Lorazepam - Knowledge

1953:; its high lipid solubility means it gets absorbed with equal speed whether given orally, or rectally (nonintravenous routes are convenient outside of hospital settings), but diazepam's high lipid solubility also means it does not remain in the vascular space, but soon redistributes into other body tissues. So, it may be necessary to repeat diazepam doses to maintain peak anticonvulsant effects, resulting in excess body accumulation. Lorazepam is a different case; its low lipid solubility makes it relatively slowly absorbed by any route other than intravenously, but once injected, it will not get significantly redistributed beyond the vascular space. Therefore, lorazepam's anticonvulsant effects are more durable, thus reducing the need for repeated doses. If a person is known to usually stop convulsing after only one or two diazepam doses, it may be preferable because sedative after effects will be less than if a single dose of lorazepam is given (diazepam anticonvulsant/sedative effects wear off after 15–30 minutes, but lorazepam effects last 12–24 hours). The prolonged sedation from lorazepam may, however, be an acceptable trade-off for its reliable duration of effects, particularly if the person needs to be transferred to another facility. Although lorazepam is not necessarily better than diazepam at initially terminating seizures, lorazepam is, nevertheless, replacing diazepam as the intravenous agent of choice in status epilepticus. 1957:

intravenously will result in an earlier and higher peak serum level, with a higher relative proportion of unmetabolised (active) lorazepam. On regular administration, maximum serum levels are attained after three days. Longer-term use, up to six months, does not result in further accumulation. On discontinuation, lorazepam serum levels become negligible after three days and undetectable after about a week. Lorazepam is metabolized in the liver by conjugation into inactive lorazepam-glucuronide. This metabolism does not involve liver oxidation, so is relatively unaffected by reduced liver function. Lorazepam-glucuronide is more water-soluble than its precursor, so gets more widely distributed in the body, leading to a longer half-life than lorazepam. Lorazepam-glucuronide is eventually excreted by the kidneys, and, because of its tissue accumulation, it remains detectable, particularly in the urine, for substantially longer than lorazepam.

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greater. Long-term therapy may lead to cognitive deficits, especially in the elderly, which may only be partially reversible. The elderly metabolize benzodiazepines more slowly than younger people and are more sensitive to the adverse effects of benzodiazepines compared to younger individuals even at similar plasma levels. Additionally, the elderly tend to take more drugs which may interact or enhance the effects of benzodiazepines. Benzodiazepines, including lorazepam, have been found to increase the risk of falls and fractures in the elderly. As a result, dosage recommendations for the elderly are about half of those used in younger individuals and used for no longer than two weeks. Lorazepam may also be slower to clear in the elderly, leading potentially to accumulation and enhanced effects. Lorazepam, similar to other benzodiazepines and

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psychological dependence. Because of its high potency, the smallest lorazepam tablet strength of 0.5 mg is also a significant dose. To minimise the risk of physical/psychological dependence, lorazepam is best used only short-term, at the smallest effective dose. If any benzodiazepine has been used long-term, the recommendation is a gradual dose taper over a period of weeks, months or longer, according to dose and duration of use, the degree of dependence and the individual.

1306: 1484:(FDA) pregnancy category D, which means it is likely to cause harm to the developing baby if taken during the first trimester of pregnancy. The evidence is inconclusive whether lorazepam if taken early in pregnancy results in reduced intelligence, neurodevelopmental problems, physical malformations in cardiac or facial structure, or other malformations in some newborns. Lorazepam given to pregnant women antenatally may cause 836: 1033: 57: 2021: 3053: 17435: 4909: 1938:, which, although rapidly absorbed orally or rectally, soon redistributes from the serum to other parts of the body, in particular, body fat. This explains why one lorazepam dose, despite its shorter serum half-life, has more prolonged peak effects than an equivalent diazepam dose. Lorazepam is rapidly conjugated at its 3-hydroxy group into lorazepam 1697:, panic attacks, short-term memory loss, and hyperthermia. It takes about 18–36 hours for the benzodiazepine to be removed from the body. The ease of physical dependence to lorazepam, (Ativan brand was particularly cited), and its withdrawal were brought to the attention of the British public during the early 1980s in Esther Rantzen's BBC TV series 1443:– This is a neurological clinical sign, consisting of unsteady and clumsy motion of the limbs and torso, due to the failure of gross muscle movement coordination, most evident on standing and walking. It is the classic way in which acute alcohol intoxication may affect a person. Benzodiazepines should not be administered to people already-ataxic. 1664:. The higher the dose and the longer the drug is taken, the greater the risk of experiencing unpleasant withdrawal symptoms. Withdrawal symptoms can, however, occur from standard dosages and also after short-term use. Benzodiazepine treatment should be discontinued as soon as possible via a slow and gradual dose reduction regimen. 1114:. It is given before a general anesthetic to reduce the amount of anesthetic required, or before unpleasant awake procedures, such as in dentistry or endoscopies, to reduce anxiety, to increase compliance, and to induce amnesia for the procedure. Lorazepam by mouth is given 90 to 120 minutes before procedures, and 1243:

Sedation is the side effect people taking lorazepam most frequently report. In a group of around 3,500 people treated for anxiety, the most common side effects complained of from lorazepam were sedation (15.9%), dizziness (6.9%), weakness (4.2%), and unsteadiness (3.4%). Side effects such as sedation

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Peak effects roughly coincide with peak serum levels, which occur 10 minutes after intravenous injection, up to 60 minutes after intramuscular injection, and 90 to 120 minutes after oral administration, but initial effects will be noted before this. A clinically relevant lorazepam dose will normally

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Children and the elderly – The safety and effectiveness of lorazepam is not well determined in children under 18 years of age, but it is used to treat acute seizures. Dose requirements have to be individualized, especially in people who are elderly and debilitated in whom the risk of oversedation is

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it is unclear whether cognitive impairments fully return to normal after stopping lorazepam use; cognitive deficits persist for at least six months after withdrawal, but longer than six months may be required for recovery of cognitive function. Lorazepam appears to have more profound adverse effects

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Lorazepam is highly protein bound and is extensively metabolized into pharmacologically inactive metabolites. Due to its poor lipid solubility, lorazepam is absorbed relatively slowly by mouth and is unsuitable for rectal administration. However, its poor lipid solubility and high degree of protein

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effects, benzodiazepines are generally not recommended for long-term use for the management of epilepsy. Increasing the dose may overcome tolerance, but tolerance may then develop to the higher dose and adverse effects may persist and worsen. The mechanism of tolerance to benzodiazepines is complex

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can also occur, such as worsening of seizures, or paradoxical excitement; paradoxical excitement is more likely to occur in the elderly, children, those with a history of alcohol abuse, and in people with a history of aggression or anger problems. Lorazepam's effects are dose-dependent, meaning the

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found sedative-hypnotics are the pharmaceuticals most frequently used outside of their prescribed medical purpose in the United States, with 35% of drug-related emergency department visits involving sedative-hypnotics. In this category, benzodiazepines are most commonly used. Males and females use

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and those with a psychiatric illness. Frustrating stimuli may trigger such reactions, though the drug may have been prescribed to help the person cope with such stress and frustration in the first place. As paradoxical effects appear to be dose-related, they usually subside on dose reduction or on

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Lorazepam serum levels are proportional to the dose administered. Giving 2 mg oral lorazepam will result in a peak total serum level of around 20 ng/mL around two hours later, half of which is lorazepam, half its inactive metabolite, lorazepam-glucuronide. A similar lorazepam dose given

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which is then excreted in the urine. Lorazepam glucuronide has no demonstrable CNS activity in animals. The plasma levels of lorazepam are proportional to the dose given. There is no evidence of accumulation of lorazepam on administration up to six months. On regular administration, diazepam will

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benzodiazepine, and its uniqueness, advantages, and disadvantages are largely explained by its pharmacokinetic properties (poor water and lipid solubility, high protein binding and anoxidative metabolism to a pharmacologically inactive glucuronide form) and by its high relative potency (lorazepam

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effects, but people soon develop tolerance to this with regular use. To avoid amnesia (or excess sedation) being a problem, the initial total daily lorazepam dose should not exceed 2 mg. This also applies to use for night sedation. Five participants in a sleep study were prescribed lorazepam

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Lorazepam may be quantitated in blood or plasma to confirm poisoning in hospitalized people, provide evidence of an impaired driving arrest or to assist in a medicolegal death investigation. Blood or plasma concentrations are usually in a range of 10–300 μg/L in persons either receiving the drug

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responses to cold stress. Symptoms of floppy infant syndrome and the neonatal benzodiazepine withdrawal syndrome have been reported to persist from hours to months after birth. Lorazepam may also inhibit fetal liver bilirubin glucuronidation, leading to neonatal jaundice. Lorazepam is present in

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Paradoxical effects: In some cases, paradoxical effects can occur with benzodiazepines, such as increased hostility, aggression, angry outbursts, and psychomotor agitation. These effects are seen more commonly with lorazepam than with other benzodiazepines. Paradoxical effects are more likely to

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People are ideally nursed in a kind, frustration-free environment, since, when given or taken in high doses, benzodiazepines are more likely to cause paradoxical reactions. If shown sympathy, even quite crudely feigned, people may respond solicitously, but they may respond with disproportionate

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of violent or agitated individuals, but haloperidol plus promethazine is preferred due to better effectiveness and due to lorazepam's adverse effects on respiratory function. However, adverse effects such as behavioral disinhibition may make benzodiazepines inappropriate for some people who are

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be effective for six to 12 hours, making it unsuitable for regular once-daily administration, so it is usually prescribed as two to four daily doses when taken regularly, but this may be extended to five or six, especially in the case of elderly people who could not handle large doses at once.

1677:. The risk and severity of withdrawal are increased with long-term use, use of high doses, abrupt or over-rapid reduction, among other factors. Short-acting benzodiazepines such as lorazepam are more likely to cause a more severe withdrawal syndrome compared to longer-acting benzodiazepines. 1630:

The likelihood of dependence is relatively high with lorazepam compared to other benzodiazepines. Lorazepam's relatively short serum half-life, its confinement mainly to blood, and its inactive metabolite can result in interdose withdrawal phenomena and next-dose cravings, that may reinforce

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The magnitude and duration of lorazepam effects are dose-related, meaning larger doses have stronger and longer-lasting effects, because the brain has spare benzodiazepine drug receptor capacity, with single, clinical doses leading only to an occupancy of some 3% of the available receptors.

2099:. Toxicity from propylene glycol has been reported in the case of a person receiving a continuous lorazepam infusion. Intravenous injections should be given slowly and they should be closely monitored for side effects, such as respiratory depression, hypotension, or loss of airway control. 1273:

4 mg at night, and the next evening, three subjects unexpectedly volunteered memory gaps for parts of that day, an effect that subsided completely after two to three days' use. Amnesic effects cannot be estimated from the degree of sedation present, since the two effects are unrelated.

1528:, causes impairments in body balance and standing steadiness in individuals who wake up at night or the next morning. Falls and hip fractures are frequently reported. The combination with alcohol increases these impairments. Partial, but incomplete, tolerance develops to these impairments. 1240:

higher the dose, the stronger the effects (and side effects) will be. Using the smallest dose needed to achieve desired effects lessens the risk of adverse effects. Sedative drugs and sleeping pills, including lorazepam, have been associated with an increased risk of death.

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to their anti-seizure effects, benzodiazepines such as lorazepam are not considered first-line therapies. Additionally, common seizure characteristics (hypersalivation, jaw-clenching, involuntary swallowing, etc.) pose some difficulties with regard to oral administration.

1091:. In this setting, impaired liver function is not a hazard with lorazepam, since lorazepam does not require oxidation, in the liver or otherwise, for its metabolism. Lorazepam is noted as being the most tolerable benzodiazepine in those with advanced-stage liver disease. 2770:

Papini O, da Cunha SP, da Silva Mathes Ado C, Bertucci C, Moisés EC, de Barros Duarte L, et al. (2006). "Kinetic disposition of lorazepam with a focus on the glucuronidation capacity, transplacental transfer in parturients and racemization in biological samples".

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In cases of a suspected lorazepam overdose, it is important to establish whether the person is a regular user of lorazepam or other benzodiazepines since regular use causes tolerance to develop. Also, one must ascertain whether other substances were also ingested.

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increase its rate of metabolism. Some antidepressants, antiepileptic drugs such as phenobarbital, phenytoin and carbamazepine, sedative antihistamines, opiates, antipsychotics and alcohol, when taken with lorazepam may result in enhanced sedative effects.

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and a period of stabilization on this, and only then initiating dose reductions. The advantage of switching to diazepam is that dose reductions are felt less acutely, because of the longer half-lives (20–200 hours) of diazepam and its active metabolites.

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Pure lorazepam is an almost white powder that is nearly insoluble in water and oil. In medicinal form, it is mainly available as tablets and a solution for injection, but, in some locations, it is also available as a skin patch, an oral solution, and a

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In general, benzodiazepines should be prescribed for short periods only (e.g. 2–4 weeks). Extension of the treatment period should not take place without reevaluation of the need for continued therapy. Continuous long-term use of product is not

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Lorazepam is used in the short-term management of severe anxiety. In the US, the FDA advises against use of benzodiazepines such as lorazepam for longer than four weeks. It is fast acting, and useful in treating fast onset panic anxiety.

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Papini O, Bertucci C, da Cunha SP, dos Santos NA, Lanchote VL (2006). "Quantitative assay of lorazepam and its metabolite glucuronide by reverse-phase liquid chromatography-tandem mass spectrometry in human plasma and urine samples".

1546:, it does not require liver oxidation, but only liver glucuronidation into lorazepam-glucuronide. Therefore, impaired liver function is unlikely to result in lorazepam accumulation to an extent causing adverse reactions. Similarly 1680:

Withdrawal symptoms can occur after taking therapeutic doses of lorazepam for as little as one week. Withdrawal symptoms include headaches, anxiety, tension, depression, insomnia, restlessness, confusion, irritability, sweating,

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effects of both drugs, with potentially embarrassing or criminal consequences. Some experts advise that people should be warned against drinking alcohol while on lorazepam treatment, but such clear warnings are not universal.

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Dependence typified by a withdrawal syndrome occurs in about one-third of individuals who are treated for longer than four weeks with a benzodiazepine. Higher doses and longer periods of use increase the risk of developing a

1419:– Benzodiazepines, including lorazepam, may depress central nervous system respiratory drive and are contraindicated in severe respiratory failure. An example would be the inappropriate use to relieve anxiety associated with 2212:, benzodiazepines are the most commonly used pharmaceutical drugs, with 26% of attempted suicides involving them. Lorazepam was the third-most-common benzodiazepine used outside of prescription in these ER visit statistics. 1647:

On abrupt or overly rapid discontinuation of lorazepam, anxiety, and signs of physical withdrawal have been observed, similar to those seen on withdrawal from alcohol and barbiturates. Lorazepam, as with other

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often resemble the condition being treated, but typically at a more intense level and may be difficult to diagnose. Withdrawal symptoms can range from mild anxiety and insomnia to more severe symptoms such as

1231:. In the elderly, falls may occur as a result of benzodiazepines. Adverse effects are more common in the elderly, and they appear at lower doses than in younger people. Benzodiazepines can cause or worsen 1178:

with inability to speak is responsive to lorazepam. Symptoms may recur and treatment for some days may be necessary. Catatonia due to abrupt or overly rapid withdrawal from benzodiazepines, as part of the

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Greenblatt DJ, Schillings RT, Kyriakopoulos AA, Shader RI, Sisenwine SF, Knowles JA, et al. (1976). "Clinical pharmacokinetics of lorazepam. I. Absorption and disposition of oral 14C-lorazepam".

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has been found to be superior to lorazepam both in effectiveness and overall cost; as a result, the use of propofol for this indication is now encouraged, whereas the use of lorazepam is discouraged.

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Greenblatt DJ, Shader RI, Franke K, Maclaughlin DS, Harmatz JS, Allen MD, et al. (1991). "Pharmacokinetics and bioavailability of intravenous, intramuscular, and oral lorazepam in humans".

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be updated for all benzodiazepine medicines to describe the risks of abuse, misuse, addiction, physical dependence, and withdrawal reactions consistently across all the medicines in the class.

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Pietras CJ, Lieving LM, Cherek DR, Lane SD, Tcheremissine OV, Nouvion S (2005). "Acute effects of lorazepam on laboratory measures of aggressive and escape responses of adult male parolees".

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Many beneficial effects of lorazepam (e.g., sedative, muscle relaxant, anti-anxiety, and amnesic effects) may become adverse effects when unwanted. Adverse effects can include sedation and

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Greenblatt DJ, von Moltke LL, Ehrenberg BL, Harmatz JS, Corbett KE, Wallace DW, et al. (2000). "Kinetics and dynamics of lorazepam during and after continuous intravenous infusion".

291: 3051:, Stanley C. Bell, "5-monocyclic aryl-1, 3-dihydro-2h-1, 4-benzodiazepin-2-ones", published 1967-01-03, issued 1967-01-03, assigned to American Home Products 6368: 1865:

therapeutically or in those arrested for impaired driving. Approximately 300–1000 μg/L is found in people after acute overdosage. Lorazepam may not be detected by commonly used

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McLean MJ, Macdonald RL (1988). "Benzodiazepines, but not beta-carbolines, limit high frequency repetitive firing of action potentials of spinal cord neurons in cell culture".

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Bishop KI, Curran HV (September 1995). "Psychopharmacological analysis of implicit and explicit memory: a study with lorazepam and the benzodiazepine antagonist flumazenil".

1464:– Sleep apnea may be worsened by lorazepam's central nervous system depressant effects. It may further reduce the person's ability to protect his or her airway during sleep. 13039: 11728: 1711:

Lorazepam is not usually fatal in overdose, but may cause respiratory depression if taken in overdose with alcohol. The combination also causes greater enhancement of the

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If regular treatment is continued for longer than four to six months, dose increases may be necessary to maintain effects, but treatment-resistant symptoms may in fact be

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Lorazepam can effectively reduce agitation and induce sleep, and the duration of effects from a single dose makes it an appropriate choice for the short-term treatment of

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Bieniek SA, Ownby RL, Penalver A, Dominguez RA (1998). "A double-blind study of lorazepam versus the combination of haloperidol and lorazepam in managing agitation".

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Kalachnik JE, Hanzel TE, Sevenich R, Harder SR (2002). "Benzodiazepine behavioral side effects: review and implications for individuals with mental retardation".

2450:[Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). 16129: 15974: 10650: 327: 17500: 14925: 1167:, it is preferably given together with haloperidol. Lorazepam is absorbed relatively slowly if given intramuscularly, a common route in restraint situations. 13029: 13014: 4843:

Riker RR, Fraser GL (2005). "Adverse events associated with sedatives, analgesics, and other drugs that provide patient comfort in the intensive care unit".

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rather than benzodiazepine receptors. Sustained repetitive firing seems to get limited, by the benzodiazepine effect of slowing recovery of sodium channels

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Griffiths RR, Johnson MW (2005). "Relative abuse liability of hypnotic drugs: a conceptual framework and algorithm for differentiating among compounds".

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Authier N, Balayssac D, Sautereau M, Zangarelli A, County P, Somogyi AA, et al. (2009). "Benzodiazepine dependence: focus on withdrawal syndrome".

818: 14920: 304: 14329: 14063: 13024: 9174: 4313:

Bishop KI, Curran HV (December 1998). "An investigation of the effects of benzodiazepine receptor ligands and of scopolamine on conceptual priming".

3526:"Benzodiazepines in the Management of Seizures and Status Epilepticus: A Review of Routes of Delivery, Pharmacokinetics, Efficacy, and Tolerability" 14806: 14516: 14456: 14361: 14231: 11883: 11721: 9984: 2431: 1826:, and not as an activator per se. Lorazepam and similar medications do however act in synergy with alcohol, which increases the risk of overdose. 1969:, which may also explain its marked amnesic effects. Its main pharmacological effects are the enhancement of the effects of the neurotransmitter 1841:. Otherwise, management is by observation, including of vital signs, support and, only if necessary, considering the hazards of doing so, giving 1110:

Its relative effectiveness in preventing new memory formation, along with its ability to reduce agitation and anxiety, makes lorazepam useful as

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van Dalfsen AN, van den Eede F, van den Bossche B, Sabbe BG (2006). "(title in Dutch)" [Benzodiazepines in the treatment of catatonia].

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Kanto JH (1982). "Use of benzodiazepines during pregnancy, labour and lactation, with particular reference to pharmacokinetic considerations".

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for benzodiazepines. This is due to the fact that the majority of these screening tests are only able to detect benzodiazepines that undergo

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Herman RJ, Van Pham JD, Szakacs CB (1989). "Disposition of lorazepam in human beings: enterohepatic recirculation and first-pass effect".

1591: 16999: 16121: 16101: 16086: 16056: 15474: 15384: 14816: 14721: 14711: 14691: 14671: 14651: 14280: 13102: 11759: 11714: 9645: 2389: 2358: 2320: 922:(injection into a muscle.) When given by injection, onset of effects is between one and thirty minutes and effects last for up to a day. 6562: 5780: 3034: 17035: 16792: 16787: 16772: 16076: 14990: 14773: 14301: 13987: 13982: 13532: 13266: 13261: 13256: 13246: 13097: 9635: 1413:– Past hypersensitivity or allergy to lorazepam, to any benzodiazepine, or to any of the ingredients in lorazepam tablets or injections 6386: 2000:

The anticonvulsant properties of lorazepam and other benzodiazepines may be, in part or entirely, due to binding to voltage-dependent

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in the treatment of status epilepticus and has a lower risk of continuing seizures that might require additional medication. However,

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Isojärvi JI, Tokola RA (December 1998). "Benzodiazepines in the treatment of epilepsy in people with intellectual disability".

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receptors; which results in the therapeutic actions of benzodiazepines. They, however, do not on their own activate the GABA

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Cock HR, Schapira AH (2002). "A comparison of lorazepam and diazepam as initial therapy in convulsive status epilepticus".

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Scharf MB, Kales A, Bixler EO, Jacoby JA, Schweitzer PK (1982). "Lorazepam-efficacy, side-effects, and rebound phenomena".

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Scharf MB, Kales A, Bixler EO, Jacoby JA, Schweitzer PK (1982). "Lorazepam-efficacy, side effects, and rebound phenomena".

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in Canada. In the United Kingdom, it is a Class C, Schedule 4 Controlled Drug under the Misuse of Drugs Regulations 2001.

1437:, narcotics, or other psychoactive substances. It should, therefore, not be administered to a drunk or intoxicated person. 1244:

and unsteadiness increased with age. Cognitive impairment, behavioral disinhibition and respiratory depression as well as

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Sorel L, Mechler L, Harmant J (1981). "Comparative trial of intravenous lorazepam and clonazepam im status epilepticus".

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1987 advertisement. "In a world where certainties are few...no wonder Ativan is prescribed by so many caring clinicians."

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Mets MA, Volkerts ER, Olivier B, Verster JC (2010). "Effect of hypnotic drugs on body balance and standing steadiness".

1423:. The anxiolytic effects may also be detrimental to a person's willingness and ability to fight for breath. However, if 1370: 17475: 17082: 14387: 5327: 2443: 1661: 1493: 1180: 974: 6592: 6321:

Yaucher NE, Fish JT, Smith HW, Wells JA (2003). "Propylene glycol-associated renal toxicity from lorazepam infusion".

6229:"Iomazenil SPECT imaging demonstrates significant benzodiazepine receptor reserve in human and nonhuman primate brain" 1488:

in the neonate, or respiratory depression necessitating ventilation. Regular lorazepam use during late pregnancy (the

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may occur. Older people more often develop adverse effects. In this age group, lorazepam is associated with falls and

17510: 17470: 14325: 13756: 11574: 10784: 9901: 5749: 5491: 1470:– This condition is characterized by muscle weakness, so a muscle relaxant such as lorazepam may exacerbate symptoms. 1389: 1211: 825: 794: 147: 3397:

Treiman DM, Walker MC (2006). "Treatment of seizure emergencies: convulsive and non-convulsive status epilepticus".

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has limited value here, as the person is unlikely to recall this later, owing to drug-induced anterograde amnesia.

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Coming off long-term lorazepam use may be more realistically achieved by a gradual switch to an equivalent dose of

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use, wherein it is taken to achieve a high, or when the medication is continued long-term against medical advice.

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in 1977 under the brand names Ativan and Temesta. The drug was developed by D.J. Richards, president of research.

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accumulate, since it has a longer half-life and active metabolites, these metabolites also have long half-lives.

1349: 455: 276: 128: 4600: 3713:"An Economic Evaluation of Propofol and Lorazepam for Critically Ill Patients Undergoing Mechanical Ventilation" 1993:

GABA to be present. Thus, the effect of benzodiazepines is to enhance the effects of the neurotransmitter GABA.

8555: 4753:"Specific effects of an amnesic drug: effect of lorazepam on study time allocation and on judgment of learning" 2432:

https://www.tga.gov.au/resources/prescription-medicines-registrations/lorazepam-aft-aft-pharmaceuticals-pty-ltd

2009: 1327: 1071:, but induce prolonged sedation. Oral benzodiazepines, including lorazepam, are occasionally used as long-term 8321: 2899:

Riss J, Cloyd J, Gates J, Collins S (2008). "Benzodiazepines in epilepsy: pharmacology and pharmacokinetics".

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Braestrup C, Squires RF (1978). "Pharmacological characterization of benzodiazepine receptors in the brain".

5686: 2448:"RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" 3925:

Verhagen EH, Hesselmann GM, Besse TC, de Graeff A (2005). "(title in Dutch)" [Palliative sedation].

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Baciewicz AM, Chrisman CR, Finch CK, Self TH (2008). "Update on rifampin and rifabutin drug interactions".

4892: 2990: 2451: 2209: 1481: 1356: 1285: 1198:, i.e. nausea and vomiting caused or worsened by psychological sensitization to the thought of being sick. 1017:, especially in the presence of severe anxiety or night terrors. It has a fairly short duration of action. 680: 561: 5234:

MacKinnon GL, Parker WA (1982). "Benzodiazepine withdrawal syndrome: a literature review and evaluation".

3639:"EFNS guideline on the diagnosis and management of alcohol-related seizures: report of an EFNS task force" 802:

InChI=1S/C15H10Cl2N2O2/c16-8-5-6-12-10(7-8)13(19-15(21)14(20)18-12)9-3-1-2-4-11(9)17/h1-7,15,21H,(H,18,20)

17389: 14045: 13156: 10672: 10322: 8875: 7973: 5687: 3957:

Arcangeli A, Antonelli M, Mignani V, Sandroni C (2005). "Sedation in PACU: the role of benzodiazepines".

2404:"FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)" 2036:

Lorazepam tablets and syrups are administered orally. Lorazepam tablets of the Ativan brand also contain

1088: 879: 641: 4274:"ESMO Minimum Clinical Recommendations for prophylaxis of chemotherapy-induced nausea and vomiting (NV)" 1087:

Lorazepam's anticonvulsant and CNS depressant properties are useful for the treatment and prevention of

17425: 13166: 10427: 10241: 5695: 1323: 3843:"The effect of intravenous premedication with lorazepam (Ativan), pentobarbital or diazepam on recall" 1338: 630: 425: 17375: 16949: 16272: 16170: 15854: 15366: 11222: 10078: 8860: 8474: 5657: 3794:"A randomized, double-blind, placebo-controlled study of lorazepam as premedication for bronchoscopy" 3067: 2403: 2221: 2030: 2005: 1934:

compartment, causing relatively prolonged peak effects. This contrasts with the highly lipid-soluble

1853: 1616: 1576: 1232: 992:. In 2022, it was the 80th most commonly prescribed medication in the United States, with more than 8 984:

Lorazepam was initially patented in 1963 and went on sale in the United States in 1977. It is on the

954: 13181: 13176: 13171: 1118:

lorazepam as late as 10 minutes before procedures. Lorazepam is sometimes used as an alternative to

17465: 17277: 17195: 17096: 17013: 16882: 16305: 16202: 16034: 15803: 13738: 13734: 12907: 10906: 10404: 10218: 8283: 7776: 6694: 4501:

Bond A, Lader M (1988). "Differential effects of oxazepam and lorazepam on aggressive responding".

2249: 970: 657: 6563:"Drug Abuse Warning Network, 2006: National Estimates of Drug-Related Emergency Department Visits" 6513: 981:. Due to these concerns, lorazepam use is generally only recommended for up to two to four weeks. 17223: 17159: 16495: 14401: 11622: 11334: 11178: 10813: 9123: 8430: 8192: 8150: 8029: 7619: 7493: 5806:

Funderburk FR, Griffiths RR, McLeod DR, Bigelow GE, Mackenzie A, Liebson IA, et al. (1988).

3637:

Bråthen G, Ben-Menachem E, Brodtkorb E, Galvin R, Garcia-Monco JC, Halasz P, et al. (2005).

3524:

Kienitz R, Kay L, Beuchat I, Gelhard S, von Brauchitsch S, Mann C, et al. (September 2022).

3151: 2076: 1970: 1769: 1316: 899: 208: 78: 17: 5808:"Relative abuse liability of lorazepam and diazepam: an evaluation in 'recreational' drug users" 5269: 3449: 3441: 17027: 16963: 16354: 15320: 15311: 14875: 14862: 14844: 14786: 14410: 11923: 10537: 10476: 10290: 9250: 8059: 7229: 6807: 3882:

Tsui BC, Wagner A, Finucane B (2004). "Regional anaesthesia in the elderly: a clinical guide".

3216:(3rd ed.). Philadelphia: Wolters Kluwer Health/Lippincott Williams & Wilkins. p. 2256:

by 3200% in 1998 after having obtained exclusive licensing agreements for certain ingredients.

1657: 1430: 1424: 1100: 895: 6570: 5508: 5481: 4630:

Michel L, Lang JP (2003). "(title in French)" [Benzodiazepines and forensic aspects].

4038:

Zoupanos BN, Bryois C (July 2005). "" [Treatment of agitation in the emergency room].

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Suicidality: Benzodiazepines are associated with increased risk of suicide, possibly due to

1056:

has a superior success rate compared to lorazepam and other drugs, at least in the elderly.

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LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]

2378:(4 ed.). Philadelphia: Wolters Kluwer/Lippincott Williams & Wilkins. p. 106. 2200: 1918: 1823: 1783: 1254: 1236: 1164: 570: 412: 184: 13140: 5004:

McElhatton PR (1994). "The effects of benzodiazepine use during pregnancy and lactation".

3592:"Benzodiazepines for alcohol withdrawal in the elderly and in patients with liver disease" 2478:"Lorazepam Macure 4mg/ml solution for injection Summary of Product Characteristics (SmPC)" 1218:, inhibiting the formation of new memories, pupil constriction and hangover effects. With 550: 8: 17236: 15374: 14778: 14176: 14059: 13186: 13112: 12201: 12043: 11751: 11577: 11460: 11083: 10800: 10093: 10088: 9655: 9212: 7852: 7527: 6736: 6680: 5783:. New Zealand Medicines and Medical Devices Safety Authority. 4 June 1999. Archived from 3824: 3711:

Cox CE, Reed SD, Govert JA, Rodgers JE, Campbell-Bright S, Kress JP, et al. (2008).

3692:. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases. 2012. 2806: 2088: 2080: 2061: 1842: 1716: 1653: 1450:– Lorazepam has pupil-dilating effects, which may further interfere with the drainage of 1420: 1416: 1269: 1183:, should also respond to lorazepam treatment. As lorazepam can have paradoxical effects, 1127: 1123: 1115: 966: 942: 938: 907: 887: 485: 476: 215: 6402:

Smith TJ, Ritter JK, Poklis JL, Fletcher D, Coyne PJ, Dodson P, et al. (May 2012).

6185: 6170:"Benzodiazepine receptors mediate regional blood flow changes in the living human brain" 5017: 4721: 1981:

receptor via increasing the frequency of opening of the chloride ion channel on the GABA

1723:

Greater adverse effects may also occur when lorazepam is used with other drugs, such as

953:. When given intravenously, the person should be closely monitored. Among those who are 684: 661: 15646: 15641: 15544: 15251: 15021: 14153: 13816: 13714: 13371: 13004: 12376: 11978: 10524: 9954: 9870: 9235: 6843: 6650: 6437:

Weschules DJ (December 2005). "Tolerability of the compound ABHR in hospice patients".

6346: 6258: 6150: 6071: 5981: 5924: 5899: 5876: 5633: 5608: 5423: 5374: 5112: 4986: 4868: 4825: 4782: 4733: 4686: 4569: 4557: 4526: 4430: 4381: 4338: 4192: 4180: 4091: 4066: 4020: 3907: 3737: 3712: 3668: 3619: 3607: 3550: 3525: 3479: 3422: 3374: 3349: 3325: 3300: 3278: 3156: 2924: 2752: 2106: 2049: 1950: 1931: 1818:. However, fatal overdoses on benzodiazepines alone are rare and less common than with 1525: 1363: 1068: 1045: 875: 158: 6420: 6403: 3457: 2503: 2477: 17295: 16906: 16580: 16224: 16096: 15343: 15236: 14370: 14296: 14067: 14010: 13951: 13719: 13291: 12386: 12163: 12158: 11706: 11511: 10981: 10976: 10886: 9917: 9875: 9708: 9383: 9378: 8629: 8133: 8048: 7997: 7943: 7532: 6853: 6544: 6491: 6487: 6454: 6425: 6338: 6285: 6250: 6245: 6228: 6209: 6204: 6169: 6142: 6107: 6063: 6023: 5973: 5929: 5868: 5829: 5824: 5807: 5701: 5669: 5638: 5589: 5543: 5514: 5487: 5445: 5415: 5366: 5251: 5189: 5158: 5148: 5104: 5100: 5069: 5029: 5025: 4978: 4974: 4943: 4939: 4860: 4856: 4817: 4774: 4725: 4678: 4639: 4612: 4604: 4561: 4518: 4483: 4422: 4373: 4330: 4295: 4254: 4227: 4223: 4184: 4146: 4096: 4047: 4012: 4008: 3974: 3934: 3899: 3895: 3864: 3816: 3742: 3693: 3660: 3655: 3638: 3611: 3555: 3506: 3471: 3461: 3414: 3410: 3379: 3330: 3270: 3231: 3221: 3192: 3024: 2962: 2916: 2912: 2862: 2788: 2744: 2740: 2709: 2379: 2348: 2310: 2193: 1977:

receptor. Benzodiazepines, such as lorazepam, enhance the effects of GABA at the GABA

1670: 1467: 871: 340: 120: 6627: 6350: 6262: 6075: 5985: 5880: 5378: 4990: 4872: 4786: 4737: 4690: 4573: 4530: 4385: 4342: 4196: 3911: 3672: 3483: 3426: 2928: 2756: 17505: 17490: 17073: 16570: 16485: 16285: 16004: 15793: 15131: 13972: 13638: 13125: 12902: 12872: 12804: 12711: 12381: 12261: 12153: 11865: 11855: 11506: 11501: 11251: 10058: 9668: 8594: 8103: 7132: 6848: 6762: 6483: 6446: 6415: 6330: 6240: 6199: 6189: 6154: 6134: 6099: 6055: 6015: 5963: 5919: 5911: 5860: 5819: 5628: 5620: 5581: 5427: 5405: 5358: 5243: 5140: 5116: 5096: 5061: 5021: 4970: 4935: 4852: 4809: 4764: 4717: 4670: 4659:"Paradoxical reactions to benzodiazepines: literature review and treatment options" 4596: 4553: 4510: 4434: 4412: 4365: 4322: 4285: 4219: 4176: 4136: 4131: 4126: 4118: 4086: 4082: 4078: 4004: 3966: 3891: 3854: 3808: 3732: 3724: 3650: 3623: 3603: 3545: 3537: 3453: 3406: 3369: 3365: 3361: 3320: 3312: 3262: 3184: 3075: 2954: 2908: 2852: 2780: 2736: 2701: 2109:

of lorazepam, while sometimes used as treatment for nausea especially in people in

2092: 2065: 1990: 1838: 1410: 1277: 1064: 859: 697: 369: 259: 6334: 4829: 4674: 4024: 3282: 3095: 2133:

Historically, lorazepam is one of the "classical" benzodiazepines. Others include

1965:

Relative to other benzodiazepines, lorazepam is thought to have high affinity for

17439: 17325: 17320: 17290: 17119: 17114: 16717: 16682: 16672: 16637: 16244: 16219: 15686: 15379: 15261: 14416: 14378: 14264: 14129: 14113: 14101: 14055: 14006: 13821: 13796: 13791: 13605: 13338: 13191: 11993: 11988: 11850: 11783: 11596: 11582: 11549: 11449: 10691: 10643: 10557: 10379: 10344: 10143: 10021: 9939: 9934: 9912: 9794: 9303: 8993: 8985: 8975: 8772: 8503: 7465: 6593:"List of psychotropic substances under international control: Green List 23rd ed" 6377: 6373: 6309: 5658:"Issues in the clinical use of benzodiazepines: potency, withdrawal, and rebound" 5624: 5483:

The Clinical Toxicology Laboratory: Contemporary Practice of Poisoning Evaluation

5362: 5144: 5065: 4452: 3728: 3211: 3125: 2662: 1905: 1822:. Such a difference is largely due to benzodiazepine activity as a neuroreceptor 1811: 1699: 1624: 1562: 1489: 1228: 1224: 1076: 950: 919: 510: 402: 395: 387: 377: 106: 65: 10804: 9191: 8494: 5864: 5178:"Addiction: Part I. Benzodiazepines – side effects, abuse risk and alternatives" 3687: 2273: 17300: 17256: 16847: 16747: 16657: 16331: 16187: 16130: 15975: 15931: 15886: 15631: 15621: 15241: 15161: 14758: 14661: 14276: 14105: 14014: 13881: 13876: 13300: 12188: 12093: 11968: 11933: 11928: 11814: 11779: 11675: 11544: 11491: 11476: 11385: 11184: 10991: 10871: 10866: 10463: 10391: 10277: 10188: 10138: 10082: 10053: 10042: 10026: 9922: 9403: 9348: 9245: 9230: 9200: 9129: 8965: 8807: 8721: 8569: 8543: 8436: 8211: 7947: 7887: 7821: 7799: 7754: 6717: 6363: 6103: 5848: 5585: 5535: 3970: 3541: 2958: 2784: 2252:(FTC) that they had raised the price of generic lorazepam by 2600% and generic 2096: 2069: 2053: 2001: 1901: 1834: 1665: 1649: 1600: 1595: 1579:. Potent benzodiazepines with a relatively short half life, such as lorazepam, 1535: 1434: 1276:

High-dose or prolonged parenterally-administered lorazepam with its associated

1080: 1060: 1021: 962: 851: 239: 14791: 14386: 5247: 5087:

Butler JM, Begg EJ (2008). "Free drug metabolic clearance in elderly people".

4417: 4400: 3188: 2199:

A 2006 large-scale, nationwide, US government study of pharmaceutical-related

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Rosebush PI, Mazurek MF (1996). "Catatonia after benzodiazepine withdrawal".

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benzodiazepines for nonmedical purposes equally. Of drugs used in attempted

17182: 16930: 16842: 16832: 16742: 16677: 16575: 16505: 16440: 16430: 16385: 16009: 15994: 15941: 15896: 15751: 15706: 15691: 15681: 15666: 15606: 15246: 15226: 15166: 14716: 14571: 14431: 14144: 13886: 13836: 13806: 13751: 13709: 13704: 13699: 13689: 13684: 13613: 13271: 13236: 13231: 13201: 13150: 13077: 12769: 12759: 12531: 12526: 12516: 12511: 12441: 12266: 12256: 12148: 12108: 12073: 12053: 12038: 12023: 11958: 11953: 11938: 11908: 11903: 11888: 11834: 11824: 11564: 11496: 11415: 11330: 11242: 11134: 11116: 11067: 10961: 10956: 10826: 10758: 10660: 10655: 10565: 10468: 10419: 10354: 10282: 10233: 10178: 10173: 9979: 9896: 9865: 9860: 9855: 9845: 9840: 9802: 9698: 9688: 9620: 9534: 9476: 9461: 9363: 9323: 9313: 9293: 9288: 9278: 9268: 9044: 9034: 9024: 9003: 8926: 8869: 8824: 8711: 8533: 8392: 8372: 8236: 8226: 8078: 7842: 7803: 7517: 6960: 6955: 6945: 6934: 6883: 6757: 6603: 6548: 6458: 6429: 6342: 6194: 6111: 6027: 5977: 5933: 5872: 5673: 5642: 5593: 5547: 5469:(8th ed.). Foster City, CA: Biomedical Publications. pp. 860–862. 5419: 5370: 5193: 5162: 5108: 5073: 4864: 4778: 4769: 4752: 4682: 4643: 4616: 4565: 4426: 4299: 4258: 4244: 4150: 4100: 4051: 4016: 3978: 3938: 3903: 3746: 3697: 3664: 3559: 3510: 3475: 3418: 3383: 3334: 3072:

World Health Organization model list of essential medicines: 21st list 2019

2966: 2920: 2866: 2792: 2748: 2705: 1191: 989: 978: 467:)-7-Chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-1,4-benzodiazepin-2-one 254: 35: 6289: 6254: 6213: 6146: 6138: 6059: 5833: 5745: 5255: 5139:. Handbook of Experimental Pharmacology. Vol. 182. pp. 335–360. 5033: 4982: 4947: 4821: 4522: 4487: 4377: 4334: 4326: 4231: 4188: 3859: 3842: 3820: 3615: 3274: 3196: 48: 16981: 16935: 16812: 16807: 16802: 16727: 16712: 16707: 16662: 16641: 16633: 16545: 16540: 16525: 16510: 16445: 16390: 15966: 15956: 15951: 15946: 15926: 15911: 15901: 15881: 15783: 15766: 15756: 15746: 15736: 15731: 15701: 15676: 15671: 15651: 15636: 15601: 15586: 15549: 15484: 15444: 15434: 15291: 15286: 15271: 15256: 15196: 15061: 14965: 14960: 14955: 14945: 14940: 14821: 14768: 14763: 14748: 14591: 14566: 14556: 14546: 14536: 14526: 14441: 14436: 14426: 14339: 14226: 14221: 14191: 14171: 13926: 13906: 13856: 13679: 13661: 13656: 13646: 13623: 13618: 13585: 13507: 13348: 13315: 13305: 13161: 13145: 13049: 12932: 12849: 12829: 12819: 12789: 12754: 12706: 12696: 12656: 12651: 12626: 12611: 12571: 12561: 12496: 12466: 12416: 12361: 12336: 12316: 12311: 12276: 12173: 12128: 12083: 12063: 12028: 12003: 11898: 11875: 11799: 11769: 11670: 11612: 11607: 11601: 11554: 11486: 11481: 11426: 11405: 11400: 11390: 11355: 11325: 11315: 11300: 11280: 11047: 11042: 11014: 10951: 10943: 10928: 10881: 10743: 10687: 10682: 10638: 10612: 10570: 10547: 10532: 10491: 10437: 10305: 10251: 10201: 10168: 10153: 10113: 9974: 9969: 9964: 9835: 9817: 9807: 9736: 9716: 9678: 9554: 9491: 9486: 9431: 9416: 9388: 9353: 9338: 9273: 9260: 9225: 9054: 9039: 9029: 9007: 8949: 8906: 8884: 8705: 8691: 8639: 8614: 8609: 8382: 8377: 8263: 8221: 8167: 8138: 8113: 8108: 8083: 7963: 7958: 7922: 7902: 7847: 7837: 7742: 7716: 7609: 7593: 7552: 7478: 7445: 7389: 7307: 7199: 7178: 7127: 7038: 7028: 6998: 6988: 6983: 6868: 6833: 6797: 6787: 6772: 6495: 5394:"How theories evolved concerning the mechanism of action of barbiturates" 4813: 3868: 3266: 2857: 2841:"Prescribed Benzodiazepines and Suicide Risk: A Review of the Literature" 2840: 2769: 2504:"Lorazepam Aristo 1 mg tablets Summary of Product Characteristics (SmPC)" 2253: 2158: 1939: 1873: 1819: 1799: 1744: 1694: 1559: 1461: 1245: 1207: 1184: 1151: 946: 911: 227: 223: 114: 14291: 7768: 5968: 5849:"Strategies for optimizing antiepileptic drug therapy in elderly people" 5301: 5212: 4729: 3770: 3080: 2713: 1268:

Amnesic effects: Among benzodiazepines, lorazepam has relatively strong

530: 17285: 17213: 17208: 17144: 17139: 17129: 17124: 17104: 16925: 16914: 16910: 16877: 16762: 16757: 16732: 16722: 16697: 16692: 16687: 16628: 16618: 16600: 16595: 16565: 16555: 16515: 16480: 16435: 16425: 16420: 16415: 16400: 16365: 16290: 16234: 16211: 16179: 16106: 16066: 16024: 16014: 15989: 15961: 15921: 15906: 15826: 15821: 15761: 15741: 15726: 15716: 15581: 15571: 15499: 15494: 15489: 15479: 15439: 15394: 15389: 15301: 15281: 15221: 15211: 15141: 15121: 15106: 15096: 15086: 15071: 15056: 15046: 15036: 15026: 14985: 14980: 14975: 14950: 14930: 14910: 14836: 14826: 14811: 14801: 14753: 14701: 14636: 14561: 14551: 14541: 14521: 14496: 14491: 14471: 14451: 14421: 14259: 14211: 14206: 14124: 14119: 14025: 13996: 13992: 13901: 13866: 13811: 13801: 13761: 13694: 13522: 13487: 13452: 13447: 13401: 13391: 13320: 13281: 13241: 13226: 13206: 13196: 13135: 13130: 13120: 13087: 13069: 12965: 12912: 12877: 12824: 12814: 12784: 12779: 12716: 12691: 12646: 12621: 12601: 12581: 12576: 12566: 12546: 12501: 12491: 12476: 12436: 12431: 12401: 12356: 12351: 12331: 12321: 12301: 12296: 12286: 12246: 12241: 12236: 12231: 12226: 12216: 12211: 12206: 12178: 12033: 11948: 11943: 11829: 11819: 11794: 11654: 11649: 11644: 11634: 11435: 11395: 11360: 11350: 11345: 11340: 11320: 11305: 11295: 11275: 11238: 11155: 11129: 11124: 11106: 11091: 11073: 11057: 10861: 10831: 10821: 10738: 10711: 10701: 10622: 10602: 10575: 10510: 10486: 10481: 10364: 10359: 10349: 10339: 10300: 10295: 10206: 10148: 10133: 9944: 9850: 9746: 9726: 9693: 9683: 9673: 9663: 9630: 9612: 9597: 9544: 9539: 9501: 9496: 9471: 9456: 9426: 9421: 9411: 9393: 9069: 8997: 8944: 8921: 8916: 8899: 8839: 8797: 8782: 8664: 8619: 8604: 8584: 8579: 8574: 8490: 8407: 8397: 8387: 8346: 8341: 8291: 8273: 8268: 8251: 8246: 8231: 8182: 8177: 8172: 8162: 8128: 8118: 8002: 7992: 7982: 7927: 7897: 7877: 7681: 7664: 7588: 7557: 7522: 7512: 7473: 7440: 7435: 7414: 7374: 7359: 7349: 7334: 7329: 7303: 7293: 7288: 7258: 7253: 7247: 7242: 7237: 7214: 7204: 7173: 7158: 7137: 7110: 7053: 7018: 7003: 6993: 6965: 6878: 6863: 6823: 6812: 6792: 6777: 6746: 6741: 6067: 6045: 4926:

Guilleminault C (March 1990). "Benzodiazepines, breathing, and sleep".

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Goldney RD (1977). "Paradoxical reaction to a new minor tranquilizer".

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Lader M (1984). "Short-term versus long-term benzodiazepine therapy".

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Battaglia J (2005). "Pharmacological management of acute agitation".

2041: 1866: 1791: 1752: 1736: 1732: 1682: 1674: 1584: 1565:

also increase the risk of dependence and paradoxical adverse effects.

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becomes necessary, lorazepam may be used to facilitate deep sedation.

1175: 1119: 1049: 496: 435: 196: 100: 11207: 8846: 8831: 5949:"Review: lorazepam provides the best control for status epilepticus" 5569: 5135:

Olkkola KT, Ahonen J (2008). "Midazolam and Other Benzodiazepines".

2726: 1305: 16976: 16782: 16777: 16737: 16652: 16500: 16375: 16313: 15696: 15661: 15566: 15181: 15111: 15081: 15041: 14935: 14726: 14686: 14666: 14306: 14239: 14216: 14165: 14161: 14157: 14097: 14071: 13931: 13891: 13871: 13851: 13841: 13781: 13776: 13590: 13552: 13502: 13467: 13432: 13427: 13411: 13406: 13386: 13381: 13376: 13363: 13251: 13059: 12936: 12922: 12897: 12892: 12882: 12854: 12641: 12636: 12616: 12596: 12591: 12391: 12346: 12326: 12291: 12281: 12168: 12123: 12113: 12018: 11913: 11893: 11809: 11695: 11591: 11440: 11096: 11052: 11032: 11004: 10933: 10923: 10846: 10732: 10723: 10617: 10369: 10098: 10068: 9994: 9929: 9784: 9761: 9756: 9721: 9574: 9506: 9368: 9283: 9187: 9183: 9079: 9059: 8979: 8792: 8736: 8679: 8669: 8634: 8624: 8599: 8528: 8362: 8336: 8093: 8073: 7907: 7892: 7697: 7537: 7455: 7354: 7168: 7163: 7069: 7048: 7043: 7033: 7013: 6818: 5051: 2142: 2134: 1935: 1914: 1893: 1889: 1870: 1830: 1803: 1728: 1635: 1543: 1505: 1455: 1447: 1210:; the effects of lorazepam are increased in combination with other 1160: 1155: 1135: 1104: 1041: 1014: 926: 863: 590: 521: 142: 6686: 3636: 1556:– The risk of abuse of lorazepam is increased in dependent people. 1538:– Lorazepam may be safer than most benzodiazepines in people with 1454:

from the anterior chamber of the eye, thus worsening narrow-angle

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This article incorporates text from this source, which is in the

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Prasad M, Krishnan PR, Sequeira R, Al-Roomi K (September 2014).

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Tooltip G protein-coupled inwardly rectifying potassium channel

15984: 15980:

Tooltip G protein-coupled inwardly rectifying potassium channel

15656: 15576: 15459: 15449: 15231: 15000: 14186: 14149: 13771: 13724: 13595: 13577: 13537: 13221: 13019: 11024: 10728: 9880: 9776: 9089: 8816: 4401:"Mortality Risk of Hypnotics: Strengths and Limits of Evidence" 4119:"Benzodiazepines for psychosis-induced aggression or agitation" 3448:. International Review of Neurobiology. Vol. 81. pp. 2669:. American Society of Health-System Pharmacists. 29 June 2016. 2170: 1930:

binding (85–90%) mean its volume of distribution is mainly the

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in the neonate. Neonatal benzodiazepine withdrawal may include

1440: 1215: 934: 891: 621: 440: 6646:"Generic-Drug Maker Agrees to Settlement In Price-Fixing Case" 3347: 2335: 2087:

containing 2 or 4 mg of lorazepam. The solvents used are

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breast milk, so caution must be exercised about breastfeeding.

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Lorazepam injectable solution is administered either by deep

2020: 1815: 1433:– Lorazepam may interact synergistically with the effects of 750: 601: 392: 16259: 6404:"ABH gel is not absorbed from the skin of normal volunteers" 5609:"What makes lorazepam different from other benzodiazepines?" 2060:

in yellow tablets). Lorazepam for injection formulated with

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downregulation, alterations to subunit configuration of GABA

1048:. Lorazepam is more effective than diazepam and intravenous 646: 56: 17187:

Tooltip Cystic fibrosis transmembrane conductance regulator

17109: 16154: 15812: 15774: 15557: 12980: 9220: 4601:

10.1352/0895-8017(2002)107<0376:BBSERA>2.0.CO;2

2125: 1807: 581: 17083: 14388: 5348: 4116: 2944: 8768: 7563: 6567:

Substance Abuse and Mental Health Services Administration

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Matthew E, Andreason P, Pettigrew K, et al. (1995).

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in mouse spinal cord cell cultures, hence prolonging the

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is sometimes treated with lorazepam, but as it can cause

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may also occur. If stopped suddenly after long-term use,

15353: 5900:"Lorazepam or diazepam in paediatric status epilepticus" 5606: 5444:. Strassbourg: Council of Europe, Pompidou Group. 2002. 4543: 4065:

Huf G, Alexander J, Gandhi P, Allen MH (November 2016).

3791: 3523: 3152:"Disparities: Study Finds Risk in Off-Label Prescribing" 3084:. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO. 16044: 15864: 6227:

Sybirska E, Seibyl JP, Bremner JD, et al. (1993).

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Gillies D, Sampson S, Beck A, Rathbone J (April 2013).

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in the US and internationally under the United Nations

2015: 986:

World Health Organization's List of Essential Medicines

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for this purpose as it has not been proven effective.

2095:. As a preservative, the injectable solution contains 1703:, in a feature on the drug over a number of episodes. 1280:

can cause propylene glycol intoxication and poisoning.

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on memory than other benzodiazepines; it impairs both

1099:

Lorazepam is sometimes used for individuals receiving

1044:

or lorazepam are first-line treatments for convulsive

17423: 16341: 10593: 6369:"Five Things Physicians and Patients Should Question" 6320: 6278:

Journal of Pharmacology and Experimental Therapeutics

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occur with higher doses, in people with pre-existing

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Tooltip Serotonin antagonist and reuptake inhibitors

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Tooltip Serotonin-norepinephrine reuptake inhibitors

5486:. Amer. Assoc. for Clinical Chemistry. p. 216. 3710: 3209: 898:. It is also used, along with other treatments, for 8876: 6383:

American Academy of Hospice and Palliative Medicine

6365:

American Academy of Hospice and Palliative Medicine

5442:

Contribution to the sensible use of benzodiazepines

4473: 4349: 4306: 2763: 2396: 2192:Lorazepam is also used for other purposes, such as 2115:

American Academy of Hospice and Palliative Medicine

5513:. Lippincott Williams & Wilkins. p. 301. 5302:"Lorazepam: Patient Information Leaflet, UK, 1998" 4272:Herrstedt J, Aapro MS, Roila F, Kataja VV (2005). 3881: 2608:"Lorazepam Macure 4 mg/ml, solution for injection" 1778:Signs of overdose range through mental confusion, 17376: 16950: 14289:Unsorted benzodiazepine site positive modulators: 8861: 6092:Journal of Pharmaceutical and Biomedical Analysis 5607:Pompéia S, Manzano GM, Tufik S, Bueno OF (2005). 5506: 4656: 3990: 3988: 3952: 3950: 3948: 2773:Journal of Pharmaceutical and Biomedical Analysis 2347:. Cambridge University Press. 2010. p. 156. 2083:injection. The injectable solution comes in 1 mL 1829:Early management of people under alert includes 1587:, have the highest risk of causing a dependence. 1150:Lorazepam is sometimes used as an alternative to 17447: 17014: 6534: 6473: 5897: 3840: 2582:"Loreev XR- lorazepam capsule, extended release" 1619:of the benzodiazepine binding site from the GABA 1550:disease has minimal effects on lorazepam levels. 1214:drugs. Other adverse effects include confusion, 1024:, may occur after seven days' use of lorazepam. 963:larger doses may be required for the same effect 509: 17414:Transient receptor potential channel modulators 8821:Tooltip Selective serotonin reuptake inhibitors 6528: 6275: 5542:. Treasure Island (FL): StatPearls Publishing. 5467:Disposition of Toxic Drugs and Chemicals in Man 5391: 5233: 5130: 5128: 5126: 5047: 5045: 5043: 4209: 3350:"Anticonvulsant therapy for status epilepticus" 3047: 2024:0.5 mg tablets of the Ativan brand of lorazepam 1265:. Higher dosages appear to confer greater risk. 1036:Lorazepam 3mg scored tablets in a blister pack. 484: 10799: 9182: 6626:. UK Home Office. January 2006. Archived from 6555: 5561: 5342: 5236:The American Journal of Drug and Alcohol Abuse 4162: 4160: 4037: 3985: 3945: 3585: 3583: 3496: 3294: 3292: 2173:on lorazepam is expired in the United States. 1852:aggression to frustrating cues. Opportunistic 1739:inhibits the metabolism of lorazepam, whereas 1067:make intravenous use reliable for terminating 17501:World Health Organization essential medicines 17356:Tooltip Transient receptor potential channels 15846:Tooltip Inwardly rectifying potassium channel 14355: 11722: 11223: 10785: 10197:Serotonin antagonists and reuptake inhibitors 9168: 8475: 7784: 6702: 6314: 6082: 5999: 5946: 5692:Royal Pharmaceutical Society of Great Britain 5134: 5003: 4925: 4031: 3918: 3396: 3301:"Status epilepticus: an evidence based guide" 2302: 1594:. Due to the development of tolerance to the 1196:medications used to treat nausea and vomiting 16264:Tooltip Tandem pore domain potassium channel 6512:. non-benzodiazepines.org.uk. Archived from 6220: 6161: 6118: 6041: 6039: 6037: 6005: 5891: 5840: 5175: 5169: 5123: 5040: 4744: 4623: 4580: 4537: 4355: 4312: 4265: 4238: 3764: 3762: 3760: 3758: 3756: 3630: 3442:"Treatment of convulsive status epilepticus" 3433: 3390: 2978: 2976: 2940: 2938: 2894: 2892: 2890: 2888: 2886: 2884: 2882: 2880: 2878: 2876: 2845:The Primary Care Companion for CNS Disorders 2657: 2655: 2653: 2651: 2649: 1949:Diazepam has long been a drug of choice for 1402:Lorazepam should be avoided in people with: 839:a box of Lorazepam Orion (Lorazepam) tablets 146: 16162:Tooltip Calcium-activated potassium channel 11738: 10586: 8761: 6303:baxter.com – Lorazepam Injection Data Sheet 5799: 5720: 5655: 5568:Mandrioli R, Mercolini L, Raggi MA (2008). 5534:Kang M, Galuska MA, Ghassemzadeh S (2023). 5080: 4842: 4793: 4750: 4494: 4157: 4123:The Cochrane Database of Systematic Reviews 4071:The Cochrane Database of Systematic Reviews 3792:Maltais F, Laberge F, Laviolette M (1996). 3785: 3768: 3580: 3499:Journal of Intellectual Disability Research 3354:The Cochrane Database of Systematic Reviews 3289: 3168: 2647: 2645: 2643: 2641: 2639: 2637: 2635: 2633: 2631: 2629: 2296: 1859: 1569: 17481:Chemical substances for emergency medicine 17088:Tooltip Calcium-activated chloride channel 15380:4-Aminopyridine (fampridine/dalfampridine) 14393:Tooltip Voltage-dependent calcium channels 14369: 14362: 14348: 11729: 11715: 11230: 11216: 10792: 10778: 9175: 9161: 8482: 8468: 7791: 7777: 6709: 6695: 6357: 5846: 5086: 4836: 4707: 4629: 3834: 3589: 3439: 2834: 2832: 2306:Pharmacology for the Primary Care Provider 2220:Lorazepam is a Schedule IV drug under the 914:(on the skin via a topical gel or patch), 683: 660: 549: 7798: 6643: 6436: 6419: 6244: 6203: 6193: 6034: 5967: 5923: 5823: 5775: 5773: 5771: 5769: 5767: 5743: 5700:(v53 ed.). London: BMJ and RPS Pub. 5632: 5409: 5210: 4768: 4701: 4500: 4416: 4289: 4140: 4130: 4090: 3994: 3875: 3858: 3753: 3736: 3654: 3549: 3373: 3324: 3079: 2973: 2935: 2873: 2856: 2807:"Lorazepam: MedlinePlus Drug Information" 1390:Learn how and when to remove this message 569: 15358:Tooltip Voltage-gated potassium channels 6602:. August 2003. p. 7. Archived from 5464: 5392:Löscher W, Rogawski MA (December 2012). 5351:American Journal of the Medical Sciences 5304:. Genus Pharmaceuticals. 21 January 1998 4960: 3704: 3298: 3149: 3000:from the original on 17 September 2011. 2626: 2365: 2124: 2019: 1908:properties. It is a high-potency and an 1031: 884:chemotherapy-induced nausea and vomiting 834: 16052:Tooltip ATP-sensitive potassium channel 15872:Tooltip ATP-sensitive potassium channel 8504: 5507:Ries RK, Miller SC, Fiellin DA (2009). 5213:"Reasons for a diazepam (Valium) taper" 3927:Nederlands Tijdschrift voor Geneeskunde 3174: 3060: 3014: 2829: 1623:receptor complex as well as changes in 1130:lorazepam is sometimes used to produce 656: 529: 119: 14: 17448: 8561:Tooltip positive allosteric modulators 8544: 8489: 6408:Journal of Pain and Symptom Management 6127:Clinical Pharmacology and Therapeutics 6048:Clinical Pharmacology and Therapeutics 5995:from the original on 12 December 2006. 5764: 5752:from the original on 28 September 2007 5330:from the original on 27 September 2007 4802:Clinical Pharmacology and Therapeutics 4697:from the original on 13 December 2012. 4657:Mancuso CE, Tanzi MG, Gabay M (2004). 4589:American Journal on Mental Retardation 4441: 4398: 4212:Journal of Clinical Psychopharmacology 3446:The Neurobiology of Epilepsy and Aging 3255:Clinical Pharmacology and Therapeutics 3164:from the original on 19 February 2017. 2442: 2392:from the original on 8 September 2017. 2361:from the original on 8 September 2017. 2176: 674: 334: 16346:Tooltip Voltage-gated sodium channels 14343: 11710: 11237: 11211: 10773: 9156: 8463: 7772: 6690: 6600:International Narcotics Control Board 5887:from the original on 15 October 2003. 4112: 4110: 3210:Aschenbrenner DS, Venable SJ (2009). 3074:. Geneva: World Health Organization. 3021:A Historical Dictionary of Psychiatry 2838: 2228:. It is a Schedule IV drug under the 2226:Convention on Psychotropic Substances 1187:is sometimes given at the same time. 1103:. However, in critically ill people, 629: 609: 347: 137: 105: 16281:12-O-Tetradecanoylphorbol-13-acetate 14330:GABA metabolism/transport modulators 8896:Tooltip Monoamine oxidase inhibitors 6658:from the original on 14 October 2007 5479: 3177:Current Medical Research and Opinion 2984:"Ativan (lorazepam) Tablets Rx only" 2371: 2323:from the original on 14 January 2023 2309:(4th ed.). Mosby. p. 545. 2161:. Lorazepam was first introduced by 2016:Physical properties and formulations 1328:adding citations to reliable sources 1299: 1295: 1022:rebound insomnia and rebound anxiety 957:, there may be an increased risk of 886:. It is also used during surgery to 258: 15375:3,4-Diaminopyridine (amifampridine) 13947:Trichloroethane (methyl chloroform) 8881:Tooltip Tetracyclic antidepressants 6716: 4722:10.5694/j.1326-5377.1977.tb130567.x 3771:"Benzodiazepines and their effects" 3242:from the original on 19 April 2016. 3106:from the original on 30 August 2024 3037:from the original on 28 March 2017. 2817:from the original on 19 August 2016 2230:Controlled Drugs and Substances Act 2181: 1960: 1924: 1731:. Lorazepam may also interact with 782:O=C1Nc2ccc(Cl)cc2C(c2ccccc2Cl)=NC1O 589: 500: 24: 13010:11-Methoxy-12-hydroxydehydrokavain 5746:"Benzodiazepine equivalency table" 5723:"Benzodiazepine Equivalence Table" 5294: 5054:Annales Pharmaceutiques Françaises 4558:10.1097/01.fbp.0000170910.53415.77 4181:10.1002/j.1875-9114.1998.tb03827.x 4107: 3847:British Journal of Anaesthesiology 3608:10.1002/j.1875-9114.1996.tb02915.x 3572:: CS1 maint: overridden setting ( 2694:Journal of Pharmaceutical Sciences 2458:from the original on 3 August 2023 2284:from the original on 5 August 2016 2278:The Drug Gene Interaction Database 2113:, has been advised against by the 1662:benzodiazepine withdrawal syndrome 1592:benzodiazepine withdrawal symptoms 1517: 1494:benzodiazepine withdrawal syndrome 1201: 1181:benzodiazepine withdrawal syndrome 975:benzodiazepine withdrawal syndrome 25: 17522: 17381:Tooltip Ligand gated ion channels 16955:Tooltip Epithelial sodium channel 13757:Acetylglycinamide chloral hydrate 9902:Acetylglycinamide chloral hydrate 8866:Tooltip Tricyclic antidepressants 7753:* atypical activity profile (not 7691:Tetrahydroisoquinobenzodiazepines 6674: 6421:10.1016/j.jpainsymman.2011.05.017 5721:Nimmo R, Ashton CH (March 2007). 5282:from the original on 7 March 2008 5200:from the original on 12 May 2008. 3841:Heisterkamp DV, Cohen PJ (1975). 2006:from inactivation to deactivation 1258:complete withdrawal of lorazepam. 1154:when there is the need for rapid 918:(IV) (injection into a vein), or 285: 169: 17433: 17019:Tooltip Acid-sensing ion channel 6637: 6613: 6585: 6502: 6476:European Journal of Pharmacology 6467: 6296: 6269: 5940: 5510:Principles of Addiction Medicine 5101:10.2165/00003088-200847050-00002 4975:10.2165/00003495-198223050-00002 4928:The American Journal of Medicine 4907: 4857:10.1592/phco.2005.25.5_Part_2.8S 4224:10.1097/00004714-199608000-00007 4009:10.2165/00003495-200565090-00003 3896:10.2165/00002512-200421140-00001 3656:10.1111/j.1468-1331.2005.01247.x 3411:10.1016/j.eplepsyres.2005.07.020 2913:10.1111/j.1600-0404.2008.01004.x 2741:10.1097/00003246-200008000-00011 2673:from the original on 5 June 2016 2375:Principles of addiction medicine 1913:1 mg is equal in effect to 1304: 854:medication. It is used to treat 720: 714: 708: 64: 55: 14177:Menthyl isovalerate (validolum) 7733:Alprazolam triazolobenzophenone 5898:Choudhery V, Townend W (2006). 5737: 5714: 5680: 5649: 5619:(Pt 2): 709, author reply 710. 5600: 5527: 5500: 5473: 5458: 5434: 5385: 5326:. Patient UK. 25 October 2006. 5316: 5262: 5227: 5204: 4997: 4954: 4919: 4879: 4650: 4467: 4392: 4203: 4058: 3769:Hindmarch I (30 January 1997). 3679: 3517: 3490: 3341: 3246: 3203: 3143: 3118: 3088: 3041: 3008: 2799: 2720: 2685: 2612:European Medicines Agency (EMA) 2600: 2574: 2548: 2522: 2215: 1879: 1706: 1315:needs additional citations for 1020:Withdrawal symptoms, including 999: 888:interfere with memory formation 807:Key:DIWRORZWFLOCLC-UHFFFAOYSA-N 322: 14837:Ziconotide (ω-conotoxin MVIIA) 13126:Allopregnanolone (brexanolone) 6537:Journal of Clinical Psychiatry 6439:Journal of Palliative Medicine 5662:Journal of Clinical Psychiatry 4451:. RxList. 2007. Archived from 4132:10.1002/14651858.CD003079.pub3 4083:10.1002/14651858.CD005146.pub3 3366:10.1002/14651858.CD003723.pub3 2496: 2470: 2436: 2425: 2266: 1492:), carries a definite risk of 726: 702: 311: 298: 13: 1: 17410:Receptor/signaling modulators 14812:Leconotide (ω-conotoxin CVID) 14322:Receptor/signaling modulators 12878:Ampelopsin (dihydromyricetin) 6335:10.1592/phco.23.10.1094.32762 5947:Henry JC, Holloway R (2006). 4675:10.1592/phco.24.13.1177.38089 3643:European Journal of Neurology 3458:10.1016/S0074-7742(06)81018-4 2901:Acta Neurologica Scandinavica 2556:"Ativan- lorazepam injection" 2344:Clinical Addiction Psychiatry 2259: 2248:to settle accusations by the 2240:In 2000, the US drug company 1921:of lorazepam is 10–20 hours. 1810:, cardiovascular depression, 1642: 14072:ergoloid (dihydroergotoxine) 13157:anabolic-androgenic steroids 11939:Butabarbital/Secbutabarbital 11744:receptor positive modulators 6488:10.1016/0014-2999(78)90085-7 6246:10.1016/0028-3908(93)90080-M 6174:Proc. Natl. Acad. Sci. U.S.A 5825:10.1016/0376-8716(88)90021-X 5625:10.1113/jphysiol.2005.569005 5363:10.1097/MAJ.0b013e31814a586a 5176:Longo LP, Johnson B (2000). 5145:10.1007/978-3-540-74806-9_16 5066:10.1016/j.pharma.2009.07.001 5026:10.1016/0890-6238(94)90029-9 4940:10.1016/0002-9343(90)90282-I 4893:Food and Drug Administration 4710:Medical Journal of Australia 4247:Tijdschrift voor Psychiatrie 3729:10.1097/CCM.0B013E3181544248 2991:Food and Drug Administration 2303:Edmunds M, Mayhew M (2013). 1482:Food and Drug Administration 1286:Food and Drug Administration 1284:In September 2020, the U.S. 1220:long-term benzodiazepine use 1145: 925:Common side effects include 846:, sold under the brand name 407:1–5 min (IV), 15–30 min (IM) 7: 12712:Triflunordazepam (Ro5-2904) 10428:Tetracyclic antidepressants 10242:Tetracyclic antidepressants 5865:10.1592/phco.22.5.329.33192 5812:Drug and Alcohol Dependence 5688:British Medical Association 4399:Kripke DF (February 2016). 3150:Rabin RC (25 August 2009). 3023:. Oxford University Press. 1989:receptors, but require the 1763: 1693:, agitation, palpitations, 1554:Drug and alcohol dependence 1480:– Lorazepam belongs to the 1094: 1089:alcohol withdrawal syndrome 1027: 951:decreased effort to breathe 10: 17527: 16373:Antiarrhythmics (class I): 13040:5,6,7,8-Tetrahydroyangonin 6644:Labaton S (13 July 2000). 6621:"List of Controlled Drugs" 6104:10.1016/j.jpba.2005.07.033 5904:Emergency Medicine Journal 5697:British National Formulary 5586:10.2174/138920008786049258 5270:"Ativan Labeling Revision" 4751:Izaute M, Bacon E (2005). 3971:10.2174/138945005774574416 3542:10.1007/s40263-022-00940-2 2959:10.1016/j.smrv.2009.10.008 2785:10.1016/j.jpba.2005.07.021 2530:"Ativan- lorazepam tablet" 2454:(published 4 April 2023). 2235: 2185: 2120: 2042:microcrystalline cellulose 1767: 1004: 943:decreased memory formation 692:Chemical and physical data 326:: Prescription only ( 29: 17476:Drugs developed by Pfizer 17403: 17374: 17349: 17342: 17276: 17269: 17222: 17194: 17180: 17158: 17095: 17081: 17072: 17026: 17012: 16990: 16962: 16948: 16891: 16883:Tricyclic antidepressants 16353: 16339: 16330: 16304: 16271: 16257: 16201: 16169: 16152: 16033: 15892:Glibenclamide (glyburide) 15853: 15839: 15802: 15365: 15351: 15342: 15310: 14400: 14377: 14315: 13965: 13733: 13670: 13637: 13604: 13576: 13290: 13232:Pregnanolone (eltanolone) 13111: 13068: 12979: 12951: 12863: 12745: 12187: 11874: 11775:Chlorobutanol (cloretone) 11750: 11663: 11621: 11573: 11520: 11459: 11414: 11369: 11250: 11168: 11143: 11115: 11082: 11023: 10990: 10942: 10914: 10905: 10812: 10631: 10584: 10556: 10523: 10503: 10449: 10405:Tricyclic antidepressants 10390: 10378: 10321: 10263: 10219:Tricyclic antidepressants 10187: 10124: 10112: 10041: 9889: 9826: 9793: 9775: 9707: 9654: 9611: 9583: 9525: 9402: 9259: 9211: 9199: 9113: 9017: 8958: 8935: 8806: 8753: 8735: 8542: 8502: 8420: 8355: 8311: 8304: 8282: 8191: 8058: 8047: 8011: 7972: 7820: 7811: 7751: 7725: 7706: 7690: 7674: 7636: 7618: 7602: 7578: 7492: 7464: 7428: 7322: 7228: 7187: 7151: 6724: 5536:"Benzodiazepine Toxicity" 5248:10.3109/00952998209002608 5182:American Family Physician 5089:Clinical Pharmacokinetics 4418:10.1007/s40264-015-0362-0 3189:10.1185/03007998409109550 3068:World Health Organization 2222:Controlled Substances Act 1577:benzodiazepine dependence 1159:acutely psychotic. Acute 815: 790: 770: 748: 735: 696: 691: 672: 640: 620: 600: 580: 560: 540: 520: 495: 475: 451: 446: 434: 424: 411: 401: 386: 376: 368: 275: 270: 245: 233: 207: 195: 183: 157: 127: 113: 95: 87: 77: 72: 63: 54: 27:Benzodiazepine medication 17511:2-Chlorophenyl compounds 17471:Drugs developed by Wyeth 14326:GABA receptor modulators 14236:sulfonmethane (sulfonal) 11371:5-HT serotonin G-protein 9990:Sulfonmethane (sulfonal) 7620:Pyridotriazolodiazepines 7494:Thienotriazolodiazepines 5744:Ashton CH (April 2007). 5211:Ashton HC (April 2001). 4546:Behavioural Pharmacology 3813:10.1378/chest.109.5.1195 3317:10.1136/bmj.331.7518.673 2250:Federal Trade Commission 1860:Detection in body fluids 1570:Tolerance and dependence 1190:It is sometimes used in 1170: 971:psychological dependence 30:Not to be confused with 17496:Sodium channel blockers 16496:Eslicarbazepine acetate 10477:Atypical antipsychotics 10291:Atypical antipsychotics 8513:Tooltip 5-HT1A receptor 8151:Eslicarbazepine acetate 7726:Benzodiazepine prodrugs 7230:Triazolobenzodiazepines 6451:10.1089/jpm.2005.8.1135 6376:: an initiative of the 5956:Evidence Based Medicine 5916:10.1136/emj.2006.037606 5574:Current Drug Metabolism 5006:Reproductive Toxicology 4757:Neuropsychopharmacology 3213:Drug Therapy in Nursing 2839:Dodds TJ (March 2017). 2452:Diário Oficial da União 2077:intramuscular injection 2052:, and coloring agents ( 1770:Benzodiazepine overdose 1540:impaired liver function 1075:treatment of resistant 1065:pharmacokinetic profile 996:million prescriptions. 988:. It is available as a 900:acute coronary syndrome 896:mechanically ventilated 382:85% when taken by mouth 16240:Rottlerin (mallotoxin) 14371:Ion channel modulators 14212:Retigabine (ezogabine) 13488:Lirequinil (Ro41-3696) 13055:7,8-Dihydromethysticin 13045:5,6-Dehydromethysticin 11924:Benzylbutylbarbiturate 10651:Chlorophenylalkyldiols 10459:Typical antipsychotics 10273:Typical antipsychotics 8553:Tooltip GABAA receptor 7708:Pyrrolobenzodiazepines 7429:Oxazolobenzodiazepines 7323:Imidazobenzodiazepines 7306:(active metabolite of 6808:Desmethylflunitrazepam 6569:. 2006. Archived from 6510:"Benzodiazepine Names" 6195:10.1073/pnas.92.7.2775 6020:10.1093/qjmed/95.4.225 4770:10.1038/sj.npp.1300564 3717:Critical Care Medicine 2947:Sleep Medicine Reviews 2729:Critical Care Medicine 2706:10.1002/jps.2600680119 2130: 2025: 1812:respiratory depression 1500:, reluctance to suck, 1486:floppy infant syndrome 1425:mechanical ventilation 1101:mechanical ventilation 1037: 961:. With long-term use, 840: 14597:Ryodipine (riodipine) 7580:Thienobenzodiazepines 6139:10.1038/clpt.1989.101 6060:10.1002/cpt1976203329 5613:Journal of Physiology 4476:Clinical Therapeutics 4449:"Ativan side effects" 4327:10.1007/s002130050775 4291:10.1093/annonc/mdi805 4040:Revue Médicale Suisse 3096:"The Top 300 of 2022" 3049:US patent 3296249 2188:Benzodiazepine misuse 2163:Wyeth Pharmaceuticals 2128: 2023: 1867:urine drug screenings 1784:paradoxical reactions 1563:psychiatric disorders 1255:personality disorders 1079:; because of gradual 1035: 906:use. It can be given 838: 16586:Valproate semisodium 15117:Carboxyamidotriazole 15052:Gabapentin enacarbil 15032:Arbaclofen placarbil 14267:constituents (e.g., 14051:Deuterated etifoxine 13113:Neuroactive steroids 13083:Apronal (apronalide) 12935:constituents (e.g., 12552:N-Desalkylflurazepam 11446:Tetrahydrocannabinol 11373:receptor antagonists 11117:Neuroactive steroids 11084:Arylcyclohexylamines 10608:Gabapentin enacarbil 9656:Neuroactive steroids 9626:Apronal (apronalide) 8788:Gabapentin enacarbil 7188:2,3-Benzodiazepines* 6681:Lorazepam data sheet 5787:on 28 September 2007 5656:Chouinard G (2004). 4814:10.1038/clpt.1982.27 4284:(Suppl 1): i77–i79. 3959:Current Drug Targets 3405:(Suppl 1): S77–S82. 3267:10.1038/clpt.1982.27 3183:(Suppl 4): 120–126. 2858:10.4088/PCC.16r02037 2201:emergency department 2107:Topical formulations 2056:in blue tablets and 1919:biological half-life 1324:improve this article 1128:intensive care units 894:those who are being 430:12–24 hours (IV, IM) 307:(Psychoactive drugs) 17237:1,10-Phenanthroline 15794:Spooky toxin (SsTx) 14779:Tetrahydropalmatine 14060:dihydroergocryptine 13372:Pyrazolopyrimidines 13030:5,6-Dihydroyangonin 13015:7,8-Dihydroyangonin 12202:3-Hydroxyphenazepam 12044:Methylphenobarbital 11258:channel antagonists 10801:General anesthetics 7853:Methylphenobarbital 7528:Deschloroclotizolam 7152:1,5-Benzodiazepines 6974:-Desalkylflurazepam 6737:3-Hydroxyphenazepam 6725:1,4-Benzodiazepines 6609:on 5 December 2005. 6389:on 1 September 2013 6186:1995PNAS...92.2775M 5969:10.1136/ebm.11.2.54 5847:Lackner TE (2002). 5781:"Lorzem Data Sheet" 5275:. FDA. April 2007. 5018:1994RepTx...8..461M 4897:. 23 September 2020 3860:10.1093/bja/47.1.79 3590:Peppers MP (1996). 3440:Treiman DM (2007). 2177:Society and culture 2089:polyethylene glycol 2062:polyethylene glycol 1910:intermediate-acting 1654:physical dependence 1446:Acute narrow-angle 1421:acute severe asthma 1417:Respiratory failure 1288:(FDA) required the 1237:Paradoxical effects 1165:paradoxical effects 1124:palliative sedation 967:Physical dependence 939:decreased alertness 850:among others, is a 343:(Prescription only) 294:(Prescription only) 51: 17247:7,8-Benzoquinoline 17242:4,7-Phenanthroline 17232:1,7-Phenanthroline 16608:Local anesthetics: 16140:ML-297 (VU0456810) 15647:Diallyl trisulfide 15642:Dextropropoxyphene 15545:Tetraethylammonium 15252:Pinaverium bromide 15022:4-Methylpregabalin 14154:4-O-methylhonokiol 13817:Dichloralphenazone 13715:Methylmethaqualone 13292:Nonbenzodiazepines 13005:Desmethoxyyangonin 13000:11-Hydroxyyangonin 12995:11-Methoxyyangonin 12990:10-Methoxyyangonin 12377:Ethyl carfluzepate 11979:Cyclopentobarbital 11195:Never to phase III 10673:Diethylpropanediol 9955:Dichloralphenazone 9871:Methylmethaqualone 9709:Nonbenzodiazepines 9236:Diethylpropanediol 9140:Never to phase III 8447:Never to phase III 7637:Pyrazolodiazepines 6844:Ethyl carfluzepate 6651:The New York Times 6543:(Suppl 9): 31–41. 6516:on 8 December 2008 6308:7 May 2007 at the 5404:(Suppl 8): 12–25. 5137:Modern Anesthetics 4851:(5 Pt 2): 8S–18S. 4515:10.1007/BF00181949 4503:Psychopharmacology 4370:10.1007/bf02245638 4358:Psychopharmacology 4315:Psychopharmacology 4278:Annals of Oncology 3157:The New York Times 3015:Shorter E (2005). 2813:. 1 October 2010. 2131: 2050:magnesium stearate 2026: 1951:status epilepticus 1839:activated charcoal 1526:nonbenzodiazepines 1431:Acute intoxication 1208:low blood pressure 1046:status epilepticus 1038: 990:generic medication 947:low blood pressure 880:alcohol withdrawal 876:status epilepticus 841: 426:Duration of action 47: 17421: 17420: 17399: 17398: 17338: 17337: 17334: 17333: 17296:Meclofenamic acid 17265: 17264: 17176: 17175: 17068: 17067: 17064: 17063: 17008: 17007: 16944: 16943: 16818:RG7893 (GDC-0287) 16581:Valproate pivoxil 16471:Acetylpheneturide 16326: 16325: 16322: 16321: 16253: 16252: 16225:Meclofenamic acid 16188:Ethanol (alcohol) 16148: 16147: 16097:Minoxidil sulfate 15835: 15834: 15338: 15337: 15334: 15333: 15237:Otilonium bromide 15162:Ethanol (alcohol) 14926:ω-Conotoxin MVIIC 14662:Phenylalkylamines 14337: 14336: 14297:MRK-409 (MK-0343) 14068:dihydroergotamine 14011:potassium bromide 14005:compounds (e.g., 13952:Trichloroethylene 13720:Nitromethaqualone 13639:Pyrazolopyridines 13141:3α-Androstanediol 13035:7,8-Dihydrokavain 12387:Ethyl loflazepate 12164:Thiotetrabarbital 11780:Ethanol (alcohol) 11704: 11703: 11512:Trimethobenzamide 11205: 11204: 11164: 11163: 10982:Thiotetrabarbital 10887:Trichloroethylene 10767: 10766: 10519: 10518: 10317: 10316: 10037: 10036: 9918:Potassium bromide 9876:Nitromethaqualone 9384:Thiotetrabarbital 9231:Ethanol (alcohol) 9150: 9149: 8722:Ethanol (alcohol) 8630:Ethyl loflazepate 8457: 8456: 8416: 8415: 8300: 8299: 8284:Potassium openers 8202:Oxazolidinediones 8134:Valproate pivoxil 8099:Acetylpheneturide 8043: 8042: 7998:Valproate pivoxil 7974:GABA-T inhibitors 7944:potassium bromide 7766: 7765: 7675:Pyrrolodiazepines 7533:Deschloroetizolam 7502:α-Hydroxyetizolam 6854:Ethyl loflazepate 6233:Neuropharmacology 5707:978-0-85369-731-2 5668:(Suppl 5): 7–12. 5520:978-0-7817-7477-2 5465:Baselt R (2008). 5451:978-92-871-4751-6 5411:10.1111/epi.12025 5154:978-3-540-72813-9 4455:on 21 August 2007 4046:(27): 1810–1813. 3467:978-0-12-374018-2 3399:Epilepsy Research 3311:(7518): 673–677. 3299:Walker M (2005). 3227:978-0-7817-6587-9 3030:978-0-19-029201-0 2588:. 20 January 2023 2536:. 13 January 2023 2446:(31 March 2023). 2385:978-0-7817-7477-2 2354:978-1-139-49169-3 2316:978-0-323-08790-2 2194:recreational drug 2072:as preservative. 2010:refractory period 1947:Clinical example: 1917:10 mg). The 1652:drugs, can cause 1468:Myasthenia gravis 1400: 1399: 1392: 1374: 1296:Contraindications 860:anxiety disorders 833: 832: 761:Interactive image 642:CompTox Dashboard 351: 338: 330:for higher doses) 325: 314: 302: 289: 173: 140: 16:(Redirected from 17518: 17438: 17437: 17436: 17429: 17382: 17378: 17357: 17353: 17347: 17346: 17274: 17273: 17192: 17191: 17188: 17184: 17093: 17092: 17089: 17085: 17079: 17078: 17024: 17023: 17020: 17016: 16960: 16959: 16956: 16952: 16571:Sodium valproate 16486:Chlorphenacemide 16468:Anticonvulsants: 16351: 16350: 16347: 16343: 16337: 16336: 16286:Arachidonic acid 16269: 16268: 16265: 16261: 16167: 16166: 16163: 16159: 16136: 16132: 16053: 16049: 16005:Dextromethorphan 15981: 15977: 15873: 15869: 15851: 15850: 15847: 15843: 15363: 15362: 15359: 15355: 15349: 15348: 15321:L-type-selective 15132:Dimeditiapramine 15094:Others/unsorted: 14876:T-type-selective 14863:R-type-selective 14845:P-type-selective 14797:ω-Conotoxin GVIA 14787:N-type-selective 14417:Dihydropyridines 14411:L-type-selective 14398: 14397: 14394: 14390: 14384: 14383: 14364: 14357: 14350: 14341: 14340: 14056:Dihydroergolines 13973:3-Hydroxybutanal 13606:Piperidinediones 13339:Imidazopyridines 12873:6-Methylapigenin 12805:Hydroxyphenamate 12677:SH-053-R-CH3-2′F 12382:Ethyl dirazepate 12262:Chlordiazepoxide 12154:Thiobutabarbital 11866:Trifluoroethanol 11856:Trichloroethanol 11846:-Pentanol (2M2B) 11740: 11731: 11724: 11717: 11708: 11707: 11583:anticholinergics 11507:Thiethylperazine 11502:Prochlorperazine 11232: 11225: 11218: 11209: 11208: 10912: 10911: 10794: 10787: 10780: 10771: 10770: 10692:muscle relaxants 10595: 10592: 10388: 10387: 10122: 10121: 10059:4-Fluorophenibut 9795:Piperidinediones 9669:Allopregnanolone 9251:Trichloroethanol 9209: 9208: 9177: 9170: 9163: 9154: 9153: 8986:Alpha-2 agonists 8976:Alpha-1 blockers 8969: 8897: 8893: 8882: 8878: 8867: 8863: 8852: 8848: 8837: 8833: 8822: 8818: 8776: 8770: 8767: 8595:Chlordiazepoxide 8562: 8558: 8554: 8550: 8514: 8510: 8484: 8477: 8470: 8461: 8460: 8309: 8308: 8193:Calcium blockers 8104:Chlorphenacemide 8056: 8055: 8030:GAT-1 inhibitors 7818: 7817: 7793: 7786: 7779: 7770: 7769: 7603:Pyridodiazepines 7466:Thienodiazepines 7420:SH-053-R-CH3-2′F 7133:Triflunordazepam 6849:Ethyl dirazepate 6763:Chlordiazepoxide 6711: 6704: 6697: 6688: 6687: 6668: 6667: 6665: 6663: 6641: 6635: 6634: 6633:on 11 July 2009. 6632: 6625: 6617: 6611: 6610: 6608: 6597: 6589: 6583: 6582: 6580: 6578: 6573:on 16 March 2014 6559: 6553: 6552: 6532: 6526: 6525: 6523: 6521: 6506: 6500: 6499: 6471: 6465: 6462: 6445:(6): 1135–1143. 6433: 6423: 6397: 6396: 6394: 6385:, archived from 6361: 6355: 6354: 6329:(9): 1094–1099. 6318: 6312: 6300: 6294: 6293: 6273: 6267: 6266: 6248: 6224: 6218: 6217: 6207: 6197: 6180:(7): 2775–2779. 6165: 6159: 6158: 6122: 6116: 6115: 6086: 6080: 6079: 6043: 6032: 6031: 6003: 5997: 5996: 5994: 5971: 5953: 5944: 5938: 5937: 5927: 5895: 5889: 5888: 5844: 5838: 5837: 5827: 5803: 5797: 5796: 5794: 5792: 5777: 5762: 5761: 5759: 5757: 5741: 5735: 5734: 5732: 5730: 5718: 5712: 5711: 5684: 5678: 5677: 5653: 5647: 5646: 5636: 5604: 5598: 5597: 5565: 5559: 5558: 5556: 5554: 5531: 5525: 5524: 5504: 5498: 5497: 5480:Shaw LM (2001). 5477: 5471: 5470: 5462: 5456: 5455: 5438: 5432: 5431: 5413: 5389: 5383: 5382: 5346: 5340: 5339: 5337: 5335: 5320: 5314: 5313: 5311: 5309: 5298: 5292: 5291: 5289: 5287: 5281: 5274: 5266: 5260: 5259: 5231: 5225: 5224: 5222: 5220: 5208: 5202: 5201: 5188:(7): 2121–2128. 5173: 5167: 5166: 5132: 5121: 5120: 5084: 5078: 5077: 5049: 5038: 5037: 5001: 4995: 4994: 4958: 4952: 4951: 4923: 4917: 4911: 4910: 4906: 4904: 4902: 4883: 4877: 4876: 4840: 4834: 4833: 4797: 4791: 4790: 4772: 4748: 4742: 4741: 4705: 4699: 4698: 4669:(9): 1177–1185. 4654: 4648: 4647: 4627: 4621: 4620: 4584: 4578: 4577: 4541: 4535: 4534: 4498: 4492: 4491: 4471: 4465: 4464: 4462: 4460: 4445: 4439: 4438: 4420: 4396: 4390: 4389: 4353: 4347: 4346: 4310: 4304: 4303: 4293: 4269: 4263: 4262: 4242: 4236: 4235: 4207: 4201: 4200: 4164: 4155: 4154: 4144: 4134: 4114: 4105: 4104: 4094: 4077:(11): CD005146. 4062: 4056: 4055: 4035: 4029: 4028: 4003:(9): 1207–1222. 3992: 3983: 3982: 3954: 3943: 3942: 3922: 3916: 3915: 3879: 3873: 3872: 3862: 3838: 3832: 3831: 3830:on 7 April 2008. 3829: 3823:. Archived from 3807:(5): 1195–1198. 3798: 3789: 3783: 3782: 3780: 3778: 3766: 3751: 3750: 3740: 3708: 3702: 3701: 3683: 3677: 3676: 3658: 3634: 3628: 3627: 3587: 3578: 3577: 3571: 3563: 3553: 3521: 3515: 3514: 3494: 3488: 3487: 3437: 3431: 3430: 3394: 3388: 3387: 3377: 3345: 3339: 3338: 3328: 3296: 3287: 3286: 3250: 3244: 3243: 3207: 3201: 3200: 3172: 3166: 3165: 3147: 3141: 3140: 3138: 3136: 3122: 3116: 3115: 3113: 3111: 3092: 3086: 3085: 3083: 3064: 3058: 3057: 3056: 3052: 3045: 3039: 3038: 3012: 3006: 3005: 2999: 2988: 2980: 2971: 2970: 2942: 2933: 2932: 2896: 2871: 2870: 2860: 2836: 2827: 2826: 2824: 2822: 2803: 2797: 2796: 2767: 2761: 2760: 2735:(8): 2750–2757. 2724: 2718: 2717: 2689: 2683: 2682: 2680: 2678: 2659: 2624: 2623: 2621: 2619: 2604: 2598: 2597: 2595: 2593: 2578: 2572: 2571: 2569: 2567: 2552: 2546: 2545: 2543: 2541: 2526: 2520: 2519: 2517: 2515: 2500: 2494: 2493: 2491: 2489: 2474: 2468: 2467: 2465: 2463: 2440: 2434: 2429: 2423: 2422: 2420: 2418: 2408:nctr-crs.fda.gov 2400: 2394: 2393: 2372:Ries RK (2009). 2369: 2363: 2362: 2339: 2333: 2332: 2330: 2328: 2300: 2294: 2293: 2291: 2289: 2270: 2247: 2182:Recreational use 2093:propylene glycol 2066:propylene glycol 1991:neurotransmitter 1961:Pharmacodynamics 1925:Pharmacokinetics 1911: 1411:hypersensitivity 1395: 1388: 1384: 1381: 1375: 1373: 1332: 1308: 1300: 1248:may also occur. 1077:absence seizures 995: 868:severe agitation 864:trouble sleeping 829: 828: 821: 763: 743: 728: 722: 716: 710: 704: 687: 676: 665: 664: 650: 648: 633: 613: 593: 573: 553: 533: 513: 503: 502: 488: 416: 356: 349: 346: 336: 333: 324: 321: 313: 310: 300: 297: 287: 284: 262: 171: 168: 150: 139: 136: 123: 109: 68: 59: 52: 50: 46: 21: 17526: 17525: 17521: 17520: 17519: 17517: 17516: 17515: 17466:Benzodiazepines 17446: 17445: 17444: 17434: 17432: 17424: 17422: 17417: 17395: 17380: 17370: 17355: 17330: 17326:Trifluoperazine 17321:Tolfenamic acid 17291:Flufenamic acid 17261: 17218: 17186: 17172: 17154: 17120:Flufenamic acid 17115:Ethacrynic acid 17087: 17060: 17018: 17004: 16986: 16954: 16940: 16887: 16718:Metabutoxycaine 16683:Diphenhydramine 16673:Cyclomethycaine 16638:Levobupivacaine 16345: 16318: 16300: 16263: 16249: 16245:Tolfenamic acid 16220:Flufenamic acid 16215: 16197: 16183: 16161: 16158: 16144: 16134: 16051: 16048: 16029: 15979: 15871: 15868: 15845: 15831: 15816: 15798: 15778: 15687:Norpropoxyphene 15564:11.1)-specific: 15563: 15357: 15330: 15306: 15262:Rhynchophylline 15012: 14392: 14373: 14368: 14338: 14333: 14311: 14269:isovaleric acid 14232:Sulfonylalkanes 14130:Hopantenic acid 14114:tolfenamic acid 14102:flufenamic acid 14064:dihydroergosine 14007:lithium bromide 13966:Others/unsorted 13961: 13822:Dichloromethane 13797:Chloral hydrate 13792:Chloral betaine 13729: 13666: 13633: 13600: 13572: 13301:Cyclopyrrolones 13286: 13192:Etiocholanolone 13107: 13064: 13025:5-Hydroxykavain 12975: 12947: 12859: 12741: 12189:Benzodiazepines 12183: 11994:Ethallobarbital 11989:Enallylpropymal 11870: 11851:Tribromoethanol 11838:-Butanol (2M2P) 11784:alcoholic drink 11746: 11743: 11735: 11705: 11700: 11659: 11626: 11617: 11597:Diphenhydramine 11580: 11569: 11550:Diphenhydramine 11528: 11525: 11516: 11468: 11464: 11455: 11424: 11419: 11410: 11372: 11365: 11257: 11255: 11246: 11236: 11206: 11201: 11200: 11185:Clinical trials 11160: 11139: 11111: 11078: 11019: 10992:Benzodiazepines 10986: 10938: 10901: 10808: 10798: 10768: 10763: 10627: 10590: 10580: 10552: 10515: 10499: 10445: 10392:Antidepressants 10383: 10374: 10345:Dexmedetomidine 10326: 10313: 10259: 10189:Antidepressants 10183: 10144:Diphenhydramine 10117: 10108: 10046: 10033: 10022:Isovaleric acid 9985:Sulfonylalkanes 9940:Chloral hydrate 9935:Chloral betaine 9913:Lithium bromide 9885: 9822: 9789: 9771: 9703: 9650: 9607: 9579: 9521: 9404:Benzodiazepines 9398: 9304:Ethallobarbital 9255: 9204: 9195: 9181: 9151: 9146: 9145: 9130:Clinical trials 9109: 9013: 8994:dexmedetomidine 8966:Antiadrenergics 8963: 8962: 8954: 8931: 8895: 8880: 8865: 8850: 8835: 8820: 8808:Antidepressants 8802: 8765: 8758: 8757: 8749: 8731: 8570:Benzodiazepines 8560: 8552: 8548: 8538: 8512: 8508: 8498: 8488: 8458: 8453: 8452: 8437:Clinical trials 8412: 8351: 8296: 8278: 8187: 8060:Sodium blockers 8050: 8039: 8007: 7968: 7888:Benzodiazepines 7825: 7807: 7800:Anticonvulsants 7797: 7767: 7762: 7758: 7747: 7721: 7702: 7686: 7670: 7632: 7614: 7598: 7574: 7488: 7460: 7424: 7318: 7224: 7183: 7147: 6720: 6718:Benzodiazepines 6715: 6677: 6672: 6671: 6661: 6659: 6642: 6638: 6630: 6623: 6619: 6618: 6614: 6606: 6595: 6591: 6590: 6586: 6576: 6574: 6561: 6560: 6556: 6533: 6529: 6519: 6517: 6508: 6507: 6503: 6472: 6468: 6392: 6390: 6378:ABIM Foundation 6374:Choosing Wisely 6362: 6358: 6323:Pharmacotherapy 6319: 6315: 6310:Wayback Machine 6301: 6297: 6274: 6270: 6225: 6221: 6166: 6162: 6123: 6119: 6087: 6083: 6044: 6035: 6004: 6000: 5992: 5951: 5945: 5941: 5896: 5892: 5853:Pharmacotherapy 5845: 5841: 5804: 5800: 5790: 5788: 5779: 5778: 5765: 5755: 5753: 5742: 5738: 5728: 5726: 5719: 5715: 5708: 5685: 5681: 5654: 5650: 5605: 5601: 5566: 5562: 5552: 5550: 5532: 5528: 5521: 5505: 5501: 5494: 5478: 5474: 5463: 5459: 5452: 5440: 5439: 5435: 5390: 5386: 5347: 5343: 5333: 5331: 5322: 5321: 5317: 5307: 5305: 5300: 5299: 5295: 5285: 5283: 5279: 5272: 5268: 5267: 5263: 5232: 5228: 5218: 5216: 5209: 5205: 5174: 5170: 5155: 5133: 5124: 5085: 5081: 5050: 5041: 5002: 4998: 4959: 4955: 4934:(3A): 25S–28S. 4924: 4920: 4908: 4900: 4898: 4885: 4884: 4880: 4845:Pharmacotherapy 4841: 4837: 4798: 4794: 4749: 4745: 4706: 4702: 4663:Pharmacotherapy 4655: 4651: 4628: 4624: 4585: 4581: 4542: 4538: 4499: 4495: 4472: 4468: 4458: 4456: 4447: 4446: 4442: 4397: 4393: 4354: 4350: 4311: 4307: 4270: 4266: 4243: 4239: 4208: 4204: 4169:Pharmacotherapy 4165: 4158: 4125:(4): CD003079. 4115: 4108: 4063: 4059: 4036: 4032: 3993: 3986: 3955: 3946: 3923: 3919: 3890:(14): 895–910. 3880: 3876: 3839: 3835: 3827: 3796: 3790: 3786: 3776: 3774: 3767: 3754: 3709: 3705: 3685: 3684: 3680: 3635: 3631: 3596:Pharmacotherapy 3588: 3581: 3565: 3564: 3522: 3518: 3495: 3491: 3468: 3438: 3434: 3395: 3391: 3360:(9): CD003723. 3346: 3342: 3297: 3290: 3251: 3247: 3228: 3208: 3204: 3173: 3169: 3148: 3144: 3134: 3132: 3124: 3123: 3119: 3109: 3107: 3094: 3093: 3089: 3065: 3061: 3054: 3046: 3042: 3031: 3013: 3009: 2997: 2986: 2982: 2981: 2974: 2943: 2936: 2897: 2874: 2837: 2830: 2820: 2818: 2811:medlineplus.gov 2805: 2804: 2800: 2768: 2764: 2725: 2721: 2690: 2686: 2676: 2674: 2661: 2660: 2627: 2617: 2615: 2606: 2605: 2601: 2591: 2589: 2580: 2579: 2575: 2565: 2563: 2554: 2553: 2549: 2539: 2537: 2528: 2527: 2523: 2513: 2511: 2502: 2501: 2497: 2487: 2485: 2484:. 22 April 2021 2476: 2475: 2471: 2461: 2459: 2441: 2437: 2430: 2426: 2416: 2414: 2402: 2401: 2397: 2386: 2370: 2366: 2355: 2341: 2340: 2336: 2326: 2324: 2317: 2301: 2297: 2287: 2285: 2272: 2271: 2267: 2262: 2246:US$ 147 million 2245: 2238: 2218: 2190: 2184: 2179: 2123: 2018: 2002:sodium channels 1988: 1984: 1980: 1976: 1963: 1927: 1909: 1906:muscle relaxant 1882: 1862: 1772: 1766: 1709: 1666:Rebound effects 1645: 1625:gene expression 1622: 1617:internalisation 1610: 1604: 1572: 1520: 1518:Specific groups 1508:, and impaired 1490:third trimester 1396: 1385: 1379: 1376: 1333: 1331: 1321: 1309: 1298: 1229:implicit memory 1204: 1202:Adverse effects 1194:in addition to 1173: 1148: 1097: 1063:properties and 1030: 1007: 1002: 993: 920:intramuscularly 824: 822: 819:(what is this?) 816: 811: 808: 803: 798: 797: 786: 783: 778: 777: 766: 741: 731: 725: 719: 713: 707: 668: 644: 636: 616: 596: 576: 556: 536: 516: 499: 491: 471: 468: 459: 458: 414: 403:Onset of action 396:glucuronidation 378:Bioavailability 370:Pharmacokinetic 364: 354: 266: 210: 198: 186: 179: 160: 153: 91:o-Chloroxazepam 43: 28: 23: 22: 15: 12: 11: 5: 17524: 17514: 17513: 17508: 17503: 17498: 17493: 17488: 17483: 17478: 17473: 17468: 17463: 17458: 17443: 17442: 17419: 17418: 17404: 17401: 17400: 17397: 17396: 17394: 17393: 17385: 17383: 17372: 17371: 17369: 17368: 17360: 17358: 17344: 17340: 17339: 17336: 17335: 17332: 17331: 17329: 17328: 17323: 17318: 17313: 17308: 17303: 17301:Mefenamic acid 17298: 17293: 17288: 17282: 17280: 17271: 17267: 17266: 17263: 17262: 17260: 17259: 17257:Phenanthridine 17254: 17249: 17244: 17239: 17234: 17228: 17226: 17220: 17219: 17217: 17216: 17211: 17206: 17200: 17198: 17189: 17178: 17177: 17174: 17173: 17171: 17170: 17164: 17162: 17156: 17155: 17153: 17152: 17147: 17142: 17137: 17132: 17127: 17122: 17117: 17112: 17107: 17101: 17099: 17090: 17076: 17070: 17069: 17066: 17065: 17062: 17061: 17059: 17058: 17053: 17048: 17043: 17038: 17032: 17030: 17021: 17010: 17009: 17006: 17005: 17003: 17002: 16996: 16994: 16988: 16987: 16985: 16984: 16979: 16974: 16968: 16966: 16957: 16946: 16945: 16942: 16941: 16939: 16938: 16933: 16928: 16923: 16918: 16905:Atracotoxins ( 16903: 16897: 16895: 16889: 16888: 16886: 16885: 16880: 16875: 16865: 16860: 16851: 16850: 16848:Zetekitoxin AB 16845: 16840: 16835: 16830: 16821: 16820: 16815: 16810: 16805: 16800: 16795: 16790: 16785: 16780: 16775: 16766: 16765: 16760: 16755: 16750: 16748:Proxymetacaine 16745: 16740: 16735: 16730: 16725: 16720: 16715: 16710: 16705: 16700: 16695: 16690: 16685: 16680: 16675: 16670: 16665: 16660: 16658:Chloroprocaine 16655: 16650: 16645: 16631: 16626: 16621: 16616: 16604: 16603: 16598: 16593: 16588: 16583: 16578: 16573: 16568: 16563: 16558: 16553: 16548: 16543: 16538: 16533: 16528: 16523: 16518: 16513: 16508: 16503: 16498: 16493: 16488: 16483: 16478: 16473: 16464: 16463: 16458: 16453: 16448: 16443: 16438: 16433: 16428: 16423: 16418: 16413: 16408: 16403: 16398: 16393: 16388: 16383: 16378: 16369: 16368: 16359: 16357: 16348: 16334: 16328: 16327: 16324: 16323: 16320: 16319: 16317: 16316: 16310: 16308: 16302: 16301: 16299: 16298: 16293: 16288: 16283: 16277: 16275: 16266: 16255: 16254: 16251: 16250: 16248: 16247: 16242: 16237: 16232: 16227: 16222: 16213: 16207: 16205: 16199: 16198: 16196: 16195: 16190: 16181: 16175: 16173: 16164: 16156: 16150: 16149: 16146: 16145: 16143: 16142: 16125: 16124: 16119: 16114: 16109: 16104: 16099: 16094: 16089: 16084: 16079: 16074: 16069: 16064: 16059: 16046: 16039: 16037: 16031: 16030: 16028: 16027: 16022: 16017: 16012: 16007: 16002: 15997: 15992: 15987: 15970: 15969: 15964: 15959: 15954: 15949: 15944: 15939: 15934: 15932:Glyclopyramide 15929: 15924: 15919: 15914: 15909: 15904: 15899: 15894: 15889: 15887:Chlorpropamide 15884: 15879: 15866: 15859: 15857: 15848: 15837: 15836: 15833: 15832: 15830: 15829: 15824: 15814: 15808: 15806: 15800: 15799: 15797: 15796: 15791: 15786: 15776: 15770: 15769: 15764: 15759: 15754: 15749: 15744: 15739: 15734: 15729: 15724: 15719: 15714: 15709: 15704: 15699: 15694: 15689: 15684: 15679: 15674: 15669: 15664: 15659: 15654: 15649: 15644: 15639: 15634: 15632:Clarithromycin 15629: 15624: 15622:Chlorpromazine 15619: 15614: 15609: 15604: 15599: 15594: 15589: 15584: 15579: 15574: 15569: 15561: 15553: 15552: 15547: 15542: 15537: 15532: 15527: 15522: 15517: 15512: 15507: 15502: 15497: 15492: 15487: 15482: 15477: 15472: 15467: 15462: 15457: 15452: 15447: 15442: 15437: 15432: 15427: 15422: 15417: 15412: 15407: 15402: 15397: 15392: 15387: 15382: 15377: 15371: 15369: 15360: 15346: 15340: 15339: 15336: 15335: 15332: 15331: 15329: 15328: 15316: 15314: 15308: 15307: 15305: 15304: 15299: 15294: 15289: 15284: 15279: 15274: 15269: 15264: 15259: 15254: 15249: 15244: 15242:Paramethadione 15239: 15234: 15229: 15224: 15219: 15214: 15209: 15204: 15199: 15194: 15189: 15184: 15179: 15174: 15169: 15164: 15159: 15154: 15149: 15144: 15139: 15134: 15129: 15124: 15119: 15114: 15109: 15104: 15099: 15090: 15089: 15084: 15079: 15074: 15069: 15064: 15059: 15054: 15049: 15044: 15039: 15034: 15029: 15024: 15017:gabapentinoids 15010: 15004: 15003: 14998: 14993: 14988: 14983: 14978: 14973: 14968: 14963: 14958: 14953: 14948: 14943: 14938: 14933: 14928: 14923: 14918:Non-selective: 14914: 14913: 14908: 14903: 14898: 14893: 14888: 14883: 14871: 14870: 14858: 14857: 14855:ω-Agatoxin IVB 14852: 14850:ω-Agatoxin IVA 14840: 14839: 14834: 14829: 14824: 14819: 14814: 14809: 14807:Huwentoxin XVI 14804: 14799: 14794: 14782: 14781: 14776: 14771: 14766: 14761: 14759:Cyproheptadine 14756: 14751: 14746: 14741: 14729: 14724: 14719: 14714: 14709: 14704: 14699: 14694: 14689: 14684: 14679: 14674: 14669: 14654: 14649: 14644: 14639: 14624: 14619: 14614: 14609: 14604: 14599: 14594: 14589: 14584: 14579: 14574: 14569: 14564: 14559: 14554: 14549: 14544: 14539: 14534: 14529: 14524: 14519: 14517:Levniguldipine 14514: 14509: 14504: 14499: 14494: 14489: 14484: 14479: 14474: 14469: 14464: 14459: 14457:Dexniguldipine 14454: 14449: 14444: 14439: 14434: 14429: 14424: 14406: 14404: 14395: 14381: 14375: 14374: 14367: 14366: 14359: 14352: 14344: 14335: 14334: 14316: 14313: 14312: 14310: 14309: 14304: 14299: 14294: 14285: 14284: 14277:valerenic acid 14262: 14257: 14247: 14229: 14224: 14219: 14214: 14209: 14204: 14199: 14194: 14189: 14184: 14179: 14174: 14169: 14147: 14142: 14137: 14132: 14127: 14122: 14117: 14106:mefenamic acid 14095: 14090: 14085: 14080: 14075: 14053: 14048: 14043: 14038: 14033: 14028: 14023: 14018: 14015:sodium bromide 14000: 13990: 13985: 13980: 13975: 13969: 13967: 13963: 13962: 13960: 13959: 13954: 13949: 13944: 13939: 13934: 13929: 13924: 13919: 13914: 13909: 13904: 13899: 13894: 13889: 13884: 13882:Methoxypropane 13879: 13877:Methoxyflurane 13874: 13869: 13864: 13859: 13854: 13849: 13844: 13839: 13837:Ethyl chloride 13834: 13829: 13824: 13819: 13814: 13809: 13804: 13799: 13794: 13789: 13784: 13779: 13774: 13769: 13764: 13759: 13754: 13749: 13743: 13741: 13731: 13730: 13728: 13727: 13722: 13717: 13712: 13707: 13702: 13697: 13692: 13687: 13682: 13676: 13674: 13672:Quinazolinones 13668: 13667: 13665: 13664: 13659: 13654: 13649: 13643: 13641: 13635: 13634: 13632: 13631: 13626: 13621: 13616: 13610: 13608: 13602: 13601: 13599: 13598: 13593: 13588: 13582: 13580: 13574: 13573: 13571: 13570: 13565: 13560: 13555: 13550: 13545: 13540: 13535: 13530: 13525: 13520: 13515: 13510: 13505: 13500: 13495: 13490: 13485: 13480: 13475: 13470: 13465: 13460: 13455: 13450: 13445: 13440: 13435: 13430: 13425: 13415: 13414: 13409: 13404: 13399: 13394: 13389: 13384: 13379: 13367: 13366: 13361: 13356: 13351: 13346: 13334: 13333: 13328: 13323: 13318: 13313: 13308: 13296: 13294: 13288: 13287: 13285: 13284: 13279: 13274: 13269: 13264: 13259: 13254: 13249: 13244: 13239: 13234: 13229: 13224: 13219: 13214: 13209: 13204: 13199: 13194: 13189: 13184: 13179: 13174: 13169: 13164: 13159: 13153: 13148: 13143: 13138: 13133: 13128: 13123: 13117: 13115: 13109: 13108: 13106: 13105: 13100: 13095: 13090: 13085: 13080: 13074: 13072: 13066: 13065: 13063: 13062: 13057: 13052: 13047: 13042: 13037: 13032: 13027: 13022: 13017: 13012: 13007: 13002: 12997: 12992: 12986: 12984: 12977: 12976: 12974: 12973: 12968: 12963: 12957: 12955: 12949: 12948: 12946: 12945: 12940: 12930: 12925: 12920: 12915: 12910: 12905: 12900: 12895: 12890: 12885: 12880: 12875: 12869: 12867: 12861: 12860: 12858: 12857: 12852: 12847: 12842: 12837: 12832: 12827: 12822: 12817: 12812: 12807: 12802: 12797: 12792: 12787: 12782: 12777: 12772: 12767: 12762: 12757: 12751: 12749: 12743: 12742: 12740: 12739: 12734: 12729: 12724: 12719: 12714: 12709: 12704: 12699: 12694: 12689: 12684: 12679: 12674: 12669: 12664: 12659: 12654: 12649: 12644: 12639: 12634: 12629: 12624: 12619: 12614: 12609: 12604: 12599: 12594: 12589: 12584: 12579: 12574: 12569: 12564: 12559: 12554: 12549: 12544: 12539: 12534: 12529: 12524: 12519: 12514: 12509: 12504: 12499: 12494: 12489: 12484: 12479: 12474: 12469: 12464: 12459: 12454: 12449: 12444: 12439: 12434: 12429: 12424: 12419: 12414: 12409: 12404: 12399: 12394: 12389: 12384: 12379: 12374: 12369: 12364: 12359: 12354: 12349: 12344: 12339: 12334: 12329: 12324: 12319: 12314: 12309: 12304: 12299: 12294: 12289: 12284: 12279: 12274: 12269: 12264: 12259: 12254: 12249: 12244: 12239: 12234: 12229: 12224: 12219: 12214: 12209: 12204: 12199: 12193: 12191: 12185: 12184: 12182: 12181: 12176: 12171: 12166: 12161: 12156: 12151: 12146: 12141: 12136: 12131: 12126: 12121: 12116: 12111: 12106: 12101: 12096: 12094:Propylbarbital 12091: 12086: 12081: 12076: 12071: 12066: 12061: 12056: 12051: 12046: 12041: 12036: 12031: 12026: 12021: 12016: 12011: 12006: 12001: 11996: 11991: 11986: 11981: 11976: 11971: 11969:Crotylbarbital 11966: 11961: 11956: 11951: 11946: 11941: 11936: 11934:Brophebarbital 11931: 11929:Brallobarbital 11926: 11921: 11916: 11911: 11906: 11901: 11896: 11891: 11886: 11880: 11878: 11872: 11871: 11869: 11868: 11863: 11858: 11853: 11848: 11840: 11832: 11827: 11822: 11817: 11815:Methylpentynol 11812: 11807: 11802: 11797: 11792: 11787: 11777: 11772: 11767: 11762: 11756: 11754: 11748: 11747: 11741: 11734: 11733: 11726: 11719: 11711: 11702: 11701: 11699: 11698: 11693: 11688: 11683: 11678: 11676:Cerium oxalate 11673: 11667: 11665: 11661: 11660: 11658: 11657: 11652: 11647: 11642: 11637: 11631: 11629: 11624: 11619: 11618: 11616: 11615: 11610: 11605: 11599: 11594: 11588: 11586: 11571: 11570: 11568: 11567: 11562: 11557: 11552: 11547: 11545:Dimenhydrinate 11542: 11536: 11534: 11531:antihistamines 11523: 11518: 11517: 11515: 11514: 11509: 11504: 11499: 11494: 11492:Metoclopramide 11489: 11484: 11479: 11477:Chlorpromazine 11473: 11471: 11466: 11462: 11457: 11456: 11454: 11453: 11443: 11438: 11432: 11430: 11417: 11412: 11411: 11409: 11408: 11403: 11398: 11393: 11388: 11386:Cyproheptadine 11383: 11377: 11375: 11367: 11366: 11364: 11363: 11358: 11353: 11348: 11343: 11338: 11328: 11323: 11318: 11313: 11308: 11303: 11298: 11293: 11288: 11283: 11278: 11273: 11268: 11262: 11260: 11253: 11248: 11247: 11235: 11234: 11227: 11220: 11212: 11203: 11202: 11199: 11198: 11197: 11196: 11193: 11182: 11176: 11170: 11169: 11166: 11165: 11162: 11161: 11159: 11158: 11153: 11147: 11145: 11141: 11140: 11138: 11137: 11132: 11127: 11121: 11119: 11113: 11112: 11110: 11109: 11104: 11099: 11094: 11088: 11086: 11080: 11079: 11077: 11076: 11071: 11065: 11060: 11055: 11050: 11045: 11040: 11035: 11029: 11027: 11021: 11020: 11018: 11017: 11012: 11007: 11002: 10996: 10994: 10988: 10987: 10985: 10984: 10979: 10974: 10969: 10964: 10959: 10954: 10948: 10946: 10940: 10939: 10937: 10936: 10931: 10926: 10920: 10918: 10909: 10903: 10902: 10900: 10899: 10894: 10889: 10884: 10879: 10874: 10872:Methoxypropane 10869: 10867:Methoxyflurane 10864: 10859: 10854: 10849: 10844: 10839: 10834: 10829: 10824: 10818: 10816: 10810: 10809: 10797: 10796: 10789: 10782: 10774: 10765: 10764: 10762: 10761: 10756: 10751: 10746: 10741: 10739:Passion flower 10736: 10726: 10721: 10720: 10719: 10714: 10709: 10704: 10699: 10685: 10680: 10675: 10670: 10669: 10668: 10663: 10658: 10648: 10647: 10646: 10635: 10633: 10629: 10628: 10626: 10625: 10620: 10615: 10610: 10605: 10599: 10597: 10588: 10582: 10581: 10579: 10578: 10573: 10568: 10562: 10560: 10554: 10553: 10551: 10550: 10545: 10540: 10535: 10529: 10527: 10521: 10520: 10517: 10516: 10514: 10513: 10507: 10505: 10501: 10500: 10498: 10497: 10496: 10495: 10489: 10484: 10474: 10473: 10472: 10466: 10464:Chlorpromazine 10455: 10453: 10451:Antipsychotics 10447: 10446: 10444: 10443: 10442: 10441: 10435: 10425: 10424: 10423: 10417: 10412: 10402: 10396: 10394: 10385: 10381: 10376: 10375: 10373: 10372: 10367: 10362: 10357: 10352: 10347: 10342: 10337: 10331: 10329: 10324: 10319: 10318: 10315: 10314: 10312: 10311: 10310: 10309: 10303: 10298: 10288: 10287: 10286: 10280: 10278:Chlorpromazine 10269: 10267: 10265:Antipsychotics 10261: 10260: 10258: 10257: 10256: 10255: 10249: 10239: 10238: 10237: 10231: 10226: 10216: 10215: 10214: 10209: 10204: 10193: 10191: 10185: 10184: 10182: 10181: 10176: 10171: 10166: 10161: 10156: 10151: 10146: 10141: 10139:Cyproheptadine 10136: 10130: 10128: 10126:Antihistamines 10119: 10115: 10110: 10109: 10107: 10106: 10101: 10096: 10091: 10086: 10083:sodium oxybate 10076: 10071: 10066: 10061: 10056: 10054:1,4-Butanediol 10050: 10048: 10044: 10039: 10038: 10035: 10034: 10032: 10031: 10030: 10029: 10027:Valerenic acid 10024: 10019: 10009: 10004: 10003: 10002: 9997: 9992: 9982: 9977: 9972: 9967: 9962: 9957: 9952: 9947: 9942: 9937: 9932: 9927: 9926: 9925: 9923:Sodium bromide 9920: 9915: 9904: 9899: 9893: 9891: 9887: 9886: 9884: 9883: 9878: 9873: 9868: 9863: 9858: 9853: 9848: 9843: 9838: 9832: 9830: 9828:Quinazolinones 9824: 9823: 9821: 9820: 9815: 9810: 9805: 9799: 9797: 9791: 9790: 9788: 9787: 9781: 9779: 9773: 9772: 9770: 9769: 9764: 9759: 9754: 9749: 9744: 9739: 9734: 9729: 9724: 9719: 9713: 9711: 9705: 9704: 9702: 9701: 9696: 9691: 9686: 9681: 9676: 9671: 9666: 9660: 9658: 9652: 9651: 9649: 9648: 9643: 9638: 9633: 9628: 9623: 9617: 9615: 9609: 9608: 9606: 9605: 9600: 9595: 9589: 9587: 9581: 9580: 9578: 9577: 9572: 9567: 9562: 9557: 9552: 9547: 9542: 9537: 9531: 9529: 9523: 9522: 9520: 9519: 9514: 9509: 9504: 9499: 9494: 9489: 9484: 9479: 9474: 9469: 9464: 9459: 9454: 9449: 9444: 9439: 9434: 9429: 9424: 9419: 9414: 9408: 9406: 9400: 9399: 9397: 9396: 9391: 9386: 9381: 9376: 9371: 9366: 9361: 9356: 9351: 9349:Propylbarbital 9346: 9341: 9336: 9331: 9326: 9321: 9316: 9311: 9306: 9301: 9296: 9291: 9286: 9281: 9276: 9271: 9265: 9263: 9257: 9256: 9254: 9253: 9248: 9246:Methylpentynol 9243: 9238: 9233: 9228: 9223: 9217: 9215: 9206: 9202: 9197: 9196: 9180: 9179: 9172: 9165: 9157: 9148: 9147: 9144: 9143: 9142: 9141: 9138: 9127: 9121: 9115: 9114: 9111: 9110: 9108: 9107: 9102: 9097: 9092: 9087: 9082: 9077: 9072: 9067: 9062: 9057: 9052: 9047: 9042: 9037: 9032: 9027: 9021: 9019: 9015: 9014: 9012: 9011: 9001: 8983: 8972: 8970: 8960:Sympatholytics 8956: 8955: 8953: 8952: 8947: 8941: 8939: 8937:Antipsychotics 8933: 8932: 8930: 8929: 8924: 8919: 8914: 8909: 8888: 8873: 8858: 8843: 8828: 8812: 8810: 8804: 8803: 8801: 8800: 8795: 8790: 8785: 8779: 8777: 8763: 8755:Gabapentinoids 8751: 8750: 8748: 8747: 8741: 8739: 8733: 8732: 8730: 8729: 8724: 8719: 8714: 8709: 8699: 8689: 8677: 8672: 8667: 8662: 8657: 8652: 8647: 8642: 8637: 8632: 8627: 8622: 8617: 8612: 8607: 8602: 8597: 8592: 8587: 8582: 8577: 8565: 8563: 8546: 8540: 8539: 8537: 8536: 8531: 8526: 8520: 8518: 8506: 8500: 8499: 8487: 8486: 8479: 8472: 8464: 8455: 8454: 8451: 8450: 8449: 8448: 8445: 8434: 8428: 8422: 8421: 8418: 8417: 8414: 8413: 8411: 8410: 8405: 8400: 8395: 8390: 8385: 8380: 8375: 8370: 8365: 8359: 8357: 8353: 8352: 8350: 8349: 8344: 8339: 8334: 8329: 8317: 8315: 8306: 8302: 8301: 8298: 8297: 8295: 8294: 8288: 8286: 8280: 8279: 8277: 8276: 8271: 8266: 8261: 8249: 8242:Gabapentinoids 8234: 8229: 8214: 8212:Paramethadione 8209: 8197: 8195: 8189: 8188: 8186: 8185: 8180: 8175: 8170: 8165: 8153: 8148: 8143: 8131: 8126: 8111: 8106: 8101: 8086: 8081: 8076: 8064: 8062: 8053: 8045: 8044: 8041: 8040: 8038: 8037: 8020:GABAR agonists 8015: 8013: 8009: 8008: 8006: 8005: 8000: 7995: 7990: 7985:(and related): 7978: 7976: 7970: 7969: 7967: 7966: 7961: 7956: 7951: 7948:sodium bromide 7930: 7925: 7920: 7915: 7910: 7905: 7900: 7895: 7880: 7865: 7860: 7855: 7850: 7845: 7833: 7831: 7823: 7815: 7809: 7808: 7796: 7795: 7788: 7781: 7773: 7764: 7763: 7756: 7752: 7749: 7748: 7746: 7745: 7740: 7735: 7729: 7727: 7723: 7722: 7720: 7719: 7713: 7711: 7704: 7703: 7701: 7700: 7694: 7692: 7688: 7687: 7685: 7684: 7678: 7676: 7672: 7671: 7669: 7668: 7662: 7657: 7652: 7647: 7640: 7638: 7634: 7633: 7631: 7630: 7624: 7622: 7616: 7615: 7613: 7612: 7606: 7604: 7600: 7599: 7597: 7596: 7591: 7585: 7583: 7576: 7575: 7573: 7572: 7567: 7561: 7555: 7550: 7545: 7540: 7535: 7530: 7525: 7520: 7515: 7510: 7504: 7498: 7496: 7490: 7489: 7487: 7486: 7481: 7476: 7470: 7468: 7462: 7461: 7459: 7458: 7453: 7448: 7443: 7438: 7432: 7430: 7426: 7425: 7423: 7422: 7417: 7412: 7407: 7402: 7397: 7392: 7387: 7382: 7377: 7372: 7367: 7362: 7357: 7352: 7347: 7342: 7337: 7332: 7326: 7324: 7320: 7319: 7317: 7316: 7311: 7301: 7296: 7291: 7286: 7281: 7276: 7271: 7266: 7261: 7256: 7251: 7245: 7240: 7234: 7232: 7226: 7225: 7223: 7222: 7217: 7212: 7207: 7202: 7197: 7191: 7189: 7185: 7184: 7182: 7181: 7176: 7171: 7166: 7161: 7155: 7153: 7149: 7148: 7146: 7145: 7140: 7135: 7130: 7125: 7119: 7113: 7108: 7103: 7098: 7093: 7088: 7083: 7078: 7073: 7067: 7062: 7056: 7051: 7046: 7041: 7036: 7031: 7026: 7021: 7016: 7011: 7006: 7001: 6996: 6991: 6986: 6981: 6976: 6968: 6963: 6958: 6953: 6948: 6943: 6937: 6932: 6927: 6922: 6917: 6911: 6906: 6901: 6896: 6891: 6886: 6881: 6876: 6871: 6866: 6861: 6856: 6851: 6846: 6841: 6836: 6831: 6826: 6821: 6816: 6810: 6805: 6800: 6795: 6790: 6785: 6780: 6775: 6770: 6765: 6760: 6755: 6750: 6744: 6739: 6734: 6728: 6726: 6722: 6721: 6714: 6713: 6706: 6699: 6691: 6685: 6684: 6676: 6675:External links 6673: 6670: 6669: 6636: 6612: 6584: 6554: 6527: 6501: 6482:(3): 263–270. 6466: 6464: 6463: 6434: 6414:(5): 961–966. 6398:, which cites 6356: 6313: 6295: 6284:(2): 789–795. 6268: 6239:(7): 671–680. 6219: 6160: 6117: 6098:(2): 389–396. 6081: 6054:(3): 329–341. 6033: 6014:(4): 225–231. 5998: 5939: 5910:(6): 472–473. 5890: 5859:(3): 329–364. 5839: 5818:(3): 215–222. 5798: 5763: 5736: 5725:. benzo.org.uk 5713: 5706: 5694:(March 2007). 5679: 5648: 5599: 5580:(8): 827–844. 5560: 5526: 5519: 5499: 5492: 5472: 5457: 5450: 5433: 5384: 5357:(2): 126–136. 5341: 5315: 5293: 5261: 5226: 5215:. benzo.org.uk 5203: 5168: 5153: 5122: 5095:(5): 297–321. 5079: 5060:(6): 408–413. 5039: 5012:(6): 461–475. 4996: 4969:(5): 354–380. 4953: 4918: 4878: 4835: 4808:(2): 175–179. 4792: 4763:(1): 196–204. 4743: 4716:(5): 139–140. 4700: 4649: 4638:(6): 479–485. 4622: 4595:(5): 376–410. 4579: 4552:(4): 243–251. 4536: 4509:(3): 369–373. 4493: 4482:(4): 326–336. 4466: 4440: 4391: 4364:(2): 267–278. 4348: 4321:(3): 345–353. 4305: 4264: 4253:(3): 235–239. 4237: 4218:(4): 315–319. 4202: 4156: 4106: 4057: 4030: 3984: 3965:(7): 745–748. 3944: 3933:(9): 458–461. 3917: 3874: 3833: 3784: 3773:. benzo.org.uk 3752: 3723:(3): 706–714. 3703: 3678: 3649:(8): 575–581. 3629: 3579: 3536:(9): 951–975. 3516: 3489: 3466: 3432: 3389: 3340: 3288: 3261:(2): 175–179. 3245: 3226: 3202: 3167: 3160:. p. D6. 3142: 3117: 3087: 3059: 3040: 3029: 3007: 2993:. March 2007. 2972: 2953:(4): 259–267. 2934: 2872: 2828: 2798: 2779:(2): 397–403. 2762: 2719: 2684: 2625: 2614:. 27 June 2024 2599: 2573: 2562:. 7 April 2023 2547: 2521: 2510:. 9 March 2020 2495: 2469: 2435: 2424: 2395: 2384: 2364: 2353: 2334: 2315: 2295: 2264: 2263: 2261: 2258: 2244:agreed to pay 2237: 2234: 2217: 2214: 2183: 2180: 2178: 2175: 2122: 2119: 2097:benzyl alcohol 2070:benzyl alcohol 2054:indigo carmine 2017: 2014: 1986: 1982: 1978: 1974: 1967:GABA receptors 1962: 1959: 1926: 1923: 1902:anticonvulsant 1884:Lorazepam has 1881: 1878: 1861: 1858: 1835:gastric lavage 1804:hypnotic state 1765: 1762: 1708: 1705: 1650:benzodiazepine 1644: 1641: 1620: 1608: 1602: 1596:anticonvulsant 1571: 1568: 1567: 1566: 1557: 1551: 1536:kidney failure 1529: 1519: 1516: 1515: 1514: 1471: 1465: 1459: 1444: 1438: 1428: 1414: 1398: 1397: 1312: 1310: 1303: 1297: 1294: 1282: 1281: 1274: 1266: 1259: 1212:CNS depressant 1203: 1200: 1172: 1169: 1147: 1144: 1096: 1093: 1069:acute seizures 1061:anticonvulsant 1029: 1026: 1006: 1003: 1001: 998: 852:benzodiazepine 831: 830: 813: 812: 810: 809: 806: 804: 801: 793: 792: 791: 788: 787: 785: 784: 781: 773: 772: 771: 768: 767: 765: 764: 756: 754: 746: 745: 739: 733: 732: 729: 723: 717: 711: 705: 700: 694: 693: 689: 688: 678: 670: 669: 667: 666: 653: 651: 638: 637: 635: 634: 626: 624: 618: 617: 615: 614: 606: 604: 598: 597: 595: 594: 586: 584: 578: 577: 575: 574: 566: 564: 558: 557: 555: 554: 546: 544: 538: 537: 535: 534: 526: 524: 518: 517: 515: 514: 506: 504: 493: 492: 490: 489: 481: 479: 473: 472: 470: 469: 462: 454: 453: 452: 449: 448: 444: 443: 438: 432: 431: 428: 422: 421: 418: 409: 408: 405: 399: 398: 390: 384: 383: 380: 374: 373: 366: 365: 363: 362: 359: 344: 331: 319: 308: 295: 281: 279: 273: 272: 268: 267: 265: 264: 251: 249: 243: 242: 240:Benzodiazepine 237: 231: 230: 213: 211:administration 205: 204: 201: 193: 192: 189: 181: 180: 178: 177: 175: 165: 163: 155: 154: 152: 151: 133: 131: 125: 124: 117: 111: 110: 103: 93: 92: 89: 85: 84: 83:Ativan, others 81: 75: 74: 70: 69: 61: 60: 26: 9: 6: 4: 3: 2: 17523: 17512: 17509: 17507: 17504: 17502: 17499: 17497: 17494: 17492: 17489: 17487: 17484: 17482: 17479: 17477: 17474: 17472: 17469: 17467: 17464: 17462: 17459: 17457: 17454: 17453: 17451: 17441: 17431: 17430: 17427: 17416: 17415: 17411: 17408: 17402: 17391: 17387: 17386: 17384: 17379: 17373: 17366: 17362: 17361: 17359: 17354: 17348: 17345: 17341: 17327: 17324: 17322: 17319: 17317: 17314: 17312: 17311:Niflumic acid 17309: 17307: 17304: 17302: 17299: 17297: 17294: 17292: 17289: 17287: 17284: 17283: 17281: 17279: 17275: 17272: 17268: 17258: 17255: 17253: 17250: 17248: 17245: 17243: 17240: 17238: 17235: 17233: 17230: 17229: 17227: 17225: 17221: 17215: 17212: 17210: 17207: 17205: 17204:Glibenclamide 17202: 17201: 17199: 17197: 17193: 17190: 17185: 17179: 17169: 17166: 17165: 17163: 17161: 17157: 17151: 17150:Niflumic acid 17148: 17146: 17143: 17141: 17138: 17136: 17135:Glibenclamide 17133: 17131: 17128: 17126: 17123: 17121: 17118: 17116: 17113: 17111: 17108: 17106: 17103: 17102: 17100: 17098: 17094: 17091: 17086: 17080: 17077: 17075: 17071: 17057: 17054: 17052: 17049: 17047: 17044: 17042: 17039: 17037: 17034: 17033: 17031: 17029: 17025: 17022: 17017: 17011: 17001: 16998: 16997: 16995: 16993: 16989: 16983: 16980: 16978: 16975: 16973: 16970: 16969: 16967: 16965: 16961: 16958: 16953: 16947: 16937: 16934: 16932: 16931:Grayanotoxins 16929: 16927: 16924: 16922: 16921:Batrachotoxin 16919: 16916: 16912: 16908: 16907:ω-Atracotoxin 16904: 16902: 16899: 16898: 16896: 16894: 16890: 16884: 16881: 16879: 16876: 16873: 16869: 16866: 16864: 16861: 16859: 16858:Buprenorphine 16856: 16853: 16852: 16849: 16846: 16844: 16841: 16839: 16836: 16834: 16831: 16829: 16826: 16823: 16822: 16819: 16816: 16814: 16811: 16809: 16806: 16804: 16801: 16799: 16796: 16794: 16791: 16789: 16786: 16784: 16781: 16779: 16776: 16774: 16771: 16768: 16767: 16764: 16761: 16759: 16756: 16754: 16751: 16749: 16746: 16744: 16741: 16739: 16736: 16734: 16731: 16729: 16726: 16724: 16721: 16719: 16716: 16714: 16711: 16709: 16706: 16704: 16701: 16699: 16696: 16694: 16691: 16689: 16686: 16684: 16681: 16679: 16676: 16674: 16671: 16669: 16666: 16664: 16661: 16659: 16656: 16654: 16651: 16649: 16646: 16643: 16639: 16635: 16632: 16630: 16627: 16625: 16622: 16620: 16617: 16615: 16613: 16609: 16606: 16605: 16602: 16599: 16597: 16594: 16592: 16591:Valproic acid 16589: 16587: 16584: 16582: 16579: 16577: 16574: 16572: 16569: 16567: 16564: 16562: 16559: 16557: 16554: 16552: 16549: 16547: 16544: 16542: 16539: 16537: 16536:Oxitriptyline 16534: 16532: 16531:Oxcarbazepine 16529: 16527: 16524: 16522: 16521:Licarbazepine 16519: 16517: 16514: 16512: 16509: 16507: 16504: 16502: 16499: 16497: 16494: 16492: 16489: 16487: 16484: 16482: 16479: 16477: 16476:Carbamazepine 16474: 16472: 16469: 16466: 16465: 16462: 16459: 16457: 16454: 16452: 16449: 16447: 16444: 16442: 16439: 16437: 16434: 16432: 16429: 16427: 16424: 16422: 16419: 16417: 16414: 16412: 16409: 16407: 16404: 16402: 16399: 16397: 16394: 16392: 16389: 16387: 16384: 16382: 16379: 16377: 16374: 16371: 16370: 16367: 16364: 16363:Antianginals: 16361: 16360: 16358: 16356: 16352: 16349: 16344: 16338: 16335: 16333: 16329: 16315: 16312: 16311: 16309: 16307: 16303: 16297: 16296:Norfluoxetine 16294: 16292: 16289: 16287: 16284: 16282: 16279: 16278: 16276: 16274: 16270: 16267: 16262: 16256: 16246: 16243: 16241: 16238: 16236: 16233: 16231: 16230:Niflumic acid 16228: 16226: 16223: 16221: 16218: 16216: 16209: 16208: 16206: 16204: 16200: 16194: 16191: 16189: 16186: 16184: 16177: 16176: 16174: 16172: 16168: 16165: 16160: 16151: 16141: 16138: 16133: 16127: 16126: 16123: 16120: 16118: 16115: 16113: 16110: 16108: 16105: 16103: 16100: 16098: 16095: 16093: 16090: 16088: 16085: 16083: 16082:Levcromakalim 16080: 16078: 16075: 16073: 16070: 16068: 16065: 16063: 16060: 16058: 16055: 16050: 16041: 16040: 16038: 16036: 16032: 16026: 16023: 16021: 16018: 16016: 16013: 16011: 16008: 16006: 16003: 16001: 15998: 15996: 15993: 15991: 15988: 15986: 15983: 15978: 15972: 15971: 15968: 15965: 15963: 15960: 15958: 15955: 15953: 15950: 15948: 15945: 15943: 15940: 15938: 15935: 15933: 15930: 15928: 15925: 15923: 15920: 15918: 15915: 15913: 15910: 15908: 15905: 15903: 15900: 15898: 15895: 15893: 15890: 15888: 15885: 15883: 15880: 15878: 15877:Acetohexamide 15875: 15870: 15861: 15860: 15858: 15856: 15852: 15849: 15844: 15838: 15828: 15825: 15823: 15820: 15818: 15810: 15809: 15807: 15805: 15801: 15795: 15792: 15790: 15787: 15785: 15782: 15780: 15772: 15771: 15768: 15765: 15763: 15760: 15758: 15755: 15753: 15750: 15748: 15745: 15743: 15740: 15738: 15735: 15733: 15730: 15728: 15725: 15723: 15722:Roxithromycin 15720: 15718: 15715: 15713: 15710: 15708: 15705: 15703: 15700: 15698: 15695: 15693: 15690: 15688: 15685: 15683: 15680: 15678: 15675: 15673: 15670: 15668: 15665: 15663: 15660: 15658: 15655: 15653: 15650: 15648: 15645: 15643: 15640: 15638: 15635: 15633: 15630: 15628: 15625: 15623: 15620: 15618: 15615: 15613: 15610: 15608: 15605: 15603: 15600: 15598: 15595: 15593: 15590: 15588: 15585: 15583: 15580: 15578: 15575: 15573: 15570: 15568: 15565: 15559: 15555: 15554: 15551: 15548: 15546: 15543: 15541: 15538: 15536: 15533: 15531: 15528: 15526: 15523: 15521: 15518: 15516: 15513: 15511: 15508: 15506: 15503: 15501: 15498: 15496: 15493: 15491: 15488: 15486: 15483: 15481: 15478: 15476: 15473: 15471: 15468: 15466: 15463: 15461: 15458: 15456: 15453: 15451: 15448: 15446: 15443: 15441: 15438: 15436: 15433: 15431: 15428: 15426: 15423: 15421: 15418: 15416: 15415:Charybdotoxin 15413: 15411: 15408: 15406: 15403: 15401: 15398: 15396: 15393: 15391: 15388: 15386: 15383: 15381: 15378: 15376: 15373: 15372: 15370: 15368: 15364: 15361: 15356: 15350: 15347: 15345: 15341: 15327: 15324: 15322: 15318: 15317: 15315: 15313: 15309: 15303: 15300: 15298: 15297:Trimethadione 15295: 15293: 15290: 15288: 15285: 15283: 15280: 15278: 15275: 15273: 15270: 15268: 15265: 15263: 15260: 15258: 15255: 15253: 15250: 15248: 15245: 15243: 15240: 15238: 15235: 15233: 15230: 15228: 15225: 15223: 15220: 15218: 15215: 15213: 15210: 15208: 15205: 15203: 15200: 15198: 15195: 15193: 15190: 15188: 15185: 15183: 15180: 15178: 15175: 15173: 15170: 15168: 15165: 15163: 15160: 15158: 15155: 15153: 15150: 15148: 15145: 15143: 15140: 15138: 15137:Diproteverine 15135: 15133: 15130: 15128: 15125: 15123: 15120: 15118: 15115: 15113: 15110: 15108: 15105: 15103: 15100: 15098: 15095: 15092: 15091: 15088: 15085: 15083: 15080: 15078: 15075: 15073: 15070: 15068: 15065: 15063: 15060: 15058: 15055: 15053: 15050: 15048: 15045: 15043: 15040: 15038: 15035: 15033: 15030: 15028: 15025: 15023: 15020: 15018: 15014: 15006: 15005: 15002: 14999: 14997: 14996:Ruthenium red 14994: 14992: 14989: 14987: 14984: 14982: 14979: 14977: 14974: 14972: 14971:Levetiracetam 14969: 14967: 14964: 14962: 14959: 14957: 14954: 14952: 14949: 14947: 14944: 14942: 14939: 14937: 14934: 14932: 14929: 14927: 14924: 14922: 14921:ω-Agatoxin TK 14919: 14916: 14915: 14912: 14909: 14907: 14904: 14902: 14899: 14897: 14894: 14892: 14891:Niflumic acid 14889: 14887: 14884: 14882: 14879: 14877: 14873: 14872: 14869: 14866: 14864: 14860: 14859: 14856: 14853: 14851: 14848: 14846: 14842: 14841: 14838: 14835: 14833: 14830: 14828: 14825: 14823: 14820: 14818: 14815: 14813: 14810: 14808: 14805: 14803: 14800: 14798: 14795: 14793: 14790: 14788: 14784: 14783: 14780: 14777: 14775: 14772: 14770: 14767: 14765: 14762: 14760: 14757: 14755: 14752: 14750: 14747: 14745: 14742: 14740: 14737: 14733: 14730: 14728: 14725: 14723: 14720: 14718: 14715: 14713: 14710: 14708: 14705: 14703: 14700: 14698: 14695: 14693: 14690: 14688: 14685: 14683: 14680: 14678: 14675: 14673: 14670: 14668: 14665: 14663: 14658: 14655: 14653: 14650: 14648: 14645: 14643: 14640: 14638: 14635: 14633: 14628: 14625: 14623: 14620: 14618: 14615: 14613: 14610: 14608: 14605: 14603: 14600: 14598: 14595: 14593: 14590: 14588: 14585: 14583: 14580: 14578: 14575: 14573: 14570: 14568: 14565: 14563: 14560: 14558: 14555: 14553: 14550: 14548: 14545: 14543: 14540: 14538: 14535: 14533: 14530: 14528: 14525: 14523: 14520: 14518: 14515: 14513: 14512:Levamlodipine 14510: 14508: 14507:Lercanidipine 14505: 14503: 14500: 14498: 14495: 14493: 14490: 14488: 14485: 14483: 14480: 14478: 14475: 14473: 14470: 14468: 14465: 14463: 14460: 14458: 14455: 14453: 14450: 14448: 14445: 14443: 14440: 14438: 14435: 14433: 14430: 14428: 14425: 14423: 14420: 14418: 14414: 14412: 14408: 14407: 14405: 14403: 14399: 14396: 14391: 14385: 14382: 14380: 14376: 14372: 14365: 14360: 14358: 14353: 14351: 14346: 14345: 14342: 14332: 14331: 14327: 14323: 14320: 14314: 14308: 14305: 14303: 14300: 14298: 14295: 14293: 14290: 14287: 14286: 14282: 14278: 14274: 14273:isovaleramide 14270: 14266: 14263: 14261: 14258: 14255: 14251: 14248: 14245: 14241: 14237: 14233: 14230: 14228: 14225: 14223: 14220: 14218: 14215: 14213: 14210: 14208: 14205: 14203: 14200: 14198: 14195: 14193: 14190: 14188: 14185: 14183: 14180: 14178: 14175: 14173: 14170: 14167: 14163: 14159: 14155: 14151: 14148: 14146: 14143: 14141: 14138: 14136: 14133: 14131: 14128: 14126: 14123: 14121: 14118: 14115: 14111: 14110:niflumic acid 14107: 14103: 14099: 14096: 14094: 14091: 14089: 14086: 14084: 14081: 14079: 14076: 14073: 14069: 14065: 14061: 14057: 14054: 14052: 14049: 14047: 14044: 14042: 14039: 14037: 14036:Clomethiazole 14034: 14032: 14031:Chlormezanone 14029: 14027: 14024: 14022: 14021:Carbamazepine 14019: 14016: 14012: 14008: 14004: 14001: 13998: 13994: 13991: 13989: 13986: 13984: 13981: 13979: 13976: 13974: 13971: 13970: 13968: 13964: 13958: 13955: 13953: 13950: 13948: 13945: 13943: 13940: 13938: 13935: 13933: 13930: 13928: 13925: 13923: 13920: 13918: 13915: 13913: 13910: 13908: 13905: 13903: 13900: 13898: 13897:Nitrous oxide 13895: 13893: 13890: 13888: 13885: 13883: 13880: 13878: 13875: 13873: 13870: 13868: 13865: 13863: 13860: 13858: 13855: 13853: 13850: 13848: 13845: 13843: 13840: 13838: 13835: 13833: 13830: 13828: 13827:Diethyl ether 13825: 13823: 13820: 13818: 13815: 13813: 13810: 13808: 13805: 13803: 13800: 13798: 13795: 13793: 13790: 13788: 13785: 13783: 13780: 13778: 13775: 13773: 13770: 13768: 13765: 13763: 13760: 13758: 13755: 13753: 13750: 13748: 13745: 13744: 13742: 13740: 13736: 13732: 13726: 13723: 13721: 13718: 13716: 13713: 13711: 13708: 13706: 13703: 13701: 13698: 13696: 13693: 13691: 13688: 13686: 13683: 13681: 13678: 13677: 13675: 13673: 13669: 13663: 13660: 13658: 13655: 13653: 13650: 13648: 13645: 13644: 13642: 13640: 13636: 13630: 13629:Pyrithyldione 13627: 13625: 13622: 13620: 13617: 13615: 13612: 13611: 13609: 13607: 13603: 13597: 13594: 13592: 13589: 13587: 13584: 13583: 13581: 13579: 13575: 13569: 13566: 13564: 13561: 13559: 13556: 13554: 13551: 13549: 13546: 13544: 13541: 13539: 13536: 13534: 13531: 13529: 13526: 13524: 13521: 13519: 13516: 13514: 13511: 13509: 13506: 13504: 13501: 13499: 13496: 13494: 13491: 13489: 13486: 13484: 13481: 13479: 13476: 13474: 13471: 13469: 13466: 13464: 13461: 13459: 13456: 13454: 13451: 13449: 13446: 13444: 13441: 13439: 13436: 13434: 13431: 13429: 13426: 13424: 13420: 13417: 13416: 13413: 13410: 13408: 13405: 13403: 13400: 13398: 13395: 13393: 13390: 13388: 13385: 13383: 13380: 13378: 13374: 13373: 13369: 13368: 13365: 13362: 13360: 13357: 13355: 13352: 13350: 13347: 13345: 13341: 13340: 13336: 13335: 13332: 13329: 13327: 13324: 13322: 13319: 13317: 13314: 13312: 13309: 13307: 13303: 13302: 13298: 13297: 13295: 13293: 13289: 13283: 13280: 13278: 13275: 13273: 13270: 13268: 13265: 13263: 13260: 13258: 13255: 13253: 13250: 13248: 13245: 13243: 13240: 13238: 13235: 13233: 13230: 13228: 13225: 13223: 13220: 13218: 13215: 13213: 13210: 13208: 13205: 13203: 13200: 13198: 13195: 13193: 13190: 13188: 13185: 13183: 13180: 13178: 13175: 13173: 13170: 13168: 13165: 13163: 13160: 13158: 13154: 13152: 13149: 13147: 13144: 13142: 13139: 13137: 13134: 13132: 13129: 13127: 13124: 13122: 13119: 13118: 13116: 13114: 13110: 13104: 13101: 13099: 13096: 13094: 13091: 13089: 13086: 13084: 13081: 13079: 13076: 13075: 13073: 13071: 13067: 13061: 13058: 13056: 13053: 13051: 13048: 13046: 13043: 13041: 13038: 13036: 13033: 13031: 13028: 13026: 13023: 13021: 13018: 13016: 13013: 13011: 13008: 13006: 13003: 13001: 12998: 12996: 12993: 12991: 12988: 12987: 12985: 12982: 12978: 12972: 12969: 12967: 12964: 12962: 12959: 12958: 12956: 12954: 12950: 12944: 12941: 12938: 12934: 12931: 12929: 12926: 12924: 12921: 12919: 12916: 12914: 12911: 12909: 12906: 12904: 12901: 12899: 12896: 12894: 12891: 12889: 12886: 12884: 12881: 12879: 12876: 12874: 12871: 12870: 12868: 12866: 12862: 12856: 12853: 12851: 12848: 12846: 12843: 12841: 12838: 12836: 12835:Phenprobamate 12833: 12831: 12828: 12826: 12823: 12821: 12818: 12816: 12813: 12811: 12808: 12806: 12803: 12801: 12800:Hexapropymate 12798: 12796: 12793: 12791: 12788: 12786: 12783: 12781: 12778: 12776: 12775:Difebarbamate 12773: 12771: 12768: 12766: 12763: 12761: 12758: 12756: 12753: 12752: 12750: 12748: 12744: 12738: 12735: 12733: 12730: 12728: 12725: 12723: 12720: 12718: 12715: 12713: 12710: 12708: 12705: 12703: 12700: 12698: 12695: 12693: 12690: 12688: 12685: 12683: 12680: 12678: 12675: 12673: 12670: 12668: 12665: 12663: 12660: 12658: 12655: 12653: 12650: 12648: 12645: 12643: 12640: 12638: 12635: 12633: 12630: 12628: 12625: 12623: 12620: 12618: 12615: 12613: 12610: 12608: 12605: 12603: 12600: 12598: 12595: 12593: 12590: 12588: 12587:Nortetrazepam 12585: 12583: 12580: 12578: 12575: 12573: 12570: 12568: 12565: 12563: 12560: 12558: 12555: 12553: 12550: 12548: 12545: 12543: 12540: 12538: 12535: 12533: 12530: 12528: 12525: 12523: 12520: 12518: 12515: 12513: 12510: 12508: 12505: 12503: 12500: 12498: 12495: 12493: 12490: 12488: 12485: 12483: 12480: 12478: 12475: 12473: 12470: 12468: 12465: 12463: 12460: 12458: 12455: 12453: 12450: 12448: 12447:Flutoprazepam 12445: 12443: 12440: 12438: 12435: 12433: 12430: 12428: 12427:Flunitrazolam 12425: 12423: 12422:Flunitrazepam 12420: 12418: 12415: 12413: 12412:Flubromazolam 12410: 12408: 12407:Flubromazepam 12405: 12403: 12400: 12398: 12395: 12393: 12390: 12388: 12385: 12383: 12380: 12378: 12375: 12373: 12370: 12368: 12365: 12363: 12360: 12358: 12355: 12353: 12350: 12348: 12345: 12343: 12340: 12338: 12335: 12333: 12330: 12328: 12325: 12323: 12320: 12318: 12315: 12313: 12310: 12308: 12307:Cloniprazepam 12305: 12303: 12300: 12298: 12295: 12293: 12290: 12288: 12285: 12283: 12280: 12278: 12275: 12273: 12270: 12268: 12265: 12263: 12260: 12258: 12255: 12253: 12250: 12248: 12245: 12243: 12240: 12238: 12235: 12233: 12230: 12228: 12225: 12223: 12220: 12218: 12215: 12213: 12210: 12208: 12205: 12203: 12200: 12198: 12197:2-Oxoquazepam 12195: 12194: 12192: 12190: 12186: 12180: 12177: 12175: 12172: 12170: 12167: 12165: 12162: 12160: 12157: 12155: 12152: 12150: 12147: 12145: 12142: 12140: 12139:Thialbarbital 12137: 12135: 12134:Tetrabarbital 12132: 12130: 12127: 12125: 12122: 12120: 12119:Spirobarbital 12117: 12115: 12112: 12110: 12107: 12105: 12102: 12100: 12099:Proxibarbital 12097: 12095: 12092: 12090: 12089:Propallylonal 12087: 12085: 12082: 12080: 12077: 12075: 12072: 12070: 12069:Phenobarbital 12067: 12065: 12062: 12060: 12059:Pentobarbital 12057: 12055: 12052: 12050: 12049:Narcobarbital 12047: 12045: 12042: 12040: 12037: 12035: 12032: 12030: 12027: 12025: 12022: 12020: 12017: 12015: 12014:Heptobarbital 12012: 12010: 12007: 12005: 12002: 12000: 11997: 11995: 11992: 11990: 11987: 11985: 11984:Difebarbamate 11982: 11980: 11977: 11975: 11974:Cyclobarbital 11972: 11970: 11967: 11965: 11962: 11960: 11957: 11955: 11952: 11950: 11947: 11945: 11942: 11940: 11937: 11935: 11932: 11930: 11927: 11925: 11922: 11920: 11919:Benzobarbital 11917: 11915: 11912: 11910: 11907: 11905: 11902: 11900: 11897: 11895: 11892: 11890: 11887: 11885: 11882: 11881: 11879: 11877: 11873: 11867: 11864: 11862: 11859: 11857: 11854: 11852: 11849: 11847: 11845: 11841: 11839: 11837: 11833: 11831: 11828: 11826: 11823: 11821: 11818: 11816: 11813: 11811: 11808: 11806: 11803: 11801: 11798: 11796: 11793: 11791: 11790:Ethchlorvynol 11788: 11785: 11781: 11778: 11776: 11773: 11771: 11768: 11766: 11763: 11761: 11758: 11757: 11755: 11753: 11749: 11745: 11732: 11727: 11725: 11720: 11718: 11713: 11712: 11709: 11697: 11694: 11692: 11689: 11687: 11684: 11682: 11681:Dexamethasone 11679: 11677: 11674: 11672: 11669: 11668: 11666: 11662: 11656: 11653: 11651: 11648: 11646: 11643: 11641: 11640:Fosaprepitant 11638: 11636: 11633: 11632: 11630: 11628: 11620: 11614: 11611: 11609: 11606: 11603: 11600: 11598: 11595: 11593: 11590: 11589: 11587: 11584: 11579: 11576: 11572: 11566: 11563: 11561: 11558: 11556: 11553: 11551: 11548: 11546: 11543: 11541: 11538: 11537: 11535: 11532: 11527: 11519: 11513: 11510: 11508: 11505: 11503: 11500: 11498: 11495: 11493: 11490: 11488: 11485: 11483: 11480: 11478: 11475: 11474: 11472: 11470: 11458: 11451: 11447: 11444: 11442: 11439: 11437: 11434: 11433: 11431: 11428: 11423: 11420: 11413: 11407: 11404: 11402: 11399: 11397: 11394: 11392: 11389: 11387: 11384: 11382: 11379: 11378: 11376: 11374: 11368: 11362: 11359: 11357: 11354: 11352: 11349: 11347: 11344: 11342: 11339: 11336: 11332: 11329: 11327: 11324: 11322: 11319: 11317: 11314: 11312: 11309: 11307: 11304: 11302: 11299: 11297: 11294: 11292: 11289: 11287: 11284: 11282: 11279: 11277: 11274: 11272: 11269: 11267: 11264: 11263: 11261: 11259: 11256:serotonin ion 11249: 11244: 11240: 11233: 11228: 11226: 11221: 11219: 11214: 11213: 11210: 11194: 11192: 11189: 11188: 11186: 11183: 11180: 11177: 11175: 11172: 11171: 11167: 11157: 11154: 11152: 11149: 11148: 11146: 11142: 11136: 11133: 11131: 11128: 11126: 11123: 11122: 11120: 11118: 11114: 11108: 11105: 11103: 11102:Phencyclidine 11100: 11098: 11095: 11093: 11090: 11089: 11087: 11085: 11081: 11075: 11072: 11069: 11066: 11064: 11063:Phenoperidine 11061: 11059: 11056: 11054: 11051: 11049: 11046: 11044: 11041: 11039: 11036: 11034: 11031: 11030: 11028: 11026: 11022: 11016: 11013: 11011: 11008: 11006: 11003: 11001: 10998: 10997: 10995: 10993: 10989: 10983: 10980: 10978: 10975: 10973: 10970: 10968: 10967:Narcobarbital 10965: 10963: 10960: 10958: 10955: 10953: 10950: 10949: 10947: 10945: 10941: 10935: 10932: 10930: 10927: 10925: 10922: 10921: 10919: 10917: 10913: 10910: 10908: 10904: 10898: 10895: 10893: 10890: 10888: 10885: 10883: 10880: 10878: 10877:Nitrous oxide 10875: 10873: 10870: 10868: 10865: 10863: 10860: 10858: 10855: 10853: 10850: 10848: 10845: 10843: 10840: 10838: 10837:Diethyl ether 10835: 10833: 10830: 10828: 10825: 10823: 10820: 10819: 10817: 10815: 10811: 10806: 10802: 10795: 10790: 10788: 10783: 10781: 10776: 10775: 10772: 10760: 10757: 10755: 10752: 10750: 10747: 10745: 10742: 10740: 10737: 10734: 10730: 10727: 10725: 10722: 10718: 10717:Methocarbamol 10715: 10713: 10710: 10708: 10707:Mephenoxalone 10705: 10703: 10700: 10698: 10697:Chlorphenesin 10695: 10694: 10693: 10689: 10686: 10684: 10681: 10679: 10676: 10674: 10671: 10667: 10666:Phenaglycodol 10664: 10662: 10659: 10657: 10654: 10653: 10652: 10649: 10645: 10642: 10641: 10640: 10637: 10636: 10634: 10630: 10624: 10621: 10619: 10616: 10614: 10611: 10609: 10606: 10604: 10601: 10600: 10598: 10596: 10583: 10577: 10574: 10572: 10569: 10567: 10564: 10563: 10561: 10559: 10555: 10549: 10546: 10544: 10541: 10539: 10536: 10534: 10531: 10530: 10528: 10526: 10522: 10512: 10509: 10508: 10506: 10502: 10493: 10490: 10488: 10485: 10483: 10480: 10479: 10478: 10475: 10470: 10467: 10465: 10462: 10461: 10460: 10457: 10456: 10454: 10452: 10448: 10439: 10436: 10434: 10431: 10430: 10429: 10426: 10421: 10418: 10416: 10413: 10411: 10410:Amitriptyline 10408: 10407: 10406: 10403: 10401: 10398: 10397: 10395: 10393: 10389: 10386: 10384: 10377: 10371: 10368: 10366: 10363: 10361: 10358: 10356: 10353: 10351: 10348: 10346: 10343: 10341: 10338: 10336: 10333: 10332: 10330: 10328: 10320: 10307: 10304: 10302: 10299: 10297: 10294: 10293: 10292: 10289: 10284: 10281: 10279: 10276: 10275: 10274: 10271: 10270: 10268: 10266: 10262: 10253: 10250: 10248: 10245: 10244: 10243: 10240: 10235: 10232: 10230: 10227: 10225: 10224:Amitriptyline 10222: 10221: 10220: 10217: 10213: 10210: 10208: 10205: 10203: 10200: 10199: 10198: 10195: 10194: 10192: 10190: 10186: 10180: 10177: 10175: 10172: 10170: 10167: 10165: 10162: 10160: 10159:Methapyrilene 10157: 10155: 10152: 10150: 10147: 10145: 10142: 10140: 10137: 10135: 10132: 10131: 10129: 10127: 10123: 10120: 10118: 10111: 10105: 10102: 10100: 10097: 10095: 10092: 10090: 10087: 10084: 10080: 10077: 10075: 10072: 10070: 10067: 10065: 10064:Aceburic acid 10062: 10060: 10057: 10055: 10052: 10051: 10049: 10047: 10040: 10028: 10025: 10023: 10020: 10018: 10017:Isovaleramide 10015: 10014: 10013: 10012:Sesquiterpene 10010: 10008: 10005: 10001: 9998: 9996: 9993: 9991: 9988: 9987: 9986: 9983: 9981: 9978: 9976: 9973: 9971: 9968: 9966: 9963: 9961: 9958: 9956: 9953: 9951: 9950:Clomethiazole 9948: 9946: 9943: 9941: 9938: 9936: 9933: 9931: 9928: 9924: 9921: 9919: 9916: 9914: 9911: 9910: 9908: 9905: 9903: 9900: 9898: 9895: 9894: 9892: 9888: 9882: 9879: 9877: 9874: 9872: 9869: 9867: 9864: 9862: 9859: 9857: 9854: 9852: 9849: 9847: 9844: 9842: 9839: 9837: 9834: 9833: 9831: 9829: 9825: 9819: 9816: 9814: 9813:Pyrithyldione 9811: 9809: 9806: 9804: 9801: 9800: 9798: 9796: 9792: 9786: 9783: 9782: 9780: 9778: 9774: 9768: 9765: 9763: 9760: 9758: 9755: 9753: 9750: 9748: 9745: 9743: 9740: 9738: 9735: 9733: 9730: 9728: 9725: 9723: 9720: 9718: 9715: 9714: 9712: 9710: 9706: 9700: 9697: 9695: 9692: 9690: 9687: 9685: 9682: 9680: 9677: 9675: 9672: 9670: 9667: 9665: 9662: 9661: 9659: 9657: 9653: 9647: 9644: 9642: 9639: 9637: 9634: 9632: 9629: 9627: 9624: 9622: 9619: 9618: 9616: 9614: 9610: 9604: 9601: 9599: 9596: 9594: 9591: 9590: 9588: 9586: 9582: 9576: 9573: 9571: 9568: 9566: 9565:Phenprobamate 9563: 9561: 9560:Methocarbamol 9558: 9556: 9553: 9551: 9550:Hexapropymate 9548: 9546: 9543: 9541: 9538: 9536: 9533: 9532: 9530: 9528: 9524: 9518: 9515: 9513: 9510: 9508: 9505: 9503: 9500: 9498: 9495: 9493: 9490: 9488: 9485: 9483: 9480: 9478: 9475: 9473: 9470: 9468: 9467:Flutoprazepam 9465: 9463: 9460: 9458: 9455: 9453: 9452:Flunitrazepam 9450: 9448: 9447:Flunitrazolam 9445: 9443: 9442:Flubromazolam 9440: 9438: 9435: 9433: 9430: 9428: 9425: 9423: 9420: 9418: 9415: 9413: 9410: 9409: 9407: 9405: 9401: 9395: 9392: 9390: 9387: 9385: 9382: 9380: 9377: 9375: 9372: 9370: 9367: 9365: 9362: 9360: 9357: 9355: 9352: 9350: 9347: 9345: 9344:Phenobarbital 9342: 9340: 9337: 9335: 9334:Pentobarbital 9332: 9330: 9329:Narcobarbital 9327: 9325: 9322: 9320: 9319:Mephobarbital 9317: 9315: 9312: 9310: 9307: 9305: 9302: 9300: 9299:Cyclobarbital 9297: 9295: 9292: 9290: 9287: 9285: 9282: 9280: 9277: 9275: 9272: 9270: 9267: 9266: 9264: 9262: 9258: 9252: 9249: 9247: 9244: 9242: 9241:Ethchlorvynol 9239: 9237: 9234: 9232: 9229: 9227: 9224: 9222: 9219: 9218: 9216: 9214: 9210: 9207: 9205: 9198: 9193: 9189: 9185: 9178: 9173: 9171: 9166: 9164: 9159: 9158: 9155: 9139: 9137: 9134: 9133: 9131: 9128: 9125: 9122: 9120: 9117: 9116: 9112: 9106: 9103: 9101: 9098: 9096: 9093: 9091: 9088: 9086: 9083: 9081: 9078: 9076: 9075:Phenaglycodol 9073: 9071: 9068: 9066: 9063: 9061: 9058: 9056: 9053: 9051: 9048: 9046: 9043: 9041: 9038: 9036: 9033: 9031: 9028: 9026: 9023: 9022: 9020: 9016: 9009: 9005: 9004:Beta blockers 9002: 8999: 8995: 8991: 8987: 8984: 8981: 8977: 8974: 8973: 8971: 8967: 8961: 8957: 8951: 8948: 8946: 8943: 8942: 8940: 8938: 8934: 8928: 8925: 8923: 8920: 8918: 8915: 8913: 8910: 8908: 8905: 8901: 8894: 8889: 8886: 8879: 8874: 8871: 8864: 8859: 8856: 8849: 8844: 8841: 8834: 8829: 8826: 8819: 8814: 8813: 8811: 8809: 8805: 8799: 8796: 8794: 8791: 8789: 8786: 8784: 8781: 8780: 8778: 8774: 8771: 8756: 8752: 8746: 8743: 8742: 8740: 8738: 8734: 8728: 8725: 8723: 8720: 8718: 8717:Chlormezanone 8715: 8713: 8710: 8707: 8703: 8700: 8697: 8696:phenobarbital 8693: 8690: 8688: 8685: 8681: 8678: 8676: 8673: 8671: 8668: 8666: 8663: 8661: 8658: 8656: 8653: 8651: 8648: 8646: 8643: 8641: 8638: 8636: 8633: 8631: 8628: 8626: 8623: 8621: 8618: 8616: 8613: 8611: 8608: 8606: 8603: 8601: 8598: 8596: 8593: 8591: 8588: 8586: 8583: 8581: 8578: 8576: 8573: 8571: 8567: 8566: 8564: 8559: 8551: 8541: 8535: 8532: 8530: 8527: 8525: 8522: 8521: 8519: 8517: 8511: 8501: 8496: 8492: 8485: 8480: 8478: 8473: 8471: 8466: 8465: 8462: 8446: 8444: 8441: 8440: 8438: 8435: 8432: 8429: 8427: 8424: 8423: 8419: 8409: 8406: 8404: 8403:Levetiracetam 8401: 8399: 8396: 8394: 8391: 8389: 8386: 8384: 8381: 8379: 8376: 8374: 8371: 8369: 8366: 8364: 8361: 8360: 8358: 8354: 8348: 8345: 8343: 8340: 8338: 8335: 8333: 8332:Ethoxzolamide 8330: 8328: 8327:Acetazolamide 8325: 8323: 8319: 8318: 8316: 8314: 8313:CA inhibitors 8310: 8307: 8303: 8293: 8290: 8289: 8287: 8285: 8281: 8275: 8272: 8270: 8267: 8265: 8262: 8260: 8257: 8253: 8250: 8248: 8245: 8243: 8238: 8235: 8233: 8230: 8228: 8224: 8223: 8218: 8217:Trimethadione 8215: 8213: 8210: 8208: 8205: 8203: 8199: 8198: 8196: 8194: 8190: 8184: 8181: 8179: 8176: 8174: 8171: 8169: 8166: 8164: 8161: 8157: 8156:Oxcarbazepine 8154: 8152: 8149: 8147: 8146:Carbamazepine 8144: 8142: 8140: 8135: 8132: 8130: 8127: 8125: 8122: 8120: 8115: 8112: 8110: 8107: 8105: 8102: 8100: 8097: 8095: 8090: 8087: 8085: 8082: 8080: 8077: 8075: 8072: 8070: 8066: 8065: 8063: 8061: 8057: 8054: 8052: 8046: 8036: 8033: 8031: 8026: 8022: 8021: 8017: 8016: 8014: 8010: 8004: 8001: 7999: 7996: 7994: 7991: 7989: 7986: 7984: 7980: 7979: 7977: 7975: 7971: 7965: 7962: 7960: 7957: 7955: 7952: 7949: 7945: 7941: 7938: 7934: 7931: 7929: 7926: 7924: 7921: 7919: 7916: 7914: 7911: 7909: 7906: 7904: 7901: 7899: 7896: 7894: 7890: 7889: 7884: 7881: 7879: 7875: 7874: 7869: 7866: 7864: 7863:Phenobarbital 7861: 7859: 7858:Pentobarbital 7856: 7854: 7851: 7849: 7846: 7844: 7841: 7839: 7835: 7834: 7832: 7830: 7827: 7819: 7816: 7814: 7810: 7805: 7801: 7794: 7789: 7787: 7782: 7780: 7775: 7774: 7771: 7760: 7750: 7744: 7741: 7739: 7736: 7734: 7731: 7730: 7728: 7724: 7718: 7715: 7714: 7712: 7709: 7705: 7699: 7696: 7695: 7693: 7689: 7683: 7680: 7679: 7677: 7673: 7666: 7663: 7661: 7658: 7656: 7653: 7651: 7648: 7645: 7642: 7641: 7639: 7635: 7629: 7626: 7625: 7623: 7621: 7617: 7611: 7608: 7607: 7605: 7601: 7595: 7592: 7590: 7587: 7586: 7584: 7581: 7577: 7571: 7568: 7565: 7562: 7559: 7556: 7554: 7551: 7549: 7548:Fluclotizolam 7546: 7544: 7543:Flubrotizolam 7541: 7539: 7536: 7534: 7531: 7529: 7526: 7524: 7521: 7519: 7516: 7514: 7511: 7508: 7505: 7503: 7500: 7499: 7497: 7495: 7491: 7485: 7482: 7480: 7477: 7475: 7472: 7471: 7469: 7467: 7463: 7457: 7454: 7452: 7449: 7447: 7444: 7442: 7439: 7437: 7434: 7433: 7431: 7427: 7421: 7418: 7416: 7413: 7411: 7408: 7406: 7403: 7401: 7398: 7396: 7393: 7391: 7388: 7386: 7383: 7381: 7378: 7376: 7373: 7371: 7368: 7366: 7363: 7361: 7358: 7356: 7353: 7351: 7348: 7346: 7343: 7341: 7338: 7336: 7333: 7331: 7328: 7327: 7325: 7321: 7315: 7312: 7309: 7305: 7302: 7300: 7297: 7295: 7292: 7290: 7287: 7285: 7284:Flunitrazolam 7282: 7280: 7279:Flubromazolam 7277: 7275: 7274:Flualprazolam 7272: 7270: 7269:Fluadinazolam 7267: 7265: 7262: 7260: 7257: 7255: 7252: 7249: 7246: 7244: 7241: 7239: 7236: 7235: 7233: 7231: 7227: 7221: 7218: 7216: 7213: 7211: 7208: 7206: 7203: 7201: 7198: 7196: 7193: 7192: 7190: 7186: 7180: 7177: 7175: 7172: 7170: 7167: 7165: 7162: 7160: 7157: 7156: 7154: 7150: 7144: 7141: 7139: 7136: 7134: 7131: 7129: 7126: 7123: 7120: 7117: 7114: 7112: 7109: 7107: 7104: 7102: 7099: 7097: 7094: 7092: 7089: 7087: 7084: 7082: 7079: 7077: 7074: 7071: 7068: 7066: 7063: 7060: 7057: 7055: 7052: 7050: 7047: 7045: 7042: 7040: 7037: 7035: 7032: 7030: 7027: 7025: 7022: 7020: 7017: 7015: 7012: 7010: 7009:Nortetrazepam 7007: 7005: 7002: 7000: 6997: 6995: 6992: 6990: 6987: 6985: 6982: 6980: 6977: 6975: 6973: 6969: 6967: 6964: 6962: 6959: 6957: 6954: 6952: 6949: 6947: 6944: 6941: 6938: 6936: 6933: 6931: 6928: 6926: 6923: 6921: 6918: 6915: 6912: 6910: 6907: 6905: 6902: 6900: 6897: 6895: 6892: 6890: 6889:Flutoprazepam 6887: 6885: 6882: 6880: 6877: 6875: 6874:Flunitrazepam 6872: 6870: 6867: 6865: 6862: 6860: 6859:Flubromazepam 6857: 6855: 6852: 6850: 6847: 6845: 6842: 6840: 6837: 6835: 6832: 6830: 6829:Difludiazepam 6827: 6825: 6822: 6820: 6817: 6814: 6811: 6809: 6806: 6804: 6801: 6799: 6796: 6794: 6791: 6789: 6786: 6784: 6783:Cloniprazepam 6781: 6779: 6776: 6774: 6771: 6769: 6766: 6764: 6761: 6759: 6756: 6754: 6751: 6748: 6745: 6743: 6740: 6738: 6735: 6733: 6732:2-Oxoquazepam 6730: 6729: 6727: 6723: 6719: 6712: 6707: 6705: 6700: 6698: 6693: 6692: 6689: 6682: 6679: 6678: 6657: 6653: 6652: 6647: 6640: 6629: 6622: 6616: 6605: 6601: 6594: 6588: 6572: 6568: 6564: 6558: 6550: 6546: 6542: 6538: 6531: 6515: 6511: 6505: 6497: 6493: 6489: 6485: 6481: 6477: 6470: 6460: 6456: 6452: 6448: 6444: 6440: 6435: 6431: 6427: 6422: 6417: 6413: 6409: 6405: 6400: 6399: 6388: 6384: 6380: 6379: 6375: 6370: 6366: 6360: 6352: 6348: 6344: 6340: 6336: 6332: 6328: 6324: 6317: 6311: 6307: 6304: 6299: 6291: 6287: 6283: 6279: 6272: 6264: 6260: 6256: 6252: 6247: 6242: 6238: 6234: 6230: 6223: 6215: 6211: 6206: 6201: 6196: 6191: 6187: 6183: 6179: 6175: 6171: 6164: 6156: 6152: 6148: 6144: 6140: 6136: 6132: 6128: 6121: 6113: 6109: 6105: 6101: 6097: 6093: 6085: 6077: 6073: 6069: 6065: 6061: 6057: 6053: 6049: 6042: 6040: 6038: 6029: 6025: 6021: 6017: 6013: 6009: 6002: 5991: 5987: 5983: 5979: 5975: 5970: 5965: 5961: 5957: 5950: 5943: 5935: 5931: 5926: 5921: 5917: 5913: 5909: 5905: 5901: 5894: 5886: 5882: 5878: 5874: 5870: 5866: 5862: 5858: 5854: 5850: 5843: 5835: 5831: 5826: 5821: 5817: 5813: 5809: 5802: 5786: 5782: 5776: 5774: 5772: 5770: 5768: 5751: 5747: 5740: 5724: 5717: 5709: 5703: 5699: 5698: 5693: 5689: 5683: 5675: 5671: 5667: 5663: 5659: 5652: 5644: 5640: 5635: 5630: 5626: 5622: 5618: 5614: 5610: 5603: 5595: 5591: 5587: 5583: 5579: 5575: 5571: 5564: 5549: 5545: 5541: 5537: 5530: 5522: 5516: 5512: 5511: 5503: 5495: 5493:9781890883539 5489: 5485: 5484: 5476: 5468: 5461: 5453: 5447: 5443: 5437: 5429: 5425: 5421: 5417: 5412: 5407: 5403: 5399: 5395: 5388: 5380: 5376: 5372: 5368: 5364: 5360: 5356: 5352: 5345: 5329: 5325: 5319: 5303: 5297: 5278: 5271: 5265: 5257: 5253: 5249: 5245: 5241: 5237: 5230: 5214: 5207: 5199: 5195: 5191: 5187: 5183: 5179: 5172: 5164: 5160: 5156: 5150: 5146: 5142: 5138: 5131: 5129: 5127: 5118: 5114: 5110: 5106: 5102: 5098: 5094: 5090: 5083: 5075: 5071: 5067: 5063: 5059: 5055: 5048: 5046: 5044: 5035: 5031: 5027: 5023: 5019: 5015: 5011: 5007: 5000: 4992: 4988: 4984: 4980: 4976: 4972: 4968: 4964: 4957: 4949: 4945: 4941: 4937: 4933: 4929: 4922: 4915: 4914:public domain 4896: 4894: 4888: 4882: 4874: 4870: 4866: 4862: 4858: 4854: 4850: 4846: 4839: 4831: 4827: 4823: 4819: 4815: 4811: 4807: 4803: 4796: 4788: 4784: 4780: 4776: 4771: 4766: 4762: 4758: 4754: 4747: 4739: 4735: 4731: 4727: 4723: 4719: 4715: 4711: 4704: 4696: 4692: 4688: 4684: 4680: 4676: 4672: 4668: 4664: 4660: 4653: 4645: 4641: 4637: 4634:(in French). 4633: 4626: 4618: 4614: 4610: 4606: 4602: 4598: 4594: 4590: 4583: 4575: 4571: 4567: 4563: 4559: 4555: 4551: 4547: 4540: 4532: 4528: 4524: 4520: 4516: 4512: 4508: 4504: 4497: 4489: 4485: 4481: 4477: 4470: 4454: 4450: 4444: 4436: 4432: 4428: 4424: 4419: 4414: 4411:(2): 93–107. 4410: 4406: 4402: 4395: 4387: 4383: 4379: 4375: 4371: 4367: 4363: 4359: 4352: 4344: 4340: 4336: 4332: 4328: 4324: 4320: 4316: 4309: 4301: 4297: 4292: 4287: 4283: 4279: 4275: 4268: 4260: 4256: 4252: 4248: 4241: 4233: 4229: 4225: 4221: 4217: 4213: 4206: 4198: 4194: 4190: 4186: 4182: 4178: 4174: 4170: 4163: 4161: 4152: 4148: 4143: 4138: 4133: 4128: 4124: 4120: 4113: 4111: 4102: 4098: 4093: 4088: 4084: 4080: 4076: 4072: 4068: 4061: 4053: 4049: 4045: 4042:(in French). 4041: 4034: 4026: 4022: 4018: 4014: 4010: 4006: 4002: 3998: 3991: 3989: 3980: 3976: 3972: 3968: 3964: 3960: 3953: 3951: 3949: 3940: 3936: 3932: 3928: 3921: 3913: 3909: 3905: 3901: 3897: 3893: 3889: 3885: 3878: 3870: 3866: 3861: 3856: 3852: 3848: 3844: 3837: 3826: 3822: 3818: 3814: 3810: 3806: 3802: 3795: 3788: 3772: 3765: 3763: 3761: 3759: 3757: 3748: 3744: 3739: 3734: 3730: 3726: 3722: 3718: 3714: 3707: 3699: 3695: 3691: 3690: 3686:"Lorazepam". 3682: 3674: 3670: 3666: 3662: 3657: 3652: 3648: 3644: 3640: 3633: 3625: 3621: 3617: 3613: 3609: 3605: 3601: 3597: 3593: 3586: 3584: 3575: 3569: 3561: 3557: 3552: 3547: 3543: 3539: 3535: 3531: 3527: 3520: 3512: 3508: 3504: 3500: 3493: 3485: 3481: 3477: 3473: 3469: 3463: 3459: 3455: 3451: 3447: 3443: 3436: 3428: 3424: 3420: 3416: 3412: 3408: 3404: 3400: 3393: 3385: 3381: 3376: 3371: 3367: 3363: 3359: 3355: 3351: 3344: 3336: 3332: 3327: 3322: 3318: 3314: 3310: 3306: 3302: 3295: 3293: 3284: 3280: 3276: 3272: 3268: 3264: 3260: 3256: 3249: 3241: 3237: 3233: 3229: 3223: 3219: 3215: 3214: 3206: 3198: 3194: 3190: 3186: 3182: 3178: 3171: 3163: 3159: 3158: 3153: 3146: 3131: 3127: 3121: 3105: 3101: 3097: 3091: 3082: 3077: 3073: 3069: 3063: 3050: 3044: 3036: 3032: 3026: 3022: 3018: 3011: 3004: 2996: 2992: 2985: 2979: 2977: 2968: 2964: 2960: 2956: 2952: 2948: 2941: 2939: 2930: 2926: 2922: 2918: 2914: 2910: 2906: 2902: 2895: 2893: 2891: 2889: 2887: 2885: 2883: 2881: 2879: 2877: 2868: 2864: 2859: 2854: 2850: 2846: 2842: 2835: 2833: 2816: 2812: 2808: 2802: 2794: 2790: 2786: 2782: 2778: 2774: 2766: 2758: 2754: 2750: 2746: 2742: 2738: 2734: 2730: 2723: 2715: 2711: 2707: 2703: 2699: 2695: 2688: 2672: 2668: 2664: 2658: 2656: 2654: 2652: 2650: 2648: 2646: 2644: 2642: 2640: 2638: 2636: 2634: 2632: 2630: 2613: 2609: 2603: 2587: 2583: 2577: 2561: 2557: 2551: 2535: 2531: 2525: 2509: 2505: 2499: 2483: 2479: 2473: 2457: 2453: 2449: 2445: 2439: 2433: 2428: 2413: 2409: 2405: 2399: 2391: 2387: 2381: 2377: 2376: 2368: 2360: 2356: 2350: 2346: 2345: 2338: 2322: 2318: 2312: 2308: 2307: 2299: 2283: 2279: 2275: 2269: 2265: 2257: 2255: 2251: 2243: 2233: 2231: 2227: 2223: 2213: 2211: 2206: 2202: 2197: 2195: 2189: 2174: 2172: 2168: 2164: 2160: 2156: 2152: 2148: 2144: 2140: 2136: 2127: 2118: 2116: 2112: 2108: 2104: 2100: 2098: 2094: 2090: 2086: 2082: 2078: 2073: 2071: 2067: 2063: 2059: 2055: 2051: 2047: 2043: 2039: 2034: 2032: 2022: 2013: 2011: 2007: 2003: 1998: 1994: 1992: 1972: 1968: 1958: 1954: 1952: 1948: 1944: 1941: 1937: 1933: 1922: 1920: 1916: 1907: 1903: 1899: 1895: 1891: 1887: 1877: 1875: 1872: 1868: 1857: 1855: 1849: 1847: 1844: 1840: 1836: 1832: 1827: 1825: 1821: 1817: 1813: 1809: 1805: 1801: 1797: 1793: 1789: 1785: 1781: 1776: 1771: 1761: 1758: 1754: 1750: 1749:phenobarbital 1746: 1742: 1741:carbamazepine 1738: 1734: 1730: 1726: 1721: 1718: 1714: 1713:disinhibitory 1704: 1702: 1701: 1696: 1692: 1688: 1687:derealization 1685:, dizziness, 1684: 1678: 1676: 1672: 1667: 1663: 1659: 1655: 1651: 1640: 1637: 1632: 1628: 1626: 1618: 1614: 1606: 1599:and involves 1597: 1593: 1588: 1586: 1582: 1578: 1564: 1561: 1558: 1555: 1552: 1549: 1545: 1541: 1537: 1533: 1530: 1527: 1522: 1521: 1511: 1507: 1503: 1499: 1495: 1491: 1487: 1483: 1479: 1478:breastfeeding 1475: 1472: 1469: 1466: 1463: 1460: 1457: 1453: 1452:aqueous humor 1449: 1445: 1442: 1439: 1436: 1432: 1429: 1426: 1422: 1418: 1415: 1412: 1408: 1405: 1404: 1403: 1394: 1391: 1383: 1372: 1369: 1365: 1362: 1358: 1355: 1351: 1348: 1344: 1341: – 1340: 1336: 1335:Find sources: 1329: 1325: 1319: 1318: 1313:This section 1311: 1307: 1302: 1301: 1293: 1291: 1290:boxed warning 1287: 1279: 1275: 1271: 1267: 1264: 1263:disinhibition 1260: 1256: 1251: 1250: 1249: 1247: 1241: 1238: 1234: 1230: 1226: 1221: 1217: 1213: 1209: 1199: 1197: 1193: 1188: 1186: 1182: 1177: 1168: 1166: 1162: 1157: 1153: 1143: 1141: 1137: 1133: 1129: 1125: 1121: 1117: 1113: 1112:premedication 1108: 1106: 1102: 1092: 1090: 1085: 1082: 1078: 1074: 1070: 1066: 1062: 1057: 1055: 1054:phenobarbital 1051: 1047: 1043: 1034: 1025: 1023: 1018: 1016: 1011: 997: 991: 987: 982: 980: 979:hip fractures 976: 972: 968: 964: 960: 956: 952: 948: 944: 940: 936: 932: 928: 923: 921: 917: 916:intravenously 913: 912:transdermally 909: 905: 901: 897: 893: 889: 885: 881: 877: 873: 869: 865: 861: 857: 853: 849: 845: 837: 827: 820: 814: 805: 800: 799: 796: 789: 780: 779: 776: 769: 762: 758: 757: 755: 752: 747: 740: 738: 734: 701: 699: 695: 690: 686: 682: 679: 677: 675:ECHA InfoCard 671: 663: 659: 658:DTXSID7023225 655: 654: 652: 643: 639: 632: 628: 627: 625: 623: 619: 612: 608: 607: 605: 603: 599: 592: 588: 587: 585: 583: 579: 572: 568: 567: 565: 563: 559: 552: 548: 547: 545: 543: 539: 532: 528: 527: 525: 523: 519: 512: 508: 507: 505: 498: 494: 487: 483: 482: 480: 478: 474: 466: 461: 460: 457: 450: 445: 442: 439: 437: 433: 429: 427: 423: 419: 417: 410: 406: 404: 400: 397: 394: 391: 389: 385: 381: 379: 375: 371: 367: 360: 357: 345: 342: 332: 329: 320: 318: 309: 306: 296: 293: 283: 282: 280: 278: 274: 269: 261: 256: 253: 252: 250: 248: 244: 241: 238: 236: 232: 229: 225: 221: 220:intramuscular 217: 214: 212: 206: 202: 200: 194: 190: 188: 182: 176: 167: 166: 164: 162: 156: 149: 144: 135: 134: 132: 130: 126: 122: 118: 116: 112: 108: 104: 102: 98: 94: 90: 86: 82: 80: 76: 73:Clinical data 71: 67: 62: 58: 53: 45: 41: 37: 33: 19: 17486:Chloroarenes 17406: 17405: 17316:Talniflumate 16854: 16843:Tetrodotoxin 16833:Neosaxitoxin 16824: 16769: 16743:Propoxycaine 16678:Dimethocaine 16611: 16607: 16576:Valnoctamide 16506:Fosphenytoin 16467: 16441:Procainamide 16431:Pilsicainide 16386:Disopyramide 16372: 16362: 16210: 16178: 16128: 16042: 16010:Ethosuximide 15995:Cloperastine 15973: 15942:Metahexamide 15937:Glycyclamide 15897:Glibornuride 15862: 15811: 15773: 15752:Thioridazine 15707:Promethazine 15692:Orphenadrine 15682:Ketoconazole 15667:Erythromycin 15556: 15319: 15247:Phensuximide 15227:Ochratoxin A 15167:Ethosuximide 15093: 15015:-selective ( 15007: 14917: 14874: 14861: 14843: 14792:ω-Conotoxins 14785: 14735: 14717:Norverapamil 14682:Dexverapamil 14660: 14634:derivatives: 14630: 14627:Vatanidipine 14622:Trombodipine 14587:Palonidipine 14572:Nitrendipine 14527:Mepirodipine 14432:Azelnidipine 14415: 14409: 14318: 14317: 14288: 14145:Lavender oil 13887:Nitric oxide 13807:Cryofluorane 13752:Acetophenone 13710:Methaqualone 13705:Mecloqualone 13700:Mebroqualone 13690:Diproqualone 13685:Cloroqualone 13614:Glutethimide 13418: 13370: 13337: 13299: 13272:Testosterone 13237:Progesterone 13202:Hydroxydione 13151:Androsterone 13078:Acecarbromal 12983:constituents 12770:Cyclarbamate 12760:Carisoprodol 12532:Metaclazepam 12527:Menitrazepam 12517:Meclonazepam 12512:Lormetazepam 12506: 12442:Flutemazepam 12267:Ciclotizolam 12257:Carburazepam 12149:Thiobarbital 12109:Secobarbital 12074:Phetharbital 12054:Nealbarbital 12039:Methohexital 12024:Hexobarbital 11959:Butallylonal 11954:Butobarbital 11909:Barbexaclone 11904:Aprobarbital 11889:Allobarbital 11876:Barbiturates 11843: 11835: 11825:Petrichloral 11685: 11565:Promethazine 11497:Metopimazine 11427:cannabinoids 11331:Palonosetron 11135:Hydroxydione 11068:Remifentanil 11009: 10962:Methohexital 10957:Hexobarbital 10944:Barbiturates 10827:Cyclopropane 10814:Inhalational 10759:Valnoctamide 10661:Metaglycodol 10656:Fenpentadiol 10566:Daridorexant 10469:Thioridazine 10420:Trimipramine 10355:Medetomidine 10283:Thioridazine 10234:Trimipramine 10179:Propiomazine 10174:Promethazine 9980:Petrichloral 9965:Kavalactones 9897:Acetophenone 9866:Methaqualone 9861:Mecloqualone 9856:Mebroqualone 9846:Diproqualone 9841:Cloroqualone 9803:Glutethimide 9699:Progesterone 9689:Hydroxydione 9621:Acecarbromal 9535:Carisoprodol 9477:Lormetazepam 9462:Flutemazepam 9364:Secobarbital 9324:Methohexital 9314:Hexobarbital 9294:Butobarbital 9289:Butabarbital 9279:Aprobarbital 9269:Allobarbital 9261:Barbiturates 9045:Lorpiprazole 9035:Fabomotizole 9025:Benzoctamine 8927:Vortioxetine 8903: 8870:clomipramine 8825:escitalopram 8712:Carisoprodol 8692:Barbiturates 8683: 8654: 8568: 8534:Tandospirone 8393:Fenfluramine 8373:Brivaracetam 8322:Sulfonamides 8320: 8255: 8240: 8237:Phensuximide 8227:Ethosuximide 8222:Succinimides 8220: 8200: 8159: 8139:Carboxamides 8137: 8117: 8092: 8079:Fosphenytoin 8067: 8028: 8018: 7981: 7936: 7912: 7886: 7871: 7843:Barbexaclone 7838:Barbiturates 7836: 7518:Ciclotizolam 6971: 6961:Metaclazepam 6956:Menitrazepam 6946:Meclonazepam 6935:Lormetazepam 6929: 6884:Flutemazepam 6758:Carburazepam 6660:. 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Retrieved 5206: 5185: 5181: 5171: 5136: 5092: 5088: 5082: 5057: 5053: 5009: 5005: 4999: 4966: 4962: 4956: 4931: 4927: 4921: 4901:23 September 4899:. Retrieved 4890: 4881: 4848: 4844: 4838: 4805: 4801: 4795: 4760: 4756: 4746: 4713: 4709: 4703: 4666: 4662: 4652: 4635: 4631: 4625: 4592: 4588: 4582: 4549: 4545: 4539: 4506: 4502: 4496: 4479: 4475: 4469: 4457:. Retrieved 4453:the original 4443: 4408: 4404: 4394: 4361: 4357: 4351: 4318: 4314: 4308: 4281: 4277: 4267: 4250: 4249:(in Dutch). 4246: 4240: 4215: 4211: 4205: 4175:(1): 57–62. 4172: 4168: 4122: 4074: 4070: 4060: 4043: 4039: 4033: 4000: 3996: 3962: 3958: 3930: 3929:(in Dutch). 3926: 3920: 3887: 3883: 3877: 3853:(1): 79–81. 3850: 3846: 3836: 3825:the original 3804: 3800: 3787: 3775:. Retrieved 3720: 3716: 3706: 3688: 3681: 3646: 3642: 3632: 3602:(1): 49–57. 3599: 3595: 3568:cite journal 3533: 3529: 3519: 3505:(1): 80–92. 3502: 3498: 3492: 3445: 3435: 3402: 3398: 3392: 3357: 3353: 3343: 3308: 3304: 3258: 3254: 3248: 3212: 3205: 3180: 3176: 3170: 3155: 3145: 3133:. Retrieved 3129: 3120: 3108:. Retrieved 3099: 3090: 3081:10665/325771 3071: 3062: 3043: 3020: 3010: 3003:recommended. 3001: 2950: 2946: 2907:(2): 69–86. 2904: 2900: 2848: 2844: 2819:. Retrieved 2810: 2801: 2776: 2772: 2765: 2732: 2728: 2722: 2700:(1): 57–63. 2697: 2693: 2687: 2675:. Retrieved 2666: 2616:. Retrieved 2611: 2602: 2590:. Retrieved 2585: 2576: 2564:. Retrieved 2559: 2550: 2538:. Retrieved 2533: 2524: 2512:. Retrieved 2507: 2498: 2486:. Retrieved 2481: 2472: 2460:. Retrieved 2438: 2427: 2415:. Retrieved 2407: 2398: 2374: 2367: 2343: 2337: 2325:. Retrieved 2305: 2298: 2286:. Retrieved 2277: 2268: 2239: 2219: 2216:Legal status 2198: 2191: 2169:'s original 2132: 2105: 2101: 2074: 2035: 2027: 1999: 1995: 1964: 1955: 1946: 1945: 1928: 1883: 1880:Pharmacology 1876:metabolism. 1863: 1850: 1828: 1820:barbiturates 1777: 1773: 1722: 1710: 1707:Interactions 1700:That's Life! 1698: 1679: 1646: 1633: 1629: 1589: 1573: 1401: 1386: 1377: 1367: 1360: 1353: 1346: 1334: 1322:Please help 1317:verification 1314: 1283: 1242: 1205: 1192:chemotherapy 1189: 1174: 1149: 1109: 1098: 1086: 1073:prophylactic 1059:Lorazepam's 1058: 1040:Intravenous 1039: 1019: 1012: 1008: 1000:Medical uses 983: 924: 910:(by mouth), 847: 843: 842: 823: 817: 464: 413:Elimination 277:Legal status 271:Legal status 129:License data 44: 36:Lormetazepam 17461:Anxiolytics 17456:Antiemetics 16982:Triamterene 16936:Poneratoxin 16926:Ciguatoxins 16813:Raxatrigine 16808:Ralfinamide 16803:PF-05089771 16798:PF-04531083 16770:Analgesics: 16728:Piperocaine 16713:Meprylcaine 16708:Mepivacaine 16663:Cinchocaine 16642:Ropivacaine 16634:Bupivacaine 16561:Sipatrigine 16546:Pheneturide 16541:Phenacemide 16526:Mephenytoin 16511:Lamotrigine 16491:Elpetrigine 16446:Propafenone 16391:Dronedarone 15967:Tolbutamide 15957:Repaglinide 15952:Nateglinide 15947:Mitiglinide 15927:Glisoxepide 15912:Glimepiride 15902:Glicaramide 15882:Carbutamide 15784:Linopirdine 15767:Vernakalant 15757:Tolterodine 15747:Terfenadine 15737:Tamulotoxin 15732:Solifenacin 15702:PNU-282,987 15677:Haloperidol 15672:Gigactonine 15652:Domperidone 15637:Darifenacin 15602:Bedaquiline 15587:Azaspiracid 15550:Vernakalant 15485:Linopirdine 15445:Dronedarone 15435:Dendrotoxin 15420:Clamikalant 15292:Tolperisone 15287:Tetrandrine 15277:Sipatrigine 15272:Silperisone 15257:Prenylamine 15197:Lidoflazine 15152:Elpetrigine 15062:Mirogabalin 14966:Lamotrigine 14961:Flunarizine 14956:Efonidipine 14946:Cinnarizine 14941:Cilnidipine 14896:NNC 55-0396 14822:Ralfinamide 14769:Fantofarone 14764:Dronedarone 14749:Budiodarone 14744:Brinazarone 14707:Levemopamil 14607:Sornidipine 14602:Sagandipine 14592:Pranidipine 14567:Nisoldipine 14557:Nilvadipine 14547:Niguldipine 14537:Nicardipine 14502:Lemildipine 14487:Iganidipine 14482:Furnidipine 14447:Cronidipine 14442:Clevidipine 14437:Barnidipine 14427:Aranidipine 14227:Stiripentol 14222:Seproxetine 14192:Niacinamide 14172:Loreclezole 13993:Avermectins 13957:Vinyl ether 13927:Sevoflurane 13907:Paraldehyde 13857:Halopropane 13680:Afloqualone 13662:Tracazolate 13657:ICI-190,622 13647:Cartazolate 13624:Piperidione 13619:Methyprylon 13586:Fospropofol 13508:Pipequaline 13316:Pazinaclone 13306:Eszopiclone 13162:Cholesterol 13146:Androstenol 13070:Monoureides 13050:Methysticin 12850:Tetrabamate 12830:Pentabamate 12820:Meprobamate 12790:Febarbamate 12755:Carisbamate 12707:Triflubazam 12697:Tolufazepam 12657:Rilmazafone 12652:Remimazolam 12627:Proflazepam 12612:Pivoxazepam 12572:Nitrazepate 12562:Nimetazepam 12497:Lopirazepam 12467:Haloxazolam 12417:Fludiazepam 12362:Doxefazepam 12337:Delorazepam 12317:Clotiazepam 12312:Clorazepate 12277:Cinolazepam 12174:Vinbarbital 12129:Tetrabamate 12084:Probarbital 12064:Phenallymal 12029:Metharbital 12004:Febarbamate 11899:Amobarbital 11800:Isopropanol 11770:Chloralodol 11671:Amisulpride 11627:antagonists 11613:Scopolamine 11608:Hyoscyamine 11604:(very mild) 11602:Hydroxyzine 11578:antagonists 11555:Hydroxyzine 11526:antagonists 11487:Hydroxyzine 11482:Haloperidol 11469:antagonists 11406:Ziprasidone 11401:Risperidone 11391:Hydroxyzine 11356:Tropisetron 11335:+netupitant 11326:Ondansetron 11316:Mirtazapine 11301:Granisetron 11281:Cilansetron 11239:Antiemetics 11181:from market 11048:Embutramide 11043:Anileridine 11015:Remimazolam 10952:Amobarbital 10929:Fospropofol 10892:Vinyl ether 10882:Sevoflurane 10744:Scopolamine 10688:Guaifenesin 10683:Fenadiazole 10639:Cannabidiol 10613:Mirogabalin 10571:Lemborexant 10548:Tasimelteon 10533:Agomelatine 10492:Risperidone 10438:Mirtazapine 10327:-Adrenergic 10306:Risperidone 10252:Mirtazapine 10202:Etoperidone 10169:Pheniramine 10154:Hydroxyzine 9975:Paraldehyde 9970:Loreclezole 9836:Afloqualone 9818:Piperidione 9808:Methyprylon 9737:Pazinaclone 9717:Eszopiclone 9679:Alphaxolone 9674:Alphadolone 9613:Monoureides 9555:Meprobamate 9492:Nitemazepam 9487:Nimetazepam 9432:Doxefazepam 9417:Cinolazepam 9389:Vinbarbital 9354:Proxibarbal 9339:Phenallymal 9274:Amobarbital 9226:Chloralodol 9126:from market 9055:Mepiprazole 9040:Hydroxyzine 9030:Cycloserine 9008:propranolol 8950:Flupentixol 8907:Agomelatine 8885:mirtazapine 8706:meprobamate 8640:Fludiazepam 8615:Clotiazepam 8610:Clorazepate 8491:Anxiolytics 8433:from market 8383:Carisbamate 8378:Cannabidiol 8264:Lamotrigine 8168:Lamotrigine 8119:Fatty acids 8114:Pheneturide 8109:Phenacemide 8084:Mephenytoin 7983:Fatty acids 7964:Stiripentol 7959:Paraldehyde 7923:Nimetazepam 7903:Clorazepate 7848:Metharbital 7743:Rilmazafone 7717:Anthramycin 7610:Lopirazepam 7594:Telenzepine 7553:Fluetizolam 7479:Clotiazepam 7446:Haloxazolam 7390:Remimazolam 7365:I-Iomazenil 7308:Rilmazafone 7179:Triflubazam 7128:Tolufazepam 7039:Proflazepam 7029:Pivoxazepam 6999:Nitrazepate 6989:Nitemazepam 6984:Nimetazepam 6869:Fludiazepam 6834:Doxefazepam 6798:Delorazepam 6788:Clorazepate 6773:Cinolazepam 6683:IPCS INCHEM 6577:21 February 6520:29 December 5324:"Lorazepam" 4632:L'Encéphale 4405:Drug Safety 4142:10454/16512 3884:Drugs Aging 2663:"Lorazepam" 2618:7 September 2592:7 September 2566:7 September 2540:7 September 2514:7 September 2488:7 September 2274:"Lorazepam" 2254:clorazepate 2159:clorazepate 2081:intravenous 1973:at the GABA 1940:glucuronide 1874:glucuronide 1843:intravenous 1800:hypotension 1745:lamotrigine 1695:tachycardia 1611:receptors, 1462:Sleep apnea 1339:"Lorazepam" 1246:hypotension 1185:haloperidol 1152:haloperidol 1116:intravenous 858:(including 744: g·mol 681:100.011.534 447:Identifiers 420:10–20 hours 358:Schedule IV 317:Schedule IV 228:transdermal 224:intravenous 115:MedlinePlus 88:Other names 79:Trade names 17450:Categories 17286:Bumetanide 17224:Activators 17214:Piretanide 17209:Lonidamine 17160:Activators 17145:Mibefradil 17140:Mefloquine 17130:Furosemide 17125:Fluoxetine 17105:Crofelemer 16992:Activators 16915:Versutoxin 16911:Robustoxin 16893:Activators 16878:Safinamide 16828:Conotoxins 16763:Trimecaine 16758:Tetracaine 16733:Prilocaine 16723:Orthocaine 16698:Iontocaine 16693:Hexylcaine 16688:Etidocaine 16629:Benzocaine 16619:Amylocaine 16601:Zonisamide 16596:Valpromide 16566:Topiramate 16556:Rufinamide 16516:Lacosamide 16481:Cenobamate 16436:Prajmaline 16426:Moricizine 16421:Mexiletine 16416:Lorcainide 16401:Flecainide 16366:Ranolazine 16306:Activators 16291:Fluoxetine 16235:Nimesulide 16217:-specific: 16203:Activators 16185:-specific: 16137:-specific: 16117:Rilmakalim 16107:Nicorandil 16067:Cromakalim 16054:-specific: 16035:Activators 16025:Tipepidine 16015:Ifenprodil 15990:Caramiphen 15982:-specific: 15962:Tolazamide 15922:Gliquidone 15907:Gliclazide 15874:-specific: 15827:Retigabine 15822:Flupirtine 15819:-specific: 15804:Activators 15781:-specific: 15762:Vanoxerine 15742:Terodiline 15727:Sertindole 15717:Ranolazine 15582:Astemizole 15572:Amiodarone 15540:Terikalant 15515:Pinokalant 15500:Nifekalant 15495:Maurotoxin 15490:Lolitrem B 15480:Kaliotoxin 15440:Dofetilide 15430:Dalazatide 15425:Conotoxins 15395:Amiodarone 15390:Almokalant 15312:Activators 15302:Valperinol 15282:Terodiline 15222:Naftopidil 15212:Mesuximide 15142:Enpiperate 15122:Cycleanine 15107:Bevantolol 15097:Bencyclane 15087:Pregabalin 15077:PD-299,685 15072:PD-217,014 15067:PD-200,347 15057:Imagabalin 15047:Gabapentin 15037:Atagabalin 15027:Arbaclofen 14986:Mibefradil 14981:Loperamide 14976:Lomerizine 14951:Dotarizine 14931:Benidipine 14911:Zonisamide 14827:Safinamide 14802:Caroverine 14754:Celivarone 14702:Gallopamil 14657:Siratiazem 14647:Iprotiazem 14637:Clentiazem 14617:Tiamdipine 14612:Teludipine 14577:Olradipine 14562:Nimodipine 14552:Niludipine 14542:Nifedipine 14532:Mesudipine 14522:Manidipine 14497:Lacidipine 14492:Isradipine 14477:Flordipine 14472:Felodipine 14467:Elnadipine 14462:Elgodipine 14452:Darodipine 14422:Amlodipine 14260:Topiramate 14250:Terpenoids 14207:Propanidid 14197:Org 25,435 14125:Flupirtine 14120:Fluoxetine 14026:Chloralose 13997:ivermectin 13902:Norflurane 13867:Isoflurane 13812:Desflurane 13802:Chloroform 13762:Aliflurane 13695:Etaqualone 13523:SB-205,384 13453:CP-615,003 13448:CL-218,872 13402:Panadiplon 13392:Lorediplon 13321:Suproclone 13282:Zuranolone 13242:Renanolone 13227:Posovolone 13207:Minaxolone 13197:Ganaxolone 13136:Alfaxalone 13131:Alfadolone 13121:Acebrochol 13088:Bromisoval 12966:Metomidate 12953:Imidazoles 12913:Hispidulin 12865:Flavonoids 12825:Nisobamate 12815:Mebutamate 12785:Ethinamate 12780:Emylcamate 12747:Carbamates 12717:Tuclazepam 12692:Tetrazepam 12647:Reclazepam 12622:Premazepam 12602:Phenazepam 12582:Nordazepam 12577:Nitrazolam 12567:Nitrazepam 12547:Motrazepam 12502:Loprazolam 12492:Lofendazam 12477:Imidazenil 12437:Flutazolam 12432:Flurazepam 12402:Fletazepam 12357:Dimdazenil 12352:Diclazepam 12332:Cyprazepam 12322:Cloxazolam 12302:Clonazolam 12297:Clonazepam 12287:Climazolam 12247:Brotizolam 12242:Bromazolam 12237:Bromazepam 12232:Bretazenil 12227:Bentazepam 12217:Arfendazam 12212:Alprazolam 12207:Adinazolam 12179:Vinylbital 12159:Thiopental 12034:Methitural 11949:Buthalital 11944:Butalbital 11795:Isobutanol 11655:Rolapitant 11650:Netupitant 11645:Maropitant 11635:Aprepitant 11436:Dronabinol 11396:Olanzapine 11361:Zatosetron 11351:Ricasetron 11346:Ramosetron 11341:Quetiapine 11321:Olanzapine 11306:Lerisetron 11296:Dolasetron 11276:Bemesetron 11156:Propanidid 11130:Alfaxalone 11125:Alfadolone 11107:Tiletamine 11092:Esketamine 11074:Sufentanil 11058:Alfentanil 10977:Thiopental 10862:Isoflurane 10832:Desflurane 10822:Chloroform 10712:Metaxalone 10702:Mephenesin 10623:Pregabalin 10603:Gabapentin 10576:Suvorexant 10511:Niaprazine 10487:Quetiapine 10482:Olanzapine 10365:Tizanidine 10360:Romifidine 10350:Lofexidine 10340:Detomidine 10301:Quetiapine 10296:Olanzapine 10207:Nefazodone 10149:Doxylamine 10134:Captodiame 9945:Chloralose 9909:compounds 9851:Etaqualone 9747:Suproclone 9727:Lirequinil 9694:Minaxolone 9684:Eltanolone 9664:Acebrochol 9631:Bromisoval 9598:Metomidate 9585:Imidazoles 9545:Ethinamate 9540:Emylcamate 9527:Carbamates 9502:Nitrazolam 9497:Nitrazepam 9472:Loprazolam 9457:Flurazepam 9427:Clonazolam 9422:Climazolam 9412:Brotizolam 9394:Vinylbital 9379:Thiopental 9070:Oxaflozane 8998:guanfacine 8945:Quetiapine 8922:Vilazodone 8917:Tianeptine 8900:phenelzine 8840:duloxetine 8798:Pregabalin 8783:Gabapentin 8702:Carbamates 8665:Nordazepam 8620:Cloxazolam 8605:Clonazepam 8585:Bromazepam 8580:Alprazolam 8575:Adinazolam 8408:Perampanel 8398:Ganaxolone 8388:Etiracetam 8347:Zonisamide 8342:Topiramate 8292:Retigabine 8274:Zonisamide 8269:Topiramate 8252:Pregabalin 8247:Gabapentin 8232:Mesuximide 8183:Zonisamide 8178:Topiramate 8173:Rufinamide 8163:Lacosamide 8129:Valpromide 8069:Hydantoins 8051:modulators 8003:Vigabatrin 7993:Valpromide 7928:Nitrazepam 7898:Clonazepam 7878:Cenobamate 7873:Carbamates 7813:GABAergics 7682:Premazepam 7665:Zometapine 7589:Olanzapine 7558:Israpafant 7523:Clotizolam 7513:Brotizolam 7474:Bentazepam 7441:Flutazolam 7436:Cloxazolam 7415:Sarmazenil 7375:Loprazolam 7360:Imidazenil 7350:Flumazenil 7335:Climazolam 7330:Bretazenil 7304:Rilmazolam 7294:Phenazolam 7289:Nitrazolam 7259:Clonazolam 7254:Bromazolam 7248:Balovaptan 7243:Alprazolam 7238:Adinazolam 7215:Talampanel 7205:GYKI-52895 7200:GYKI-52466 7174:Lofendazam 7159:Arfendazam 7138:Tuclazepam 7111:Tetrazepam 7054:Reclazepam 7019:Phenazepam 7004:Nordazepam 6994:Nitrazepam 6966:Motrazepam 6920:Kenazepine 6879:Flurazepam 6864:Fletazepam 6824:Diclazepam 6813:Devazepide 6793:Cyprazepam 6778:Clonazepam 6747:BMS-906024 6742:Bromazepam 6598:. Vienna: 5540:StatPearls 2417:22 October 2260:References 2203:visits by 2186:See also: 2155:bromazepam 2151:flurazepam 2147:nitrazepam 2139:clonazepam 2068:with 2.0% 2058:tartrazine 2046:polacrilin 2031:sublingual 1886:anxiolytic 1854:counseling 1846:flumazenil 1788:drowsiness 1780:dysarthria 1768:See also: 1643:Withdrawal 1613:uncoupling 1581:alprazolam 1350:newspapers 1233:depression 1132:anxiolysis 931:sleepiness 874:including 749:3D model ( 737:Molar mass 611:CHEBI:6539 571:O26FZP769L 542:ChemSpider 477:CAS Number 456:IUPAC name 388:Metabolism 328:Anlage III 235:Drug class 185:Dependence 40:Loratadine 32:Loprazolam 17407:See also: 17306:Mepacrine 17252:Ivacaftor 17168:Carbachol 17051:Ibuprofen 17041:Amiloride 17000:Solnatide 16972:Amiloride 16901:Aconitine 16863:Evenamide 16838:Saxitoxin 16753:Risocaine 16703:Lidocaine 16648:Butacaine 16624:Articaine 16551:Phenytoin 16461:Tocainide 16456:Sparteine 16451:Quinidine 16411:Lorajmine 16406:Lidocaine 16396:Encainide 16381:Aprindine 16122:Sarakalim 16112:Pinacidil 16102:Naminidil 16092:Minoxidil 16087:Mazokalim 16072:Diazoxide 16062:Bimakalim 16057:Aprikalim 16020:Tertiapin 16000:Clozapine 15917:Glipizide 15712:Quinidine 15662:Ergtoxins 15627:Cisapride 15617:BRL-32872 15597:Azimilide 15560:(KCNH2, K 15535:Tedisamil 15520:Quinidine 15510:Paxilline 15475:Inakalant 15470:Ibutilide 15455:Hanatoxin 15410:Bunaftine 15405:Bretylium 15400:Azimilide 15385:Adekalant 15344:Potassium 15326:Bay K8644 15267:Sesamodil 15217:Monatepil 15207:Manoalide 15202:Magnesium 15187:Imepitoin 15177:Fendiline 15157:Ethadione 15147:Eperisone 15127:Dauricine 15102:Berbamine 15013:δ subunit 14817:PD-173212 14732:Verapamil 14722:Ronipamil 14712:Nexopamil 14697:Falipamil 14692:Etripamil 14677:Devapamil 14672:Dagapamil 14652:Nictiazem 14642:Diltiazem 14632:Diltiazem 14582:Oxodipine 14319:See also: 14281:valerenol 14202:Phenytoin 14182:Monastrol 14140:Lanthanum 14135:KRM-II-81 14098:Fenamates 14093:Etifoxine 14088:Etazepine 14083:Efavirenz 14041:Darigabat 13937:Teflurane 13922:Roflurane 13917:Propylene 13862:Halothane 13847:Fluroxene 13832:Enflurane 13735:Volatiles 13652:Etazolate 13563:Viqualine 13518:RWJ-51204 13483:L-838,417 13473:Imepitoin 13443:CGS-20625 13438:CGS-13767 13423:Adipiplon 13397:Ocinaplon 13359:Saripidem 13354:Necopidem 13331:Zopiclone 13326:Suriclone 13311:Pagoclone 13217:ORG-21465 13212:ORG-20599 13103:Ectylurea 13093:Carbromal 12971:Propoxate 12961:Etomidate 12888:Baicalein 12845:Styramate 12840:Procymate 12810:Lorbamate 12795:Felbamate 12765:Clocental 12737:Zomebazam 12732:Zolazepam 12727:Zapizolam 12722:Uldazepam 12702:Triazolam 12687:Temazepam 12682:Sulazepam 12672:Ro48-8684 12667:Ro48-6791 12662:Ripazepam 12632:Pyrazolam 12607:Pinazepam 12557:Nifoxipam 12542:Midazolam 12537:Mexazolam 12522:Medazepam 12507:Lorazepam 12487:Ketazolam 12482:Irazepine 12472:Iclazepam 12462:Halazepam 12457:Gidazepam 12452:Fosazepam 12372:Estazolam 12367:Elfazepam 12342:Demoxepam 12272:Cinazepam 12252:Camazepam 12222:Avizafone 12144:Thiamylal 12079:Primidone 12009:Heptabarb 11999:Eterobarb 11964:Carbubarb 11861:Triclofos 11760:Brometone 11691:Midazolam 11686:Lorazepam 11560:Meclizine 11540:Cyclizine 11381:Clozapine 11311:Mianserin 11291:Dazopride 11286:Clozapine 11271:Azasetron 11266:Alosetron 11191:Phase III 11179:Withdrawn 11151:Etomidate 11038:Oxycodone 11010:Lorazepam 11000:Midazolam 10972:Thiamylal 10907:Injection 10857:Halothane 10852:Fluroxene 10842:Enflurane 10749:Trazodone 10690:-related 10543:Ramelteon 10538:Melatonin 10525:Melatonin 10433:Mianserin 10400:Trazodone 10335:Clonidine 10247:Mianserin 10212:Trazodone 10164:Perlapine 10007:Triclofos 9960:Gaboxadol 9767:Zopiclone 9752:Suriclone 9742:Saripidem 9732:Necopidem 9646:Ectylurea 9641:Carbromal 9603:Propoxate 9593:Etomidate 9570:Procymate 9517:Triazolam 9512:Temazepam 9482:Midazolam 9437:Estazolam 9374:Thiamylal 9309:Heptabarb 9188:sedatives 9184:Hypnotics 9136:Phase III 9124:Withdrawn 9105:Validolum 9100:Tofisopam 9095:Tiagabine 9085:Picamilon 9065:Opipramol 8990:clonidine 8912:Bupropion 8855:trazodone 8745:Zopiclone 8737:Hypnotics 8727:Etifoxine 8675:Pinazepam 8660:Medazepam 8655:Lorazepam 8650:Ketazolam 8645:Halazepam 8590:Camazepam 8524:Buspirone 8443:Phase III 8431:Withdrawn 8368:Beclamide 8259:Imepitoin 8207:Ethadione 8124:Valproate 8089:Phenytoin 8035:Tiagabine 8025:Progabide 7988:Valproate 7954:Imepitoin 7933:Temazepam 7918:Midazolam 7913:Lorazepam 7883:Felbamate 7868:Primidone 7738:Avizafone 7660:Zomebazam 7655:Zolazepam 7650:Ripazepam 7644:Razobazam 7628:Zapizolam 7570:Metizolam 7484:Ro09-9212 7451:Mexazolam 7410:Ro4938581 7405:Ro48-8684 7400:Ro48-6791 7395:Ro15-4513 7380:Midazolam 7370:L-655,708 7314:Triazolam 7299:Pyrazolam 7264:Estazolam 7220:Tofisopam 7210:Nerisopam 7195:Girisopam 7143:Uldazepam 7122:Timelotem 7116:Tifluadom 7106:Temazepam 7101:Sulazepam 7096:SH-I-048A 7091:Ro20-8552 7086:Ro20-8065 7081:Ro07-9749 7076:Ro07-5220 7065:Ro05-4082 7059:RO4491533 7024:Pinazepam 6979:Nifoxipam 6951:Medazepam 6940:Lufuradom 6930:Lorazepam 6925:Ketazolam 6914:Irazepine 6909:Iclazepam 6904:Halazepam 6899:Gidazepam 6894:Fosazepam 6839:Elfazepam 6803:Demoxepam 6768:Cinazepam 6753:Camazepam 5962:(2): 54. 5398:Epilepsia 5286:3 October 4609:0895-8017 4459:10 August 3530:CNS Drugs 3236:173659630 3135:30 August 3110:30 August 2667:drugs.com 2462:16 August 1824:modulator 1792:hypotonia 1753:phenytoin 1737:Valproate 1733:rifabutin 1729:hypnotics 1727:or other 1683:dysphoria 1675:psychosis 1658:addiction 1585:triazolam 1510:metabolic 1498:hypotonia 1474:Pregnancy 1380:June 2017 1176:Catatonia 1146:Agitation 1120:midazolam 1081:tolerance 1050:phenytoin 955:depressed 870:, active 844:Lorazepam 631:ChEMBL580 436:Excretion 415:half-life 209:Routes of 199:liability 197:Addiction 187:liability 159:Pregnancy 148:Lorazepam 107:Monograph 101:Drugs.com 49:Lorazepam 17440:Medicine 17392:instead. 17367:instead. 17278:Blockers 17270:Unsorted 17196:Blockers 17097:Blockers 17074:Chloride 17036:A-317567 17028:Blockers 16977:Benzamil 16964:Blockers 16793:NKTR-171 16788:GDC-0276 16783:Funapide 16778:DSP-2230 16773:AZD-3161 16738:Procaine 16653:Butamben 16501:Ethotoin 16376:Ajmaline 16355:Blockers 16314:Riluzole 16273:Blockers 16171:Blockers 16077:Emakalim 15855:Blockers 15697:Pimozide 15567:Ajmaline 15367:Blockers 15182:Fostedil 15112:Canadine 15082:Phenibut 15042:Baclofen 14991:NP078585 14936:Bepridil 14774:SR-33805 14727:Tiapamil 14687:Emopamil 14667:Anipamil 14402:Blockers 14307:TCS-1205 14302:TCS-1105 14292:α-Pinene 14265:Valerian 14240:tetronal 14217:Safranal 14166:obovatol 14162:magnolol 14158:honokiol 13988:Alogabat 13983:AA-29504 13932:Synthane 13892:Nitrogen 13872:Kerosine 13852:Gasoline 13842:Ethylene 13782:Centalun 13777:Butylene 13591:Propofol 13553:U-89843A 13533:TGSC01AA 13503:NS-11394 13468:GBLD-345 13433:CGS-9896 13428:CGS-8216 13412:Zaleplon 13407:Taniplon 13387:Indiplon 13382:Fasiplon 13377:Divaplon 13364:Zolpidem 13267:SAGE-872 13262:SAGE-689 13257:SAGE-516 13252:SAGE-324 13247:SAGE-105 13155:Certain 13098:Capuride 13060:Yangonin 12937:baicalin 12933:Skullcap 12923:Luteolin 12898:Catechin 12893:Baicalin 12883:Apigenin 12855:Tybamate 12642:Quazepam 12637:QH-II-66 12617:Prazepam 12597:Oxazolam 12592:Oxazepam 12392:Etizolam 12347:Diazepam 12327:CP-1414S 12292:Clobazam 12282:Clazolam 12169:Valofane 12124:Talbutal 12114:Sigmodal 12019:Hexethal 11914:Barbital 11894:Alphenal 11884:(-)-DMBB 11830:Propanol 11820:Pentanol 11810:Methanol 11752:Alcohols 11696:Propofol 11592:Atropine 11450:cannabis 11441:Nabilone 11422:agonists 11097:Ketamine 11053:Fentanyl 11033:Morphine 11005:Diazepam 10934:Propofol 10924:Ciprofol 10847:Ethylene 10733:morphine 10724:Midaflur 10644:Cannabis 10618:Phenibut 10370:Xylazine 10099:Phenibut 10069:Baclofen 9995:Tetronal 9930:Centalun 9785:Propofol 9762:Zolpidem 9757:Zaleplon 9722:Indiplon 9636:Capuride 9575:Tybamate 9507:Quazepam 9369:Talbutal 9284:Barbital 9213:Alcohols 9080:Phenibut 9060:Nicotine 8980:prazosin 8793:Phenibut 8773:blockers 8680:Prazepam 8670:Oxazepam 8635:Etizolam 8625:Diazepam 8600:Clobazam 8529:Gepirone 8516:agonists 8363:Albutoin 8337:Sultiame 8074:Ethotoin 7908:Diazepam 7893:Clobazam 7761:ligands) 7759:receptor 7698:Clazolam 7538:Etizolam 7456:Oxazolam 7355:GL-II-73 7169:CP-1414S 7164:Clobazam 7070:Ro5-4864 7049:QH-II-66 7044:Quazepam 7034:Prazepam 7014:Oxazepam 6819:Diazepam 6656:Archived 6549:16336040 6459:16351526 6430:22560361 6393:1 August 6351:20496680 6343:14524641 6306:Archived 6263:43017514 6112:16243469 6076:76854489 6028:11937649 5990:Archived 5986:30618719 5978:17213084 5934:16714516 5885:Archived 5881:45073171 5873:11898891 5750:Archived 5674:15078112 5643:16322061 5594:18855614 5548:29489152 5420:23205959 5379:42918932 5371:18277121 5328:Archived 5277:Archived 5198:Archived 5194:10779253 5163:18175099 5109:18399712 5074:19900604 4991:27014006 4873:24789150 4865:15899744 4787:18103662 4779:15483562 4738:78865613 4695:Archived 4691:38614605 4683:15460178 4644:15029082 4617:12186578 4574:44387644 4566:15961964 4531:35313827 4427:26563222 4386:24371644 4343:21940883 4300:15888767 4259:16956088 4197:24505811 4151:23633309 4101:27885664 4052:16119296 4017:15916448 3979:16305452 3939:15771339 3912:68771929 3904:15554749 3747:18176312 3698:31643878 3673:25904252 3665:16053464 3560:35971024 3511:10030438 3484:24523838 3476:17433931 3427:22205104 3419:16384688 3384:25207925 3335:16179702 3240:Archived 3162:Archived 3130:ClinCalc 3104:Archived 3100:ClinCalc 3070:(2019). 3035:Archived 2995:Archived 2967:20171127 2929:24453988 2921:18384456 2867:28257172 2815:Archived 2793:16143486 2757:42138460 2749:10966246 2671:Archived 2586:DailyMed 2560:DailyMed 2534:DailyMed 2456:Archived 2390:Archived 2359:Archived 2321:Archived 2282:Archived 2143:oxazepam 2135:diazepam 2091:400 and 2085:ampoules 2033:tablet. 1936:diazepam 1932:vascular 1915:diazepam 1894:hypnotic 1890:sedative 1871:oxazepam 1764:Overdose 1757:rifampin 1671:seizures 1636:diazepam 1605:receptor 1560:Comorbid 1544:oxazepam 1506:cyanosis 1504:spells, 1456:glaucoma 1448:glaucoma 1225:explicit 1161:delirium 1156:sedation 1136:hypnosis 1105:propofol 1095:Sedation 1042:diazepam 1028:Seizures 1015:insomnia 949:, and a 927:weakness 872:seizures 826:(verify) 522:DrugBank 486:846-49-1 305:Class B1 247:ATC code 216:By mouth 203:Moderate 161:category 143:DailyMed 17506:Lactims 17491:Lactams 17046:Aspirin 16868:Menthol 16855:Others: 16825:Toxins: 16668:Cocaine 16193:GAL-021 15813:KCNQ (K 15775:KCNQ (K 15592:AZD1305 15530:Sotalol 15525:ShK-186 15505:Notoxin 15192:JTV-519 15172:Fasudil 14901:ProTx I 14881:ABT-639 14868:SNX-482 14739:AH-1058 14736:Others: 14379:Calcium 14254:borneol 14252:(e.g., 14244:trional 14234:(e.g., 14152:(e.g., 14150:Lignans 14100:(e.g., 14058:(e.g., 14003:Bromide 13995:(e.g., 13978:α-EMTBL 13942:Toluene 13912:Propane 13787:Chloral 13767:Benzene 13747:Acetone 13578:Phenols 13568:Y-23684 13558:U-90042 13543:TPA-023 13528:SX-3228 13513:ROD-188 13498:NS-2710 13493:NS-2664 13478:JM-1232 13463:ELB-139 13458:CTP-354 13344:Alpidem 12943:Wogonin 12918:Linarin 12397:FG-8205 12104:Reposal 11805:Menthol 11765:Butanol 11025:Opioids 10916:Phenols 10731:(e.g., 10729:Opioids 10678:Evoxine 10415:Doxepin 10229:Doxepin 10104:Tolibut 10000:Trional 9907:Bromide 9777:Phenols 9359:Reposal 9050:Mebicar 9006:(e.g., 8988:(e.g., 8978:(e.g., 8904:Others: 8898:(e.g., 8883:(e.g., 8868:(e.g., 8853:(e.g., 8838:(e.g., 8823:(e.g., 8704:(e.g., 8694:(e.g., 8687:Alpidem 8684:Others: 8256:Others: 8160:Others: 8094:Ureides 8049:Channel 7940:Bromide 7937:Others: 7507:Apafant 7385:PWZ-029 7345:FG-8205 7340:EVT-201 6290:2450203 6255:8395663 6214:7708722 6182:Bibcode 6155:2092144 6147:2743706 5925:2564351 5834:3234245 5634:1464231 5553:13 June 5428:4675696 5256:6133446 5117:8473906 5034:7881198 5014:Bibcode 4983:6124415 4948:1968716 4822:6120058 4523:3137624 4488:6120763 4435:7946506 4378:8545533 4335:9877014 4232:8835707 4189:9469682 4092:6464403 3821:8625666 3738:2763279 3624:1389910 3616:8700792 3551:9477921 3450:273–285 3375:7154380 3326:1226249 3275:6120058 3197:6144459 2821:16 July 2677:15 July 2327:13 July 2236:Pricing 2210:suicide 2121:History 2111:hospice 2064:400 in 2038:lactose 1898:amnesic 1831:emetics 1725:opioids 1717:amnesic 1691:myalgia 1542:. Like 1435:alcohol 1407:Allergy 1364:scholar 1278:solvent 1270:amnesic 1140:amnesia 1005:Anxiety 959:suicide 904:cocaine 902:due to 890:and to 856:anxiety 698:Formula 531:DB00186 497:PubChem 361:Rx-only 355:WARNING 315:: 263:) 257: ( 255:N05BA06 174: C 145:: 121:a682053 18:Temesta 17426:Portal 17343:Others 16332:Sodium 15985:Barium 15789:XE-991 15657:E-4031 15607:BeKm-1 15577:AmmTX3 15460:HgeTx1 15450:E-4031 15232:Osthol 15001:TROX-1 14886:ML-218 14187:Niacin 13772:Butane 13725:SL-164 13596:Thymol 13538:TP-003 13419:Others 13222:P1-185 13182:5β-DHP 13177:5α-DHP 13172:3α-DHP 13020:Kavain 12928:Rc-OMe 11664:Others 11174:WHO-EM 11144:Others 10632:Others 10558:Orexin 10504:Others 10494:, etc. 10471:, etc. 10440:, etc. 10422:, etc. 10308:, etc. 10285:, etc. 10254:, etc. 10236:, etc. 9890:Others 9881:SL-164 9119:WHO-EM 9090:Selank 9018:Others 8426:WHO-EM 8356:Others 8305:Others 8012:Others 6662:14 May 6547: 6496:639854 6494: 6457: 6428: 6349: 6341: 6288: 6261: 6253: 6212: 6202: 6153: 6145: 6110: 6074: 6066: 6026: 5984: 5976: 5932: 5922: 5879: 5871: 5832: 5791:13 May 5729:13 May 5704: 5672: 5641: 5631: 5592: 5546: 5517: 5490: 5448: 5426: 5418: 5377: 5369: 5334:14 May 5308:14 May 5254: 5219:1 June 5192: 5161: 5151: 5115: 5107: 5072: 5032: 4989: 4981: 4946: 4871: 4863: 4830:464310 4828: 4820: 4785: 4777: 4736: 4728: 4689: 4681: 4642: 4615: 4607: 4572: 4564: 4529: 4521: 4486: 4433: 4425: 4384: 4376: 4341: 4333: 4298: 4257: 4230: 4195: 4187: 4149: 4099: 4089: 4050: 4025:692414 4023: 4015: 3977: 3937: 3910: 3902: 3869:238548 3867: 3819: 3777:13 May 3745: 3735: 3696: 3671: 3663: 3622: 3614: 3558: 3548: 3509: 3482: 3474: 3464: 3425: 3417: 3382: 3372: 3333: 3323: 3283:464310 3281: 3273: 3234: 3224: 3195: 3055: 3027: 2965: 2927: 2919: 2865: 2791: 2755: 2747: 2712: 2444:Anvisa 2382: 2351: 2313: 2288:18 May 2205:SAMHSA 2171:patent 2157:, and 2079:or by 1904:, and 1837:, and 1814:, and 1796:ataxia 1755:, and 1660:, and 1583:, and 1548:kidney 1502:apneic 1441:Ataxia 1366: 1359: 1352: 1345: 1337: 1216:ataxia 1138:, and 994: 935:ataxia 908:orally 892:sedate 882:, and 848:Ativan 775:SMILES 742:321.16 622:ChEMBL 591:D00365 441:Kidney 352: 339: 303: 290: 141: 17377:LGICs 17084:CaCCs 17056:PcTX1 17015:ASICs 16342:VGSCs 15612:BmTx3 15465:HsTx1 15354:VGKCs 14389:VDCCs 14046:DEABL 13739:gases 13548:TP-13 13277:THDOC 13167:DHDOC 10897:Xenon 10754:UMB68 10074:GABOB 8892:MAOIs 8877:TeCAs 8847:SARIs 8832:SNRIs 8817:SSRIs 6631:(PDF) 6624:(PDF) 6607:(PDF) 6596:(PDF) 6347:S2CID 6259:S2CID 6205:42301 6151:S2CID 6072:S2CID 5993:(PDF) 5982:S2CID 5952:(PDF) 5877:S2CID 5424:S2CID 5375:S2CID 5280:(PDF) 5273:(PDF) 5113:S2CID 4987:S2CID 4963:Drugs 4895:(FDA) 4891:U.S. 4869:S2CID 4826:S2CID 4783:S2CID 4734:S2CID 4730:15198 4687:S2CID 4570:S2CID 4527:S2CID 4431:S2CID 4382:S2CID 4339:S2CID 4193:S2CID 4021:S2CID 3997:Drugs 3908:S2CID 3828:(PDF) 3801:Chest 3797:(PDF) 3669:S2CID 3620:S2CID 3480:S2CID 3423:S2CID 3279:S2CID 2998:(PDF) 2987:(PDF) 2925:S2CID 2851:(2). 2753:S2CID 2714:31453 2508:(emc) 2482:(emc) 2242:Mylan 2167:Wyeth 1816:death 1532:Liver 1371:JSTOR 1357:books 1171:Other 1126:. 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