Antipsychotic - Knowledge

644:. Antipsychotics in old age dementia showed a modest benefit compared to placebo in managing aggression or psychosis, but this is combined with a fairly large increase in serious adverse events. Thus, antipsychotics should not be used routinely to treat dementia with aggression or psychosis, but may be an option in a few cases where there is severe distress or risk of physical harm to others. Psychosocial interventions may reduce the need for antipsychotics. In 2005, the FDA issued an advisory warning of an increased risk of death when atypical antipsychotics are used in dementia. In the subsequent 5 years, the use of atypical antipsychotics to treat dementia decreased by nearly 50%. 10766: 456:(memory impairments, reduced ability to plan and execute tasks). In general, the efficacy of antipsychotic treatment in reducing positive symptoms appears to increase with the severity of baseline symptoms. All antipsychotic medications work relatively the same way: by antagonizing D2 dopamine receptors. However, there are some differences when it comes to typical and atypical antipsychotics. For example, atypical antipsychotic medications have been seen to lower the neurocognitive impairment associated with schizophrenia more than conventional antipsychotics, although the reasoning and mechanics of this are still unclear to researchers. 469:

family history information to identify patients in the "high-risk" group; they are considered to have a 20–40% risk of progression to frank psychosis within two years. These patients are often treated with low doses of antipsychotic drugs with the goal of reducing their symptoms and preventing progression to frank psychosis. While generally useful for reducing symptoms, clinical trials to date show little evidence that early use of antipsychotics improves long-term outcomes in those with prodromal symptoms, either alone or in combination with cognitive-behavioral therapy.

10889:. It was often taken to refer also to common side effects such as reduced activity in general, as well as lethargy and impaired motor control. Although these effects are unpleasant and in some cases harmful, they were at one time, along with akathisia, considered a reliable sign that the drug was working. The term "ataraxy" was coined by the neurologist Howard Fabing and the classicist Alister Cameron to describe the observed effect of psychic indifference and detachment in patients treated with chlorpromazine. This term derived from the Greek adjective " 573:, as a first-line treatment for manic and mixed episodes associated with bipolar disorder. The reason for this combination is the therapeutic delay of the aforementioned mood stabilizers (for valproate therapeutic effects are usually seen around five days after treatment is commenced whereas lithium usually takes at least a week before the full therapeutic effects are seen) and the comparatively rapid antimanic effects of antipsychotic drugs. The antipsychotics have a documented efficacy when used alone in acute mania/mixed episodes. 1264:(prescribing two or more antipsychotics at the same time for an individual) is a common practice but not evidence-based or recommended, and there are initiatives to curtail it. Similarly, the use of excessively high doses (often the result of polypharmacy) continues despite clinical guidelines and evidence indicating that it is usually no more effective but is usually more harmful. A meta-analysis of observational studies with over two million individuals has suggested a moderate association of antipsychotic use with breast cancer. 1272:

greater in patients treated with first generation antipsychotics relative to those treated with atypicals, and hypothesized a protective effect of atypicals as one possible explanation. A second meta-analysis suggested that treatment with antipsychotics was associated with increased grey matter loss. Animal studies found that monkeys exposed to both first- and second-generation antipsychotics experience significant reduction in brain volume, resulting in an 8-11% reduction in brain volume over a 17–27 month period.

547:(LAI), or "depot", form have been suggested as a method of decreasing medication nonadherence (sometimes also called non-compliance). NICE advises LAIs be offered to patients when preventing covert, intentional nonadherence is a clinical priority. LAIs are used to ensure adherence in outpatient commitment. A meta-analysis found that LAIs resulted in lower rates of rehospitalization with a hazard ratio of 0.83; however, these results were not statistically significant (the 95% confidence interval was 0.62 to 1.11). 768:. Much of the evidence for the off-label use of antipsychotics (for example, for dementia, OCD, PTSD, personality disorders, Tourette's) was of insufficient scientific quality to support such use, especially as there was strong evidence of increased risks of stroke, tremors, significant weight gain, sedation, and gastrointestinal problems. A UK review of unlicensed usage in children and adolescents reported a similar mixture of findings and concerns. A survey of children with 11197:, sedation, confusion and other cognitive adverse effects, weight gain, and increased mortality. Physicians and caretakers of persons with dementia should try to address symptoms including agitation, aggression, apathy, anxiety, depression, irritability, and psychosis with alternative treatments whenever antipsychotic use can be replaced or reduced. Elderly persons often have their dementia treated first with antipsychotics and this is not the best management strategy. 511:

an effect size of about 0.5. There is little or no difference in efficacy among approved antipsychotic drugs, including both first- and second-generation agents. The efficacy of such drugs is suboptimal. Few patients achieve complete resolution of symptoms. Response rates, calculated using various cutoff values for symptom reduction, are low, and their interpretation is complicated by high placebo response rates and selective publication of clinical trial results.

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combination of antipsychotic and sedative effects provides both emotional and physical calming. Assaultive or destructive behavior is rapidly controlled. As therapy continues, the initial sedative effect gradually disappears. But the antipsychotic effect continues, helping to dispel or modify delusions, hallucinations and confusion, while keeping the patient calm and approachable. SMITH KLINE AND FRENCH LABORATORIES leaders in psychopharmaceutical research."

24807: 664:(FDA) labelling for this indication. There is, however, a greater risk of side effects with their use compared to using traditional antidepressants. The greater risk of serious side effects with antipsychotics is why, e.g., quetiapine was denied approval as monotherapy for major depressive disorder or generalized anxiety disorder, and instead was only approved as an adjunctive treatment in combination with traditional antidepressants. 10774: 1366: 1775:(Socian) – Selective dopamine antagonist. Higher doses (greater than 400 mg) act upon post-synaptic dopamine receptors resulting in a reduction in the positive symptoms of schizophrenia, such as psychosis. Lower doses, however, act upon dopamine autoreceptors, resulting in increased dopamine transmission, improving the negative symptoms of schizophrenia. Lower doses of amisulpride have also been shown to have 1374: 528:

dispensed (and presumably took) antipsychotics prior to stopping therapy. If people did not stop taking antipsychotics, they remained at low risk for relapse and hospitalization compared to those that did. The authors speculated that the difference may be because the people that discontinued treatment after a longer time had more severe mental illness than those that discontinued antipsychotic therapy sooner.

1382: 387:, other pharmacological and non-pharmacological interventions are usually attempted before using antipsychotics. A risk-to-benefit analysis is performed to weigh the risk of the adverse effects of antipsychotics versus: the potential benefit, the adverse effects of alternative interventions, and the risk of failing to intervene when a patient's behavior becomes unsafe. The same can be said for 10797:". Lobotomy at the time was used to treat many behavioral disorders, including psychosis, although its effect was to markedly reduce behavior and mental functioning of all types. However, chlorpromazine proved to reduce the effects of psychosis in a more effective and specific manner than lobotomy, even though it was known to be capable of causing severe sedation. The underlying 11044:. Short-acting parenteral formulations also exist, which are generally reserved for emergencies or when oral administration is otherwise impossible. The oral formulations include immediate release, extended release, and orally disintegrating products (which are not sublingual, and can help ensure that medications are swallowed instead of "cheeked"). Sublingual products (e.g., 51: 10899:), which means "not disturbed, not excited, without confusion, steady, calm". In the use of the terms "tranquilizer" and "ataractic", medical practitioners distinguished between the "major tranquilizers" or "major ataractics", which referred to drugs used to treat psychoses, and the "minor tranquilizers" or "minor ataractics", which referred to drugs used to treat 367:(acute mania and mixed episodes) may be treated with either typical or atypical antipsychotics, although atypical antipsychotics are usually preferred because they tend to have more favourable adverse effect profiles and, according to a recent meta-analysis, they tend to have a lower liability for causing conversion from mania to depression. 729:, and a recent network meta-analysis of 154 double-blind, randomized controlled trials of drug therapies vs. placebo for insomnia in adults found that quetiapine did not demonstrated any short-term benefits in sleep quality. Low dose antipsychotics may also be used in treatment of impulse-behavioural and cognitive-perceptual symptoms of 11157:(quetiapine), amidst federal investigations of its marketing practices. By expanding the conditions for which they were indicated, Astrazeneca's Seroquel and Eli Lilly's Zyprexa had become the biggest selling antipsychotics in 2008 with global sales of $ 5.5 billion and $ 5.4 billion respectively. 391:, in which they are not recommended as first-line therapy. There are evidence-based indications for using antipsychotics in children (e.g., tic disorder, bipolar disorder, psychosis), but the use of antipsychotics outside of those contexts (e.g., to treat behavioral problems) warrants significant caution. 524:

long-lasting symptom reduction, 13% achieved remission, and only 27% experienced satisfactory quality of life. The effect of relapse prevention on long term outcomes is uncertain, as historical studies show little difference in long term outcomes before and after the introduction of antipsychotic drugs.

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Antipsychotics were once among the biggest selling and most profitable of all drugs, generating $ 22 billion in global sales in 2008. By 2003 in the US, an estimated 3.21 million patients received antipsychotics, worth an estimated $ 2.82 billion. Over 2/3 of prescriptions were for the

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Note: "Notable" is to mean side-effects that are particularly unique to the antipsychotic drug in question. For example, clozapine is notorious for its ability to cause agranulocytosis. If data on the propensity of a particular drug to cause a particular AE is unavailable an estimation is substituted

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recommends a gradual withdrawal when discontinuing antipsychotics to avoid acute withdrawal syndrome or rapid relapse. Symptoms of withdrawal commonly include nausea, vomiting, and loss of appetite. Other symptoms may include restlessness, increased sweating, and trouble sleeping. Less commonly there

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Test batteries such as the PACE (Personal Assessment and Crisis Evaluation Clinic) and COPS (Criteria of Prodromal Syndromes), which measure low-level psychotic symptoms and cognitive disturbances, are used to evaluate people with early, low-level symptoms of psychosis. Test results are combined with

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In the five years since July 2017 the number of antipsychotic medicines dispensed in the community in the United Kingdom has increased by 11.2%. There have also been substantial price rises. Risperidone 6 mg tablets, the largest, increased from £3.09 in July 2017 to £41.16 in June 2022. The

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and other brain structural changes over time are observed amongst people diagnosed with schizophrenia. Meta-analyses of the effects of antipsychotic treatment on grey matter volume and the brain's structure have reached conflicting conclusions. A 2012 meta-analysis concluded that grey matter loss is

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While maintenance therapy clearly reduces the rate of relapses requiring hospitalization, a large observational study in Finland found that, in people that eventually discontinued antipsychotics, the risk of being hospitalized again for a mental health problem or dying increased the longer they were

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Placebo-controlled trials of both first- and second-generation antipsychotic drugs consistently demonstrate the superiority of active drugs over placebos in suppressing psychotic symptoms. A large meta-analysis of 38 trials of antipsychotic drugs in schizophrenia with acute psychotic episodes showed

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Applications of antipsychotic drugs in the treatment of schizophrenia include prophylaxis for those showing symptoms that suggest that they are at high risk of developing psychosis; treatment of first-episode psychosis; maintenance therapy (a form of prophylaxis, maintenance therapy aims to maintain

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and promoting antipsychotics, including allegations of downplaying or covering up adverse effects, expanding the number of conditions or illegally promoting off-label usage; influencing drug trials (or their publication) to try to show that the expensive and profitable newer atypicals were superior

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Several smaller low-quality clinical studies have reported its efficacy in the treatment of treatment-resistant schizophrenia. Only approved for use in a few European countries. It is known that off-licence prescribing of melperone is occurring in the United Kingdom. Is a butyrophenone, low-potency

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However, the risk of serious adverse effects from clozapine is low, and there are the beneficial effects to be gained of a reduced risk of suicide, and aggression. Typical antipsychotics and atypical risperidone can have a side effect of sexual dysfunction. Clozapine, olanzapine, and quetiapine are

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resulting in many fatalities. Very rare clozapine adverse effects include periorbital edema due to several possible mechanisms (e.g., inhibition of platelet-derived growth factor receptors leading to increased vascular permeability, antagonism of renal dopamine receptors with electrolyte and fluid

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Pharmacological options for the specific treatment of FEP have been discussed in recent reviews. The goals of treatment for FEP include reducing symptoms and potentially improving long-term treatment outcomes. Randomized clinical trials have provided evidence for the efficacy of antipsychotic drugs

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Bartoli F, Cavaleri D, Callovini T, Riboldi I, Crocamo C, D'Agostino A, Martinotti G, Bertolini F, Ostuzzi G, Barbui C, Carrà G (March 2022). "Comparing 1-year effectiveness and acceptability of once-monthly paliperidone palmitate and aripiprazole monohydrate for schizophrenia spectrum disorders:

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conducted research on bipolar disorder in children that led to an increase in such diagnoses. A 2008 Senate investigation found that Biederman also received $ 1.6 million in speaking and consulting fees between 2000 and 2007, some of them undisclosed to Harvard, from companies including makers of

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Use of this class of drugs has a history of criticism in residential care. As the drugs used can make patients calmer and more compliant, critics claim that the drugs can be overused. Outside doctors can feel under pressure from care home staff. In an official review commissioned by UK government

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compared to the atypical agents (8% vs. 2% to 4%). This is significant because any patient with tardive dyskinesia was specifically excluded from randomization to perphenazine; i.e., in the CATIE study the patient cohort randomized to receive perphenazne was at lower risk of having extrapyramidal

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recommend antipsychotics for managing acute psychotic episodes in schizophrenia or bipolar disorder, and as a longer-term maintenance treatment for reducing the likelihood of further episodes. They state that response to any given antipsychotic can be variable so that trials may be necessary, and

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Maintenance therapy with antipsychotic drugs is clearly superior to placebo in preventing relapse but is associated with weight gain, movement disorders, and high dropout rates. A 3-year trial following persons receiving maintenance therapy after an acute psychotic episode found that 33% obtained

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found more than 1,000 patients in their area in July 2019 who had not had regular medication reviews or health checks because they were not registered as having serious mental illness. On average they had been taking these drugs for six years. If this is typical of practice in England more than

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A significant challenge in the use of antipsychotic drugs for the prevention of relapse is the poor rate of adherence. In spite of the relatively high rates of adverse effects associated with these drugs, some evidence, including higher dropout rates in placebo arms compared to treatment arms in

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Leucht S, Cipriani A, Spineli L, Mavridis D, Orey D, Richter F, Samara M, Barbui C, Engel RR, Geddes JR, Kissling W, Stapf MP, Lässig B, Salanti G, Davis JM (September 2013). "Comparative efficacy and tolerability of 15 antipsychotic drugs in schizophrenia: a multiple-treatments meta-analysis".

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Ishibashi T, Horisawa T, Tokuda K, Ishiyama T, Ogasa M, Tagashira R, Matsumoto K, Nishikawa H, Ueda Y, Toma S, Oki H, Tanno N, Saji I, Ito A, Ohno Y, Nakamura M (July 2010). "Pharmacological profile of lurasidone, a novel antipsychotic agent with potent 5-hydroxytryptamine 7 (5-HT7) and 5-HT1A

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that the typical antipsychotics can produce (see above). They were commonly classified on a spectrum of low potency to high potency, where potency referred to the ability of the drug to bind to dopamine receptors, and not to the effectiveness of the drug. High-potency antipsychotics such as

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The text reads: "When the patient lashes out against 'them' – THORAZINE (brand of chlorpromazine) quickly puts an end to his violent outburst. 'Thorazine' is especially effective when the psychotic episode is triggered by delusions or hallucinations. At the outset of treatment, Thorazine's

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that lower doses are to be preferred where possible. A number of studies have looked at levels of "compliance" or "adherence" with antipsychotic regimes and found that discontinuation (stopping taking them) by patients is associated with higher rates of relapse, including hospitalization.

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to bipolar disorder or schizophrenia is lower, with 30% of people converting to either bipolar disorder or schizophrenia. NICE makes no distinction between substance-induced psychosis and any other form of psychosis. The rate of conversion differs for different classes of drugs.

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recommends a gradual withdrawal when discontinuing antipsychotic treatment to avoid acute withdrawal syndrome or rapid relapse. The process of cross-titration involves gradually increasing the dose of the new medication while gradually decreasing the dose of the old medication.

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appeared to be at a heightened risk for developing type II diabetes mellitus. Evidence suggests that females are more sensitive to the metabolic side effects of first-generation antipsychotic drugs than males. Metabolic adverse effects appear to be mediated by antagonizing the

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alone leads to a worse disease outcome. This effect is especially pronounced in younger patients with psychotic unipolar depression. Considering the wide use of such combination therapies, further studies on the side effects of antipychotics as an add-on therapy are warranted.

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receptor antagonist, received its first global approval in the US for the treatment of schizophrenia in adults. In 2020 and 2021 FDA approved for depressive episodes associated with bipolar I or II disorder in adults, as monotherapy and as adjunctive therapy with lithium or

596:) have also been found to possess efficacy in the treatment of bipolar depression as a monotherapy, whereas only olanzapine and quetiapine have been proven to be effective broad-spectrum (i.e., against all three types of relapse—manic, mixed and depressive) prophylactic (or 15051:

Heres S, Davis J, Maino K, Jetzinger E, Kissling W, Leucht S (February 2006). "Why olanzapine beats risperidone, risperidone beats quetiapine, and quetiapine beats olanzapine: an exploratory analysis of head-to-head comparison studies of second-generation antipsychotics".

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Antipsychotics in the nursing home population are often overprescribed, often for the purposes of making it easier to handle dementia patients. Federal efforts to reduce the use of antipsychotics in US nursing homes has led to a nationwide decrease in their usage in 2012.

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The majority of patients treated with an antipsychotic drug will experience a response within four weeks. The goals of continuing treatment are to maintain suppression of symptoms, prevent relapse, improve quality of life, and support engagement in psychosocial therapy.

1115:) repetitive, involuntary and purposeless movements, most often of the face, lips, legs, or torso, which tend to resist treatment and are frequently irreversible. The rate of appearance of TD is about 5% per year of use of antipsychotic drug (whatever the drug used) 1978:

class of atypical antipsychotics. Used primarily to treat bipolar disorder and schizophrenia. Also used and licensed in a few countries (including Australia, the United Kingdom and the United States) as an adjunct to antidepressant therapy in patients with

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Global antipsychotic utilization has seen a steady growth since the introduction of atypical (second-generation) antipsychotics and this is ascribed to off-label use for many other unapproved disorders. Besides the above uses antipsychotics may be used for

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It is recommended that persons with dementia who exhibit behavioral and psychological symptoms should not be given antipsychotics before trying other treatments. When taking antipsychotics this population has increased risk of cerebrovascular effects,

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randomized clinical trials, suggests that most patients who discontinue treatment do so because of suboptimal efficacy. If someone experiences psychotic symptoms due to nonadherence, they may be compelled to receive treatment through a process called

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to the older cheaper typicals that were out of patent. Following charges of illegal marketing, settlements by two large pharmaceutical companies in the US set records for the largest criminal fines ever imposed on corporations. One case involved

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Vermeir M, Naessens I, Remmerie B, Mannens G, Hendrickx J, Sterkens P, Talluri K, Boom S, Eerdekens M, van Osselaer N, Cleton A (April 2008). "Absorption, metabolism, and excretion of paliperidone, a new monoaminergic antagonist, in humans".

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The National Association of State Mental Health Program Directors said that antipsychotics are not interchangeable and it is recommend including trying at least one weight-neutral treatment for those patients with potential metabolic issues.

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and other extrapyramidal symptoms with the typicals and for this reason alone recommend first-line treatment with the atypicals, notwithstanding a greater propensity for metabolic adverse effects in the latter. The UK government organization

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Vieta E, Günther O, Locklear J, Ekman M, Miltenburger C, Chatterton ML, et al. (September 2011). "Effectiveness of psychotropic medications in the maintenance phase of bipolar disorder: a meta-analysis of randomized controlled trials".

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Goikolea JM, Colom F, Torres I, Capapey J, Valentí M, Undurraga J, Grande I, Sanchez-Moreno J, Vieta E (January 2013). "Lower rate of depressive switch following antimanic treatment with second-generation antipsychotics versus haloperidol".

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Tohen M, Greil W, Calabrese JR, Sachs GS, Yatham LN, Oerlinghausen BM, et al. (July 2005). "Olanzapine versus lithium in the maintenance treatment of bipolar disorder: a 12-month, randomized, double-blind, controlled clinical trial".

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Correll CU, Sheridan EM, DelBello MP (March 2010). "Antipsychotic and mood stabilizer efficacy and tolerability in pediatric and adult patients with bipolar I mania: a comparative analysis of acute, randomized, placebo-controlled trials".

11086:, another sedating second-generation antipsychotic, has also been misused for similar reasons. There is no standard treatment for antipsychotic abuse, though switching to a second-generation antipsychotic with less abuse potential (e.g., 930:(NMS) has been associated with the use of antipsychotics. Through its early recognition, and timely intervention rates have declined. However, an awareness of the syndrome is advised to enable intervention. Another less rare condition of 21609:

Janssen PA, Niemegeers CJ, Schellekens KH, Lenaerts FM, Verbruggen FJ, van Nueten JM, Marsboom RH, Hérin VV, Schaper WK (November 1970). "The pharmacology of fluspirilene (R 6218), a potent, long-acting and injectable neuroleptic drug".

1825:– An atypical antipsychotic of the benzamide chemical class used in Europe, Japan, and Hong Kong for the treatment of schizophrenia. It was launched by Sanofi-Aventis in 1976. Sultopride acts as a selective D2 and D3 receptor antagonist. 11105:

ministers it was reported that the needless use of antipsychotic medication in dementia care was widespread and was linked to 1800 deaths per year. In the US, the government has initiated legal action against the pharmaceutical company

482:(CBT). NICE further recommends that those expressing a preference for CBT alone be informed that combination treatment is more effective. A diagnosis of schizophrenia is not made at this time as it takes longer to be determined by both 14743:

Linton D, Barr AM, Honer WG, Procyshyn RM (May 2013). "Antipsychotic and psychostimulant drug combination therapy in attention deficit/hyperactivity and disruptive behavior disorders: a systematic review of efficacy and tolerability".

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Weisler RH, Nolen WA, Neijber A, Hellqvist A, Paulsson B (November 2011). "Continuation of quetiapine versus switching to placebo or lithium for maintenance treatment of bipolar I disorder (Trial 144: a randomized controlled study)".

868:) did better than the first-generation antipsychotic perphenazine on the measures used, nor did they produce fewer adverse effects than the typical antipsychotic perphenazine, although more patients discontinued perphenazine owing to 1319:

There is tentative evidence that discontinuation of antipsychotics can result in psychosis. It may also result in recurrence of the condition that is being treated. Rarely tardive dyskinesia can occur when the medication is stopped.

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Ishiyama T, Tokuda K, Ishibashi T, Ito A, Toma S, Ohno Y (October 2007). "Lurasidone (SM-13496), a novel atypical antipsychotic drug, reverses MK-801-induced impairment of learning and memory in the rat passive-avoidance test".

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Clinically used antipsychotic medications are listed below by drug group. Trade names appear in parentheses. A 2013 review has stated that the division of antipsychotics into first and second generation is perhaps not accurate.

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Teodoro T, Nogueira V, Aldeias J, Teles Martins M, Salgado J (September 2022). "Clozapine Associated Periorbital Edema in First Episode Psychosis: A Case Report of a Rare Adverse Effect in Treatment-Resistant Schizophrenia".

976:. A systematic review of clozapine-associated pulmonary embolism indicates that this adverse effect can often be fatal, and that it has an early onset, and is dose-dependent. The findings advised the consideration of using a 10991:

newer, more expensive atypicals, each costing on average $ 164 per year, compared to $ 40 for the older types. By 2008, sales in the US reached $ 14.6 billion, the biggest selling drugs in the US by therapeutic class.

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has been linked to psychotic experiences. Decreased dopamine release in the prefrontal cortex, and excess dopamine release in other pathways, are associated with psychotic episodes in schizophrenia and bipolar disorder.

14146:"Comparative effects of 18 antipsychotics on metabolic function in patients with schizophrenia, predictors of metabolic dysregulation, and association with psychopathology: a systematic review and network meta-analysis" 879:

Many researchers question the first-line prescribing of atypicals over typicals, and some even question the distinction between the two classes. In contrast, other researchers point to the significantly higher risk of

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Wen YG, Shang DW, Xie HZ, Wang XP, Ni XJ, Zhang M, Lu W, Qiu C, Liu X, Li FF, Li X, Luo FT (March 2013). "Population pharmacokinetics of blonanserin in Chinese healthy volunteers and the effect of the food intake".

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described it as controlling manic or psychotic agitation. The former claimed to have discovered a treatment for agitation in anyone, and the latter team claimed to have discovered a treatment for psychotic illness.

10903:. While popular during the 1950s, these terms are infrequently used today. They are being abandoned in favor of "antipsychotic", which refers to the drug's desired effects. Today, "minor tranquilizer" can refer to 15312:

Fischer-Barnicol D, Lanquillon S, Haen E, Zofel P, Koch HJ, Dose M, Klein HE (2008). "Typical and atypical antipsychotics--the misleading dichotomy. Results from the Working Group 'Drugs in Psychiatry' (AGATE)".

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in achieving the former goal, with first-generation and second generation antipsychotics showing about equal efficacy. The evidence that early treatment has a favorable effect on long-term outcomes is equivocal.

12564:"Antipsychotic Treatment Effectiveness in First Episode of Psychosis: PAFIP 3-Year Follow-Up Randomized Clinical Trials Comparing Haloperidol, Olanzapine, Risperidone, Aripiprazole, Quetiapine, and Ziprasidone" 11082:. In case reports, quetiapine has been abused in doses taken by mouth (which is how the drug is available from the manufacturer), but also crushed and insufflated or mixed with water for injection into a vein. 5373:

fashion. That is it rapidly dissociates from said receptor and hence produces antipsychotic effects but does not bind to the receptor long enough to produce extrapyramidal side effects and hyperprolactinaemia.

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Until the 1970s there was considerable debate within psychiatry on the most appropriate term to use to describe the new drugs. In the late 1950s the most widely used term was "neuroleptic", followed by "major

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reduction, an effect which is dose-dependent and time-dependent. A recent controlled trial suggests that second generation antipsychotics combined with intensive psychosocial therapy may potentially prevent

721:, while common, is not recommended as there is little evidence of benefit as well as concern regarding adverse effects. Some of the more serious adverse effects may also occur at the low doses used, such as 20413:

Cipriani A, Barbui C, Salanti G, Rendell J, Brown R, Stockton S, et al. (October 2011). "Comparative efficacy and acceptability of antimanic drugs in acute mania: a multiple-treatments meta-analysis".

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First-episode psychosis (FEP) is the first time that psychotic symptoms are presented. NICE recommends that all people presenting with first-episode psychosis be treated with both an antipsychotic drug and

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Harvey PD, Ogasa M, Cucchiaro J, Loebel A, Keefe RS (April 2011). "Performance and interview-based assessments of cognitive change in a randomized, double-blind comparison of lurasidone vs. ziprasidone".

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are often overlooked or confused with post-psychotic depression, in particular when they lack the extrapyramidal aspect that psychiatrists have been taught to expect when looking for signs of akathisia.

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Antipsychotics may be an option, together with stimulants, in people with ADHD and aggressive behavior when other treatments have not worked. They have not been found to be useful for the prevention of

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recently revised its recommendation favoring atypicals, to advise that the choice should be an individual one based on the particular profiles of the individual drug and on the patient's preferences.

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Withdrawal effects may also occur when switching a person from one antipsychotic to another, (it is presumed due to variations of potency and receptor activity). Such withdrawal effects can include

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appears to be more frequent with high-potency first-generation antipsychotics, such as haloperidol, and tends to appear after chronic and not acute treatment. It is characterized by slow (hence the

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receptors. Both clozapine and quetiapine appear to bind just long enough to elicit antipsychotic effects but not long enough to induce extrapyramidal side effects and prolactin hypersecretion. 5-HT

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McPheeters ML, Warren Z, Sathe N, Bruzek JL, Krishnaswami S, Jerome RN, Veenstra-Vanderweele J (May 2011). "A systematic review of medical treatments for children with autism spectrum disorders".

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Hálfdánarson Ó, Zoëga H, Aagaard L, Bernardo M, Brandt L, Fusté AC, Furu K, Garuoliené K, Hoffmann F, Huybrechts KF, Kalverdijk LJ, Kawakami K, Kieler H, Kinoshita T, Litchfield M (October 2017).

14371:"Prescribing of antipsychotics among people with recorded personality disorder in primary care: a retrospective nationwide cohort study using The Health Improvement Network primary care database" 373:. In this indication it is a common practice for the psychiatrist to prescribe a combination of an atypical antipsychotic and an antidepressant as this practice is best supported by the evidence. 13784: 11566:"Differentiating the effect of antipsychotic medication and illness on brain volume reductions in first-episode psychosis: A Longitudinal, Randomised, Triple-blind, Placebo-controlled MRI Study" 1404:‡ denotes drugs that are no longer (or were never to begin with) marketed in the United States. Some antipsychotics are not firmly placed in either first-generation or second-generation classes. 18124: 17753:

Nemeroff CB, Lieberman JA, Weiden PJ, Harvey PD, Newcomer JW, Schatzberg AF, Kilts CD, Daniel DG (November 2005). "From clinical research to clinical practice: a 4-year review of ziprasidone".

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Aringhieri S, Carli M, Kolachalam S, Verdesca V, Cini E, Rossi M, et al. (December 2018). "Molecular targets of atypical antipsychotics: From mechanism of action to clinical differences".

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please see Chopra et al 2021: Introduction, 3rd paragraph, Lieberman JA, et al. 2005 & Shao Y et al 2015, and Chopra et al: Are antipsychotics neuroprotective? 1st paragraph last sentence

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Maglione M, Maher AR, Hu J, Wang Z, Shanman R, Shekelle PG, Roth B, Hilton L, Suttorp MJ, Ewing BA, Motala A, Perry T (September 2011). "Off-Label Use of Atypical Antipsychotics: An Update".

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can occur due to long-term use of antipsychotics, developing after months or years of use. It is more often reported with use of typical antipsychotics. Very rarely antipsychotics may cause

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Paczynski RP, Alexander GC, Chinchilli VM, Kruszewski SP (January 2012). "Quality of evidence in drug compendia supporting off-label use of typical and atypical antipsychotic medications".

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Lehman AF, Lieberman JA, Dixon LB, McGlashan TH, Miller AL, Perkins DO, Kreyenbuhl J (February 2004). "Practice guideline for the treatment of patients with schizophrenia, second edition".

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Kinon BJ, Ascher-Svanum H, Adams DH, Chen L (October 2008). "The temporal relationship between symptom change and treatment discontinuation in a pooled analysis of 4 schizophrenia trials".

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Zuddas A, Zanni R, Usala T (August 2011). "Second generation antipsychotics (SGAs) for non-psychotic disorders in children and adolescents: a review of the randomized controlled studies".

2264:, which have dosages of several hundred milligrams. The latter have a greater degree of anticholinergic and antihistaminergic activity, which can counteract dopamine-related side-effects. 835:

may be more effective but are associated with greater side effects. Typical antipsychotics have equal drop-out and symptom relapse rates to atypicals when used at low to moderate dosages.

17469:

Moncrieff J (July 2006). "Does antipsychotic withdrawal provoke psychosis? Review of the literature on rapid onset psychosis (supersensitivity psychosis) and withdrawal-related relapse".

22072: 12398: 1252:

Some studies have found decreased life expectancy associated with the use of antipsychotics, and argued that more studies are needed. Antipsychotics may also increase the risk of early

838:

Clozapine is an effective treatment for those who respond poorly to other drugs ("treatment-resistant" or "refractory" schizophrenia), but it has the potentially serious side effect of

16471: 15526: 9935: 980:

after starting treatment with clozapine, and continuing this for six months. Constipation is three times more likely to occur with the use of clozapine, and severe cases can lead to

18563:

Silvestre JS, Prous J (June 2005). "Research on adverse drug events. I. Muscarinic M3 receptor binding affinity could predict the risk of antipsychotics to induce type 2 diabetes".

13544: 10781:) from the 1950s, reflecting the perceptions of psychosis, including the now-discredited perception of a tendency towards violence, from the time when antipsychotics were discovered 1344:. These adverse effects are more likely during rapid changes between antipsychotic agents, so making a gradual change between antipsychotics minimises these withdrawal effects. The 20559:

Popovic D, Reinares M, Goikolea JM, Bonnin CM, Gonzalez-Pinto A, Vieta E (May 2012). "Polarity index of pharmacological agents used for maintenance treatment of bipolar disorder".

10934:. The difference between first- and second-generation antipsychotics is a subject of debate. The second-generation antipsychotics are generally distinguishable by the presence of 2311:

antagonizing with normal amphetamine (with this just being hypothetical as there is the fact that antipsychotics sensitize receptors, with exact these postsynaptic receptors (5-HT

1121:: a systematic review and meta-analysis of observational studies with over 2 million individuals estimated an association between antipsychotic use and breast cancer by over 30%. 20295:

Fornaro P, Calabria G, Corallo G, Picotti GB (July 2002). "Pathogenesis of degenerative retinopathies induced by thioridazine and other antipsychotics: a dopamine hypothesis".

12908:"Comparative Efficacy and Safety of Long-acting Injectable and Oral Second-generation Antipsychotics for the Treatment of Schizophrenia: A Systematic Review and Meta-analysis" 17012:"The influence of chronic exposure to antipsychotic medications on brain size before and after tissue fixation: a comparison of haloperidol and olanzapine in macaque monkeys" 764:. Antipsychotics are only weakly recommended for Tourette syndrome, because although they are effective, side effects are common. The situation is similar for those on the 21404:

Prakash A, Lamb HM (January 1998). "Zotepine: A Review of its Pharmacodynamic and Pharmacokinetic Properties and Therapeutic Efficacy in the Management of Schizophrenia".

14244:"Comparative effects of pharmacological interventions for the acute and long-term management of insomnia disorder in adults: a systematic review and network meta-analysis" 12184:

Barnes TR (May 2011). "Evidence-based guidelines for the pharmacological treatment of schizophrenia: recommendations from the British Association for Psychopharmacology".

11843:

Leucht S, Corves C, Arbter D, Engel RR, Li C, Davis JM (January 2009). "Second-generation versus first-generation antipsychotic drugs for schizophrenia: a meta-analysis".

21637:

Beresford R, Ward A (January 1987). "Haloperidol decanoate. A preliminary review of its pharmacodynamic and pharmacokinetic properties and therapeutic use in psychosis".

17642:

Withdrawal of antipsychotic drugs after long-term therapy should always be gradual and closely monitored to avoid the risk of acute withdrawal syndromes or rapid relapse.

17418:

Withdrawal of antipsychotic drugs after long-term therapy should always be gradual and closely monitored to avoid the risk of acute withdrawal syndromes or rapid relapse.

14700:

Romeo R, Knapp M, Tyrer P, Crawford M, Oliver-Africano P (July 2009). "The treatment of challenging behaviour in intellectual disabilities: cost-effectiveness analysis".

10837:" and then "ataraxic". The first recorded use of the term tranquilizer dates from the early nineteenth century. In 1953 Frederik F. Yonkman, a chemist at the Swiss-based 22880:

Schneider LS, Tariot PN, Dagerman KS, Davis SM, Hsiao JK, Ismail MS, Lebowitz BD, Lyketsos CG, Ryan JM, Stroup TS, Sultzer DL, Weintraub D, Lieberman JA (October 2006).

17948:

Liemburg EJ, Knegtering H, Klein HC, Kortekaas R, Aleman A (June 2012). "Antipsychotic medication and prefrontal cortex activation: a review of neuroimaging findings".

12273:"Antipsychotics in adults with schizophrenia: comparative effectiveness of first-generation versus second-generation medications: a systematic review and meta-analysis" 361:(in the case of the bipolar subtype). Antipsychotics possess mood stabilizing properties and thus they may be used as standalone medication to treat mood dysregulation. 20792:

Kishi T, Iwata N (September 2013). "Efficacy and tolerability of perospirone in schizophrenia: a systematic review and meta-analysis of randomized controlled trials".

11173:, the company's antipsychotic drug. Biederman has responded saying that the money did not influence him and that he did not promote a specific diagnosis or treatment. 22139: 15928:

Sarvaiya N, Lapitskaya Y, Dima L, Manu P (August 2018). "Clozapine-Associated Pulmonary Embolism: A High-Mortality, Dose-Independent and Early-Onset Adverse Effect".

1928:(Saphris) – Of the dibenzo-oxepino pyrrole class of atypical antipsychotics. Used for the treatment of schizophrenia and acute mania associated with bipolar disorder. 25572: 21515:

Ereshefsky L, Saklad SR, Jann MW, Davis CM, Richards A, Seidel DR (May 1984). "Future of depot neuroleptic therapy: pharmacokinetic and pharmacodynamic approaches".

780:

have been approved by the US FDA for the treatment of irritability in autistic children and adolescents. A review in the UK found that the use of antipsychotics in

22535: 15469: 13179:

Tohen M, Katagiri H, Fujikoshi S, Kanba S (July 2013). "Efficacy of olanzapine monotherapy in acute bipolar depression: a pooled analysis of controlled studies".

11971: 22212: 4357:. Dose-dependent seizure risk. Overall the most effective antipsychotic, on average. Usually reserved for treatment-resistant cases or highly suicidal patients. 1868:(Risperdal) – Divided dosing is recommended until initial titration is completed, at which time the drug can be administered once daily. Used off-label to treat 27466: 24844: 21897:"British Association for Psychopharmacology consensus statement on evidence-based treatment of insomnia, parasomnias and circadian rhythm disorders: An update" 19926:"Auditing clinical outcomes after introducing off-licence prescribing of atypical antipsychotic melperone for patients with treatment refractory schizophrenia" 20459:"Addressing the need for rapid treatment of agitation in schizophrenia and bipolar disorder: focus on inhaled loxapine as an alternative to injectable agents" 2001:

class of atypical antipsychotic indicated for acute and chronic schizophrenia. It is still used in Japan and was once used in Germany but it was discontinued.

24738: 23818: 22745: 22494: 22297: 15281:"How CATIE brought us back to Kansas: a critical re-evaluation of the concept of atypical antipsychotics and their place in the treatment of schizophrenia" 22371: 19611:

Isbister GK, Balit CR, Macleod D, Duffull SB (August 2010). "Amisulpride overdose is frequently associated with QT prolongation and torsades de pointes".

17903:

Pickar D, Litman RE, Konicki PE, Wolkowitz OM, Breier A (1990). "Neurochemical and Neural Mechanisms of Positive and Negative Symptoms in Schizophrenia".

11101:

has argued that antipsychotic drug treatment is often undertaken as a means of control rather than to treat specific symptoms experienced by the patient.

21440:

Parent M, Toussaint C, Gilson H (1983). "Long-term treatment of chronic psychotics with bromperidol decanoate: clinical and pharmacokinetic evaluation".

20648:

Komossa K, Depping AM, Gaudchau A, Kissling W, Leucht S (December 2010). "Second-generation antipsychotics for major depressive disorder and dysthymia".

15542:

Stahl SM, Grady MM (February 2004). "A critical review of atypical antipsychotic utilization: comparing monotherapy with polypharmacy and augmentation".

15095:

Lieberman JA, Stroup TS, McEvoy JP, Swartz MS, Rosenheck RA, Perkins DO, Keefe RS, Davis SM, Davis CE, Lebowitz BD, Severe J, Hsiao JK (September 2005).

14335: 13682:

Komossa K, Depping AM, Gaudchau A, Kissling W, Leucht S (December 2010). "Second-generation antipsychotics for major depressive disorder and dysthymia".

13773: 12515:"A Randomized Comparison of Aripiprazole and Risperidone for the Acute Treatment of First-Episode Schizophrenia and Related Disorders: 3-Month Outcomes" 536:, in which they can be forced to accept treatment (including antipsychotics). A person can also be committed to treatment outside of a hospital, called 18233:"Prolonged Amphetamine Exposures Increase the Endogenous Human Dopamine Receptors 2 at the Cellular Membrane in Cells Lacking the Dopamine Transporter" 18109: 22819: 17539:

Nakata Y, Kanahara N, Iyo M (December 2017). "Dopamine supersensitivity psychosis in schizophrenia: Concepts and implications in clinical practice".

16873:"Association of antipsychotic use with breast cancer: a systematic review and meta-analysis of observational studies with over 2 million individuals" 15623:

Nakata Y, Kanahara N, Iyo M (December 2017). "Dopamine supersensitivity psychosis in schizophrenia: Concepts and implications in clinical practice".

886: 742: 612: 23786: 10793:. It was first used on psychiatric patients because of its powerful calming effect; at the time it was regarded as a non-permanent "pharmacological 5647:

Dose-dependent risk for degenerative retinopathies. Found utility in reducing the resistance of multidrug and even extensively resistant strains of

4858:

Withdrawn from the market. Seems to promote weight loss (which is rather unusual for an antipsychotic seeing how they tend to promote weight gain).

26668: 25095: 21831:

Healy D (2008). "The Intersection of Psychopharmacology and Psychiatry in the Second Half of the Twentieth Century". In Wallace ER, Gach J (eds.).

21001:"Active metabolites as antidepressant drugs: the role of norquetiapine in the mechanism of action of quetiapine in the treatment of mood disorders" 12713:

Beitinger R, Lin J, Kissling W, Leucht S (October 2008). "Comparative remission rates of schizophrenic patients using various remission criteria".

1247: 437: 248: 22847:"Efficacy and comparative effectiveness of atypical antipsychotic medications for off-label uses in adults: a systematic review and meta-analysis" 18894:

Geller V, Gorzaltsan I, Shleifer T, Belmaker RH, Bersudsky Y (December 2005). "Clotiapine compared with chlorpromazine in chronic schizophrenia".

16558:"Pancreatitis associated with atypical antipsychotics: from the Food and Drug Administration's MedWatch surveillance system and published reports" 1807:

and, hence, has been withdrawn from the market worldwide. It has also been found to possess relatively low (virtually absent) potential to induce

600:) treatments in patients with bipolar disorder. A recent Cochrane review also found that olanzapine had a less favourable risk/benefit ratio than 26049: 25316: 24795: 23028: 22811: 16736: 12229:"Pharmacological treatment of schizophrenia: a critical review of the pharmacology and clinical effects of current and future therapeutic agents" 448:

of psychosis, that include delusions and hallucinations. There is mixed evidence to support a significant impact of antipsychotic use on primary

13715:"Adjunctive atypical antipsychotic treatment for major depressive disorder: a meta-analysis of depression, quality of life, and safety outcomes" 26743: 26638: 25999: 25382: 22985: 21707:

Larsson M, Axelsson R, Forsman A (1984). "On the pharmacokinetics of perphenazine: a clinical study of perphenazine enanthate and decanoate".

21361:

Wiesel FA, Alfredsson G, Ehrnebo M, Sedvall G (May 1980). "The pharmacokinetics of intravenous and oral sulpiride in healthy human subjects".

17654: 12394: 293:

as well. Third-generation antipsychotics were introduced in the 2000s and offer partial agonism, rather than blockade, of dopamine receptors.

26608: 26435: 25346: 25240: 20873:

Shahid M, Walker GB, Zorn SH, Wong EH (January 2009). "Asenapine: a novel psychopharmacologic agent with a unique human receptor signature".

16050:

Sriretnakumar V, Huang E, Müller DJ (2015). "Pharmacogenetics of clozapine treatment response and side-effects in schizophrenia: an update".

21672:

Reyntigens AJ, Heykants JJ, Woestenborghs RJ, Gelders YG, Aerts TJ (1982). "Pharmacokinetics of haloperidol decanoate. A 2-year follow-up".

16971:"Multimodal meta-analysis of structural and functional brain changes in first episode psychosis and the effects of antipsychotic medication" 15520: 10853:

was coined in 1955 by Delay and Deniker after their discovery (1952) of the antipsychotic effects of chlorpromazine. It is derived from the

26285: 26244: 26194: 26139: 25130: 25110: 24927: 18939:"Preclinical and clinical pharmacology of cyamemazine: anxiolytic effects and prevention of alcohol and benzodiazepine withdrawal syndrome" 22552:

American Psychiatric Association (2006). "Practice Guideline for the Treatment of Patients with Alzheimer's Disease and Other Dementias".

22338: 22224: 14617: 25372: 23808: 18441: 15767: 11270: 941:

Clozapine is associated with side effects that include weight gain, tiredness, and hypersalivation. More serious adverse effects include

21881: 11169:

gave more than $ 700,000 to a research center that was headed by Biederman from 2002 to 2005, where research was conducted, in part, on

26688: 25392: 24953: 24837: 24589: 23001: 19272:

Roelofs GA (1974). "Penfluridol (R 16341) as a maintenance therapy in chronic psychotic patients: a double-blind clinical evaluation".

15703:"Tardive dyskinesia risk with first- and second-generation antipsychotics in comparative randomized controlled trials: a meta-analysis" 14549: 10999:

is spending an additional £33 million annually on antipsychotics. Haloperidol 500 microgram tablets constituted £14.3 million of this.

1084:

Weight gain (particularly prominent with clozapine, olanzapine, quetiapine and zotepine, can be counteracted by starting the drug with

733:. Despite the lack of evidence supporting the benefit of antipsychotics in people with personality disorders, 1 in 4 who do not have a 24549: 23013: 18184:"Antipsychotic-induced sensitization and tolerance: Behavioral characteristics, developmental impacts, and neurobiological mechanisms" 13562: 10820:

described chlorpromazine only as inducing indifference towards what was happening around them in nonpsychotic, nonmanic patients, and

784:

doubled between 2000 and 2019. Children were prescribed antipsychotics for conditions for which there is no approval, such as autism.

25632: 25074: 25020: 22995: 22416: 16263:"Metformin co-commencement at time of antipsychotic initiation for attenuation of weight gain: a systematic review and meta-analysis" 16142:

Adam RL, Sidi H, Midin M, et al. (2018). "The Role of Atypical Antipsychotics in Sexuality: Road to Recovery in Schizophrenia".

14553: 10920: 19700: 19698: 14461:

Pringsheim T, Doja A, Gorman D, McKinlay D, Day L, Billinghurst L, Carroll A, Dion Y, Luscombe S, Steeves T, Sandor P (March 2012).

26948: 26899: 26855: 26763: 23067: 12562:

Gómez-Revuelta M, Pelayo-Terán JM, Juncal-Ruiz M, Vázquez-Bourgon J, Suárez-Pinilla P, Romero-Jiménez R, et al. (April 2020).

12314:"Initial severity of schizophrenia and efficacy of antipsychotics: participant-level meta-analysis of 6 placebo-controlled studies" 2256:, in general, have doses of a few milligrams and cause less sleepiness and calming effects than low-potency antipsychotics such as 21462:

Jørgensen A, Overø KF (1980). "Clopenthixol and flupenthixol depot preparations in outpatient schizophrenics. III. Serum levels".

17061:"Principles of antipsychotic prescribing for policy makers, circa 2008. Translating knowledge to promote individualized treatment" 16773: 273:, were first introduced in the 1950s, and others were developed until the early 1970s. Second-generation antipsychotics, known as 27021: 26819: 19695: 17609:

Lambert TJ (2007). "Switching antipsychotic therapy: what to expect and clinical strategies for improving therapeutic outcomes".

11176:

Pharmaceutical companies have also been accused of attempting to set the mental health agenda through activities such as funding

5114:

Usually grouped with the atypical antipsychotics despite its relatively high propensity for causing extrapyramidal side effects.

376: 21116: 13074: 27252: 26837: 26828: 25170: 25165: 11206: 407: 22213:

https://www.npr.org/sections/health-shots/2018/02/05/583435517/risky-antipsychotic-drugs-still-overprescribed-in-nursing-homes

16603:

Weinmann S, Read J, Aderhold V (August 2009). "Influence of antipsychotics on mortality in schizophrenia: systematic review".

16499:"Alterations to melanocortinergic, GABAergic and cannabinoid neurotransmission associated with olanzapine-induced weight gain" 10890: 24830: 24162: 23752: 22569: 22054: 22028: 21980: 21951: 21875: 21848: 21741:"The introduction of chlorpromazine in Belgium and the Netherlands (1951–1968); tango between old and new treatment features" 21239:

Callaghan JT, Bergstrom RF, Ptak LR, Beasley CM (September 1999). "Olanzapine. Pharmacokinetic and pharmacodynamic profile".

20780: 19595: 19570: 19545: 19518: 19491: 19464: 19431: 19256: 19220: 19154: 19103: 19067: 18997: 18874: 18783: 18753: 18726: 18690: 18660: 18498: 18466: 18435: 18158: 17924: 17523: 17450: 17411: 16481: 15761: 15502: 14312: 13917:"On- and off-label utilisation of antipsychotics in Australia (2000–2021): Retrospective analysis of two medication datasets" 13396:

Cipriani A, Rendell JM, Geddes J (January 2009). Cipriani A (ed.). "Olanzapine in long-term treatment for bipolar disorder".

13022: 11942: 11264: 10938:

antagonism and a corresponding lower propensity for extrapyramidal side effects compared to first-generation antipsychotics.

2307:

exposure can be more intense because it has more excitatory receptors to activate. The same effect can be observed with the D

1896:(Latuda) – Approved by the US FDA for schizophrenia and bipolar depression, and for use as schizophrenia treatment in Canada. 18880: 18029:

Schmidt CJ, Sorensen SM, Kehne JH, Carr AA, Palfreyman MG (1995). "The role of 5-HT2A receptors in antipsychotic activity".

16922:"Progressive loss of cortical gray matter in schizophrenia: a meta-analysis and meta-regression of longitudinal MRI studies" 1316:

may be a feeling of the world spinning, numbness, or muscle pains. Symptoms generally resolve after a short period of time.

876:

Atypical antipsychotics do not appear to lead to improved rates of medication adherence compared to typical antipsychotics.

799:

and recommended that the use of antipsychotics in this way should no longer be regarded as an acceptable routine treatment.

24449: 24442: 10808:

The discovery of chlorpromazine's psychoactive effects in 1952 led to further research that resulted in the development of

1681:

This category is for drugs that have been called both first and second-generation, depending on the literature being used.

22163:"Inappropriate long-term use of antipsychotic drugs is common among people with dementia living in specialized care units" 17868:

Swainston Harrison T, Perry CM (2004). "Aripiprazole: a review of its use in schizophrenia and schizoaffective disorder".

14653:"Trends in antipsychotic prescribing to children and adolescents in England: cohort study using 2000-19 primary care data" 10785:

The original antipsychotic drugs were happened upon largely by chance and then tested for their effectiveness. The first,

2204:

In addition to the antagonistic effects of dopamine, antipsychotics (in particular atypical neuroleptics) also antagonize

2074:

antagonism of second-generation (atypical) antipsychotics and D2 antagonism of first-generation (typical) antipsychotics.

640:. An assessment for an underlying cause of behavior is needed before prescribing antipsychotic medication for symptoms of 27064: 26846: 23007: 21064: 16015:

Citrome L, McEvoy JP, Saklad SR (2016). "Guide to the Management of Clozapine-Related Tolerability and Safety Concerns".

2220:

receptor have been associated with schizophrenia and other psychoses, including depression. Higher concentrations of 5-HT

1324: 853: 23016:– Public Health Advisory for Antipsychotic Drugs used for Treatment of Behavioral Disorders in Elderly Patients, fda.gov 22390: 13157: 490:, and only around 60% of those presenting with a first episode of psychosis will later be diagnosed with schizophrenia. 24192: 24055: 22517: 20850:. University of North Carolina at Chapel Hill and the United States National Institute of Mental Health. Archived from 15451: 12355:"The effects of atypical antipsychotic drugs on neurocognitive impairment in schizophrenia: a review and meta-analysis" 11963: 22845:

Maher AR, Maglione M, Bagley S, Suttorp M, Hu JH, Ewing B, Wang Z, Timmer M, Sultzer D, Shekelle PG (September 2011).

13311:"Maintenance treatment of adolescent bipolar disorder: open study of the effectiveness and tolerability of quetiapine" 1135:

Blood dyscrasias (e.g., agranulocytosis, leukopenia, and neutropaenia), which is more common in patients on clozapine.

27461: 27388: 27153: 23816: 23039: 22004: 9551: 1988: 714: 686: 23019: 21896: 21740: 1206:

prolongation — more prominent in those treated with amisulpride, pimozide, sertindole, thioridazine and ziprasidone.

1050:, symptoms that are similar to what people with Parkinson's disease experience, including tremulousness and drooling 772:

found that 16.5% were taking an antipsychotic drug, most commonly for irritability, aggression, and agitation. Both

23769: 22531: 22513: 21088: 21083: 17253:

MacKenzie NE, Kowalchuk C, Agarwal SM, Costa-Dookhan KA, Caravaggio F, Gerretsen P, et al. (5 December 2018).

15465: 15447: 13587:"The effectiveness of atypical antipsychotics for the treatment of aggression and psychosis in Alzheimer's disease" 11408:

Antipsychotic medications are mainstays in the treatment of schizophrenia and a range of other psychotic disorders.

769: 757: 608: 441: 22731: 22554:

APA Practice Guidelines for the Treatment of Psychiatric Disorders: Comprehensive Guidelines and Guideline Watches

11518:

Moncrieff J, Leo J (September 2010). "A systematic review of the effects of antipsychotic drugs on brain volume".

26228: 25259: 24345: 23801: 23031:

Fifty Years of Antipsychotic Drugs in Psychiatry. "Cinqüenta Anos de Medicamentos Antipsicóticos em Psiquiatria."

22764:"American Geriatrics Society updated Beers Criteria for potentially inappropriate medication use in older adults" 16689:"American Geriatrics Society updated Beers Criteria for potentially inappropriate medication use in older adults" 12821:"20-Year Nationwide Follow-Up Study on Discontinuation of Antipsychotic Treatment in First-Episode Schizophrenia" 4054:

Amoxapine is also an antidepressant. Very toxic in overdose due to the potential for renal failure and seizures.

1934:(Clozaril) – Of the dibenzodiazepine class of atypical antipsychotics. Requires routine laboratory monitoring of 815:

Aside from reduced extrapyramidal symptoms, and with the clear exception of clozapine, it is unclear whether the

730: 444:, and the British Society for Psychopharmacology. The main aim of treatment with antipsychotics is to reduce the 17306:"Antipsychotic use in dementia: the relationship between neuropsychiatric symptom profiles and adverse outcomes" 11993:

Budman CL (July 2014). "The role of atypical antipsychotics for treatment of Tourette's syndrome: an overview".

1323:

Unexpected psychotic episodes have been observed in patients withdrawing from clozapine. This is referred to as

26864: 22937:"Drug-induced supersensitivity psychosis revisited: characteristics of relapse in treatment-compliant patients" 22320: 18284:"Involvement of 5-HT2A receptors in MDMA reinforcement and cue-induced reinstatement of MDMA-seeking behaviour" 16969:

Radua J, Borgwardt S, Crescini A, Mataix-Cols D, Meyer-Lindenberg A, McGuire PK, Fusar-Poli P (November 2012).

16419: 12474:"Rates and Predictors of Conversion to Schizophrenia or Bipolar Disorder Following Substance-Induced Psychosis" 12139: 1171: 927: 907:

Generally, more than one antipsychotic drug should not be used at a time because of increased adverse effects.

901: 690: 22825:

Dementia: Supporting people with dementia and their carers in health and social care Clinical guidelines, CG42

21138: 20839: 19831:

Chakrabarti A, Bagnall A, Chue P, Fenton M, Palaniswamy V, Wong W, Xia J (October 2007). Chakrabarti A (ed.).

15882:

Kritharides L, Chow V, Lambert TJ (6 February 2017). "Cardiovascular disease in patients with schizophrenia".

15399:

Makhinson M (January 2010). "Biases in medication prescribing: the case of second-generation antipsychotics".

11032:

They may be administered orally or, in some cases, through long-acting (depot) injections administered in the

705:

and agitation in those with dementia. Evidence however does not support the use of atypical antipsychotics in

624:

Psychosis and agitation develop in as many as 80 percent of people living in nursing homes. Despite a lack of

212:. Moreover, they are also used as adjuncts in the treatment of treatment-resistant major depressive disorder. 27471: 27193: 15201:

Voruganti LP, Baker LK, Awad AG (March 2008). "New generation antipsychotic drugs and compliance behaviour".

10878: 1014:

Sedation (particularly common with asenapine, clozapine, olanzapine, quetiapine, chlorpromazine and zotepine)

316: 21547:"Kinetics of fluphenazine after fluphenazine dihydrochloride, enanthate and decanoate administration to man" 19659:

Deeks ED, Keating GM (January 2010). "Blonanserin: a review of its use in the management of schizophrenia".

17155:"Influence of Antipsychotic and Anticholinergic Loads on Cognitive Functions in Patients with Schizophrenia" 13763:

Truven Health Analytics, Inc. DrugPoint System (Internet) . Greenwood Village, CO: Thomsen Healthcare; 2013.

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Patrick V, Levin E, Schleifer S (July 2005). "Antipsychotic polypharmacy: is there evidence for its use?".

12955: 10765: 3927: 1353: 749: 661: 625: 479: 415: 286: 22829: 15786:"Safety of antipsychotics for the treatment of schizophrenia: a focus on the adverse effects of clozapine" 15666:

Ware MR, Feller DB, Hall KL (4 January 2018). "Neuroleptic Malignant Syndrome: Diagnosis and Management".

14607:

Truven Health Analytics, Inc. DRUGDEX System (Internet) . Greenwood Village, CO: Thomsen Healthcare; 2013.

11468:"Long-term antipsychotic treatment and brain volumes: a longitudinal study of first-episode schizophrenia" 460:

therapeutic benefit and prevent symptom relapse); and treatment of recurrent episodes of acute psychosis.

27402: 27173: 27001: 24655: 22727: 21092: 13101:"Cariprazine Treatment of Bipolar Depression: A Randomized Double-Blind Placebo-Controlled Phase 3 Study" 12085:

Kreys TJ, Phan SV (February 2015). "A literature review of quetiapine for generalized anxiety disorder".

10860: 2196:. This means that dopamine released in these pathways has less effect. Excess release of dopamine in the 1029: 792: 304: 17: 22459:

Gosden R, Beder S (1 January 2001). "Pharmaceutical industry agenda setting in mental health policies".

14242:

De Crescenzo F, D'Alò GL, Ostinelli EG, Ciabattini M, Di Franco V, Watanabe N, et al. (July 2022).

11052:

formulation of an antipsychotic (transdermal asenapine, marketed as Secuado), was FDA-approved in 2019.

892:

The re-evaluation of the evidence has not necessarily slowed the bias toward prescribing the atypicals.

27163: 26133: 25234: 24305: 23794: 22225:

https://pharmaceutical-journal.com/article/opinion/atypical-antipsychotics-overrated-and-overprescribed

21196:

Borgström L, Larsson H, Molander L (1982). "Pharmacokinetics of parenteral and oral melperone in man".

20510:"Efficacy of modern antipsychotics in placebo-controlled trials in bipolar depression: a meta-analysis" 12613:"How effective are second-generation antipsychotic drugs? A meta-analysis of placebo-controlled trials" 12312:

Furukawa TA, Levine SZ, Tanaka S, Goldberg Y, Samara M, Davis JM, Cipriani A, Leucht S (January 2015).

4771:

May be particularly helpful in ameloriating the cognitive symptoms of schizophrenia, likely due to its

3891: 2236: 1311: 1304: 21598:. 19th Annual Midyear Clinical Meeting of the American Society of Hospital Pharmacists. Dallas, Texas. 17582:

Glazer WM (2000). "Expected incidence of tardive dyskinesia associated with atypical antipsychotics".

15144:

Swartz MS, Stroup TS, McEvoy JP, Davis SM, Rosenheck RA, Keefe RS, Hsiao JK, Lieberman JA (May 2008).

2319:) being flooded by the respective neurotransmitter (serotonine, dopamine) from amphetamine exposure). 1815:, likely attributable to its comparatively weak binding to (and, hence, rapid dissociation from) the D 27368: 26991: 23713: 22998:, Australian Prescriber 2005 (note: pharmaceutical company conflict of interest statement at the end) 22989: 21318:

DeVane CL, Nemeroff CB (2001). "Clinical pharmacokinetics of quetiapine: an atypical antipsychotic".

20095: 19756: 19454: 14336:"Antipsychotics are commonly prescribed to people with personality disorders, contrary to guidelines" 13017:(9th ed.). Philadelphia: Wolters Kluwer Health/Lippincott Williams & Wilkins. p. 3040. 10801:

involved has since been studied in detail, and subsequent antipsychotic drugs have been developed by

10736: 2248: 1984: 1980: 1142: 1091:

Anticholinergic side-effects (common for olanzapine, clozapine; less likely on risperidone) such as:

653: 20387: 19979: 17122: 14936: 14082:. Comparative Effectiveness Reviews, No. 43. Rockville: Agency for Healthcare Research and Quality. 1260:. Antipsychotics typically worsen symptoms in people with depersonalisation disorder. Antipsychotic 652:

A number of atypical antipsychotics have some benefits when used in addition to other treatments in

27183: 27158: 27037: 27016: 23401: 23302: 23042:, File .pdf (Adobe Acrobat) 6Mb, Informática, Rio de Janeiro, August 2003, 486pp., medicina.ufrj.br 22761: 16686: 15516: 11177: 11125: 10838: 10732: 10557: 10044: 1952:

class of atypical antipsychotics. Used to treat psychotic disorders including schizophrenia, acute

856:

published the results of a major independent study (the CATIE project). No other atypical studied (

350: 138: 91: 16832:"Polypharmacy and excessive dosing: psychiatrists' perceptions of antipsychotic drug prescription" 16357: 15835:"Genetics of clozapine-associated neutropenia: recent advances, challenges and future perspective" 15146:"Special Section on Implications of CATIE: What CATIE Found: Results From the Schizophrenia Trial" 27456: 27069: 26885: 25652: 24360: 24038: 23889: 23757: 23165: 23053: 22579:

Aparasu RR, Bhatara V (December 2006). "Antipsychotic use and expenditure in the United States".

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14078:

Maglione M, Maher AR, Hu J, Wang Z, Shanman R, Shekelle PG, Roth B, Hilton L, Suttorp MJ (2011).

11211: 11194: 10816:, and the majority of other drugs now used in the management of psychiatric conditions. In 1952, 10706: 10665: 5932: 4014: 3911: 1983:. It's the only antipsychotic that's demonstrated efficacy as a monotherapy for the treatment of 1812: 1788: 919: 869: 849:

Due to bias in the research the accuracy of comparisons of atypical antipsychotics is a concern.

788: 761: 633: 228: 1850:

were very common side effects. Has not received regulatory approval in other countries, however.

453: 27373: 27310: 27135: 27011: 26038: 25214: 24397: 24152: 23665: 23569: 23536: 23516: 23396: 23367: 23280: 23275: 23238: 23233: 19535: 19508: 18773: 18743: 18141:

Meltzer HY (2012). "Serotonergic Mechanisms as Targets for Existing and Novel Antipsychotics".

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Robinson DG, Gallego JA, John M, Petrides G, Hassoun Y, Zhang JP, et al. (November 2015).

11017: 10931: 10602: 10483: 10446: 10417: 10409: 10374: 10345: 10229: 10192: 10052: 10015: 8572: 4818: 3202: 2296:, leading to a lowered extrapyramidal side effect liability among the atypical antipsychotics. 2267: 2231:

Typical antipsychotics are not particularly selective and also block dopamine receptors in the

2025: 1761: 1177:

Autonomic instability, which can manifest with tachycardia, nausea, vomiting, diaphoresis, etc.

1165: 816: 734: 533: 494: 449: 445: 403: 274: 270: 177: 22044: 21968: 19246: 18716: 18456: 18425: 17440: 15751: 14959:

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11254: 452:(such as apathy, lack of emotional affect, and lack of interest in social interactions) or on 26968: 26384: 25658: 25325: 24082: 24018: 23863: 23621: 23379: 23297: 23130: 23113: 23089: 22805: 22488: 21865: 19093: 18488: 17513: 17206:"Antipsychotic use in dementia: a systematic review of benefits and risks from meta-analyses" 16730: 14026:"Summary of the comparative effectiveness review on off-label use of atypical antipsychotics" 13543: 11564:

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Earley W, Burgess MV, Rekeda L, Dickinson R, Szatmári B, Németh G, et al. (June 2019).

12289: 12272: 11230:

Bolded drug names indicate drugs that are metabolites of clinically-marketed antipsychotics.

11078:) "hallucinogenic" effects. The most commonly implicated second-generation antipsychotic is 993:

associated with beneficial effects on sexual functioning helped by various psychotherapies.

204:

but also in a range of other psychotic disorders. They are also the mainstay, together with

27430: 27415: 27315: 27247: 27235: 27125: 26633: 25844: 25115: 24157: 24137: 24006: 22425: 17797: 17640:(57 ed.). United Kingdom: Royal Pharmaceutical Society of Great Britain. p. 192. 17406:(57 ed.). United Kingdom: Royal Pharmaceutical Society of Great Britain. p. 192. 16510: 15494: 14545: 14195:"Dose-dependent effects of antipsychotics on efficacy and adverse effects in schizophrenia" 13548: 11731:"Third generation antipsychotic drugs: partial agonism or receptor functional selectivity?" 11166: 11106: 11075: 11061: 8564: 8556: 8542: 5362: 4128: 2232: 1949: 1935: 1862:– Has a higher incidence of extrapyramidal side effects than other atypical antipsychotics. 656:. Aripiprazole, quetiapine extended-release, and olanzapine (when used in conjunction with 601: 570: 566: 370: 22441: 20781:

https://www.has-sante.fr/upload/docs/application/pdf/2012-04/anti_psychotiques_rapport.pdf

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Antipsychotics are sometimes administered as part of compulsory psychiatric treatment via

215:

Use of any antipsychotic is associated with reductions in brain tissue volumes, including

8: 27353: 27168: 27006: 26938: 26773: 25506: 25145: 24948: 24766: 24502: 24288: 24067: 23894: 22670:"Psychosocial interventions for reducing antipsychotic medication in care home residents" 22395: 22140:"Data show 'spiralling' antipsychotic price increases of up to 1,200% in past five years" 22120:

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Explaining the pharmacokinetics of fluphenazine through computer simulations. (Abstract.)

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Some atypicals are associated with considerable weight gain, diabetes and the risk of

27320: 27266: 27084: 26983: 26703: 26561: 24853: 24806: 24761: 24544: 24534: 24437: 24267: 24223: 24207: 24011: 24001: 23944: 23934: 23035: 22966: 22903: 22868: 22793: 22779: 22699: 22656: 22639: 22596: 22565: 22476: 22269: 22194: 22102: 22050: 22024: 22000: 21976: 21947: 21928: 21916: 21871: 21844: 21760: 21689: 21654: 21650: 21619: 21576: 21524: 21479: 21417: 21378: 21335: 21331: 21292: 21256: 21252: 21213: 21170: 21032: 20973: 20937: 20902: 20890: 20809: 20763: 20712: 20661: 20630: 20576: 20541: 20508:

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19676: 19672: 19640: 19628: 19591: 19566: 19541: 19514: 19487: 19460: 19387: 19342: 19289: 19252: 19128: 19099: 19045: 19033: 19029: 18993: 18968: 18911: 18870: 18843: 18816: 18779: 18749: 18722: 18580: 18494: 18462: 18431: 18315: 18264: 18213: 18164: 18154: 18087: 18046: 18042: 18011: 17965: 17930: 17920: 17885: 17881: 17825: 17817: 17770: 17739: 17727: 17723: 17618: 17591: 17556: 17519: 17486: 17482: 17446: 17407: 17384: 17335: 17286: 17235: 17186: 17135: 17090: 17045: 17033: 16992: 16951: 16902: 16853: 16804: 16800: 16718: 16704: 16669: 16620: 16577: 16538: 16477: 16439: 16392: 16335: 16294: 16243: 16229: 16214:"Metformin for olanzapine-induced weight gain: a systematic review and meta-analysis" 16194: 16159: 16124: 16079: 16067: 16032: 16001: 15989: 15945: 15899: 15864: 15815: 15757: 15732: 15683: 15640: 15605: 15559: 15498: 15416: 15373: 15330: 15261: 15218: 15183: 15165: 15118: 15069: 15033: 14976: 14941: 14900: 14859: 14810: 14761: 14717: 14713: 14686: 14674: 14637: 14519: 14484: 14435: 14400: 14355: 14308: 14304:

Practice Guideline for the Treatment of Patients With Borderline Personality Disorder

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First marketed antipsychotic, sort of the prototypical low-potency first-generation (

2181: 2063: 2052: 1975: 1942:. It has unparalleled efficacy in the treatment of treatment-resistant schizophrenia. 1869: 1146: 935: 791:

is often treated with antipsychotic drugs despite lack of an evidence base. A recent

698: 395: 383:

Given the limited options available to treat the behavioral problems associated with

99: 22882:"Effectiveness of atypical antipsychotic drugs in patients with Alzheimer's disease" 22711: 21390: 21347: 21225: 21182: 20985: 20821: 20572: 20443: 20324: 19688: 19301: 18923: 17977: 17961: 17782: 17255:"Antipsychotics, Metabolic Adverse Effects, and Cognitive Function in Schizophrenia" 16987: 16970: 16816: 16589: 16451: 16404: 16171: 15957: 15428: 15385: 15130: 14988: 14845: 14789:"Antipsychotics for Preventing Delirium in Hospitalized Adults: A Systematic Review" 14773: 14729: 14431: 13875: 13295: 13134: 13013:

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American Geriatrics Society 2012 Beers Criteria Update Expert Panel (April 2012).

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American Geriatrics Society 2012 Beers Criteria Update Expert Panel (April 2012).

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serotonin pathways enabling a sensitisation of postsynaptic serotonin receptors,

2282: 2275: 2225: 1939: 1838:(Fanapt) – Approved by the US FDA in 2009, it is fairly well tolerated, although 1650: 1627: 1622: 1606: 1546: 1220: 1190: 961: 950: 839: 765: 706: 672: 562: 544: 358: 205: 144: 107: 23080: 22357: 21756: 18799:

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receptors and perhaps by interacting with other neurochemical pathways in the

27450: 27425: 27383: 27378: 27220: 27210: 27091: 26973: 26908: 26748: 26663: 26623: 26496: 26315: 26239: 26199: 26179: 26079: 25824: 25673: 25668: 25611: 25562: 25491: 25296: 25058: 24994: 24722: 24695: 24372: 24283: 24263: 24259: 24122: 24050: 23939: 23854: 23728: 23633: 23628: 23594: 23545: 23468: 23430: 23324: 23319: 23188: 23157: 23098: 22952: 21912: 21430:

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Only clinically utilised antipsychotic that does not act by antagonising the

2962: 2506: 2131: 2121: 1887: 1644: 1333:

may abate during withdrawal from the antipsychotic agent, or it may persist.

1235: 1118: 1067: 1061: 753: 629: 345: 201: 189: 87: 22625: 22179: 20969: 17076: 14546:"Evidence Lacking to Support Many Off-label Uses of Atypical Antipsychotics" 13975: 13859: 12530: 11795:"What's in a name? The evolution of the nomenclature of antipsychotic drugs" 11048:) also exist, which must be held under the tongue for absorption. The first 27435: 27271: 26758: 26753: 26738: 26658: 26618: 26592: 26587: 26546: 26541: 26390: 26335: 26325: 26290: 26280: 26209: 26169: 26129: 26089: 26064: 26054: 26044: 25994: 25969: 25964: 25934: 25889: 25693: 25688: 25648: 25501: 25331: 25311: 25301: 25245: 25230: 25220: 25135: 24680: 24599: 24335: 24293: 24127: 24117: 24033: 24028: 23691: 23616: 23599: 23564: 23491: 23486: 23362: 23352: 23334: 23265: 23250: 23228: 23203: 23193: 23170: 23022:– information from mental health charity The Royal College of Psychiatrists 22970: 22907: 22872: 22863: 22846: 22797: 22703: 22660: 22643: 22600: 22480: 22273: 22198: 22106: 21997:

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17139: 17094: 17037: 17028: 17011: 16996: 16955: 16906: 16857: 16808: 16722: 16673: 16624: 16581: 16542: 16443: 16396: 16339: 16298: 16247: 16198: 16163: 16128: 16071: 16036: 15993: 15949: 15903: 15868: 15819: 15736: 15687: 15644: 15609: 15563: 15420: 15377: 15334: 15265: 15222: 15187: 15122: 15073: 15037: 14980: 14945: 14904: 14863: 14814: 14765: 14721: 14678: 14523: 14515: 14488: 14439: 14404: 14369:

Hardoon S, Hayes J, Viding E, McCrory E, Walters K, Osborn D (March 2022).

14279: 14220: 14179: 14122: 14087: 14061: 14007: 13960: 13901: 13844: 13750: 13699: 13665: 13616: 13530: 13475: 13448: 13413: 13382: 13346: 13287: 13251: 13200: 13126: 13060: 12996: 12987: 12970: 12941: 12881: 12846: 12809: 12794: 12734: 12691: 12638: 12597: 12579: 12548: 12499: 12455: 12380: 12339: 12298: 12254: 12205: 12106: 12071: 12014: 11908: 11864: 11820: 11764: 11704: 11669: 11617: 11599: 11539: 11501: 11441: 11403: 11354: 11285: 11190: 11087: 10979: 10967:, even though – strictly speaking – the two terms are not interchangeable. 10834: 10266: 9686: 9601: 9397: 9280: 8941: 8854: 8633: 5648: 5602: 5119: 4928: 4436: 4399: 4346: 4059: 3658: 3346: 3322: 3178: 3058: 2866: 2842: 2674: 2650: 2578: 2386: 2261: 2105: 2083: 2017: 1912: 1853: 1717: 1712: 1655: 1612: 1601: 1596: 1571: 1551: 1541: 1519: 1489: 1261: 1198: 1032:(particularly common with first-generation antipsychotics), which include: 777: 738: 722: 577: 399: 330: 232: 227:

The use of antipsychotics may result in many unwanted side effects such as

216: 22298:"Abuse of second-generation antipsychotics: What prescribers need to know" 21693: 21658: 21623: 21528: 21483: 21382: 21217: 19942: 19293: 18847: 18050: 17934: 16848: 16831: 16664: 16647: 15850: 15257: 13327: 12629: 12612: 12153: 11301: 27215: 27108: 26943: 26723: 26708: 26693: 26556: 26526: 26521: 26516: 26486: 26460: 26455: 26450: 26425: 26420: 26405: 26395: 26375: 26370: 26355: 26345: 26340: 26330: 26310: 26295: 26275: 26260: 26214: 26149: 26124: 26114: 26109: 26104: 26059: 26034: 26004: 25954: 25914: 25859: 25854: 25834: 25799: 25784: 25774: 25764: 25744: 25734: 25678: 25593: 25516: 25511: 25496: 25449: 25356: 25351: 25341: 25306: 25281: 25250: 25210: 25090: 25035: 25009: 24999: 24938: 24564: 24474: 24214: 24167: 24112: 23995: 23961: 23738: 23686: 23638: 23611: 23586: 23581: 23576: 23554: 23511: 23496: 23460: 23440: 23435: 23425: 23374: 23292: 23260: 23218: 23208: 23175: 23142: 23125: 23108: 22898: 21768: 21580: 21545:

Curry SH, Whelpton R, de Schepper PJ, Vranckx S, Schiff AA (April 1979).

21500:

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19565:(2013 ed.). Adelaide: The Australian Medicines Handbook Unit Trust. 18145:. Handbook of Experimental Pharmacology. Vol. 212. pp. 87–124. 17994:

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15679: 15522:

Specifications Manual for Joint Commission National Quality Core Measures

15489:. Vol. 1 (Second ed.). American Psychiatric Association. 2006. 15113: 14270: 13914: 13374: 11613: 11394: 11377: 11150: 11118: 10802: 10607: 10594: 9801: 9567: 9360: 9323: 9017: 8978: 8904: 8891: 8797: 8727: 8594: 5938: 5743: 5420: 5411:

Removed from the market amidst concerns about an alarmingly high rate of

5379: 5223: 5082: 5045: 4559: 4490: 4354: 4205: 3950: 3940: 3916: 3802: 3778: 3538: 3514: 3418: 3394: 3298: 3274: 3226: 3130: 3106: 2914: 2890: 2818: 2770: 2698: 2554: 2530: 2482: 2362: 2253: 2193: 2170: 2149: 2035: 2011: 1883: 1879: 1865: 1859: 1839: 1835: 1800: 1794: 1772: 1737: 1722: 1700: 1665: 1660: 1576: 1566: 1531: 1495: 1467: 1451: 1441: 1337: 1268: 1203: 969: 946: 923: 915: 865: 857: 828: 820: 773: 726: 710: 581: 282: 240: 23045: 22254: 20748: 20475: 18064:

Tiwari P, Panik R, Bhattacharya A, Ahirwar D, Chandy A (December 2012).

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Shen WW (December 1999). "A history of antipsychotic drug development".

11612:

please see Chopra et al 2021: Strengths and limitations "only examined

11420:

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2224:

receptors in cortical and subcortical areas, in particular in the right

27286: 27276: 27096: 26728: 26718: 26713: 26698: 26653: 26648: 26577: 26506: 26501: 26491: 26445: 26440: 26430: 26415: 26410: 26380: 26350: 26320: 26300: 26219: 26189: 26029: 26024: 26019: 26014: 26009: 25989: 25959: 25949: 25909: 25904: 25899: 25894: 25879: 25864: 25819: 25814: 25809: 25804: 25769: 25759: 25754: 25739: 25663: 25627: 25588: 25567: 25521: 25475: 25439: 25387: 25336: 25321: 25286: 25195: 25125: 25120: 25105: 25100: 25053: 25030: 25004: 24989: 24943: 24917: 24912: 24907: 24902: 24897: 24892: 24742: 24713: 24671: 24640: 24635: 24574: 24569: 24559: 24497: 24483: 24423: 24378: 24326: 24246: 24242: 24183: 24143: 24098: 24094: 23984: 23920: 23870: 23835: 23831: 23718: 23696: 23671: 23661: 23559: 23501: 23450: 23223: 23152: 23120: 23103: 22223:

Atypical antipsychotics: overrated and overprescribed, Glen Spielsman,

21805: 21745:

Studies in History and Philosophy of Biological and Biomedical Sciences

21374: 21209: 20835: 20246:

Fenton M, Rathbone J, Reilly J, Sultana A (July 2007). Reilly J (ed.).

19723: 18310: 17693: 13827: 13810: 13630:

Lühnen J, Richter T, Calo S, Meyer G, Köpke S, Möhler R (August 2023).

12245: 12228: 11466:

Ho BC, Andreasen NC, Ziebell S, Pierson R, Magnotta V (February 2011).

11083: 11079: 10904: 10821: 10813: 10790: 10570: 10496: 10459: 10316: 10242: 10205: 10094: 9608: 9516: 9241: 9147: 8861: 5920: 5487: 5301: 5293: 4863: 4711: 4362: 4350: 3634: 3562: 3490: 3154: 3010: 2794: 2722: 2458: 2118:(Abilify Maintena) – Long-acting version of aripiprazole for injection. 2031: 1971: 1961: 1945: 1893: 1847: 1822: 1780: 1727: 1695: 1536: 1477: 1446: 1436: 1341: 1295:

along with worsening of symptoms has been described in the literature.

861: 824: 657: 593: 589: 585: 411: 55: 41: 21685: 21671: 20625: 20536: 17916: 17252: 15718: 15326: 15243: 14618:"Antipsychotics are increasingly prescribed to children and teenagers" 14114: 13232: 12437: 12098: 2247:

receptors in these other pathways is thought to produce some unwanted

341:

Antipsychotics are most frequently used for the following conditions:

157: 27420: 27261: 27225: 27120: 27079: 27074: 26996: 26958: 26788: 26768: 26733: 26678: 26673: 26628: 26582: 26572: 26365: 26360: 26305: 26265: 26184: 26174: 26164: 26154: 26069: 25944: 25884: 25874: 25849: 25839: 25829: 25789: 25729: 25724: 25643: 25598: 25541: 25536: 25470: 25465: 25460: 25444: 25402: 25397: 25291: 25276: 25175: 25140: 25040: 24968: 24963: 24650: 24630: 24604: 24579: 24514: 24492: 24320: 24233: 24107: 23723: 23656: 23651: 23646: 23526: 23481: 23473: 23445: 23420: 23386: 23314: 23147: 21166: 21111: 14805: 14788: 12971:"Community treatment orders and antipsychotic long-acting injections" 11170: 11045: 10842: 10725: 9725: 9647: 9186: 9139: 8812: 8680: 5656: 5552: 4826: 4784: 4296: 4140: 4089: 4022: 3706: 3610: 3586: 3466: 3082: 3034: 2746: 2434: 2274:

receptors; however, most also act on serotonin receptors, especially

2112:

receptor. Considered the prototypical third-generation antipsychotic.

1931: 1925: 1906: 1843: 1784: 1749: 1690: 1586: 1280: 1085: 1035: 832: 278: 260: 236: 181: 119: 22986:

Recommendations for the use of antipsychotics for treating psychosis

21608: 20338:

Marques LO, Lima MS, Soares BG (2004). de Oliveira Marques L (ed.).

19984:. The Royal Pharmaceutical Society of Great Britain. 30 January 2013 17511: 16557: 16556:

Koller EA, Cross JT, Doraiswamy PM, Malozowski SN (September 2003).

16372: 15517:"HBIPS-4, Patients discharged on multiple antipsychotic medications" 12135: 11327: 11325: 11323: 11321: 11319: 11317: 11315: 11313: 11311: 741:. Many people receive these medication for over a year, contrary to 27113: 27059: 26778: 26613: 26531: 26465: 26144: 26119: 26094: 26084: 25794: 25779: 25709: 25619: 25557: 25552: 25526: 25377: 25361: 25225: 25066: 24958: 24922: 24887: 24751: 24615: 24611: 24584: 24023: 23956: 23875: 23676: 23506: 23455: 23255: 23180: 23137: 21130: 21055: 20851: 20679:

Arafat SM, Rahman SM, Haque MM, Shah MA, Algin S, Nahar JS (2016).

19205: 19095:

Before Prozac: The Troubled History of Mood Disorders in Psychiatry

17204:

Tampi RR, Tampi DJ, Balachandran S, Srinivasan S (September 2016).

15970: 15487:

Practice Guideline for the Treatment of Patients With Schizophrenia

15311: 15004:"Clozapine versus typical neuroleptic medication for schizophrenia" 13712: 11165:

antipsychotic drugs prescribed for children with bipolar disorder.

11154: 11114: 10908: 10900: 10846: 10794: 10773: 10744: 10678: 10644: 10533: 10168: 10131: 9844: 9436: 9097: 5808: 5169: 5077:

Also used to treat severe anxiety. Not licensed for use in the US.

4995: 4661: 3906: 3826: 3682: 3370: 3250: 2986: 2178: 1994: 1732: 1561: 1501: 1457: 1292: 1257: 1217:, particularly in people treated with chlorpromazine and clozapine. 1214: 1041: 804: 718: 641: 637: 388: 384: 221: 193: 185: 95: 18591: 18490:

Neurotransmitter Receptors in Actions of Antipsychotic Medications

16358:"Antipsychotic Use Associated With Elevated Risk of Breast Cancer" 13811:"Antipsychotics in the maintenance phase for psychotic depression" 12761:"Maintenance treatment with antipsychotic drugs for schizophrenia" 12226: 11563: 463: 27051: 26643: 26481: 26270: 26099: 25869: 25719: 25714: 25683: 25085: 24984: 24979: 24727: 24645: 24310: 24077: 23899: 23849: 23270: 22211:

Risky Antipsychotic Drugs Still Overprescribed In Nursing Homes,

22073:

Pipelineantipsychotic drugs to drive next market evolution (2009)

21867:

A guide to the extrapyramidal side-effects of antipsychotic drugs

18281: 16968: 13561:. AMDA – The Society for Post-Acute and Long-Term Care Medicine. 12611:

Leucht S, Arbter D, Engel RR, Kissling W, Davis JM (April 2009).

11682: 11308: 11134: 10960: 10740: 9533:@ 250 mg q8hr 778 ng/mL (male), 879 ng/mL (female) 9210:(25 mg, orally), 2228–3416 ng/mL (50 mg, orally), 5853:

Dose-dependent risk of seizures. Not licensed for use in the US.

4013:

common on overdose. Has a comparatively low penetrability of the

2059: 2038:. Like the other atypical antipsychotics, it is believed to have 1365: 942: 796: 781: 73: 26877: 22610:"Nonpharmacologic management of behavioral symptoms in dementia" 22551: 22512: 22391:"Justice suit accuses Johnson & Johnson of paying kickbacks" 21504:(30th ed.). London: Pharmaceutical Press. pp. 364–623. 20507: 19763:. Royal Pharmaceutical Society of Great Britain. 30 January 2013 19654: 19652: 19650: 19360:

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Orejarena MJ, Lanfumey L, Maldonado R, Robledo P (August 2011).

17947: 17203: 16473:

Goodman & Gilman's The Pharmacological Basis of Therapeutics

15446: 13857: 12715:

Progress in Neuro-Psychopharmacology & Biological Psychiatry

8992:

2–6 h (Oral), 10–20 min (short-acting IM), 6–7 days (depot)

2099: 2051:

Third generation antipsychotics are recognized as demonstrating

26783: 25749: 25603: 25480: 25045: 24409: 24072: 22823: 21544: 20954: 20394:. Royal Pharmaceutical Society of Great Britain. 16 August 2013 18767: 18765: 16555: 13766: 12353:

Keefe RS, Silva SG, Perkins DO, Lieberman JA (1 January 1999).

12270: 11937:(11th ed.). Chichester, West Sussex, UK: Wiley-Blackwell. 11331: 11146: 11142: 11138: 9916: 9877: 9873: 9834: 9830: 9754: 9715: 9637: 9596: 9545: 9469: 9465: 9426: 9313: 9309: 9270: 9176: 9134: 9130: 9126: 9050: 9046: 9007: 8849: 8845: 8841: 8802: 8756: 8735:

10.7–16.2 h (single dosing), 67.9 h (repeated dosing)

8717: 8713: 8709: 8670: 8666: 2213: 2205: 1340:

rebound, an activation syndrome, and motor syndromes including

1230: 1158: 1130:

antipsychotic drugs) adverse effects of antipsychotics include:

1006:

antipsychotic drugs) adverse effects of antipsychotics include:

702: 487: 22339:"GPs under 'pressure' to issue neuroleptics, claims professor" 21360: 21273: 21078: 20647: 19704: 18565:

Methods and Findings in Experimental and Clinical Pharmacology

18063: 13976:"Off-label use of atypical antipsychotics: cause for concern?" 13681: 13503:

Ventimiglia J, Kalali AH, Vahia IV, Jeste DV (November 2010).

12758: 4817:

atypical antipsychotic that has been tried as a treatment for

2014:– Approved by the PMDA in 2008. Used in Japan and South Korea. 1373: 1193:, reduced iron plasma levels, electrolyte abnormalities, etc.) 819:

offer advantages over older, first generation antipsychotics.

26963: 26603: 25704: 24709: 24419: 23914: 22238:"Transdermal Asenapine in Schizophrenia: A Systematic Review" 22068: 22066: 21238: 21060: 20558: 20294: 19647: 18230: 17752: 16645: 15784:

De Berardis D, Rapini G, Olivieri L, et al. (May 2018).

15001: 14143: 13545:

AMDA – The Society for Post-Acute and Long-Term Care Medicine

13461: 13434: 12668: 11153:

faces numerous personal-injury lawsuits from former users of

10874: 10870: 10422: 10350: 10279: 10057: 10020: 2299:

Through the ability of most antipsychotics to antagonize 5-HT

1953: 1783:

effects in non-schizophrenic patients, leading to its use in

1381: 1253: 981: 900:

For more detailed comparison of atypical antipsychotics, see

561:

Antipsychotics are routinely used, often in conjunction with

483: 314: 302: 23002:

Are atypical antipsychotics advantageous? – the case against

22879: 21594:

Young D, Ereshefsky L, Saklad SR, Jann MW, Garcia N (1984).

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6 h (Oral), 15–45 min (short-acting IM), 7 days (depot)

2086:(Caplyta) – In December 2019, lumateperone, a presynaptic D 1609:(only English-speaking country it is available in is Canada) 1183:

Mental status change (confusion, hallucinations, coma, etc.)

24413: 20732:"Clozapine As Transformative Treatment In Bipolar Patients" 20245: 19707:"Profile of blonanserin for the treatment of schizophrenia" 19610: 19446: 17512:

Sacchetti E, Vita A, Siracusano A, Fleischhacker W (2013).

15094: 14501: 13502: 13178: 12859: 12831:(8). American Psychiatric Association Publishing: 765–773. 12512: 12484:(4). American Psychiatric Association Publishing: 343–350. 10841:

company, first used the term tranquilizer to differentiate

9142:(a tricyclic antidepressant), 7-OH loxapine, 8-OH loxapine 6386:

toward cloned human receptors (unless otherwise specified)

2304: 989:

imbalance and immune-mediated hypersensitivity reactions).

22844: 22063: 21794:(4th ed.). Britain: Elsevier Limited. pp. 8, 17. 20918: 19879: 19500: 18645: 17152: 15927: 15246:

The International Journal of Risk & Safety in Medicine

13808: 13774:"FDA Psychopharmacologic Drugs Advisory Committee Hearing" 12712: 12420:

McGorry PD, Hartmann JA, Spooner R, Nelson B (June 2018).

12352: 11885: 9524:

6 h (IR), 7 h (XR); active metabolite: 12 h

8744:

0.14–0.76 ng/mL (0.57 ng/mL for repeated dosing)

4656:

Also used as an analgesic, agitation, anxiety and emesis.

2042:

activity at dopamine and serotonin receptors in the brain.

50: 25531: 22160: 21894: 21593: 21514: 20958:

The Journal of Pharmacology and Experimental Therapeutics

20601: 19585: 19533: 19527: 19506: 19479: 19473: 19452: 19416: 19187: 18771: 18741: 17442:

Adverse Syndromes and Psychiatric Drugs: A Clinical Guide

17401: 17303: 16920:

Vita A, De Peri L, Deste G, Sacchetti E (November 2012).

16919: 16497:

Weston-Green K, Huang XF, Deng C (2012). Chang AY (ed.).

15783: 14577:"Prescribing antipsychotics for children and adolescents" 14368: 12610: 12471: 11465: 10996: 10975:

drugs, because the latter have a wider range of effects.

9958:

Pharmacokinetics of long-acting injectable antipsychotics

6041:++ (prevents manic and mixed but not depressive episodes) 1890:

or those taking other drugs that prolong the QT interval.

22996:

Are atypical antipsychotics advantageous? – the case for

21195: 19923: 19398: 19169: 19052: 18989:

Bioactive Heterocyclic Compound Classes: Pharmaceuticals

18721:. Springer Science & Business Media. pp. 360–. 18675: 18627: 18028: 17438: 17402:

Joint Formulary Committee B, ed. (March 2009). "4.2.1".

16049: 15701:

Carbon M, Kane JM, Leucht S, Correll CU (October 2018).

15442: 15440: 15438: 15050: 14742: 14650: 13809:

Al-Wandi A, Landén M, Nordenskjöld A (6 November 2023).

13264: 12818: 10926:

Antipsychotics are broadly divided into two groups, the

10923:

for insomnia. They are potentially addictive sedatives.

4200:

Oral hypoesthesia. Has a complex pharmacologic profile.

1011:

Dysphoria and apathy (due to dopamine receptor blockade)

22726: 22668:

Richter T, Meyer G, Möhler R, Köpke S (December 2012).

22667: 21973:

Lexicon of Psychiatry, Neurology, and the Neurosciences

19139: 17867: 16752:"Understanding and treating depersonalisation disorder" 16749: 16469: 16352: 15700: 15143: 14699: 13037: 11842: 11419: 1886:

in the heart, which can be dangerous for patients with

21706: 19784:"Fluphenazine (oral) versus placebo for schizophrenia" 19359: 18609: 16212:

Praharaj SK, Jana AK, Goyal N, Sinha VK (March 2011).

16211: 15881: 14958: 14786: 14301:

Work Group on Borderline Personality Disorder (2001).

13629: 12154:"American Psychiatric Association Practice Guidelines" 11932: 9204:

1.6–2.4 h (Oral, tablets), 1 h (Oral, syrup)

9191:

54% (Oral via syrup), 65% (Oral via tablets), 87% (IM)

926:(typical). A rare but potentially lethal condition of 394:

Antipsychotics are used to treat tics associated with

23819:

Anatomical Therapeutic Chemical Classification System

22518:"Five Things Physicians and Patients Should Question" 22372:"UK study warns against anti-psychotics for dementia" 22161:

Gustafsson M, Karlsson S, Lövheim H (February 2013).

21999:, Cengage Learning, Boston, pp. 150-186 and 342-349, 21439: 20681:"Clozapine Can Be the Good Option in Resistant Mania" 20678: 17518:. Springer Science & Business Media. p. 85. 16786: 16648:"Schizophrenia, neuroleptic medication and mortality" 16496: 16417: 15452:"Five Things Physicians and Patients Should Question" 15435: 13781:

American Academy of Child & Adolescent Psychiatry

13585:

Ballard C, Waite J (January 2006). Ballard CG (ed.).

13395: 11378:"Antipsychotic medication in schizophrenia: a review" 671:

concluded that the use of those drugs in addition to

22732:"Ten Things Physicians and Patients Should Question" 22508: 22506: 22504: 22235: 21700: 21587: 21433: 20872: 20605:

The International Journal of Neuropsychopharmacology

20514:

The International Journal of Neuropsychopharmacology

20297:

Documenta Ophthalmologica. Advances in Ophthalmology

20120: 20048:

Onrust SV, McClellan K (April 2001). "Perospirone".

18859: 18857: 18288:

The International Journal of Neuropsychopharmacology

17058: 16602: 13549:"Ten Things Physicians and Patients Should Question" 12948: 12568:

The International Journal of Neuropsychopharmacology

9227:

Urine (70% as metabolites, 5.5–10.4% as parent drug)

2077: 1522:— although it is mostly used in veterinary medicine. 1357:

100,000 patients are probably in the same position.

709:

or personality disorder. The atypical antipsychotic

22650: 22607: 20002: 19781: 19314: 18979: 18936: 16014: 14917: 14080:

Off-Label Use of Atypical Antipsychotics: An Update

14077: 12472:Starzer MS, Nordentoft M, Hjorthøj C (April 2018). 4394:Mostly used for postoperative nausea and vomiting. 1409:# denotes drugs that have been withdrawn worldwide. 1100:

Dry mouth (although hypersalivation may also occur)

1038:, an often distressing sense of inner restlessness. 432:Antipsychotic drug treatment is a key component of 22934: 22608:Gitlin LN, Kales HC, Lyketsos CG (November 2012). 22442:"Drug Maker's E-Mail Released in Seroquel Lawsuit" 21975:. Lippincott Williams & Wilkins. p. 675. 19016:Pedersen V (1996). "Thioxanthene antipsychotics". 18710: 18708: 17989: 17987: 16470:Brunton LL, Chabner B, Knollmann BC, eds. (2011). 16418:Weston-Green K, Huang XF, Deng C (February 2010). 16052:Expert Opinion on Drug Metabolism & Toxicology 15581: 15200: 14876: 13921:Australian & New Zealand Journal of Psychiatry 12819:Tiihonen J, Tanskanen A, Taipale H (August 2018). 11259:. Lippincott Williams & Wilkins. p. 151. 11252: 11141:. In the Bextra case, the government also charged 10769:Timeline of the development of antipsychotic drugs 9882:Norzotepine (a norepinephrine reuptake inhibitor) 2292:antagonism increases dopaminergic activity in the 2024:receptor antagonist approved for the treatment of 1829: 1174:, a potentially fatal condition characterized by: 22501: 22493:: CS1 maint: DOI inactive as of September 2024 ( 21131:"electronic Medicines Compendium (eMC) home page" 20914: 20912: 20337: 19590:(65 ed.). London, UK: Pharmaceutical Press. 19240: 19238: 18854: 18558: 18556: 18554: 18552: 18550: 18548: 18546: 18544: 18542: 18540: 18538: 18536: 18534: 18532: 18530: 18448: 17538: 17352: 16205: 15622: 12968: 11935:The Maudsley prescribing guidelines in psychiatry 11629:please see Chopra et al 2021: Method Study design 10955:was used for older antipsychotic drugs. The term 3882:Tolerability (as propensity for adverse effects) 2034:– Developed by the Danish pharmaceutical company 1991:by means of its active metabolite, norquetiapine. 613:National Institute for Health and Care Excellence 604:as a maintenance treatment for bipolar disorder. 379:as an adjunct to standard antidepressant therapy. 27448: 24852: 23008:First Generation Antipsychotics: An Introduction 22229: 22023:. Jones & Bartlett Publishers. p. 317. 21495: 21493: 20998: 19213:"Paliperidone palmitate – Johnson & Johnson" 19011: 19009: 18528: 18526: 18524: 18522: 18520: 18518: 18516: 18514: 18512: 18510: 18427:Farmacología y endocrinología del comportamiento 18419: 18417: 18415: 18413: 18411: 18409: 18407: 18405: 18403: 18401: 18399: 18397: 18395: 18393: 18391: 18389: 18387: 18385: 18383: 18381: 18379: 18377: 18375: 18373: 18371: 18369: 18367: 18365: 18363: 18361: 18359: 18357: 18355: 18353: 18351: 18349: 17655:"Up to 100,000 on antipsychotics with no review" 17439:Haddad P, Haddad PM, Dursun S, Deakin B (2004). 16829: 16370: 16305: 15511: 14417: 14073: 14071: 13973: 12969:Lambert TJ, Singh BS, Patel MX (November 2009). 12905: 11145:with illegally marketing another antipsychotic, 10885:, meaning "take hold of"). Thus, the word means 9114:257 ng/mL (inhaled), 6–13 ng/mL (Oral) 5898:based on the pharmacologic profile of the drug. 1248:List of long term side effects of antipsychotics 438:National Institute of Health and Care Excellence 22291: 22289: 22287: 22285: 22283: 21457: 21455: 21151: 20729: 20047: 19924:Röhricht F, Gadhia S, Alam R, Willis M (2012). 19087: 19085: 18735: 18705: 18454: 18347: 18345: 18343: 18341: 18339: 18337: 18335: 18333: 18331: 18329: 18103: 18101: 17984: 17709: 17395: 16092: 15779: 15777: 14192: 13677: 13675: 13498: 13496: 13494: 13492: 13216:"Quetiapine monotherapy for bipolar depression" 13015:Applied therapeutics: the clinical use of drugs 12981:(S52). Royal College of Psychiatrists: S57-62. 12136:"Psychosis and schizophrenia in adults (CG178)" 9111:2 min (inhaled), 2 h (oral), 5 h (IM) 8986:10–20 h (short-acting IM), 3 weeks (depot) 8881:2 L/kg (adults), 0.58 L/kg (children) 5817: 5785: 5752: 5702: 5611: 5561: 5529: 5496: 5464: 5429: 5343: 5310: 5178: 5128: 5004: 4972: 4937: 4905: 4872: 4753: 4720: 4670: 4601: 4568: 4532: 4499: 4445: 4305: 4251: 4182: 4149: 4107: 4068: 3992: 3959: 1755: 787:Aggressive challenging behavior in adults with 505: 464:Prevention of psychosis and symptom improvement 22935:Fallon P, Dursun S, Deakin B (February 2012). 22578: 22084: 21738: 21540: 21538: 21461: 21317: 21115:. United States National Library of Medicine. 20909: 20003:Leucht S, Helfer B, Hartung B (January 2014). 19315:Leucht S, Helfer B, Hartung B (January 2014). 19235: 19098:. Oxford University Press, USA. pp. 14–. 18985: 18562: 17993: 17710:Onrust SV, McClellan K (2001). 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New York: McGraw-Hill. 16218:British Journal of Clinical Pharmacology 16008: 15616: 14014: 13008: 13006: 11915: 11799:Journal of Psychiatry & Neuroscience 11559: 11557: 11508: 11074:for their sedative, tranquilizing, and ( 10772: 10764: 9105:6–8 h (Inhaled), 4–12 h (Oral) 8619:Faeces (20%), urine (50%, when given IV) 6155:+++ (only in the treatment of agitation) 5965:+++ high propensity/severity for this AE 1380: 1372: 1364: 810: 27022:Depression in childhood and adolescence 26473:Antiemetics/gastroprokinetics/sedatives 22562:10.1176/appi.books.9780890423967.152139 22355: 20456: 20392:Martindale: The Complete Drug Reference 20100:Martindale: The Complete Drug Reference 19981:Martindale: The Complete Drug Reference 19761:Martindale: The Complete Drug Reference 19424:"Pimavanserin – ACADIA Pharmaceuticals" 19271: 19091: 18986:Lamberth C, Dinges J (16 August 2012). 18869:. Gale Research. 1991. p. 52,169. 18798: 18423: 18140: 17907:. 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Successor of aripiprazole. 2124:(Rexulti) – Partial agonist of the D 2108:(Abilify) - Partial agonist at the D 1241: 1126:Rare/Uncommon (<1% incidence for 27065:Depression (differential diagnoses) 26075:Levomepromazine (methotrimeprazine) 24056:Angiotensin II receptor antagonists 23246:Levomepromazine (methotrimeprazine) 22886:The New England Journal of Medicine 22461:Ethical Human Sciences and Services 22417:"Side Effects May Include Lawsuits" 21966: 21960: 21884:from the original on 18 March 2016. 21502:Martindale: The Extra Pharmacopoeia 21099: 21095:from the original on 21 April 2013. 20340:"Trifluoperazine for schizophrenia" 19968: 18693:from the original on 18 August 2017 18430:. 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Both generations of medication 25: 27483: 27389:Transcranial magnetic stimulation 27154:Bipolar Spectrum Diagnostic Scale 26907: 22979: 22832:from the original on 27 June 2013 22556:. Vol. 1 (Second ed.). 22389:Hilzenrath DS (16 January 2010). 22167:BMC Pharmacology & Toxicology 22049:. OUP Oxford. 2010. p. 329. 19412:. Springer Nature Switzerland AG. 19201:. Springer Nature Switzerland AG. 19183:. Springer Nature Switzerland AG. 18715:Csernansky JG (6 December 2012). 18653:"Brexpiprazole – Lundbeck/Otsuka" 18641:. Springer Nature Switzerland AG. 18623:. Springer Nature Switzerland AG. 18605:. Springer Nature Switzerland AG. 17636:BMJ Group (March 2009). 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weeks 10025:441–1064 mg/4–8 weeks 9040:Urine (45–58%), faeces (20–22%) 5214:High potency first-generation ( 4481:High-potency first-generation ( 2078:Benzisoxazoles/benzisothiazoles 1919: 1830:Benzisoxazoles/benzisothiazoles 1766: 731:borderline personality disorder 428:Schizophrenia § Medication 336: 22686:10.1002/14651858.cd008634.pub2 22356:Triggle N (12 November 2009). 20658:10.1002/14651858.CD008121.pub2 20356:10.1002/14651858.CD003545.pub2 20264:10.1002/14651858.CD001944.pub2 20215:10.1002/14651858.CD007811.pub2 20180:10.1002/14651858.CD001949.pub3 20139:10.1002/14651858.CD003443.pub3 20017:10.1002/14651858.CD002832.pub3 19849:10.1002/14651858.CD001943.pub2 19800:10.1002/14651858.CD006352.pub3 19374:10.1002/14651858.CD007479.pub2 19329:10.1002/14651858.CD002832.pub3 19274:Acta Psychiatrica Scandinavica 18683:"Cariprazine – Gedeon Richter" 17471:Acta Psychiatrica Scandinavica 17371:10.1176/appi.ajp.2012.12030342 15020:10.1002/14651858.CD000059.pub2 14467:Canadian Journal of 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691:post-traumatic stress disorder 377:Treatment resistant depression 229:involuntary movement disorders 13: 1: 26838:Monoamine reuptake inhibitors 26811:Receptor/signaling modulators 24990:Adrogolide (ABT-431, DAS-431) 23945:Thrombolytics / fibrinolytics 22475:(inactive 2 September 2024). 22440:Wilson D (27 February 2009). 22017:Patel SC, Jakopac KA (2011). 21901:Journal of Psychopharmacology 20875:Journal of Psychopharmacology 20428:10.1016/S0140-6736(11)60873-8 20056:(4): 329–37, discussion 338. 19563:Australian Medicines Handbook 18458:Analogue-based Drug Discovery 18188:Journal of Psychopharmacology 18083:10.1016/s2305-0500(13)60105-0 18008:10.1016/S0193-953X(02)00030-8 17718:(4): 329–37, discussion 338. 17541:Journal of Psychopharmacology 16574:10.1592/phco.23.10.1123.32759 16064:10.1517/17425255.2015.1075003 15625:Journal of Psychopharmacology 15370:10.1016/S0920-9964(98)00160-1 15203:Current Opinion in Psychiatry 14961:Journal of Psychopharmacology 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27364:Dialectical behavior therapy 27359:Cognitive behavioral therapy 27179:Rating scales for depression 24656:Wakefulness-promoting agents 23004:, Australian Prescriber 2005 21841:10.1007/978-0-387-34708-0_13 21709:Current Therapeutic Research 21442:Current Therapeutic Research 20934:10.1016/j.ejphar.2007.06.058 20005:"Perazine for schizophrenia" 19895:10.1016/j.schres.2011.01.004 19833:"Loxapine for schizophrenia" 19625:10.1097/JCP.0b013e3181e5c14c 19540:. 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Long-term use can produce 7: 27174:Mood Disorder Questionnaire 27002:Seasonal affective disorder 22728:American Geriatrics Society 22415:Wilson D (2 October 2010). 22321:"Myth of the antipsychotic" 21792:Psychiatric Drugs Explained 21757:10.1016/j.shpsc.2011.05.003 19978:"Molindone Hydrochloride". 18834:Melich H (April 1971). "". 18577:10.1358/mf.2005.27.5.908643 18493:. 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CRC Press. p. 791. 15750:Moore DP, Puri BK (2012). 15066:10.1176/appi.ajp.163.2.185 14973:10.1177/026988110001400411 14746:Current Psychiatry Reports 14630:10.3310/nihrevidence_57289 14480:10.1177/070674371205700302 14348:10.3310/nihrevidence_54520 14199:Behavioural Brain Research 13214:Thase ME (February 2008). 11747:10.2174/138161210790361461 11582:10.1038/s41386-021-00980-0 11059: 10760: 10737:medium-chain triglycerides 10701: 9913:Oral, IM (including depot) 9593:Oral, IM (including depot) 9405:9–12 h (10–19 h) 9267:Oral, IM (including depot) 8967:Oral, IM (including depot) 8930:Oral, IM (including depot) 8524: 8499:HC – Human cortex receptor 8467: 6381: 6372: 5933:Extrapyramidal Side Effect 5894: 5255:Only available in the UK. 3881: 2751:Tricyclic/Dibenzodiazepine 2237:tuberoinfundibular pathway 1759: 1642: 1511: 1428: 1417: 1414:First-generation (typical) 1346:British National Formulary 1325:supersensitivity psychosis 1312:British National Formulary 1302: 1245: 996: 899: 737:are prescribed them in UK 554: 425: 410:antidepressants in women. 333:effects and side effects. 315: 303: 27401: 27369:Electroconvulsive therapy 27346: 27295: 27246: 27201: 27192: 27144: 27050: 27030: 26992:Major depressive disorder 26982: 26924: 26915: 26801: 26699:Metitepine (methiothepin) 26125:Pericyazine (periciazine) 25923: 25549:Dihydrexidine derivatives 25428: 25415: 25388:Metitepine (methiothepin) 25184: 25154: 24976:Dihydrexidine derivatives 24876: 24863: 24780: 24736: 24708: 24664: 24473: 24408: 24371: 24319: 24232: 24176: 24136: 24093: 23977: 23913: 23825: 23747: 23705: 23535: 23412: 23088: 22990:World Health Organization 22473:10.1891/1523-150X.3.3.147 21946:. Saunders. p. 956. 21810:Oxford English Dictionary 21320:Clinical Pharmacokinetics 21241:Clinical Pharmacokinetics 20806:10.1007/s40263-013-0085-7 20617:10.1017/S1461145711000885 20527:10.1017/S1461145709990344 19930:TheScientificWorldJournal 18487:Lidow MS (22 June 2000). 18301:10.1017/S1461145710001215 18250:10.3389/fncel.2021.681539 17767:10.1017/S1092852900019842 17676:Seeman P (January 2004). 16889:10.1017/S2045796022000476 16280:10.1177/20451253241255476 16187:American Family Physician 15298:10.1192/apt.bp.107.003970 14924:American Family Physician 14920:"Schizophrenia: a review" 14758:10.1007/s11920-013-0355-6 14594:10.1192/apt.bp.108.005652 14212:10.1016/j.bbr.2020.113098 13934:10.1177/00048674231210209 13193:10.1016/j.jad.2013.01.022 12924:10.9758/cpn.2018.16.4.361 12007:10.1007/s40265-014-0254-0 11901:10.1016/j.jad.2012.07.038 11532:10.1017/S0033291709992297 11137:, and the other involved 10858: 10654: 10326: 9824:Faeces (66%), urine (20%) 9590:Urine (70%), faeces (14%) 9539:Urine (73%), faeces (20%) 9303:Urine (80%), faeces (11%) 9264:Urine (57%), faeces (30%) 9001:Urine (30%), faeces (15%) 8884:Urine (75%), faeces (22%) 8835:Urine (50%), faeces (30%) 8750:Urine (59%), faeces (30%) 8703:Urine (50%), faeces (40%) 8656:Faeces (55%), urine (25%) 8496:HB – Human brain receptor 6351: 6340: 6334: 6331: 6311: 6303: 6300: 6297: 6294: 6291: 6283: 6280: 6277: 6274: 6271: 6251: 6234: 6231: 6223: 6220: 6217: 6214: 6211: 6191: 6177: 6171: 6154: 6151: 6131: 6114: 6111: 6103: 6100: 6097: 6094: 6091: 6071: 6060: 6054: 6051: 6043: 6040: 6037: 6034: 6031: 6011: 5983: 5886: 5883: 5877: 5874: 5871: 5868: 5865: 5849: 5846: 5843: 5840: 5837: 5834: 5831: 5828: 5812: 5799: 5796: 5778: 5775: 5772: 5769: 5766: 5763: 5747: 5734: 5731: 5725: 5722: 5719: 5716: 5713: 5697: 5684: 5681: 5678: 5675: 5672: 5669: 5666: 5663: 5643: 5640: 5637: 5634: 5631: 5628: 5625: 5622: 5606: 5593: 5590: 5587: 5584: 5581: 5578: 5575: 5572: 5556: 5543: 5540: 5522: 5519: 5516: 5513: 5510: 5507: 5491: 5478: 5475: 5457: 5454: 5451: 5448: 5443: 5440: 5424: 5407: 5404: 5401: 5398: 5395: 5392: 5389: 5386: 5357: 5354: 5336: 5333: 5330: 5327: 5324: 5321: 5305: 5285: 5282: 5273: 5251: 5248: 5242: 5239: 5236: 5233: 5230: 5210: 5207: 5204: 5201: 5198: 5195: 5192: 5189: 5173: 5160: 5157: 5154: 5151: 5148: 5145: 5142: 5139: 5123: 5110: 5107: 5104: 5098: 5095: 5092: 5089: 5073: 5070: 5064: 5061: 5058: 5055: 5052: 4999: 4986: 4983: 4965: 4962: 4959: 4954: 4951: 4948: 4932: 4919: 4916: 4898: 4895: 4892: 4889: 4886: 4883: 4867: 4854: 4851: 4845: 4842: 4839: 4836: 4833: 4812: 4809: 4806: 4803: 4800: 4797: 4794: 4791: 4767: 4764: 4746: 4743: 4740: 4737: 4734: 4731: 4715: 4702: 4699: 4693: 4690: 4687: 4684: 4681: 4665: 4652: 4649: 4643: 4640: 4637: 4634: 4631: 4615: 4612: 4594: 4591: 4588: 4585: 4582: 4579: 4563: 4546: 4543: 4525: 4522: 4519: 4516: 4513: 4510: 4494: 4477: 4474: 4471: 4468: 4465: 4462: 4459: 4456: 4440: 4427: 4424: 4421: 4418: 4415: 4412: 4409: 4406: 4387: 4381: 4378: 4375: 4372: 4369: 4337: 4334: 4331: 4328: 4325: 4322: 4319: 4316: 4300: 4283: 4280: 4277: 4274: 4271: 4268: 4265: 4262: 4246: 4233: 4230: 4227: 4224: 4221: 4218: 4215: 4212: 4209: 4196: 4193: 4175: 4172: 4169: 4166: 4163: 4160: 4144: 4123: 4118: 4100: 4097: 4094: 4085: 4082: 4079: 4063: 4050: 4047: 4044: 4041: 4038: 4035: 4032: 4029: 4006: 4003: 3985: 3982: 3979: 3976: 3973: 3970: 3954: 2991:Tricyclic/Dibenzoxazepine 2805:Dridol/Droleptan/Inapsine 2329: 2323:Comparison of medications 1985:major depressive disorder 1981:major depressive disorder 1743: 1143:type II diabetes mellitus 654:major depressive disorder 648:Major depressive disorder 180:primarily used to manage 156: 151: 137: 132: 118: 113: 82: 72: 67: 48: 39: 34: 27462:Psychiatry controversies 27184:Young Mania Rating Scale 27159:Child Mania Rating Scale 27038:Schizoaffective disorder 27017:Major depressive episode 26301:Clotiapine (clothiapine) 26175:Spiperone (spiroperidol) 26140:Piflutixol (pifluthixol) 24361:Topoisomerase inhibitors 24045:renin–angiotensin system 24039:Calcium channel blockers 23402:Zuclopenthixol decanoate 23303:Pipotiazine undecylenate 23166:Diphenylbutylpiperidines 23020:Antipsychotic Medication 22953:10.1177/2045125311431105 22319:James A (2 March 2008). 21913:10.1177/0269881119855343 21155:Human Psychopharmacology 21018:10.3389/fpsyt.2013.00102 20887:10.1177/0269881107082944 18200:10.1177/0269881116654697 17553:10.1177/0269881117728428 17272:10.3389/fpsyt.2018.00622 17222:10.1177/2040622316658463 16926:Translational Psychiatry 15802:10.1177/2042098618756261 15637:10.1177/0269881117728428 15556:10.2174/0929867043456070 15162:10.1176/ps.2008.59.5.500 12198:10.1177/0269881110391123 12054:10.1177/1745506518762664 11650:Comprehensive Psychiatry 11382:British Medical Bulletin 11217: 11178:consumer advocacy groups 11011: 10985: 10971:drugs are a subgroup of 10733:fractionated coconut oil 10558:Pipotiazine undecylenate 10284:2–12 mg/1 week 10045:Aripiprazole monohydrate 9170:Urine (9%), faeces (80%) 8486:RC – Cloned rat receptor 5943:PE – Prolactin elevation 3831:Tricyclic/Dibenzothiepin 2703:Tricyclic/Dibenzothiepin 2152:(Vraylar, Reagila) – A D 2142:partial agonist and 5-HT 1803:– Has a risk of causing 1484:Diphenylbutylpiperidines 679: 351:Schizoaffective disorder 108:autism spectrum disorder 92:Schizoaffective disorder 27311:Atypical antipsychotics 27070:Emotional dysregulation 26257:Atypical antipsychotics 25640:Atypical antipsychotics 25573:N,N-Propyldihydrexidine 25273:Atypical antipsychotics 25162:Tetrahydroisoquinolines 23387:Tiotixene (thiothixene) 22739:: an initiative of the 22626:10.1001/jama.2012.36918 22525:: an initiative of the 22180:10.1186/2050-6511-14-10 21005:Frontiers in Psychiatry 20970:10.1124/jpet.110.167346 20309:10.1023/A:1015768114192 17814:10.1093/ajhp/60.23.2437 17259:Frontiers in Psychiatry 17016:Neuropsychopharmacology 16354:University of Hong Kong 15459:: an initiative of the 13556:: an initiative of the 11570:Neuropsychopharmacology 11212:Antipsychotic switching 11195:extrapyramidal symptoms 10707:intramuscular injection 10666:Zuclopentixol decanoate 9575:3–17 h (24 h) 9194:2.1–6.4 h (Oral), 9120:Urine (56–70%), faeces 8483:RB – Rat brain receptor 3759:Tricyclic/Phenothiazine 3735:Tricyclic/Phenothiazine 3663:Tricyclic/Phenothiazine 3471:Tricyclic/Phenothiazine 3447:Tricyclic/Phenothiazine 3423:Tricyclic/Phenothiazine 3375:Diphenylbutylpiperidine 3351:Dibenzylpiperidinylurea 3327:Tricyclic/Phenothiazine 3279:Tricyclic/Phenothiazine 3255:Tricyclic/Phenothiazine 3231:Diphenylbutylpiperidine 3213:Invega Sustenna/Xeplion 3111:Tricyclic/Dibenzazepine 3063:Tricyclic/Phenothiazine 2943:Tricyclic/Phenothiazine 2871:Diphenylbutylpiperidine 2847:Tricyclic/Phenothiazine 2775:Tricyclic/Phenothiazine 2655:Tricyclic/Dibenzazepine 2607:Tricyclic/Phenothiazine 2583:Tricyclic/Dibenzazepine 2354:Developer/Originator(s) 1813:extrapyramidal symptoms 1081:Orthostatic hypotension 920:extrapyramidal symptoms 789:intellectual disability 762:intellectual disability 634:atypical antipsychotics 473:First-episode psychosis 329:—refers to both common 327:"which takes the nerve" 275:atypical antipsychotics 178:psychotropic medication 27374:Involuntary commitment 27136:Reduced affect display 27012:Melancholic depression 25931:Typical antipsychotics 25192:Typical antipsychotics 24153:Hormonal contraception 24083:Bile acid sequestrants 23864:Proton-pump inhibitors 23827:gastrointestinal tract 23570:Paliperidone palmitate 23517:Oxyprothepin decanoate 23397:Zuclopenthixol acetate 23368:Clopenthixol decanoate 23281:Perphenazine enanthate 23276:Perphenazine decanoate 23239:Fluphenazine enanthate 23234:Fluphenazine decanoate 22864:10.1001/jama.2011.1360 21612:Arzneimittel-Forschung 21289:10.1124/dmd.107.018275 19883:Schizophrenia Research 19561:Rossi, S, ed. 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Psychiatry 12988:10.1192/bjp.195.52.s57 12519:Schizophrenia Bulletin 12359:Schizophrenia Bulletin 11520:Psychological Medicine 10869:, originally meaning " 10782: 10770: 10739:). = Predicted, from 10484:Perphenazine enanthate 10447:Perphenazine decanoate 10410:Paliperidone palmitate 10375:Oxyprothepin decanoate 10230:Fluphenazine enanthate 10193:Fluphenazine decanoate 8869:2 h (8–12 h) 8761:N-desethylblonanserin 3855:Tricyclic/Thioxanthene 3711:Tricyclic/Thioxanthene 3363:ACADIA Pharmaceuticals 3203:Paliperidone palmitate 2823:Tricyclic/Thioxanthene 2679:Tricyclic/Thioxanthene 2631:Tricyclic/Thioxanthene 2571:Gedeon Richter/Actavis 2268:Atypical antipsychotic 1762:Atypical antipsychotic 1386: 1378: 1370: 1166:central nervous system 870:extrapyramidal effects 735:serious mental illness 545:long-acting injectable 534:involuntary commitment 495:drug induced psychosis 404:atypical antipsychotic 289:, but atypicals block 271:typical antipsychotics 208:, in the treatment of 168:, previously known as 26969:Mixed affective state 26865:Monoamine neurotoxins 25659:Aripiprazole lauroxil 23622:Aripiprazole lauroxil 23380:Flupentixol decanoate 23298:Pipotiazine palmitate 23131:Haloperidol decanoate 23114:Bromperidol decanoate 22125:16 April 2010 at the 21107:"Daily Med home page" 17761:(11 Suppl 17): 1–20. 17077:10.1093/schbul/sbn019 16849:10.1192/bjp.187.3.243 16665:10.1192/bjp.188.2.122 16312:Lieberman JA (2004). 16273:: 20451253241255476. 15851:10.2217/pgs-2018-0188 15258:10.3233/JRS-2012-0567 14883:BMJ Clinical Evidence 13885:1959.4/unsworks_79133 13328:10.1186/1471-244X-9-4 12958:. p. 10.11.1.27. 12630:10.1038/sj.mp.4002136 12531:10.1093/schbul/sbv125 11167:Johnson & Johnson 11131:Eli Lilly and Company 11109:for allegedly paying 11107:Johnson & Johnson 11022:outpatient commitment 10776: 10768: 10632:Zuclopentixol acetate 10521:Pipotiazine palmitate 10304:Haloperidol decanoate 10156:Flupentixol decanoate 10119:Clopentixol decanoate 10082:Bromperidol decanoate 10008:Aripiprazole lauroxil 9806:60% (Oral), 100% (IM) 9214:(100 mg, orally) 8641:75 h (94 h) 8638:87% (Oral), 100% (IM) 6024:? (+++ in dysthymia) 3435:Rhône-Poulenc/Aventis 2411:Aripiprazole lauroxil 2294:nigrostriatal pathway 2241:nigrostriatal pathway 2190:dopaminergic pathways 2116:Aripiprazole lauroxil 1950:theienobenzodiazepine 1936:complete blood counts 1420:Typical antipsychotic 1384: 1376: 1368: 1226:Myocardial infarction 811:Typicals vs atypicals 695:personality disorders 538:outpatient commitment 27472:Dopamine antagonists 27431:Kay Redfield Jamison 27416:Frederick K. Goodwin 27236:Valproate semisodium 27126:Psychotic depression 26634:Desmethoxyfallypride 25845:Propylnorapomorphine 25644:Alentemol (U-66444B) 25116:Propylnorapomorphine 24762:Radiopharmaceuticals 24550:Antiparkinson agents 22899:10.1056/nejmoa061240 22581:Psychiatric Services 22087:Psychiatric Services 21051:"Medscape home page" 20956:receptor activity". 20698:10.1155/2016/3081704 18182:Li M (August 2016). 17172:10.1155/2016/8213165 16356:(6 September 2022). 16144:Current Drug Targets 15680:10.4088/PCC.17r02185 15364:(Suppl 1): S61–S66. 15150:Psychiatric Services 15114:10.1056/NEJMoa051688 14342:. 10 November 2022. 14036:(5 Suppl B): S1-20. 13375:10.4088/JCP.11m06878 13079:dailymed.nlm.nih.gov 12617:Molecular Psychiatry 12580:10.1093/ijnp/pyaa004 12233:Molecular Psychiatry 12138:. 12 February 2014. 12048:: 1745506518762664. 11428:(10027): 1561–1572. 11062:Antipsychotics abuse 10803:rational drug design 9297:8.85–11.7 ng/mL 9123:Oral, IM, Inhalation 8675:Dehydroaripiprazole 3931:(ORs & 95% CIs) 3771:Bristol-Myers Squibb 2859:Bristol-Myers Squibb 2233:mesocortical pathway 1974:(Seroquel) – Of the 1256:in individuals with 1103:Reduced perspiration 660:) have received the 371:Psychotic depression 27:Class of medications 27354:Clinical psychology 27169:Hypomania Checklist 27007:Atypical depression 26774:Tetrahydropalmatine 25507:Dihydroergocryptine 25146:Tetrahydropalmatine 24949:Dihydroergocryptine 24545:Antimigraine agents 24535:Antidementia agents 24438:Anti-inflammatories 24128:Medicated dressings 24068:Antihyperlipidemics 23895:Diabetes medication 22396:The Washington Post 22378:. 12 November 2009. 22255:10.2147/PPA.S235104 21944:Psychiatry Volume 2 20749:10.2147/NDT.S227196 20476:10.2147/TCRM.S31484 20422:(9799): 1306–1315. 19943:10.1100/2012/512047 19018:European Psychiatry 16938:10.1038/tp.2012.116 16769:10.1192/apt.11.2.92 16515:2012PLoSO...733548W 15896:10.5694/mja16.00650 14552:. 17 January 2007. 11335:Psychiatry Research 11284:Burnett GB (1975). 11184:Special populations 10959:is often used as a 10942:Society and culture 9960: 9910:Faeces, urine (10%) 9212:89539 ± 37001 ng/mL 8589:Active metabolites 8550:(active metabolite) 6001:Bipolar maintenance 5927:Confidence Interval 4819:Parkinson's disease 4015:blood–brain barrier 4011:Torsades de Pointes 3861:Clopixol/Cisordinol 3627:Delagrange/Fujisawa 3285:Neuleptil/Neulactil 3075:Novartis-Boehringer 2487:Pyridinylpiperazine 2165:Mechanism of action 2026:Parkinson's disease 1948:(Zyprexa) – Of the 1809:hyperprolactinaemia 1210:Torsades de pointes 1056:Hyperprolactinaemia 669:unipolar depression 515:Maintenance therapy 297:, originating from 291:serotonin receptors 174:major tranquilizers 27347:Non-pharmaceutical 24398:Immunosuppressants 24268:Antimycobacterials 24224:Antithyroid agents 24208:Mineralocorticoids 24012:Cardiac stimulants 24002:Cardiac glycosides 23994:cardiac therapy / 23890:Anti-obesity drugs 23774:Never to phase III 22516:(September 2013). 22446:The New York Times 22429:on 5 October 2010. 22421:The New York Times 22302:Current Psychiatry 21806:"tranquillizer, n" 21375:10.1007/BF00558453 21210:10.1007/BF00545974 20854:on 8 November 2013 20457:Citrome L (2013). 19724:10.2147/NDT.S34433 19127:(Suppl 10): 42–6. 19092:Shorter E (2009). 18123:(Suppl. 3): 9–13. 17694:10.1176/foc.2.1.48 15450:(September 2013). 15315:Neuropsychobiology 14254:(10347): 170–184. 13828:10.1111/acps.13628 12246:10.1038/mp.2012.47 11395:10.1093/bmb/ldv017 10953:major tranquilizer 10917:nonbenzodiazepines 10911:drugs such as the 10839:Cibapharmaceutical 10783: 10771: 10722:aqueous suspension 10488:Trilafon Enanthate 10338:Olanzapine pamoate 10234:Prolixin Enanthate 10197:Prolixin Decanoate 9931: 9431:7-OH perphenazine 8829:102–771 ng/mL 8586:Metabolism enzymes 5998:Bipolar depression 2661:Clofekton/Padrasen 2198:mesolimbic pathway 2062:as opposed to the 2028:psychosis in 2016. 2020:– A selective 5-HT 1387: 1379: 1371: 1331:Tardive dyskinesia 1289:cognitive function 1287:Adverse effect on 1139:Metabolic syndrome 1109:Tardive dyskinesia 1048:Pseudoparkinsonism 966:pulmonary embolism 932:tardive dyskinesia 912:metabolic syndrome 882:tardive dyskinesia 713:may be useful for 630:black-box warnings 543:Antipsychotics in 454:cognitive symptoms 261:tardive akathisia. 253:tardive dyskinesia 245:metabolic syndrome 200:), principally in 198:disordered thought 106:, irritability in 27444: 27443: 27397: 27396: 27321:Lithium carbonate 27267:Dextroamphetamine 27085:Suicidal ideation 27046: 27045: 26875: 26874: 26868: 26859: 26850: 26841: 26832: 26823: 26814: 26797: 26796: 26704:N-Methylspiperone 26562:Trimethobenzamide 25622: 25614: 25606: 25411: 25410: 25069: 25061: 25048: 24854:Dopamine receptor 24820: 24819: 24723:Ophthalmologicals 24433:Anabolic steroids 24336:Anticancer agents 24299:Ectoparasiticides 24019:Antihypertensives 23967:Antifibrinolytics 23784: 23783: 23608:Phenylpiperazines 22571:978-0-89042-336-3 22296:Bogart G (2011). 22056:978-0-19-955712-7 22030:978-1-4496-1356-3 21982:978-0-7817-2468-5 21953:978-0-7216-5257-3 21942:Tasman A (1997). 21877:978-0-521-63353-6 21850:978-0-387-34707-3 21686:10.1159/000468580 19597:978-0-85711-084-8 19572:978-0-9805790-9-3 19547:978-0-8155-1856-3 19520:978-0-8155-1856-3 19493:978-0-8155-1526-5 19466:978-0-8155-1856-3 19258:978-0-12-813428-3 19105:978-0-19-536874-1 18999:978-3-527-66447-4 18876:978-0-8103-7177-4 18785:978-0-8155-1856-3 18755:978-0-8155-1856-3 18728:978-3-642-61007-3 18500:978-1-4200-4177-4 18468:978-3-527-60749-5 18437:978-84-9788-424-2 18160:978-3-642-25760-5 18108:Stahl SM (2003). 17926:978-3-8055-5050-5 17917:10.1159/000418015 17808:(23): 2437–2445. 17617:(Suppl 6): 10–3. 17590:(Suppl 4): 21–6. 17547:(12): 1511–1518. 17525:978-88-470-2679-7 17452:978-0-19-852748-0 17413:978-0-85369-845-6 16483:978-0-07-162442-8 16324:(Suppl 2): 20–3. 16150:(12): 1402–1411. 15763:978-1-4441-6494-7 15719:10.1002/wps.20579 15631:(12): 1511–1518. 15504:978-0-89042-336-3 15327:10.1159/000135641 15279:Owens DC (2008). 14624:. 18 April 2023. 14575:James AC (2010). 14548:(Press release). 14314:978-0-89042-319-6 14115:10.1345/aph.1Q697 13870:(10): 1064–1076. 13547:(February 2014). 13443:(2 Suppl): 1–56. 13369:(11): 1452–1464. 13233:10.2147/ndt.s1162 13041:Bipolar Disorders 13024:978-0-7817-6555-8 12438:10.1002/wps.20514 12158:Psychiatry Online 12099:10.1002/phar.1529 12001:(11): 1177–1193. 11944:978-0-470-97948-8 11266:978-0-7817-7155-9 11133:'s antipsychotic 11090:) has been used. 10758: 10757: 10636:Clopixol Acuphase 10451:Trilafon Dekanoat 10086:Impromen Decanoas 9929: 9928: 9925: 9924: 9562:partial agonist) 9550:Norquetiapine (a 9258:4–20.4 mg/mL 8663:(including depot) 8525:Pharmacokinetics 8520: 8519: 8516: 8515: 8511: 8510: 6373:Binding affinity 6368: 6367: 5989:Generic drug name 5979: 5978: 5974: 5973: 5218:) antipsychotic. 4554:) antipsychotic. 4485:) antipsychotic. 4291:) antipsychotic. 3896:(OR with 95% CI) 3877: 3876: 3873: 3872: 3795:Sanofi-Synthélabo 3699:Sanofi-Synthélabo 3123:Mitsubishi Pharma 2949:Nozinan/Levoprome 2589:Defecton/Prazinil 2379:Sanofi-Synthélabo 1976:dibenzothiazepine 1870:Tourette syndrome 1352:City and Hackney 1242:Long-term effects 1147:African Americans 936:tardive psychosis 699:Tourette syndrome 450:negative symptoms 446:positive symptoms 414:is used to treat 396:Tourette syndrome 176:, are a class of 163: 162: 100:Tourette syndrome 68:Class identifiers 16:(Redirected from 27479: 27336:Lithium toxicity 27298:mood stabilizers 27248:Sympathomimetics 27231:Sodium valproate 27199: 27198: 26926:Bipolar disorder 26922: 26921: 26902: 26895: 26888: 26879: 26878: 26862: 26853: 26844: 26835: 26826: 26817: 26805: 26684:Levofenfluramine 26552:Thiethylperazine 26229:+tranylcypromine 26160:Prochlorperazine 25975:Chlorproethazine 25620: 25612: 25607:-DOPA (levodopa) 25604: 25426: 25425: 25260:+tranylcypromine 25067: 25059: 25049:-DOPA (levodopa) 25046: 24874: 24873: 24847: 24840: 24833: 24824: 24823: 24809: 24788: 24787: 24772:Senotherapeutics 24626:Neuroprotectives 24621:Mood stabilizers 24520:Anti-ADHD agents 24460:Muscle relaxants 24393:Immunostimulants 24388:Immunomodulators 24220:Thyroid hormones 24158:Fertility agents 24061:Renin inhibitors 23952:Antihemorrhagics 23919:forming organs ( 23905:Dietary minerals 23811: 23804: 23797: 23788: 23787: 23550:benzisothiazoles 23310:Prochlorperazine 23070: 23063: 23056: 23047: 23046: 23027: 22974: 22964: 22922: 22919: 22901: 22876: 22866: 22841: 22839: 22837: 22815: 22809: 22801: 22791: 22757: 22755: 22753: 22724: 22718: 22715: 22697: 22680:(12): CD008634. 22664: 22647: 22637: 22604: 22575: 22547: 22545: 22543: 22510: 22499: 22498: 22492: 22484: 22456: 22450: 22449: 22437: 22431: 22430: 22428: 22423:. Archived from 22412: 22401: 22400: 22386: 22380: 22379: 22368: 22362: 22361: 22353: 22347: 22346: 22343:Chemist+Druggist 22335: 22329: 22328: 22316: 22310: 22309: 22293: 22278: 22277: 22267: 22257: 22233: 22227: 22221: 22215: 22209: 22203: 22202: 22192: 22182: 22158: 22152: 22151: 22149: 22147: 22136: 22130: 22129:. Imshealth.com. 22117: 22111: 22110: 22082: 22076: 22070: 22061: 22060: 22041: 22035: 22034: 22014: 22008: 21993: 21987: 21986: 21964: 21958: 21957: 21939: 21933: 21932: 21892: 21886: 21885: 21861: 21855: 21854: 21828: 21822: 21821: 21819: 21817: 21802: 21796: 21795: 21790:Healy D (2005). 21787: 21781: 21780: 21778: 21776: 21767:. Archived from 21736: 21727: 21723: 21717: 21716: 21704: 21698: 21697: 21669: 21663: 21662: 21634: 21628: 21627: 21606: 21600: 21599: 21591: 21585: 21584: 21574: 21542: 21533: 21532: 21523:(5 Pt 2): 50–9. 21512: 21506: 21505: 21497: 21488: 21487: 21459: 21450: 21449: 21437: 21431: 21428: 21422: 21421: 21401: 21395: 21394: 21358: 21352: 21351: 21315: 21309: 21308: 21271: 21265: 21264: 21236: 21230: 21229: 21193: 21187: 21186: 21167:10.1002/hup.2290 21149: 21143: 21142: 21127: 21121: 21120: 21103: 21097: 21096: 21075: 21069: 21068: 21047: 21041: 21040: 21030: 21020: 20996: 20990: 20989: 20952: 20946: 20945: 20916: 20907: 20906: 20870: 20864: 20863: 20861: 20859: 20832: 20826: 20825: 20789: 20783: 20778: 20772: 20771: 20761: 20751: 20727: 20721: 20720: 20710: 20700: 20676: 20670: 20669: 20652:(12): CD008121. 20645: 20639: 20638: 20628: 20611:(8): 1029–1049. 20599: 20593: 20592: 20556: 20550: 20549: 20539: 20529: 20505: 20499: 20498: 20488: 20478: 20454: 20448: 20447: 20410: 20404: 20403: 20401: 20399: 20384: 20378: 20377: 20367: 20335: 20329: 20328: 20292: 20286: 20285: 20275: 20243: 20237: 20236: 20226: 20198: 20192: 20191: 20174:(11): CD001949. 20167: 20161: 20160: 20150: 20118: 20112: 20111: 20109: 20107: 20091: 20082: 20081: 20045: 20039: 20038: 20028: 20000: 19994: 19993: 19991: 19989: 19975: 19966: 19965: 19955: 19945: 19921: 19915: 19914: 19877: 19871: 19870: 19860: 19828: 19822: 19821: 19811: 19779: 19773: 19772: 19770: 19768: 19753: 19747: 19746: 19736: 19726: 19702: 19693: 19692: 19656: 19645: 19644: 19608: 19602: 19601: 19583: 19577: 19576: 19558: 19552: 19551: 19531: 19525: 19524: 19504: 19498: 19497: 19477: 19471: 19470: 19450: 19444: 19443: 19441: 19439: 19420: 19414: 19413: 19402: 19396: 19395: 19385: 19357: 19351: 19350: 19340: 19312: 19306: 19305: 19269: 19263: 19262: 19242: 19233: 19232: 19230: 19228: 19209: 19203: 19202: 19191: 19185: 19184: 19173: 19167: 19166: 19164: 19162: 19143: 19137: 19136: 19116: 19110: 19109: 19089: 19080: 19079: 19077: 19075: 19056: 19050: 19049: 19013: 19004: 19003: 18983: 18977: 18976: 18966: 18943:CNS Drug Reviews 18934: 18928: 18927: 18891: 18885: 18884: 18861: 18852: 18851: 18831: 18825: 18824: 18796: 18790: 18789: 18769: 18760: 18759: 18739: 18733: 18732: 18712: 18703: 18702: 18700: 18698: 18679: 18673: 18672: 18670: 18668: 18649: 18643: 18642: 18631: 18625: 18624: 18613: 18607: 18606: 18595: 18589: 18588: 18560: 18505: 18504: 18484: 18473: 18472: 18452: 18446: 18445: 18421: 18324: 18323: 18313: 18303: 18279: 18273: 18272: 18262: 18252: 18228: 18222: 18221: 18211: 18179: 18173: 18172: 18138: 18132: 18131: 18129: 18114: 18105: 18096: 18095: 18085: 18061: 18055: 18054: 18026: 18020: 18019: 17991: 17982: 17981: 17945: 17939: 17938: 17900: 17894: 17893: 17865: 17859: 17858: 17856: 17854: 17840: 17834: 17833: 17793: 17787: 17786: 17750: 17744: 17743: 17707: 17698: 17697: 17673: 17667: 17666: 17664: 17662: 17651: 17645: 17644: 17633: 17627: 17626: 17606: 17600: 17599: 17579: 17573: 17572: 17536: 17530: 17529: 17509: 17503: 17502: 17466: 17457: 17456: 17436: 17421: 17420: 17399: 17393: 17392: 17382: 17350: 17344: 17343: 17333: 17301: 17295: 17294: 17284: 17274: 17250: 17244: 17243: 17233: 17201: 17195: 17194: 17184: 17174: 17150: 17144: 17143: 17125: 17105: 17099: 17098: 17088: 17056: 17050: 17049: 17031: 17022:(9): 1649–1661. 17007: 17001: 17000: 16990: 16966: 16960: 16959: 16949: 16917: 16911: 16910: 16900: 16868: 16862: 16861: 16851: 16827: 16821: 16820: 16784: 16778: 16777: 16771: 16747: 16741: 16740: 16734: 16726: 16716: 16684: 16678: 16677: 16667: 16643: 16637: 16636: 16600: 16594: 16593: 16553: 16547: 16546: 16536: 16526: 16494: 16488: 16487: 16467: 16456: 16455: 16430:(2–3): 299–300. 16415: 16409: 16408: 16368: 16362: 16361: 16350: 16344: 16343: 16333: 16309: 16303: 16302: 16292: 16282: 16258: 16252: 16251: 16241: 16209: 16203: 16202: 16182: 16176: 16175: 16139: 16133: 16132: 16122: 16090: 16084: 16083: 16047: 16041: 16040: 16012: 16006: 16005: 15968: 15962: 15961: 15936:(4): e434–e438. 15925: 15916: 15915: 15879: 15873: 15872: 15862: 15839:Pharmacogenomics 15830: 15824: 15823: 15813: 15781: 15772: 15771: 15747: 15741: 15740: 15730: 15707:World Psychiatry 15698: 15692: 15691: 15663: 15657: 15656: 15620: 15614: 15613: 15603: 15579: 15570: 15567: 15538: 15536: 15534: 15515:(30 June 2013). 15513:Joint Commission 15508: 15481: 15479: 15477: 15444: 15433: 15432: 15396: 15390: 15389: 15353: 15347: 15346: 15309: 15303: 15302: 15300: 15276: 15270: 15269: 15241: 15235: 15234: 15198: 15192: 15191: 15181: 15141: 15135: 15134: 15116: 15092: 15086: 15085: 15048: 15042: 15041: 15031: 14999: 14993: 14992: 14956: 14950: 14949: 14939: 14915: 14909: 14908: 14898: 14874: 14868: 14867: 14857: 14825: 14819: 14818: 14808: 14806:10.7326/M19-1859 14784: 14778: 14777: 14740: 14734: 14733: 14697: 14691: 14690: 14672: 14648: 14642: 14641: 14614: 14608: 14605: 14599: 14598: 14596: 14572: 14566: 14565: 14563: 14561: 14542: 14536: 14535: 14499: 14493: 14492: 14482: 14458: 14452: 14451: 14415: 14409: 14408: 14398: 14366: 14360: 14359: 14332: 14326: 14325: 14323: 14321: 14298: 14292: 14291: 14273: 14263: 14239: 14233: 14232: 14214: 14190: 14184: 14183: 14173: 14141: 14135: 14134: 14098: 14092: 14091: 14075: 14066: 14065: 14055: 14045: 14021: 14012: 14011: 13971: 13965: 13964: 13954: 13936: 13912: 13906: 13905: 13887: 13855: 13849: 13848: 13830: 13806: 13800: 13799: 13797: 13795: 13789: 13778: 13770: 13764: 13761: 13755: 13754: 13744: 13734: 13710: 13704: 13703: 13686:(12): CD008121. 13679: 13670: 13669: 13659: 13627: 13621: 13620: 13610: 13582: 13576: 13574: 13572: 13570: 13541: 13535: 13534: 13524: 13500: 13487: 13486: 13484: 13482: 13459: 13453: 13452: 13432: 13426: 13425: 13393: 13387: 13386: 13357: 13351: 13350: 13340: 13330: 13306: 13300: 13299: 13274:(7): 1281–1290. 13262: 13256: 13255: 13245: 13235: 13211: 13205: 13204: 13187:(1–3): 196–201. 13176: 13170: 13169: 13167: 13165: 13145: 13139: 13138: 13120: 13096: 13090: 13089: 13087: 13085: 13071: 13065: 13064: 13035: 13029: 13028: 13010: 13001: 13000: 12990: 12966: 12960: 12959: 12952: 12946: 12945: 12935: 12903: 12894: 12893: 12857: 12851: 12850: 12840: 12816: 12807: 12806: 12788: 12756: 12747: 12746: 12710: 12704: 12703: 12678:(9896): 951–62. 12666: 12643: 12642: 12632: 12608: 12602: 12601: 12591: 12559: 12553: 12552: 12542: 12525:(6): 1227–1236. 12510: 12504: 12503: 12493: 12469: 12460: 12459: 12449: 12426:World Psychiatry 12417: 12411: 12410: 12408: 12406: 12391: 12385: 12384: 12374: 12350: 12344: 12343: 12333: 12309: 12303: 12302: 12292: 12268: 12259: 12258: 12248: 12224: 12218: 12217: 12181: 12162: 12161: 12150: 12144: 12143: 12132: 12119: 12118: 12082: 12076: 12075: 12065: 12033: 12027: 12026: 11990: 11984: 11983: 11981: 11979: 11960: 11949: 11948: 11930: 11913: 11912: 11883: 11877: 11876: 11840: 11825: 11824: 11814: 11790: 11769: 11768: 11758: 11726: 11717: 11716: 11680: 11674: 11673: 11645: 11639: 11636: 11630: 11627: 11621: 11610: 11604: 11603: 11593: 11576:(8): 1494–1501. 11561: 11552: 11551: 11526:(9): 1409–1422. 11515: 11506: 11505: 11495: 11463: 11454: 11453: 11417: 11411: 11410: 11397: 11373: 11367: 11366: 11329: 11306: 11305: 11281: 11275: 11274: 11250: 11231: 11228: 11162:Joseph Biederman 11099:Joanna Moncrieff 11056:Recreational use 11003:Overprescription 10864: 10715:Microcrystalline 10599:Risperdal Consta 10433:25–139 days 10342:Zyprexa Relprevv 10308:Haldol Decanoate 10219:14–100 days 10049:Abilify Maintena 9961: 9959: 9952: 9945: 9938: 9930: 9669: 9668:2.72 ± 0.66 L/kg 9480:Prochlorperazine 9306:Oral, IM (depot) 9223: 9219: 9213: 9209: 9208:1132 ± 814 ng/mL 9197: 8685:35% (sublingual) 8613: 8531: 8530: 8522: 8521: 8475: 8168:>10,000 (RB) 7815:Prochlorperazine 6379: 6378: 6370: 6369: 5981: 5980: 5937:QTc – Corrected 5903: 5825: 5824: 5820: 5815: 5793: 5792: 5788: 5783: 5760: 5759: 5755: 5750: 5710: 5709: 5705: 5700: 5651:to antibiotics. 5619: 5618: 5614: 5609: 5569: 5568: 5564: 5559: 5537: 5536: 5532: 5527: 5504: 5503: 5499: 5494: 5472: 5471: 5467: 5462: 5446:(dose-dependent) 5437: 5436: 5432: 5427: 5413:aplastic anaemia 5351: 5350: 5346: 5341: 5318: 5317: 5313: 5308: 5261:Prochlorperazine 5186: 5185: 5181: 5176: 5136: 5135: 5131: 5126: 5012: 5011: 5007: 5002: 4980: 4979: 4975: 4970: 4957:(dose dependent) 4945: 4944: 4940: 4935: 4913: 4912: 4908: 4903: 4880: 4879: 4875: 4870: 4761: 4760: 4756: 4751: 4728: 4727: 4723: 4718: 4678: 4677: 4673: 4668: 4609: 4608: 4604: 4599: 4576: 4575: 4571: 4566: 4540: 4539: 4535: 4530: 4507: 4506: 4502: 4497: 4453: 4452: 4448: 4443: 4313: 4312: 4308: 4303: 4259: 4258: 4254: 4249: 4190: 4189: 4185: 4180: 4157: 4156: 4152: 4147: 4115: 4114: 4110: 4105: 4076: 4075: 4071: 4066: 4000: 3999: 3995: 3990: 3967: 3966: 3962: 3957: 3928:QTc prolongation 3879: 3878: 3443:Prochlorperazine 2997:Loxitane/Loxapac 2559:Phenylpiperazine 2336: 2335: 2327: 2326: 2160:partial agonist. 2047:Third-generation 1958:bipolar disorder 1874:anxiety disorder 1805:aplastic anaemia 1797:– Used in Japan. 1677:Disputed/unknown 1582:Prochlorperazine 955:white blood cell 844:white blood cell 707:eating disorders 563:mood stabilizers 557:Bipolar disorder 551:Bipolar disorder 365:Bipolar disorder 320: 319: 308: 307: 257:tardive dystonia 210:bipolar disorder 206:mood stabilizers 147: 128: 104:Bipolar disorder 53: 32: 31: 21: 27487: 27486: 27482: 27481: 27480: 27478: 27477: 27476: 27447: 27446: 27445: 27440: 27393: 27342: 27331:Lithium sulfate 27326:Lithium citrate 27291: 27282:Methylphenidate 27251: 27242: 27203:Anticonvulsants 27188: 27140: 27131:Racing thoughts 27042: 27026: 26978: 26911: 26906: 26876: 26871: 26793: 26569:Antidepressants 26235:Triflupromazine 26225:Trifluoperazine 26205:Thioproperazine 25985:Chlorprothixene 25919: 25580:Phenethylamines 25420: 25407: 25256:Trifluoperazine 25206:Chlorprothixene 25180: 25150: 25017:Phenethylamines 24868: 24859: 24851: 24821: 24816: 24812:Medicine portal 24776: 24732: 24704: 24699: 24691:Cough medicines 24686:Bronchodilators 24667: 24660: 24540:Antidepressants 24530:Anticonvulsants 24478: 24469: 24465:Bisphosphonates 24455:Corticosteroids 24417: 24404: 24376: 24367: 24351:Spindle poisons 24341:Antimetabolites 24324: 24315: 24237: 24228: 24203:Glucocorticoids 24198:Corticosteroids 24179: 24172: 24139: 24132: 24089: 24007:Antiarrhythmics 23980: 23973: 23930:Antithrombotics 23918: 23909: 23885:Antipropulsives 23881:Antidiarrhoeals 23858: 23829: 23821: 23815: 23785: 23780: 23779: 23764:Clinical trials 23743: 23736:Others/unknown: 23701: 23531: 23408: 23358:Chlorprothixene 23345:Triflupromazine 23340:Trifluoperazine 23330:Thioproperazine 23084: 23074: 23026:(in Portuguese) 23025: 22982: 22977: 22930: 22928:Further reading 22925: 22892:(15): 1525–38. 22857:(12): 1359–69. 22835: 22833: 22803: 22802: 22751: 22749: 22741:ABIM Foundation 22737:Choosing Wisely 22725: 22721: 22572: 22541: 22539: 22527:ABIM Foundation 22523:Choosing Wisely 22511: 22502: 22486: 22485: 22457: 22453: 22438: 22434: 22413: 22404: 22387: 22383: 22370: 22369: 22365: 22354: 22350: 22337: 22336: 22332: 22317: 22313: 22294: 22281: 22234: 22230: 22222: 22218: 22210: 22206: 22159: 22155: 22145: 22143: 22138: 22137: 22133: 22127:Wayback Machine 22118: 22114: 22083: 22079: 22071: 22064: 22057: 22043: 22042: 22038: 22031: 22015: 22011: 21994: 21990: 21983: 21967:Ayd FJ (2000). 21965: 21961: 21954: 21940: 21936: 21893: 21889: 21878: 21862: 21858: 21851: 21829: 21825: 21815: 21813: 21804: 21803: 21799: 21788: 21784: 21774: 21772: 21737: 21730: 21724: 21720: 21705: 21701: 21670: 21666: 21635: 21631: 21618:(11): 1689–98. 21607: 21603: 21592: 21588: 21543: 21536: 21513: 21509: 21498: 21491: 21460: 21453: 21438: 21434: 21429: 21425: 21402: 21398: 21359: 21355: 21316: 21312: 21272: 21268: 21237: 21233: 21194: 21190: 21150: 21146: 21129: 21128: 21124: 21105: 21104: 21100: 21077: 21076: 21072: 21049: 21048: 21044: 20997: 20993: 20953: 20949: 20928:(2–3): 160–70. 20917: 20910: 20871: 20867: 20857: 20855: 20843: 20833: 20829: 20790: 20786: 20779: 20775: 20728: 20724: 20677: 20673: 20646: 20642: 20600: 20596: 20557: 20553: 20506: 20502: 20455: 20451: 20411: 20407: 20397: 20395: 20386: 20385: 20381: 20350:(1): CD003545. 20336: 20332: 20293: 20289: 20258:(3): CD001944. 20244: 20240: 20209:(4): CD007811. 20199: 20195: 20168: 20164: 20133:(3): CD003443. 20119: 20115: 20105: 20103: 20092: 20085: 20046: 20042: 20011:(1): CD002832. 20001: 19997: 19987: 19985: 19977: 19976: 19969: 19922: 19918: 19889:(1–3): 188–94. 19878: 19874: 19843:(4): CD001943. 19829: 19825: 19794:(7): CD006352. 19780: 19776: 19766: 19764: 19755: 19754: 19750: 19703: 19696: 19657: 19648: 19609: 19605: 19598: 19584: 19580: 19573: 19559: 19555: 19548: 19532: 19528: 19521: 19505: 19501: 19494: 19478: 19474: 19467: 19451: 19447: 19437: 19435: 19422: 19421: 19417: 19404: 19403: 19399: 19368:(5): CD007479. 19358: 19354: 19323:(1): CD002832. 19313: 19309: 19270: 19266: 19259: 19243: 19236: 19226: 19224: 19211: 19210: 19206: 19193: 19192: 19188: 19175: 19174: 19170: 19160: 19158: 19145: 19144: 19140: 19117: 19113: 19106: 19090: 19083: 19073: 19071: 19058: 19057: 19053: 19014: 19007: 19000: 18984: 18980: 18935: 18931: 18892: 18888: 18877: 18863: 18862: 18855: 18832: 18828: 18797: 18793: 18786: 18770: 18763: 18756: 18740: 18736: 18729: 18713: 18706: 18696: 18694: 18681: 18680: 18676: 18666: 18664: 18651: 18650: 18646: 18633: 18632: 18628: 18615: 18614: 18610: 18597: 18596: 18592: 18561: 18508: 18501: 18485: 18476: 18469: 18453: 18449: 18438: 18422: 18327: 18280: 18276: 18229: 18225: 18180: 18176: 18161: 18139: 18135: 18127: 18112: 18106: 18099: 18062: 18058: 18037:(25): 2209–22. 18027: 18023: 17992: 17985: 17946: 17942: 17927: 17901: 17897: 17876:(15): 1715–36. 17866: 17862: 17852: 17850: 17842: 17841: 17837: 17794: 17790: 17751: 17747: 17708: 17701: 17674: 17670: 17660: 17658: 17653: 17652: 17648: 17634: 17630: 17607: 17603: 17580: 17576: 17537: 17533: 17526: 17510: 17506: 17467: 17460: 17453: 17437: 17424: 17414: 17400: 17396: 17351: 17347: 17302: 17298: 17251: 17247: 17202: 17198: 17151: 17147: 17123:10.1.1.618.3326 17106: 17102: 17057: 17053: 17008: 17004: 16981:(10): 2325–33. 16967: 16963: 16918: 16914: 16869: 16865: 16828: 16824: 16785: 16781: 16748: 16744: 16728: 16727: 16685: 16681: 16644: 16640: 16601: 16597: 16562:Pharmacotherapy 16554: 16550: 16495: 16491: 16484: 16468: 16459: 16416: 16412: 16377:Pharmacotherapy 16369: 16365: 16351: 16347: 16310: 16306: 16259: 16255: 16210: 16206: 16183: 16179: 16140: 16136: 16095:"Schizophrenia" 16091: 16087: 16058:(11): 1709–31. 16048: 16044: 16013: 16009: 15969: 15965: 15926: 15919: 15880: 15876: 15831: 15827: 15782: 15775: 15764: 15748: 15744: 15699: 15695: 15664: 15660: 15621: 15617: 15584:"Schizophrenia" 15580: 15573: 15532: 15530: 15505: 15485: 15475: 15473: 15461:ABIM Foundation 15457:Choosing Wisely 15445: 15436: 15397: 15393: 15354: 15350: 15310: 15306: 15277: 15273: 15242: 15238: 15199: 15195: 15142: 15138: 15107:(12): 1209–23. 15093: 15089: 15049: 15045: 15014:(1): CD000059. 15000: 14996: 14957: 14953: 14937:10.1.1.602.7571 14916: 14912: 14879:"Schizophrenia" 14875: 14871: 14826: 14822: 14785: 14781: 14741: 14737: 14698: 14694: 14649: 14645: 14616: 14615: 14611: 14606: 14602: 14573: 14569: 14559: 14557: 14544: 14543: 14539: 14510:(5): e1312–21. 14500: 14496: 14459: 14455: 14416: 14412: 14367: 14363: 14334: 14333: 14329: 14319: 14317: 14315: 14299: 14295: 14240: 14236: 14191: 14187: 14142: 14138: 14099: 14095: 14076: 14069: 14022: 14015: 13972: 13968: 13913: 13909: 13856: 13852: 13807: 13803: 13793: 13791: 13787: 13776: 13772: 13771: 13767: 13762: 13758: 13725:(3): e1001403. 13711: 13707: 13680: 13673: 13642:(8): CD008634. 13628: 13624: 13593:(1): CD003476. 13583: 13579: 13568: 13566: 13558:ABIM Foundation 13554:Choosing Wisely 13542: 13538: 13501: 13490: 13480: 13478: 13464:"Schizophrenia" 13460: 13456: 13433: 13429: 13400:(1): CD004367. 13394: 13390: 13358: 13354: 13307: 13303: 13263: 13259: 13212: 13208: 13177: 13173: 13163: 13161: 13146: 13142: 13097: 13093: 13083: 13081: 13073: 13072: 13068: 13036: 13032: 13025: 13011: 13004: 12967: 12963: 12954: 12953: 12949: 12904: 12897: 12858: 12854: 12817: 12810: 12771:(8): CD008016. 12757: 12750: 12711: 12707: 12667: 12646: 12609: 12605: 12560: 12556: 12511: 12507: 12470: 12463: 12418: 12414: 12404: 12402: 12393: 12392: 12388: 12351: 12347: 12318:JAMA Psychiatry 12310: 12306: 12269: 12262: 12239:(12): 1206–27. 12225: 12221: 12182: 12165: 12152: 12151: 12147: 12134: 12133: 12122: 12087:Pharmacotherapy 12083: 12079: 12034: 12030: 11991: 11987: 11977: 11975: 11968:Choosing Wisely 11962: 11961: 11952: 11945: 11931: 11916: 11884: 11880: 11851:(9657): 31–41. 11841: 11828: 11791: 11772: 11727: 11720: 11681: 11677: 11646: 11642: 11637: 11633: 11628: 11624: 11611: 11607: 11562: 11555: 11516: 11509: 11464: 11457: 11418: 11414: 11374: 11370: 11330: 11309: 11282: 11278: 11267: 11251: 11244: 11240: 11235: 11234: 11229: 11225: 11220: 11203: 11186: 11149:. In addition, 11096: 11064: 11058: 11030: 11014: 11005: 10988: 10949: 10944: 10913:benzodiazepines 10845:from the older 10810:antidepressants 10763: 10719:nanocrystalline 10692:11–21 days 10562:Piportil Medium 10547:14–21 days 10525:Piportil Longum 10430:13–33 days 10414:Invega Sustenna 10327:18–21 days 10108:21–25 days 10071:30–47 days 10034:54–57 days 10028:24–35 days 9995: 9988: 9982: 9957: 9956: 9765:Trifluoperazine 9667: 9559: 9221: 9217: 9211: 9207: 9195: 9061:Levomepromazine 8924:12–14 L/kg 8700:20–25 L/kg 8611: 8576: 8568: 8560: 8553:Protein binding 8549: 8546: 8538:Bioavailability 8512: 8291:Trifluoperazine 8165:>10,000 (RB) 8162:>10,000 (RB) 8135:>10,000 (RB) 8126:>10,000 (RC) 8123:>10,000 (RC) 6497: 6491: 6485: 6479: 6475: 6469: 6463: 6457: 6451: 6442: 6436: 6430: 6424: 6418: 6412: 6406: 6400: 6385: 5975: 5952: 5822: 5818: 5813: 5790: 5786: 5781: 5780: 5757: 5753: 5748: 5707: 5703: 5698: 5694:Trifluoperazine 5616: 5612: 5607: 5566: 5562: 5557: 5534: 5530: 5525: 5524: 5501: 5497: 5492: 5469: 5465: 5460: 5459: 5445: 5434: 5430: 5425: 5366: 5348: 5344: 5339: 5338: 5315: 5311: 5306: 5183: 5179: 5174: 5133: 5129: 5124: 5009: 5005: 5000: 4977: 4973: 4968: 4967: 4956: 4942: 4938: 4933: 4910: 4906: 4901: 4900: 4877: 4873: 4868: 4776: 4758: 4754: 4749: 4748: 4725: 4721: 4716: 4675: 4671: 4666: 4625:Levomepromazine 4606: 4602: 4597: 4596: 4573: 4569: 4564: 4537: 4533: 4528: 4527: 4504: 4500: 4495: 4450: 4446: 4441: 4343:Agranulocytosis 4310: 4306: 4301: 4256: 4252: 4247: 4187: 4183: 4178: 4177: 4154: 4150: 4145: 4132: 4120: 4112: 4108: 4103: 4102: 4087: 4073: 4069: 4064: 3997: 3993: 3988: 3987: 3964: 3960: 3955: 3901:Anticholinergic 3892:Discontinuation 3888: 3807:Benzisothiazole 3755:Triflupromazine 3747:GlaxoSmithKline 3731:Trifluoperazine 3567:Imidazolidinone 3339:Schering-Plough 3303:Benzisothiazole 3141:Emilace/Emirace 3087:Dihydroindolone 3015:Benzisothiazole 2939:Levomepromazine 2763:Sandoz-Novartis 2685:Sordinol/Ciatyl 2627:Chlorprothixene 2565:Vraylar/Reagila 2523:Otsuka/Lundbeck 2445:Saphris/Sycrest 2325: 2318: 2314: 2310: 2302: 2291: 2286: 2279: 2273: 2246: 2226:caudate nucleus 2223: 2219: 2209: 2185: 2167: 2159: 2155: 2145: 2141: 2137: 2127: 2111: 2102: 2093: 2089: 2080: 2071: 2067: 2060:partial agonism 2056: 2049: 2023: 2008: 1940:agranulocytosis 1922: 1903: 1832: 1818: 1769: 1764: 1758: 1746: 1709: 1687: 1679: 1651:Chlorprothixene 1647: 1641: 1628:Triflupromazine 1623:Trifluoperazine 1607:Thioproperazine 1547:Levomepromazine 1516: 1510: 1486: 1433: 1427: 1422: 1416: 1363: 1307: 1301: 1299:Discontinuation 1250: 1244: 1221:Thromboembolism 1191:creatine kinase 1186:Muscle rigidity 1162: 1155: 999: 962:thromboembolism 951:agranulocytosis 905: 898: 896:Adverse effects 840:agranulocytosis 813: 766:autism spectrum 682: 673:antidepressants 650: 622: 559: 553: 517: 508: 475: 466: 430: 424: 359:mood stabilizer 339: 325:)—thus meaning 249:adverse effects 143: 63: 62:) antipsychotic 28: 23: 22: 15: 12: 11: 5: 27485: 27475: 27474: 27469: 27464: 27459: 27457:Antipsychotics 27442: 27441: 27439: 27438: 27433: 27428: 27423: 27418: 27413: 27411:Emil Kraepelin 27407: 27405: 27399: 27398: 27395: 27394: 27392: 27391: 27386: 27381: 27376: 27371: 27366: 27361: 27356: 27350: 27348: 27344: 27343: 27341: 27340: 27339: 27338: 27333: 27328: 27323: 27313: 27308: 27306:Antipsychotics 27302: 27300: 27293: 27292: 27290: 27289: 27284: 27279: 27274: 27269: 27264: 27258: 27256: 27244: 27243: 27241: 27240: 27239: 27238: 27233: 27223: 27218: 27213: 27207: 27205: 27196: 27190: 27189: 27187: 27186: 27181: 27176: 27171: 27166: 27161: 27156: 27150: 27148: 27142: 27141: 27139: 27138: 27133: 27128: 27123: 27118: 27117: 27116: 27111: 27103:Sleep disorder 27099: 27094: 27089: 27088: 27087: 27082: 27077: 27067: 27062: 27056: 27054: 27048: 27047: 27044: 27043: 27041: 27040: 27034: 27032: 27028: 27027: 27025: 27024: 27019: 27014: 27009: 27004: 26999: 26994: 26988: 26986: 26980: 26979: 26977: 26976: 26971: 26966: 26961: 26956: 26951: 26946: 26941: 26936: 26930: 26928: 26919: 26913: 26912: 26905: 26904: 26897: 26890: 26882: 26873: 26872: 26870: 26869: 26860: 26851: 26842: 26833: 26824: 26815: 26802: 26799: 26798: 26795: 26794: 26792: 26791: 26786: 26781: 26776: 26771: 26766: 26761: 26756: 26751: 26746: 26741: 26736: 26731: 26726: 26721: 26716: 26711: 26706: 26701: 26696: 26691: 26686: 26681: 26676: 26671: 26669:Isocorypalmine 26666: 26661: 26656: 26651: 26646: 26641: 26636: 26631: 26626: 26621: 26616: 26611: 26606: 26596: 26595: 26590: 26585: 26580: 26575: 26565: 26564: 26559: 26554: 26549: 26544: 26539: 26537:Metoclopramide 26534: 26529: 26524: 26519: 26514: 26512:Deudomperidone 26509: 26504: 26499: 26494: 26489: 26484: 26479: 26477:Aceprometazine 26469: 26468: 26463: 26458: 26453: 26448: 26443: 26438: 26433: 26428: 26423: 26418: 26413: 26408: 26403: 26401:Piperacetazine 26398: 26393: 26388: 26378: 26373: 26368: 26363: 26358: 26353: 26348: 26343: 26338: 26333: 26328: 26323: 26318: 26313: 26308: 26303: 26298: 26293: 26288: 26283: 26278: 26273: 26268: 26263: 26253: 26252: 26250:Zuclopenthixol 26247: 26242: 26237: 26232: 26222: 26217: 26212: 26207: 26202: 26197: 26192: 26187: 26182: 26177: 26172: 26167: 26162: 26157: 26152: 26147: 26142: 26137: 26134:+amitriptyline 26127: 26122: 26117: 26112: 26107: 26102: 26097: 26092: 26087: 26082: 26077: 26072: 26067: 26062: 26057: 26052: 26047: 26042: 26032: 26027: 26022: 26017: 26012: 26007: 26002: 25997: 25992: 25987: 25982: 25980:Chlorpromazine 25977: 25972: 25967: 25962: 25957: 25952: 25947: 25942: 25940:Acetophenazine 25937: 25927: 25925: 25921: 25920: 25918: 25917: 25912: 25907: 25902: 25897: 25892: 25887: 25882: 25877: 25872: 25867: 25862: 25857: 25852: 25847: 25842: 25837: 25832: 25827: 25822: 25817: 25812: 25807: 25802: 25797: 25792: 25787: 25782: 25777: 25772: 25767: 25762: 25757: 25752: 25747: 25742: 25737: 25732: 25727: 25722: 25717: 25712: 25707: 25697: 25696: 25691: 25686: 25681: 25676: 25671: 25666: 25661: 25656: 25646: 25636: 25635: 25630: 25625: 25617: 25615:-Phenylalanine 25609: 25601: 25596: 25591: 25586: 25576: 25575: 25570: 25565: 25560: 25555: 25545: 25544: 25539: 25534: 25529: 25524: 25519: 25514: 25509: 25504: 25499: 25494: 25484: 25483: 25478: 25473: 25468: 25463: 25457:Aminotetralins 25453: 25452: 25447: 25442: 25432: 25430: 25423: 25418: 25413: 25412: 25409: 25408: 25406: 25405: 25400: 25395: 25390: 25385: 25380: 25375: 25365: 25364: 25359: 25354: 25349: 25344: 25339: 25334: 25329: 25319: 25314: 25309: 25304: 25299: 25294: 25289: 25284: 25279: 25269: 25268: 25266:Zuclopenthixol 25263: 25253: 25248: 25243: 25238: 25235:+amitriptyline 25228: 25223: 25218: 25208: 25203: 25201:Chlorpromazine 25198: 25188: 25186: 25182: 25181: 25179: 25178: 25173: 25168: 25158: 25156: 25152: 25151: 25149: 25148: 25143: 25138: 25133: 25128: 25123: 25118: 25113: 25108: 25103: 25098: 25096:Isocorypalmine 25093: 25088: 25078: 25077: 25072: 25064: 25062:-Phenylalanine 25056: 25051: 25043: 25038: 25033: 25028: 25023: 25013: 25012: 25007: 25002: 24997: 24992: 24987: 24982: 24972: 24971: 24966: 24961: 24956: 24951: 24946: 24941: 24931: 24930: 24925: 24920: 24915: 24910: 24905: 24900: 24895: 24890: 24880: 24878: 24871: 24866: 24861: 24860: 24850: 24849: 24842: 24835: 24827: 24818: 24817: 24815: 24814: 24803: 24798: 24793: 24781: 24778: 24777: 24775: 24774: 24769: 24764: 24759: 24757:Contrast media 24754: 24748: 24746: 24734: 24733: 24731: 24730: 24725: 24719: 24717: 24710:sensory organs 24706: 24705: 24703: 24702: 24697: 24693: 24688: 24683: 24677: 24675: 24662: 24661: 24659: 24658: 24653: 24648: 24643: 24638: 24633: 24628: 24623: 24618: 24609: 24608: 24607: 24602: 24597: 24587: 24582: 24577: 24572: 24567: 24562: 24557: 24555:Antipsychotics 24552: 24547: 24542: 24537: 24532: 24527: 24525:Antiaddictives 24522: 24517: 24512: 24511: 24510: 24505: 24495: 24489: 24487: 24480:nervous system 24471: 24470: 24468: 24467: 24462: 24457: 24452: 24450:Antirheumatics 24447: 24446: 24445: 24435: 24429: 24427: 24406: 24405: 24403: 24402: 24401: 24400: 24395: 24384: 24382: 24369: 24368: 24366: 24365: 24364: 24363: 24358: 24356:Antineoplastic 24353: 24348: 24343: 24332: 24330: 24317: 24316: 24314: 24313: 24308: 24303: 24302: 24301: 24296: 24291: 24289:Antiprotozoals 24284:Antiparasitics 24281: 24276: 24271: 24264:Antibacterials 24260:Antimicrobials 24256: 24254: 24230: 24229: 24227: 24226: 24217: 24212: 24211: 24210: 24205: 24195: 24189: 24187: 24174: 24173: 24171: 24170: 24165: 24160: 24155: 24149: 24147: 24134: 24133: 24131: 24130: 24125: 24123:Antipsoriatics 24120: 24115: 24110: 24104: 24102: 24091: 24090: 24088: 24087: 24086: 24085: 24080: 24075: 24065: 24064: 24063: 24058: 24053: 24051:ACE inhibitors 24041: 24036: 24031: 24026: 24021: 24016: 24015: 24014: 24009: 24004: 23990: 23988: 23979:cardiovascular 23975: 23974: 23972: 23971: 23970: 23969: 23964: 23959: 23949: 23948: 23947: 23942: 23940:Anticoagulants 23937: 23926: 23924: 23911: 23910: 23908: 23907: 23902: 23897: 23892: 23887: 23878: 23873: 23868: 23867: 23866: 23861: 23856: 23852: 23841: 23839: 23823: 23822: 23814: 23813: 23806: 23799: 23791: 23782: 23781: 23778: 23777: 23776: 23775: 23772: 23761: 23755: 23749: 23748: 23745: 23744: 23742: 23741: 23732: 23731: 23726: 23721: 23709: 23707: 23703: 23702: 23700: 23699: 23694: 23689: 23680: 23679: 23674: 23669: 23659: 23654: 23642: 23641: 23636: 23631: 23626: 23625: 23624: 23603: 23602: 23595:Butyrophenones 23590: 23589: 23584: 23579: 23574: 23573: 23572: 23562: 23557: 23541: 23539: 23533: 23532: 23530: 23529: 23520: 23519: 23514: 23509: 23504: 23499: 23494: 23489: 23477: 23476: 23469:Butyrophenones 23464: 23463: 23458: 23453: 23448: 23443: 23438: 23433: 23428: 23416: 23414: 23410: 23409: 23407: 23406: 23405: 23404: 23399: 23392:Zuclopenthixol 23389: 23384: 23383: 23382: 23372: 23371: 23370: 23360: 23348: 23347: 23342: 23337: 23332: 23327: 23322: 23317: 23312: 23307: 23306: 23305: 23300: 23290: 23288:Piperacetazine 23285: 23284: 23283: 23278: 23273: 23263: 23258: 23253: 23248: 23243: 23242: 23241: 23236: 23226: 23221: 23216: 23214:Chlorpromazine 23211: 23206: 23201: 23199:Acetophenazine 23196: 23189:Phenothiazines 23184: 23183: 23178: 23173: 23161: 23160: 23155: 23150: 23145: 23140: 23135: 23134: 23133: 23123: 23118: 23117: 23116: 23106: 23099:Butyrophenones 23094: 23092: 23086: 23085: 23077:Antipsychotics 23073: 23072: 23065: 23058: 23050: 23044: 23043: 23023: 23017: 23011: 23005: 22999: 22993: 22981: 22980:External links 22978: 22976: 22975: 22931: 22929: 22926: 22924: 22923: 22921: 22920: 22877: 22842: 22822:(8 May 2013). 22816: 22758:, which cites 22719: 22717: 22716: 22665: 22648: 22620:(19): 2020–9. 22605: 22576: 22570: 22548:, which cites 22500: 22467:(3): 147–159. 22451: 22432: 22402: 22381: 22363: 22348: 22330: 22311: 22279: 22228: 22216: 22204: 22153: 22131: 22112: 22077: 22062: 22055: 22036: 22029: 22009: 21988: 21981: 21959: 21952: 21934: 21907:(8): 923–947. 21887: 21876: 21856: 21849: 21823: 21797: 21782: 21771:on 9 July 2017 21751:(4): 443–452. 21728: 21718: 21699: 21664: 21629: 21601: 21586: 21534: 21507: 21489: 21451: 21432: 21423: 21412:(2): 153–175. 21396: 21353: 21310: 21266: 21231: 21188: 21144: 21122: 21098: 21070: 21042: 20991: 20947: 20908: 20865: 20841: 20827: 20784: 20773: 20722: 20671: 20640: 20594: 20567:(5): 339–346. 20551: 20500: 20449: 20405: 20379: 20330: 20287: 20238: 20193: 20162: 20113: 20083: 20040: 19995: 19967: 19916: 19872: 19823: 19774: 19748: 19694: 19646: 19603: 19596: 19578: 19571: 19553: 19546: 19526: 19519: 19499: 19492: 19472: 19465: 19445: 19415: 19397: 19352: 19307: 19264: 19257: 19234: 19204: 19186: 19168: 19138: 19111: 19104: 19081: 19051: 19005: 18998: 18978: 18929: 18902:(2–3): 343–7. 18886: 18875: 18853: 18826: 18791: 18784: 18761: 18754: 18734: 18727: 18718:Antipsychotics 18704: 18674: 18644: 18626: 18608: 18590: 18571:(5): 289–304. 18506: 18499: 18474: 18467: 18447: 18436: 18325: 18294:(7): 927–940. 18274: 18223: 18194:(8): 749–770. 18174: 18159: 18133: 18097: 18076:(4): 330–336. 18056: 18021: 17983: 17956:(6): 387–400. 17940: 17925: 17895: 17860: 17835: 17798:"Aripiprazole" 17788: 17745: 17699: 17668: 17646: 17628: 17601: 17574: 17531: 17524: 17504: 17458: 17451: 17422: 17412: 17394: 17365:(9): 900–906. 17345: 17296: 17245: 17216:(5): 229–245. 17196: 17145: 17100: 17071:(5): 931–936. 17051: 17002: 16961: 16912: 16863: 16822: 16779: 16742: 16679: 16638: 16595: 16568:(9): 1123–30. 16548: 16489: 16482: 16457: 16410: 16363: 16345: 16304: 16253: 16204: 16177: 16134: 16105:(7610): 91–5. 16085: 16042: 16023:(3): 163–177. 16007: 15980:(6): 594–596. 15963: 15917: 15874: 15845:(4): 279–290. 15825: 15796:(5): 237–256. 15773: 15762: 15742: 15713:(3): 330–340. 15693: 15658: 15615: 15571: 15569: 15568: 15539: 15509: 15503: 15482:, which cites 15434: 15391: 15348: 15321:(1–2): 80–87. 15304: 15271: 15252:(3): 137–146. 15236: 15193: 15156:(5): 500–506. 15136: 15087: 15043: 14994: 14951: 14930:(12): 1821–9. 14910: 14869: 14820: 14799:(7): 474–484. 14779: 14735: 14692: 14663:(2): 119–128. 14643: 14609: 14600: 14567: 14537: 14494: 14453: 14410: 14381:(3): e053943. 14361: 14327: 14313: 14293: 14234: 14185: 14136: 14109:(5): 718–722. 14093: 14067: 14013: 13986:(5): 383–390. 13966: 13927:(4): 320–333. 13907: 13850: 13801: 13765: 13756: 13705: 13671: 13622: 13577: 13536: 13488: 13468:NCBI Bookshelf 13454: 13427: 13388: 13352: 13315:BMC Psychiatry 13301: 13257: 13206: 13171: 13140: 13111:(6): 439–448. 13091: 13066: 13030: 13023: 13002: 12961: 12947: 12918:(4): 361–375. 12895: 12852: 12808: 12748: 12721:(7): 1643–51. 12705: 12644: 12603: 12574:(4): 217–229. 12554: 12505: 12461: 12432:(2): 133–142. 12412: 12386: 12345: 12304: 12283:(7): 498–511. 12260: 12219: 12192:(5): 567–620. 12163: 12145: 12120: 12093:(2): 175–188. 12077: 12042:Women's Health 12028: 11985: 11950: 11943: 11914: 11878: 11826: 11805:(3): 168–175. 11770: 11741:(5): 488–501. 11718: 11675: 11640: 11631: 11622: 11605: 11553: 11507: 11478:(2): 128–137. 11455: 11412: 11368: 11307: 11276: 11265: 11241: 11239: 11236: 11233: 11232: 11222: 11221: 11219: 11216: 11215: 11214: 11209: 11202: 11199: 11185: 11182: 11095: 11092: 11060:Main article: 11057: 11054: 11042:deltoid muscle 11029: 11026: 11013: 11010: 11004: 11001: 10987: 10984: 10948: 10945: 10943: 10940: 10936:5HT2A receptor 10826:Pierre Deniker 10799:neurochemistry 10787:chlorpromazine 10779:chlorpromazine 10762: 10759: 10756: 10755: 10754:See template. 10731:(specifically 10699: 10698: 10696: 10693: 10690: 10687: 10684: 10681: 10676: 10671: 10670:Clopixol Depot 10668: 10662: 10661: 10659: 10656: 10653: 10650: 10647: 10642: 10637: 10634: 10628: 10627: 10625: 10622: 10619: 10616: 10613: 10610: 10605: 10600: 10597: 10591: 10590: 10588: 10585: 10582: 10579: 10576: 10573: 10568: 10563: 10560: 10554: 10553: 10551: 10548: 10545: 10542: 10541:9–10 days 10539: 10536: 10531: 10526: 10523: 10517: 10516: 10514: 10511: 10508: 10505: 10502: 10499: 10494: 10489: 10486: 10480: 10479: 10477: 10474: 10471: 10468: 10465: 10462: 10457: 10452: 10449: 10443: 10442: 10440: 10437: 10434: 10431: 10428: 10425: 10420: 10415: 10412: 10406: 10405: 10403: 10400: 10397: 10394: 10391: 10388: 10385: 10380: 10377: 10371: 10370: 10368: 10365: 10362: 10359: 10356: 10353: 10348: 10343: 10340: 10334: 10333: 10331: 10328: 10325: 10322: 10319: 10314: 10309: 10306: 10300: 10299: 10297: 10294: 10291: 10288: 10285: 10282: 10277: 10272: 10271:Imap, Redeptin 10269: 10263: 10262: 10260: 10257: 10254: 10251: 10248: 10245: 10240: 10235: 10232: 10226: 10225: 10223: 10220: 10217: 10216:1–10 days 10214: 10211: 10208: 10203: 10198: 10195: 10189: 10188: 10186: 10183: 10180: 10177: 10176:4–10 days 10174: 10171: 10166: 10161: 10158: 10152: 10151: 10149: 10146: 10143: 10140: 10137: 10134: 10129: 10124: 10123:Sordinol Depot 10121: 10115: 10114: 10112: 10109: 10106: 10103: 10100: 10097: 10092: 10087: 10084: 10078: 10077: 10075: 10072: 10069: 10066: 10063: 10060: 10055: 10050: 10047: 10041: 10040: 10038: 10035: 10032: 10029: 10026: 10023: 10018: 10013: 10010: 10004: 10003: 10000: 9997: 9993: 9990: 9986: 9983: 9980: 9977: 9974: 9971: 9968: 9965: 9955: 9954: 9947: 9940: 9932: 9927: 9926: 9923: 9922: 9919: 9914: 9911: 9908: 9905: 9902: 9899: 9896: 9893: 9890: 9888:Zuclopenthixol 9884: 9883: 9880: 9871: 9868: 9865: 9862: 9859: 9856: 9853: 9850: 9847: 9841: 9840: 9837: 9828: 9825: 9822: 9819: 9816: 9813: 9810: 9807: 9804: 9798: 9797: 9794: 9791: 9788: 9785: 9782: 9779: 9776: 9773: 9770: 9767: 9761: 9760: 9757: 9752: 9749: 9746: 9743: 9740: 9737: 9734: 9731: 9728: 9722: 9721: 9718: 9713: 9710: 9707: 9704: 9701: 9698: 9695: 9692: 9689: 9683: 9682: 9679: 9676: 9673: 9670: 9665: 9662: 9659: 9656: 9653: 9650: 9644: 9643: 9640: 9635: 9632: 9629: 9626: 9623: 9620: 9617: 9614: 9611: 9605: 9604: 9599: 9594: 9591: 9588: 9585: 9582: 9579: 9576: 9573: 9570: 9564: 9563: 9557: 9548: 9543: 9540: 9537: 9536:6–14 L/kg 9534: 9531: 9528: 9525: 9522: 9519: 9513: 9512: 9509: 9506: 9503: 9500: 9497: 9494: 9491: 9488: 9485: 9482: 9476: 9475: 9472: 9463: 9460: 9457: 9454: 9451: 9448: 9445: 9442: 9439: 9433: 9432: 9429: 9424: 9421: 9418: 9415: 9412: 9409: 9406: 9403: 9400: 9394: 9393: 9390: 9387: 9384: 9381: 9378: 9377:5.7 ng/mL 9375: 9372: 9369: 9368:1.9–2.5 h 9366: 9363: 9357: 9356: 9353: 9350: 9347: 9344: 9341: 9340:150 ng/mL 9338: 9335: 9332: 9329: 9326: 9320: 9319: 9316: 9307: 9304: 9301: 9298: 9295: 9292: 9289: 9286: 9283: 9277: 9276: 9273: 9268: 9265: 9262: 9259: 9256: 9253: 9250: 9247: 9244: 9238: 9237: 9234: 9231: 9228: 9225: 9220:(10 mg), 9218:9.9 ± 3.7 L/kg 9215: 9205: 9202: 9199: 9192: 9189: 9183: 9182: 9179: 9174: 9171: 9168: 9165: 9162: 9159: 9156: 9153: 9150: 9144: 9143: 9137: 9124: 9121: 9118: 9115: 9112: 9109: 9106: 9103: 9100: 9094: 9093: 9090: 9087: 9084: 9081: 9078: 9075: 9072: 9069: 9066: 9063: 9057: 9056: 9055:None notable. 9053: 9044: 9041: 9038: 9035: 9032: 9029: 9026: 9023: 9020: 9014: 9013: 9010: 9005: 9002: 8999: 8998:8–18 L/kg 8996: 8993: 8990: 8987: 8984: 8981: 8975: 8974: 8971: 8968: 8965: 8962: 8959: 8956: 8953: 8950: 8947: 8944: 8938: 8937: 8934: 8931: 8928: 8925: 8922: 8919: 8918:7 days (depot) 8916: 8913: 8910: 8907: 8901: 8900: 8897: 8894: 8885: 8882: 8879: 8876: 8873: 8870: 8867: 8864: 8858: 8857: 8852: 8839: 8836: 8833: 8832:4.67 L/kg 8830: 8827: 8826:1.5–2.5 h 8824: 8821: 8818: 8815: 8809: 8808: 8805: 8800: 8790: 8787: 8784: 8781: 8778: 8775: 8772: 8769: 8767:Chlorpromazine 8763: 8762: 8759: 8754: 8751: 8748: 8745: 8742: 8739: 8736: 8733: 8730: 8724: 8723: 8720: 8707: 8704: 8701: 8698: 8695: 8694:0.5–1.5 h 8692: 8689: 8686: 8683: 8677: 8676: 8673: 8664: 8657: 8654: 8651: 8648: 8645: 8642: 8639: 8636: 8630: 8629: 8626: 8623: 8620: 8617: 8614: 8609: 8606: 8603: 8600: 8597: 8591: 8590: 8587: 8584: 8581: 8578: 8574: 8570: 8566: 8562: 8558: 8554: 8551: 8544: 8540: 8535: 8527: 8526: 8518: 8517: 8514: 8513: 8509: 8508: 8504: 8503: 8500: 8497: 8492: 8491: 8490: 8487: 8484: 8481: 8473: 8470:Acronyms used: 8465: 8464: 8461: 8458: 8455: 8452: 8449: 8446: 8443: 8440: 8437: 8434: 8431: 8428: 8425: 8422: 8419: 8416: 8413: 8410: 8406: 8405: 8402: 8399: 8396: 8393: 8390: 8387: 8384: 8381: 8378: 8375: 8372: 8369: 8366: 8363: 8360: 8357: 8354: 8351: 8347: 8346: 8343: 8340: 8337: 8334: 8331: 8328: 8325: 8322: 8319: 8316: 8313: 8310: 8307: 8304: 8301: 8298: 8295: 8292: 8288: 8287: 8284: 8281: 8278: 8275: 8272: 8269: 8266: 8263: 8260: 8257: 8254: 8251: 8248: 8245: 8242: 8239: 8236: 8233: 8229: 8228: 8225: 8222: 8219: 8216: 8213: 8210: 8207: 8204: 8201: 8198: 8195: 8192: 8189: 8186: 8183: 8180: 8177: 8174: 8170: 8169: 8166: 8163: 8160: 8157: 8154: 8151: 8148: 8145: 8142: 8139: 8136: 8133: 8130: 8127: 8124: 8121: 8118: 8115: 8111: 8110: 8107: 8104: 8101: 8098: 8095: 8092: 8089: 8086: 8083: 8080: 8077: 8074: 8071: 8068: 8065: 8062: 8059: 8056: 8052: 8051: 8048: 8045: 8042: 8039: 8036: 8033: 8030: 8027: 8024: 8021: 8018: 8015: 8012: 8009: 8006: 8003: 8000: 7997: 7993: 7992: 7989: 7986: 7983: 7980: 7977: 7974: 7971: 7968: 7965: 7962: 7959: 7956: 7953: 7950: 7947: 7944: 7941: 7938: 7930: 7929: 7926: 7923: 7920: 7917: 7914: 7911: 7908: 7905: 7902: 7899: 7896: 7893: 7890: 7887: 7884: 7881: 7878: 7875: 7871: 7870: 7867: 7864: 7861: 7858: 7855: 7852: 7849: 7846: 7843: 7840: 7837: 7834: 7831: 7828: 7825: 7822: 7819: 7816: 7812: 7811: 7808: 7805: 7802: 7799: 7796: 7793: 7790: 7787: 7784: 7781: 7778: 7775: 7772: 7769: 7766: 7763: 7760: 7757: 7753: 7752: 7749: 7746: 7743: 7740: 7737: 7734: 7731: 7728: 7725: 7722: 7719: 7716: 7713: 7710: 7707: 7704: 7701: 7698: 7694: 7693: 7690: 7687: 7684: 7681: 7678: 7675: 7672: 7669: 7666: 7663: 7660: 7657: 7654: 7651: 7648: 7645: 7642: 7639: 7635: 7634: 7631: 7628: 7625: 7622: 7619: 7616: 7613: 7610: 7607: 7604: 7601: 7598: 7595: 7592: 7589: 7586: 7583: 7580: 7576: 7575: 7572: 7569: 7566: 7563: 7560: 7557: 7554: 7551: 7548: 7545: 7542: 7539: 7536: 7533: 7530: 7527: 7524: 7521: 7517: 7516: 7513: 7510: 7507: 7504: 7501: 7498: 7495: 7492: 7489: 7486: 7483: 7480: 7477: 7474: 7471: 7468: 7465: 7462: 7458: 7457: 7454: 7451: 7448: 7445: 7442: 7439: 7436: 7433: 7430: 7427: 7424: 7421: 7418: 7415: 7412: 7409: 7406: 7403: 7399: 7398: 7395: 7392: 7389: 7386: 7383: 7380: 7377: 7374: 7371: 7368: 7365: 7362: 7359: 7356: 7353: 7350: 7347: 7344: 7336: 7335: 7332: 7329: 7326: 7323: 7320: 7317: 7314: 7311: 7308: 7305: 7302: 7299: 7296: 7293: 7290: 7287: 7284: 7281: 7277: 7276: 7273: 7270: 7267: 7264: 7261: 7258: 7255: 7252: 7249: 7246: 7243: 7240: 7237: 7234: 7231: 7228: 7225: 7222: 7218: 7217: 7214: 7211: 7208: 7205: 7202: 7199: 7196: 7193: 7190: 7187: 7184: 7181: 7178: 7175: 7172: 7169: 7166: 7163: 7159: 7158: 7155: 7152: 7149: 7146: 7143: 7140: 7137: 7134: 7131: 7128: 7125: 7122: 7119: 7116: 7113: 7110: 7107: 7104: 7100: 7099: 7096: 7093: 7090: 7087: 7084: 7081: 7078: 7075: 7072: 7069: 7066: 7063: 7060: 7057: 7054: 7051: 7048: 7045: 7038: 7037: 7034: 7031: 7028: 7025: 7022: 7019: 7016: 7013: 7010: 7007: 7004: 7001: 6998: 6995: 6992: 6989: 6986: 6983: 6975: 6974: 6971: 6968: 6965: 6962: 6959: 6956: 6953: 6950: 6947: 6944: 6941: 6938: 6935: 6932: 6929: 6926: 6923: 6920: 6916: 6915: 6912: 6909: 6906: 6903: 6900: 6897: 6894: 6891: 6888: 6885: 6882: 6879: 6876: 6873: 6870: 6867: 6864: 6861: 6860:Chlorpromazine 6857: 6856: 6853: 6850: 6847: 6844: 6841: 6838: 6835: 6832: 6829: 6826: 6823: 6820: 6817: 6814: 6811: 6808: 6805: 6802: 6794: 6793: 6790: 6787: 6784: 6781: 6778: 6775: 6772: 6769: 6766: 6763: 6760: 6757: 6754: 6751: 6748: 6745: 6742: 6739: 6735: 6734: 6731: 6728: 6725: 6722: 6719: 6716: 6713: 6710: 6707: 6704: 6701: 6698: 6695: 6692: 6689: 6686: 6683: 6680: 6676: 6675: 6672: 6669: 6666: 6663: 6660: 6657: 6654: 6651: 6648: 6645: 6642: 6639: 6636: 6633: 6630: 6627: 6624: 6621: 6617: 6616: 6613: 6610: 6607: 6604: 6601: 6598: 6595: 6592: 6589: 6586: 6583: 6580: 6577: 6574: 6571: 6568: 6565: 6562: 6558: 6557: 6554: 6551: 6548: 6545: 6542: 6539: 6536: 6533: 6530: 6527: 6524: 6521: 6518: 6515: 6512: 6509: 6506: 6503: 6499: 6498: 6495: 6492: 6489: 6486: 6483: 6480: 6477: 6473: 6470: 6467: 6464: 6461: 6458: 6455: 6452: 6449: 6446: 6443: 6440: 6437: 6434: 6431: 6428: 6425: 6422: 6419: 6416: 6413: 6410: 6407: 6404: 6401: 6398: 6395: 6392: 6388: 6387: 6383: 6375: 6374: 6366: 6365: 6362: 6359: 6356: 6353: 6350: 6346: 6345: 6342: 6339: 6336: 6333: 6330: 6326: 6325: 6322: 6319: 6316: 6313: 6310: 6306: 6305: 6302: 6299: 6296: 6293: 6290: 6286: 6285: 6282: 6279: 6276: 6273: 6270: 6266: 6265: 6262: 6259: 6256: 6253: 6250: 6246: 6245: 6242: 6239: 6236: 6233: 6230: 6226: 6225: 6222: 6219: 6216: 6213: 6210: 6206: 6205: 6202: 6199: 6196: 6193: 6190: 6186: 6185: 6182: 6179: 6176: 6173: 6170: 6166: 6165: 6162: 6159: 6156: 6153: 6150: 6146: 6145: 6142: 6139: 6136: 6133: 6130: 6126: 6125: 6122: 6119: 6116: 6113: 6110: 6106: 6105: 6102: 6099: 6096: 6093: 6090: 6086: 6085: 6082: 6079: 6076: 6073: 6070: 6069:Chlorpromazine 6066: 6065: 6062: 6059: 6056: 6053: 6050: 6046: 6045: 6042: 6039: 6036: 6033: 6030: 6026: 6025: 6022: 6019: 6016: 6013: 6010: 6006: 6005: 6002: 5999: 5996: 5993: 5990: 5986: 5985: 5977: 5976: 5972: 5971: 5967: 5966: 5963: 5960: 5957: 5946: 5945: 5944: 5941: 5935: 5929: 5923: 5917: 5915:Adverse effect 5908:Acronyms used: 5901: 5892: 5891: 5888: 5885: 5882: 5879: 5876: 5873: 5870: 5867: 5864: 5861: 5859:Zuclopenthixol 5855: 5854: 5851: 5848: 5845: 5842: 5839: 5836: 5833: 5830: 5827: 5811: 5805: 5804: 5801: 5798: 5795: 5777: 5774: 5771: 5768: 5765: 5762: 5746: 5740: 5739: 5736: 5733: 5730: 5727: 5724: 5721: 5718: 5715: 5712: 5696: 5690: 5689: 5686: 5683: 5680: 5677: 5674: 5671: 5668: 5665: 5662: 5659: 5653: 5652: 5645: 5642: 5639: 5636: 5633: 5630: 5627: 5624: 5621: 5605: 5599: 5598: 5595: 5592: 5589: 5586: 5583: 5580: 5577: 5574: 5571: 5555: 5549: 5548: 5545: 5542: 5539: 5521: 5518: 5515: 5512: 5509: 5506: 5490: 5484: 5483: 5480: 5477: 5474: 5456: 5453: 5450: 5447: 5442: 5439: 5423: 5417: 5416: 5409: 5406: 5403: 5400: 5397: 5394: 5391: 5388: 5385: 5382: 5376: 5375: 5364: 5359: 5356: 5353: 5335: 5332: 5329: 5326: 5323: 5320: 5304: 5298: 5297: 5290: 5287: 5284: 5281: 5278: 5275: 5272: 5269: 5266: 5263: 5257: 5256: 5253: 5250: 5247: 5244: 5241: 5238: 5235: 5232: 5229: 5226: 5220: 5219: 5212: 5209: 5206: 5203: 5200: 5197: 5194: 5191: 5188: 5172: 5166: 5165: 5162: 5159: 5156: 5153: 5150: 5147: 5144: 5141: 5138: 5122: 5116: 5115: 5112: 5109: 5106: 5103: 5100: 5097: 5094: 5091: 5088: 5085: 5079: 5078: 5075: 5072: 5069: 5066: 5063: 5060: 5057: 5054: 5051: 5048: 5042: 5041: 5038: 5035: 5032: 5029: 5026: 5023: 5020: 5017: 5014: 4998: 4992: 4991: 4988: 4985: 4982: 4964: 4961: 4958: 4953: 4950: 4947: 4931: 4925: 4924: 4921: 4918: 4915: 4897: 4894: 4891: 4888: 4885: 4882: 4866: 4860: 4859: 4856: 4853: 4850: 4847: 4844: 4841: 4838: 4835: 4832: 4829: 4823: 4822: 4814: 4811: 4808: 4805: 4802: 4799: 4796: 4793: 4790: 4787: 4781: 4780: 4774: 4769: 4766: 4763: 4745: 4742: 4739: 4736: 4733: 4730: 4714: 4708: 4707: 4704: 4701: 4698: 4695: 4692: 4689: 4686: 4683: 4680: 4664: 4658: 4657: 4654: 4651: 4648: 4645: 4642: 4639: 4636: 4633: 4630: 4627: 4621: 4620: 4617: 4614: 4611: 4593: 4590: 4587: 4584: 4581: 4578: 4562: 4556: 4555: 4548: 4545: 4542: 4524: 4521: 4518: 4515: 4512: 4509: 4493: 4487: 4486: 4479: 4476: 4473: 4470: 4467: 4464: 4461: 4458: 4455: 4439: 4433: 4432: 4429: 4426: 4423: 4420: 4417: 4414: 4411: 4408: 4405: 4402: 4396: 4395: 4392: 4389: 4386: 4383: 4380: 4377: 4374: 4371: 4368: 4365: 4359: 4358: 4339: 4336: 4333: 4330: 4327: 4324: 4321: 4318: 4315: 4299: 4293: 4292: 4285: 4282: 4279: 4276: 4273: 4270: 4267: 4264: 4261: 4245: 4243:Chlorpromazine 4239: 4238: 4235: 4232: 4229: 4226: 4223: 4220: 4217: 4214: 4211: 4208: 4202: 4201: 4198: 4195: 4192: 4174: 4171: 4168: 4165: 4162: 4159: 4143: 4137: 4136: 4130: 4125: 4122: 4117: 4099: 4096: 4093: 4084: 4081: 4078: 4062: 4056: 4055: 4052: 4049: 4046: 4043: 4040: 4037: 4034: 4031: 4028: 4025: 4019: 4018: 4008: 4005: 4002: 3984: 3981: 3978: 3975: 3972: 3969: 3953: 3947: 3946: 3943: 3938: 3933: 3925: 3919: 3914: 3909: 3904: 3898: 3889: 3884: 3883: 3875: 3874: 3871: 3870: 3868: 3865: 3862: 3859: 3856: 3853: 3851:Zuclopenthixol 3847: 3846: 3844: 3841: 3838: 3835: 3832: 3829: 3823: 3822: 3820: 3817: 3814: 3811: 3808: 3805: 3799: 3798: 3796: 3793: 3790: 3787: 3784: 3781: 3775: 3774: 3772: 3769: 3766: 3763: 3760: 3757: 3751: 3750: 3748: 3745: 3742: 3739: 3736: 3733: 3727: 3726: 3724: 3721: 3718: 3715: 3712: 3709: 3703: 3702: 3700: 3697: 3694: 3691: 3688: 3685: 3679: 3678: 3676: 3673: 3670: 3667: 3664: 3661: 3655: 3654: 3652: 3649: 3646: 3643: 3640: 3637: 3631: 3630: 3628: 3625: 3622: 3619: 3616: 3613: 3607: 3606: 3604: 3601: 3598: 3595: 3592: 3589: 3583: 3582: 3580: 3577: 3574: 3571: 3568: 3565: 3559: 3558: 3556: 3553: 3550: 3547: 3544: 3541: 3535: 3534: 3532: 3529: 3526: 3523: 3520: 3517: 3511: 3510: 3508: 3505: 3502: 3499: 3496: 3493: 3487: 3486: 3484: 3481: 3478: 3475: 3472: 3469: 3463: 3462: 3460: 3457: 3454: 3451: 3448: 3445: 3439: 3438: 3436: 3433: 3430: 3427: 3424: 3421: 3415: 3414: 3412: 3409: 3406: 3403: 3400: 3397: 3391: 3390: 3388: 3385: 3382: 3379: 3376: 3373: 3367: 3366: 3364: 3361: 3358: 3355: 3352: 3349: 3343: 3342: 3340: 3337: 3334: 3331: 3328: 3325: 3319: 3318: 3316: 3313: 3310: 3307: 3304: 3301: 3295: 3294: 3292: 3289: 3286: 3283: 3280: 3277: 3271: 3270: 3268: 3265: 3262: 3259: 3256: 3253: 3247: 3246: 3244: 3241: 3238: 3235: 3232: 3229: 3223: 3222: 3220: 3217: 3214: 3211: 3208: 3205: 3199: 3198: 3196: 3193: 3190: 3187: 3184: 3181: 3175: 3174: 3172: 3169: 3166: 3163: 3160: 3157: 3151: 3150: 3148: 3145: 3142: 3139: 3136: 3133: 3127: 3126: 3124: 3121: 3118: 3115: 3112: 3109: 3103: 3102: 3100: 3097: 3094: 3091: 3088: 3085: 3079: 3078: 3076: 3073: 3070: 3067: 3064: 3061: 3055: 3054: 3052: 3049: 3046: 3043: 3040: 3037: 3031: 3030: 3028: 3025: 3022: 3019: 3016: 3013: 3007: 3006: 3004: 3001: 2998: 2995: 2992: 2989: 2983: 2982: 2980: 2977: 2974: 2971: 2968: 2965: 2959: 2958: 2956: 2953: 2950: 2947: 2944: 2941: 2935: 2934: 2932: 2929: 2926: 2923: 2920: 2917: 2911: 2910: 2908: 2905: 2902: 2899: 2896: 2893: 2887: 2886: 2884: 2881: 2878: 2875: 2872: 2869: 2863: 2862: 2860: 2857: 2854: 2851: 2848: 2845: 2839: 2838: 2836: 2833: 2830: 2827: 2824: 2821: 2815: 2814: 2812: 2809: 2806: 2803: 2800: 2797: 2791: 2790: 2788: 2785: 2782: 2779: 2776: 2773: 2767: 2766: 2764: 2761: 2758: 2755: 2752: 2749: 2743: 2742: 2740: 2737: 2734: 2731: 2728: 2725: 2719: 2718: 2716: 2713: 2710: 2707: 2704: 2701: 2695: 2694: 2692: 2689: 2686: 2683: 2680: 2677: 2671: 2670: 2668: 2665: 2662: 2659: 2656: 2653: 2647: 2646: 2644: 2641: 2638: 2635: 2632: 2629: 2623: 2622: 2620: 2617: 2614: 2611: 2608: 2605: 2603:Chlorpromazine 2599: 2598: 2596: 2593: 2590: 2587: 2584: 2581: 2575: 2574: 2572: 2569: 2566: 2563: 2560: 2557: 2551: 2550: 2548: 2545: 2542: 2539: 2536: 2533: 2527: 2526: 2524: 2521: 2518: 2515: 2512: 2509: 2503: 2502: 2500: 2497: 2494: 2491: 2488: 2485: 2479: 2478: 2476: 2473: 2470: 2467: 2464: 2461: 2455: 2454: 2452: 2449: 2446: 2443: 2440: 2437: 2431: 2430: 2428: 2425: 2422: 2419: 2416: 2413: 2407: 2406: 2404: 2401: 2398: 2395: 2392: 2389: 2383: 2382: 2380: 2377: 2374: 2371: 2368: 2365: 2359: 2358: 2355: 2352: 2349: 2346: 2343: 2340: 2332: 2331: 2324: 2321: 2316: 2312: 2308: 2300: 2289: 2284: 2277: 2271: 2258:chlorpromazine 2244: 2221: 2217: 2207: 2183: 2177:tend to block 2175:chlorpromazine 2166: 2163: 2162: 2161: 2157: 2153: 2147: 2143: 2139: 2135: 2129: 2125: 2119: 2113: 2109: 2101: 2098: 2097: 2096: 2091: 2087: 2079: 2076: 2069: 2065: 2054: 2048: 2045: 2044: 2043: 2029: 2021: 2015: 2007: 2004: 2003: 2002: 1999:dibenzothiepin 1992: 1969: 1943: 1929: 1921: 1918: 1917: 1916: 1910: 1902: 1901:Butyrophenones 1899: 1898: 1897: 1891: 1877: 1863: 1857: 1851: 1831: 1828: 1827: 1826: 1820: 1816: 1798: 1792: 1789:social phobias 1777:antidepressant 1768: 1765: 1760:Main article: 1757: 1754: 1753: 1752: 1745: 1742: 1741: 1740: 1735: 1730: 1725: 1720: 1715: 1708: 1705: 1704: 1703: 1698: 1693: 1686: 1683: 1678: 1675: 1674: 1673: 1671:Zuclopenthixol 1668: 1663: 1658: 1653: 1643:Main article: 1640: 1637: 1636: 1635: 1625: 1620: 1610: 1604: 1599: 1594: 1584: 1579: 1574: 1569: 1564: 1559: 1549: 1544: 1539: 1534: 1529: 1526:Chlorpromazine 1523: 1514:Phenothiazines 1512:Main article: 1509: 1508:Phenothiazines 1506: 1505: 1504: 1499: 1493: 1485: 1482: 1481: 1480: 1475: 1465: 1455: 1449: 1444: 1439: 1431:Butyrophenones 1429:Main article: 1426: 1425:Butyrophenones 1423: 1418:Main article: 1415: 1412: 1369:Chlorpromazine 1362: 1361:List of agents 1359: 1300: 1297: 1243: 1240: 1239: 1238: 1233: 1228: 1223: 1218: 1212: 1207: 1201: 1196: 1195: 1194: 1187: 1184: 1181: 1178: 1169: 1160: 1157:and serotonin 1153: 1136: 1123: 1122: 1116: 1106: 1105: 1104: 1101: 1098: 1095: 1094:Blurred vision 1089: 1082: 1079: 1078: 1077: 1074: 1071: 1065: 1053: 1052: 1051: 1045: 1039: 1027: 1024: 1021: 1018: 1015: 1012: 998: 995: 986:bowel ischemia 974:cardiomyopathy 897: 894: 812: 809: 754:mood disorders 681: 678: 649: 646: 621: 618: 555:Main article: 552: 549: 516: 513: 507: 504: 474: 471: 465: 462: 426:Main article: 423: 420: 381: 380: 374: 368: 362: 355:antidepressant 348: 338: 335: 267:chlorpromazine 190:hallucinations 166:Antipsychotics 161: 160: 154: 153: 149: 148: 141: 135: 134: 133:External links 130: 129: 122: 116: 115: 111: 110: 84: 80: 79: 76: 70: 69: 65: 64: 54: 46: 45: 37: 36: 26: 9: 6: 4: 3: 2: 27484: 27473: 27470: 27468: 27465: 27463: 27460: 27458: 27455: 27454: 27452: 27437: 27434: 27432: 27429: 27427: 27426:Karl Leonhard 27424: 27422: 27419: 27417: 27414: 27412: 27409: 27408: 27406: 27404: 27400: 27390: 27387: 27385: 27384:Psychotherapy 27382: 27380: 27379:Light therapy 27377: 27375: 27372: 27370: 27367: 27365: 27362: 27360: 27357: 27355: 27352: 27351: 27349: 27345: 27337: 27334: 27332: 27329: 27327: 27324: 27322: 27319: 27318: 27317: 27314: 27312: 27309: 27307: 27304: 27303: 27301: 27299: 27294: 27288: 27285: 27283: 27280: 27278: 27275: 27273: 27270: 27268: 27265: 27263: 27260: 27259: 27257: 27254: 27249: 27245: 27237: 27234: 27232: 27229: 27228: 27227: 27224: 27222: 27221:Oxcarbazepine 27219: 27217: 27214: 27212: 27211:Carbamazepine 27209: 27208: 27206: 27204: 27200: 27197: 27195: 27191: 27185: 27182: 27180: 27177: 27175: 27172: 27170: 27167: 27165: 27162: 27160: 27157: 27155: 27152: 27151: 27149: 27147: 27143: 27137: 27134: 27132: 27129: 27127: 27124: 27122: 27119: 27115: 27112: 27110: 27107: 27106: 27105: 27104: 27100: 27098: 27095: 27093: 27092:Hallucination 27090: 27086: 27083: 27081: 27078: 27076: 27073: 27072: 27071: 27068: 27066: 27063: 27061: 27058: 27057: 27055: 27053: 27049: 27039: 27036: 27035: 27033: 27031:Comorbidities 27029: 27023: 27020: 27018: 27015: 27013: 27010: 27008: 27005: 27003: 27000: 26998: 26995: 26993: 26990: 26989: 26987: 26985: 26981: 26975: 26974:Rapid cycling 26972: 26970: 26967: 26965: 26962: 26960: 26957: 26955: 26952: 26950: 26947: 26945: 26942: 26940: 26937: 26935: 26932: 26931: 26929: 26927: 26923: 26920: 26918: 26914: 26910: 26909:Mood disorder 26903: 26898: 26896: 26891: 26889: 26884: 26883: 26880: 26867: 26866: 26861: 26858: 26857: 26852: 26849: 26848: 26843: 26840: 26839: 26834: 26831: 26830: 26829:Serotonergics 26825: 26822: 26821: 26816: 26813: 26812: 26809: 26804: 26803: 26800: 26790: 26787: 26785: 26782: 26780: 26777: 26775: 26772: 26770: 26767: 26765: 26762: 26760: 26757: 26755: 26752: 26750: 26749:Sonepiprazole 26747: 26745: 26742: 26740: 26737: 26735: 26732: 26730: 26727: 26725: 26722: 26720: 26717: 26715: 26712: 26710: 26707: 26705: 26702: 26700: 26697: 26695: 26692: 26690: 26687: 26685: 26682: 26680: 26677: 26675: 26672: 26670: 26667: 26665: 26664:Iodobenzamide 26662: 26660: 26657: 26655: 26652: 26650: 26647: 26645: 26642: 26640: 26637: 26635: 26632: 26630: 26627: 26625: 26624:Bromocriptine 26622: 26620: 26617: 26615: 26612: 26610: 26607: 26605: 26601: 26598: 26597: 26594: 26591: 26589: 26586: 26584: 26581: 26579: 26576: 26574: 26570: 26567: 26566: 26563: 26560: 26558: 26555: 26553: 26550: 26548: 26545: 26543: 26540: 26538: 26535: 26533: 26530: 26528: 26525: 26523: 26520: 26518: 26515: 26513: 26510: 26508: 26505: 26503: 26500: 26498: 26497:Benzquinamide 26495: 26493: 26490: 26488: 26485: 26483: 26480: 26478: 26474: 26471: 26470: 26467: 26464: 26462: 26459: 26457: 26454: 26452: 26449: 26447: 26444: 26442: 26439: 26437: 26434: 26432: 26429: 26427: 26424: 26422: 26419: 26417: 26414: 26412: 26409: 26407: 26404: 26402: 26399: 26397: 26394: 26392: 26389: 26386: 26382: 26379: 26377: 26374: 26372: 26369: 26367: 26364: 26362: 26359: 26357: 26354: 26352: 26349: 26347: 26344: 26342: 26339: 26337: 26334: 26332: 26329: 26327: 26324: 26322: 26319: 26317: 26316:DHA-clozapine 26314: 26312: 26309: 26307: 26304: 26302: 26299: 26297: 26294: 26292: 26289: 26287: 26284: 26282: 26279: 26277: 26274: 26272: 26269: 26267: 26264: 26262: 26258: 26255: 26254: 26251: 26248: 26246: 26243: 26241: 26240:Trifluperidol 26238: 26236: 26233: 26230: 26226: 26223: 26221: 26218: 26216: 26213: 26211: 26208: 26206: 26203: 26201: 26200:Thiopropazate 26198: 26196: 26193: 26191: 26188: 26186: 26183: 26181: 26180:Sulforidazine 26178: 26176: 26173: 26171: 26168: 26166: 26163: 26161: 26158: 26156: 26153: 26151: 26148: 26146: 26143: 26141: 26138: 26135: 26131: 26128: 26126: 26123: 26121: 26118: 26116: 26113: 26111: 26108: 26106: 26103: 26101: 26098: 26096: 26093: 26091: 26088: 26086: 26083: 26081: 26080:Levosulpiride 26078: 26076: 26073: 26071: 26068: 26066: 26063: 26061: 26058: 26056: 26053: 26051: 26050:Fluprothixene 26048: 26046: 26043: 26040: 26036: 26033: 26031: 26028: 26026: 26023: 26021: 26018: 26016: 26013: 26011: 26008: 26006: 26003: 26001: 25998: 25996: 25993: 25991: 25988: 25986: 25983: 25981: 25978: 25976: 25973: 25971: 25968: 25966: 25963: 25961: 25958: 25956: 25953: 25951: 25948: 25946: 25943: 25941: 25938: 25936: 25932: 25929: 25928: 25926: 25922: 25916: 25913: 25911: 25908: 25906: 25903: 25901: 25898: 25896: 25893: 25891: 25888: 25886: 25883: 25881: 25878: 25876: 25873: 25871: 25868: 25866: 25863: 25861: 25858: 25856: 25853: 25851: 25848: 25846: 25843: 25841: 25838: 25836: 25833: 25831: 25828: 25826: 25825:Phencyclidine 25823: 25821: 25818: 25816: 25813: 25811: 25808: 25806: 25803: 25801: 25798: 25796: 25793: 25791: 25788: 25786: 25783: 25781: 25778: 25776: 25773: 25771: 25768: 25766: 25763: 25761: 25758: 25756: 25753: 25751: 25748: 25746: 25743: 25741: 25738: 25736: 25733: 25731: 25728: 25726: 25723: 25721: 25718: 25716: 25713: 25711: 25708: 25706: 25702: 25699: 25698: 25695: 25692: 25690: 25687: 25685: 25682: 25680: 25677: 25675: 25674:Brilaroxazine 25672: 25670: 25669:Brexpiprazole 25667: 25665: 25662: 25660: 25657: 25654: 25650: 25647: 25645: 25641: 25638: 25637: 25634: 25631: 25629: 25626: 25624: 25618: 25616: 25610: 25608: 25602: 25600: 25597: 25595: 25592: 25590: 25587: 25585: 25581: 25578: 25577: 25574: 25571: 25569: 25566: 25564: 25563:Dihydrexidine 25561: 25559: 25556: 25554: 25550: 25547: 25546: 25543: 25540: 25538: 25535: 25533: 25530: 25528: 25525: 25523: 25520: 25518: 25515: 25513: 25510: 25508: 25505: 25503: 25500: 25498: 25495: 25493: 25492:Bromocriptine 25489: 25486: 25485: 25482: 25479: 25477: 25474: 25472: 25469: 25467: 25464: 25462: 25458: 25455: 25454: 25451: 25448: 25446: 25443: 25441: 25437: 25434: 25433: 25431: 25427: 25424: 25422: 25414: 25404: 25401: 25399: 25396: 25394: 25391: 25389: 25386: 25384: 25381: 25379: 25376: 25374: 25370: 25367: 25366: 25363: 25360: 25358: 25355: 25353: 25350: 25348: 25345: 25343: 25340: 25338: 25335: 25333: 25330: 25327: 25323: 25320: 25318: 25317:Norquetiapine 25315: 25313: 25310: 25308: 25305: 25303: 25300: 25298: 25297:DHA-clozapine 25295: 25293: 25290: 25288: 25285: 25283: 25280: 25278: 25274: 25271: 25270: 25267: 25264: 25261: 25257: 25254: 25252: 25249: 25247: 25244: 25242: 25239: 25236: 25232: 25229: 25227: 25224: 25222: 25219: 25216: 25212: 25209: 25207: 25204: 25202: 25199: 25197: 25193: 25190: 25189: 25187: 25183: 25177: 25174: 25172: 25169: 25167: 25163: 25160: 25159: 25157: 25153: 25147: 25144: 25142: 25139: 25137: 25134: 25132: 25129: 25127: 25124: 25122: 25119: 25117: 25114: 25112: 25109: 25107: 25104: 25102: 25099: 25097: 25094: 25092: 25089: 25087: 25083: 25080: 25079: 25076: 25073: 25071: 25065: 25063: 25057: 25055: 25052: 25050: 25044: 25042: 25039: 25037: 25034: 25032: 25029: 25027: 25024: 25022: 25018: 25015: 25014: 25011: 25008: 25006: 25003: 25001: 24998: 24996: 24995:Dihydrexidine 24993: 24991: 24988: 24986: 24983: 24981: 24977: 24974: 24973: 24970: 24967: 24965: 24962: 24960: 24957: 24955: 24952: 24950: 24947: 24945: 24942: 24940: 24936: 24933: 24932: 24929: 24926: 24924: 24921: 24919: 24916: 24914: 24911: 24909: 24906: 24904: 24901: 24899: 24896: 24894: 24891: 24889: 24885: 24882: 24881: 24879: 24875: 24872: 24870: 24862: 24858: 24855: 24848: 24843: 24841: 24836: 24834: 24829: 24828: 24825: 24813: 24808: 24804: 24802: 24799: 24797: 24794: 24792: 24783: 24782: 24779: 24773: 24770: 24768: 24765: 24763: 24760: 24758: 24755: 24753: 24750: 24749: 24747: 24744: 24740: 24735: 24729: 24726: 24724: 24721: 24720: 24718: 24715: 24711: 24707: 24701: 24694: 24692: 24689: 24687: 24684: 24682: 24681:Decongestants 24679: 24678: 24676: 24673: 24669: 24663: 24657: 24654: 24652: 24649: 24647: 24644: 24642: 24639: 24637: 24634: 24632: 24629: 24627: 24624: 24622: 24619: 24617: 24613: 24610: 24606: 24603: 24601: 24600:Dissociatives 24598: 24596: 24593: 24592: 24591: 24590:Hallucinogens 24588: 24586: 24583: 24581: 24578: 24576: 24573: 24571: 24568: 24566: 24563: 24561: 24558: 24556: 24553: 24551: 24548: 24546: 24543: 24541: 24538: 24536: 24533: 24531: 24528: 24526: 24523: 24521: 24518: 24516: 24513: 24509: 24506: 24504: 24501: 24500: 24499: 24496: 24494: 24491: 24490: 24488: 24485: 24481: 24476: 24472: 24466: 24463: 24461: 24458: 24456: 24453: 24451: 24448: 24444: 24441: 24440: 24439: 24436: 24434: 24431: 24430: 24428: 24425: 24421: 24415: 24411: 24407: 24399: 24396: 24394: 24391: 24390: 24389: 24386: 24385: 24383: 24380: 24374: 24370: 24362: 24359: 24357: 24354: 24352: 24349: 24347: 24344: 24342: 24339: 24338: 24337: 24334: 24333: 24331: 24328: 24322: 24318: 24312: 24309: 24307: 24304: 24300: 24297: 24295: 24294:Anthelmintics 24292: 24290: 24287: 24286: 24285: 24282: 24280: 24277: 24275: 24272: 24269: 24265: 24261: 24258: 24257: 24255: 24252: 24248: 24244: 24240: 24235: 24231: 24225: 24221: 24218: 24216: 24213: 24209: 24206: 24204: 24201: 24200: 24199: 24196: 24194: 24191: 24190: 24188: 24185: 24181: 24175: 24169: 24166: 24164: 24161: 24159: 24156: 24154: 24151: 24150: 24148: 24145: 24141: 24138:genitourinary 24135: 24129: 24126: 24124: 24121: 24119: 24118:Antipruritics 24116: 24114: 24111: 24109: 24106: 24105: 24103: 24100: 24096: 24092: 24084: 24081: 24079: 24076: 24074: 24071: 24070: 24069: 24066: 24062: 24059: 24057: 24054: 24052: 24049: 24048: 24047: 24046: 24042: 24040: 24037: 24035: 24034:Beta blockers 24032: 24030: 24027: 24025: 24022: 24020: 24017: 24013: 24010: 24008: 24005: 24003: 24000: 23999: 23998: 23997: 23992: 23991: 23989: 23986: 23982: 23976: 23968: 23965: 23963: 23960: 23958: 23955: 23954: 23953: 23950: 23946: 23943: 23941: 23938: 23936: 23935:Antiplatelets 23933: 23932: 23931: 23928: 23927: 23925: 23922: 23916: 23912: 23906: 23903: 23901: 23898: 23896: 23893: 23891: 23888: 23886: 23882: 23879: 23877: 23874: 23872: 23869: 23865: 23862: 23860: 23853: 23851: 23848: 23847: 23846: 23843: 23842: 23840: 23837: 23833: 23828: 23824: 23820: 23812: 23807: 23805: 23800: 23798: 23793: 23792: 23789: 23773: 23771: 23768: 23767: 23765: 23762: 23759: 23756: 23754: 23751: 23750: 23746: 23740: 23737: 23734: 23733: 23730: 23729:Tetrabenazine 23727: 23725: 23722: 23720: 23717: 23715: 23711: 23710: 23708: 23704: 23698: 23695: 23693: 23690: 23688: 23685: 23682: 23681: 23678: 23675: 23673: 23670: 23667: 23663: 23660: 23658: 23655: 23653: 23650: 23648: 23644: 23643: 23640: 23637: 23635: 23634:Brexpiprazole 23632: 23630: 23629:Brilaroxazine 23627: 23623: 23620: 23619: 23618: 23615: 23613: 23609: 23605: 23604: 23601: 23598: 23596: 23592: 23591: 23588: 23585: 23583: 23580: 23578: 23575: 23571: 23568: 23567: 23566: 23563: 23561: 23558: 23556: 23553: 23551: 23547: 23546:Benzisoxazole 23543: 23542: 23540: 23538: 23534: 23528: 23525: 23522: 23521: 23518: 23515: 23513: 23510: 23508: 23505: 23503: 23500: 23498: 23495: 23493: 23490: 23488: 23485: 23483: 23479: 23478: 23475: 23472: 23470: 23466: 23465: 23462: 23459: 23457: 23454: 23452: 23449: 23447: 23444: 23442: 23439: 23437: 23434: 23432: 23431:Levosulpiride 23429: 23427: 23424: 23422: 23418: 23417: 23415: 23411: 23403: 23400: 23398: 23395: 23394: 23393: 23390: 23388: 23385: 23381: 23378: 23377: 23376: 23373: 23369: 23366: 23365: 23364: 23361: 23359: 23356: 23354: 23353:Thioxanthenes 23350: 23349: 23346: 23343: 23341: 23338: 23336: 23333: 23331: 23328: 23326: 23325:Thiopropazate 23323: 23321: 23320:Sulforidazine 23318: 23316: 23313: 23311: 23308: 23304: 23301: 23299: 23296: 23295: 23294: 23291: 23289: 23286: 23282: 23279: 23277: 23274: 23272: 23269: 23268: 23267: 23264: 23262: 23259: 23257: 23254: 23252: 23249: 23247: 23244: 23240: 23237: 23235: 23232: 23231: 23230: 23227: 23225: 23222: 23220: 23217: 23215: 23212: 23210: 23207: 23205: 23202: 23200: 23197: 23195: 23192: 23190: 23186: 23185: 23182: 23179: 23177: 23174: 23172: 23169: 23167: 23163: 23162: 23159: 23158:Trifluperidol 23156: 23154: 23151: 23149: 23146: 23144: 23141: 23139: 23136: 23132: 23129: 23128: 23127: 23124: 23122: 23119: 23115: 23112: 23111: 23110: 23107: 23105: 23102: 23100: 23096: 23095: 23093: 23091: 23087: 23082: 23078: 23071: 23066: 23064: 23059: 23057: 23052: 23051: 23048: 23041: 23040:85-903827-1-0 23037: 23033: 23032: 23024: 23021: 23018: 23015: 23012: 23009: 23006: 23003: 23000: 22997: 22994: 22991: 22987: 22984: 22983: 22972: 22968: 22963: 22958: 22954: 22950: 22946: 22942: 22938: 22933: 22932: 22917: 22913: 22909: 22905: 22900: 22895: 22891: 22887: 22883: 22878: 22874: 22870: 22865: 22860: 22856: 22852: 22848: 22843: 22831: 22827: 22826: 22821: 22817: 22813: 22807: 22799: 22795: 22790: 22785: 22781: 22777: 22774:(4): 616–31. 22773: 22769: 22765: 22760: 22759: 22747: 22743: 22742: 22738: 22733: 22729: 22723: 22713: 22709: 22705: 22701: 22696: 22691: 22687: 22683: 22679: 22675: 22671: 22666: 22662: 22658: 22654: 22649: 22645: 22641: 22636: 22631: 22627: 22623: 22619: 22615: 22611: 22606: 22602: 22598: 22594: 22590: 22586: 22582: 22577: 22573: 22567: 22563: 22559: 22555: 22550: 22549: 22537: 22533: 22529: 22528: 22524: 22519: 22515: 22509: 22507: 22505: 22496: 22490: 22482: 22478: 22474: 22470: 22466: 22462: 22455: 22447: 22443: 22436: 22427: 22422: 22418: 22411: 22409: 22407: 22398: 22397: 22392: 22385: 22377: 22373: 22367: 22359: 22352: 22344: 22340: 22334: 22326: 22322: 22315: 22307: 22303: 22299: 22292: 22290: 22288: 22286: 22284: 22275: 22271: 22266: 22261: 22256: 22251: 22248:: 1541–1551. 22247: 22243: 22239: 22232: 22226: 22220: 22214: 22208: 22200: 22196: 22191: 22186: 22181: 22176: 22172: 22168: 22164: 22157: 22141: 22135: 22128: 22124: 22121: 22116: 22108: 22104: 22100: 22096: 22092: 22088: 22081: 22074: 22069: 22067: 22058: 22052: 22048: 22047: 22040: 22032: 22026: 22022: 22021: 22013: 22006: 22005:9781305537231 22002: 21998: 21992: 21984: 21978: 21974: 21970: 21969:"neuroleptic" 21963: 21955: 21949: 21945: 21938: 21930: 21926: 21922: 21918: 21914: 21910: 21906: 21902: 21898: 21891: 21883: 21879: 21873: 21869: 21868: 21860: 21852: 21846: 21842: 21838: 21834: 21827: 21811: 21807: 21801: 21793: 21786: 21770: 21766: 21762: 21758: 21754: 21750: 21746: 21742: 21735: 21733: 21722: 21715:(6): 1071–88. 21714: 21710: 21703: 21695: 21691: 21687: 21683: 21680:(4): 238–46. 21679: 21675: 21668: 21660: 21656: 21652: 21648: 21644: 21640: 21633: 21625: 21621: 21617: 21613: 21605: 21597: 21590: 21582: 21578: 21573: 21568: 21564: 21560: 21557:(4): 325–31. 21556: 21552: 21548: 21541: 21539: 21530: 21526: 21522: 21518: 21511: 21503: 21496: 21494: 21485: 21481: 21477: 21473: 21469: 21465: 21458: 21456: 21447: 21443: 21436: 21427: 21419: 21415: 21411: 21407: 21400: 21392: 21388: 21384: 21380: 21376: 21372: 21369:(5): 385–91. 21368: 21364: 21357: 21349: 21345: 21341: 21337: 21333: 21329: 21326:(7): 509–22. 21325: 21321: 21314: 21306: 21302: 21298: 21294: 21290: 21286: 21283:(4): 769–79. 21282: 21278: 21270: 21262: 21258: 21254: 21250: 21247:(3): 177–93. 21246: 21242: 21235: 21227: 21223: 21219: 21215: 21211: 21207: 21203: 21199: 21192: 21184: 21180: 21176: 21172: 21168: 21164: 21161:(2): 134–41. 21160: 21156: 21148: 21140: 21137:. Datapharm. 21136: 21132: 21126: 21118: 21114: 21113: 21108: 21102: 21094: 21090: 21086: 21085: 21080: 21074: 21066: 21062: 21058: 21057: 21052: 21046: 21038: 21034: 21029: 21024: 21019: 21014: 21010: 21006: 21002: 20995: 20987: 20983: 20979: 20975: 20971: 20967: 20964:(1): 171–81. 20963: 20959: 20951: 20943: 20939: 20935: 20931: 20927: 20923: 20915: 20913: 20904: 20900: 20896: 20892: 20888: 20884: 20880: 20876: 20869: 20853: 20849: 20845: 20837: 20831: 20823: 20819: 20815: 20811: 20807: 20803: 20800:(9): 731–41. 20799: 20795: 20788: 20782: 20777: 20769: 20765: 20760: 20755: 20750: 20745: 20742:: 2901–2905. 20741: 20737: 20733: 20726: 20718: 20714: 20709: 20704: 20699: 20694: 20690: 20686: 20682: 20675: 20667: 20663: 20659: 20655: 20651: 20644: 20636: 20632: 20627: 20622: 20618: 20614: 20610: 20606: 20598: 20590: 20586: 20582: 20578: 20574: 20570: 20566: 20562: 20555: 20547: 20543: 20538: 20533: 20528: 20523: 20519: 20515: 20511: 20504: 20496: 20492: 20487: 20482: 20477: 20472: 20468: 20464: 20460: 20453: 20445: 20441: 20437: 20433: 20429: 20425: 20421: 20417: 20409: 20393: 20389: 20383: 20375: 20371: 20366: 20361: 20357: 20353: 20349: 20345: 20341: 20334: 20326: 20322: 20318: 20314: 20310: 20306: 20302: 20298: 20291: 20283: 20279: 20274: 20269: 20265: 20261: 20257: 20253: 20249: 20242: 20234: 20230: 20225: 20220: 20216: 20212: 20208: 20204: 20197: 20189: 20185: 20181: 20177: 20173: 20166: 20158: 20154: 20149: 20144: 20140: 20136: 20132: 20128: 20124: 20117: 20101: 20097: 20096:"Perospirone" 20090: 20088: 20079: 20075: 20071: 20067: 20063: 20059: 20055: 20051: 20044: 20036: 20032: 20027: 20022: 20018: 20014: 20010: 20006: 19999: 19983: 19982: 19974: 19972: 19963: 19959: 19954: 19949: 19944: 19939: 19935: 19931: 19927: 19920: 19912: 19908: 19904: 19900: 19896: 19892: 19888: 19884: 19876: 19868: 19864: 19859: 19854: 19850: 19846: 19842: 19838: 19834: 19827: 19819: 19815: 19810: 19805: 19801: 19797: 19793: 19789: 19785: 19778: 19762: 19758: 19752: 19744: 19740: 19735: 19730: 19725: 19720: 19716: 19712: 19708: 19701: 19699: 19690: 19686: 19682: 19678: 19674: 19670: 19666: 19662: 19655: 19653: 19651: 19642: 19638: 19634: 19630: 19626: 19622: 19618: 19614: 19607: 19599: 19593: 19589: 19582: 19574: 19568: 19564: 19557: 19549: 19543: 19539: 19538: 19530: 19522: 19516: 19512: 19511: 19503: 19495: 19489: 19485: 19484: 19476: 19468: 19462: 19458: 19457: 19449: 19433: 19429: 19425: 19419: 19411: 19407: 19406:"Perospirone" 19401: 19393: 19389: 19384: 19379: 19375: 19371: 19367: 19363: 19356: 19348: 19344: 19339: 19334: 19330: 19326: 19322: 19318: 19311: 19303: 19299: 19295: 19291: 19287: 19283: 19280:(2): 219–24. 19279: 19275: 19268: 19260: 19254: 19250: 19249: 19241: 19239: 19222: 19218: 19214: 19208: 19200: 19196: 19190: 19182: 19178: 19177:"Nemonapride" 19172: 19156: 19152: 19148: 19142: 19134: 19130: 19126: 19122: 19115: 19107: 19101: 19097: 19096: 19088: 19086: 19069: 19065: 19061: 19055: 19047: 19043: 19039: 19035: 19031: 19027: 19023: 19019: 19012: 19010: 19001: 18995: 18991: 18990: 18982: 18974: 18970: 18965: 18960: 18956: 18952: 18949:(3): 219–29. 18948: 18944: 18940: 18933: 18925: 18921: 18917: 18913: 18909: 18905: 18901: 18897: 18890: 18882: 18878: 18872: 18868: 18867: 18860: 18858: 18849: 18845: 18842:(17): 404–5. 18841: 18837: 18830: 18822: 18818: 18814: 18810: 18806: 18802: 18795: 18787: 18781: 18777: 18776: 18768: 18766: 18757: 18751: 18747: 18746: 18738: 18730: 18724: 18720: 18719: 18711: 18709: 18692: 18688: 18684: 18678: 18662: 18658: 18654: 18648: 18640: 18636: 18630: 18622: 18618: 18612: 18604: 18600: 18594: 18586: 18582: 18578: 18574: 18570: 18566: 18559: 18557: 18555: 18553: 18551: 18549: 18547: 18545: 18543: 18541: 18539: 18537: 18535: 18533: 18531: 18529: 18527: 18525: 18523: 18521: 18519: 18517: 18515: 18513: 18511: 18502: 18496: 18492: 18491: 18483: 18481: 18479: 18470: 18464: 18460: 18459: 18451: 18443: 18439: 18433: 18429: 18428: 18420: 18418: 18416: 18414: 18412: 18410: 18408: 18406: 18404: 18402: 18400: 18398: 18396: 18394: 18392: 18390: 18388: 18386: 18384: 18382: 18380: 18378: 18376: 18374: 18372: 18370: 18368: 18366: 18364: 18362: 18360: 18358: 18356: 18354: 18352: 18350: 18348: 18346: 18344: 18342: 18340: 18338: 18336: 18334: 18332: 18330: 18321: 18317: 18312: 18307: 18302: 18297: 18293: 18289: 18285: 18278: 18270: 18266: 18261: 18256: 18251: 18246: 18242: 18238: 18234: 18227: 18219: 18215: 18210: 18205: 18201: 18197: 18193: 18189: 18185: 18178: 18170: 18166: 18162: 18156: 18152: 18148: 18144: 18137: 18126: 18122: 18118: 18111: 18104: 18102: 18093: 18089: 18084: 18079: 18075: 18071: 18067: 18060: 18052: 18048: 18044: 18040: 18036: 18032: 18031:Life Sciences 18025: 18017: 18013: 18009: 18005: 18001: 17997: 17990: 17988: 17979: 17975: 17971: 17967: 17963: 17959: 17955: 17951: 17944: 17936: 17932: 17928: 17922: 17918: 17914: 17910: 17906: 17899: 17891: 17887: 17883: 17879: 17875: 17871: 17864: 17849: 17845: 17839: 17831: 17827: 17823: 17819: 17815: 17811: 17807: 17803: 17799: 17792: 17784: 17780: 17776: 17772: 17768: 17764: 17760: 17756: 17755:CNS Spectrums 17749: 17741: 17737: 17733: 17729: 17725: 17721: 17717: 17713: 17706: 17704: 17695: 17691: 17687: 17683: 17679: 17672: 17656: 17650: 17643: 17639: 17632: 17624: 17620: 17616: 17612: 17605: 17597: 17593: 17589: 17585: 17578: 17570: 17566: 17562: 17558: 17554: 17550: 17546: 17542: 17535: 17527: 17521: 17517: 17516: 17508: 17500: 17496: 17492: 17488: 17484: 17480: 17476: 17472: 17465: 17463: 17454: 17448: 17444: 17443: 17435: 17433: 17431: 17429: 17427: 17419: 17415: 17409: 17405: 17398: 17390: 17386: 17381: 17376: 17372: 17368: 17364: 17360: 17356: 17349: 17341: 17337: 17332: 17327: 17323: 17319: 17316:(1): 89–101. 17315: 17311: 17307: 17300: 17292: 17288: 17283: 17278: 17273: 17268: 17264: 17260: 17256: 17249: 17241: 17237: 17232: 17227: 17223: 17219: 17215: 17211: 17207: 17200: 17192: 17188: 17183: 17178: 17173: 17168: 17164: 17160: 17156: 17149: 17141: 17137: 17133: 17129: 17124: 17119: 17116:(3): 547–58. 17115: 17111: 17104: 17096: 17092: 17087: 17082: 17078: 17074: 17070: 17066: 17062: 17055: 17047: 17043: 17039: 17035: 17030: 17025: 17021: 17017: 17013: 17006: 16998: 16994: 16989: 16984: 16980: 16976: 16972: 16965: 16957: 16953: 16948: 16943: 16939: 16935: 16931: 16927: 16923: 16916: 16908: 16904: 16899: 16894: 16890: 16886: 16882: 16878: 16874: 16867: 16859: 16855: 16850: 16845: 16841: 16837: 16833: 16826: 16818: 16814: 16810: 16806: 16802: 16798: 16795:(4): 248–57. 16794: 16790: 16783: 16775: 16770: 16765: 16762:(2): 92–100. 16761: 16757: 16753: 16746: 16738: 16732: 16724: 16720: 16715: 16710: 16706: 16702: 16699:(4): 616–31. 16698: 16694: 16690: 16683: 16675: 16671: 16666: 16661: 16657: 16653: 16649: 16642: 16634: 16630: 16626: 16622: 16618: 16614: 16610: 16606: 16599: 16591: 16587: 16583: 16579: 16575: 16571: 16567: 16563: 16559: 16552: 16544: 16540: 16535: 16530: 16525: 16520: 16516: 16512: 16509:(3): e33548. 16508: 16504: 16500: 16493: 16485: 16479: 16475: 16474: 16466: 16464: 16462: 16453: 16449: 16445: 16441: 16437: 16433: 16429: 16425: 16421: 16414: 16406: 16402: 16398: 16394: 16390: 16386: 16383:(7): 841–52. 16382: 16378: 16374: 16367: 16359: 16355: 16349: 16341: 16337: 16332: 16327: 16323: 16319: 16315: 16308: 16300: 16296: 16291: 16286: 16281: 16276: 16272: 16268: 16264: 16257: 16249: 16245: 16240: 16235: 16231: 16227: 16224:(3): 377–82. 16223: 16219: 16215: 16208: 16200: 16196: 16193:(5): 617–22. 16192: 16188: 16181: 16173: 16169: 16165: 16161: 16157: 16153: 16149: 16145: 16138: 16130: 16126: 16121: 16116: 16112: 16108: 16104: 16100: 16096: 16089: 16081: 16077: 16073: 16069: 16065: 16061: 16057: 16053: 16046: 16038: 16034: 16030: 16026: 16022: 16018: 16011: 16003: 15999: 15995: 15991: 15987: 15983: 15979: 15975: 15967: 15959: 15955: 15951: 15947: 15943: 15939: 15935: 15931: 15924: 15922: 15913: 15909: 15905: 15901: 15897: 15893: 15889: 15885: 15878: 15870: 15866: 15861: 15856: 15852: 15848: 15844: 15840: 15836: 15829: 15821: 15817: 15812: 15807: 15803: 15799: 15795: 15791: 15787: 15780: 15778: 15769: 15765: 15759: 15755: 15754: 15746: 15738: 15734: 15729: 15724: 15720: 15716: 15712: 15708: 15704: 15697: 15689: 15685: 15681: 15677: 15673: 15669: 15662: 15654: 15650: 15646: 15642: 15638: 15634: 15630: 15626: 15619: 15611: 15607: 15602: 15597: 15593: 15589: 15588:BMJ Clin Evid 15585: 15578: 15576: 15565: 15561: 15557: 15553: 15550:(3): 313–27. 15549: 15545: 15540: 15528: 15524: 15523: 15518: 15514: 15510: 15506: 15500: 15496: 15492: 15488: 15484: 15483: 15471: 15467: 15463: 15462: 15458: 15453: 15449: 15443: 15441: 15439: 15430: 15426: 15422: 15418: 15414: 15410: 15406: 15402: 15395: 15387: 15383: 15379: 15375: 15371: 15367: 15363: 15359: 15352: 15344: 15340: 15336: 15332: 15328: 15324: 15320: 15316: 15308: 15299: 15294: 15290: 15286: 15282: 15275: 15267: 15263: 15259: 15255: 15251: 15247: 15240: 15232: 15228: 15224: 15220: 15216: 15212: 15208: 15204: 15197: 15189: 15185: 15180: 15175: 15171: 15167: 15163: 15159: 15155: 15151: 15147: 15140: 15132: 15128: 15124: 15120: 15115: 15110: 15106: 15102: 15098: 15091: 15083: 15079: 15075: 15071: 15067: 15063: 15060:(2): 185–94. 15059: 15055: 15047: 15039: 15035: 15030: 15025: 15021: 15017: 15013: 15009: 15005: 14998: 14990: 14986: 14982: 14978: 14974: 14970: 14967:(4): 409–18. 14966: 14962: 14955: 14947: 14943: 14938: 14933: 14929: 14925: 14921: 14914: 14906: 14902: 14897: 14892: 14888: 14884: 14880: 14873: 14865: 14861: 14856: 14851: 14847: 14843: 14840:(3): 345–57. 14839: 14835: 14831: 14824: 14816: 14812: 14807: 14802: 14798: 14794: 14790: 14783: 14775: 14771: 14767: 14763: 14759: 14755: 14751: 14747: 14739: 14731: 14727: 14723: 14719: 14715: 14711: 14708:(7): 633–43. 14707: 14703: 14696: 14688: 14684: 14680: 14676: 14671: 14666: 14662: 14658: 14654: 14647: 14639: 14635: 14631: 14627: 14623: 14622:NIHR Evidence 14619: 14613: 14604: 14595: 14590: 14586: 14582: 14578: 14571: 14555: 14551: 14547: 14541: 14533: 14529: 14525: 14521: 14517: 14513: 14509: 14505: 14498: 14490: 14486: 14481: 14476: 14473:(3): 133–43. 14472: 14468: 14464: 14457: 14449: 14445: 14441: 14437: 14433: 14429: 14426:(8): 600–20. 14425: 14421: 14414: 14406: 14402: 14397: 14392: 14388: 14384: 14380: 14376: 14372: 14365: 14357: 14353: 14349: 14345: 14341: 14340:NIHR Evidence 14337: 14331: 14316: 14310: 14306: 14305: 14297: 14289: 14285: 14281: 14277: 14272: 14271:11380/1288245 14267: 14262: 14257: 14253: 14249: 14245: 14238: 14230: 14226: 14222: 14218: 14213: 14208: 14204: 14200: 14196: 14189: 14181: 14177: 14172: 14167: 14163: 14159: 14155: 14151: 14147: 14140: 14132: 14128: 14124: 14120: 14116: 14112: 14108: 14104: 14097: 14089: 14085: 14081: 14074: 14072: 14063: 14059: 14054: 14049: 14044: 14039: 14035: 14031: 14027: 14020: 14018: 14009: 14005: 14001: 13997: 13993: 13989: 13985: 13981: 13977: 13970: 13962: 13958: 13953: 13948: 13944: 13940: 13935: 13930: 13926: 13922: 13918: 13911: 13903: 13899: 13895: 13891: 13886: 13881: 13877: 13873: 13869: 13865: 13861: 13854: 13846: 13842: 13838: 13834: 13829: 13824: 13820: 13816: 13812: 13805: 13786: 13782: 13775: 13769: 13760: 13752: 13748: 13743: 13738: 13733: 13728: 13724: 13720: 13719:PLOS Medicine 13716: 13709: 13701: 13697: 13693: 13689: 13685: 13678: 13676: 13667: 13663: 13658: 13653: 13649: 13645: 13641: 13637: 13633: 13626: 13618: 13614: 13609: 13604: 13600: 13596: 13592: 13588: 13581: 13564: 13560: 13559: 13555: 13550: 13546: 13540: 13532: 13528: 13523: 13518: 13515:(11): 14–17. 13514: 13510: 13506: 13499: 13497: 13495: 13493: 13477: 13473: 13469: 13465: 13458: 13450: 13446: 13442: 13438: 13431: 13423: 13419: 13415: 13411: 13407: 13403: 13399: 13392: 13384: 13380: 13376: 13372: 13368: 13364: 13356: 13348: 13344: 13339: 13334: 13329: 13324: 13320: 13316: 13312: 13305: 13297: 13293: 13289: 13285: 13281: 13277: 13273: 13269: 13261: 13253: 13249: 13244: 13239: 13234: 13229: 13225: 13221: 13217: 13210: 13202: 13198: 13194: 13190: 13186: 13182: 13175: 13159: 13155: 13151: 13144: 13136: 13132: 13128: 13124: 13119: 13114: 13110: 13106: 13102: 13095: 13080: 13076: 13070: 13062: 13058: 13054: 13050: 13047:(2): 116–41. 13046: 13042: 13034: 13026: 13020: 13016: 13009: 13007: 12998: 12994: 12989: 12984: 12980: 12976: 12972: 12965: 12957: 12951: 12943: 12939: 12934: 12929: 12925: 12921: 12917: 12913: 12909: 12902: 12900: 12891: 12887: 12883: 12879: 12875: 12871: 12867: 12863: 12856: 12848: 12844: 12839: 12834: 12830: 12826: 12822: 12815: 12813: 12804: 12800: 12796: 12792: 12787: 12782: 12778: 12774: 12770: 12766: 12762: 12755: 12753: 12744: 12740: 12736: 12732: 12728: 12724: 12720: 12716: 12709: 12701: 12697: 12693: 12689: 12685: 12681: 12677: 12673: 12665: 12663: 12661: 12659: 12657: 12655: 12653: 12651: 12649: 12640: 12636: 12631: 12626: 12623:(4): 429–47. 12622: 12618: 12614: 12607: 12599: 12595: 12590: 12585: 12581: 12577: 12573: 12569: 12565: 12558: 12550: 12546: 12541: 12536: 12532: 12528: 12524: 12520: 12516: 12509: 12501: 12497: 12492: 12487: 12483: 12479: 12475: 12468: 12466: 12457: 12453: 12448: 12443: 12439: 12435: 12431: 12427: 12423: 12416: 12400: 12396: 12390: 12382: 12378: 12373: 12368: 12365:(2): 201–22. 12364: 12360: 12356: 12349: 12341: 12337: 12332: 12327: 12323: 12319: 12315: 12308: 12300: 12296: 12291: 12286: 12282: 12278: 12274: 12267: 12265: 12256: 12252: 12247: 12242: 12238: 12234: 12230: 12223: 12215: 12211: 12207: 12203: 12199: 12195: 12191: 12187: 12180: 12178: 12176: 12174: 12172: 12170: 12168: 12159: 12155: 12149: 12141: 12137: 12131: 12129: 12127: 12125: 12116: 12112: 12108: 12104: 12100: 12096: 12092: 12088: 12081: 12073: 12069: 12064: 12059: 12055: 12051: 12047: 12043: 12039: 12032: 12024: 12020: 12016: 12012: 12008: 12004: 12000: 11996: 11989: 11973: 11969: 11965: 11959: 11957: 11955: 11946: 11940: 11936: 11929: 11927: 11925: 11923: 11921: 11919: 11910: 11906: 11902: 11898: 11894: 11890: 11882: 11874: 11870: 11866: 11862: 11858: 11854: 11850: 11846: 11839: 11837: 11835: 11833: 11831: 11822: 11818: 11813: 11808: 11804: 11800: 11796: 11789: 11787: 11785: 11783: 11781: 11779: 11777: 11775: 11766: 11762: 11757: 11752: 11748: 11744: 11740: 11736: 11732: 11725: 11723: 11714: 11710: 11706: 11702: 11698: 11694: 11690: 11686: 11679: 11671: 11667: 11663: 11659: 11656:(6): 407–14. 11655: 11651: 11644: 11635: 11626: 11619: 11615: 11609: 11601: 11597: 11592: 11587: 11583: 11579: 11575: 11571: 11567: 11560: 11558: 11549: 11545: 11541: 11537: 11533: 11529: 11525: 11521: 11514: 11512: 11503: 11499: 11494: 11489: 11485: 11481: 11477: 11473: 11469: 11462: 11460: 11451: 11447: 11443: 11439: 11435: 11431: 11427: 11423: 11416: 11409: 11405: 11401: 11396: 11391: 11388:(1): 169–79. 11387: 11383: 11379: 11372: 11364: 11360: 11356: 11352: 11348: 11344: 11340: 11336: 11328: 11326: 11324: 11322: 11320: 11318: 11316: 11314: 11312: 11303: 11299: 11296:(11): 625–9. 11295: 11291: 11290:Dis Nerv Syst 11287: 11280: 11272: 11268: 11262: 11258: 11257: 11249: 11247: 11242: 11227: 11223: 11213: 11210: 11208: 11205: 11204: 11198: 11196: 11192: 11181: 11179: 11174: 11172: 11168: 11163: 11158: 11156: 11152: 11148: 11144: 11140: 11136: 11132: 11127: 11122: 11120: 11116: 11112: 11108: 11102: 11100: 11091: 11089: 11085: 11081: 11077: 11076:paradoxically 11073: 11069: 11063: 11053: 11051: 11047: 11043: 11039: 11038:ventrogluteal 11035: 11025: 11023: 11019: 11009: 11000: 10998: 10992: 10983: 10981: 10976: 10974: 10970: 10969:Antipsychotic 10966: 10965:antipsychotic 10962: 10958: 10954: 10939: 10937: 10933: 10929: 10924: 10922: 10918: 10914: 10910: 10906: 10902: 10898: 10897: 10892: 10888: 10884: 10880: 10876: 10872: 10868: 10862: 10856: 10852: 10848: 10844: 10840: 10836: 10830: 10827: 10823: 10819: 10818:Henri Laborit 10815: 10811: 10806: 10804: 10800: 10796: 10792: 10788: 10780: 10775: 10767: 10753: 10750: 10746: 10742: 10738: 10734: 10730: 10729:vegetable oil 10727: 10723: 10720: 10716: 10712: 10708: 10704: 10700: 10697: 10694: 10691: 10688: 10686:4–9 days 10685: 10682: 10680: 10677: 10675: 10672: 10669: 10667: 10664: 10663: 10660: 10657: 10652:1–2 days 10651: 10648: 10646: 10643: 10641: 10638: 10635: 10633: 10630: 10629: 10626: 10623: 10621:3–6 days 10620: 10617: 10614: 10611: 10609: 10606: 10604: 10601: 10598: 10596: 10593: 10592: 10589: 10586: 10583: 10580: 10577: 10574: 10572: 10569: 10567: 10564: 10561: 10559: 10556: 10555: 10552: 10549: 10546: 10543: 10540: 10537: 10535: 10532: 10530: 10527: 10524: 10522: 10519: 10518: 10515: 10512: 10510:4–7 days 10509: 10506: 10504:2–3 days 10503: 10500: 10498: 10495: 10493: 10490: 10487: 10485: 10482: 10481: 10478: 10475: 10472: 10469: 10466: 10463: 10461: 10458: 10456: 10453: 10450: 10448: 10445: 10444: 10441: 10438: 10435: 10432: 10429: 10426: 10424: 10421: 10419: 10416: 10413: 10411: 10408: 10407: 10404: 10401: 10398: 10395: 10392: 10389: 10386: 10384: 10381: 10378: 10376: 10373: 10372: 10369: 10366: 10363: 10360: 10357: 10354: 10352: 10349: 10347: 10344: 10341: 10339: 10336: 10335: 10332: 10329: 10324:3–9 days 10323: 10320: 10318: 10315: 10313: 10310: 10307: 10305: 10302: 10301: 10298: 10295: 10292: 10289: 10287:1–8 days 10286: 10283: 10281: 10278: 10276: 10273: 10270: 10268: 10265: 10264: 10261: 10258: 10255: 10252: 10250:2–3 days 10249: 10246: 10244: 10241: 10239: 10236: 10233: 10231: 10228: 10227: 10224: 10221: 10218: 10215: 10213:1–2 days 10212: 10209: 10207: 10204: 10202: 10199: 10196: 10194: 10191: 10190: 10187: 10184: 10181: 10178: 10175: 10172: 10170: 10167: 10165: 10162: 10159: 10157: 10154: 10153: 10150: 10147: 10144: 10141: 10139:4–7 days 10138: 10135: 10133: 10130: 10128: 10125: 10122: 10120: 10117: 10116: 10113: 10110: 10107: 10104: 10102:3–9 days 10101: 10098: 10096: 10093: 10091: 10088: 10085: 10083: 10080: 10079: 10076: 10073: 10070: 10067: 10064: 10061: 10059: 10056: 10054: 10051: 10048: 10046: 10043: 10042: 10039: 10036: 10033: 10030: 10027: 10024: 10022: 10019: 10017: 10014: 10011: 10009: 10006: 10005: 10001: 9998: 9991: 9984: 9978: 9975: 9972: 9969: 9966: 9963: 9962: 9953: 9948: 9946: 9941: 9939: 9934: 9933: 9920: 9918: 9915: 9912: 9909: 9906: 9903: 9900: 9897: 9894: 9891: 9889: 9886: 9885: 9881: 9879: 9875: 9872: 9869: 9866: 9863: 9860: 9857: 9854: 9851: 9848: 9846: 9843: 9842: 9838: 9836: 9832: 9829: 9826: 9823: 9821:1.5 L/kg 9820: 9817: 9814: 9811: 9808: 9805: 9803: 9800: 9799: 9795: 9792: 9789: 9786: 9783: 9780: 9777: 9774: 9771: 9768: 9766: 9763: 9762: 9758: 9756: 9753: 9750: 9747: 9744: 9741: 9738: 9735: 9732: 9729: 9727: 9724: 9723: 9719: 9717: 9714: 9711: 9708: 9705: 9702: 9699: 9696: 9693: 9690: 9688: 9685: 9684: 9680: 9677: 9674: 9672:Urine, faeces 9671: 9666: 9663: 9660: 9657: 9654: 9651: 9649: 9646: 9645: 9641: 9639: 9636: 9633: 9630: 9627: 9624: 9621: 9618: 9615: 9612: 9610: 9607: 9606: 9603: 9600: 9598: 9595: 9592: 9589: 9587:1–2 L/kg 9586: 9583: 9580: 9577: 9574: 9571: 9569: 9566: 9565: 9561: 9553: 9549: 9547: 9544: 9541: 9538: 9535: 9532: 9529: 9526: 9523: 9520: 9518: 9515: 9514: 9510: 9507: 9504: 9501: 9499:12.9–17.7 L/h 9498: 9495: 9492: 9489: 9486: 9483: 9481: 9478: 9477: 9473: 9471: 9467: 9464: 9461: 9458: 9455: 9452: 9449: 9446: 9443: 9440: 9438: 9435: 9434: 9430: 9428: 9425: 9422: 9420:Urine, faeces 9419: 9416: 9413: 9410: 9407: 9404: 9401: 9399: 9396: 9395: 9391: 9388: 9385: 9382: 9379: 9376: 9373: 9370: 9367: 9364: 9362: 9359: 9358: 9354: 9351: 9348: 9345: 9342: 9339: 9336: 9333: 9330: 9327: 9325: 9322: 9321: 9317: 9315: 9311: 9308: 9305: 9302: 9299: 9296: 9293: 9290: 9287: 9284: 9282: 9279: 9278: 9274: 9272: 9269: 9266: 9263: 9260: 9257: 9254: 9251: 9248: 9245: 9243: 9240: 9239: 9235: 9232: 9229: 9226: 9222:7 ± 1.61 L/kg 9216: 9206: 9203: 9200: 9193: 9190: 9188: 9185: 9184: 9180: 9178: 9175: 9172: 9169: 9166: 9163: 9160: 9157: 9154: 9151: 9149: 9146: 9145: 9141: 9138: 9136: 9132: 9128: 9125: 9122: 9119: 9116: 9113: 9110: 9107: 9104: 9101: 9099: 9096: 9095: 9091: 9088: 9085: 9083:Urine, faeces 9082: 9079: 9076: 9073: 9070: 9067: 9064: 9062: 9059: 9058: 9054: 9052: 9048: 9045: 9042: 9039: 9036: 9033: 9030: 9027: 9024: 9021: 9019: 9016: 9015: 9011: 9009: 9006: 9003: 9000: 8997: 8994: 8991: 8988: 8985: 8983:60–70% (Oral) 8982: 8980: 8977: 8976: 8972: 8969: 8966: 8964:Urine, faeces 8963: 8960: 8957: 8954: 8951: 8948: 8945: 8943: 8940: 8939: 8935: 8932: 8929: 8926: 8923: 8920: 8917: 8914: 8911: 8909:40–55% (Oral) 8908: 8906: 8903: 8902: 8898: 8895: 8893: 8889: 8886: 8883: 8880: 8877: 8874: 8871: 8868: 8865: 8863: 8860: 8859: 8856: 8853: 8851: 8847: 8843: 8840: 8837: 8834: 8831: 8828: 8825: 8822: 8819: 8816: 8814: 8811: 8810: 8806: 8804: 8801: 8799: 8795: 8791: 8788: 8785: 8782: 8779: 8776: 8773: 8770: 8768: 8765: 8764: 8760: 8758: 8755: 8752: 8749: 8746: 8743: 8740: 8737: 8734: 8731: 8729: 8726: 8725: 8721: 8719: 8715: 8711: 8708: 8705: 8702: 8699: 8696: 8693: 8690: 8687: 8684: 8682: 8679: 8678: 8674: 8672: 8668: 8665: 8662: 8658: 8655: 8653:4.9 L/kg 8652: 8649: 8646: 8643: 8640: 8637: 8635: 8632: 8631: 8627: 8624: 8621: 8618: 8616:5.8 L/kg 8615: 8610: 8607: 8604: 8601: 8598: 8596: 8593: 8592: 8588: 8585: 8582: 8579: 8577: 8571: 8569: 8563: 8561: 8555: 8552: 8547: 8541: 8539: 8536: 8533: 8532: 8529: 8528: 8523: 8507: 8501: 8498: 8495: 8494: 8493: 8488: 8485: 8482: 8479: 8478: 8477: 8476: 8472: 8471: 8466: 8462: 8459: 8456: 8453: 8450: 8447: 8444: 8441: 8438: 8435: 8432: 8429: 8426: 8423: 8420: 8417: 8414: 8411: 8408: 8407: 8403: 8400: 8397: 8394: 8391: 8388: 8385: 8382: 8379: 8376: 8373: 8370: 8367: 8364: 8361: 8358: 8355: 8352: 8349: 8348: 8344: 8341: 8338: 8335: 8332: 8329: 8326: 8323: 8320: 8317: 8314: 8311: 8308: 8305: 8302: 8299: 8296: 8293: 8290: 8289: 8285: 8282: 8279: 8276: 8273: 8270: 8267: 8264: 8261: 8258: 8255: 8252: 8249: 8246: 8243: 8240: 8237: 8234: 8231: 8230: 8226: 8223: 8220: 8217: 8214: 8211: 8208: 8205: 8202: 8199: 8196: 8193: 8190: 8187: 8184: 8181: 8178: 8175: 8172: 8171: 8167: 8164: 8161: 8158: 8155: 8152: 8149: 8146: 8143: 8140: 8137: 8134: 8131: 8128: 8125: 8122: 8119: 8116: 8113: 8112: 8108: 8105: 8102: 8099: 8096: 8093: 8090: 8087: 8084: 8081: 8078: 8075: 8072: 8069: 8066: 8063: 8060: 8057: 8054: 8053: 8049: 8046: 8043: 8040: 8037: 8034: 8031: 8028: 8025: 8022: 8019: 8016: 8013: 8010: 8007: 8004: 8001: 7998: 7995: 7994: 7990: 7987: 7984: 7981: 7978: 7975: 7972: 7969: 7966: 7963: 7960: 7957: 7954: 7951: 7948: 7945: 7942: 7939: 7937: 7936: 7935:Norquetiapine 7932: 7931: 7927: 7924: 7921: 7918: 7915: 7912: 7909: 7906: 7903: 7900: 7897: 7894: 7891: 7888: 7885: 7882: 7879: 7876: 7873: 7872: 7868: 7865: 7862: 7859: 7856: 7853: 7850: 7847: 7844: 7841: 7839:1,694.91 (HB) 7838: 7835: 7832: 7829: 7826: 7823: 7820: 7817: 7814: 7813: 7809: 7806: 7803: 7800: 7797: 7794: 7791: 7788: 7785: 7782: 7779: 7776: 7773: 7770: 7767: 7764: 7761: 7758: 7755: 7754: 7750: 7747: 7744: 7741: 7738: 7735: 7732: 7729: 7726: 7723: 7720: 7717: 7714: 7711: 7708: 7705: 7702: 7699: 7696: 7695: 7691: 7688: 7685: 7682: 7679: 7676: 7673: 7670: 7667: 7664: 7661: 7658: 7655: 7652: 7649: 7646: 7643: 7640: 7637: 7636: 7632: 7629: 7626: 7623: 7620: 7617: 7614: 7611: 7608: 7605: 7602: 7599: 7596: 7593: 7590: 7587: 7584: 7581: 7578: 7577: 7573: 7570: 7567: 7564: 7561: 7558: 7555: 7552: 7549: 7546: 7543: 7540: 7537: 7534: 7531: 7528: 7525: 7522: 7519: 7518: 7514: 7511: 7508: 7505: 7502: 7499: 7496: 7493: 7490: 7487: 7484: 7481: 7478: 7475: 7472: 7469: 7466: 7463: 7460: 7459: 7455: 7452: 7449: 7446: 7443: 7440: 7437: 7434: 7431: 7428: 7425: 7422: 7419: 7416: 7413: 7410: 7407: 7404: 7401: 7400: 7396: 7393: 7390: 7387: 7384: 7381: 7378: 7375: 7372: 7369: 7366: 7363: 7360: 7357: 7354: 7351: 7348: 7345: 7343: 7342: 7338: 7337: 7333: 7330: 7327: 7324: 7321: 7318: 7315: 7312: 7309: 7306: 7303: 7300: 7297: 7294: 7291: 7288: 7285: 7282: 7279: 7278: 7274: 7271: 7268: 7265: 7262: 7259: 7256: 7253: 7250: 7247: 7244: 7241: 7238: 7235: 7232: 7229: 7226: 7223: 7220: 7219: 7215: 7212: 7209: 7206: 7203: 7200: 7197: 7194: 7191: 7188: 7185: 7182: 7179: 7176: 7173: 7170: 7167: 7164: 7161: 7160: 7156: 7153: 7150: 7147: 7144: 7141: 7138: 7135: 7132: 7129: 7126: 7123: 7120: 7117: 7114: 7111: 7108: 7105: 7102: 7101: 7097: 7094: 7091: 7088: 7085: 7082: 7079: 7076: 7073: 7070: 7067: 7064: 7061: 7058: 7055: 7052: 7049: 7046: 7044:-Flupenthixol 7043: 7040: 7039: 7035: 7032: 7029: 7026: 7023: 7020: 7017: 7014: 7011: 7008: 7005: 7002: 6999: 6996: 6993: 6990: 6987: 6984: 6982: 6981: 6977: 6976: 6972: 6969: 6966: 6963: 6960: 6957: 6954: 6951: 6948: 6945: 6942: 6939: 6936: 6933: 6930: 6927: 6924: 6921: 6918: 6917: 6913: 6910: 6907: 6904: 6901: 6898: 6895: 6892: 6889: 6886: 6883: 6880: 6877: 6874: 6871: 6868: 6865: 6862: 6859: 6858: 6854: 6851: 6848: 6845: 6842: 6839: 6836: 6833: 6830: 6827: 6824: 6821: 6818: 6815: 6812: 6809: 6806: 6803: 6801: 6800: 6796: 6795: 6791: 6788: 6785: 6782: 6779: 6776: 6773: 6770: 6767: 6764: 6761: 6758: 6755: 6752: 6749: 6746: 6743: 6740: 6738:Brexpiprazole 6737: 6736: 6732: 6729: 6726: 6723: 6720: 6717: 6714: 6711: 6708: 6705: 6702: 6699: 6696: 6693: 6690: 6687: 6684: 6681: 6678: 6677: 6673: 6670: 6667: 6664: 6661: 6658: 6655: 6652: 6649: 6646: 6643: 6640: 6637: 6634: 6631: 6628: 6625: 6622: 6619: 6618: 6614: 6611: 6608: 6605: 6602: 6599: 6596: 6593: 6590: 6587: 6584: 6581: 6578: 6575: 6572: 6569: 6566: 6563: 6560: 6559: 6555: 6552: 6549: 6546: 6543: 6540: 6537: 6534: 6531: 6528: 6525: 6522: 6519: 6516: 6513: 6510: 6507: 6504: 6501: 6500: 6493: 6487: 6481: 6471: 6465: 6459: 6453: 6447: 6444: 6438: 6432: 6426: 6420: 6414: 6408: 6402: 6396: 6393: 6390: 6389: 6380: 6377: 6376: 6371: 6363: 6360: 6357: 6354: 6348: 6347: 6343: 6337: 6328: 6327: 6323: 6320: 6317: 6314: 6308: 6307: 6288: 6287: 6268: 6267: 6263: 6260: 6257: 6254: 6248: 6247: 6243: 6240: 6237: 6228: 6227: 6208: 6207: 6203: 6200: 6197: 6194: 6188: 6187: 6183: 6180: 6174: 6168: 6167: 6163: 6160: 6157: 6148: 6147: 6143: 6140: 6137: 6134: 6128: 6127: 6123: 6120: 6117: 6108: 6107: 6088: 6087: 6083: 6080: 6077: 6074: 6068: 6067: 6063: 6057: 6048: 6047: 6028: 6027: 6023: 6020: 6017: 6014: 6008: 6007: 6003: 6000: 5997: 5994: 5992:Schizophrenia 5991: 5988: 5987: 5982: 5970: 5964: 5961: 5958: 5955: 5954: 5953: 5951: 5947: 5942: 5940: 5936: 5934: 5930: 5928: 5924: 5922: 5918: 5916: 5912: 5911: 5910: 5909: 5905: 5904: 5900: 5899: 5893: 5889: 5880: 5862: 5860: 5857: 5856: 5852: 5810: 5807: 5806: 5802: 5745: 5742: 5741: 5737: 5728: 5695: 5692: 5691: 5687: 5660: 5658: 5655: 5654: 5650: 5646: 5604: 5601: 5600: 5596: 5554: 5551: 5550: 5546: 5489: 5486: 5485: 5481: 5422: 5419: 5418: 5414: 5410: 5383: 5381: 5378: 5377: 5372: 5368: 5361:Binds to the 5360: 5303: 5300: 5299: 5295: 5291: 5288: 5279: 5276: 5270: 5267: 5264: 5262: 5259: 5258: 5254: 5245: 5227: 5225: 5222: 5221: 5217: 5213: 5171: 5168: 5167: 5163: 5121: 5118: 5117: 5113: 5101: 5086: 5084: 5081: 5080: 5076: 5067: 5049: 5047: 5044: 5043: 5039: 5036: 5033: 5030: 5027: 5024: 5021: 5018: 5015: 4997: 4994: 4993: 4989: 4930: 4927: 4926: 4922: 4865: 4862: 4861: 4857: 4848: 4830: 4828: 4825: 4824: 4820: 4815: 4788: 4786: 4783: 4782: 4778: 4770: 4713: 4710: 4709: 4705: 4696: 4663: 4660: 4659: 4655: 4646: 4628: 4626: 4623: 4622: 4618: 4561: 4558: 4557: 4553: 4549: 4492: 4489: 4488: 4484: 4480: 4438: 4435: 4434: 4430: 4403: 4401: 4398: 4397: 4393: 4390: 4384: 4366: 4364: 4361: 4360: 4356: 4352: 4348: 4344: 4341:Notable AEs: 4340: 4298: 4295: 4294: 4290: 4286: 4244: 4241: 4240: 4236: 4207: 4204: 4203: 4199: 4142: 4139: 4138: 4134: 4126: 4091: 4061: 4058: 4057: 4053: 4026: 4024: 4021: 4020: 4016: 4012: 4009: 3952: 3949: 3948: 3944: 3942: 3939: 3937: 3934: 3932: 3929: 3926: 3924: 3920: 3918: 3915: 3913: 3910: 3908: 3905: 3902: 3899: 3897: 3893: 3890: 3886: 3885: 3880: 3869: 3866: 3863: 3860: 3857: 3854: 3852: 3849: 3848: 3845: 3842: 3839: 3836: 3833: 3830: 3828: 3825: 3824: 3821: 3818: 3815: 3812: 3809: 3806: 3804: 3801: 3800: 3797: 3794: 3791: 3788: 3785: 3782: 3780: 3777: 3776: 3773: 3770: 3767: 3764: 3761: 3758: 3756: 3753: 3752: 3749: 3746: 3743: 3740: 3737: 3734: 3732: 3729: 3728: 3725: 3722: 3719: 3716: 3713: 3710: 3708: 3705: 3704: 3701: 3698: 3695: 3692: 3689: 3686: 3684: 3681: 3680: 3677: 3674: 3671: 3668: 3665: 3662: 3660: 3657: 3656: 3653: 3650: 3647: 3644: 3641: 3638: 3636: 3633: 3632: 3629: 3626: 3623: 3620: 3617: 3614: 3612: 3609: 3608: 3605: 3602: 3599: 3596: 3593: 3591:Butyrophenone 3590: 3588: 3585: 3584: 3581: 3578: 3575: 3572: 3569: 3566: 3564: 3561: 3560: 3557: 3554: 3551: 3548: 3545: 3543:Benzisoxazole 3542: 3540: 3537: 3536: 3533: 3530: 3527: 3524: 3521: 3518: 3516: 3513: 3512: 3509: 3506: 3503: 3500: 3497: 3494: 3492: 3489: 3488: 3485: 3482: 3479: 3476: 3473: 3470: 3468: 3465: 3464: 3461: 3458: 3455: 3452: 3449: 3446: 3444: 3441: 3440: 3437: 3434: 3431: 3428: 3425: 3422: 3420: 3417: 3416: 3413: 3410: 3407: 3404: 3401: 3399:Butyrophenone 3398: 3396: 3393: 3392: 3389: 3386: 3383: 3380: 3377: 3374: 3372: 3369: 3368: 3365: 3362: 3359: 3356: 3353: 3350: 3348: 3345: 3344: 3341: 3338: 3335: 3332: 3329: 3326: 3324: 3321: 3320: 3317: 3314: 3311: 3308: 3305: 3302: 3300: 3297: 3296: 3293: 3291:Rhône-Poulenc 3290: 3287: 3284: 3281: 3278: 3276: 3273: 3272: 3269: 3266: 3263: 3260: 3257: 3254: 3252: 3249: 3248: 3245: 3242: 3239: 3236: 3233: 3230: 3228: 3225: 3224: 3221: 3218: 3215: 3212: 3209: 3207:Benzisoxazole 3206: 3204: 3201: 3200: 3197: 3194: 3191: 3188: 3185: 3183:Benzisoxazole 3182: 3180: 3177: 3176: 3173: 3170: 3167: 3164: 3161: 3158: 3156: 3153: 3152: 3149: 3146: 3143: 3140: 3137: 3134: 3132: 3129: 3128: 3125: 3122: 3119: 3116: 3113: 3110: 3108: 3105: 3104: 3101: 3098: 3095: 3092: 3089: 3086: 3084: 3081: 3080: 3077: 3074: 3071: 3068: 3065: 3062: 3060: 3057: 3056: 3053: 3050: 3047: 3044: 3041: 3039:Butyrophenone 3038: 3036: 3033: 3032: 3029: 3026: 3023: 3020: 3017: 3014: 3012: 3009: 3008: 3005: 3002: 2999: 2996: 2993: 2990: 2988: 2985: 2984: 2981: 2978: 2975: 2972: 2969: 2966: 2964: 2963:Levosulpiride 2961: 2960: 2957: 2955:Rhône-Poulenc 2954: 2951: 2948: 2945: 2942: 2940: 2937: 2936: 2933: 2930: 2927: 2924: 2921: 2919:Benzisoxazole 2918: 2916: 2913: 2912: 2909: 2906: 2903: 2900: 2897: 2895:Butyrophenone 2894: 2892: 2889: 2888: 2885: 2882: 2879: 2876: 2873: 2870: 2868: 2865: 2864: 2861: 2858: 2855: 2852: 2849: 2846: 2844: 2841: 2840: 2837: 2834: 2831: 2828: 2825: 2822: 2820: 2817: 2816: 2813: 2811:Janssen-Cilag 2810: 2807: 2804: 2801: 2799:Butyrophenone 2798: 2796: 2793: 2792: 2789: 2786: 2783: 2780: 2777: 2774: 2772: 2769: 2768: 2765: 2762: 2759: 2756: 2753: 2750: 2748: 2745: 2744: 2741: 2739:Sandoz/Wander 2738: 2735: 2732: 2729: 2726: 2724: 2721: 2720: 2717: 2714: 2711: 2708: 2705: 2702: 2700: 2697: 2696: 2693: 2690: 2687: 2684: 2681: 2678: 2676: 2673: 2672: 2669: 2666: 2663: 2660: 2657: 2654: 2652: 2649: 2648: 2645: 2642: 2639: 2636: 2633: 2630: 2628: 2625: 2624: 2621: 2618: 2615: 2612: 2609: 2606: 2604: 2601: 2600: 2597: 2594: 2591: 2588: 2585: 2582: 2580: 2577: 2576: 2573: 2570: 2567: 2564: 2561: 2558: 2556: 2553: 2552: 2549: 2546: 2543: 2540: 2537: 2535:Butyrophenone 2534: 2532: 2529: 2528: 2525: 2522: 2519: 2516: 2513: 2510: 2508: 2507:Brexpiprazole 2505: 2504: 2501: 2498: 2495: 2492: 2489: 2486: 2484: 2481: 2480: 2477: 2474: 2471: 2468: 2465: 2463:Butyrophenone 2462: 2460: 2457: 2456: 2453: 2451:Organon/Merck 2450: 2447: 2444: 2441: 2438: 2436: 2433: 2432: 2429: 2426: 2423: 2420: 2417: 2414: 2412: 2409: 2408: 2405: 2402: 2399: 2396: 2393: 2390: 2388: 2385: 2384: 2381: 2378: 2375: 2372: 2369: 2366: 2364: 2361: 2360: 2356: 2353: 2350: 2348:Brand name(s) 2347: 2344: 2341: 2338: 2337: 2334: 2333: 2328: 2320: 2306: 2297: 2295: 2287: 2280: 2269: 2265: 2263: 2259: 2255: 2250: 2242: 2238: 2234: 2229: 2227: 2215: 2211: 2202: 2199: 2195: 2191: 2187: 2180: 2176: 2172: 2156:-preferring D 2151: 2148: 2133: 2132:Brilaroxazine 2130: 2123: 2122:Brexpiprazole 2120: 2117: 2114: 2107: 2104: 2103: 2085: 2082: 2081: 2075: 2073: 2061: 2058: 2041: 2037: 2033: 2030: 2027: 2019: 2016: 2013: 2010: 2009: 2000: 1996: 1993: 1990: 1986: 1982: 1977: 1973: 1970: 1967: 1963: 1959: 1955: 1951: 1947: 1944: 1941: 1937: 1933: 1930: 1927: 1924: 1923: 1914: 1911: 1908: 1905: 1904: 1895: 1892: 1889: 1888:heart disease 1885: 1881: 1878: 1875: 1871: 1867: 1864: 1861: 1858: 1855: 1852: 1849: 1845: 1841: 1837: 1834: 1833: 1824: 1821: 1814: 1810: 1806: 1802: 1799: 1796: 1793: 1790: 1786: 1782: 1778: 1774: 1771: 1770: 1763: 1751: 1748: 1747: 1739: 1736: 1734: 1731: 1729: 1726: 1724: 1721: 1719: 1716: 1714: 1711: 1710: 1702: 1699: 1697: 1694: 1692: 1689: 1688: 1682: 1672: 1669: 1667: 1664: 1662: 1659: 1657: 1654: 1652: 1649: 1648: 1646: 1645:Thioxanthenes 1639:Thioxanthenes 1633: 1629: 1626: 1624: 1621: 1618: 1614: 1611: 1608: 1605: 1603: 1600: 1598: 1595: 1592: 1588: 1585: 1583: 1580: 1578: 1575: 1573: 1570: 1568: 1565: 1563: 1560: 1557: 1553: 1550: 1548: 1545: 1543: 1540: 1538: 1535: 1533: 1530: 1527: 1524: 1521: 1518: 1517: 1515: 1503: 1500: 1497: 1494: 1491: 1488: 1487: 1479: 1476: 1473: 1469: 1466: 1463: 1459: 1456: 1453: 1450: 1448: 1445: 1443: 1440: 1438: 1435: 1434: 1432: 1421: 1411: 1410: 1406: 1405: 1401: 1400: 1396: 1395: 1391: 1383: 1375: 1367: 1358: 1355: 1350: 1347: 1343: 1339: 1334: 1332: 1328: 1326: 1321: 1317: 1314: 1313: 1306: 1296: 1294: 1290: 1285: 1282: 1277: 1273: 1270: 1265: 1263: 1259: 1255: 1249: 1237: 1236:Pisa syndrome 1234: 1232: 1229: 1227: 1224: 1222: 1219: 1216: 1213: 1211: 1208: 1205: 1202: 1200: 1197: 1192: 1188: 1185: 1182: 1179: 1176: 1175: 1173: 1170: 1167: 1163: 1156: 1148: 1144: 1140: 1137: 1134: 1133: 1132: 1131: 1129: 1120: 1119:Breast cancer 1117: 1114: 1110: 1107: 1102: 1099: 1096: 1093: 1092: 1090: 1087: 1083: 1080: 1075: 1072: 1069: 1068:Gynaecomastia 1066: 1063: 1062:Galactorrhoea 1060: 1059: 1057: 1054: 1049: 1046: 1043: 1040: 1037: 1034: 1033: 1031: 1028: 1025: 1022: 1019: 1016: 1013: 1010: 1009: 1008: 1007: 1005: 994: 990: 987: 983: 979: 975: 971: 967: 963: 958: 956: 952: 948: 944: 939: 937: 933: 929: 925: 921: 917: 913: 908: 903: 893: 890: 888: 883: 877: 874: 871: 867: 863: 859: 855: 850: 847: 845: 841: 836: 834: 830: 826: 822: 818: 808: 806: 800: 798: 794: 790: 785: 783: 779: 775: 771: 767: 763: 759: 755: 751: 746: 744: 740: 736: 732: 728: 724: 720: 716: 712: 708: 704: 700: 696: 692: 688: 677: 674: 670: 665: 663: 659: 655: 645: 643: 639: 635: 631: 628:approval and 627: 617: 614: 610: 605: 603: 599: 595: 591: 587: 583: 579: 574: 572: 568: 564: 558: 548: 546: 541: 539: 535: 529: 525: 521: 512: 503: 499: 496: 491: 489: 485: 481: 470: 461: 457: 455: 451: 447: 443: 439: 435: 429: 422:Schizophrenia 419: 417: 413: 409: 405: 401: 397: 392: 390: 386: 378: 375: 372: 369: 366: 363: 360: 356: 352: 349: 347: 346:Schizophrenia 344: 343: 342: 334: 332: 328: 324: 318: 312: 306: 300: 296: 292: 288: 284: 280: 276: 272: 268: 263: 262: 258: 254: 250: 246: 242: 238: 234: 230: 225: 223: 218: 213: 211: 207: 203: 202:schizophrenia 199: 195: 191: 187: 183: 179: 175: 171: 167: 159: 155: 150: 146: 142: 140: 136: 131: 127: 123: 121: 117: 114:Clinical data 112: 109: 105: 101: 97: 93: 89: 88:Schizophrenia 86:Principally: 85: 81: 77: 75: 71: 66: 61: 57: 52: 47: 44: 43: 38: 35:Antipsychotic 33: 30: 19: 27436:Mogens Schou 27305: 27272:Escitalopram 27101: 26863: 26854: 26845: 26836: 26827: 26818: 26807: 26806: 26759:Stepholidine 26754:Spiroxatrine 26744:Seridopidine 26739:SB-277,011-A 26659:Fenfluramine 26619:Bromerguride 26599: 26593:Trimipramine 26588:Propiomazine 26568: 26547:Promethazine 26542:Metopimazine 26472: 26391:Paliperidone 26336:Fluperlapine 26326:Elopiprazole 26291:Clocapramine 26281:Carpipramine 26256: 26210:Thioridazine 26170:Prothipendyl 26130:Perphenazine 26090:Mesoridazine 26065:Homopipramol 26055:Fluspirilene 26045:Fluphenazine 26000:Clothixamide 25995:Clopenthixol 25970:Chloracizine 25965:Butaperazine 25935:Acepromazine 25930: 25890:Salvinorin A 25700: 25694:Norclozapine 25689:Lumateperone 25649:Aripiprazole 25639: 25579: 25548: 25502:Chanoclavine 25487: 25456: 25435: 25368: 25332:Paliperidone 25312:Norclozapine 25302:Fluperlapine 25272: 25246:Thioridazine 25231:Perphenazine 25221:Fluphenazine 25191: 25161: 25136:Stepholidine 25081: 25016: 24975: 24934: 24884:Benzazepines 24883: 24595:Psychedelics 24565:Aphrodisiacs 24554: 24239:infestations 24215:Sex hormones 24168:Sex hormones 24113:Cicatrizants 24043: 24029:Vasodilators 23996:antianginals 23993: 23845:stomach acid 23844: 23735: 23712: 23692:Pimavanserin 23683: 23666:+samidorphan 23645: 23617:Aripiprazole 23612:quinolinones 23606: 23600:Lumateperone 23593: 23565:Paliperidone 23544: 23523: 23492:Clocapramine 23487:Carpipramine 23480: 23467: 23419: 23363:Clopenthixol 23351: 23335:Thioridazine 23266:Perphenazine 23251:Mesoridazine 23229:Fluphenazine 23204:Butaperazine 23194:Acepromazine 23187: 23171:Fluspirilene 23164: 23097: 23076: 23030: 22947:(1): 13–22. 22944: 22940: 22889: 22885: 22854: 22850: 22834:. Retrieved 22824: 22806:cite journal 22771: 22767: 22750:. Retrieved 22735: 22722: 22677: 22673: 22652: 22617: 22613: 22587:(12): 1693. 22584: 22580: 22553: 22540:. Retrieved 22521: 22489:cite journal 22464: 22460: 22454: 22445: 22435: 22426:the original 22420: 22394: 22384: 22375: 22366: 22351: 22342: 22333: 22325:The Guardian 22324: 22314: 22305: 22301: 22245: 22241: 22231: 22219: 22207: 22170: 22166: 22156: 22146:29 September 22144:. Retrieved 22134: 22115: 22093:(12): 1693. 22090: 22086: 22080: 22045: 22039: 22019: 22012: 21996: 21991: 21972: 21962: 21943: 21937: 21904: 21900: 21890: 21866: 21859: 21832: 21826: 21814:. Retrieved 21809: 21800: 21791: 21785: 21773:. Retrieved 21769:the original 21748: 21744: 21721: 21712: 21708: 21702: 21677: 21673: 21667: 21645:(1): 31–49. 21642: 21638: 21632: 21615: 21611: 21604: 21595: 21589: 21554: 21550: 21520: 21516: 21510: 21501: 21467: 21463: 21445: 21441: 21435: 21426: 21409: 21405: 21399: 21366: 21362: 21356: 21323: 21319: 21313: 21280: 21276: 21269: 21244: 21240: 21234: 21204:(2): 173–6. 21201: 21197: 21191: 21158: 21154: 21147: 21134: 21125: 21110: 21101: 21082: 21073: 21054: 21045: 21008: 21004: 20994: 20961: 20957: 20950: 20925: 20921: 20881:(1): 65–73. 20878: 20874: 20868: 20856:. Retrieved 20852:the original 20847: 20830: 20797: 20793: 20787: 20776: 20739: 20735: 20725: 20688: 20684: 20674: 20649: 20643: 20608: 20604: 20597: 20564: 20560: 20554: 20517: 20513: 20503: 20466: 20462: 20452: 20419: 20415: 20408: 20396:. Retrieved 20391: 20382: 20347: 20343: 20333: 20300: 20296: 20290: 20255: 20251: 20241: 20206: 20196: 20171: 20165: 20130: 20126: 20116: 20104:. 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Retrieved 11967: 11934: 11895:(3): 191–8. 11892: 11888: 11881: 11848: 11844: 11802: 11798: 11738: 11734: 11688: 11684: 11678: 11653: 11649: 11643: 11634: 11625: 11618:paliperidone 11608: 11573: 11569: 11523: 11519: 11475: 11471: 11425: 11421: 11415: 11407: 11385: 11381: 11371: 11338: 11334: 11293: 11289: 11279: 11256:Pharmacology 11255: 11226: 11191:parkinsonism 11187: 11175: 11159: 11123: 11103: 11097: 11088:aripiprazole 11065: 11031: 11028:Formulations 11015: 11006: 10993: 10989: 10980:psychoactive 10977: 10972: 10968: 10964: 10956: 10952: 10950: 10925: 10894: 10886: 10882: 10866: 10850: 10835:tranquilizer 10831: 10807: 10784: 10751: 10748: 10710: 10702: 10615:21 days 10608:Microspheres 10473:27 days 10364:30 days 10267:Fluspirilene 10182:17 days 10145:19 days 9907:20 L/kg 9864:10 L/kg 9687:Thioridazine 9628:20 L/kg 9602:Paliperidone 9505:Oral, IM, IV 9487:6.8–9 h 9398:Perphenazine 9281:Paliperidone 9224:(20 mg) 9004:Oral, IM, IV 8942:Fluphenazine 8855:Norclozapine 8786:20 L/kg 8741:1.5–2 h 8738:≥ 99.7% 8697:4 ng/mL 8634:Aripiprazole 8612:54 ± 4 ng/mL 8548:parent drug 8505: 8489:ND – No data 8469: 8468: 8173:Thioridazine 7934: 7933: 7697:Perphenazine 7638:Paliperidone 7340: 7339: 7103:Fluphenazine 7041: 6980:Norclozapine 6979: 6978: 6798: 6797: 6561:Aripiprazole 6229:Paliperidone 6029:Aripiprazole 5968: 5949: 5948: 5907: 5906: 5896: 5895: 5649:tuberculosis 5603:Thioridazine 5370: 5215: 5120:Perphenazine 4929:Paliperidone 4551: 4482: 4437:Fluphenazine 4400:Flupenthixol 4347:neutropaenia 4288: 4060:Aripiprazole 3930: 3895: 3887:Generic name 3659:Thioridazine 3347:Pimavanserin 3323:Perphenazine 3179:Paliperidone 3059:Mesoridazine 2867:Fluspirilene 2843:Fluphenazine 2675:Clopenthixol 2651:Clocapramine 2595:Pierre Fabre 2579:Carpipramine 2387:Aripiprazole 2339:Generic name 2298: 2266: 2262:thioridazine 2249:side effects 2243:. Blocking D 2230: 2212:. Different 2203: 2168: 2106:Aripiprazole 2084:Lumateperone 2050: 2018:Pimavanserin 1913:Lumateperone 1854:Paliperidone 1718:Clocapramine 1713:Carpipramine 1680: 1656:Clopenthixol 1632:discontinued 1631: 1617:discontinued 1616: 1613:Thioridazine 1602:Prothipendyl 1597:Promethazine 1591:discontinued 1590: 1572:Perphenazine 1556:discontinued 1555: 1552:Mesoridazine 1542:Fluphenazine 1520:Acepromazine 1490:Fluspirilene 1472:discontinued 1471: 1462:discontinued 1461: 1408: 1407: 1403: 1402: 1398: 1397: 1393: 1392: 1388: 1351: 1345: 1335: 1329: 1322: 1318: 1310: 1308: 1286: 1278: 1274: 1266: 1262:polypharmacy 1251: 1199:Pancreatitis 1127: 1125: 1124: 1112: 1097:Constipation 1076:Osteoporosis 1003: 1001: 1000: 991: 959: 940: 909: 906: 891: 878: 875: 851: 848: 837: 814: 801: 786: 778:aripiprazole 747: 745:guidelines. 739:primary care 723:dyslipidemia 683: 666: 651: 623: 606: 597: 578:lumateperone 575: 560: 542: 530: 526: 522: 518: 509: 500: 492: 476: 467: 458: 440:(NICE), the 431: 400:Aripiprazole 393: 382: 340: 337:Medical uses 331:neurological 326: 323:take hold of 322: 310: 294: 269:), known as 264: 233:gynecomastia 226: 217:white matter 214: 173: 170:neuroleptics 169: 165: 164: 152:Legal status 126:Drug Classes 59: 40: 29: 27255:and similar 27216:Lamotrigine 27109:Hypersomnia 26949:Bipolar NOS 26944:Cyclothymia 26820:Adrenergics 26724:Pridopidine 26709:Nafadotride 26694:Metergoline 26609:Alpiropride 26557:Trazpiroben 26527:Hydroxyzine 26522:Eticlopride 26517:Domperidone 26487:Alimemazine 26461:Ziprasidone 26456:Zicronapine 26451:Veralipride 26436:Tefludazine 26426:Risperidone 26421:Remoxipride 26406:Pipotiazine 26396:Perospirone 26385:+fluoxetine 26376:Ocaperidone 26371:Mosapramine 26356:Mazapertine 26346:Iloperidone 26341:Gevotroline 26331:Flumezapine 26311:Cyamemazine 26296:Clorotepine 26276:Blonanserin 26261:Amisulpride 26215:Thiothixene 26150:Pipamperone 26115:Perathiepin 26110:Penfluridol 26105:Nemonapride 26060:Haloperidol 26039:+melitracen 26005:Clopimozide 25955:Bromperidol 25924:Antagonists 25915:WAY-100,635 25860:Quinelorane 25855:Quinagolide 25835:Pramipexole 25800:Pardoprunox 25785:Mesulergine 25775:Flibanserin 25765:Dizocilpine 25745:Armodafinil 25735:Apomorphine 25679:Cariprazine 25653:+sertraline 25594:Etilevodopa 25517:Ergocornine 25512:Epicriptine 25497:Cabergoline 25450:Rimantadine 25436:Adamantanes 25357:Ziprasidone 25352:Zicronapine 25347:Tefludazine 25342:Risperidone 25326:+fluoxetine 25307:Iloperidone 25282:Clorotepine 25251:Thiothixene 25241:Pifluthixol 25215:+melitracen 25185:Antagonists 25091:Apomorphine 25036:Etilevodopa 25010:Doxanthrine 25000:Dinapsoline 24939:Cabergoline 24728:Otologicals 24700:antagonists 24666:respiratory 24641:Orexigenics 24636:Neurotoxins 24585:Euphoriants 24575:Entactogens 24570:Depressants 24560:Anxiolytics 24498:Anesthetics 24274:Antifungals 23871:Antiemetics 23859:antagonists 23760:from market 23739:Azacyclonol 23687:Blonanserin 23639:Cariprazine 23587:Ziprasidone 23582:Risperidone 23577:Perospirone 23555:Iloperidone 23512:Mosapramine 23497:Clorotepine 23461:Veralipride 23441:Remoxipride 23436:Nemonapride 23426:Amisulpride 23375:Flupentixol 23293:Pipotiazine 23261:Periciazine 23219:Cyamemazine 23176:Penfluridol 23143:Pipamperone 23126:Haloperidol 23109:Bromperidol 22542:30 December 22308:(5): 77–79. 21775:26 February 20858:11 November 20691:: 3081704. 20520:(1): 5–14. 20469:: 235–245. 20303:(1): 41–9. 19757:"Clozapine" 19428:AdisInsight 19410:AdisInsight 19217:AdisInsight 19199:AdisInsight 19181:AdisInsight 19151:AdisInsight 19064:AdisInsight 18687:AdisInsight 18657:AdisInsight 18639:AdisInsight 18621:AdisInsight 18617:"Asenapine" 18603:AdisInsight 18311:10230/25548 17911:: 124–151. 17853:20 November 17477:(1): 3–13. 17165:: 8213165. 16611:(1): 1–11. 15476:30 December 13821:(1): 6–17. 13084:10 December 11614:risperidone 11151:AstraZeneca 11119:risperidone 11094:Controversy 11050:transdermal 11034:dorsgluteal 10973:neuroleptic 10957:neuroleptic 10947:Terminology 10851:neuroleptic 10849:. The word 10814:anxiolytics 10595:Risperidone 10358:7 days 10290:7 days 10253:4 days 10179:8 days 10065:7 days 9867:Urine (17%) 9802:Ziprasidone 9581:3–17 h 9568:Risperidone 9502:Urine, bile 9361:Perospirone 9324:Periciazine 9196:6.6 ± 3.7 h 9037:1340–2800 L 9018:Iloperidone 8979:Haloperidol 8946:2.7% (Oral) 8905:Flupentixol 8875:60 min (IM) 8747:8560–9500 L 8728:Blonanserin 8595:Amisulpride 8404:>10,000 8350:Ziprasidone 8286:>10,000 8050:>10,000 7996:Risperidone 7866:555.55 (HB) 7692:>10,000 7574:>10,000 7515:>10,000 7456:>10,000 7275:>10,000 7221:Iloperidone 7216:>10,000 7162:Haloperidol 6792:>10,000 6679:Blonanserin 6556:>10,000 6502:Amisulpride 6329:Ziprasidone 6289:Risperidone 6249:Perospirone 6129:Iloperidone 6109:Haloperidol 6009:Amisulpride 5939:QT interval 5744:Ziprasidone 5421:Risperidone 5380:Remoxipride 5371:hit and run 5224:Pipotiazine 5083:Perospirone 5046:Periciazine 4560:Iloperidone 4491:Haloperidol 4355:myocarditis 4351:leukopaenia 4206:Blonanserin 3951:Amisulpride 3941:Hypotension 3917:Weight Gain 3803:Ziprasidone 3779:Veralipride 3539:Risperidone 3531:AstraZeneca 3515:Remoxipride 3507:AstraZeneca 3419:Pipotiazine 3395:Pipamperone 3299:Perospirone 3275:Periciazine 3227:Penfluridol 3131:Nemonapride 3107:Mosapramine 2915:Iloperidone 2891:Haloperidol 2819:Flupentixol 2771:Cyamemazine 2699:Clorotepine 2555:Cariprazine 2531:Bromperidol 2483:Blonanserin 2363:Amisulpride 2254:haloperidol 2216:of the 5-HT 2171:haloperidol 2150:Cariprazine 2036:H. Lundbeck 2012:Blonanserin 1884:QT interval 1880:Ziprasidone 1866:Risperidone 1860:Perospirone 1840:hypotension 1836:Iloperidone 1801:Remoxipride 1795:Nemonapride 1773:Amisulpride 1738:Mosapramine 1723:Clorotepine 1701:Veralipride 1666:Thiothixene 1661:Flupentixol 1577:Pipotiazine 1567:Pericyazine 1532:Cyamemazine 1528:(Thorazine) 1496:Penfluridol 1468:Pipamperone 1452:Haloperidol 1442:Bromperidol 1377:Haloperidol 1342:dyskinesias 1338:cholinergic 1269:grey matter 1204:QT interval 1152:histamine H 970:myocarditis 964:(including 947:neutropenia 924:haloperidol 916:Risperidone 866:ziprasidone 858:risperidone 829:risperidone 821:Amisulpride 774:risperidone 727:neutropenia 711:risperidone 611:and the UK 598:maintenance 582:cariprazine 295:Neuroleptic 283:risperidone 241:weight gain 184:(including 158:In Wikidata 18:Neuroleptic 27451:Categories 27287:Sertraline 27277:Fluoxetine 27097:Mood swing 26984:Depression 26939:Bipolar II 26729:Raclopride 26719:PNU-99,194 26714:Nuciferine 26654:Fananserin 26649:Fallypride 26578:Nefazodone 26507:Clebopride 26502:Bromopride 26492:Alizapride 26446:Tiospirone 26441:Tenilapine 26431:Sertindole 26416:Quetiapine 26411:Piquindone 26381:Olanzapine 26351:Lurasidone 26321:Dixyrazine 26286:Cinuperone 26245:Zetidoline 26220:Timiperone 26195:Teflutixol 26190:Sultopride 26030:Fluotracen 26025:Flucindole 26020:Fluanisone 26015:Fluacizine 26010:Droperidol 25990:Ciclindole 25960:Butaclamol 25950:Benperidol 25910:Umespirone 25905:Talipexole 25900:Sumanirole 25895:SKF-83,959 25880:Ropinirole 25865:Quinpirole 25820:PF-592,379 25815:PF-219,061 25810:PD-168,077 25805:PD-128,907 25770:Esketamine 25760:CP-226,269 25755:Captodiame 25740:Arketamine 25664:Bifeprunox 25628:Melevodopa 25589:Dopexamine 25568:Dinoxyline 25522:Lergotrile 25476:Rotigotine 25440:Amantadine 25337:Quetiapine 25322:Olanzapine 25287:Clotiapine 25196:Butaclamol 25131:SKF-89,626 25126:SKF-89,145 25121:Rotigotine 25111:PF 6669571 25106:PF-6649751 25101:Nuciferine 25054:Melevodopa 25031:Dopexamine 25005:Dinoxyline 24944:CY-208,243 24928:Zelandopam 24918:SKF-83,959 24913:SKF-82,958 24908:SKF-81,297 24903:SKF-77,434 24898:SKF-38,393 24893:Fenoldopam 24857:modulators 24651:Stimulants 24631:Nootropics 24605:Deliriants 24580:Entheogens 24515:Anorectics 24493:Analgesics 24346:Alkylating 24279:Antivirals 24234:infections 24108:Emollients 23962:Coagulants 23832:metabolism 23719:Oxypertine 23697:Sertindole 23672:Quetiapine 23662:Olanzapine 23647:Tricyclics 23560:Lurasidone 23502:Clotiapine 23482:Tricyclics 23451:Sultopride 23421:Benzamides 23224:Dixyrazine 23153:Timiperone 23121:Droperidol 23104:Benperidol 23029:FROTA LH. 22836:23 October 20626:2445/51726 20537:2445/53243 20398:2 November 20388:"Zotepine" 20106:3 November 19988:5 November 19767:2 November 19717:: 587–94. 18801:ChemInform 18243:: 681539. 15533:27 October 14752:(5): 355. 14504:Pediatrics 14205:: 113098. 13509:Psychiatry 11341:: 114405. 11238:References 11084:Olanzapine 11080:quetiapine 10905:anxiolytic 10822:Jean Delay 10791:anesthetic 10711:Footnotes: 10571:Sesame oil 10497:Sesame oil 10460:Sesame oil 10317:Sesame oil 10243:Sesame oil 10206:Sesame oil 10095:Sesame oil 9967:Brand name 9964:Medication 9858:1-4 h 9661:3-6 h 9609:Sertindole 9517:Quetiapine 9450:6–8 h 9374:1.5 h 9285:28% (Oral) 9246:87% (Oral) 9242:Olanzapine 9161:1–3 h 9148:Lurasidone 9074:2–3 h 9031:2–4 h 8862:Droperidol 8706:Sublingual 8647:3–5 h 8608:3–4 h 8401:>10,000 8283:>10,000 8262:>10,000 8147:>10,000 8138:4,893 (RB) 8132:4,000 (RC) 8129:5,000 (RC) 8120:>10,000 8055:Sertindole 8047:>10,000 8026:>10,000 7999:>10,000 7904:>10,000 7877:>10,000 7874:Quetiapine 7863:18.86 (HB) 7821:5,900 (HC) 7789:>10,000 7689:>10,000 7668:>10,000 7609:>10,000 7579:Olanzapine 7532:>10,000 7512:>10,000 7476:1,254 (RC) 7473:2,100 (HB) 7467:2,200 (HB) 7453:>10,000 7450:>10,000 7402:Lurasidone 7283:>10,000 7213:>10,000 7056:102.2 (RC) 7053:87.5 (HFC) 6553:>10,000 6550:>10,000 6535:>10,000 6532:>10,000 6523:>10,000 6514:>10,000 6508:>10,000 6505:>10,000 6309:Sertindole 6269:Quetiapine 6209:Olanzapine 6169:Lurasidone 5921:Odds ratio 5488:Sertindole 5302:Quetiapine 5294:antiemetic 4864:Olanzapine 4712:Lurasidone 4363:Droperidol 3921:Metabolic 3635:Sultopride 3597:Spiropitan 3563:Sertindole 3491:Quetiapine 3155:Olanzapine 3147:Yamanouchi 3011:Lurasidone 2795:Droperidol 2723:Clotiapine 2459:Benperidol 2239:, and the 2146:antagonist 2095:valproate. 2040:antagonist 2032:Sertindole 1972:Quetiapine 1962:fluoxetine 1946:Olanzapine 1920:Tricyclics 1894:Lurasidone 1848:somnolence 1823:Sultopride 1781:anxiolytic 1767:Benzamides 1728:Clotiapine 1707:Tricyclics 1696:Sultopride 1685:Benzamides 1537:Dixyrazine 1478:Timiperone 1447:Droperidol 1437:Benperidol 1385:Quetiapine 1303:See also: 1246:See also: 873:symptoms. 862:quetiapine 825:olanzapine 658:fluoxetine 594:quetiapine 590:olanzapine 586:lurasidone 412:Quetiapine 56:Olanzapine 42:Drug class 27421:John Cade 27262:Bupropion 27226:Valproate 27194:Treatment 27146:Diagnosis 27121:Psychosis 27080:Dysphoria 27075:Anhedonia 26997:Dysthymia 26959:Hypomania 26954:Childhood 26934:Bipolar I 26808:See also: 26789:Yohimbine 26769:Terguride 26734:Sarizotan 26679:L-745,870 26674:L-741,626 26629:Buspirone 26583:Opipramol 26573:Amoxapine 26366:Molindone 26361:Melperone 26306:Clozapine 26266:Asenapine 26185:Sulpiride 26165:Promazine 26155:Preclamol 26070:Lenperone 25945:Azaperone 25885:Roxindole 25875:Ro10-5824 25850:Pukateine 25840:Preclamol 25830:Piribedil 25790:Modafinil 25730:Aplindore 25725:Adrafinil 25623:-Tyrosine 25599:Ibopamine 25542:Terguride 25537:Pergolide 25488:Ergolines 25471:8-OH-PBZI 25466:7-OH-DPAT 25461:5-OH-DPAT 25445:Memantine 25403:SCH-23390 25398:Perlapine 25373:Berupipam 25292:Clozapine 25277:Asenapine 25176:Mevidalen 25141:Tavapadon 25070:-Tyrosine 25041:Ibopamine 24969:Terguride 24964:Pergolide 24935:Ergolines 24801:ATC codes 24767:Dressings 24752:Antidotes 24616:Sedatives 24612:Hypnotics 24321:malignant 24178:endocrine 24024:Diuretics 23957:Platelets 23917:and blood 23876:Laxatives 23770:Phase III 23758:Withdrawn 23724:Reserpine 23657:Clozapine 23652:Asenapine 23527:Molindone 23474:Melperone 23446:Sulpiride 23315:Promazine 23148:Spiperone 22173:(1): 10. 21929:195797603 21470:: 41–54. 21448:(1): 1–6. 21406:CNS Drugs 21112:Daily Med 20903:206489515 20844:Database" 20794:CNS Drugs 20078:262520276 20050:CNS Drugs 19661:CNS Drugs 19641:205710487 19046:247414112 19038:0924-9338 18821:0931-7597 18807:(9): no. 18092:2305-0500 17848:Drugs.com 17822:1079-2082 17740:262520276 17712:CNS Drugs 17118:CiteSeerX 17046:205679212 16080:207492339 16002:252088054 15170:1075-2730 14932:CiteSeerX 14687:255703855 14638:258224542 14356:253467990 14288:250536370 14229:230507941 14000:1179-1934 13980:CNS Drugs 13943:0004-8674 13894:1873-7862 13837:0001-690X 13422:205173641 13164:2 October 13148:Lowes R. 12803:221306099 12743:207408308 11691:: 20–41. 11450:205976059 11363:246054926 11171:Risperdal 11111:kickbacks 11046:asenapine 10951:The term 10896:ataraktos 10891:ἀτάρακτος 10847:sedatives 10843:reserpine 10726:viscosity 10724:. = Low- 9895:20 h 9772:24 h 9733:24 h 9726:Tiotixene 9694:24 h 9648:Sulpiride 9622:10 h 9444:55 h 9331:12 h 9300:390–487 L 9249:30 h 9187:Melperone 9181:2 active 9155:18 h 9140:Amoxapine 9068:30 h 8912:35 h 8872:Extensive 8820:12 h 8813:Clozapine 8774:30 h 8688:24 h 8681:Asenapine 8602:12 h 8580:Excretion 8232:Tiotixene 8159:>1,000 8114:Sulpiride 8106:>5,000 7988:38.3 (RC) 7970:99.8 (RC) 7836:23.8 (HB) 7520:Molindone 7461:Melperone 7341:Amoxapine 6994:11.9 (RC) 6919:Clozapine 6700:26.7 (RB) 6620:Asenapine 6391:Drug name 6189:Melperone 6089:Clozapine 6049:Asenapine 5984:Efficacy 5657:Tiotixene 5553:Sulpiride 4827:Molindone 4785:Melperone 4297:Clozapine 4141:Asenapine 4090:akathisia 4023:Amoxapine 3783:Benzamide 3741:Stelazine 3707:Tiotixene 3693:Tiapridal 3687:Benzamide 3639:Benzamide 3615:Benzamide 3611:Sulpiride 3587:Spiperone 3573:Serdolect 3549:Risperdal 3519:Benzamide 3467:Promazine 3453:Compazine 3405:Dipiperon 3135:Benzamide 3083:Molindone 3035:Melperone 2973:Levopraid 2967:Benzamide 2747:Clozapine 2667:Yoshitomi 2613:Thorazine 2435:Asenapine 2367:Benzamide 2330:Overview 2210:receptors 2186:receptors 1997:– Of the 1932:Clozapine 1926:Asenapine 1915:(Caplyta) 1907:Melperone 1844:dizziness 1819:receptor. 1785:dysthymia 1750:Molindone 1691:Sulpiride 1587:Promazine 1281:akathisia 1086:metformin 1036:Akathisia 1020:Dizziness 1017:Headaches 953:(lowered 842:(lowered 833:clozapine 571:valproate 279:clozapine 237:impotence 186:delusions 182:psychosis 120:Drugs.com 27114:Insomnia 27060:Delusion 27052:Symptoms 26917:Spectrum 26779:Tiapride 26689:LEK-8829 26614:Azapride 26532:Itopride 26466:Zotepine 26145:Pimozide 26120:Perazine 26095:Moperone 26085:Loxapine 25795:OSU-6162 25780:Ketamine 25710:A-412997 25558:Ciladopa 25553:2-OH-NPA 25527:Lisuride 25429:Agonists 25393:Odapipam 25378:Ecopipam 25362:Zotepine 25226:Loxapine 24959:Lisuride 24954:LEK-8829 24923:Trepipam 24888:6-Br-APB 24877:Agonists 24646:Serenics 24311:Vaccines 24078:Fibrates 23900:Vitamins 23850:Antacids 23677:Zotepine 23537:Atypical 23507:Loxapine 23456:Tiapride 23413:Disputed 23256:Perazine 23181:Pimozide 23138:Moperone 22971:23983951 22908:17035647 22873:21954480 22830:Archived 22828:. NICE. 22798:22376048 22752:1 August 22746:Archived 22712:42099598 22704:23235663 22661:22132426 22644:23168825 22601:17158480 22536:Archived 22481:15278977 22274:32943849 22199:23391323 22123:Archived 22107:17158480 21921:31271339 21882:Archived 21816:9 August 21765:22035718 21391:28141135 21348:33802262 21340:11510628 21297:18227146 21261:10511917 21226:36697288 21183:12623938 21175:23417765 21139:Archived 21117:Archived 21093:Archived 21065:Archived 21056:Medscape 21037:24062697 20986:12893717 20978:20404009 20942:17662268 20895:18308814 20822:11543666 20814:23812802 20768:31632038 20717:27525148 20666:21154393 20635:21733231 20581:22000157 20546:19638254 20495:23723707 20444:25512763 20436:21851976 20374:14974020 20325:23618581 20317:12152801 20282:17636691 20233:24729184 20224:11195628 20188:24194433 20157:25749632 20070:11463136 20035:24425538 20026:11015532 19962:22566771 19903:21277745 19867:17943763 19818:29893410 19743:23766647 19689:23464075 19681:20030420 19633:20531221 19432:Archived 19392:24825770 19383:11023599 19347:24425538 19338:11015532 19302:40524276 19221:Archived 19155:Archived 19133:10340686 19068:Archived 19024:: 236s. 18973:15492772 18924:22340010 18916:16126373 18881:Archived 18691:Archived 18661:Archived 18585:16082416 18442:Archived 18320:20942998 18269:34512264 18218:27371498 18169:23129329 18125:Archived 18016:12683259 17978:24877454 17970:22300864 17890:15257633 17830:14686220 17783:26738197 17775:16381088 17732:11463136 17661:22 March 17623:17650054 17596:10739327 17561:28925317 17491:16774655 17389:22952071 17340:32415541 17291:30568606 17240:27583123 17191:27144021 17140:14609248 17095:18385207 17038:15756305 16997:22910680 16956:23168990 16907:36059215 16858:16135861 16817:43114395 16809:16041235 16774:Archived 16723:22376048 16674:16449697 16625:19524406 16590:39945446 16582:14524644 16543:22438946 16503:PLOS ONE 16452:30384727 16444:19840894 16405:27314943 16397:12126218 16340:16001097 16299:38827016 16290:11141220 16248:21284696 16199:20187598 16172:41487184 16164:28464773 16129:17626963 16072:26364648 16037:27732102 15994:36066404 15958:51608744 15950:29985823 15904:28152356 15869:30767710 15820:29796248 15768:Archived 15737:30192088 15688:29325237 15645:28925317 15610:23870705 15564:14965234 15527:Archived 15470:Archived 15429:46530288 15421:20098227 15386:31807817 15378:10190226 15335:18515977 15266:22936056 15223:18332660 15188:18451005 15131:22499842 15123:16172203 15074:16449469 15038:19160174 14989:27270415 14981:11198061 14946:17619525 14905:23870705 14864:20954430 14815:31476766 14774:45484062 14766:23539465 14730:34448894 14722:19460067 14679:36638816 14554:Archived 14524:21464191 14489:22397999 14440:21550212 14405:35264346 14375:BMJ Open 14280:35843245 14221:33417992 14180:31860457 14123:22510671 14088:22973576 14062:22784311 14053:10438344 14008:22448598 13961:37941354 13952:10960313 13902:28755801 13845:37932158 13785:Archived 13751:23554581 13700:21154393 13666:37650479 13657:10471006 13617:16437455 13608:11365591 13569:20 April 13563:Archived 13531:21191528 13476:20704054 13449:15000267 13414:19160237 13383:22054050 13347:19200370 13296:20932562 13288:15994710 13252:18728771 13201:23485111 13158:Archived 13154:Medscape 13135:73471270 13127:30845817 13061:20402706 12997:19880919 12942:30466208 12882:18794651 12847:29621900 12795:32840872 12735:18616969 12700:32085212 12692:23810019 12639:18180760 12598:31974576 12549:26338693 12500:29179576 12456:29856558 12405:7 August 12399:Archived 12381:10416727 12340:25372935 12299:22893011 12255:22584864 12214:40089561 12206:21292923 12140:Archived 12115:24744675 12107:25689246 12072:29649948 12023:24378317 12015:25034359 11972:Archived 11909:23089129 11865:19058842 11821:12066446 11765:19909227 11713:49602956 11705:29953902 11670:10579370 11600:33637835 11548:23522488 11540:20085668 11502:21300943 11442:26388529 11404:25957394 11355:35093701 11271:Archived 11201:See also 11155:Seroquel 11115:Omnicare 10930:and the 10909:hypnotic 10901:neuroses 10795:lobotomy 10749:Sources: 10745:DrugBank 10679:Viscoleo 10655:1–2 days 10645:Viscoleo 10603:Atypical 10550:8.5–11.6 10534:Viscoleo 10439:8.1–10.1 10418:Atypical 10379:Meclopin 10346:Atypical 10169:Viscoleo 10132:Viscoleo 10053:Atypical 10037:7.9–10.0 10016:Atypical 10012:Aristada 9996:multiple 9845:Zotepine 9827:Oral, IM 9655:8 h 9560:receptor 9437:Pimozide 9337:2 h 9230:Oral, IM 9098:Loxapine 8409:Zotepine 7833:196 (RC) 7830:148 (RC) 7807:800 (HB) 7756:Pimozide 7485:150 (HB) 7482:180 (HB) 7479:578 (HB) 7355:2.0 (RC) 7280:Loxapine 7168:2,066.83 6819:206 (RC) 6703:530 (RC) 6349:Zotepine 6149:Loxapine 5809:Zotepine 5367:receptor 5170:Pimozide 4996:Perazine 4777:receptor 4662:Loxapine 4133:receptor 3907:Sedation 3867:Lundbeck 3843:Fujisawa 3837:Zoleptil 3834:Atypical 3827:Zotepine 3810:Atypical 3786:Disputed 3690:Disputed 3683:Tiapride 3675:Novartis 3669:Melleril 3645:Barnetil 3642:Disputed 3621:Dogmatil 3618:Disputed 3579:Lundbeck 3570:Atypical 3546:Atypical 3522:Disputed 3501:Seroquel 3498:Atypical 3429:Piportil 3402:Disputed 3371:Pimozide 3357:Nuplazid 3354:Atypical 3333:Trilafon 3306:Atypical 3267:Promonta 3251:Perazine 3210:Atypical 3186:Atypical 3162:Atypical 3138:Disputed 3114:Disputed 3090:Disputed 3069:Serentil 3051:Lundbeck 3042:Disputed 3018:Atypical 2994:Disputed 2987:Loxapine 2970:Disputed 2946:Disputed 2931:Novartis 2922:Atypical 2853:Prolixin 2835:Lundbeck 2829:Fluanxol 2778:Disputed 2757:Clozaril 2754:Atypical 2730:Disputed 2709:Clotepin 2706:Disputed 2691:Lundbeck 2658:Disputed 2634:Disputed 2586:Disputed 2562:Atypical 2541:Impromem 2514:Atypical 2490:Atypical 2442:Atypical 2427:Alkermes 2421:Aristada 2418:Atypical 2394:Atypical 2370:Disputed 2179:dopamine 2138:and 5-HT 2072:receptor 2068:and 5HT- 2057:receptor 1995:Zotepine 1733:Loxapine 1562:Perazine 1502:Pimozide 1458:Moperone 1454:(Haldol) 1293:dementia 1267:Loss of 1258:dementia 1215:Seizures 1042:Dystonia 1023:Diarrhea 943:seizures 805:delirium 719:insomnia 642:dementia 638:dementia 620:Dementia 565:such as 389:insomnia 385:dementia 251:such as 222:pallidal 194:paranoia 96:Dementia 74:Synonyms 60:atypical 27403:History 27316:Lithium 26644:F-15063 26482:AS-8112 26271:BL-1020 26100:Naranol 25870:RDS-127 25720:ABT-724 25715:ABT-670 25684:F-15063 25633:XP21279 25086:A-68930 25075:XP21279 25021:BCO-001 24985:A-86929 24980:A-77636 24503:General 24410:muscles 24379:L03–L04 24375:disease 24327:L01–L02 24323:disease 24073:Statins 23684:Others: 23524:Others: 23271:BL-1020 23090:Typical 22962:3736929 22916:5861676 22789:3571677 22695:6492452 22635:3711645 22376:Reuters 22265:7468370 22190:3575309 21694:7185768 21659:3545764 21624:4992598 21572:1429660 21529:6143748 21484:6931472 21383:7418717 21218:7140807 21028:3770982 21011:: 102. 20840:"PDSP K 20836:Roth BL 20759:6790347 20708:4976188 20589:8067809 20486:3665578 20365:7003674 20273:6718212 20148:7173727 19953:3330679 19936:: 1–5. 19911:8805912 19858:7017975 19809:3796096 19734:3677929 19294:4604881 18964:6741725 18848:5576292 18260:8427050 18209:4944179 18051:7791509 17935:1970851 17569:1957881 17499:6267180 17380:3516138 17331:7847435 17282:6290646 17265:: 622. 17231:4994396 17182:4842070 17086:2728806 16947:3565772 16898:9483823 16883:: e61. 16714:3571677 16633:8143217 16534:3306411 16511:Bibcode 16239:3045546 16120:1914490 15912:5388097 15860:6563116 15811:5956953 15728:6127753 15653:1957881 15601:3385413 15343:2669203 15179:5033643 15082:3849348 15029:7065592 14896:3385413 14855:3085113 14560:29 July 14532:2903864 14448:1254352 14396:8968526 14171:7029416 14131:9888209 13742:3595214 13522:3010964 13481:9 March 13338:2644292 13243:2515925 12933:6245299 12786:9702459 12589:7177160 12540:4601722 12447:5980504 12063:5900810 11873:1071537 11756:2958217 11591:8209146 11493:3476840 11302:1102277 11135:Zyprexa 11068:misused 10961:synonym 10907:and/or 10883:lambanō 10879:λαμβάνω 10877:) and " 10761:History 10741:PubChem 10705:All by 10695:7.5–9.0 10674:Typical 10658:4.7–4.9 10640:Typical 10566:Typical 10529:Typical 10513:6.4–7.2 10492:Typical 10455:Typical 10402:8.5–8.7 10383:Typical 10330:7.2–7.9 10312:Typical 10296:5.2–5.8 10275:Typical 10259:6.4–7.4 10238:Typical 10222:7.2–9.0 10201:Typical 10185:7.2–9.2 10164:Typical 10160:Depixol 10127:Typical 10090:Typical 10074:4.9–5.2 9973:Vehicle 9652:27 ± 9% 8011:2057.17 7928:1631.5 7824:15 (HC) 7334:211.33 7109:1,039.9 6866:2,115.5 6594:1,173.5 5950:Legend: 5931:EPSE – 5216:typical 4552:typical 4483:typical 4289:typical 4092:mostly) 3903:effects 3858:Typical 3765:Vesprin 3762:Typical 3738:Typical 3714:Typical 3666:Typical 3594:Typical 3555:Janssen 3477:Sparine 3474:Typical 3450:Typical 3426:Typical 3411:Janssen 3387:Janssen 3378:Typical 3330:Typical 3282:Typical 3261:Taxilan 3258:Typical 3243:Janssen 3234:Typical 3165:Zyprexa 3066:Typical 3045:Buronil 2907:Janssen 2898:Typical 2883:Janssen 2874:Typical 2850:Typical 2826:Typical 2802:Typical 2787:Aventis 2781:Tercian 2733:Etumine 2682:Typical 2610:Typical 2547:Janssen 2538:Typical 2517:Rexulti 2493:Lonasen 2475:Janssen 2466:Typical 2397:Abilify 2214:alleles 2192:of the 2188:in the 2144:2A/2B/7 1966:Symbyax 1113:tardive 1026:Anxiety 997:By rate 945:, NMS, 797:placebo 782:England 602:lithium 567:lithium 436:by the 317:λαμβάνω 145:D014150 27296:Other 26784:UH-232 26764:SV-293 26600:Others 25750:BP-897 25701:Others 25481:UH-232 25369:Others 25082:Others 24810: 24789: 24737:other 24668:system 24420:joints 24373:immune 24180:system 24140:system 23981:system 23753:WHO-EM 23706:Others 23038: 22969: 22959: 22914: 22906: 22871: 22796: 22786: 22710: 22702: 22692: 22659: 22642: 22632: 22599: 22568: 22479: 22272: 22262: 22197: 22187: 22105: 22053: 22027: 22003: 21979: 21950: 21927: 21919: 21874: 21847: 21812:. 1989 21763: 21692: 21657: 21622: 21581:444352 21579: 21569: 21527: 21482: 21389: 21381: 21346: 21338: 21303: 21295: 21259: 21224: 21216: 21181: 21173: 21035: 21025: 20984: 20976: 20940: 20901: 20893: 20820: 20812: 20766: 20756: 20715: 20705: 20664: 20633: 20587: 20579: 20544: 20493: 20483: 20442: 20434: 20416:Lancet 20372: 20362: 20323: 20315: 20280: 20270: 20231: 20221: 20186: 20155: 20145: 20076: 20068: 20033: 20023: 19960: 19950: 19909: 19901: 19865: 19855: 19816: 19806: 19741: 19731: 19687: 19679: 19639: 19631: 19594: 19569: 19544: 19517: 19490: 19463: 19390: 19380: 19345: 19335: 19300: 19292: 19255: 19131: 19102: 19044: 19036: 18996: 18971: 18961: 18922: 18914: 18873: 18846: 18819: 18782: 18752: 18725: 18583: 18497: 18465: 18434: 18318: 18267: 18257: 18216: 18206: 18167: 18157: 18090: 18049: 18014: 17976: 17968: 17933: 17923: 17888: 17828: 17820: 17781: 17773: 17738: 17730: 17621: 17594: 17567: 17559: 17522: 17497: 17489: 17449: 17410: 17387: 17377: 17338: 17328: 17289: 17279: 17238: 17228: 17189: 17179: 17138: 17120: 17093: 17083: 17044: 17036: 16995: 16954: 16944: 16905: 16895: 16856: 16815: 16807: 16721: 16711: 16672: 16631: 16623: 16588: 16580: 16541: 16531: 16480: 16450: 16442: 16403: 16395: 16338: 16331:487008 16328: 16297: 16287: 16246: 16236: 16197: 16170: 16162: 16127: 16117: 16078: 16070: 16035: 16000: 15992: 15956: 15948: 15910: 15902: 15867: 15857: 15818: 15808: 15760: 15735: 15725: 15686: 15651: 15643: 15608: 15598: 15562: 15501: 15427: 15419: 15384: 15376: 15341: 15333: 15264: 15229: 15221: 15186: 15176: 15168: 15129: 15121: 15080: 15072: 15036: 15026: 14987: 14979: 14944: 14934: 14903: 14893: 14862: 14852: 14813: 14772: 14764: 14728: 14720: 14685: 14677: 14636: 14530: 14522: 14487: 14446: 14438: 14403: 14393: 14354: 14320:5 June 14311: 14286: 14278: 14248:Lancet 14227: 14219: 14178: 14168: 14129: 14121: 14086: 14060: 14050: 14006: 13998: 13959: 13949: 13941: 13900: 13892: 13843: 13835: 13794:31 May 13749: 13739: 13698: 13664: 13654: 13615: 13605: 13529: 13519: 13474: 13447: 13420: 13412: 13381: 13345: 13335: 13294: 13286: 13250: 13240: 13199: 13133: 13125: 13059: 13021: 12995: 12940: 12930: 12890:203910 12888: 12880: 12845: 12801: 12793: 12783: 12741: 12733: 12698: 12690: 12672:Lancet 12637: 12596: 12586: 12547: 12537: 12498: 12454: 12444: 12379: 12338: 12297: 12253: 12212: 12204: 12113: 12105: 12070: 12060: 12021: 12013: 11941: 11907: 11871: 11863: 11845:Lancet 11819: 11812:161646 11809: 11763: 11753: 11711: 11703: 11668: 11598: 11588: 11546: 11538: 11500: 11490: 11448: 11440: 11422:Lancet 11402: 11361: 11353: 11300: 11263: 11147:Geodon 11143:Pfizer 11139:Bextra 11072:abused 10875:nerves 10867:neuron 10861:νεῦρον 9989:single 9976:Dosage 9917:CYP2D6 9878:CYP3A4 9874:CYP1A2 9861:31–240 9835:CYP1A2 9831:CYP3A4 9755:CYP1A2 9716:CYP2D6 9638:CYP2D6 9616:3 days 9597:CYP2D6 9546:CYP3A4 9470:CYP2D6 9466:CYP3A4 9441:40–50% 9427:CYP2D6 9314:CYP2D6 9310:CYP3A4 9271:CYP1A2 9261:1000 L 9177:CYP3A4 9167:6173 L 9135:CYP2D6 9131:CYP3A4 9127:CYP1A2 9086:IM, IV 9051:CYP2D6 9047:CYP3A4 9008:CYP3A4 8850:CYP3A4 8846:CYP2D6 8842:CYP1A2 8817:50–60% 8803:CYP2D6 8792:Oral, 8777:92–97% 8757:CYP3A4 8718:CYP2D6 8714:UGT1A4 8710:CYP1A2 8671:CYP3A4 8667:CYP2D6 8659:Oral, 8583:Routes 8506: 8395:0.1678 8345:1,001 8247:245.47 8244:1355.5 8197:134.15 8179:144.35 8109:2,692 8041:0.0476 8029:243.53 8002:422.88 7889:948.75 7810:1,955 7751:1,848 7633:56.33 7565:628.83 7397:1,000 7388:0.0240 7331:119.45 7254:129.32 7157:1,441 6973:19.25 6964:0.0341 6799:N-DEBN 6674:8,128 6665:0.0462 6615:4,678 6591:2091.5 6547:3774.5 6235:+++/++ 6215:+++/++ 6152:+++/++ 5969: 5841:+++/++ 5838:+++/++ 5591:+++/++ 4004:+++/++ 3819:Pfizer 3813:Geodon 3789:Agreal 3723:Pfizer 3717:Navane 3525:Roxiam 3309:Lullan 3189:Invega 3117:Cremin 3099:Abbott 3021:Latuda 2979:Abbott 2925:Fanapt 2901:Haldol 2637:Truxal 2469:Anquil 2373:Solian 2351:Launch 2006:Others 1846:, and 1744:Others 1394:Notes: 1231:Stroke 972:, and 949:, and 864:, and 703:autism 592:, and 488:ICD-11 313:) and 311:neuron 305:νεῦρον 259:, and 27253:SSRIs 26964:Mania 26604:3-PPP 25705:3-PPP 25421:-like 24869:-like 24791:Drugs 24508:Local 24475:brain 24414:bones 23915:blood 22912:S2CID 22708:S2CID 21925:S2CID 21639:Drugs 21387:S2CID 21344:S2CID 21305:41656 21301:S2CID 21222:S2CID 21179:S2CID 21061:WebMD 20982:S2CID 20899:S2CID 20818:S2CID 20585:S2CID 20440:S2CID 20321:S2CID 20074:S2CID 19907:S2CID 19685:S2CID 19637:S2CID 19298:S2CID 19161:7 May 19042:S2CID 18920:S2CID 18697:7 May 18128:(PDF) 18113:(PDF) 17974:S2CID 17870:Drugs 17779:S2CID 17736:S2CID 17682:Focus 17565:S2CID 17495:S2CID 17042:S2CID 16813:S2CID 16629:S2CID 16586:S2CID 16448:S2CID 16401:S2CID 16168:S2CID 16076:S2CID 15998:S2CID 15954:S2CID 15908:S2CID 15674:(1). 15649:S2CID 15425:S2CID 15382:S2CID 15339:S2CID 15231:34935 15227:S2CID 15127:S2CID 15078:S2CID 14985:S2CID 14770:S2CID 14726:S2CID 14683:S2CID 14634:S2CID 14528:S2CID 14444:S2CID 14352:S2CID 14284:S2CID 14225:S2CID 14127:S2CID 13788:(PDF) 13777:(PDF) 13418:S2CID 13321:: 4. 13292:S2CID 13131:S2CID 12886:S2CID 12799:S2CID 12739:S2CID 12696:S2CID 12210:S2CID 12111:S2CID 12019:S2CID 11995:Drugs 11869:S2CID 11709:S2CID 11544:S2CID 11446:S2CID 11359:S2CID 11218:Notes 11012:Legal 10986:Sales 10871:sinew 10855:Greek 10752:Main: 10735:with 10703:Note: 10423:Water 10351:Water 10280:Water 10058:Water 10021:Water 9970:Class 9921:None 9849:7–13% 9839:None 9796:None 9759:None 9720:None 9681:None 9642:None 9619:99.5% 9484:12.5% 9474:None 9459:Urine 9392:None 9346:Urine 9318:None 9275:None 9236:None 9152:9–19% 9108:96.6% 9012:None 8973:None 8936:None 8927:Urine 8899:None 8789:Urine 8722:None 8628:None 8454:0.108 8415:470.5 8398:62.67 8365:60.95 8356:54.67 8336:66.07 8318:391.5 8315:653.7 8309:290.8 8277:416.7 8259:51.95 8256:79.95 8250:15.25 8238:410.2 8235:3,878 8218:12.58 8188:57.05 8182:27.67 8176:1,259 8100:0.166 8044:20.05 7982:0.245 7916:2,019 7907:994.5 7901:28.85 7898:3,630 7892:307.6 7886:1,843 7880:394.2 7804:692.2 7801:33.34 7783:376.5 7780:1,593 7777:197.7 7768:2,112 7765:48.35 7748:1,500 7721:810.5 7683:1.104 7671:41.04 7662:17.35 7653:2,414 7644:616.6 7641:3,717 7624:0.109 7621:14.33 7615:34.23 7612:70.33 7597:105.2 7582:3,676 7568:2,130 7562:2,950 7547:172.6 7544:1,097 7541:2,612 7538:3,053 7535:1,008 7526:3,797 7506:1.186 7394:1,000 7361:40.21 7325:0.236 7319:19.33 7310:5,698 7304:150.9 7292:13.25 7286:2,456 7272:4,898 7266:0.179 7263:13.75 7260:10.55 7257:10.86 7236:63.09 7227:93.21 7195:121.8 7192:2,112 7186:801.5 7180:377.6 7177:5,133 7174:4,801 7171:56.81 7165:3,256 7154:1,095 7151:14.15 7148:126.4 7136:17.33 7133:3,076 7127:314.1 7118:34.67 7115:982.5 7112:37.93 7106:5,950 7050:8,028 7036:95.7 7027:0.115 7024:63.94 7012:493.9 7009:117.7 7006:137.6 7003:104.8 6985:316.6 6958:269.1 6952:266.3 6949:3,168 6937:17.95 6925:123.7 6922:1,624 6914:57.0 6890:2,443 6863:1,296 6834:1,020 6783:1.567 6718:0.494 6715:0.142 6712:1,070 6688:0.812 6671:8,128 6612:6,778 6609:27.93 6588:37.63 6582:25.85 6576:642.4 6564:1,081 6544:2,370 6529:1,540 6526:1,114 6517:4,154 6511:8,304 5995:Mania 5925:CI – 5919:OR – 5913:AE – 5369:in a 4974:−0.18 4755:−0.21 4750:−0.10 4184:−0.04 4109:−0.13 3894:rate 3603:Eisai 3483:Wyeth 3237:Semap 3171:Lilly 3093:Moban 3003:Wyeth 2715:Spofa 2643:Roche 2357:Refs 2342:Class 2194:brain 2136:2/3/4 2134:– A D 1954:manic 1254:death 982:ileus 680:Other 484:DSM-5 402:, an 299:Greek 26639:EEDQ 25383:EEDQ 25171:DPTQ 25166:DETQ 25155:PAMs 24418:and 24095:skin 23081:N05A 23036:ISBN 22992:2012 22967:PMID 22904:PMID 22869:PMID 22851:JAMA 22838:2013 22820:NICE 22812:link 22794:PMID 22754:2013 22700:PMID 22657:PMID 22640:PMID 22614:JAMA 22597:PMID 22566:ISBN 22544:2013 22495:link 22477:PMID 22270:PMID 22195:PMID 22148:2022 22103:PMID 22051:ISBN 22025:ISBN 22001:ISBN 21977:ISBN 21948:ISBN 21917:PMID 21872:ISBN 21845:ISBN 21818:2011 21777:2017 21761:PMID 21690:PMID 21655:PMID 21620:PMID 21577:PMID 21525:PMID 21480:PMID 21379:PMID 21336:PMID 21293:PMID 21257:PMID 21214:PMID 21171:PMID 21033:PMID 20974:PMID 20938:PMID 20891:PMID 20860:2013 20810:PMID 20764:PMID 20713:PMID 20689:2016 20662:PMID 20631:PMID 20577:PMID 20542:PMID 20491:PMID 20432:PMID 20400:2013 20370:PMID 20348:2004 20313:PMID 20278:PMID 20256:2007 20229:PMID 20184:PMID 20153:PMID 20131:2015 20108:2013 20066:PMID 20031:PMID 19990:2013 19958:PMID 19934:2012 19899:PMID 19863:PMID 19841:2007 19814:PMID 19792:2020 19769:2013 19739:PMID 19677:PMID 19629:PMID 19592:ISBN 19567:ISBN 19542:ISBN 19515:ISBN 19488:ISBN 19461:ISBN 19440:2017 19388:PMID 19343:PMID 19290:PMID 19253:ISBN 19229:2017 19163:2017 19129:PMID 19100:ISBN 19076:2017 19034:ISSN 18994:ISBN 18969:PMID 18912:PMID 18871:ISBN 18844:PMID 18817:ISSN 18780:ISBN 18750:ISBN 18723:ISBN 18699:2017 18669:2017 18581:PMID 18495:ISBN 18463:ISBN 18432:ISBN 18316:PMID 18265:PMID 18214:PMID 18165:PMID 18155:ISBN 18088:ISSN 18047:PMID 18012:PMID 17966:PMID 17931:PMID 17921:ISBN 17886:PMID 17855:2022 17826:PMID 17818:ISSN 17771:PMID 17728:PMID 17663:2020 17619:PMID 17592:PMID 17557:PMID 17520:ISBN 17487:PMID 17447:ISBN 17408:ISBN 17385:PMID 17336:PMID 17287:PMID 17236:PMID 17187:PMID 17163:2016 17136:PMID 17091:PMID 17034:PMID 16993:PMID 16952:PMID 16903:PMID 16854:PMID 16805:PMID 16737:link 16719:PMID 16670:PMID 16621:PMID 16578:PMID 16539:PMID 16478:ISBN 16440:PMID 16393:PMID 16336:PMID 16295:PMID 16244:PMID 16195:PMID 16160:PMID 16125:PMID 16068:PMID 16033:PMID 15990:PMID 15946:PMID 15900:PMID 15865:PMID 15816:PMID 15758:ISBN 15733:PMID 15684:PMID 15641:PMID 15606:PMID 15592:2012 15560:PMID 15535:2013 15499:ISBN 15478:2013 15417:PMID 15374:PMID 15331:PMID 15262:PMID 15219:PMID 15184:PMID 15166:ISSN 15119:PMID 15070:PMID 15034:PMID 15012:2009 14977:PMID 14942:PMID 14901:PMID 14887:2012 14860:PMID 14811:PMID 14762:PMID 14718:PMID 14675:PMID 14562:2013 14520:PMID 14485:PMID 14436:PMID 14401:PMID 14322:2013 14309:ISBN 14276:PMID 14217:PMID 14176:PMID 14119:PMID 14084:PMID 14058:PMID 14004:PMID 13996:ISSN 13957:PMID 13939:ISSN 13898:PMID 13890:ISSN 13841:PMID 13833:ISSN 13796:2020 13747:PMID 13696:PMID 13662:PMID 13640:2023 13613:PMID 13571:2015 13527:PMID 13483:2021 13472:PMID 13445:PMID 13410:PMID 13379:PMID 13343:PMID 13284:PMID 13248:PMID 13197:PMID 13166:2013 13123:PMID 13086:2022 13057:PMID 13019:ISBN 12993:PMID 12938:PMID 12878:PMID 12843:PMID 12791:PMID 12769:2020 12731:PMID 12688:PMID 12635:PMID 12594:PMID 12545:PMID 12496:PMID 12452:PMID 12407:2014 12377:PMID 12336:PMID 12295:PMID 12251:PMID 12202:PMID 12103:PMID 12068:PMID 12011:PMID 11980:2013 11939:ISBN 11905:PMID 11861:PMID 11817:PMID 11761:PMID 11701:PMID 11666:PMID 11616:and 11596:PMID 11536:PMID 11498:PMID 11438:PMID 11400:PMID 11351:PMID 11298:PMID 11261:ISBN 10963:for 10915:and 10824:and 10743:and 10002:Ref 9999:logP 9870:Oral 9790:Oral 9751:Oral 9712:Oral 9675:Oral 9634:Oral 9556:5-HT 9554:and 9542:Oral 9521:100% 9490:High 9462:Oral 9423:Oral 9386:Oral 9349:Oral 9198:(IM) 9173:Oral 9102:High 9043:Oral 8838:Oral 8753:Oral 8622:Oral 8534:Drug 8457:3.21 8392:52.9 8389:7.85 8386:4.35 8368:6.31 8359:0.73 8333:38.1 8327:1.12 8271:0.40 8268:0.12 8253:11.5 8224:12.8 8221:16.5 8215:6.00 8212:1.50 8209:2.20 8206:94.5 8200:74.9 8194:3.15 8153:8.05 8150:9.80 8097:4.92 8094:2.30 8091:2.35 8064:0.39 8038:4.66 8032:3.57 8020:16.5 8005:0.17 7922:6.90 7919:2.41 7860:23.1 7857:5.40 7854:2.90 7851:0.65 7795:0.25 7792:1.45 7736:0.13 7733:0.14 7724:85.2 7686:18.8 7680:54.3 7665:7.35 7647:0.71 7627:2.19 7618:47.0 7606:28.9 7594:8.07 7591:10.2 7588:3.73 7585:2282 7559:72.5 7529:3773 7500:8.95 7447:1.18 7429:10.8 7385:21.0 7382:21.0 7379:20.8 7328:4.90 7322:7.80 7316:28.1 7307:80.0 7301:31.0 7298:87.6 7295:31.0 7289:6.63 7251:1479 7248:16.2 7230:1.94 7210:1698 7207:81.2 7204:2.71 7201:3.96 7183:12.0 7145:40.0 7142:1.75 7139:0.30 7130:28.9 7124:6.45 7121:8.00 7092:0.86 7086:66.3 7083:1.75 7080:0.35 7033:67.6 7018:94.5 7015:14.3 7000:60.1 6997:11.6 6991:10.9 6988:13.9 6970:6.17 6967:1.13 6961:26.4 6940:1.62 6934:13.5 6931:9.44 6928:5.35 6911:32.3 6908:3.09 6905:3.21 6902:5.33 6899:4.65 6896:1.40 6893:76.3 6881:0.28 6878:28.4 6875:17.0 6872:15.6 6846:0.93 6840:0.23 6837:1.38 6816:5.03 6813:4.50 6810:1.28 6765:0.59 6747:0.47 6744:0.12 6724:5.72 6694:41.9 6691:26.4 6659:0.42 6638:0.13 6635:0.25 6632:0.03 6629:0.06 6600:5.35 6597:1.64 6585:74.1 6579:9.97 6573:22.4 6520:73.5 6472:5-HT 6421:5-HT 6415:5-HT 6409:5-HT 6403:5-HT 6397:5-HT 6394:SERT 6332:++/+ 6304:+++ 6104:+++ 6052:++/+ 6044:+++ 5823:1.07 5819:0.41 5814:0.69 5797:++/+ 5791:0.51 5787:0.31 5782:0.41 5758:0.86 5754:0.59 5749:0.72 5708:1.48 5704:0.59 5699:0.94 5676:++/+ 5617:1.40 5613:0.32 5608:0.67 5567:4.00 5563:0.25 5558:1.00 5535:1.02 5531:0.76 5526:0.90 5520:++/+ 5502:0.98 5498:0.61 5493:0.78 5470:0.36 5466:0.15 5461:0.25 5455:++/+ 5444:++/+ 5435:0.60 5431:0.46 5426:0.53 5349:0.29 5345:0.06 5340:0.17 5334:++/+ 5322:++/+ 5316:0.71 5312:0.52 5307:0.61 5184:3.39 5180:0.30 5175:1.01 5134:2.33 5130:0.04 5125:0.30 5108:++/+ 5096:++/+ 5010:1.10 5001:0.62 4978:0.26 4969:0.05 4955:++/+ 4943:0.58 4939:0.39 4934:0.48 4911:0.31 4907:0.11 4902:0.22 4878:0.52 4874:0.41 4869:0.46 4837:++/+ 4813:++/+ 4773:5-HT 4765:++/+ 4759:0.01 4738:++/+ 4726:0.96 4722:0.61 4717:0.77 4676:0.98 4672:0.28 4667:0.52 4638:++/+ 4613:++/+ 4607:0.46 4603:0.22 4598:0.34 4574:0.84 4570:0.56 4565:0.69 4538:0.19 4534:0.03 4529:0.11 4505:0.90 4501:0.71 4451:1.97 4447:0.24 4442:0.69 4353:and 4311:0.65 4307:0.32 4302:0.46 4257:0.84 4248:0.65 4231:++/+ 4219:++/+ 4210:~0.7 4188:0.65 4179:0.30 4176:++/+ 4155:0.86 4151:0.54 4146:0.69 4113:0.15 4104:0.01 4074:0.72 4070:0.51 4065:0.61 4051:++/+ 4048:++/+ 4045:++/+ 4042:++/+ 4039:++/+ 3998:0.91 3994:0.39 3989:0.66 3965:0.57 3961:0.32 3956:0.43 3912:EPSE 3864:1978 3840:1982 3816:2000 3792:1980 3768:1957 3744:1958 3720:1967 3696:1975 3672:1958 3648:1976 3624:1968 3600:1969 3576:1996 3552:1993 3528:1990 3504:1997 3480:1956 3456:1956 3432:1973 3408:1961 3384:1969 3381:Orap 3360:2016 3336:1957 3312:2001 3288:1964 3264:1958 3240:1973 3216:2009 3192:2007 3168:1996 3144:1991 3120:1991 3096:1975 3072:1967 3048:1967 3024:2010 3000:1975 2976:1987 2952:1957 2928:2010 2904:1959 2880:1970 2877:Imap 2856:1959 2832:1965 2808:1963 2784:1972 2760:1972 2736:1966 2712:1971 2688:1961 2664:1974 2640:1959 2616:1952 2592:1977 2568:2015 2544:1981 2520:2015 2496:2008 2472:1966 2448:2009 2424:2015 2400:2002 2376:1986 2345:Type 2305:MDMA 2283:5-HT 2281:and 2276:5-HT 2260:and 2206:5-HT 2173:and 1872:and 1811:and 1787:and 1779:and 1309:The 1159:5-HT 1128:most 1004:most 984:and 887:NICE 831:and 776:and 756:and 743:NICE 725:and 607:The 486:and 243:and 172:and 139:MeSH 25532:LSD 24739:ATC 24477:and 24236:and 22957:PMC 22949:doi 22894:doi 22890:355 22859:doi 22855:306 22784:PMC 22776:doi 22690:PMC 22682:doi 22630:PMC 22622:doi 22618:308 22589:doi 22558:doi 22469:doi 22260:PMC 22250:doi 22185:PMC 22175:doi 22095:doi 21909:doi 21837:doi 21753:doi 21682:doi 21647:doi 21567:PMC 21559:doi 21472:doi 21468:279 21414:doi 21371:doi 21328:doi 21285:doi 21249:doi 21206:doi 21163:doi 21023:PMC 21013:doi 20966:doi 20962:334 20930:doi 20926:572 20883:doi 20802:doi 20754:PMC 20744:doi 20703:PMC 20693:doi 20654:doi 20621:hdl 20613:doi 20569:doi 20532:hdl 20522:doi 20481:PMC 20471:doi 20424:doi 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