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Tick-borne disease

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days. A combination regimen of oral clindamycin and quinine has also been proven effective, but the rate of adverse reactions is significantly higher with this combination. For Powassan virus, there are no medications for treating Powassan virus infections. Medications, however, can help to relieve symptoms and prevent complications. People with severe disease are typically treated in a hospital where they may be given intravenous fluids, fever-reducing medications, breathing support, and other therapies as needed.
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preferably with recombinant antigens. While ELISA and Western blot have similar sensitivity, Western blot is more specific due to the identification of specific immunoreactive bands. Seroconversion typically occurs around two weeks after symptom onset, but false positive ELISA results can be linked to poorly reactive antibodies against specific antigens, especially in patients with other infectious and non-infectious diseases.
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diagnosis of these illnesses remains a challenge, with many TBDs presenting with similar nonspecific symptoms and diagnosis requiring a battery of assays to assess patients adequately. New advanced molecular diagnostic methods, including next-generation sequencing and metagenomics analysis, promise improved detection of novel and emerging pathogens with the ability to detect a litany of potential pathogens with a single assay.
265:(TBE) presents non-specific clinical features, making laboratory diagnosis crucial. The diagnostic process typically involves identifying specific IgM- and IgG-serum antibodies through enzyme-linked immunosorbent assay (ELISA) since these antibodies are detectable in most cases upon hospitalization. 215:
Ticks also have the potential to induce a motor illness characterized by acute, ascending flaccid paralysis. This condition can be fatal if not treated promptly, affecting both humans and animals. It is mainly associated with certain species of ticks. Symptoms typically ranges from fatigue, numbness
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worldwide. Most of these pathogens require passage through vertebrate hosts as part of their life cycle. Tick-borne infections in humans, farm animals, and companion animals are primarily associated with wildlife animal reservoirs. Many tick-borne infections in humans involve a complex cycle between
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and Rocky Mountain spotted fever, Doxycycline is the first line treatment for adults and children of all ages. For babesiosis, a combination therapy with atovaquone and azithromycin is most commonly recommended for treatment of mild to moderate babesiosis. Treatment is usually continued for 7 to 10
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Diagnosing Lyme borreliosis relies on clinical criteria, with a history of a tick bite and associated symptoms being crucial. Laboratory diagnosis follows a 'two-tiered diagnostic protocol,' involving detecting specific antibodies using methods such as immunoenzymatic assays and Western blot tests,
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Tick-borne diseases (TBD) are a major health threat in the US. The number of pathogens and the burden of disease have been increasing over the last couple decades. With improved diagnostics and surveillance, new pathogens are regularly identified, bettering our understanding of TBDs. Unfortunately,
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Crispell, Gary; Commins, Scott P.; Archer-Hartman, Stephanie A.; Choudhary, Shailesh; Dharmarajan, Guha; Azadi, Parastoo; Karim, Shahid (17 May 2019). "Discovery of Alpha-Gal-Containing Antigens in North American Tick Species Believed to Induce Red Meat Allergy". Frontiers in Immunology. 10: 1056.
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Because individual ticks can harbor more than one disease-causing agent, patients can be infected with more than one pathogen at the same time, compounding the difficulty in diagnosis and treatment. As the incidence of tick-borne illnesses increases and the geographic areas in which they are found
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Diagnosing tick-borne diseases involves a dual approach. Some diagnoses rely on clinical observations and symptom analysis, while others are confirmed through laboratory tests. ticks can transmit a wide range of viruses, many of which are arboviruses. In general, specific laboratory tests are not
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For a person or pet to acquire a tick-borne disease requires that the individual gets bitten by a tick and that the tick feeds for a sufficient period of time. The feeding time required to transmit pathogens differs for different ticks and different pathogens. Transmission of the bacterium that
312:(the agent of Lyme disease). Other pathogens are much more rare. Ticks can be tested for infection using a highly specific and sensitive qPCR procedure. Several commercial labs provide this service to individuals for a fee. The Laboratory of Medical Zoology (LMZ), a nonprofit lab at the 1058:- Alpha-gal syndrome is likely caused by a hypersensitivity reaction to the Alpha-gal (Galactose-alpha-1,3-galactose) sugar molecule introduced by ticks while feeding on a human host. The immune reaction can leave people with an allergy to red meat and other mammalian derived products. 2040:
Czupryna, Piotr; Tarasow, Eugeniusz; Moniuszko-Malinowska, Anna; Pancewicz, Sławomir; Zajkowska, Olga; Targoński, Arkadiusz; Chorąży, Monika; Rutkowski, Krzysztof; Dunaj, Justyna; Grygorczuk, Sambor; Kondrusik, Maciej; Zajkowska, Joanna (2016-01-02).
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Ticks tend to be more active during warmer months, though this varies by geographic region and climate. Areas with woods, bushes, high grass, or leaf litter are likely to have more ticks. Those bitten commonly experience symptoms such as body aches,
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to facilitate removal. Chemical methods to make the tick self-detach, or trying to pull the tick out with one's fingers, are not efficient methods. In Australia and New Zealand, where tick-borne infections are less common than tick reactions, the
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wildlife animal reservoirs and tick vectors. The survival and transmission of these tick-borne viruses are closely linked to their interactions with tick vectors and host cells. These viruses are classified into different families, including
316:, provides a comprehensive TickReport for a variety of human pathogens and makes the data available to the public. Those wishing to know the incidence of tick-borne diseases in their town or state can search the LMZ surveillance database. 2648:
Sharma, Surendra Raj; Choudhary, S; Vorobiov, J; Commins, SP; Shahid, Karim (7 Feb 2024). " Tick bite-induced alpha-gal syndrome and immunologic responses in an alpha-gal deficient murine model" . Frontiers in Immunology. 10: 1056.
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Ticks should be removed as soon as safely possible once discovered. They can be removed either by grasping tweezers as close to the mouth as possible and pulling without rotation; some companies market grooved tools that rotate the
117:. Tick populations are also affected by changes in the populations of their hosts (e.g. deer, cattle, mice, lizards) and those hosts' predators (e.g. foxes). Diversity and availability of hosts and predators can be affected by 273:
Patients with Lyme disease who are treated with appropriate antibiotics usually recover rapidly and completely. Antibiotics commonly used include doxycycline, amoxicillin, or cefuroxime axetil. For
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Zhao, Guo-Ping; Wang, Yi-Xing; Fan, Zheng-Wei; Ji, Yang; Liu, Ming-jin; Zhang, Wen-Hui; Li, Xin-Lou; Zhou, Shi-Xia; Li, Hao; Liang, Song; Liu, Wei; Yang, Yang; Fang, Li-Qun (17 February 2021).
207:, tick-to-animal transmission is difficult to prevent because animals do not show visible symptoms; the only effective prevention relies on killing ticks on the livestock production facility. 306:
For an individual to acquire infection, the feeding tick must also be infected. Not all ticks are infected. In most places in the US, 30-50% of deer ticks will be infected with
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transmission rates to humans via tick bite are not well established but Bartonella is common in ticks. For example: 4.76% of 2100 ticks tested in a study in Germany
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The experimental confirmation and investigation of how tick bites contribute to the development of AGS have been established and examined using a mouse model.
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Symptoms: Relapsing fever typically presents as recurring high fevers, flu-like symptoms, headaches, and muscular pain, with less common symptoms including
2852: 2346:"Seroreactivity for spotted fever rickettsiae and co-infections with other tick-borne agents among habitants (sic) in central and southern Sweden" 114: 81:. The economic impact of tick-borne diseases is considered to be substantial in humans, and tick-borne diseases are estimated to affect ~80 % of 2786: 4683: 1128:"Let's Do a Tick Check - These pervasive bloodsuckers can give you more than just Lyme disease. Here's how to protect yourself. (Interactive)" 129:
expand, health workers increasingly must be able to distinguish the diverse, and often overlapping, clinical presentations of these diseases.
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Treatment: Antibiotics are the treatment for relapsing fever, with doxycycline, tetracycline, or erythromycin being the treatment of choice.
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The occurrence of ticks and tick-borne illnesses in humans is increasing. Tick populations are spreading into new areas, in part
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and at least 27 are known globally. New tick-borne diseases have been discovered in the 21st century, due in part to the use of
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Wolcott KA, Margos G, Fingerle V, Becker NS (September 2021). "Host association of Borrelia burgdorferi sensu lato: A review".
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Regions : Primarily in Africa, Spain, Saudi Arabia, Asia in and certain areas of Canada and the western United States
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Symptoms: Most often small red spots, other symptoms are fever, muscle pain, headache and respiratory problems
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in the legs, muscle aches, and, to in some cases, paralysis and other severe neurological manifestations.
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Paddock, Christopher D.; Lane, Robert S.; Staples, J. Erin; Labruna, Marcelo B. (21 September 2016).
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Pastula DM, Turabelidze G, Yates KF, Jones TF, Lambert AJ, Panella AJ, et al. (March 2014).
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Lindblom A, Wallménius K, Nordberg M, Forsberg P, Eliasson I, Påhlson C, Nilsson K (March 2013).
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As of 2020 18 tick-borne pathogens have been identified in the United States according to the
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Brites-Neto, José; Duarte, Keila Maria Roncato; Martins, Thiago Fernandes (12 March 2015).
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Brites-Neto, José; Duarte, Keila Maria Roncato; Martins, Thiago Fernandes (12 March 2015).
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by freezing and then leaving them to fall out to prevent allergic/anaphylactic reactions.
8: 5033: 5023: 4989: 4594: 4032: 3868: 3679: 3298: 3094: 3039: 2884: 2551: 2301: 1375: 847: 794: 2689: 2662: 2043:"MRI and planimetric CT follow-up study of patients with severe tick-borne encephalitis" 1619: 1225: 4757: 4752: 4661: 4641: 4275: 4118: 3937: 3903: 3453: 2837: 2821: 2794: 2568: 2468: 2443: 2419: 2394: 2370: 2345: 2078: 1873: 1846: 1797: 1772: 1708: 1644: 1529: 1508: 1491: 1400: 1309: 1276: 1252: 1209: 1185: 1158: 1132: 904: 724: 3689: 2113: 5043: 4984: 4844: 4797: 4599: 4101: 3770: 3760: 3750: 3735: 3552: 3535: 3399: 3269: 3248: 3123: 2906: 2826: 2621: 2573: 2508: 2473: 2424: 2375: 2237: 2117: 2070: 2062: 1971: 1927: 1919: 1878: 1802: 1713: 1695: 1649: 1631: 1533: 1521: 1513: 1405: 1356: 1314: 1296: 1257: 1239: 1190: 1055: 1036: 950: 763: 712: 181: 38: 2748: 2082: 295:
is well understood to require a substantial feeding period. In general, soft ticks (
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Organism: tentatively Alongshan virus, jingmenvirus group in the flavivirus family
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available for rapid diagnosis of tick-borne diseases. Due to their seriousness,
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Parasitic Insects, Mites and Ticks: Genera of Medical and Veterinary Importance
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Surendra RS; Choudhary S; Vorobiov J; Commins SP J; Shahid Karim (2024).
2287: 2264: 1292: 873: 410: 406: 2795:"Tick Saliva and the Alpha-Gal Syndrome: Finding a Needle in a Haystack" 1175: 4859: 4834: 4802: 4579: 4560: 4550: 4538: 4385: 3997: 3969: 3795: 3755: 3102: 2592:"Chinese researchers highlight new tick-borne disease, Alongshan virus" 929: 834: 805: 800: 743: 699: 639: 588: 549: 252: 185: 91: 66: 2768: 2711: 1675: 1558:. Washington, D.C.: U.S. Department of Health and Human Services. 2020 4931: 4410: 3443: 3438: 3371: 3166: 3007: 2743: 2442:
Janecek E, Mietze A, Goethe R, Schnieder T, Strube C (October 2012).
2324: 2306: 1101: 1096: 1071: 650: 572:): Confirmed common in ticks in Sweden, Switzerland, France, and Laos 387: 296: 163: 70: 1492:"The Impacts of Climate Change on Ticks and Tick-Borne Disease Risk" 1157:
Kumar, Manish; Sharma, Aniket; Grover, Prashant (13 February 2019).
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European Journal of Clinical Microbiology & Infectious Diseases
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treatment is often justified based on clinical presentation alone.
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Mac, Stephen; da Silva, Sara R.; Sander, Beate (4 January 2019).
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therapy is needed, phenoxymethylpenicillin likely is sufficient.
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Region: Southern part of Asia, Northern Africa, Southern Europe
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Tick-Borne Diseases: Recommendations for Workers and Employers
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Ben Beard C, Nelson CA, Mead PS, Petersen LR (November 2012).
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Rodino, Kyle G; Theel, Elitza S; Pritt, Bobbi S (2020-04-01).
1456:"Lyme and other tick-borne diseases are on the rise. But why?" 1337:"Tick-borne infections of animals and humans: a common ground" 4155: 2491:
Dobler G (January 2010). "Zoonotic tick-borne flaviviruses".
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therapy, typically consisting of doxycycline or tetracycline
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CIDRAP - Center for Infectious Disease Research and Policy
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Changing paradigms for tick-borne diseases in the Americas
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Tick-Borne Disease Working Group. 2020 Report to Congress
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Severe febrile illness, headaches, coma in 1/3 patients
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Australasian Society of Clinical Immunology and Allergy
752:. Lineage 2 POWV is also known as deer tick virus (DTV) 677:
Region (US): Southeast, South-central, West, widespread
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recommends seeking medical assistance or killing ticks
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Australasian Society of Clinical Immunology and Allergy
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Rahlenbeck S, Fingerle V, Doggett S (September 2016).
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Region: Inner Mongolia but potentially more widespread
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A tick crawling on a human head in a wooded area near
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bites. They are caused by infection with a variety of
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National Institute for Occupational Safety and Health
2701: 1676:"Discovery and Surveillance of Tick-Borne Pathogens" 599:(formerly human granulocytic ehrlichiosis or HGE) 348:Vector: at least 15 species of ticks in the genus 1604:"Mapping ticks and tick-borne pathogens in China" 1207: 1156: 5058: 2799:Frontiers in Cellular and Infection Microbiology 1895: 1773:"Prevention of tick-borne diseases: an overview" 2339: 2337: 2335: 2333: 2771:—National Center for Infectious Diseases (CDC) 1950:"Removal of ticks: a review of the literature" 1424:"Lyme and Other Tickborne Diseases Increasing" 3721: 3355: 2853: 2277: 2254: 1674:Tokarz, Rafal; Lipkin, W. Ian (1 July 2021). 1601: 1275:Rochlin, Ilia; Toledo, Alvaro (1 June 2020). 1274: 891:Region: Missouri and Tennessee, United States 799:Organism: Colorado tick fever virus (CTF), a 2330: 1990:"New Animation - How to Safely Remove Ticks" 1673: 789:Endemic to: North America and eastern Russia 3075:Severe fever with thrombocytopenia syndrome 2556:MMWR. Morbidity and Mortality Weekly Report 1545: 1543: 1119: 3362: 3348: 2860: 2846: 2777:—Massachusetts Department of Public Health 2651:https://doi.org/10.3389/fimmu.2023.1336883 1943: 1941: 1898:"Tick-Borne Diseases in the United States" 1747:Centers for Disease Control and Prevention 633:Region (US): South Atlantic, South-central 2820: 2810: 2688: 2678: 2567: 2467: 2418: 2369: 1965: 1913: 1872: 1862: 1796: 1707: 1643: 1507: 1467: 1449: 1447: 1445: 1399: 1308: 1251: 1233: 1184: 1174: 2637:https://doi.org/10.3389/fimmu.2019.01056 2095: 1813: 1540: 1082:List of diseases spread by invertebrates 162: 4436:Ear-Nose-Throat/Upper respiratory tract 3609:Access to water, sanitation and hygiene 2495:. Zoonoses: Advances and Perspectives. 2004: 1947: 1938: 1777:The British Journal of General Practice 1570: 1489: 1453: 1152: 1150: 14: 5059: 5019:Infectious disease (medical specialty) 4911:Antimicrobial resistance surveillance 2490: 2098:"Diagnosis of tick-borne encephalitis" 1667: 1483: 1442: 1341:International Journal for Parasitology 1334: 1268: 1125: 1077:Climate change and infectious diseases 3343: 3129:Southern tick-associated rash illness 2841: 2096:Holzmann, Heidemarie (1 April 2003). 402:, fatigue, and influenza-like illness 4266:Compartmental models in epidemiology 2280:"Lyme disease: Treatments and drugs" 1595: 1330: 1328: 1147: 731:Endemic to: Europe and northern Asia 379:Endemic to: The Americas and Eurasia 198:N,N-Diethyl-3-methylbenzamide (DEET) 2000:from the original on 27 March 2023. 742:Organism: Powassan virus (POWV), a 324:Major tick-borne diseases include: 24: 2793:Surendra RS; Shahid Karim (2021). 1821:"Crimean-Congo haemorrhagic fever" 1509:10.1146/annurev-ento-052720-094533 1416: 1201: 963:Region (US): Northeast, West Coast 25: 5078: 2697: 2527:"Powassan Virus | Powassan | CDC" 1325: 409:in pregnant adults and children, 285: 5015:Economics of Infectious Diseases 1490:Gilbert, Lucy (7 January 2021). 1454:Chrobak, Ula (3 February 2022). 1020:(American dog tick or wood tick) 3045:Crimean–Congo hemorrhagic fever 2642: 2628: 2602: 2584: 2543: 2519: 2484: 2435: 2386: 2312: 2294: 2271: 2248: 2213: 2166: 2160:"TickEncounter Resource Center" 2152: 2128: 2089: 2033: 1982: 1889: 1838: 1764: 1731: 1583:. National Academies Press (US) 1281:Journal of Medical Microbiology 825:Crimean-Congo hemorrhagic fever 597:Human granulocytic anaplasmosis 342:Borrelia burgdorferi sensu lato 223: 5024:Infectious disease informatics 4855:Transmission-based precautions 3055:Kemerovo tickborne viral fever 1864:10.14202/vetworld.2015.301-315 1392:10.14202/vetworld.2015.301-315 1367: 690:Tick-borne meningoencephalitis 13: 1: 4441:Chest/Lower respiratory tract 4216:Ocular (Eye) mucosal membrane 3577:Behavioral/lifestyle factors 2222:Ticks and Tick-Borne Diseases 2203:Laboratory of Medical Zoology 2178:Laboratory of Medical Zoology 2162:. University of Rhode Island. 2114:10.1016/S0264-410X(02)00819-8 2059:10.3109/23744235.2015.1083119 1680:Journal of Medical Entomology 1335:Baneth, Gad (1 August 2014). 1112: 1087:List of insect-borne diseases 988:Region (US): South, Southeast 147: 4003:Aerosol-generating procedure 3781:Silent/Subclinical infection 3481:Multidrug-resistant bacteria 2959:Rocky Mountain spotted fever 2639:. PMC 6533943. PMID 31156631 2616:. Department of Entomology, 2505:10.1016/j.vetmic.2009.08.024 2448:Emerging Infectious Diseases 2399:Emerging Infectious Diseases 2234:10.1016/j.ttbdis.2021.101766 2199:"Tick-Borne Disease Network" 1353:10.1016/j.ijpara.2014.03.011 1235:10.1371/journal.pone.0210280 1049: 1014:(Rocky Mountain wood tick), 923: 581:is the main European vector. 508:Region (US): East, Southwest 486:Rocky Mountain spotted fever 327: 268: 245: 7: 4667:Vaccine-preventable disease 4615:Monoclonal antibody therapy 2990:Relapsing fever borreliosis 2939:Spotted fever rickettsiosis 2286:. Diseases and Conditions. 2263:. Diseases and Conditions. 2207:University of Massachusetts 2182:University of Massachusetts 1496:Annual Review of Entomology 1428:Centers for Disease Control 1065: 1040:(Australian paralysis tick) 960:(western black-legged tick) 478:Several diseases caused by 319: 314:University of Massachusetts 210: 158: 154:Tick-Borne Disease Alliance 134:Centers for Disease Control 10: 5083: 4808:Respiratory source control 2680:10.3389/fimmu.2023.1336883 1967:10.2807/esw.11.33.03027-en 1948:Pitches DW (August 2006). 1628:10.1038/s41467-021-21375-1 587:Treatment: Broad-spectrum 534:Symptoms:Fever, headache, 151: 142:next-generation sequencing 4998: 4952:Global Health Initiatives 4942:Evolutionary epidemiology 4890: 4682: 4637:Post-exposure prophylaxis 4573:Antimicrobial stewardship 4531: 4518: 4423: 4314: 4296:Multiplicity of infection 4261:Basic reproduction number 4236: 4208: 4194: 4180: 4164: 4132: 4094: 4037:Percutaneous inoculation 4023: 3985: 3978: 3960: 3892: 3859: 3852: 3816: 3809: 3712: 3599: 3521:Host–pathogen interaction 3496: 3390: 3383: 3315: 3279: 3229: 3200: 3164: 3157: 3141: 3111: 3093: 3020: 2998: 2980:Baggio–Yoshinari syndrome 2970: 2892: 2883: 2876: 2812:10.3389/fcimb.2021.680264 2775:Tickborne Disease Website 2734: 2705: 2362:10.1007/s10096-012-1742-3 2320:Relapsing fever~treatment 1469:10.1146/knowable-020222-1 1126:Wenner M (11 June 2021). 1107:Ticks of domestic animals 610:Ehrlichia phagocytophilum 605:Anaplasma phagocytophilum 405:Treatment: Antibiotics – 205:World Health Organization 37: 32: 4770:Protective sequestration 4632:Pre-exposure prophylaxis 3923:Generational difference 3476:Horizontal gene transfer 3466:Antimicrobial resistance 3324:Rhipicephalus sanguineus 2949:American tick bite fever 2944:Pacific Coast tick fever 2257:"Lyme disease: Symptoms" 1915:10.1093/clinchem/hvaa040 1043:Region (Australia): East 994: 884:Vector: Lone star tick ( 683: 4957:Microbial phylogenetics 4875:Wastewater surveillance 4396:Geographic distribution 4271:Critical community size 4069:Surgical site infection 3917:Iatrogenic/Medical care 3836:Microbial translocation 3832:Endogenous reactivation 3827:Normal flora overgrowth 3776:Opportunistic infection 3548:Opportunistic infection 3085:Tick-borne encephalitis 3060:Kyasanur Forest disease 2667:Frontiers in Immunology 2493:Veterinary Microbiology 865:Severe febrile illness 558:Helvetica spotted fever 398:, cranial nerve palsy, 263:Tick-borne encephalitis 5029:Microbial bioterrorism 4652:efficacy/effectiveness 4060:Surgical intervention 3952:Breakthrough infection 3574:Genetic predisposition 3558:Susceptible individual 3405:Germ theory of disease 3220:Dermacentor variabilis 3065:Omsk hemorrhagic fever 2460:10.3201/eid1810.120390 2411:10.3201/eid1811.120675 2136:"Tick-Borne Illnesses" 1092:Mosquito-borne disease 657:Francisella tularensis 499:Dermacentor variabilis 172: 4865:Universal precautions 3823:Endogenous overgrowth 3675:Poultry and livestock 3213:Dermacentor andersoni 3191:Amblyomma triguttatum 3070:Powassan encephalitis 1789:10.3399/bjgp16X687013 1739:"Tick-Borne Diseases" 1608:Nature Communications 1011:Dermacentor andersoni 902:Vector: tick (likely 814:Dermacentor andersoni 778:Dermacentor andersoni 536:altered mental status 492:Rickettsia rickettsii 166: 152:Further information: 123:habitat fragmentation 115:due to climate change 4967:Genomic reassortment 4947:Genetic epidemiology 4786:Health communication 4714:Flattening the curve 4704:Disease surveillance 4487:Systemic/Generalized 4251:Animal disease model 3731:Asymptomatic carrier 3306:Ornithodoros moubata 3292:Ornithodoros gurneyi 3184:Amblyomma cajennense 3177:Amblyomma americanum 3095:Protozoan infections 3080:Tete orthobunyavirus 3050:Heartland bandavirus 2920:Human monocytotropic 2885:Bacterial infections 2618:University of Sydney 1293:10.1099/jmm.0.001206 1159:"Triple Tick Attack" 1034:Vector (Australia): 982:Amblyomma americanum 886:Amblyomma americanum 625:Amblyomma americanum 575:Vector/region(s)#1: 564:Rickettsia helvetica 514:Amblyomma cajennense 496:Vector: Wood tick ( 309:Borrelia burgdorferi 5067:Tick-borne diseases 5034:Pandemic prevention 4990:Viral phylodynamics 4971:Re-emerging disease 4860:Travel restrictions 4064:Postoperative wound 4033:Blood-borne disease 4015:Respiratory droplet 3927:Vertical/Congenital 3912:Nosocomial/Hospital 3869:Spillover infection 3299:Ornithodoros hermsi 3040:Colorado tick fever 2869:Tick-borne diseases 2624:. November 7, 2003. 2278:Mayo Clinic Staff. 2255:Mayo Clinic Staff. 2047:Infectious Diseases 1692:10.1093/jme/tjaa269 1620:2021NatCo..12.1075Z 1226:2019PLoSO..1410280M 1176:10.7759/cureus.4064 848:Hyalomma marginatum 795:Colorado tick fever 710:Vector: deer tick ( 425:species and ticks) 69:and other types of 52:Tick-borne diseases 4980:Selection pressure 4276:Force of infection 3904:Contagious disease 3839:Endogenous seeding 3736:Chain of infection 3660:Injection drug use 3571:Vaccination status 3454:Case fatality rate 3372:infectious disease 2916:Human granulocytic 2769:Tickborne Diseases 2735:External resources 2614:medent.usyd.edu.au 1994:www.allergy.org.au 1902:Clinical Chemistry 1133:The New York Times 1031:: East, West coast 905:Ixodes persulcatus 725:Ixodes persulcatus 173: 44:Infectious disease 33:Tick-borne disease 18:Tick-borne illness 5054: 5053: 5044:Tropical medicine 4985:Synthetic biology 4886: 4885: 4845:Social distancing 4798:Outbreak response 4419: 4418: 4246:Agent-based model 4232: 4231: 4228: 4227: 4224: 4223: 3771:Natural reservoir 3761:Infectious period 3751:Incubation period 3708: 3707: 3664:Natural disaster 3633:Tropical diseases 3616:Biodiversity loss 3553:Risk of infection 3543:Microbiome health 3536:Immunosuppression 3337: 3336: 3333: 3332: 3270:Ixodes scapularis 3249:Ixodes holocyclus 3158:Species and bites 3137: 3136: 3124:Alpha-gal allergy 3016: 3015: 2907:Boutonneuse fever 2781:Ixodes Scapularis 2758: 2757: 2653:. PMC NA. PMID NA 2622:Westmead Hospital 2454:(10): 1689–1690. 2405:(11): 1918–1919. 1954:Euro Surveillance 1460:Knowable Magazine 1430:. 21 October 2021 1056:Alpha-gal allergy 1037:Ixodes holocyclus 951:Ixodes scapularis 819:Region: US (West) 739:/deer tick virus 713:Ixodes scapularis 519:Region (Brazil): 358:Ixodes scapularis 203:According to the 49: 48: 27:Medical condition 16:(Redirected from 5074: 5039:Tropical disease 4975:Reverse zoonosis 4962:One Health Model 4791:Health education 4780:Community health 4699:Cordon sanitaire 4672:Ring vaccination 4642:Repurposed drugs 4529: 4528: 4448:Gastrointestinal 4291:Machine learning 4095:Gastrointestinal 4046:Intravenous line 3983: 3982: 3897:/Cross-infection 3884:Reverse zoonosis 3857: 3856: 3814: 3813: 3719: 3718: 3700:War and conflict 3568:Nutrition status 3531:Immunodeficiency 3388: 3387: 3364: 3357: 3350: 3341: 3340: 3256:Ixodes pacificus 3242:Ixodes cornuatus 3162: 3161: 3149:Tick infestation 3022:Viral infections 2890: 2889: 2881: 2880: 2871:and infestations 2862: 2855: 2848: 2839: 2838: 2834: 2824: 2814: 2703: 2702: 2694: 2692: 2682: 2654: 2646: 2640: 2632: 2626: 2625: 2606: 2600: 2599: 2588: 2582: 2581: 2571: 2547: 2541: 2540: 2538: 2537: 2523: 2517: 2516: 2499:(3–4): 221–228. 2488: 2482: 2481: 2471: 2439: 2433: 2432: 2422: 2390: 2384: 2383: 2373: 2341: 2328: 2316: 2310: 2298: 2292: 2291: 2275: 2269: 2268: 2252: 2246: 2245: 2217: 2211: 2210: 2195: 2186: 2185: 2170: 2164: 2163: 2156: 2150: 2149: 2147: 2146: 2132: 2126: 2125: 2093: 2087: 2086: 2037: 2031: 2030: 2028: 2026: 2016: 2008: 2002: 2001: 1986: 1980: 1979: 1969: 1960:(8): E060817.4. 1945: 1936: 1935: 1917: 1893: 1887: 1886: 1876: 1866: 1851:Veterinary World 1842: 1836: 1835: 1833: 1831: 1817: 1811: 1810: 1800: 1783:(650): 492–494. 1768: 1762: 1761: 1759: 1757: 1735: 1729: 1728: 1726: 1724: 1711: 1686:(4): 1525–1535. 1671: 1665: 1664: 1662: 1660: 1647: 1599: 1593: 1592: 1590: 1588: 1574: 1568: 1567: 1565: 1563: 1557: 1547: 1538: 1537: 1511: 1487: 1481: 1480: 1478: 1476: 1471: 1451: 1440: 1439: 1437: 1435: 1420: 1414: 1413: 1403: 1380:Veterinary World 1371: 1365: 1364: 1332: 1323: 1322: 1312: 1272: 1266: 1265: 1255: 1237: 1205: 1199: 1198: 1188: 1178: 1154: 1145: 1144: 1142: 1140: 1123: 985:(Lone star tick) 975:Cytauxzoon felis 728:(Russia + Asia)) 698:(FSME) virus, a 482:bacteria (below) 434:species such as 396:erythema migrans 392:neuroborreliosis 194:insect repellent 138:molecular assays 100:Orthomyxoviridae 30: 29: 21: 5082: 5081: 5077: 5076: 5075: 5073: 5072: 5071: 5057: 5056: 5055: 5050: 4994: 4907:Antigenic shift 4902:Antigenic drift 4893: 4882: 4746:Barrier nursing 4694:Contact tracing 4685: 4678: 4523: 4521: 4514: 4425: 4415: 4316: 4310: 4301:Serial interval 4220: 4204: 4195:Cervico-vaginal 4190: 4181:Trans-placental 4176: 4160: 4128: 4090: 4026:Vascular system 4025: 4019: 3974: 3962: 3956: 3896: 3888: 3848: 3805: 3723: 3704: 3595: 3526:Immune response 3492: 3471:Drug resistance 3415:Infectious dose 3379: 3368: 3338: 3329: 3311: 3275: 3225: 3196: 3153: 3133: 3107: 3089: 3012: 2994: 2966: 2872: 2866: 2759: 2754: 2753: 2730: 2729: 2714: 2700: 2658: 2657: 2647: 2643: 2633: 2629: 2608: 2607: 2603: 2590: 2589: 2585: 2562:(12): 270–271. 2548: 2544: 2535: 2533: 2525: 2524: 2520: 2489: 2485: 2440: 2436: 2391: 2387: 2342: 2331: 2317: 2313: 2302:Relapsing fever 2299: 2295: 2276: 2272: 2253: 2249: 2218: 2214: 2197: 2196: 2189: 2172: 2171: 2167: 2158: 2157: 2153: 2144: 2142: 2134: 2133: 2129: 2094: 2090: 2038: 2034: 2024: 2022: 2014: 2010: 2009: 2005: 1988: 1987: 1983: 1946: 1939: 1894: 1890: 1843: 1839: 1829: 1827: 1819: 1818: 1814: 1769: 1765: 1755: 1753: 1737: 1736: 1732: 1722: 1720: 1672: 1668: 1658: 1656: 1600: 1596: 1586: 1584: 1575: 1571: 1561: 1559: 1555: 1549: 1548: 1541: 1488: 1484: 1474: 1472: 1452: 1443: 1433: 1431: 1422: 1421: 1417: 1372: 1368: 1333: 1326: 1273: 1269: 1220:(1): e0210280. 1206: 1202: 1155: 1148: 1138: 1136: 1124: 1120: 1115: 1068: 1052: 997: 937:Babesia microti 926: 870:Heartland virus 773:Ix. spinipalpus 686: 419:Relapsing fever 413:in other adults 336:or borreliosis 330: 322: 288: 271: 248: 226: 213: 169:LeRoy, Michigan 161: 156: 150: 28: 23: 22: 15: 12: 11: 5: 5080: 5070: 5069: 5052: 5051: 5049: 5048: 5047: 5046: 5036: 5031: 5026: 5021: 5016: 5013: 5008: 5002: 5000: 4996: 4995: 4993: 4992: 4987: 4982: 4977: 4972: 4969: 4964: 4959: 4954: 4949: 4944: 4939: 4937:Emergent virus 4934: 4929: 4924: 4919: 4918: 4917: 4909: 4904: 4898: 4896: 4888: 4887: 4884: 4883: 4881: 4880: 4877: 4872: 4870:Vector control 4867: 4862: 4857: 4852: 4847: 4842: 4837: 4832: 4827: 4826: 4825: 4820: 4815: 4813:N95 respirator 4805: 4800: 4795: 4794: 4793: 4788: 4783: 4772: 4767: 4766: 4765: 4755: 4750: 4749: 4748: 4738: 4737: 4736: 4731: 4726: 4716: 4711: 4706: 4701: 4696: 4690: 4688: 4686:pharmaceutical 4680: 4679: 4677: 4676: 4675: 4674: 4669: 4664: 4659: 4654: 4644: 4639: 4634: 4629: 4624: 4619: 4618: 4617: 4607: 4602: 4597: 4592: 4587: 4582: 4577: 4576: 4575: 4565: 4564: 4563: 4553: 4548: 4547: 4546: 4535: 4533: 4532:Pharmaceutical 4526: 4516: 4515: 4513: 4512: 4509: 4504: 4499: 4494: 4489: 4484: 4483:Cardiovascular 4481: 4476: 4471: 4468: 4463: 4462:Nervous system 4460: 4457: 4456: 4455: 4445: 4444: 4443: 4438: 4429: 4427: 4421: 4420: 4417: 4416: 4414: 4413: 4408: 4403: 4398: 4393: 4388: 4383: 4378: 4373: 4368: 4363: 4358: 4353: 4348: 4347: 4346: 4341: 4331: 4326: 4320: 4318: 4312: 4311: 4309: 4308: 4303: 4298: 4293: 4288: 4286:Infection rate 4283: 4278: 4273: 4268: 4263: 4258: 4253: 4248: 4242: 4240: 4234: 4233: 4230: 4229: 4226: 4225: 4222: 4221: 4219: 4218: 4212: 4210: 4206: 4205: 4203: 4202: 4198: 4196: 4192: 4191: 4189: 4188: 4184: 4182: 4178: 4177: 4175: 4174: 4168: 4166: 4162: 4161: 4159: 4158: 4152: 4147: 4142: 4136: 4134: 4130: 4129: 4127: 4126: 4121: 4116: 4111: 4110: 4109: 4098: 4096: 4092: 4091: 4089: 4088: 4087: 4086: 4081: 4073: 4072: 4071: 4066: 4058: 4057: 4056: 4051: 4048: 4043: 4041:Injection site 4035: 4029: 4027: 4021: 4020: 4018: 4017: 4012: 4010:Dental aerosol 4007: 4006: 4005: 3995: 3989: 3987: 3980: 3976: 3975: 3973: 3972: 3966: 3964: 3958: 3957: 3955: 3954: 3949: 3948: 3947: 3942: 3941: 3940: 3935: 3932: 3921: 3920: 3919: 3914: 3906: 3900: 3898: 3894:Human-to-human 3890: 3889: 3887: 3886: 3881: 3876: 3871: 3865: 3863: 3854: 3850: 3849: 3847: 3846: 3840: 3837: 3834: 3829: 3824: 3820: 3818: 3811: 3807: 3806: 3804: 3803: 3798: 3793: 3791:Super-spreader 3788: 3786:Superinfection 3783: 3778: 3773: 3768: 3763: 3758: 3753: 3748: 3743: 3738: 3733: 3727: 3725: 3716: 3710: 3709: 3706: 3705: 3703: 3702: 3697: 3695:Vector control 3692: 3687: 3682: 3677: 3672: 3671: 3670: 3662: 3657: 3652: 3647: 3642: 3637: 3636: 3635: 3630: 3624:Climate zones 3622: 3620:Climate change 3617: 3614: 3611: 3605: 3603: 3597: 3596: 3594: 3593: 3592: 3591: 3588: 3585: 3584: 3583: 3575: 3572: 3569: 3566: 3563: 3555: 3550: 3545: 3540: 3539: 3538: 3533: 3523: 3518: 3513: 3508: 3502: 3500: 3494: 3493: 3491: 3490: 3485: 3484: 3483: 3478: 3473: 3463: 3462: 3461: 3456: 3451: 3446: 3436: 3434:Quorum sensing 3431: 3430: 3429: 3419: 3418: 3417: 3407: 3402: 3396: 3394: 3385: 3381: 3380: 3367: 3366: 3359: 3352: 3344: 3335: 3334: 3331: 3330: 3328: 3327: 3319: 3317: 3313: 3312: 3310: 3309: 3302: 3295: 3287: 3285: 3277: 3276: 3274: 3273: 3266: 3263:Ixodes ricinus 3259: 3252: 3245: 3237: 3235: 3227: 3226: 3224: 3223: 3216: 3208: 3206: 3198: 3197: 3195: 3194: 3187: 3180: 3172: 3170: 3159: 3155: 3154: 3152: 3151: 3145: 3143: 3139: 3138: 3135: 3134: 3132: 3131: 3126: 3121: 3119:Tick paralysis 3115: 3113: 3112:Other diseases 3109: 3108: 3106: 3105: 3099: 3097: 3091: 3090: 3088: 3087: 3082: 3077: 3072: 3067: 3062: 3057: 3052: 3047: 3042: 3037: 3032: 3026: 3024: 3018: 3017: 3014: 3013: 3011: 3010: 3004: 3002: 2996: 2995: 2993: 2992: 2987: 2982: 2976: 2974: 2968: 2967: 2965: 2964: 2963: 2962: 2956: 2954:rickettsialpox 2951: 2946: 2936: 2931: 2909: 2904: 2898: 2896: 2887: 2878: 2874: 2873: 2865: 2864: 2857: 2850: 2842: 2836: 2835: 2790: 2784: 2778: 2772: 2766: 2756: 2755: 2752: 2751: 2739: 2738: 2736: 2732: 2731: 2728: 2727: 2715: 2710: 2709: 2707: 2706:Classification 2699: 2698:External links 2696: 2656: 2655: 2641: 2627: 2601: 2583: 2542: 2518: 2483: 2434: 2385: 2356:(3): 317–323. 2329: 2311: 2293: 2284:MayoClinic.com 2270: 2261:MayoClinic.com 2247: 2212: 2187: 2165: 2151: 2127: 2088: 2032: 2012:"Tick Allergy" 2003: 1981: 1937: 1908:(4): 537–548. 1888: 1857:(3): 301–305. 1837: 1812: 1763: 1730: 1666: 1594: 1569: 1539: 1502:(1): 373–388. 1482: 1441: 1415: 1386:(3): 301–315. 1366: 1347:(9): 591–596. 1324: 1287:(6): 781–791. 1267: 1200: 1146: 1117: 1116: 1114: 1111: 1110: 1109: 1104: 1099: 1094: 1089: 1084: 1079: 1074: 1067: 1064: 1063: 1062: 1059: 1051: 1048: 1047: 1046: 1045: 1044: 1041: 1032: 1021: 1006: 1001:Tick paralysis 996: 993: 992: 991: 990: 989: 986: 977: 969:Cytauxzoonosis 966: 965: 964: 961: 946: 943:Theileria equi 925: 922: 921: 920: 919: 918: 915: 911:Ixodes ricinus 900: 894: 893: 892: 889: 882: 863: 862: 861: 858: 843: 822: 821: 820: 817: 809: 792: 791: 790: 787: 764:Ix. scapularis 753: 737:Powassan virus 734: 733: 732: 729: 719:Ixodes ricinus 708: 685: 682: 681: 680: 679: 678: 675: 663: 648: 636: 635: 634: 631: 621:Lone star tick 617: 614:Ehrlichia equi 594: 593: 592: 585: 582: 578:Ixodes ricinus 573: 566: 555: 554: 553: 546: 532: 525:Rio de Janeiro 517: 509: 506: 494: 483: 473: 472: 471: 468: 461: 458: 449: 416: 415: 414: 403: 380: 377: 374:I. persulcatus 346: 329: 326: 321: 318: 287: 286:Assessing risk 284: 270: 267: 247: 244: 225: 222: 212: 209: 160: 157: 149: 146: 56:transmitted by 47: 46: 41: 35: 34: 26: 9: 6: 4: 3: 2: 5079: 5068: 5065: 5064: 5062: 5045: 5042: 5041: 5040: 5037: 5035: 5032: 5030: 5027: 5025: 5022: 5020: 5017: 5014: 5012: 5009: 5007: 5004: 5003: 5001: 4997: 4991: 4988: 4986: 4983: 4981: 4978: 4976: 4973: 4970: 4968: 4965: 4963: 4960: 4958: 4955: 4953: 4950: 4948: 4945: 4943: 4940: 4938: 4935: 4933: 4930: 4928: 4925: 4923: 4920: 4916: 4913: 4912: 4910: 4908: 4905: 4903: 4900: 4899: 4897: 4895: 4889: 4878: 4876: 4873: 4871: 4868: 4866: 4863: 4861: 4858: 4856: 4853: 4851: 4850:Sterilization 4848: 4846: 4843: 4841: 4838: 4836: 4833: 4831: 4828: 4824: 4821: 4819: 4818:Surgical mask 4816: 4814: 4811: 4810: 4809: 4806: 4804: 4801: 4799: 4796: 4792: 4789: 4787: 4784: 4781: 4778: 4777: 4776: 4775:Public health 4773: 4771: 4768: 4764: 4761: 4760: 4759: 4756: 4754: 4751: 4747: 4744: 4743: 4742: 4739: 4735: 4732: 4730: 4727: 4725: 4722: 4721: 4720: 4717: 4715: 4712: 4710: 4707: 4705: 4702: 4700: 4697: 4695: 4692: 4691: 4689: 4687: 4681: 4673: 4670: 4668: 4665: 4663: 4660: 4658: 4655: 4653: 4650: 4649: 4648: 4645: 4643: 4640: 4638: 4635: 4633: 4630: 4628: 4627:Phage therapy 4625: 4623: 4620: 4616: 4613: 4612: 4611: 4610:Immunotherapy 4608: 4606: 4603: 4601: 4598: 4596: 4593: 4591: 4588: 4586: 4583: 4581: 4578: 4574: 4571: 4570: 4569: 4568:Antimicrobial 4566: 4562: 4559: 4558: 4557: 4554: 4552: 4549: 4545: 4542: 4541: 4540: 4537: 4536: 4534: 4530: 4527: 4525: 4517: 4510: 4508: 4505: 4503: 4500: 4498: 4495: 4493: 4490: 4488: 4485: 4482: 4480: 4477: 4475: 4472: 4469: 4467: 4464: 4461: 4459:Genitourinary 4458: 4454: 4451: 4450: 4449: 4446: 4442: 4439: 4437: 4434: 4433: 4431: 4430: 4428: 4422: 4412: 4409: 4407: 4404: 4402: 4399: 4397: 4394: 4392: 4389: 4387: 4384: 4382: 4379: 4377: 4374: 4372: 4369: 4367: 4364: 4362: 4359: 4357: 4354: 4352: 4349: 4345: 4342: 4340: 4337: 4336: 4335: 4332: 4330: 4327: 4325: 4322: 4321: 4319: 4317:in population 4313: 4307: 4304: 4302: 4299: 4297: 4294: 4292: 4289: 4287: 4284: 4282: 4281:Herd immunity 4279: 4277: 4274: 4272: 4269: 4267: 4264: 4262: 4259: 4257: 4254: 4252: 4249: 4247: 4244: 4243: 4241: 4239: 4235: 4217: 4214: 4213: 4211: 4207: 4200: 4199: 4197: 4193: 4186: 4185: 4183: 4179: 4173: 4170: 4169: 4167: 4165:Genitourinary 4163: 4157: 4153: 4151: 4148: 4146: 4143: 4141: 4138: 4137: 4135: 4131: 4125: 4122: 4120: 4117: 4115: 4112: 4108: 4107:Contamination 4105: 4104: 4103: 4100: 4099: 4097: 4093: 4085: 4082: 4080: 4077: 4076: 4075:Vector-borne 4074: 4070: 4067: 4065: 4062: 4061: 4059: 4055: 4052: 4049: 4047: 4044: 4042: 4039: 4038: 4036: 4034: 4031: 4030: 4028: 4022: 4016: 4013: 4011: 4008: 4004: 4001: 4000: 3999: 3996: 3994: 3991: 3990: 3988: 3984: 3981: 3977: 3971: 3968: 3967: 3965: 3959: 3953: 3950: 3946: 3943: 3939: 3936: 3933: 3930: 3929: 3928: 3925: 3924: 3922: 3918: 3915: 3913: 3910: 3909: 3907: 3905: 3902: 3901: 3899: 3895: 3891: 3885: 3882: 3880: 3877: 3875: 3872: 3870: 3867: 3866: 3864: 3862: 3861:Cross-species 3858: 3855: 3851: 3844: 3841: 3838: 3835: 3833: 3830: 3828: 3825: 3822: 3821: 3819: 3815: 3812: 3808: 3802: 3801:Window period 3799: 3797: 3794: 3792: 3789: 3787: 3784: 3782: 3779: 3777: 3774: 3772: 3769: 3767: 3766:Latent period 3764: 3762: 3759: 3757: 3754: 3752: 3749: 3747: 3744: 3742: 3739: 3737: 3734: 3732: 3729: 3728: 3726: 3720: 3717: 3715: 3711: 3701: 3698: 3696: 3693: 3691: 3688: 3686: 3683: 3681: 3678: 3676: 3673: 3669: 3666: 3665: 3663: 3661: 3658: 3656: 3653: 3651: 3648: 3646: 3645:Deforestation 3643: 3641: 3638: 3634: 3631: 3629: 3626: 3625: 3623: 3621: 3618: 3615: 3612: 3610: 3607: 3606: 3604: 3602: 3598: 3590:Stress levels 3589: 3586: 3582: 3579: 3578: 3576: 3573: 3570: 3567: 3564: 3561: 3560: 3559: 3556: 3554: 3551: 3549: 3546: 3544: 3541: 3537: 3534: 3532: 3529: 3528: 3527: 3524: 3522: 3519: 3517: 3514: 3512: 3509: 3507: 3504: 3503: 3501: 3499: 3495: 3489: 3486: 3482: 3479: 3477: 3474: 3472: 3469: 3468: 3467: 3464: 3460: 3457: 3455: 3452: 3450: 3447: 3445: 3442: 3441: 3440: 3437: 3435: 3432: 3428: 3425: 3424: 3423: 3422:Pathogenicity 3420: 3416: 3413: 3412: 3411: 3408: 3406: 3403: 3401: 3398: 3397: 3395: 3393: 3389: 3386: 3382: 3377: 3373: 3365: 3360: 3358: 3353: 3351: 3346: 3345: 3342: 3326: 3325: 3321: 3320: 3318: 3314: 3308: 3307: 3303: 3301: 3300: 3296: 3294: 3293: 3289: 3288: 3286: 3284: 3283: 3278: 3272: 3271: 3267: 3265: 3264: 3260: 3258: 3257: 3253: 3251: 3250: 3246: 3244: 3243: 3239: 3238: 3236: 3234: 3233: 3228: 3222: 3221: 3217: 3215: 3214: 3210: 3209: 3207: 3205: 3204: 3199: 3193: 3192: 3188: 3186: 3185: 3181: 3179: 3178: 3174: 3173: 3171: 3169: 3168: 3163: 3160: 3156: 3150: 3147: 3146: 3144: 3140: 3130: 3127: 3125: 3122: 3120: 3117: 3116: 3114: 3110: 3104: 3101: 3100: 3098: 3096: 3092: 3086: 3083: 3081: 3078: 3076: 3073: 3071: 3068: 3066: 3063: 3061: 3058: 3056: 3053: 3051: 3048: 3046: 3043: 3041: 3038: 3036: 3035:Bourbon virus 3033: 3031: 3028: 3027: 3025: 3023: 3019: 3009: 3006: 3005: 3003: 3001: 3000:Thiotrichales 2997: 2991: 2988: 2986: 2983: 2981: 2978: 2977: 2975: 2973: 2969: 2960: 2957: 2955: 2952: 2950: 2947: 2945: 2942: 2941: 2940: 2937: 2935: 2932: 2929: 2927: 2921: 2917: 2913: 2910: 2908: 2905: 2903: 2900: 2899: 2897: 2895: 2894:Rickettsiales 2891: 2888: 2886: 2882: 2879: 2875: 2870: 2863: 2858: 2856: 2851: 2849: 2844: 2843: 2840: 2832: 2828: 2823: 2818: 2813: 2808: 2804: 2800: 2796: 2791: 2788: 2785: 2782: 2779: 2776: 2773: 2770: 2767: 2764: 2761: 2760: 2750: 2746: 2745: 2741: 2740: 2737: 2733: 2726: 2722: 2721: 2717: 2716: 2713: 2708: 2704: 2695: 2691: 2686: 2681: 2676: 2672: 2668: 2664: 2652: 2645: 2638: 2631: 2623: 2619: 2615: 2611: 2605: 2597: 2593: 2587: 2579: 2575: 2570: 2565: 2561: 2557: 2553: 2546: 2532: 2528: 2522: 2514: 2510: 2506: 2502: 2498: 2494: 2487: 2479: 2475: 2470: 2465: 2461: 2457: 2453: 2449: 2445: 2438: 2430: 2426: 2421: 2416: 2412: 2408: 2404: 2400: 2396: 2389: 2381: 2377: 2372: 2367: 2363: 2359: 2355: 2351: 2347: 2340: 2338: 2336: 2334: 2326: 2322: 2321: 2315: 2308: 2304: 2303: 2297: 2289: 2285: 2281: 2274: 2266: 2262: 2258: 2251: 2243: 2239: 2235: 2231: 2228:(5): 101766. 2227: 2223: 2216: 2208: 2204: 2200: 2194: 2192: 2183: 2179: 2175: 2169: 2161: 2155: 2141: 2140:Yale Medicine 2137: 2131: 2123: 2119: 2115: 2111: 2107: 2103: 2099: 2092: 2084: 2080: 2076: 2072: 2068: 2064: 2060: 2056: 2052: 2048: 2044: 2036: 2021:. 21 May 2019 2020: 2013: 2007: 1999: 1995: 1991: 1985: 1977: 1973: 1968: 1963: 1959: 1955: 1951: 1944: 1942: 1933: 1929: 1925: 1921: 1916: 1911: 1907: 1903: 1899: 1892: 1884: 1880: 1875: 1870: 1865: 1860: 1856: 1852: 1848: 1841: 1826: 1822: 1816: 1808: 1804: 1799: 1794: 1790: 1786: 1782: 1778: 1774: 1767: 1752: 1748: 1744: 1740: 1734: 1719: 1715: 1710: 1705: 1701: 1697: 1693: 1689: 1685: 1681: 1677: 1670: 1655: 1651: 1646: 1641: 1637: 1633: 1629: 1625: 1621: 1617: 1613: 1609: 1605: 1598: 1582: 1581: 1573: 1554: 1553: 1546: 1544: 1535: 1531: 1527: 1523: 1519: 1515: 1510: 1505: 1501: 1497: 1493: 1486: 1470: 1465: 1461: 1457: 1450: 1448: 1446: 1429: 1425: 1419: 1411: 1407: 1402: 1397: 1393: 1389: 1385: 1381: 1377: 1370: 1362: 1358: 1354: 1350: 1346: 1342: 1338: 1331: 1329: 1320: 1316: 1311: 1306: 1302: 1298: 1294: 1290: 1286: 1282: 1278: 1271: 1263: 1259: 1254: 1249: 1245: 1241: 1236: 1231: 1227: 1223: 1219: 1215: 1211: 1204: 1196: 1192: 1187: 1182: 1177: 1172: 1168: 1164: 1160: 1153: 1151: 1135: 1134: 1129: 1122: 1118: 1108: 1105: 1103: 1100: 1098: 1095: 1093: 1090: 1088: 1085: 1083: 1080: 1078: 1075: 1073: 1070: 1069: 1060: 1057: 1054: 1053: 1042: 1039: 1038: 1033: 1030: 1029:D. variabilis 1026: 1023:Region (US): 1022: 1019: 1018: 1017:D. variabilis 1013: 1012: 1008:Vector (US): 1007: 1004: 1003: 1002: 999: 998: 987: 984: 983: 978: 976: 972: 971: 970: 967: 962: 959: 958: 954:(deer tick), 953: 952: 947: 945: 944: 939: 938: 933: 932: 931: 928: 927: 916: 914:), mosquitoes 913: 912: 907: 906: 901: 898: 897: 895: 890: 887: 883: 881: 880: 875: 871: 867: 866: 864: 859: 857: 855: 854:Rhipicephalus 850: 849: 844: 842: 841: 836: 832: 828: 827: 826: 823: 818: 816: 815: 810: 808: 807: 802: 798: 797: 796: 793: 788: 786: 785: 784:D. variabilis 780: 779: 774: 770: 766: 765: 760: 759: 758:Ixodes cookei 754: 751: 750: 745: 741: 740: 738: 735: 730: 727: 726: 721: 720: 715: 714: 709: 707: 706: 701: 697: 693: 692: 691: 688: 687: 676: 674: 670: 669: 668:D. variabilis 664: 662: 661:A. americanum 658: 654: 653: 652: 649: 646: 642: 641: 637: 632: 630: 629:I. scapularis 626: 622: 618: 615: 611: 607: 606: 601: 600: 598: 595: 590: 586: 583: 580: 579: 574: 571: 567: 565: 561: 560: 559: 556: 551: 547: 545: 541: 537: 533: 530: 526: 522: 518: 516: 515: 510: 507: 505: 501: 500: 495: 493: 489: 488: 487: 484: 481: 477: 474: 469: 466: 462: 459: 456: 455: 450: 448: 447:B. miyamotoi 444: 440: 437: 433: 432: 427: 426: 424: 420: 417: 412: 408: 404: 401: 397: 393: 389: 385: 381: 378: 375: 371: 367: 363: 359: 355: 351: 347: 344: 343: 338: 337: 335: 332: 331: 325: 317: 315: 311: 310: 304: 302: 298: 294: 283: 280: 276: 266: 264: 260: 256: 254: 243: 241: 237: 232: 221: 217: 208: 206: 201: 199: 196:with 20%–30% 195: 191: 187: 183: 179: 170: 165: 155: 145: 143: 139: 135: 130: 126: 124: 120: 119:deforestation 116: 111: 109: 105: 101: 97: 96:Rhabdoviridae 93: 89: 84: 80: 76: 72: 68: 64: 60: 57: 53: 45: 42: 40: 36: 31: 19: 4758:Notification 4729:Hand washing 4724:Food hygiene 4709:Disinfection 4605:Immunization 4556:Anthelmintic 4544:prophylactic 4432:Respiratory 4356:Hyperendemic 4306:WAIFW matrix 4083: 3961:Environment- 3714:Transmission 3690:Urbanization 3488:Host tropism 3384:Determinants 3370:Concepts in 3322: 3304: 3297: 3290: 3282:Ornithodoros 3280: 3268: 3261: 3254: 3247: 3240: 3230: 3218: 3211: 3201: 3189: 3182: 3175: 3165: 3142:Infestations 3030:Bhanja virus 2985:Lyme disease 2934:Scrub typhus 2925: 2912:Ehrlichiosis 2902:Anaplasmosis 2868: 2802: 2798: 2742: 2718: 2670: 2666: 2659: 2644: 2630: 2613: 2604: 2595: 2586: 2559: 2555: 2545: 2534:. Retrieved 2530: 2521: 2496: 2492: 2486: 2451: 2447: 2437: 2402: 2398: 2388: 2353: 2349: 2318: 2314: 2300: 2296: 2283: 2273: 2260: 2250: 2225: 2221: 2215: 2202: 2177: 2174:"TickReport" 2168: 2154: 2143:. Retrieved 2139: 2130: 2105: 2101: 2091: 2053:(1): 74–81. 2050: 2046: 2035: 2023:. Retrieved 2018: 2006: 1993: 1984: 1957: 1953: 1905: 1901: 1891: 1854: 1850: 1840: 1830:13 September 1828:. Retrieved 1824: 1815: 1780: 1776: 1766: 1754:. Retrieved 1742: 1733: 1721:. Retrieved 1683: 1679: 1669: 1657:. Retrieved 1611: 1607: 1597: 1585:. Retrieved 1579: 1572: 1560:. Retrieved 1551: 1499: 1495: 1485: 1473:. Retrieved 1459: 1432:. Retrieved 1427: 1418: 1383: 1379: 1369: 1344: 1340: 1284: 1280: 1270: 1217: 1213: 1203: 1169:(2): e4064. 1166: 1162: 1137:. Retrieved 1131: 1121: 1035: 1028: 1025:D. andersoni 1024: 1015: 1009: 1005:Cause: Toxin 980: 974: 957:I. pacificus 955: 949: 941: 935: 909: 903: 885: 879:Bunyaviridae 877: 852: 846: 840:Bunyaviridae 838: 812: 804: 782: 776: 772: 768: 762: 756: 749:Flaviviridae 747: 746:from family 723: 717: 711: 705:Flaviviridae 703: 702:from family 673:D. andersoni 672: 666: 660: 656: 644: 638: 628: 624: 613: 609: 603: 576: 570:R. helvetica 569: 563: 529:Minas Gerais 512: 504:D. andersoni 503: 497: 491: 479: 454:Ornithodoros 452: 446: 442: 438: 435: 429: 422: 373: 369: 366:I. pacificus 365: 361: 357: 352:, including 349: 340: 334:Lyme disease 323: 307: 305: 293:Lyme disease 289: 279:ehrlichiosis 275:Anaplasmosis 272: 261: 257: 249: 227: 224:Tick removal 218: 214: 202: 174: 131: 127: 112: 108:Flaviviridae 104:Bunyaviridae 88:Asfarviridae 65:, including 51: 50: 5011:Eradication 4922:Biosecurity 4647:Vaccination 4622:Inoculation 4600:Drug safety 4595:Combination 4522:and Control 4470:Soft tissue 4424:Anatomical 4391:Seasonality 4371:Mesoendemic 4351:Holoendemic 4344:Farr's laws 4256:Attack rate 4054:Animal bite 4050:Insect bite 3986:Respiratory 3613:Air quality 3601:Environment 3511:Comorbidity 3427:Attack rate 3410:Infectivity 3203:Dermacentor 2972:Spirochaete 2531:www.cdc.gov 2288:Mayo Clinic 2265:Mayo Clinic 2108:: S36–S40. 1825:www.who.int 1614:(1): 1075. 876:, from the 874:phlebovirus 837:, from the 645:Bartonella 548:Treatment: 436:B. hermsii, 428:Organisms: 411:doxycycline 407:amoxicillin 345:(bacterium) 4894:infections 4835:Sanitation 4803:Quarantine 4662:resistance 4580:Antiseptic 4561:Ascaricide 4551:Antifungal 4539:Antibiotic 4520:Prevention 4453:Intestinal 4386:Prevalence 4366:Inequality 4315:Occurrence 4114:Breastmilk 3998:Bioaerosol 3970:Sapronosis 3945:Horizontal 3817:Endogenous 3796:Viral load 3756:Index case 3103:Babesiosis 2926:E. ewingii 2536:2017-06-07 2145:2023-11-02 1113:References 973:Organism: 934:Organism: 930:Babesiosis 868:Organism: 835:nairovirus 829:Organism: 806:Reoviridae 801:coltivirus 744:flavivirus 722:(Europe), 700:flavivirus 694:Organism: 655:Organism: 640:Bartonella 608:(formerly 602:Organism: 589:antibiotic 562:Organism: 550:Antibiotic 490:Organism: 480:Rickettsia 443:B. duttoni 439:B. parkeri 382:Symptoms: 372:(Europe), 370:I. ricinus 362:I. dammini 339:Organism: 253:antibiotic 186:joint pain 148:Prevention 92:Reoviridae 67:rickettsia 5006:Discovery 4932:Disease X 4892:Emerging 4840:Screening 4741:Isolation 4585:Antiviral 4411:Twindemic 4361:Incidence 4238:Modelling 4201:Perinatal 4133:Cutaneous 4024:Linked to 3934:Perinatal 3853:Exogenous 3845:formation 3587:Pregnancy 3444:Endotoxin 3439:Virulence 3167:Amblyomma 3008:Tularemia 2928:infection 2789:Wikibooks 2749:emerg/584 2744:eMedicine 2325:eMedicine 2307:eMedicine 2067:2374-4235 1924:0009-9147 1700:0022-2585 1636:2041-1723 1534:231300522 1518:0066-4170 1301:0022-2615 1244:1932-6203 1102:Tibovirus 1097:Robovirus 1072:Arbovirus 1050:Allergies 924:Protozoan 833:virus, a 803:from the 769:Ix. marxi 651:Tularemia 521:SĂŁo Paulo 388:arthritis 354:deer tick 328:Bacterial 297:Argasidae 269:Treatment 246:Diagnosis 231:hypostome 63:pathogens 39:Specialty 5061:Category 4915:EARS-Net 4830:Safe sex 4782:services 4753:Lockdown 4524:measures 4426:location 4406:Syndemic 4401:Sporadic 4381:Pandemic 4376:Outbreak 4334:Epidemic 4187:Prenatal 4079:Mosquito 3963:to-human 3938:Neonatal 3931:Prenatal 3879:Zoonosis 3724:concepts 3655:Humidity 3640:Commerce 3516:Diabetes 3449:Exotoxin 2877:Diseases 2831:34354960 2690:10882631 2578:24670929 2513:19765917 2478:23017501 2429:23092626 2380:22961007 2242:34161868 2122:12628812 2083:24319392 2075:26414745 1998:Archived 1976:16966784 1932:32232463 1883:27047089 1807:27563139 1718:33313662 1654:33597544 1526:33417823 1410:27047089 1361:24846527 1319:32478654 1262:30608986 1214:PLOS ONE 1195:31016091 1066:See also 1027:: East, 979:Vector: 948:Vector: 845:Vector: 811:Vector: 755:Vector: 665:Vector: 619:Vector: 511:Vector: 451:Vector: 431:Borrelia 423:Borrelia 400:carditis 320:Examples 301:Ixodidae 211:Symptoms 159:Exposure 79:protozoa 71:bacteria 4719:Hygiene 4657:booster 4590:Asepsis 4329:Endemic 4324:Cluster 3908:Source 3843:Biofilm 3680:Poverty 3650:Ecology 3628:El Niño 3581:Smoking 3459:factors 3400:Biofilm 3376:Outline 2822:8331069 2725:D017282 2610:"Ticks" 2569:5779346 2469:3471628 2420:3559143 2371:3569577 2102:Vaccine 2025:17 July 1874:4774835 1798:5198687 1756:May 21, 1743:cdc.gov 1723:4 March 1709:8285023 1659:4 March 1645:7889899 1616:Bibcode 1587:4 March 1562:4 March 1475:4 March 1434:4 March 1401:4774835 1310:7451033 1253:6319811 1222:Bibcode 1186:6464285 1139:19 June 568:Region( 540:myalgia 457:species 376:(Asia)) 291:causes 240:in-situ 182:fatigue 75:viruses 4927:CRISPR 4879:Zoning 4734:Gloves 4145:Fomite 3979:Routes 3874:Vector 3741:Fomite 3722:Basic 3685:Travel 3565:Gender 3232:Ixodes 2924:Human 2829:  2819:  2687:  2576:  2566:  2511:  2476:  2466:  2427:  2417:  2378:  2368:  2240:  2120:  2081:  2073:  2065:  1974:  1930:  1922:  1881:  1871:  1805:  1795:  1716:  1706:  1698:  1652:  1642:  1634:  1532:  1524:  1516:  1408:  1398:  1359:  1317:  1307:  1299:  1260:  1250:  1242:  1193:  1183:  1163:Cureus 781:, and 542:, and 476:Typhus 465:rigors 350:Ixodes 190:rashes 106:, and 83:cattle 77:, and 4999:Other 4507:Fetus 4502:Mouth 4497:Tooth 4492:Blood 4479:Joint 4339:Curve 4209:Other 4156:wound 4154:Open 4124:Feces 4119:Water 3810:Modes 3668:Flood 3392:Agent 3316:Other 2079:S2CID 2015:(PDF) 1556:(PDF) 1530:S2CID 995:Toxin 856:bursa 684:Viral 384:Fever 188:, or 178:fever 4763:list 4684:Non- 4474:Bone 4466:Skin 4150:Soil 4140:Burn 4102:Food 4084:Tick 3746:Host 3506:Burn 3498:Host 2827:PMID 2720:MeSH 2620:and 2574:PMID 2509:PMID 2474:PMID 2425:PMID 2376:PMID 2238:PMID 2118:PMID 2071:PMID 2063:ISSN 2027:2023 1972:PMID 1928:PMID 1920:ISSN 1879:PMID 1832:2021 1803:PMID 1758:2009 1725:2022 1714:PMID 1696:ISSN 1661:2022 1650:PMID 1632:ISSN 1589:2022 1564:2022 1522:PMID 1514:ISSN 1477:2022 1436:2022 1406:PMID 1357:PMID 1315:PMID 1297:ISSN 1258:PMID 1240:ISSN 1191:PMID 1141:2021 872:, a 831:CCHF 696:TBEV 544:rash 140:and 121:and 59:tick 4823:PPE 4511:Eye 4172:Sex 3993:Air 3562:Age 2817:PMC 2807:doi 2685:PMC 2675:doi 2564:PMC 2501:doi 2497:140 2464:PMC 2456:doi 2415:PMC 2407:doi 2366:PMC 2358:doi 2323:at 2305:at 2230:doi 2110:doi 2055:doi 1962:doi 1910:doi 1869:PMC 1859:doi 1793:PMC 1785:doi 1704:PMC 1688:doi 1640:PMC 1624:doi 1504:doi 1464:doi 1396:PMC 1388:doi 1349:doi 1305:PMC 1289:doi 1248:PMC 1230:doi 1181:PMC 1171:doi 775:m, 716:), 627:), 612:or 502:), 364:), 5063:: 2922:, 2918:, 2825:. 2815:. 2805:. 2803:11 2801:. 2797:. 2747:: 2723:: 2683:. 2673:. 2671:14 2669:. 2665:. 2612:. 2594:. 2572:. 2560:63 2558:. 2554:. 2529:. 2507:. 2472:. 2462:. 2452:18 2450:. 2446:. 2423:. 2413:. 2403:18 2401:. 2397:. 2374:. 2364:. 2354:32 2352:. 2348:. 2332:^ 2282:. 2259:. 2236:. 2226:12 2224:. 2205:. 2201:. 2190:^ 2180:. 2176:. 2138:. 2116:. 2106:21 2104:. 2100:. 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Index

Tick-borne illness
Specialty
Infectious disease
transmitted by
tick
pathogens
rickettsia
bacteria
viruses
protozoa
cattle
Asfarviridae
Reoviridae
Rhabdoviridae
Orthomyxoviridae
Bunyaviridae
Flaviviridae
due to climate change
deforestation
habitat fragmentation
Centers for Disease Control
molecular assays
next-generation sequencing
Tick-Borne Disease Alliance

LeRoy, Michigan
fever
fatigue
joint pain
rashes

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