273:. He was a featured scientist on the PBS NOVA television program on epigenetics in 2007 entitled Ghost in Your Genes. He was the inaugural recipient of the Epigenetic Medicine Award. In 2009, Jirtle received the STARS Lecture Award in Nutrition and Cancer from the National Cancer Institute. Dr. Jirtle was invited in 2012 to present the NIH Director’s WALS lecture. He received the Linus Pauling Award from the Institute of Functional Medicine in 2014. ShortCutsTV produced a documentary in 2017 based upon Jirtle’s epigenetic research entitled, Are You What Your Mother Ate? The Agouti Mouse Study He received in 2018 the Northern Communities Health Foundation Visiting Professorship Award at University of Adelaide in Australia. Personalized Lifestyle Medicine Institute presented Jirtle with the Research and Innovation Leadership Award in 2019. In 2019, he also received the Alexander Hollaender Award from the Environmental Mutagenesis and Genomics Society stating, “The award recognizes Dr. Jirtle’s discovery that the environment can influence inheritance of phenotypic traits through epigenetic reprogramming representing one of the most important scientific advances of the 21st century.”
31:
220:) altered the coat color distribution and disease susceptibility in genetically identical offspring by increasing DNA methylation at the A locus. A subsequent study showed that the phyto-estrogen, genistein, modifies the fetal epigenome, alters coat color, and protects Agouti offspring from obesity even though it is not capable of donating a methyl group. This article was selected as the ‘Classic Paper of the Year’ in 2011 by
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173:). Following post-doctoral studies, Jirtle was appointed assistant professor of radiology at Duke University in 1980, and became Professor of Radiation Oncology in 1990 and Associate Professor of Pathology in 1998. He remained at Duke until 2012, and is currently Professor of Epigenetics in the Department of Biological Sciences at North Carolina State University, Raleigh, NC.
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genome - the human imprintome. The group has now developed a custom methylation array to allow targeted investigation of the ICRs of the human imprintome ]. The availability of this research tool will be useful in determining the contribution of imprinted genes to human health, and to diseases and disorders such as
Alzheimer’s disease.
246:
These mice are genetically identical despite looking phenotypically different. The mouse on the left's mother was fed
Bisphenol A (BPA) with a normal mouse diet and the mouse on the right's mother was fed BPA with a methyl-rich diet. The left mouse is yellow and obese, while the right mouse is brown
197:
Parent-of-origin-dependent monoallelic expression of imprinted genes is regulated by imprinted control regions (ICRs) which are differentially methylated during gametogenesis, and the Jirtle laboratory recently identified 1,488 hemi-methylated candidate imprint control regions (ICRs) in the human
193:
Jirtle initially took a phylogenetic approach to the study of genomic imprinting, examining allelic expression, in a range of mammalian orders (and in non-mammalian vertebrates), of the genes encoding the IGF2R (also known as the cation-independent mannose 6-phosphate receptor, CI-MPR) and its
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Jirtle's early research examined the influence of radiation on biological systems. He developed the first in vivo clonogenic assay for hepatocytes, and used it to quantify their survival when exposed to X-rays and neutrons. Jirtle also used this clonal assay to study the phenomenon of liver
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He has edited a book on Liver
Regeneration and Carcinogenesis, and two books on Environmental Epigenomics in Health and Disease. Jirtle is on the editorial board of the journals Epigenomics published by Taylor & Francis, Epigenetics published by Taylor & Francis, and Environmental
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Jirtle has received a number of awards in recognition of his achievements. He was honored in 2006 with the
Distinguished Achievement Award from the College of Engineering at the University of Wisconsin-Madison. In 2007 Jirtle was nominated to be
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ligand, IGF2. He was the first to show that imprinting arose in an ancestor of metatherian and therian mammals, which feature placentation and live birth, but is not a feature of prototherian (egg-laying) mammals.
224:. It was followed by a study that showed that genistein and methyl donor supplementation can counteract detrimental epigenetic effects induced by a controversial xenobiotic chemical, bisphenol A (
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Evolution of genomic imprinting and identifying imprinted genes. Showing that environmental agents alter the epigenome, thereby affecting health and disease susceptibility in adulthood.
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Jirtle RL, Michalopoulos G, McLain JR, Crowley J (1981), "Transplantation system for determining the clonogenic survival of parenchymal hepatocytes exposed to ionizing radiation",
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Dolinoy DC, Weidman JR, Waterland RA, Jirtle RL (2006), "Maternal genistein alters coat color and protects Avy mouse offspring from obesity by modifying the fetal epigenome",
485:
Barlow DP, Stoger R, Herrmann BG, Saito K, Schweifer N (1991), "The mouse insulin-like growth factor type-2 receptor is imprinted and closely linked to the Tme [
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De Souza AT, Hankins GR, Washington MK, Orton TC, Jirtle RL (1995), "M6P/IGF2R gene is mutated in human hepatocellular carcinomas with loss of heterozygosity",
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Bernal AJ, Dolinoy DC, Huang D, Skaar DA, Weinhouse C, Jirtle RL (2013), "Adaptive radiation-induced epigenetic alterations mitigated by antioxidants",
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Jirtle RL, Michalopoulos G, Strom SC, DeLuca PM, Gould MN (1984), "The survival of parenchymal hepatocytes irradiated with low and high LET radiation",
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Hankins GR, De Souza AT, Bentley RC, Patel MR, Marks JR, Iglehart JD, Jirtle RL (1996), "M6P/IGF2 receptor: a candidate breast tumor suppressor gene",
161:, graduating with a B.S. degree in nuclear engineering. For graduate school, he remained at the University of Wisconsin-Madison, obtaining an M.S. in
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Dolinoy DC, Huang D, Jirtle RL (2007), "Maternal nutrient supplementation counteracts bisphenol A-induced DNA hypomethylation in early development",
145:, and for his use of the Agouti mouse model to investigate the effect of environmental agents on the mammalian epigenome and disease susceptibility.
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In 2003, Jirtle provided molecular evidence that maternal dietary supplementation of Agouti viable yellow (A) mice with methyl donors (i.e.
133:, the branch of biology that deals with inherited information that does not reside in the nucleotide sequence of DNA. Jirtle retired from
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Jirtle RL, Biles C, Michalopoulos G (1980), "Morphologic and histochemical analysis of hepatocytes transplanted into syngeneic hosts",
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Duke
University, University of Wisconsin-Madison, University of Bedfordshire, North Carolina State University, University of Adelaide
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Waterland RA, Jirtle RL (2003), "Transposable elements: targets for early nutritional effects on epigenetic gene regulation",
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Jirtle RL, McLain JR, Strom SC, Michalopoulos G (1982), "Repair of radiation damage in noncycling parenchymal hepatocytes",
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232:, induce positive adaptive responses in the offspring by altering the epigenome, and that these changes are mitigated by
190:, and to studies in the emerging field of genomic imprinting, since murine IGF2R was shown at that time to be imprinted.
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228:). Jirtle used the A mouse system to show that embryonic stem cells exposed in vivo to low doses of a physical agent,
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regeneration. These early studies ultimately led to the identification of the insulin-like growth factor receptor (
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138:
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137:, Durham, NC in 2012. He is presently Professor of Epigenetics in the Department of Biological Sciences at
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922:"2006 Distinguished career award: Randy Jirtle - College of Engineering - University of Wisconsin-Madison"
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Jirtle RL, Michalopoulos G (1982), "Effects of partial hepatectomy on transplanted hepatocytes",
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Environmental
Epigenomics in Health and Disease: Epigenetics and Complex Diseases Origins
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https://clinicalepigeneticsjournal.biomedcentral.com/articles/10.1186/s13148-024-01672-4
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https://www.engr.wisc.edu/alumnus-randy-jirtle-receives-2019-alexander-hollaender-award/
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1121:"EMGS is Proud to Announce the 2019 Alexander Hollaender and EMGS Award Recipients"
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Environmental
Epigenomics in Health and Disease: Epigenetics and Disease Origins
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770:"Low Dose Radiation-Induced Epigenetic Alterations Found in Agouti Mouse Model"
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986:"Article: New Epigenetic Science Award Presented in Groundbreaking Ceremony"
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129:(born November 9, 1947) is an American biologist noted for his research in
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Liver
Regeneration and Carcinogenesis: Cellular and Molecular Mechanisms
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College of
Engineering - University of Wisconsin-Madison 1 March 2019
292:, Cold Spring Harbor, New York: Cold Spring Harbor Laboratory Press,
1008:"NIH VideoCast - Epigenetics, Nutrition and Disease Susceptibility"
555:
https://www.tandfonline.com/doi/full/10.1080/15592294.2022.2091815
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1022:"NIH VideoCast - Epigenetics: How Genes and Environment Interact"
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311:"Alumnus Randy Jirtle receives 2019 Alexander Hollaender Award"
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Allis, CD, Jenuwein T, Reinberg D, Caparros, M-L (eds.) (2007),
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https://link.springer.com/article/10.1186/s43682-024-00028-6
1099:"2019 Thought Leaders Consortium Schedule | PLM Institute"
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Epigenetic
Origins of Human Health, Professor Randy Jirtle
970:
884:
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Tilson HA (2011), "EHP Classic Paper of the Year, 2011",
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659:"Prenatal Genistein in Soy Reduces Obesity in Offspring"
618:"A Pregnant Mother's Diet May Turn the Genes Around"
141:, Raleigh, NC. Jirtle is noted for his research on
673:"Folate Shields Fetus Against Chemical in Plastics"
252:Epigenetics published by Oxford University Press.
92:Epigenetics, Genomic imprinting, Radiation biology
1036:"Randy Jirtle, PHD, Receives Linus Pauling Award"
1155:
157:. He attended Algoma Public High School and the
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814:
772:. US Department of Energy. November 8, 2007
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896:Environmental Epigenetics Editorial Board
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542:https://pubmed.ncbi.nlm.nih.gov/11455432/
529:https://pubmed.ncbi.nlm.nih.gov/11479919/
516:https://pubmed.ncbi.nlm.nih.gov/10882106/
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1156:
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616:Blakeslee, Sandra (October 7, 2003).
839:Jirtle, RL; Tyson, FL, eds. (2013),
815:Jirtle, RL; Tyson, FL, eds. (2013),
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165:in 1973 and a PhD in 1976 (Major:
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946:. Time Magazine. November 8, 2007
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222:Environmental Health Perspectives
271:National Institute on Drug Abuse
1142:Ghost in your genes (Nova, PBS)
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1050:"Are You What Your Mother Ate?"
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681:. HealthDay News. July 31, 2007
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139:North Carolina State University
69:University of Wisconsin-Madison
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795:, San Diego: Academic Press,
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566:Carreras-Gallo et al. 2024 (
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892:"Environmental Epigenetics"
176:
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1137:Genomic Imprinting Website
988:. OpEd News. May 30, 2008
944:"Person of the Year 2007"
265:’s Person of the Year by
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88:
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843:, Heidelberg: Springer,
819:, Heidelberg: Springer,
791:Jirtle, RL, ed. (1995),
701:Environ Health Perspect
636:Environ Health Perspect
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1010:. September 29, 2009.
966:"Ghost in Your Genes"
932:on September 9, 2016.
527:Killian et al. 2001 (
514:Killian et al. 2000 (
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188:tumor suppressor gene
149:Early life and career
1174:American geneticists
579:Cevik et al. 2024 (
35:Randy Jirtle in 2020
678:The Washington Post
540:Nolan et al. 2001 (
155:Kewaunee, Wisconsin
153:Jirtle was born in
58:Kewaunee, Wisconsin
16:American geneticist
1147:Nova (Epigenetics)
622:The New York Times
553:Jima et al. 2022 (
269:, Director of the
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143:genomic imprinting
1109:on March 2, 2019.
1024:. April 18, 2012.
926:www.engr.wisc.edu
395:Br J Cancer Suppl
167:Radiation Biology
163:Radiation Biology
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83:Scientific career
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66:Alma mater
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1066:Archived at
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127:Randy Jirtle
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116:.geneimprint
97:Institutions
82:
1164:1947 births
752:: 665–671.
641:: 567–572.
446:: 447–449.
418:Cancer Res.
400:: 197–201.
377:: 847–851.
372:Br J Radiol
331:: 115–126.
326:Am J Pathol
290:Epigenetics
244:Agouti Mice
131:epigenetics
1158:Categories
802:012388649X
349:Cancer Res
298:0879698756
277:References
203:folic acid
171:Statistics
47:1947-11-09
906:April 17,
498:: 84–87.
441:Nat Genet
211:vitamin B
169:; Minor:
1070:and the
758:23118028
735:17670942
712:21628120
706:: A238.
647:16581547
605:12861015
464:Oncogene
177:Research
1084:YouTube
992:July 3,
950:May 23,
776:May 23,
747:FASEB J
685:July 3,
504:1845916
475:8649861
452:7493029
429:7046913
406:6692410
383:6753999
360:7020930
337:6108719
218:betaine
207:choline
109:Website
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493:Nature
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256:Awards
230:X-rays
216:, and
89:Fields
60:, U.S.
184:IGF2R
994:2022
952:2013
908:2015
845:ISBN
821:ISBN
797:ISBN
778:2013
754:PMID
731:PMID
724:PNAS
708:PMID
687:2022
643:PMID
601:PMID
500:PMID
471:PMID
448:PMID
425:PMID
402:PMID
379:PMID
356:PMID
333:PMID
294:ISBN
118:.com
41:Born
971:PBS
727:104
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639:114
496:349
488:sic
329:101
226:BPA
114:www
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Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
