31:
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and oversaw a USD 1 million research budget that gave grants to hundreds of scientists. In 1959, he refuted his earlier assertion, made as
Director of the ACS, that inhaling fine particles is unhealthy, and stated that smoking does not cause lung cancer and is at most a minor contributing factor. A
382:
in 1938. Little energetically developed both the lab and the ACS, and by 1944 they were shipping 9000 mice a week to other laboratories. The laboratory and all of the livestock were destroyed in the Great Bar Harbor Fire in the Fall of 1947. The lab was quickly rebuilt and most mouse strains were
434:
to change the building's name because of Little's previous support of eugenics. The C. C. Little
Science Building sign was replaced without Little's name on March 29, 2018. On April 26, 2021, the University of Maine announced that C. C. Little Hall would be renamed after
403:
decade later he stated, "there is no demonstrated causal relationship between smoking or any disease." In keeping with his earlier research, he believed that the main cause of cancer was genetic, not environmental.
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351:. He left Michigan in 1929 in order to devote himself to his research at Bar Harbor. With funding from Detroit car manufacturers, he was able to improve the facility for year-round use. He renamed it the "
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explanation for the inheritance of a trait that has apparently non-Mendelian characteristics". His observations on transplant rejection became codified into the "five laws of transplant immunology" by
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430:, were both named in his honor. In 2017, five faculty members and an undergraduate student submitted a formal request to University of Michigan President
296:, focusing on inheritance, transplants, and grafts. He also was an assistant dean and secretary to the president. In 1921, he inbred the mouse strain
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439:. In 2022 the name change was complete. The building is now formally called Beryl Warner Williams Hall, and has a new cultural exhibit in the lobby.
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Corporation. Also in 1929, he took on a part-time job as managing director of the
American Society for the Control of Cancer (later became the
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by Hugh
Auchincloss Jr* and Henry J. Winn, "American Journal of Transplantation", Volume 4 Issue 2 Page 155 - February 2004
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in 1922, becoming at age 33 the youngest university president in the country. While there he started a summer laboratory in
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1240:
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recovered from other labs around the world. By 1950, the lab was maintaining 60 inbred strains, and had developed the F
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in 1910, an M.S. in 1912, and D.Sc. in 1914 in zoology, with special focus in the new science of genetics. During
390:
His last major post, from 1954 to 1969, was as the
Scientific Director of the Scientific Advisory Board of the
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to date. His most important research occurred at
Harvard, including what some call his most brilliant work, "A
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of mice while at
Harvard. For his research, he received posthumously the 1978 Cancer Research Institute
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484:"Abbie Lathrop, the "Mouse Woman of Granby": Rodent Fancier and Accidental Genetics Pioneer"
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hybrid that became widely used for chemical testing. Little resigned in 1954.
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264:, attaining the rank of Major. Following the war he spent three years at the
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Clarence Cook Little (1888-1971): The
Genetic Basis of Transplant Immunology
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Steensma, David P.; Kyle, Robert A.; Shampo, Marc A. (November 2010).
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566:"Newsletter of the Beer, .W, ne, Main Office: 115 W. Sunrise Highway"
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544:
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229:
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469:"Why the C.C. Little Building Should be Renamed – Learn Speak Act"
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in 1964). In that role, he was a leading scientific voice of the
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786:
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585:"Group Submits Request to Rename C. C. Little Building"
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Italics denote acting or interim president (or term)
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355:" in honor of one donor, Roscoe B. Jackson of the
335:. In 1925, he left to become the President of the
1197:
682:National Academy of Sciences Biographical Memoir
652:Tobacco-related documents that mention Little.
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772:
327:Little accepted the post of President of the
209:(October 6, 1888 – December 22, 1971) was an
537:"Astuces pour en finir avec le tabac !"
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1010:
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29:
509:
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422:The C. C. Little Science Building at the
1206:Presidents of the University of Michigan
789:Presidents of the University of Michigan
608:
300:or "black 6", which is the most popular
1246:Academics from Brookline, Massachusetts
739:President of the University of Michigan
609:Flaherty, Colleen (September 7, 2017).
44:President of the University of Michigan
1198:
531:
529:
363:(ACS)) and served as President to the
1256:Presidents of the University of Maine
1034:Presidents of the University of Maine
1005:
760:
582:
248:after his secondary education at the
640:", Vol. 161, 1357–1361, August 2002.
634:C. C. Little, Cancer and Inbred Mice
672:"The strange career of C.C. Little"
526:
406:
392:Tobacco Industry Research Committee
13:
583:Basha, Riyah (September 2, 2017).
196:academic administrator, researcher
14:
1287:
1266:Noble and Greenough School alumni
829:(1869–1871, 1880–1882, 1887–1888)
656:
374:was extremely limited during the
1221:American birth control activists
1276:20th-century American academics
568:. 20 March 2007. Archived from
426:, and C. C. Little Hall at the
268:. In 1921, he helped found the
252:. Little received an A.B. from
611:"Honors for Racist Scientists"
558:
475:
461:
1:
454:
449:Eugenics in the United States
312:. Little developed the "DBA (
292:, Little began his work with
270:American Birth Control League
266:Cold Spring Harbor Laboratory
235:
1261:Smoking in the United States
1251:Tobacco in the United States
396:Council for Tobacco Research
314:Dilute, Brown and non-Agouti
228:, as well as a proponent of
7:
442:
10:
1292:
667:, 32, 1354-1356, June 1972
250:Noble and Greenough School
118:Board of Trustees (acting)
1241:Harvard University alumni
1041:
796:
745:
735:
722:
716:Harold Sherburne Boardman
712:
702:
694:
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380:National Cancer Institute
365:American Eugenics Society
283:
240:C. C. Little was born in
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192:
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124:
112:
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89:
77:
60:
49:
41:
37:
28:
21:
1236:American segregationists
928:James Johnson Duderstadt
650:Tobacco Documents Online
541:www.tobaccodocuments.org
242:Brookline, Massachusetts
157:Brookline, Massachusetts
882:Alexander Grant Ruthven
749:Alexander Grant Ruthven
488:Mayo Clinic Proceedings
361:American Cancer Society
260:, Little served in the
84:Alexander Grant Ruthven
424:University of Michigan
337:University of Michigan
322:William B. Coley Award
262:U.S. Army Signal Corps
226:academic administrator
920:Harold Tafler Shapiro
898:Robben Wright Fleming
674:Christopher Zbrozek,
501:10.4065/mcp.2010.0647
288:While studying under
1231:American geneticists
1226:American eugenicists
1151:Hutchinson (1992–97)
848:1897–1898, 1909–1910
844:Harry Burns Hutchins
836:James Burrill Angell
827:Henry Simmons Frieze
471:. 22 September 2017.
207:Clarence Cook Little
23:Clarence Cook Little
1271:Tobacco researchers
1133:Silverman (1973–79)
856:Marion LeRoy Burton
810:Henry Philip Tappan
731:Marion LeRoy Burton
706:University of Maine
636:by James F. Crow, "
428:University of Maine
329:University of Maine
96:University of Maine
72:Marion LeRoy Burton
16:American geneticist
865:Alfred Henry Lloyd
818:Erastus Otis Haven
726:Alfred Henry Lloyd
698:Robert Judson Aley
678:September 26, 2006
676:The Michigan Daily
589:The Michigan Daily
419:at the age of 83.
372:Jackson Laboratory
353:Jackson Laboratory
254:Harvard University
246:Harvard University
187:Harvard University
130:Harold S. Boardman
67:Alfred Henry Lloyd
1193:
1192:
1161:Kennedy (2005–11)
1138:Johnson (1984–86)
1070:Fellows (1902–10)
999:
998:
755:
754:
746:Succeeded by
713:Succeeded by
704:President of the
690:Academic offices
572:on 20 March 2007.
411:Little died of a
204:
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167:December 22, 1971
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1156:Hoff (1997–2004)
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743:1925–1929
723:Preceded by
710:1922–1925
695:Preceded by
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615:Inside Higher Ed
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543:. Archived from
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417:Ellsworth, Maine
407:Death and legacy
400:tobacco industry
376:Great Depression
370:Funding for the
357:Hudson Motor Car
302:laboratory mouse
278:Lothrop Stoddard
174:Ellsworth, Maine
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139:Personal details
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967:
966:(2002–2014,
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935:
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901:
900:(1968–1979,
874:C. C. Little
873:
863:
850:, 1910–1920)
847:
825:
736:
703:
675:
664:
620:September 7,
618:. Retrieved
614:
604:
592:. Retrieved
588:
578:
570:the original
560:
549:. Retrieved
545:the original
540:
491:
487:
477:
463:
421:
413:heart attack
410:
389:
369:
326:
310:George Snell
290:W. E. Castle
287:
239:
206:
205:
169:(1971-12-22)
126:Succeeded by
103:
79:Succeeded by
51:
1216:1971 deaths
1211:1888 births
1065:(1893–1901)
978:(2014–2022)
948:(1996–2002)
930:(1988–1996)
922:(1980–1988)
892:(1951–1968)
884:(1929–1951)
876:(1925–1929)
858:(1920–1925)
838:(1871–1909)
820:(1863–1869)
812:(1852–1863)
804:(1817–1821)
594:December 8,
494:(11): e83.
415:in 1971 in
258:World War I
114:Preceded by
62:Preceded by
1200:Categories
1177:(2014–18 )
663:Obituary,
551:2019-03-21
455:References
349:euthanasia
333:Bar Harbor
236:Early life
193:Profession
182:Alma mater
150:1888-10-06
1169:(2011–14)
1146:(1986–91)
1118:(1965–68)
1110:(1958–65)
1102:(1934–58)
1094:(1925–34)
1086:(1922–25)
1078:(1911–21)
1057:(1879–93)
1049:(1871–78)
984:Santa Ono
728:(interim)
394:(renamed
306:Mendelian
108:1922–1925
104:In office
92:President
56:1925–1929
52:In office
1167:Ferguson
1092:Boardman
986:(2022– )
638:Genetics
520:21061734
443:See also
341:eugenics
230:eugenics
214:genetics
211:American
69:(acting)
1108:Elliott
1055:Fernald
511:2966381
298:C57BL/6
222:tobacco
94:of the
1175:Hunter
1084:Little
1063:Harris
957:(2002)
939:(1996)
913:(1979)
867:(1925)
518:
508:
347:, and
318:strain
284:Career
220:, and
218:cancer
176:, U.S.
159:, U.S.
1116:Young
1100:Hauck
1047:Allen
272:with
1144:Lick
1076:Aley
968:2022
902:1988
737:6th
622:2017
596:2017
516:PMID
294:mice
276:and
164:Died
144:Born
90:6th
42:6th
506:PMC
496:doi
316:)"
1202::
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528:^
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385:1
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148:(
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
