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A small vial of the Gosio/Biginelli mercurichloride is to this day preserved at The Museum of the
History of Medicine (Museo di Storia della Medicina) in Rome, Italy. Under the printed name "Laboratorio Batteriologico della SanitĂ Pubblica" is handwritten, "arsina penicillare comp. mercurico". From
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and Zimmer in 1898 were not the salts of carbonic acid, that true quinine carbonate is very bitter, that their action on the organism is slight and slow compared with that of quinine, and that euquinine is ethyl quinine carboxylate,
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After leaving his post as a director of the
Chemical Laboratory of State Medicine, Biginelli, as he himself stated, focused mainly on the problems of chemical commodity research, e.g. distinguishing between true and false
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Istituto
Superiore di Sanitа. Microanalisi elementare organica. Collezione di strumenti a cura di Anna Farina e Cecilia Bedetti. 2007, I beni storico-scientifi ci dell’Istituto Superiore di Sanitа, p 26
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Istituto
Superiore di Sanitа. Microanalisi elementare organica. Collezione di strumenti a cura di Anna Farina e Cecilia Bedetti. 2007, I beni storico-scientifi ci dell’Istituto Superiore di Sanitа, p 25
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Istituto
Superiore di Sanitа. Microanalisi elementare organica. Collezione di strumenti a cura di Anna Farina e Cecilia Bedetti. 2007, I beni storico-scientifi ci dell’Istituto Superiore di Sanitа, p 24
307:, a chemist known for his discovery of arsenic-containing volatile gas known as "Gosio gas". From 1925 to 1928, Biginelli worked as a director of the above-mentioned chemical laboratory.
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growing on wallpapers painted by arsenic-containing paints. Finally, Gosio and
Biginelli succeeded in isolating and analyzing the species: when Gosio gas was passed into a solution of
388:. These conclusions were based on the property shown by tannin of forming additive products with water, alcohol, and ether, (which are stable even in vacuum) and also on the loss of
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Another scope of his research interests emerged when he was assistant of
Bartolomeo Gosio. At that time, it was known that certain poisonous volatile arsenic species tend to form at
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with open-chain acyclic structures. However, later he corrected himself this interpretation and expanded his initial studies, showing that the end products actually were
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322:, was focused on synthesis and reactivity of chlorobromonaphthalene. Already in the University of Florence, Biginelli described a three-component reaction between
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Challenger, F., C. Higginbottom, L. Ellis. The formation of organo-metalloid compounds by microorganisms. Part I. Trimethylarsine and dimethylethylarsine.
334:, which was at first incorrectly interpreted as one leading to the formation of alpha-benzuramido-crotonacetic ester, or ethyl-alpha-salicyluramido-
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Annuario della r. Universita degli studi di Torino per l'anno accademico. By
UniversitĂ di Torino, UniversitĂ di Torino, 1885, p. 310
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In 1901, Biginelli, as coadjutor, moved to the
Chemical Laboratory of State Medicine in Rome, where he was working as an assistant of
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245:(25 July 1860 – 15 January 1937) was an Italian chemist, who discovered a three-component reaction between
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285:, a well-known Italian chemist and chemistry historian. In 1885, he was already a 4th-year student.
261:). He also studied various aspects of sanitation chemistry and chemical products' quality control.
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Biginelli, P. Composizione e costituzione chimica del gas arsenicale delle tappezzerie. Nota II.
35:
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Biginelli, P. Composizione e costituzione chimica del gas arsenicale delle tappezzerie. Nota I.
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Bentley R., Chasteen T.G. Microbial
Methylation of Metalloids: Arsenic, Antimony, and Bismuth.
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Molinari E. Treatise on General and Industrial Organic Chemistry, pt. II, London, 1923, p. 689
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Molinari E. Treatise on General and Industrial Organic Chemistry, pt. II, London, 1923, p.723
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analysis of this material and of the gas itself it appeared that the gas was diethyl
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Biginelli's first known scientific work, in which he was a co-author of his mentor
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Gosio, B., Action de quelques moisissures sure les composés fixes d’ársenic.
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in dilute HCl (Biginelli's solution) a crystalline precipitate was formed.
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342:. However, Biginelli did not change the chemical names presented earlier.
292:, where 2 years later he developed a method which later would be known as
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Bigineli P. Derivati aldeiduredici degli eteri acetil- e dossal-acetico.
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By 1891, Biginelli worked at the chemical laboratory at the
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Biginelli P. Ueber Aldehyduramide des Acetessigaethers II.
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Biginelli P. Ueber Aldehyduramide des Acetessigaethers.
400:(the amount of carbon dioxide liberated was estimated).
679:Fleck, H.Z., Ueber den Arsengehalt der Zimmerluft.
49:. Unsourced material may be challenged and removed.
403:In 1914, Biginelli showed that aristoquinine and
396:, when tannin is heated in aqueous solution with
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787:Marotta D. Camillo Manuelli e Pietro Biginelli.
464:of commercial quinine, artificial tannins, etc.
667:Berichte der Deutschen Chemischen Gesellschaft
639:Berichte der Deutschen Chemischen Gesellschaft
511:Berichte der Deutschen Chemischen Gesellschaft
697:Microbiology and Molecular Biology Reviews
392:and water with formation of hexa-hydroxy-
109:Learn how and when to remove this message
296:. In 1897, he was already in Rome, as a
739:Challenger, F. Biological methylation.
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310:He died in Rome on 15 January 1937.
47:adding citations to reliable sources
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34:needs additional citations for
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407:carbonate placed in market by
368:Biginelli stated in 1911 that
294:Biginelli Pyrimidine synthesis
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833:20th-century Italian chemists
818:19th-century Italian chemists
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745:, 1945, vol. 36, pp. 315–361.
586:, 1893, vol. 18, pp. 253–265.
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546:, Abstr., 1893, p. 645
290:University of Florence
219:University of Florence
700:, 2002, p. 250 – 251.
627:., 1887, pp. 518--519
314:Scientific interests
271:Palazzolo Vercellese
145:Palazzolo Vercellese
43:improve this article
279:University of Turin
182:University of Turin
760:. 1933, pp. 95–101
332:ethyl acetoacetate
277:. He attended the
259:Biginelli reaction
192:Biginelli reaction
58:"Pietro Biginelli"
583:Arch. Ital. Biol.
559:, 1897, p. ?
372:has the formula C
351:mercuric chloride
281:, studying under
275:Piedmont-Sardinia
251:acetoacetic ester
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231:Icilio Guareschi
226:Doctoral advisor
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394:benzophenone
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298:privatdozent
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215:Institutions
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161:(1937-01-15)
141:25 July 1860
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41:Please help
36:verification
33:
813:1937 deaths
808:1860 births
624:Chem. Zentr
340:pyrimidines
802:Categories
742:Chem. Rev.
555:Ludtke G.
468:References
137:1860-07-25
99:April 2008
69:newspapers
386:glucoside
336:crotonate
265:Biography
255:aldehydes
462:tannates
328:aldehyde
611:, Abstr
557:Minerva
405:quinine
83:scholar
370:tannin
359:arsine
330:, and
205:Fields
85:
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56:
428:·COOC
409:Bayer
347:molds
171:Italy
90:JSTOR
76:books
456:CO.
324:urea
253:and
247:urea
167:Rome
156:Died
131:Born
62:news
45:by
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365:.
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249:,
169:,
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454:2
450:2
448:N
446:2
444:O
440:H
434:5
432:H
430:2
426:2
424:N
422:2
420:O
416:H
412:C
380:O
376:H
257:(
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