 157–160.
7246:: 257–259.
6350:(7): E529.
5814:www.who.int
5689:www.who.int
4517:18 December
3863:(1): 1–13.
3723:(5): 1027.
1198:Pig Farming
1019:Rhinilophus
935:(HCoV-HKU1)
900:(HCoV-NL63)
861:Coronavirus
764:Coronavirus
461:Max Theiler
280:common cold
137:(2002–2004)
83:Common cold
9106:Categories
8374:(2): 174.
8323:(3): 210.
8226:(3): 322.
5770:(2): 135.
5636:Healthcare
5309:1807/16919
2557:: 349–63.
1316:References
1066:R. affinis
972:SARS-CoV-2
571:myxovirus.
336:SARS-CoV-2
8966:(1): 87.
8574:: 21–30.
8154:20 August
7904:18 August
7321:19 August
6981:1098-5514
6939:23 August
6725:213530398
6668:214683303
6611:218557880
6595:1476-4687
6489:214793698
6344:Pathogens
6056:1476-4687
5819:22 August
5715:Infection
5694:22 August
5642:(1): 51.
5387:22 August
5216:22 August
4386:21 August
4124:21 August
4099:17 August
3935:17 August
3910:17 August
3836:17 August
3266:0002-9645
1388:Q99522133
1380:2002-4436
1341:license (
1333:in 2020 (
1141:In 1963,
940:HCoV-HKU1
905:HCoV-NL63
856:in 2009.
727:particle.
581:myxovirus
477:hepatitis
455:, called
9092:18057240
9043:33711012
8992:27255185
8941:23170002
8892:15650185
8843:17092595
8794:17409649
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8606:30844511
8549:32486006
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8349:30832341
8290:12730501
8205:31934654
8068:45192183
8025:26689811
7974:27317168
7685:37146553
7575:Virology
7556:15627627
7504:17422139
7432:73331347
7397:12930790
7354:13961523
7293:14290945
7252:21020443
7225:32145185
7176:25271615
7137:25271614
7098:24206838
7048:27424026
6999:23678167
6933:Archived
6910:23075143
6869:23888790
6825:32582786
6774:32215622
6717:32380511
6660:32218527
6603:32380510
6546:32197085
6481:32724171
6425:32303108
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6325:32893295
6276:32284615
6227:32015507
6170:32416074
6113:32218527
6064:32380510
6007:32197085
5948:10 March
5919:32182409
5870:32123347
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5745:32072569
5668:32120965
5617:16169905
5547:16195424
5495:10608627
5487:12958366
5438:15139736
5381:Archived
5359:12690092
5318:12671061
5267:12711465
5210:Archived
5187:15531249
5135:14585636
5086:12820925
5055:12680518
5024:16704837
4975:16447108
4924:16257260
4873:16757599
4824:15613317
4775:22993147
4726:15655770
4677:15073334
4618:10654941
4610:16378050
4569:15034574
4486:19960211
4437:21900893
4429:19546349
4363:12781709
4333:Virology
4314:11101590
4216:40365985
4167:17649356
3815:: 27–73.
3649:21295037
3495:14077994
3446:14012223
3397:14286297
3348:14194135
3328:Virology
3313:13416637
3274:12976644
3239:14792981
3203:18863331
3080:10654941
3072:16378050
3031:14288084
2938:14286939
2897:14146666
2858:14455113
2809:13923371
2774:13920009
2733:13778900
2684:13840115
2649:14402042
2614:13840112
2579:73300843
2571:18543468
2536:13651924
2438:20986431
2237:13766009
2198:33553056
2190:13645751
2152:13101710
2117:14895796
2076:13101709
2041:13539633
2006:19871701
1957:19870629
1908:18137294
1762:19869961
1642:32695384
1634:17732084
1522:49976916
1384:Wikidata
1364:(1): 5.
968:SARS-CoV
953:zoonoses
741:in 2002:
521:and the
473:necrosis
428:another.
369:exudates
328:MERS-CoV
320:SARS-CoV
312:Zoonotic
165:See also
150:COVID-19
110:Vaccines
98:COVID-19
76:Diseases
9083:2258724
9034:7990310
8983:4891877
8932:3509437
8834:7114246
8744:3676139
8695:3302495
8646:7097006
8597:7106202
8576:Bibcode
8540:7348897
8489:7111218
8440:5467638
8391:6409556
8368:Viruses
8340:6466186
8317:Viruses
8298:5491256
8268:Bibcode
8260:Science
8240:3223962
8196:6950429
8122:7086830
8016:4687282
7999:: 193.
7965:7132433
7950:: 1–6.
7881:1706593
7872:7086586
7832:2829461
7823:7134191
7783:9557750
7734:8236772
7725:7117146
7677:1966440
7632:4377955
7605:9527924
7596:7131759
7547:7114919
7495:1790106
7463:6267960
7389:5958991
7284:1494364
7216:7155742
7089:3837665
7039:7086986
6990:3700179
6816:7297130
6799:: 379.
6765:7184405
6695:Bibcode
6638:Bibcode
6573:Bibcode
6537:7156161
6516:Bibcode
6416:7264586
6367:7400078
6316:7454771
6267:7095063
6218:7095418
6197:Bibcode
6161:7211627
6140:Bibcode
6091:Bibcode
6034:Bibcode
5998:7156161
5977:Bibcode
5910:7121658
5861:7095448
5787:7077245
5764:Viruses
5736:7095345
5659:7151147
5608:1236580
5585:Bibcode
5555:2971923
5525:Bibcode
5517:Science
5465:Bibcode
5457:Science
5429:4954004
5258:7112372
5178:7106085
5126:7112415
5015:3374449
4966:7107802
4915:7108338
4864:1489438
4766:3497669
4717:7199485
4645:Bibcode
4560:7095789
4477:7086975
4354:7126160
4256:7135454
4208:4584109
4158:1583410
4035:4295363
4026:1985339
3986:4321451
3977:7086994
3887:7125912
3878:7086650
3786:7086490
3765:Bibcode
3738:7181939
3698:5630226
3641:4300621
3598:5231356
3566:Bibcode
3536:4293939
3486:2137656
3437:2106233
3388:2106561
3172:4912236
3123:1314901
3115:4285768
3022:2166670
2979:4617423
2970:2595130
2929:2095265
2849:1925312
2765:2094670
2724:1953283
2527:2537755
2495:5939517
2486:1901004
2446:4112885
2416:Bibcode
2390:4559849
2381:7110018
2341:4099196
2332:7086756
2289:6261095
2108:2073177
1997:2135909
1948:2133518
1899:2135905
1859:3027249
1753:2180297
1614:Bibcode
1606:Science
1591:9876830
1583:1592697
1178:in 2009
463:at the
9090:
9080:
9041:
9031:
8990:
8980:
8939:
8929:
8890:
8883:544107
8880:
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8058:
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7195:Lancet
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6867:
6823:
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6723:
6715:
6687:Nature
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6630:Nature
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