Knowledge

Dementia

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at risk for neuroleptic malignant syndrome, a life-threatening illness. Extreme caution is required in the use of antipsychotic medication in people with DLB because of their sensitivity to these agents. Antipsychotic drugs are used to treat dementia only if non-drug therapies have not worked, and the person's actions threaten themselves or others. Aggressive behavior changes are sometimes the result of other solvable problems, that could make treatment with antipsychotics unnecessary. Because people with dementia can be aggressive, resistant to their treatment, and otherwise disruptive, sometimes antipsychotic drugs are considered as a therapy in response. These drugs have risky adverse effects, including increasing the person's chance of stroke and death. Given these adverse events and small benefit antipsychotics are avoided whenever possible. Generally, stopping antipsychotics for people with dementia does not cause problems, even in those who have been on them a long time.
2751:, "In 2021, Alzheimer’s disease and other forms of dementia ranked as the seventh leading cause of death, killing 1.8 million lives." By 2050, the number of people living with dementia is estimated to be over 150 million globally. Around 7% of people over the age of 65 have dementia, with slightly higher rates (up to 10% of those over 65) in places with relatively high life expectancy. An estimated 58% of people with dementia are living in low and middle income countries. The prevalence of dementia differs in different world regions, ranging from 4.7% in Central Europe to 8.7% in North Africa/Middle East; the prevalence in other regions is estimated to be between 5.6 and 7.6%. The number of people living with dementia is estimated to double every 20 years. In 2016 dementia resulted in about 2.4 million deaths, up from 0.8 million in 1990. The genetic and environmental risk factors for dementia disorders vary by ethnicity. For instance, Alzheimer's disease among 1119:(language problems) as the main symptom. One type is called semantic variant primary progressive aphasia (SV-PPA). The main feature of this is the loss of the meaning of words. It may begin with difficulty naming things. The person eventually may lose the meaning of objects as well. For example, a drawing of a bird, dog, and an airplane in someone with FTD may all appear almost the same. In a classic test for this, a patient is shown a picture of a pyramid and below it a picture of both a palm tree and a pine tree. The person is asked to say which one goes best with the pyramid. In SV-PPA the person cannot answer that question. The other type is called non-fluent agrammatic variant primary progressive aphasia (NFA-PPA). This is mainly a problem with producing speech. They have trouble finding the right words, but mostly they have a difficulty coordinating the muscles they need to speak. Eventually, someone with NFA-PPA only uses one-syllable words or may become totally mute. 2571: 1516:. Physicians used to think that people with memory complaints had depression and not dementia (because they thought that those with dementia are generally unaware of their memory problems). However, researchers have realized that many older people with memory complaints in fact have mild cognitive impairment the earliest stage of dementia. Depression should always remain high on the list of possibilities, however, for an elderly person with memory trouble. Changes in thinking, hearing and vision are associated with normal ageing and can cause problems when diagnosing dementia due to the similarities. Given the challenging nature of predicting the onset of dementia and making a dementia diagnosis clinical decision making aids underpinned by machine learning and artificial intelligence have the potential to enhance clinical practice. 2886: 97: 2652: 3177: 2155:
or overstimulation can be helpful in reducing agitation. Additionally, using an "ABC analysis of behavior" can be a useful tool for understanding behavior in people with dementia. It involves looking at the antecedents (A), behavior (B), and consequences (C) associated with an event to help define the problem and prevent further incidents that may arise if the person's needs are misunderstood. The strongest evidence for non-pharmacological therapies for the management of changed behaviors in dementia is for using such approaches. Low quality evidence suggests that regular (at least five sessions of)
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These problems, however, are not severe enough to affect daily function. If and when they do, the diagnosis becomes dementia. The person may have some memory problems and trouble finding words, but they can solve everyday problems and competently handle their life affairs. During this stage, it is ideal to ensure that advance care planning has occurred to protect the person's wishes. Advance directives exist that are specific to sufferers of dementia; these can be particularly helpful in addressing the decisions related to feeding which come with the progression of the illness.
2904:, who divided the human lifespan into six distinct phases: 0–6 (infancy), 7–21 (adolescence), 22–49 (young adulthood), 50–62 (middle age), 63–79 (old age), and 80–death (advanced age). The last two he described as the "senium", a period of mental and physical decay, and that the final phase was when "the scene of mortal existence closes after a great length of time that very fortunately, few of the human species arrive at, where the mind is reduced to the imbecility of the first epoch of infancy". In 550 BC, the Athenian statesman and poet 2092:
person's distress and keeping the person safe. Treatments other than medication appear to be better for agitation and aggression. Cognitive and behavioral interventions may be appropriate. Some evidence suggests that education and support for the person with dementia, as well as caregivers and family members, improves outcomes. Palliative care interventions may lead to improvements in comfort in dying, but the evidence is low. Exercise programs are beneficial with respect to activities of daily living, and potentially improve dementia.
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seniors without dementia. Pain is often overlooked in older adults and, when screened for, is often poorly assessed, especially among those with dementia, since they become incapable of informing others of their pain. Beyond the issue of humane care, unrelieved pain has functional implications. Persistent pain can lead to decreased ambulation, depressed mood, sleep disturbances, impaired appetite, and exacerbation of cognitive impairment and pain-related interference with activity is a factor contributing to falls in the elderly.
1636:, which commonly occurs alongside dementia, score worse in the MoCA test, which could lead to a false diagnosis of dementia. Researchers have developed an adapted version of the MoCA test, which is accurate and reliable and avoids the need for people to listen and respond to questions. The AD-8 – a screening questionnaire used to assess changes in function related to cognitive decline – is potentially useful, but is not diagnostic, is variable, and has risk of bias. An 2226: 19018: 1493:. Delirium can be easily confused with dementia due to similar symptoms. Delirium is characterized by a sudden onset, fluctuating course, a short duration (often lasting from hours to weeks), and is primarily related to a somatic (or medical) disturbance. In comparison, dementia has typically a long, slow onset (except in the cases of a stroke or trauma), slow decline of mental functioning, as well as a longer trajectory (from months to years). 3055:
experienced no substantial cognitive impairment. Some evidence suggests that dementia is most likely to develop between ages 80 and 84 and individuals who pass that point without being affected have a lower chance of developing it. Women account for a larger percentage of dementia cases than men, although this can be attributed to their longer overall lifespan and greater odds of attaining an age where the condition is likely to occur.
2179:, and video biographies have been found to address the needs of clients and their caregivers in various ways, offering the client the opportunity to leave a legacy and enhance their personhood and also benefitting youth who participate in such work. Such interventions can be more beneficial when undertaken at a relatively early stage of dementia. They may also be problematic in those who have difficulties in processing past experiences 2812: 898: 1108:, and this can be detected in pre-dementia states. In bv-FTD, the person shows a change in personal hygiene, becomes rigid in their thinking, and rarely acknowledges problems; they are socially withdrawn, and often have a drastic increase in appetite. They may become socially inappropriate. For example, they may make inappropriate sexual comments, or may begin using pornography openly. One of the most common signs is 3002:. Deter had begun to behave uncharacteristically, including accusing her husband of adultery, neglecting household chores, exhibiting difficulties writing and engaging in conversations, heightened insomnia, and loss of directional sense. At one point, Deter was reported to have "dragged a bed sheet outside, wandered around wildly, and cried for hours at midnight." Alzheimer began treating Deter when she entered a 997:. The symptoms of this dementia depend on where in the brain the strokes occurred and whether the blood vessels affected were large or small. Repeated injury can cause progressive dementia over time, while a single injury located in an area critical for cognition such as the hippocampus, or thalamus, can lead to sudden cognitive decline. Elements of vascular dementia may be present in all other forms of dementia. 2794:
a decrease in modifiable risk factors made possible by greater financial and educational resources. It is one of the most common causes of disability among the elderly but can develop before the age of 65 when it is known as early-onset dementia or presenile dementia. Less than 1% of those with Alzheimer's have gene mutations that cause a much earlier development of the disease, around the age of 45, known as
3221:(Driver & Vehicle Licensing Agency) states that people with dementia who specifically have poor short-term memory, disorientation, or lack of insight or judgment are not allowed to drive, and in these instances the DVLA must be informed so that the driving license can be revoked. They acknowledge that in low-severity cases and those with an early diagnosis, drivers may be permitted to continue driving. 2798:. More than 95% of people with Alzheimer's disease have the sporadic form (late onset, 80–90 years of age). Worldwide the cost of dementia in 2015 was put at US$ 818 billion. People with dementia are often physically or chemically restrained to a greater degree than necessary, raising issues of human rights. Social stigma is commonly perceived by those with the condition, and also by their caregivers. 1752:, a potentially reversible cause of dementia, or connected tumor. The scans can also yield information relevant to other types of dementia, such as infarction (stroke) that would point at a vascular type of dementia. These tests do not pick up diffuse metabolic changes associated with dementia in a person who shows no gross neurological problems (such as paralysis or weakness) on a neurological exam. 775:(MMSE). MMSE scores are set at 24 to 30 for a normal cognitive rating and lower scores reflect severity of symptoms. The symptoms are dependent on the type of dementia. More complicated chores and tasks around the house or at work become more difficult. The person can usually still take care of themselves but may forget things like taking pills or doing laundry and may need prompting or reminders. 19006: 1608:(5–15 minutes) have reasonable reliability to screen for dementia, but may be affected by factors such as age, education and ethnicity. Age and education have a significant influence on the diagnosis of dementia. For example, Individuals with lower education are more likely to be diagnosed with dementia than their educated counterparts. While many tests have been studied, presently the 3067:. With significant increases in life expectancy thereafter, the number of people over 65 started rapidly climbing. While elderly persons constituted an average of 3–5% of the population prior to 1945, by 2010 many countries reached 10–14% and in Germany and Japan, this figure exceeded 20%. Public awareness of Alzheimer's Disease greatly increased in 1994 when former US president 19030: 2338:(MATCH-D) criteria can help identify ways that a diagnosis of dementia changes medication management for other health conditions. These criteria were developed because people with dementia live with an average of five other chronic diseases, which are often managed with medications. The systematic review that informed the criteria were published subsequently in 2018 and 1062:, not due to medication or stroke; and repeated visual hallucinations. The visual hallucinations in DLB are generally vivid hallucinations of people or animals and they often occur when someone is about to fall asleep or wake up. Other prominent symptoms include problems with planning (executive function) and difficulty with visual-spatial function, and disruption in 2288:
memantine. EGb 761 is the only one that showed improvement of symptoms in both AD and vascular dementia. EGb 761 is seen as being able to play an important role either on its own or as an add-on particularly when other therapies prove ineffective. EGb 761 is seen to be neuroprotective; it is a free radical scavenger, improves mitochondrial function, and modulates
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affects 5% of the population older than 65 and 20–40% of those older than 85. Rates are slightly higher in women than men at ages 65 and greater. The disease trajectory is varied and the median time from diagnosis to death depends strongly on age at diagnosis, from 6.7 years for people diagnosed aged 60–69 to 1.9 years for people diagnosed at 90 or older.
2540:. Because the decline can be rapid, and because most people prefer to allow the person with dementia to make their own decisions, palliative care involvement before the late stages of dementia is recommended. Further research is required to determine the appropriate palliative care interventions and how well they help people with advanced dementia. 1298:. Brain regions affected are similar to those that are affected by aging, and also by Alzheimer's disease. Regions showing loss of volume include the frontal, temporal, and parietal lobes, as well as the cerebellum, thalamus, and hippocampus. This loss can be more notable, with greater cognitive impairments seen in those aged 65 years and older. 2190:
the burden commonly placed on their caregivers. Occupational therapists can also work with other disciplines to create a client centered intervention. To manage cognitive disability, and coping with behavioral and psychological symptoms of dementia, combined occupational and behavioral therapies can support patients with dementia even further.
3027:, and atherosclerotic alteration. At the time, the consensus among medical doctors had been that senile plaques were generally found in older patients, and the occurrence of neurofibrillary tangles was an entirely new observation at the time. Alzheimer presented his findings at the 37th psychiatry conference of southwestern Germany in 3394:
considered to be the three major dementias." The NINDS (2020) says that Lewy body dementia "is one of the most common causes of dementia, after Alzheimer's disease and vascular disease." Hershey (2019) says, "DLB is the third most common of all the neurodegenerative diseases behind both Alzheimer's disease and Parkinson's disease".
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solving problems, and their social judgment is often impaired. They cannot usually function outside their own home, and generally should not be left alone. They may be able to do simple chores around the house but not much else, and begin to require assistance for personal care and hygiene beyond simple reminders. A
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A helpful finding was that although the incidence of Alzheimer's disease increased with age (from 5–10% of 75-year-olds to as many as 40–50% of 90-year-olds), no threshold was found by which age all persons developed it. This is shown by documented supercentenarians (people living to 110 or more) who
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and age-related cognitive decline had become more established. By the 1970s, the medical community maintained that vascular dementia was rarer than previously thought and Alzheimer's disease caused the vast majority of old age mental impairments. More recently however, it is believed that dementia is
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The immediate and long-term effects of modifying the thickness of fluids for swallowing difficulties in people with dementia are not well known. While thickening fluids may have an immediate positive effect on swallowing and improving oral intake, the long-term impact on the health of the person with
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As people age, they experience more health problems, and most health problems associated with aging carry a substantial burden of pain; therefore, between 25% and 50% of older adults experience persistent pain. Seniors with dementia experience the same prevalence of conditions likely to cause pain as
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Since dementia impairs normal communication due to changes in receptive and expressive language, as well as the ability to plan and problem solve, agitated behavior is often a form of communication for the person with dementia. Actively searching for a potential cause, such as pain, physical illness,
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Frontotemporal dementias (FTDs) are characterized by drastic personality changes and language difficulties. In all FTDs, the person has a relatively early social withdrawal and early lack of insight. Memory problems are not a main feature. There are six main types of FTD. The first has major symptoms
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affecting perception and orientation. The symptoms progress at a continuous rate over several stages, and they vary across the dementia subtypes. Most types of dementia are slowly progressive with some deterioration of the brain well established before signs of the disorder become apparent. There are
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Many countries consider the care of people living with dementia a national priority and invest in resources and education to better inform health and social service workers, unpaid caregivers, relatives and members of the wider community. Several countries have authored national plans or strategies.
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suggested a link between senile dementia and Alzheimer's disease. Katzmann suggested that much of the senile dementia occurring (by definition) after the age of 65, was pathologically identical with Alzheimer's disease occurring in people under age 65 and therefore should not be treated differently.
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About 3% of people between the ages of 65–74 have dementia, 19% between 75 and 84, and nearly half of those over 85 years of age. As more people are living longer, dementia is becoming more common. For people of a specific age, however, it may be becoming less frequent in the developed world, due to
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The annual incidence of dementia diagnosis is nearly 10 million worldwide. Almost half of new dementia cases occur in Asia, followed by Europe (25%), the Americas (18%) and Africa (8%). The incidence of dementia increases exponentially with age, doubling with every 6.3-year increase in age. Dementia
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Occupational therapy also addresses psychological and psychosocial needs of patients with dementia through improving daily occupational performance and caregivers' competence. When compensatory intervention strategies are added to their daily routine, the level of performance is enhanced and reduces
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established 'Singing for the Brain' (SftB) a project based on pilot studies which suggested that the activity encouraged participation and facilitated the learning of new songs. The sessions combine aspects of reminiscence therapy and music. Musical and interpersonal connectedness can underscore the
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Another approach to screening for dementia is to ask an informant (relative or other supporter) to fill out a questionnaire about the person's everyday cognitive functioning. Informant questionnaires provide complementary information to brief cognitive tests. Probably the best known questionnaire of
1612:(MMSE) is the best studied and most commonly used. The MMSE is a useful tool for helping to diagnose dementia if the results are interpreted along with an assessment of a person's personality, their ability to perform activities of daily living, and their behaviour. Other cognitive tests include the 947:
Little is known about the events that occur during and that actually cause Alzheimer's disease. This is due to the fact that brain tissue from patients with the disease can only be studied after the person's death. However, it is known that one of the first aspects of the disease is a dysfunction in
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Signs and symptoms at the prodromal stage may be subtle, and the early signs often become apparent only in hindsight. Of those diagnosed with MCI, 70% later progress to dementia. In MCI, changes in the person's brain have been happening for a long time, but the symptoms are just beginning to appear.
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The course of dementia is often described in four stages – pre-dementia, early, middle, and late, that show a pattern of progressive cognitive and functional impairment. More detailed descriptions can be arrived at by the use of numeric scales. These scales include the Global Deterioration Scale for
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Signs of dementia include getting lost in a familiar neighborhood, using unusual words to refer to familiar objects, forgetting the name of a close family member or friend, forgetting old memories, and being unable to complete tasks independently. People with developing dementia often fall behind on
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Some hospitals in Britain work to provide enriched and friendlier care. To make the hospital wards calmer and less overwhelming to residents, staff replaced the usual nurses' station with a collection of smaller desks, similar to a reception area. The incorporation of bright lighting helps increase
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for what is now understood as schizophrenia and senile dementia helped limit the word's meaning to "permanent, irreversible mental deterioration". This began the change to the later use of the term. In recent studies, researchers have seen a connection between those diagnosed with schizophrenia and
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mental hospital on November 25, 1901. During her ongoing treatment, Deter and her husband struggled to afford the cost of the medical care, and Alzheimer agreed to continue her treatment in exchange for Deter's medical records and donation of her brain upon death. Deter died on April 8, 1906, after
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Before prescribing antipsychotic medication in the elderly, an assessment for an underlying cause of the behavior is needed. Severe and life-threatening reactions occur in almost half of people with DLB, and can be fatal after a single dose. People with Lewy body dementias who take neuroleptics are
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discussed the mental decline that can come with old age and predicted that this affects everyone who becomes old and nothing can be done to stop this decline from taking place. Plato specifically talked about how the elderly should not be in positions that require responsibility because, "There is
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Benefits in those with advanced dementia has not been shown. The risks of using tube feeding include agitation, rejection by the person (pulling out the tube, or otherwise physical or chemical immobilization to prevent them from doing this), or developing pressure ulcers. The procedure is directly
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that may be possible to be reduced or eliminated. Managing these risk factors can reduce the risk of dementia in individuals in their late midlife or older age. A reduction in a number of these risk factors can give a positive outcome. The decreased risk achieved by adopting a healthy lifestyle is
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Diagnosis of mixed dementia can be difficult, as often only one type will predominate. This makes the treatment of people with mixed dementia uncommon, with many people missing out on potentially helpful treatments. Mixed dementia can mean that symptoms onset earlier, and worsen more quickly since
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Hadjistavropoulos T, Herr K, Turk DC, Fine PG, Dworkin RH, Helme R, Jackson K, Parmelee PA, Rudy TE, Lynn Beattie B, Chibnall JT, Craig KD, Ferrell B, Ferrell B, Fillingim RB, Gagliese L, Gallagher R, Gibson SJ, Harrison EL, Katz B, Keefe FJ, Lieber SJ, Lussier D, Schmader KE, Tait RC, Weiner DK,
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Credit scores among people who later develop dementia begin falling sharply long before their disease is formally identified. A year before diagnosis, these people were 17.2 percent more likely to be delinquent on their mortgage payments than before the onset of the disease, and 34.3 percent more
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Many support networks are available to people with dementia and their families and caregivers. Charitable organizations aim to raise awareness and campaign for the rights of people living with dementia. Support and guidance are available on assessing testamentary capacity in people with dementia.
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As of 2015, the annual cost per Alzheimer's patient in the United States was around $ 19,144.36. The total costs for the nation is estimated to be about $ 167.74 billion. By 2030, it is predicted the annual socioeconomic cost will total to about $ 507 billion, and by 2050 that number is
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Gray F, Adle-Biassette H, Chretien F, Lorin de la Grandmaison G, Force G, Keohane C (2001). "Neuropathology and neurodegeneration in human immunodeficiency virus infection. Pathogenesis of HIV-induced lesions of the brain, correlations with HIV-associated disorders and modifications according to
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The view that dementia must always be the result of a particular disease process led for a time to the proposed diagnosis of "senile dementia of the Alzheimer's type" (SDAT) in persons over the age of 65, with "Alzheimer's disease" diagnosed in persons younger than 65 who had the same pathology.
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Non-pharmacological approaches have been suggested for treating sleep problems for those with dementia, however, there is no strong evidence or firm conclusions on the effectiveness of different types of interventions, especially for those who are living in an institutionalized setting such as a
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has been widely used for treating mild to moderate dementia and other neuropsychiatric disorders. Its use is approved throughout Europe. The World Federation of Biological Psychiatry guidelines lists EGb 761 with the same weight of evidence (level B) given to acetylcholinesterase inhibitors, and
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The effect of therapies can be evaluated for example by assessing agitation using the Cohen-Mansfield Agitation Inventory (CMAI); by assessing mood and engagement with the Menorah Park Engagement Scale (MPES); and the Observed Emotion Rating Scale (OERS) or by assessing indicators for depression
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are more useful in assessing long-standing cognitive dysfunction, since they have shown similar ability to diagnose dementia as a clinical exam and cognitive testing. The ability of SPECT to differentiate vascular dementia from Alzheimer's disease, appears superior to differentiation by clinical
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More than one type of dementia, known as mixed dementia, may exist together in about 10% of dementia cases. The most common type of mixed dementia is Alzheimer's disease and vascular dementia. This particular type of mixed dementia's main onsets are a mixture of old age, high blood pressure, and
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As dementia progresses, initial symptoms generally worsen. The rate of decline is different for each person. MMSE scores between 6–17 signal moderate dementia. For example, people with moderate Alzheimer's dementia lose almost all new information. People with dementia may be severely impaired in
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held a view much more in line with modern-day medical wisdom that loss of mental function was not inevitable in the elderly and "affected only those old men who were weak-willed". He spoke of how those who remained mentally active and eager to learn new things could stave off dementia. However,
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Exercise programs may improve the ability of people with dementia to perform daily activities, but the best type of exercise is still unclear. Getting more exercise can slow the development of cognitive problems such as dementia, proving to reduce the risk of Alzheimer's disease by about 50%. A
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have no benefit in dementia. Medications for other health conditions may need to be managed differently for a person who has a dementia diagnosis. It is unclear whether blood pressure medication and dementia are linked. People may experience an increase in cardiovascular-related events if these
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Often overlooked in treating and managing dementia is the role of the caregiver and what is known about how they can support multiple interventions. Findings from a 2021 systematic review of the literature found caregivers of people with dementia in nursing homes do not have sufficient tools or
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which negatively affects cognition. Social isolation is also identified as a modifiable risk factor. Age-related hearing loss in midlife is linked to cognitive impairment in late life, and is seen as a risk factor for the development of Alzheimer's disease and dementia. Such hearing loss may be
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Clinical neuropsychologists provide diagnostic consultation following administration of a full battery of cognitive testing, often lasting several hours, to determine functional patterns of decline associated with varying types of dementia. Tests of memory, executive function, processing speed,
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implications for this vulnerable population. Health professionals often lack the skills and usually lack the time needed to recognize, accurately assess and adequately monitor pain in people with dementia. Family members and friends can make a valuable contribution to the care of a person with
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Diet is seen to be a modifiable risk factor for the development of dementia. Thiamine deficiency is identified to increase the risk of Alzheimer's disease in adults. The role of thiamine in brain physiology is unique and essential for the normal cognitive function of older people. Many dietary
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have been examined in the brains of Alzheimer's patients. Spirochetes are neurotropic in nature, meaning they act to destroy nerve tissue and create inflammation. Inflammatory pathogens are an indicator of Alzheimer's disease and bacteria related to gum disease have been found in the brains of
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administration, or in certain cases, the elimination of the causative agent. A 2019 review found no association between celiac disease and dementia overall but a potential association with vascular dementia. A 2018 review found a link between celiac disease or non-celiac gluten sensitivity and
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are often used early in the disorder course; however, benefit is generally small. More than half of people with dementia may experience psychological or behavioral symptoms including agitation, sleep problems, aggression, and/or psychosis. Treatment for these symptoms is aimed at reducing the
1395:. For Lyme disease and neurosyphilis, testing should be done if risk factors are present. Because risk factors are often difficult to determine, testing for neurosyphilis and Lyme disease, as well as other mentioned factors, may be undertaken as a matter of course where dementia is suspected. 3393:
Kosaka (2017) writes: "Dementia with Lewy bodies (DLB) is now well known to be the second most frequent dementia following Alzheimer disease (AD). Of all types of dementia, AD is known to account for about 50%, DLB about 20% and vascular dementia (VD) about 15%. Thus, AD, DLB, and VD are now
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Over 40% of people with dementia report sleep problems. Approaches to treating these sleep problems include medications and non-pharmacological approaches. The use of medications to alleviate sleep disturbances that people with dementia often experience has not been well researched, even for
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People with late-stage dementia typically turn increasingly inward and need assistance with most or all of their personal care. People with dementia in the late stages usually need 24-hour supervision to ensure their personal safety, and meeting of basic needs. If left unsupervised, they may
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effectively supports people with dementia to manage memory issues. Some of the specific things that are used today that helps with dementia today are: clocks, communication aids, electrical appliances the use monitoring, GPS location/ tracking devices, home care robots, in-home cameras, and
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Rodda J, Morgan S, Walker Z (October 2009). "Are cholinesterase inhibitors effective in the management of the behavioral and psychological symptoms of dementia in Alzheimer's disease? A systematic review of randomized, placebo-controlled trials of donepezil, rivastigmine and galantamine".
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were differentiated from Alzheimer's disease and vascular dementias (the most common types). This differentiation is on the basis of pathological examination of brain tissues, by symptomatology, and by different patterns of brain metabolic activity in nuclear medical imaging tests such as
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can be helpful to patients and their caregivers by helping people with the disorder and their caregivers understand what to expect, deal with loss of physical and mental abilities, support the person's wishes and goals including surrogate decision making, and discuss wishes for or against
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has been found to be helpful. Drawbacks may be that pets are not always welcomed in a communal space in the care setting. An animal may pose a risk to residents, or may be perceived to be dangerous. Certain animals may also be regarded as "unclean" or "dangerous" by some cultural groups.
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and dopamine levels. Many studies of its use in mild to moderate dementia have shown it to significantly improve cognitive function, activities of daily living, neuropsychiatric symptoms, and quality of life. However, its use has not been shown to prevent the progression of dementia.
1868:(ELSA), research found that loneliness in older people can increase the risk of dementia by one-third. Not having a partner (being single, divorced, or widowed) can double the risk of dementia. However, having two or three closer relationships might reduce the risk by three-fifths. 3158:, and thus (by definition) removed from possible causes of "dementing illnesses" (dementias). At the same, however, the traditional cause of senile dementia – "hardening of the arteries" – now returned as a set of dementias of vascular cause (small strokes). These were now termed 16470: 3261:
donated £1 million to dementia charities, after watching a former music teacher with dementia, Paul Harvey, playing one of his own compositions on the piano in a viral video. The donation was announced to be split between the Alzheimer's Society and Music for Dementia.
2240:, may be useful for Alzheimer's disease, Parkinson's disease dementia, DLB, or vascular dementia. The quality of the evidence is poor and the benefit is small. No difference has been shown between the agents in this family. In a minority of people side effects include a 2072:
supplements do not appear to benefit or harm people with mild to moderate symptoms. However, there is good evidence that omega-3 incorporation into the diet is of benefit in treating depression, a common symptom, and potentially modifiable risk factor for dementia.
1202:, and mostly affects younger people. The essential features of HIV-associated dementia are disabling cognitive impairment accompanied by motor dysfunction, speech problems and behavioral change. Cognitive impairment is characterised by mental slowness, trouble with 3192:
expected to reach $ 1.89 trillion. This steady increase will be seen not just within the United States but globally. Global estimates for the costs of dementia were $ 957.56 billion in 2015, but by 2050 the estimated global cost is $ 9.12 trillion.
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centers as well as special care units in nursing homes often provide specialized care for dementia patients. Daycare centers offer supervision, recreation, meals, and limited health care to participants, as well as providing respite for caregivers. In addition,
2135:, such as cognitive stimulation programs for people with mild to moderate dementia. Offering personally tailored activities may help reduce challenging behavior and may improve quality of life. It is not clear if personally tailored activities have an impact on 1840:, traumatic brain injury, and air pollution can also increase the chance of developing dementia. Many of these risk factors, including the lower level of education, smoking, physical inactivity and diabetes, are modifiable. Several of the group are known as 1677:
attention and language skills are relevant, as well as tests of emotional and psychological adjustment. These tests assist with ruling out other etiologies and determining relative cognitive decline over time or from estimates of prior cognitive abilities.
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Much like other diseases associated with aging, dementia was comparatively rare before the 20th century, because few people lived past 80. Conversely, syphilitic dementia was widespread in the developed world until it was largely eradicated by the use of
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Some London hospitals found that using color, designs, pictures and lights helped people with dementia adjust to being at the hospital. These adjustments to the layout of the dementia wings at these hospitals helped patients by preventing confusion.
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not much acumen of the mind that once carried them in their youth, those characteristics one would call judgement, imagination, power of reasoning, and memory. They see them gradually blunted by deterioration and can hardly fulfill their function."
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that makes the understanding of speech against background noise difficult. Age-related hearing loss is characterised by slowed central processing of auditory information. Worldwide, mid-life hearing loss may account for around 9% of dementia cases.
2043:. A study conducted at the University of Exeter in the United Kingdom seems to have confirmed these findings with fruits, vegetables, whole grains, and healthy fats creating an optimum diet that can help reduce the risk of dementia by roughly 25%. 1066:. Abnormal sleep behaviors may begin before cognitive decline is observed and are a core feature of DLB. RBD is diagnosed either by sleep study recording or, when sleep studies cannot be performed, by medical history and validated questionnaires. 2778:
A new 2024 study reveals that deaths from dementia in the U.S. have tripled in the past 21 years, rising from around 150,000 in 1999 to over 450,000 in 2020; the likelihood of dying from dementia increased across all demographic groups studied.
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Remotely delivered interventions including support, training and information may reduce the burden for the informal caregiver and improve their depressive symptoms. There is no certain evidence that they improve health-related quality of life.
674:(CDR). Using the GDS, which more accurately identifies each stage of the disease progression, a more detailed course is described in seven stages – two of which are broken down further into five and six degrees. Stage 7(f) is the final stage. 9592:
Carter CJ (February 2011). "Alzheimer's disease plaques and tangles: cemeteries of a pyrrhic victory of the immune defence network against herpes simplex infection at the expense of complement and inflammation-mediated neuronal destruction".
6547: 9252:
Fink HA, Jutkowitz E, McCarten JR, Hemmy LS, Butler M, Davila H, et al. (January 2018). "Pharmacologic Interventions to Prevent Cognitive Decline, Mild Cognitive Impairment, and Clinical Alzheimer-Type Dementia: A Systematic Review".
1667:. Evidence is insufficient to determine how accurate the IQCODE is for diagnosing or predicting dementia. The Alzheimer's Disease Caregiver Questionnaire is another tool. It is about 90% accurate for Alzheimer's when by a caregiver. The 9881:
Shannon OM, Ranson JM, Gregory S, Macpherson H, Milte C, Lentjes M, Mulligan A, McEvoy C, Griffiths A, Matu J, Hill TR, Adamson A, Siervo M, Minihane AM, Muniz-Tererra G, Ritchie C, Mathers JC, Llewellyn DJ, Stevenson E (March 2023).
7084:
Makhlouf S, Messelmani M, Zaouali J, Mrissa R (2018). "Cognitive impairment in celiac disease and non-celiac gluten sensitivity: review of literature on the main cognitive impairments, the imaging and the effect of gluten free diet".
545:. Although the greatest risk factor for developing dementia is aging, dementia is not a normal part of the aging process; many people aged 90 and above show no signs of dementia. Several risk factors for dementia, such as smoking and 2104:
residents living with dementia. A programme showed that such simple measures reduced residents' agitation and depression. They also needed fewer GP visits and hospital admissions, which also meant that the programme was cost-saving.
10196:
Watt JA, Goodarzi Z, Veroniki AA, Nincic V, Khan PA, Ghassemi M, et al. (November 2019). "Comparative Efficacy of Interventions for Aggressive and Agitated Behaviors in Dementia: A Systematic Review and Network Meta-analysis".
862:
is a cardinal feature of these. Other common causes include vascular dementia, dementia with Lewy bodies, frontotemporal dementia, and mixed dementia (commonly Alzheimer's disease and vascular dementia). Less common causes include
3187:
The societal cost of dementia is high, especially for caregivers. According to a UK-based study, almost two out of three carers of people with dementia feel lonely. Most of the carers in the study were family members or friends.
2046:
The MIND diet may be more protective but further studies are needed. The Mediterranean diet seems to be more protective against Alzheimer's than DASH but there are no consistent findings against dementia in general. The role of
2159:
may help institutionalized residents. It may reduce depressive symptoms and improve overall behaviors. It may also supply a beneficial effect on emotional well-being and quality of life, as well as reduce anxiety. In 2003, The
4999:
Bateman DR, Gill S, Hu S, Foster ED, Ruthirakuhan MT, Sellek AF, Mortby ME, Matušková V, Ng KP, Tarawneh RM, Freund-Levi Y, Kumar S, Gauthier S, Rosenberg PB, Ferreira de Oliveira F, Devanand DP, Ballard C, Ismail Z (2020).
1971:
and promoting the onset of Alzheimer's. Individuals with a plethora of tooth plaque risk cognitive decline. Poor oral hygiene can have an adverse effect on speech and nutrition, causing general and cognitive health decline.
834:. This can cause food to be refused, or choked on, and help with feeding will often be required. For ease of feeding, food may be liquidized into a thick purée. They may also struggle to walk, particularly among those with 12658: 3051:
Katzmann thus suggested that Alzheimer's disease, if taken to occur over age 65, is actually common, not rare, and was the fourth- or 5th-leading cause of death, even though rarely reported on death certificates in 1976.
2150:
can provide one-to-one support and care in the home allowing for more individualized attention that is needed as the disorder progresses. Psychiatric nurses can make a distinctive contribution to people's mental health.
1053:
onset. The symptoms of DLB are more frequent, more severe, and earlier presenting than in the other dementia subtypes. Dementia with Lewy bodies has the primary symptoms of fluctuating cognition, alertness or attention;
3253:
users for its depiction of the stages of dementia. Caregivers were in favor of this phenomenon; Leyland Kirby, the creator of the record, echoed this sentiment, explaining it could cause empathy among a younger public.
2273:
may be of benefit but the evidence is less conclusive than for AChEIs. Due to their differing mechanisms of action memantine and acetylcholinesterase inhibitors can be used in combination however the benefit is slight.
11585:"The effectiveness and cost-effectiveness of donepezil, galantamine, rivastigmine and memantine for the treatment of Alzheimer's disease (review of Technology Appraisal No. 111): a systematic review and economic model" 827:. They may not want to get out of bed, or may need assistance doing so. Commonly, the person no longer recognizes familiar faces. They may have significant changes in sleeping habits or have trouble sleeping at all. 7679:
Contador, I. et al. (2017) "Impact of literacy and years of education on the diagnosis of dementia:A population-based study,” Journal of Clinical and Experimental Neuropsychology, 39(2), pp. 112–119. Available at:
568:
are often used and may be beneficial in mild to moderate disorder, but the overall benefit may be minor. There are many measures that can improve the quality of life of a person with dementia and their caregivers.
1890:
Sensory impairments of vision and hearing are modifiable risk factors for dementia. These impairments may precede the cognitive symptoms of Alzheimer's disease for example, by many years. Hearing loss may lead to
16348: 16325: 16298: 10240:
Vandepitte S, Van Den Noortgate N, Putman K, Verhaeghe S, Verdonck C, Annemans L (December 2016). "Effectiveness of respite care in supporting informal caregivers of persons with dementia: a systematic review".
15799: 2770:
Dementia impacts not only individuals with dementia, but also their carers and the wider society. Among people aged 60 years and over, dementia is ranked the 9th most burdensome condition according to the 2010
3325: 403:) also classifies dementia as a neurocognitive disorder (NCD) with many forms or subclasses. Dementia is listed as an acquired brain syndrome, marked by a decline in cognitive function, and is contrasted with 1983:(HSV) has been found in more than 70% of those aged over 50. HSV persists in the peripheral nervous system and can be triggered by stress, illness or fatigue. High proportions of viral-associated proteins in 7848:
Teng EL, Hasegawa K, Homma A, Imai Y, Larson E, Graves A, et al. (1994). "The Cognitive Abilities Screening Instrument (CASI): a practical test for cross-cultural epidemiological studies of dementia".
10479:
Jeon YH, Li Z, Low LF, Chenoweth L, O'Connor D, Beattie E, Liu Z, Brodaty H (August 2015). "The clinical utility of the Cornell Scale for Depression in Dementia as a routine assessment in nursing homes".
4952:
Breton A, Casey D, Arnaoutoglou NA (February 2019). "Cognitive tests for the detection of mild cognitive impairment (MCI), the prodromal stage of dementia: Meta-analysis of diagnostic accuracy studies".
2100:
clinical guidance for behavioral and psychological symptoms of dementia (BPSD) along with medication use. Simple measures like talking to people about their interests can improve the quality of life for
1907:
may increase the risk of cognitive decline, and dementia, and the inverse also holds of cognitive impairment increasing the risk of frailty. Prevention of frailty may help to prevent cognitive decline.
1632:) is a reliable screening test and is available online for free in 35 different languages. The MoCA has also been shown somewhat better at detecting mild cognitive impairment than the MMSE. People with 14673:"Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980–2015: a systematic analysis for the Global Burden of Disease Study 2015" 7933:
Nasreddine ZS, Phillips NA, Bédirian V, Charbonneau S, Whitehead V, Collin I, et al. (April 2005). "The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment".
6437: 2499:
medication management are just to name a few. Technology has the potential to be a valuable intervention for alleviating loneliness and promoting social connections, supported by available evidence.
541:
may be taken to rule out other possible causes that may be reversible, such as hypothyroidism (an underactive thyroid), and to determine the dementia subtype. One commonly used cognitive test is the
2950:, special hospitals housed those diagnosed with dementia or insanity, but these did not apply to the emperors, who were above the law and whose health conditions could not be publicly acknowledged. 3695:
Commission de la transparence (June 2012). "Drugs for Alzheimer's disease: best avoided. No therapeutic advantage" [Drugs for Alzheimer's disease: best avoided. No therapeutic advantage].
2961:. Although he repeated existing Aristotelian beliefs that dementia was inevitable, he did make the progressive assertion that the brain was the center of memory and thought rather than the heart. 2453:
related to a 1% fatality rate with a 3% major complication rate. The percentage of people at end of life with dementia using feeding tubes in the US has dropped from 12% in 2000 to 6% as of 2014.
2259:
effects increase all-cause mortality in people with dementia, although the effect of these medications on cognitive function remains uncertain, according to a systematic review published in 2021.
2087:
There are limited options for treating dementia, with most approaches focused on managing or reducing individual symptoms. There are no treatment options available to delay the onset of dementia.
2932:
Cicero's views on aging, although progressive, were largely ignored in a world that would be dominated for centuries by Aristotle's medical writings. Physicians during the Roman Empire, such as
4112: 15494:
Dementia is often incorrectly referred to as "senility" or "senile dementia," which reflects the formerly widespread but incorrect belief that serious mental decline is a normal part of aging.
1911:
There are no medications that can prevent cognitive decline and dementia. However blood pressure lowering medications might decrease the risk of dementia or cognitive problems by around 0.5%.
10564:
Harper AE, Rouch S, Leland NE, Turner RL, Mansbach WE, Day CE, Terhorst L (April 2022). "A Systematic Review of Tools Assessing the Perspective of Caregivers of Residents With Dementia".
3196:
These plans recognize that people can live reasonably with dementia for years, as long as the right support and timely access to a diagnosis are available. Former British Prime Minister
2222:
No medications have been shown to prevent or cure dementia. Medications may be used to treat the behavioral and cognitive symptoms, but have no effect on the underlying disease process.
2445:
and death, assistance with oral feeding is at least as good as tube feeding. Tube-feeding is associated with agitation, increased use of physical and chemical restraints and worsening
3228:
In 2015, Atlantic Philanthropies announced a $ 177 million gift aimed at understanding and reducing dementia. The recipient was Global Brain Health Institute, a program co-led by the
14814:"Apolipoprotein E ε4 Allele-Based Differences in Brain Volumes Are Largely Uniform Across Late Middle Aged and Older Hispanic/Latino- and Non-Hispanic/Latino Whites Without Dementia" 2870:
Until the end of the 19th century, dementia was a much broader clinical concept. It included mental illness and any type of psychosocial incapacity, including reversible conditions.
16971: 13347: 13308: 11815: 4632:"First diagnosis and management of incontinence in older people with and without dementia in primary care: a cohort study using The Health Improvement Network primary care database" 3087:
of the brain. The various forms have differing prognoses and differing epidemiologic risk factors. The main cause for many diseases, including Alzheimer's disease, remains unclear.
556:
Dementia is currently the seventh leading cause of death worldwide and has 10 million new cases reported every year (approximately one every three seconds). There is no known
16455: 13504:
Mitchell SL, Kiely DK, Lipsitz LA (February 1997). "The risk factors and impact on survival of feeding tube placement in nursing home residents with severe cognitive impairment".
1991:(NFTs) confirm the involvement of HSV-1 in Alzheimer's disease pathology. NFTs are known as the primary marker of Alzheimer's disease. HSV-1 produces the main components of NFTs. 11780:
Wang K, Alan J, Page AT, Dimopoulos E, Etherton-Beer C (September 2021). "Anticholinergics and clinical outcomes amongst people with pre-existing dementia: A systematic review".
7536:
Boustani M, Peterson B, Hanson L, Harris R, Lohr KN (June 2003). "Screening for dementia in primary care: a summary of the evidence for the U.S. Preventive Services Task Force".
3047: 2019:
over a long time, can damage nerves and cause memory problems if they are not managed. Nutritional factors associated with the proposed diets for reducing dementia risk include
1879:, is associated with a reduction in age-related brain tissue loss, and neurotoxic factors thereby preserving brain volume and neuronal integrity. Cognitive activity strengthens 15800:"Addressing Alzheimer's and Other Types of Dementia:Israeli National Strategy Summary Document of the Interdisciplinary, Inter-Organizational Group of Experts » Brookdale" 771:
In the early stage of dementia, symptoms become noticeable to other people. In addition, the symptoms begin to interfere with daily activities, and will register a score on a
7735:
Fleisher AS, Sowell BB, Taylor C, Gamst AC, Petersen RC, Thal LJ (May 2007). "Clinical predictors of progression to Alzheimer disease in amnestic mild cognitive impairment".
9767:
Cao L, Tan L, Wang HF, Jiang T, Zhu XC, Lu H, et al. (November 2016). "Dietary Patterns and Risk of Dementia: a Systematic Review and Meta-Analysis of Cohort Studies".
2000:
choices of the elderly population, including the higher intake of gluten-free products, compromise the intake of thiamine as these products are not fortified with thiamine.
10041:
Firth J, Teasdale SB, Allott K, Siskind D, Marx W, Cotter J, Veronese N, Schuch F, Smith L, Solmi M, Carvalho AF, Vancampfort D, Berk M, Stubbs B, Sarris J (October 2019).
1922:
Limited evidence links poor oral health to cognitive decline. However, failure to perform tooth brushing and gingival inflammation can be used as dementia risk predictors.
17357: 17352: 11251:
Raj SE, Mackintosh S, Fryer C, Stanley M (January 1, 2021). "Home-Based Occupational Therapy for Adults With Dementia and Their Informal Caregivers: A Systematic Review".
9395: 2123:(namely, some positive effects in the areas of quality of life, cognition, communication and mood – the first three particularly in care home settings), some benefit for 2015:. These diets are generally low in saturated fats while providing a good source of carbohydrates, mainly those that help stabilize blood sugar and insulin levels. Raised 1484:
using cognitive testing or early diagnosis of dementia has not been shown to improve outcomes. However, screening exams are useful in 65+ persons with memory complaints.
17369: 17347: 9742:"Memory loss can be caused by a number of factors, from short term causes such as low blood sugar or medication side effects to long term health issues such as dementia" 4560: 3270:
Celebrities have used their platforms to raise awareness for the different forms of dementia and the need for further support, including former First Lady of California
3200:
described dementia as a "national crisis", affecting 800,000 people in the United Kingdom. In fact, dementia has become the leading cause of death for women in England.
1662: 18720: 8365:
Bonte FJ, Harris TS, Hynan LS, Bigio EH, White CL (July 2006). "Tc-99m HMPAO SPECT in the differential diagnosis of the dementias with histopathologic confirmation".
7695: 13265:
Stolee P, Hillier LM, Esbaugh J, Bol N, McKellar L, Gauthier N (February 2005). "Instruments for the assessment of pain in older persons with cognitive impairment".
12452:"The effect of treatment with selective serotonin reuptake inhibitors in comparison to placebo in the progression of dementia: a systematic review and meta-analysis" 8632:"Antihypertensive medications and risk for incident dementia and Alzheimer's disease: a meta-analysis of individual participant data from prospective cohort studies" 16006: 17919: 16520: 11022:"An overview of systematic reviews of pharmacological and non-pharmacological interventions for the treatment of behavioral and psychological symptoms of dementia" 9884:"Mediterranean diet adherence is associated with lower dementia risk, independent of genetic predisposition: findings from the UK Biobank prospective cohort study" 2752: 14271:"White paper defining optimal palliative care in older people with dementia: a Delphi study and recommendations from the European Association for Palliative Care" 12072: 8605: 6006:
Abyadeh M, Gupta V, Chitranshi N, Gupta V, Wu Y, Saks D, et al. (April 2021). "Mitochondrial dysfunction in Alzheimer's disease – a proteomics perspective".
3997: 653:
People with dementia are more likely to have problems with incontinence than those of a comparable age without dementia; they are three times more likely to have
16029: 5848: 4471: 3116:
was introduced to suggest the development of senile-type dementia at a younger age. Eventually the two terms fused, so that until 1952 physicians used the terms
2987:, although opinions fluctuated between the idea that it was due to blockage of the major arteries supplying the brain or small strokes within the vessels of the 786:
of planning and organization. Managing finances may prove difficult. Other signs might be getting lost in new places, repeating things, and personality changes.
361:, and their social relationships in general. A diagnosis of dementia requires the observation of a change from a person's usual mental functioning and a greater 15851: 15767: 3727:"Global, regional, and national burden of Alzheimer's disease and other dementias, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016" 3523:"Mini-Mental State Examination (MMSE) for the detection of dementia in clinically unevaluated people aged 65 and over in community and primary care populations" 18750: 16064: 8516:
Zhang YR, Xu W, Zhang W, et al. (October 2022). "Modifiable risk factors for incident dementia and cognitive impairment: An umbrella review of evidence".
3124:
interchangeably. Since then, science has determined that dementia and schizophrenia are two different disorders, though they share some similarities. The term
2946:
physicians sometimes wrote of dementia. It is recorded that at least seven emperors whose lifespans exceeded 70 years displayed signs of cognitive decline. In
2747:
The number of cases of dementia worldwide in 2021 was estimated at 55 million, with close to 10 million new cases each year. According to a report by the
2413:
Although persistent pain in people with dementia is difficult to communicate, diagnose, and treat, failure to address persistent pain has profound functional,
12028: 5678: 12301:"Treatment of dementia and mild cognitive impairment with or without cerebrovascular disease: Expert consensus on the use of Ginkgo biloba extract, EGb 761" 14158: 8409: 2472:
balance of strength exercise, to help muscles pump blood to the brain, and balance exercises are recommended for aging people. A suggested amount of about
2430:
Persons with dementia may have difficulty eating. Whenever it is available as an option, the recommended response to eating problems is having a caretaker
1427: 15557: 13736: 8875: 2011:
diets are both associated with less cognitive decline. A different approach has been to incorporate elements of both of these diets into one known as the
6850:
Nunes PT, Kipp BT, Reitz NL, Savage LM (2019). "Aging with alcohol-related brain damage: Critical brain circuits associated with cognitive dysfunction".
2449:. Tube feedings may cause fluid overload, diarrhea, abdominal pain, local complications, less human interaction and may increase the risk of aspiration. 1402:
develop dementia, though widely varying figures are quoted for this proportion. When dementia occurs in Parkinson's disease, the underlying cause may be
13631:
Finocchiaro C, Galletti R, Rovera G, Ferrari A, Todros L, Vuolo A, Balzola F (June 1997). "Percutaneous endoscopic gastrostomy: a long-term follow-up".
14214: 11676: 698:
Sensory dysfunction is claimed for the pre-clinical stage, which may precede the first clinical signs of dementia by up to ten years. Most notably the
15724:
Jia J, Wei C, Chen S, Li F, Tang Y, Qin W, et al. (April 2018). "The cost of Alzheimer's disease in China and re-estimation of costs worldwide".
10043:"The efficacy and safety of nutrient supplements in the treatment of mental disorders: a meta-review of meta-analyses of randomized controlled trials" 4443: 989:
Vascular dementia accounts for at least 20% of dementia cases, making it the second most common type. It is caused by disease or injury affecting the
15953: 14769:
Sabayan B, Wyman-Chick KA, Sedaghat S (February 2023). "The Burden of Dementia Spectrum Disorders and Associated Comorbid and Demographic Features".
1914:
Economic disadvantage has been shown to have a strong link to higher dementia prevalence, which cannot yet be fully explained by other risk factors.
14510:"Estimation of the global prevalence of dementia in 2019 and forecasted prevalence in 2050: an analysis for the Global Burden of Disease Study 2019" 967:
Several articles have been published on a possible relationship (as an either primary cause or exacerbation of Alzheimer's disease) between general
830:
Changes in eating frequently occur. Cognitive awareness is needed for eating and swallowing and progressive cognitive decline results in eating and
16716: 14508:
Nichols E, Steinmetz JD, Vollset SE, Fukutaki K, Chalek J, Abd-Allah F, et al. (GBD 2019 Dementia Forecasting Collaborators) (February 2022).
4781: 14896: 8203:"Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE) for the early detection of dementia across a variety of healthcare settings" 2953:
Otherwise, little is recorded about dementia in Western medical texts for nearly 1700 years. One of the few references was the 13th-century friar
15967:
Thompson SB (2009). "Testamentary capacity and cognitive rehabilitation: implications for head-injured and neurologically impaired individuals".
13708: 13588:
Lockett MA, Templeton ML, Byrne TK, Norcross ED (February 2002). "Percutaneous endoscopic gastrostomy complications in a tertiary-care center".
11120:"'Singing for the Brain': A qualitative study exploring the health and well-being benefits of singing for people with dementia and their carers" 3203:
There, as with all mental disorders, people with dementia could potentially be a danger to themselves or others, they can be detained under the
18713: 16711: 14671:
Wang H, Naghavi M, Allen C, Barber RM, Bhutta ZA, Carter A, et al. (GBD 2015 Mortality and Causes of Death Collaborators) (October 2016).
10643:"Improving mental health and reducing antipsychotic use in people with dementia in care homes: the WHELD research programme including two RCTs" 601:, restlessness, inappropriate behavior, sexual disinhibition, and verbal or physical aggression. These symptoms may result from impairments in 12734:"Medication appropriateness tool for co-morbid health conditions in dementia: consensus recommendations from a multidisciplinary expert panel" 2367:, be avoided for people with dementia due to the risks of increased cognitive impairment and falls. Benzodiazepines are also known to promote 2066:
may relieve the symptoms given a mild cognitive impairment. Once dementia is advanced no evidence suggests that a gluten-free diet is useful.
964:, and too much build-up of this inflammation leads to changes in the brain that cannot be controlled, leading to the symptoms of Alzheimer's. 19070: 6699: 15173:
Berchtold NC, Cotman CW (1998). "Evolution in the conceptu-alization of dementia and Alzheimer's disease: Greco-Roman period to the 1960s".
10827:
Woods B, Aguirre E, Spector AE, Orrell M (February 2012). "Cognitive stimulation to improve cognitive functioning in people with dementia".
1101: 16513: 15374: 3035:, published a book in which he coined the term "Alzheimer's disease" in an attempt to acknowledge the importance of Alzheimer's discovery. 2775:(GBD) estimates. The global costs of dementia was around US$ 818 billion in 2015, a 35.4% increase from US$ 604 billion in 2010. 2466: 1669: 1003:
may show evidence of multiple strokes of different sizes in various locations. People with vascular dementia tend to have risk factors for
16160: 15631: 13426:"Comfort feeding only: a proposal to bring clarity to decision-making regarding difficulty with eating for persons with advanced dementia" 12550:
Seitz DP, Adunuri N, Gill SS, Gruneir A, Herrmann N, Rochon P (February 2011). "Antidepressants for agitation and psychosis in dementia".
18914: 16203: 15924: 11223: 3622: 2874:
at this time simply referred to anyone who had lost the ability to reason, and was applied equally to psychosis, "organic" diseases like
2756: 2570: 2214:
Offering personally tailored activity sessions to people with dementia in long-term care homes may slightly reduce challenging behavior.
14615: 12152:"Withdrawal versus continuation of chronic antipsychotic drugs for behavioural and psychological symptoms in older people with dementia" 10517:"Development and Validation of a Short Version of the Cornell Scale for Depression in Dementia for Screening Residents in Nursing Homes" 8911:"Loneliness, Social Integration, and Incident Dementia Over 6 Years: Prospective Findings From the English Longitudinal Study of Ageing" 5992: 4906:
Sherman C, Liu CS, Herrmann N, Lanctôt KL (February 2018). "Prevalence, neurobiology, and treatments for apathy in prodromal dementia".
3207:
for assessment, care and treatment. This is a last resort, and is usually avoided by people with family or friends who can ensure care.
18391: 18347: 17450: 1487:
Normally, symptoms must be present for at least six months to support a diagnosis. Cognitive dysfunction of shorter duration is called
13467:
Gillick MR, Volandes AE (June 2008). "The standard of caring: why do we still use feeding tubes in patients with advanced dementia?".
13365: 13326: 11833: 7413:"The merits and problems of Neuropsychiatric Inventory as an assessment tool in people with dementia and other neurological disorders" 1210:. Motor symptoms include a loss of fine motor control leading to clumsiness, poor balance and tremors. Behavioral changes may include 18706: 17339: 1398:
Many other medical and neurological conditions include dementia only late in the illness. For example, a proportion of patients with
15949: 8109: 18921: 18206: 17823: 17636: 12204:"Effectiveness of cholinesterase inhibitors and memantine for treating dementia: evidence review for a clinical practice guideline" 11174:"Exploring psychosocial interventions for people with dementia that enhance personhood and relate to legacy- an integrative review" 9209:
Ford AH, Hankey GJ, Yeap BB, Golledge J, Flicker L, Almeida OP (June 2018). "Hearing loss and the risk of dementia in later life".
6300:
Jurek L, Herrmann M, Bonze M, et al. (March 1, 2018). "Behavioral and psychological symptoms in Lewy body disease: a review".
1617: 396: 12585:(October 2008). "Folic acid with or without vitamin B12 for the prevention and treatment of healthy elderly and demented people". 12403:"Efficacy and safety of ginkgo preparation in patients with vascular dementia: A protocol for systematic review and meta-analysis" 6183:
Baskys A, Cheng JX (November 2012). "Pharmacological prevention and treatment of vascular dementia: approaches and perspectives".
3236:. This donation is the largest non-capital grant Atlantic has ever made, and the biggest philanthropic donation in Irish history. 956:(NFTs) that are formed by hyperphosphorylated tau proteins, are two well-established pathological hallmarks of AD. Amyloid causes 944:. Although this pattern of brain shrinkage suggests Alzheimer's, it is variable and a brain scan is insufficient for a diagnosis. 17616: 17329: 16506: 15456: 13860: 3725:
Nichols E, Szoeke CE, Vollset SE, Abbasi N, Abd-Allah F, Abdela J, et al. (GBD 2016 Dementia Collaborators) (January 2019).
3229: 3217:
with dementia can lead to injury or death. Doctors should advise appropriate testing on when to quit driving. The United Kingdom
2885: 2422:
dementia by learning to recognize and assess their pain. Educational resources and observational assessment tools are available.
2301: 1673:
combines both a patient assessment and an informant interview. It was specifically designed for use in the primary care setting.
96: 15520:
Senile dementia ("senility") is a term that was once used to describe all dementias; this term is no longer used as a diagnosis.
12094:"Dementia: assessment, management and support for people living with dementia and their carers | Guidance and guidelines | NICE" 12093: 6226: 5620: 4596: 3334: 823:
or fall; may not recognize common dangers such as a hot stove; or may not realize that they need to use the bathroom and become
18847: 18770: 17942: 17309: 16982: 14959: 14934: 10739:
Vernooij-Dassen M, Draskovic I, McCleery J, Downs M (November 2011). "Cognitive reframing for carers of people with dementia".
4570: 4457: 2371:. Additionally, little evidence supports the effectiveness of benzodiazepines in this population. No clear evidence shows that 1193: 9298:"Association of Blood Pressure Lowering With Incident Dementia or Cognitive Impairment: A Systematic Review and Meta-analysis" 2912:
texts made allusions to the condition as well, and the characters for "dementia" translate literally to "foolish old person".
2202:
is beneficial for people with Parkinson's disease, dementia, or mild cognitive impairment. However, a 2023 review found that
2051:
needs further study as it may be one of the most important components in reducing the risk of cognitive decline and dementia.
17334: 16966: 14879: 14322:"A critical literature review exploring the challenges of delivering effective palliative care to older people with dementia" 11741:"Syncope and its consequences in patients with dementia receiving cholinesterase inhibitors: a population-based cohort study" 10931: 9653:
Hoffman, R. (2016). Thiamine deficiency in the Western diet and dementia risk. British Journal Of Nutrition, 116(1), 188–189.
7471: 7319: 6867: 5986: 5824: 5297: 5272: 4247: 4096: 3949: 3616: 9716: 8250:
Jacova C, Kertesz A, Blair M, Fisk JD, Feldman HH (October 2007). "Neuropsychological testing and assessment for dementia".
2441:
placement as a way to give nutrition. However, in bringing comfort and maintaining functional status while lowering risk of
1644:) is a five-minute test that is highly sensitive to the early stages of dementia, and uses an application deliverable to an 909:
Alzheimer's disease accounts for 60–70% of cases of dementia worldwide. The most common symptoms of Alzheimer's disease are
670:
Assessment of Primary Degenerative Dementia (GDS or Reisberg Scale), the Functional Assessment Staging Test (FAST), and the
18938: 17172: 17160: 16622: 15981:"Testamentary capacity and cognitive rehabilitation: implications for head-injured and neurologically impaired individuals" 11393:
Kudlicka A, Martyr A, Bahar-Fuchs A, et al. (June 29, 2023). Cochrane Dementia and Cognitive Improvement Group (ed.).
7718: 2404: 2114: 1897: 1865: 8025: 3965: 18403: 17551: 15998: 9166:
Hubbard HI, Mamo SK, Hopper T (July 2018). "Dementia and Hearing Loss: Interrelationships and Treatment Considerations".
2435: 407:. It is also described as a spectrum of disorders with causative subtypes of dementia based on a known disorder, such as 14868:"Delirium, Dementia, and Amnestic and Other Cobnitive Disorders and Mental Disorders Due to a General Medical Condition" 14812:
Ariana M. Stickel, Andrew C. McKinnon, Stephanie Matijevik, Matthew D. Grilli, John Ruiz, Lee Ryam (February 26, 2021).
14641: 12501:
Dudas R, Malouf R, McCleery J, Dening T, et al. (Cochrane Dementia and Cognitive Improvement Group) (August 2018).
10516: 8598: 7397: 7341:
Caplan JP, Rabinowitz T (November 2010). "An approach to the patient with cognitive impairment: delirium and dementia".
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Symptoms are similar across dementia types and it is difficult to diagnose by symptoms alone. Diagnosis may be aided by
522:. Some of the neurocognitive deficits may sometimes show improvement with treatment of the causative medical condition. 19050: 18904: 17653: 17628: 17463: 17391: 17324: 16879: 12054: 4007: 3492: 2795: 1351:. These types of dementias can rapidly progress, but usually have a good response to early treatment. This consists of 455:. Subtypes of neurodegenerative dementias may also be based on the underlying pathology of misfolded proteins, such as 16021: 15825: 15667:"The prevalence and predictors of loneliness in caregivers of people with dementia: findings from the IDEAL programme" 18931: 18864: 18859: 18800: 18795: 18439: 18259: 18157: 17094: 16897: 16460: 15774: 15260: 15227: 13059:
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Additional Alzheimer's awareness has been raised through the diagnoses of high-profile persons themselves, including
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patients with Alzheimer's disease. The bacteria invade nerve tissue in the brain, increasing the permeability of the
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on April 11, 1906; however, the information was poorly received by his peers. By 1910, Alois Alzheimer's teacher,
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argued that the terms of a man's will might be invalidated if he exhibited loss of judgement due to advanced age.
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Many neurocognitive disorders may be caused by another medical condition or disorder, including brain tumours and
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In addition to the above risk factors, other psychological features, including certain personality traits (high
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may cause episodes of confusion and psychiatric disturbance, dementia is a rare feature of these rare diseases.
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cognitive impairment and that celiac disease may be associated with Alzheimer's disease, vascular dementia, and
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as "mild neurocognitive disorders", i.e. milder forms of the major neurocognitive disorder (dementia) subtypes.
609:(most often visual), delusions, apathy, and anxiety. The most commonly affected areas of brain function include 19065: 18909: 18879: 18830: 18825: 18780: 18765: 18426: 18211: 18182: 17443: 16728: 16704: 16534: 12120: 11444:"Personally tailored activities for improving psychosocial outcomes for people with dementia in long-term care" 4754: 2998:
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Alcohol-related dementia, also called alcohol-related brain damage, occurs as a result of excessive use of
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is lost, associated with depression and a loss of appetite leading to poor nutrition. It is suggested that
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may be effective in helping individuals with mild to moderate dementia to manage their daily activities.
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that regulates microbiome signalling, immune cell response, and neuronal excitation. A disruption in the
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Mrs. Colorado Springs uses title, young-onset Alzheimer's diagnosis to spread awareness about dementia
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patients who are diagnosed with dementia, finding a positive correlation between the two diseases.
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protein. Symptoms include cognitive impairment and this usually declines further into dementia.
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was the appropriate term for persons with that particular brain pathology, regardless of age.
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The symptoms of early dementia usually include memory difficulty, but can also include some
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the general older population for the disorder is not seen to affect the outcome.
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has been established in predictive diagnosis, particularly Alzheimer's disease.
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mood swings, such as irritability or aggressive behavior to insignificant things
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Decreased ability to think and remember, emotional problems, problems with
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Long-term brain disorders causing impaired memory, thinking and behavior
18683: 18376: 18281: 17982: 17707: 17702: 17498: 16759: 16629: 16424: 16086: 15773:. London: Alzheimer's Disease International. April 2012. Archived from 15693: 14737: 14297: 11086: 10659: 10642: 10164: 8794: 7429: 5017: 4561:"Alzheimer's Takes a Financial Toll Long Before Diagnosis, Study Finds" 3810:"Olfactory dysfunction in the pathophysiological continuum of dementia" 3313: 3258: 3060: 2901: 2836: in this section. Unsourced material may be challenged and removed. 2658:
for Alzheimer and other dementias per 100,000 inhabitants in 2004
2309: 2305: 2119:
Psychological therapies for dementia include some limited evidence for
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may be appropriate for treating the associated symptoms of depression.
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The prodromal symptoms of dementia with Lewy bodies (DLB) include
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This article is about the cognitive disorder. For other uses, see
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The part of the brain most affected by Alzheimer's is the
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A 19th-century drawing of a woman diagnosed with dementia
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Sensitivity and specificity of common tests for dementia
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following a period of dementia-free Parkinson's disease.
498:, infections, immune disorders, liver or kidney failure, 14557:
Gale SA, Acar D, Daffner KR (October 2018). "Dementia".
14395: 14393: 13761:
Flynn E, Smith CH, Walsh CD, Walshe M (September 2018).
13145: 12824: 12347: 12243:
Atri A, Shaughnessy LW, Locascio JJ, Growdon JH (2008).
11582: 10290: 8292: 7033: 7031: 7029: 7027: 5978:
Clinical diagnosis and management of Alzheimer's disease
4629: 2193: 18313: 16488: 15172: 13264: 13042: 12549: 12015: 11738: 10563: 10090:
Hafdi M, Hoevenaar-Blom MP, Richard E (November 2021).
7975: 7466:. Clifton Park, NY: Delmar Learning. pp. 297–298. 6337: 6335: 6333: 6331: 5853:
National Institute of Neurological Disorders and Stroke
5444: 4951: 4597:"Continence, dementia, and care that preserves dignity" 2527:
Given the progressive and terminal nature of dementia,
1130:(loss of motor neurons). Two FTD-related disorders are 16204:"Reagan's Letter Announcing his Alzheimer's Diagnosis" 15664: 14670: 14156: 12883:"Pharmacotherapies for sleep disturbances in dementia" 11905:"Comprehensive treatment of dementia with Lewy bodies" 11779: 11117: 9208: 8407: 8249: 8026:"How to identify dementia in people with hearing loss" 7584:"A review of screening tests for cognitive impairment" 7072: 6977: 6975: 6398:"New evidence on the management of Lewy body dementia" 5925: 5873: 5579: 3211:
positive mood and allow residents to see more easily.
2351:
medications that are commonly prescribed. In 2012 the
2139:
or improve for the quality of life for the caregiver.
1871:
The two most modifiable risk factors for dementia are
372:
Several diseases and injuries to the brain, such as a
248:
Early education, prevent high blood pressure, prevent
18994: 17458: 15558:"The Relationship Between Schizophrenia and Dementia" 14390: 13958: 13935:"7 Technological Innovations for Those With Dementia" 13887:"Assistive technology for memory support in dementia" 13760: 13469:
Journal of the American Medical Directors Association
13380: 13352:"Five Things Physicians and Patients Should Question" 13313:"Five Things Physicians and Patients Should Question" 12503:"Antidepressants for treating depression in dementia" 12449: 12055:"Five Things Physicians and Patients Should Question" 12025:
Choosing Wisely: An Initiative of the ABIM Foundation
12021:"Five Things Physicians and Patients Should Question" 11292: 11290: 10954: 10872: 8364: 8336:"Diagnostic approach to the confused elderly patient" 7847: 7259: 7024: 6796:"Alcohol-related dementia: an update of the evidence" 5586:
Della Sala S, Spinnler H, Venneri A (February 2004).
5487: 5380:
Journal of the American Medical Directors Association
5320: 4472:"Dementia: comorbidities in patients – data briefing" 2893:
Dementia has been referred to in medical texts since
1198:
HIV-associated dementia results as a late stage from
605:. The psychological symptoms can include depression, 16280: 14607:
Alzheimer's Disease International (September 2015).
14355: 13503: 12780: 12118: 12011: 12009: 12007: 12005: 12003: 12001: 11999: 11820:"Ten Things Physicians and Patients Should Question" 11544: 11441: 11171: 10293:"Palliative care interventions in advanced dementia" 6849: 6571: 6328: 5855:. US National Institutes of Health. January 10, 2020 4805: 4229: 2546:
helps maintain the dignity of people with dementia.
2387:
may improve sleep, however more research is needed.
2326:
improves outcomes in those with cognitive problems.
1530:
Executive dysfunction § Testing and measurement
1472:
techniques. In many cases, the diagnosis requires a
1428:
Limbic-predominant age-related TDP-43 encephalopathy
1218:
and diminished emotional responses and spontaneity.
1180:
stumbling and clumsiness that is out of the ordinary
15950:"Drivers with dementia a growing problem, MDs warn" 15313:Yang HD, Kim DH, Lee SB, Young LD (December 2016). 14990:
Clinical Practice and Epidemiology in Mental Health
13727:"The Decline of Tube Feeding for Dementia Patients" 12580: 12450:Jones HE, Joshi A, Shenkin S, Mead GE (July 2016). 11692:"Cholinesterase inhibitors for Alzheimer's disease" 11118:Osman SE, Tischler V, Schneider J (November 2016). 10873:Möhler R, Renom A, Renom H, Meyer G (August 2020). 10515:Jeon YH, Liu Z, Li Z, et al. (November 2016). 9994:"Omega-3 fatty acids for the treatment of dementia" 9665: 7170: 6972: 6793: 6341: 6250: 5926:Arvanitakis Z, Shah RC, Bennett DA (October 2019). 5287: 5048: 4998: 4584:
likely to be delinquent on their credit card bills.
4278: 4031: 3941:
Memory loss : a practical guide for clinicians
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Maria Shriver | My Brain™ | Alzheimer’s Association
2519:are harmful or effective for people with dementia. 1264:Creutzfeldt–Jakob disease is a rapidly progressive 207:
Lack of education and socialization, family history
17476: 14894: 11287: 10478: 7588:Journal of Neurology, Neurosurgery, and Psychiatry 6751:Journal of Neurology, Neurosurgery, and Psychiatry 6299: 5595:Journal of Neurology, Neurosurgery, and Psychiatry 5292:. Chichester, West Sussex: John Wiley & Sons. 4406:"Hallucinations: MedlinePlus Medical Encyclopedia" 2574:Deaths per million persons in 2012 due to dementia 353:. The symptoms may be described as occurring in a 16494:National Institute on Aging – Alzheimer's disease 13959:Anderson M, Menon R, Oak K, Allan L (June 2022). 13538: 12876: 12874: 12872: 12870: 12820: 12818: 12479:20.500.11820/56792c91-31f0-44cb-8ac0-7f50fad8d91e 12400: 11996: 11631: 11246: 11244: 10795: 10429: 9165: 7037: 6395: 4759:Fisher Center for Alzheimer's Research Foundation 4330: 3851: 3015:. Alzheimer conducted the brain biopsy using the 2209: 2165:value of the person and improve quality of life. 1134:(also classed as a Parkinson-plus syndrome), and 19042: 17885: 15499: 15367:"Drug Trials Test Bold Plan to Slow Alzheimer's" 15215: 15031: 15029: 13861:"Preventing Alzheimer's Disease – HelpGuide.org" 12880: 12298: 11296: 11167: 11165: 11163: 10436:Dementia and Geriatric Cognitive Disorders Extra 10391:"Origins of Montessori Programming for Dementia" 7577: 7575: 7340: 7121: 6700:"HIV-Associated Dementia – Neurologic Disorders" 6051:"Neuropathologic changes in Alzheimer's disease" 3807: 1938:. In the oral cavity, bacterial species include 1323:that may affect the brain and cognition include 726:Pre-dementia states considered as prodromal are 15312: 14556: 14361: 13466: 13223: 12978: 10868: 10866: 9766: 6572:Lopez G, Bayulkem K, Hallett M (October 2016). 6129: 6127: 4279:Kales HC, Gitlin LN, Lyketsos CG (March 2015). 3966:"ICD-11 for Mortality and Morbidity Statistics" 3933: 3931: 3929: 3927: 3925: 3923: 3180:Woman with dementia being cared for at home in 810:into having the condition will become evident. 710:is exposed to the environment, and the lack of 18658: 14861: 14859: 14213:: CS1 maint: DOI inactive as of August 2024 ( 13858: 13756: 13754: 12867: 12815: 11675:: CS1 maint: DOI inactive as of August 2024 ( 11241: 10286: 10284: 10282: 10280: 9495: 9493: 9491: 7777: 7461: 5928:"Diagnosis and Management of Dementia: Review" 4856: 4690:Therapeutic Advances in Neurological Disorders 4531:Federal Reserve Bank of New York Staff Reports 3921: 3919: 3917: 3915: 3913: 3911: 3909: 3907: 3905: 3903: 3257:On November 2, 2020, Scottish billionaire Sir 2957:, who viewed old age as divine punishment for 1748:is commonly performed to possibly find either 921:(getting lost often), reasoning, judgment and 18714: 17444: 16514: 16113:"Alzheimer's Association Celebrity Champions" 15581: 15026: 14639: 14313: 14227: 14221: 14150: 11947: 11578: 11576: 11160: 10948: 10508: 10472: 10423: 10382: 10243:International Journal of Geriatric Psychiatry 9717:"Diet Affects Markers of Alzheimer's Disease" 9499: 8832:International Journal of Geriatric Psychiatry 8557:International Journal of Geriatric Psychiatry 8544: 8458: 8134:"FDA Clears 5-Minute Test for Early Dementia" 7771: 7728: 7687: 7682:https://doi.org/10.1080/13803395.2016.1204992 7572: 7529: 7038:Zis P, Hadjivassiliou M (February 26, 2019). 6919: 6391: 6389: 6387: 5841: 5049:Cervenka I, Agudelo LZ, Ruas JL (July 2017). 4955:International Journal of Geriatric Psychiatry 3992: 3990: 3988: 3986: 3937: 3808:Bathini P, Brai E, Auber LA (November 2019). 2550:Remotely delivered information for caregivers 1845:seen even in those with a high genetic risk. 107:of a man diagnosed with dementia in the 1800s 15723: 15474: 15389: 15078: 14901:The Primary Care Companion for CNS Disorders 14865: 14633: 14110:"Cannabinoids for the treatment of dementia" 13812:"Exercise programs for people with dementia" 13718: 11540: 11538: 11253:The American Journal of Occupational Therapy 11015: 11013: 10863: 10614:(Plain English summary). November 26, 2020. 10521:The American Journal of Geriatric Psychiatry 10482:The American Journal of Geriatric Psychiatry 10342:"Exercise programs for people with dementia" 8515: 8417:The American Journal of Geriatric Psychiatry 7841: 7814: 7164: 7127: 6124: 5874:Hershey LA, Coleman-Jackson R (April 2019). 5543:The Journal of Nutrition, Health & Aging 5539:"Editorial: Dysphagia, Dementia and Frailty" 4174: 4032:Wilson H, Pagano G, Politis M (March 2019). 3636: 3634: 3632: 2467:Neurobiological effects of physical exercise 2198:There is no strong evidence to suggest that 1670:General Practitioner Assessment Of Cognition 1375:Cases of easily reversible dementia include 1253: 1100:in personality and behavior. This is called 17233: 15584:"Family caregivers of people with dementia" 15457:"Alzheimer's disease – Symptoms and causes" 14856: 14406:The Cochrane Database of Systematic Reviews 14319: 14114:The Cochrane Database of Systematic Reviews 14065:The Cochrane Database of Systematic Reviews 14016:The Cochrane Database of Systematic Reviews 13891:The Cochrane Database of Systematic Reviews 13816:The Cochrane Database of Systematic Reviews 13767:The Cochrane Database of Systematic Reviews 13751: 13545:The Cochrane Database of Systematic Reviews 13539:Sampson EL, Candy B, Jones L (April 2009). 13258: 13224:Herr K, Bjoro K, Decker S (February 2006). 13021: 12887:The Cochrane Database of Systematic Reviews 12831:The Cochrane Database of Systematic Reviews 12689:The Cochrane Database of Systematic Reviews 12625:The Cochrane Database of Systematic Reviews 12587:The Cochrane Database of Systematic Reviews 12552:The Cochrane Database of Systematic Reviews 12507:The Cochrane Database of Systematic Reviews 12159:The Cochrane Database of Systematic Reviews 11847: 11696:The Cochrane Database of Systematic Reviews 11448:The Cochrane Database of Systematic Reviews 11067:The Cochrane Database of Systematic Reviews 10879:The Cochrane Database of Systematic Reviews 10829:The Cochrane Database of Systematic Reviews 10798:The Cochrane Database of Systematic Reviews 10741:The Cochrane Database of Systematic Reviews 10696:The Cochrane Database of Systematic Reviews 10346:The Cochrane Database of Systematic Reviews 10297:The Cochrane Database of Systematic Reviews 10277: 10096:The Cochrane Database of Systematic Reviews 9998:The Cochrane Database of Systematic Reviews 9500:Olsen I, Singhrao SK (September 17, 2015). 9488: 9012:"Hearing interventions to prevent dementia" 8408:Dougall NJ, Bruggink S, Ebmeier KP (2004). 8207:The Cochrane Database of Systematic Reviews 8065:The Cochrane Database of Systematic Reviews 6182: 5849:"Lewy body dementia: Hope through research" 5754: 5536: 5182: 4187:The Cochrane Database of Systematic Reviews 3900: 3527:The Cochrane Database of Systematic Reviews 1444:that can also cause dementia include: some 1058:(RBD); one or more of the main features of 365:decline than might be caused by the normal 15: 18721: 18707: 18348:Other specified feeding or eating disorder 17615: 17451: 17437: 16521: 16507: 16186:"Doctor: Rosa Parks suffers from dementia" 15872: 15219:Diagnosis and treatment of senile dementia 14448: 13430:Journal of the American Geriatrics Society 13387:Journal of the American Geriatrics Society 13267:Journal of the American Geriatrics Society 12936:Journal of the American Geriatrics Society 12923: 12294: 12292: 12290: 12288: 12249:Alzheimer Disease and Associated Disorders 11573: 11490: 11297:Frankenstein LL, Jahn G (April 20, 2020). 10981: 9549:"Can poor oral health lead to dementia?". 7982:Journal of the American Geriatrics Society 7935:Journal of the American Geriatrics Society 6988:Current Neurology and Neuroscience Reports 6694: 6692: 6384: 5755:Chung CG, Lee H, Lee SB (September 2018). 5494:Current Neurology and Neuroscience Reports 5488:Sunderaraman P, Cosentino S (March 2017). 5447:Current Neurology and Neuroscience Reports 4994: 4992: 4799: 4779: 4679: 4677: 4027: 4025: 3983: 3803: 3801: 3799: 3797: 3795: 3690: 3688: 3686: 3462: 3460: 3458: 3456: 3408: 3136:). After about 1920, the beginning use of 2763:gene than do non-Hispanic white subjects. 1311:more parts of the brain will be affected. 1222:, it is identified by the infiltration of 1122:A frontotemporal dementia associated with 650:can be an early indicator of the disease. 525:Diagnosis of dementia is usually based on 391:with varying degrees of severity and many 95: 16: 15692: 15682: 15607: 15338: 15308: 15306: 15304: 15302: 15300: 15298: 15296: 15294: 15106: 15096: 15009: 14839: 14829: 14745: 14696: 14550: 14533: 14425: 14296: 14286: 14245: 14133: 14084: 14035: 13986: 13976: 13910: 13835: 13786: 13694: 13564: 13449: 13406: 13241: 13122: 13100: 13098: 12955: 12906: 12881:McCleery J, Sharpley AL (November 2020). 12850: 12798: 12787:Journal of Pharmacy Practice and Research 12757: 12708: 12644: 12526: 12477: 12467: 12426: 12377: 12324: 12268: 12219: 12178: 11979: 11930: 11920: 11896: 11879: 11756: 11715: 11608: 11535: 11518: 11508: 11467: 11418: 11369: 11199: 11189: 11172:Johnston B, Narayanasamy M (April 2016). 11143: 11094: 11037: 11010: 10898: 10748: 10715: 10658: 10540: 10514: 10455: 10406: 10395:Non-pharmacological Therapies in Dementia 10365: 10333: 10316: 10172: 10115: 10066: 10017: 9968: 9958: 9909: 9899: 9857: 9839: 9760: 9691: 9661: 9659: 9542: 9525: 9471: 9461: 9437: 9370: 9321: 9142: 9123:Laryngoscope Investigative Otolaryngology 9093: 9083: 9061: 9059: 9057: 9055: 9035: 8986: 8956: 8954: 8934: 8851: 8802: 8753: 8704: 8655: 8492: 8482: 8310: 8226: 8084: 7993: 7909: 7656: 7607: 7512: 7438: 7428: 7287: 7277: 7255: 7253: 7055: 7007: 6947: 6925: 6877: 6821: 6811: 6770: 6646: 6614: 6597: 6523: 6474: 6421: 6367: 6276: 6227:"Vascular dementia – Symptoms and causes" 6159: 6107: 6097: 5951: 5899: 5780: 5731: 5721: 5654: 5606: 5554: 5513: 5399: 5350: 5321:Rohrer JD, Knight WD, Warren JE, Fox NC, 5257:American Psychiatric Association (2013). 5208: 5156: 5115: 5066: 5025: 4947: 4945: 4882: 4850: 4833: 4823: 4709: 4657: 4647: 4558: 4460:. American Speech Language D Association. 4429: 4356: 4304: 4206: 4157: 4081:American Psychiatric Association (2013). 4057: 3883: 3750: 3720: 3718: 3666: 3629: 3611:. American Psychiatric Pub. p. 311. 3556: 3548:1983/00876aeb-2061-43f5-b7e1-938c666030ab 3546: 3516: 3514: 3454: 3452: 3450: 3448: 3446: 3444: 3442: 3440: 3438: 3436: 2852:Learn how and when to remove this message 1533: 284:Varies, life expectancy usually shortened 18751:Attention deficit hyperactivity disorder 18611:Disorganized (hebephrenic) schizophrenia 18207:Depersonalization-derealization disorder 16454:) is being considered for deletion. See 15978: 15966: 15952:. CBC News, Canada. September 19, 2007. 15638:(Plain English summary). July 22, 2020. 15276: 15274: 15272: 14664: 13852: 13714:from the original on September 21, 2017. 12676: 12348:McKeage K, Lyseng-Williamson KA (2018). 12341: 11953: 11690:Birks J (January 2006). Birks JS (ed.). 11683: 9874: 9666:Dominguez LJ, Barbagallo M (June 2018). 9443: 9159: 9110: 8599:"vascular risk factors and brain health" 7891: 7820: 7550:10.7326/0003-4819-138-11-200306030-00015 7400:from the original on September 29, 2007. 6845: 6843: 6841: 6744: 6448: 6442: 6133: 5974: 5042: 4806:Bhatia-Dey N, Heinbockel T (June 2021). 4326: 4324: 4105: 3324:Former Mrs. Colorado Springs Joanna Fix 3175: 3095:Dementia in the elderly was once called 2884: 2650: 2569: 2224: 2109:Psychological and psychosocial therapies 1618:Cognitive Abilities Screening Instrument 896: 549:, are preventable by lifestyle changes. 397:International Classification of Diseases 321:. This typically involves problems with 260:Varies, some types can be reversed, but 141:, general decline in cognitive abilities 24:This is an accepted version of this page 16009:from the original on February 11, 2016. 15823: 15395: 15129: 13368:from the original on September 13, 2014 13329:from the original on September 13, 2014 13191:British Journal of Occupational Therapy 13022:Lolk A, Gulmann NC (October 2006). "". 12972: 12618:"Statins for the treatment of dementia" 12285: 12221:10.7326/0003-4819-148-5-200803040-00009 12086: 11399:Cochrane Database of Systematic Reviews 11350:Cochrane Database of Systematic Reviews 9072:Therapeutic Advances in Chronic Disease 8882:(Plain English summary). May 27, 2020. 8128: 8126: 7792:10.7326/0003-4819-138-5-200303040-00011 7375: 6794:Ridley NJ, Draper B, Withall A (2013). 6689: 6244: 6136:"The pathobiology of vascular dementia" 5921: 5919: 5178: 5176: 5083: 4989: 4899: 4683: 4674: 4398: 4159:10.7326/0003-4819-159-9-201311050-00730 4022: 3792: 3683: 3625:from the original on September 8, 2017. 3230:University of California, San Francisco 2502: 2489: 2302:selective serotonin reuptake inhibitors 1141: 682:Pre-dementia includes pre-clinical and 14: 19043: 17310:Distal hereditary motor neuronopathies 16983:Template:Demyelinating diseases of CNS 16158: 16019: 15582:Brodaty H, Donkin M (April 29, 2017). 15361: 15291: 13739:from the original on September 3, 2016 13230:Journal of Pain and Symptom Management 13182: 13139: 13095: 12031:from the original on September 1, 2013 10921: 10034: 9656: 9591: 9052: 9003: 8951: 8591: 7250: 7213: 6787: 6747:"Molecular neurology of prion disease" 6497: 6176: 5803: 5438: 5288:Jenkins C, Ginesi L, Keenan B (2016). 4942: 4373: 4135: 4133: 3958: 3715: 3511: 3433: 3171: 2507:Evidence of the therapeutic values of 2425: 1307:damage to blood vessels in the brain. 1194:HIV-associated neurocognitive disorder 1138:. These disorders are tau-associated. 1069: 886: 571:Cognitive and behavioral interventions 18702: 18657: 18525: 18460: 18312: 18039: 17884: 17794: 17614: 17475: 17432: 16502: 16471:"Result List: PM 32016328: EBSCOhost" 16067:from the original on October 23, 2020 16032:from the original on October 22, 2020 15956:from the original on October 2, 2007. 15854:from the original on October 20, 2013 15319:Dementia and Neurocognitive Disorders 15269: 15250: 15123: 14952: 14449:Dooley B, Ueno H (February 2, 2022). 13217: 13188: 12394: 12236: 12195: 12075:from the original on December 3, 2013 11689: 10647:Programme Grants for Applied Research 9934: 9202: 9009: 8960: 7369: 6838: 6620: 6565: 6293: 5748: 5626:from the original on October 9, 2022. 5530: 4857:Boesveldt S, Parma V (January 2021). 4464: 4331:Şahin Cankurtaran E (December 2014). 4321: 4272: 4223: 4074: 3604: 3359:Rita Hayworth's misdiagnosed struggle 3318:40th President of the United States, 2968:notably mentions it in plays such as 2391:nursing home or long-term care home. 2345: 2194:Cognitive training and rehabilitation 2127:for caretakers, unclear evidence for 1156:caused by mutations in a single gene 576: 389:mild or major neurocognitive disorder 19071:Mental disorders due to brain damage 17795: 17161:Idiopathic intracranial hypertension 16550: 16050: 15410:10.1001/archneur.1976.00500040001001 14621:from the original on October 9, 2022 13724: 13518:10.1001/archinte.1997.00440240091014 11902: 11559:10.1146/annurev.med.57.121304.131442 11491:Rafii MS, Aisen PS (February 2009). 10388: 9940: 8611:from the original on October 9, 2022 8157: 8123: 8101: 7898:Archives of Clinical Neuropsychology 7404: 7343:The Medical Clinics of North America 7130:Journal of the Neurological Sciences 6984:"Immunologically mediated dementias" 6710: 6082:"Alzheimer's disease and anesthesia" 6048: 5916: 5250: 5173: 5138: 5132: 4446:from the original on April 27, 2009. 3573: 2927:For comparison, the Roman statesman 2834:adding citations to reliable sources 2805: 2660: 2576: 2457:dementia should also be considered. 2405:Pain Assessment in Advanced Dementia 2267:N-methyl-D-aspartate (NMDA) receptor 2115:Psychological therapies for dementia 1898:central auditory processing disorder 1866:English Longitudinal Study of Ageing 1519: 1504:, may produce symptoms that must be 380:, a neurodegenerative disorder. The 18848:Epidemiology of Alzheimer's disease 18314:Physiological and physical behavior 15969:Journal of Cognitive Rehabilitation 12305:CNS Neuroscience & Therapeutics 11836:from the original on April 12, 2015 10692:"Reminiscence therapy for dementia" 9714: 7410: 7304: 6623:"Treatment of Huntington's disease" 5481: 4747: 4726: 4430:Shub D, Kunik ME (April 16, 2009). 4234:. Vol. 167. pp. 437–454. 4130: 1680: 789:In some types of dementia, such as 657:and four times more likely to have 419:for Huntington's disease dementia, 48: 18260:Psychogenic non-epileptic seizures 17654:Emotional and behavioral disorders 17392:Infantile progressive bulbar palsy 15588:Dialogues in Clinical Neuroscience 15505: 15377:from the original on April 9, 2012 8379:10.1097/01.rlu.0000222736.81365.63 7823:The Journal of Clinical Psychiatry 7749:10.1212/01.wnl.0000258542.58725.4c 7505:10.1001/jamanetworkopen.2021.36553 7322:from the original on June 29, 2009 7185:10.1212/01.wnl.0000242630.52203.8f 6540: 6055:The Journal of Clinical Psychiatry 5537:Payne M, Morley JE (May 1, 2018). 4240:10.1016/B978-0-12-804766-8.00024-8 2522: 1883:and together they help to support 1808:Risk factors for dementia include 993:, typically involving a series of 686:stages. The latter stage includes 49: 19082: 18440:Hypoactive sexual desire disorder 17095:Template:Cerebrovascular diseases 16898:Frontotemporal lobar degeneration 16458:to help reach a consensus. › 16276: 14646:Alzheimer's Disease International 14234:European Journal of Public Health 13243:10.1016/j.jpainsymman.2005.07.001 11259:(1): 7501205060p1–7501205060p27. 9672:Acta Bio Medica: Atenei Parmensis 6671:"Huntington's disease – Symptoms" 5995:from the original on May 3, 2016. 5811:(1st ed.). Springer: Japan. 5183:Hugo J, Ganguli M (August 2014). 3581:"Differential diagnosis dementia" 2315:No solid evidence indicates that 1930:The link between Alzheimer's and 1804:Neuroplastic effects of pollution 1420:frontotemporal lobar degeneration 1301: 1088: 437:frontotemporal lobar degeneration 387:, has re-described dementia as a 19028: 19016: 19004: 17740:X-linked intellectual disability 17115:For more detailed coverage, see 17093:For more detailed coverage, see 17064:For more detailed coverage, see 17030:For more detailed coverage, see 16981:For more detailed coverage, see 16247: 16221: 16196: 16178: 16152: 16138:"Willis Family Statement | AFTD" 16130: 16105: 16079: 16044: 16013: 15991: 15960: 15942: 15917: 15866: 15817: 15792: 15760: 15717: 15658: 15624: 15600:10.31887/DCNS.2009.11.2/hbrodaty 15575: 15550: 15525: 15449: 15432:"Prevalence by gender in the UK" 15424: 15355: 15315:"History of Alzheimer's Disease" 15244: 15209: 15166: 15079:Jessop T, Peisah C (July 2021). 15072: 14977: 14927: 14888: 14805: 14762: 14713: 14501: 14476: 14442: 14341:10.1111/j.1365-2702.2007.02220.x 14262: 14228:Van den Block L (October 2014). 14101: 14052: 14012:"Massage and touch for dementia" 14003: 13952: 13927: 13878: 13803: 13659: 13624: 13581: 13532: 13497: 13442:10.1111/j.1532-5415.2010.02740.x 13399:10.1111/j.1532-5415.2012.04148.x 13340: 13301: 13279:10.1111/j.1532-5415.2005.53121.x 13015: 12948:10.1111/j.1532-5415.2012.03923.x 12774: 12725: 12609: 12574: 12543: 12494: 12443: 12358:Drugs & Therapy Perspectives 12143: 12112: 12069:American Psychiatric Association 12051:American Psychiatric Association 12043: 11808: 11773: 11732: 11625: 11484: 11435: 11386: 11337: 11216: 11111: 11054: 10996:10.7748/ns2006.08.20.47.42.c4477 10975: 10915: 10820: 10789: 10732: 10634: 10600: 10557: 10233: 10189: 10140: 10083: 9985: 9811: 9734: 9708: 9647: 9638: 9629: 9585: 9387: 9338: 9289: 8902: 8868: 8819: 8770: 8721: 8672: 8623: 8509: 8401: 8358: 8327: 8286: 8243: 8194: 8151: 8052: 8018: 7969: 7947:10.1111/j.1532-5415.2005.53221.x 7926: 7885: 7673: 7624: 7480: 5233:"Advance Directive for Dementia" 4755:"Clinical Stages of Alzheimer's" 2810: 2782: 2558:In several localities in Japan, 2401:Assessment in nonverbal patients 1925: 1917: 971:and Alzheimer's in specifically 17569:Intermittent explosive disorder 17494:Ego-dystonic sexual orientation 15216:Bergener M, Reisberg B (1989). 15038:Nature Reviews. Disease Primers 14818:Frontiers in Aging Neuroscience 11794:10.1016/j.maturitas.2021.06.004 9450:Frontiers in Aging Neuroscience 9223:10.1016/j.maturitas.2018.03.004 9168:Seminars in Speech and Language 8107: 7417:Clinical Interventions in Aging 7334: 7207: 6894: 6738: 6704:MSD Manual Professional Edition 6663: 6491: 6219: 6073: 6042: 5999: 5968: 5867: 5797: 5697: 5671: 5630: 5424:"Diagnosing Lewy Body Dementia" 5416: 5367: 5314: 5281: 5225: 4812:Int J Environ Res Public Health 4773: 4686:"Assessment scales in dementia" 4623: 4589: 4552: 4515: 4489: 4458:"Dementia – Signs and Symptoms" 4450: 4423: 3767: 3387: 3371: 3043:often a mixture of conditions. 3038:By the 1960s, the link between 2994:In 1907, Bavarian psychiatrist 2821:needs additional citations for 2796:early-onset Alzheimer's disease 2565: 2515:is unclear. It is not clear if 2234:Acetylcholinesterase inhibitors 2089:Acetylcholinesterase inhibitors 2083:Caring for people with dementia 1975: 1797: 1638:integrated cognitive assessment 693: 677: 562:Acetylcholinesterase inhibitors 252:, no smoking, social engagement 18212:Dissociative identity disorder 17477:Adult personality and behavior 14418:10.1002/14651858.cd006440.pub3 14320:Birch D, Draper J (May 2008). 14166:International Psychogeriatrics 14126:10.1002/14651858.CD012820.pub2 14077:10.1002/14651858.CD003150.pub3 14028:10.1002/14651858.CD004989.pub2 13903:10.1002/14651858.cd009627.pub2 13859:Smith M, Robinson L, Segal J. 13828:10.1002/14651858.CD006489.pub4 13779:10.1002/14651858.cd011077.pub2 13557:10.1002/14651858.CD007209.pub2 12899:10.1002/14651858.CD009178.pub4 12843:10.1002/14651858.CD011881.pub2 12701:10.1002/14651858.CD011971.pub2 12637:10.1002/14651858.CD007514.pub3 12595:10.1002/14651858.CD004514.pub2 12560:10.1002/14651858.CD008191.pub2 12519:10.1002/14651858.CD003944.pub2 12171:10.1002/14651858.CD007726.pub2 11635:International Psychogeriatrics 11460:10.1002/14651858.CD009812.pub3 11411:10.1002/14651858.CD013388.pub2 11362:10.1002/14651858.cd011961.pub2 11079:10.1002/14651858.CD003477.pub4 11026:International Psychogeriatrics 10891:10.1002/14651858.CD010515.pub2 10841:10.1002/14651858.CD005562.pub2 10759:10.1002/14651858.CD005318.pub2 10708:10.1002/14651858.CD001120.pub3 10566:Journal of Applied Gerontology 10358:10.1002/14651858.CD006489.pub4 10309:10.1002/14651858.CD011513.pub3 10108:10.1002/14651858.CD013572.pub2 10010:10.1002/14651858.CD009002.pub3 8783:Journal of Alzheimer's Disease 8219:10.1002/14651858.CD011333.pub3 8160:International Psychogeriatrics 8077:10.1002/14651858.CD011121.pub2 7851:International Psychogeriatrics 6928:International Psychogeriatrics 4232:Handbook of Clinical Neurology 4199:10.1002/14651858.CD009125.pub3 3598: 3539:10.1002/14651858.CD011145.pub2 3485: 3384:have been proposed as of 2020. 3090: 2217: 2210:Personally tailored activities 1412:progressive supranuclear palsy 1132:progressive supranuclear palsy 1034: 755:MCI has been relisted in both 585:of dementia are termed as the 343:disruption in thought patterns 13: 1: 17408:Amyotrophic lateral sclerosis 17293:Hereditary spastic paraplegia 17151:Normal pressure hydrocephalus 16443: 16020:Garvey M (October 22, 2020). 15979:Thompson S (September 2010). 15684:10.1080/13607863.2020.1753014 15187:10.1016/s0197-4580(98)00052-9 14866:Sadock BJ, Sadock VA (2008). 14771:Clinics in Geriatric Medicine 14689:10.1016/s0140-6736(16)31012-1 14642:"World Alzheimer Report 2009" 14609:"World Alzheimer Report 2015" 14526:10.1016/S2468-2667(21)00249-8 13645:10.1016/S0899-9007(97)00030-0 13506:Archives of Internal Medicine 11872:10.1016/S0140-6736(15)00462-6 11758:10.1001/archinternmed.2009.43 11745:Archives of Internal Medicine 8648:10.1016/S1474-4422(19)30393-X 7911:10.1016/S0887-6177(03)00039-8 6414:10.1016/S1474-4422(19)30153-X 6020:10.1080/14789450.2021.1918550 5426:. National Institute on Aging 5189:Clinics in Geriatric Medicine 3743:10.1016/S1474-4422(18)30403-4 3659:10.1016/S0140-6736(20)30367-6 3401: 3246:Everywhere at the End of Time 2656:Disability-adjusted life year 2076: 2060:non-celiac gluten sensitivity 1786: 1750:normal pressure hydrocephalus 1630:Montreal Cognitive Assessment 1614:abbreviated mental test score 1610:mini mental state examination 1349:non-celiac gluten sensitivity 1275: 1128:amyotrophic lateral sclerosis 1124:amyotrophic lateral sclerosis 865:normal pressure hydrocephalus 773:mini–mental state examination 543:mini–mental state examination 222:mini–mental state examination 18616:Pseudoneurotic schizophrenia 18153:Generalized anxiety disorder 17886:Neurological and symptomatic 17531:Sexual relationship disorder 17377:Progressive muscular atrophy 15824:Boseley S (March 26, 2012). 14640:Prince M, Jackson J (2009). 14571:10.1016/j.amjmed.2018.01.022 14484:"The top 10 causes of death" 14180:(inactive August 26, 2024). 13978:10.1371/journal.pdig.0000053 13160:10.1016/j.ejpain.2006.08.001 13073:10.1097/AJP.0b013e31802be869 13061:The Clinical Journal of Pain 12261:10.1097/WAD.0b013e31816653bc 11972:10.1212/CON.0000000000000309 11649:(inactive August 26, 2024). 11589:Health Technology Assessment 10153:Journal of Internal Medicine 9607:10.1016/j.neuint.2010.12.003 9595:Neurochemistry International 9506:Journal of Oral Microbiology 7649:10.1212/CPJ.0000000000000566 7637:Neurology. Clinical Practice 6516:10.1212/CON.0000000000000300 6467:10.1212/CON.0000000000000309 6360:10.1212/WNL.0000000000004058 6269:10.1212/WNL.0000000000009323 6152:10.1016/j.neuron.2013.10.008 6134:Iadecola C (November 2013). 5325:, Warren JD (January 2008). 4649:10.1371/journal.pmed.1001505 4559:Casselman B (May 31, 2024). 3938:Budson A, Solomon P (2011). 3876:10.1212/WNL.0000000000009323 3289:, professional skateboarder 3278:Academy Award Winning actor 1728:. Abnormalities may suggest 1652:for its commercial use as a 1463: 1083:Parkinson's disease dementia 1005:disease of the blood vessels 869:Parkinson's disease dementia 854:Many causes of dementia are 721: 413:Parkinson's disease dementia 405:neurodevelopmental disorders 7: 18392:REM sleep behavior disorder 17861:Seasonal affective disorder 17659:Separation anxiety disorder 16887:Primary progressive aphasia 16051:Ezra M (October 23, 2020). 15987:(Thesis). pp. 372–381. 15282:Bratislavske lekarske listy 15222:. 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December 2017. 8967:Current Psychiatry Reports 8429:10.1176/appi.ajgp.12.6.554 8264:10.1016/j.jalz.2007.07.011 8252:Alzheimer's & Dementia 8038:10.3310/nihrevidence_59137 7892:Tombaugh TN (March 2004). 7355:10.1016/j.mcna.2010.08.004 6860:10.1016/bs.irn.2019.09.002 6500:"Frontotemporal Dementias" 6449:Gomperts SN (April 2016). 5892:10.1007/s40266-018-00636-7 5723:10.1016/j.jalz.2019.04.002 5710:Alzheimer's & Dementia 5643:Alzheimer's & Dementia 5201:10.1016/j.cger.2014.04.001 5158:10.1016/j.mcna.2018.10.009 4875:10.1007/s00441-020-03367-7 4609:10.3310/nihrevidence_51255 4050:10.1007/s00702-019-01975-4 3120:(precocious dementia) and 3040:neurodegenerative diseases 2863: 2801: 2786: 2464: 2398: 2112: 2080: 1801: 1790: 1735: 1523: 1514:Geriatric Depression Scale 1279: 1257: 1191: 1152:Huntington's disease is a 1145: 1092: 1064:autonomic bodily functions 1038: 982: 890: 732:mild behavioral impairment 315:neurodegenerative diseases 62: 53: 19051:Aging-associated diseases 18738: 18664: 18653: 18629: 18621:Simple-type schizophrenia 18598: 18590:Schizophreniform disorder 18567: 18546: 18542: 18521: 18474: 18456: 18425: 18402: 18356: 18323: 18319: 18308: 18230: 18197: 18145: 18088: 18079: 18060: 18056: 18035: 18001: 17968:Mild cognitive impairment 17953:Creutzfeldt–Jakob disease 17933: 17895: 17891: 17880: 17851:Major depressive disorder 17804: 17790: 17756:Psychological development 17755: 17730: 17627: 17623: 17610: 17539: 17486: 17482: 17471: 17315:Spinal muscular atrophies 17283:Primary lateral sclerosis 17265: 17242: 17226: 17181: 17141:Intracranial hypertension 17131: 17103: 17074: 17040: 17002: 16991: 16957: 16935: 16921:Creutzfeldt–Jakob disease 16860: 16670: 16661: 16647: 16607: 16541: 16393: 16284: 16159:Rogers K (July 1, 2022). 15671:Aging & Mental Health 15484:. 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Public Health 14178:10.1017/S1041610205001018 12738:Internal Medicine Journal 12370:10.1007/s40267-018-0537-8 11922:10.1186/s13195-015-0128-z 11708:10.1002/14651858.CD005593 11647:10.1017/S1041610209990354 11547:Annual Review of Medicine 11315:10.1024/1662-9647/a000225 11191:10.1186/s12877-016-0250-1 11039:10.1017/S1041610217002344 10806:10.1002/14651858.CD001394 10578:10.1177/07334648211028692 9781:10.1007/s12035-015-9516-4 9028:10.1007/s00106-019-0617-7 8979:10.1007/s11920-016-0721-2 8746:10.1016/j.arr.2021.101269 8530:10.1016/j.jad.2022.07.008 8367:Clinical Nuclear Medicine 8340:American Family Physician 8172:10.1017/S1041610204000390 7863:10.1017/S1041610294001602 7382:American Family Physician 7376:Gleason OC (March 2003). 7279:10.1186/s12877-015-0064-6 7142:10.1016/j.jns.2009.08.034 7099:10.1007/s13760-017-0870-z 7057:10.1007/s11940-019-0552-7 7044:Curr Treat Options Neurol 7000:10.1007/s11910-009-0053-2 6940:10.1017/s1041610205001997 6902:"What is mixed dementia?" 6639:10.1007/s13311-013-0244-z 6436:Courtesty link available 6086:Frontiers in Neuroscience 5817:10.1007/978-4-431-55948-1 5773:10.1007/s00018-018-2854-4 5556:10.1007/s12603-018-1033-5 5506:10.1007/s11910-017-0734-1 5459:10.1007/s11910-016-0684-z 5290:Dementia care at a glance 4920:10.1017/S1041610217000527 4497:"What Is Dementia? | CDC" 4381:"Inhibition in Cognition" 3829:10.1016/j.arr.2019.100956 3382:dementia with Lewy bodies 2880:hardening of the arteries 2749:World Health Organization 2363:, and non-benzodiazepine 1416:corticobasal degeneration 1404:dementia with Lewy bodies 1260:Creutzfeldt–Jakob disease 1254:Creutzfeldt–Jakob disease 1154:neurodegenerative disease 1136:corticobasal degeneration 1115:Two types of FTD feature 1081:that often progresses to 1047:mild cognitive impairment 1041:Dementia with Lewy bodies 991:blood supply to the brain 915:word-finding difficulties 881:Creutzfeldt–Jakob disease 849: 800: 791:dementia with Lewy bodies 728:mild cognitive impairment 688:mild cognitive impairment 664: 587:neuropsychiatric symptoms 449:dementia with Lewy bodies 296: 288: 278: 268: 256: 244: 228: 211: 201: 178: 174:Varies, usually long term 170: 162: 145: 127: 111: 103: 94: 90:Senility, senile dementia 86: 81: 69:Demented (disambiguation) 56:Dementia (disambiguation) 18922:Motor vehicle collisions 18669:Impulse-control disorder 18585:Schizoaffective disorder 18580:Brief reactive psychosis 18277:Mass psychogenic illness 18240:Body dysmorphic disorder 18019:Post-concussion syndrome 17629:Emotional and behavioral 17382:Progressive bulbar palsy 17173:Intracranial hypotension 17156:Choroid plexus papilloma 16570:Herpesviral encephalitis 16456:templates for discussion 14288:10.1177/0269216313493685 13148:European Journal of Pain 11960:Continuum (Minneap Minn) 11265:10.5014/ajot.2020.040782 11136:10.1177/1471301214556291 10348:(Submitted manuscript). 9563:10.1038/sj.bdj.2017.1064 9463:10.3389/fnagi.2015.00046 9085:10.1177/2040622318811000 7600:10.1136/jnnp.2006.095414 6763:10.1136/jnnp.2004.048660 6745:Collinge J (July 2005). 6621:Frank S (January 2014). 6498:Finger EC (April 2016). 6455:Continuum (Minneap Minn) 6099:10.3389/fnins.2010.00272 5108:10.1177/1178646919877883 4780:Scharre DW (June 2019). 4702:10.1177/1756285612455733 4038:J Neural Transm (Vienna) 3998:"What is mixed dementia" 3364: 2985:cerebral atherosclerosis 2773:Global Burden of Disease 2204:cognitive rehabilitation 1434:protein deposits in the 1370:gluten-related disorders 1314: 1282:Alcohol-related dementia 1171:difficulty concentrating 936:(shrinking) include the 932:. Other parts that show 919:visuospatial functioning 766: 672:Clinical Dementia Rating 488:nutritional deficiencies 31:latest accepted revision 18606:Childhood schizophrenia 17958:Frontotemporal dementia 17915:High-functioning autism 17732:Intellectual disability 16894:Frontotemporal dementia 16580:Encephalitis lethargica 16489:Alzheimer's Association 16117:Alzheimer's Association 15436:Dementia Statistics Hub 13359:: an initiative of the 13320:: an initiative of the 12062:: an initiative of the 11966:(2 Dementia): 435–463. 11827:: an initiative of the 9684:10.23750/abm.v89i2.7401 9415:10.1038/sj.bdj.2017.992 8734:Ageing Research Reviews 8312:10.1093/geront/39.4.457 7228:10.1001/jama.2019.12232 6720:Clinical Neuropathology 6510:(2 Dementia): 464–489. 6461:(2 Dementia): 435–463. 5068:10.1126/science.aaf9794 3944:. : Elsevier Saunders. 3817:Ageing Research Reviews 3697:Prescrire International 3243:'s last music release, 3160:multi-infarct dementias 3155:organic brain syndromes 3076:other types of dementia 3025:neurofibrillary tangles 2394: 2183:Animal-assisted therapy 2021:unsaturated fatty acids 1994: 1989:neurofibrillary tangles 1757:functional neuroimaging 1458:spinocerebellar ataxias 1366:strict gluten-free diet 1362:frontotemporal dementia 1321:inflammatory conditions 1095:Frontotemporal dementia 954:neurofibrillary tangles 948:the gene that produces 832:swallowing difficulties 813: 795:frontotemporal dementia 441:frontotemporal dementia 300:2.4 million (2016) 195:frontotemporal dementia 166:Varies, usually gradual 65:Senile (disambiguation) 18771:Cardiovascular disease 18123:Specific social phobia 18014:Organic brain syndrome 17856:Melancholic depression 17617:Childhood and learning 17199:Hepatic encephalopathy 15132:Psychological Medicine 15098:10.3390/ijerph18157899 14376:10.7748/ns.30.7.46.s47 13687:10.1001/jama.2016.9374 12993:10.1055/s-0039-1683408 9769:Molecular Neurobiology 9551:British Dental Journal 9403:British Dental Journal 9314:10.1001/jama.2020.4249 9180:10.1055/s-0038-1660779 9010:Dawes P (March 2019). 8697:10.1001/jama.2019.9879 6934:(Suppl 1): S129–S147. 5944:10.1001/jama.2019.4782 5237:dementia-directive.org 4825:10.3390/ijerph18136976 4337:Noro Psikiyatri Arsivi 3234:Trinity College Dublin 3205:Mental Health Act 1983 3184: 2915:Athenian philosophers 2890: 2744: 2648: 2255:Medications that have 2230: 1793:Prevention of dementia 1438:portion of the brain. 1422:). Although the acute 1232:central nervous system 1187: 1102:behavioral variant FTD 911:short-term memory loss 906: 527:history of the illness 512:neurological disorders 230:Differential diagnosis 19066:Learning disabilities 18949:Risky sexual behavior 18733:of medical conditions 18679:Psychomotor agitation 18469:and substance-related 18412:Postpartum depression 18292:Somatization disorder 18178:Acute stress reaction 17943:AIDS dementia complex 17257:Ataxia–telangiectasia 17214:Static encephalopathy 16937:Mitochondrial disease 16775:Spasmodic torticollis 16685:Basal ganglia disease 16192:. September 22, 2004. 16003:Philanthropy magazine 15398:Archives of Neurology 14247:10.1093/eurpub/cku084 14203:on February 24, 2019. 12981:Seminars in Neurology 12469:10.1093/ageing/afw053 11856:"Lewy body dementias" 11788:. Elsevier BV: 1–14. 11510:10.1186/1741-7015-7-7 10963:(1): 13–18, quiz 19. 10542:1959.4/unsworks_39417 9941:Omar SH (June 2019). 8927:10.1093/geronb/gbx087 8636:The Lancet. Neurology 7312:"Dementia definition" 6314:10.1684/pnv.2018.0723 5139:Atri A (March 2019). 4349:10.5152/npa.2014.7405 3731:The Lancet. Neurology 3282:, Editor-in-Chief of 3249:, was popularized by 3179: 3074:In the 21st century, 3046:In 1976, neurologist 2888: 2654: 2573: 2465:Further information: 2228: 1962:. Six oral treponema 1842:vascular risk factors 1777:Pittsburgh compound B 905:in severe Alzheimer's 900: 780:word-finding problems 627:visuospatial function 313:associated with many 18939:Periodontal diseases 18674:Klüver–Bucy syndrome 18504:Substance dependence 18417:Postpartum psychosis 17963:Huntington's disease 17745:Lujan–Fryns syndrome 17594:Personality disorder 17204:Toxic encephalopathy 16910:Lewy bodies dementia 15050:10.1038/nrdp.2015.56 14913:10.4088/PCC.24m03724 14683:(10053): 1459–1544. 14648:: 38. Archived from 13590:The American Surgeon 13024:Ugeskrift for Laeger 12664:on September 3, 2019 11866:(10004): 1683–1697. 9960:10.3390/ijms20112797 9518:10.3402/jom.v7.29143 9078:: 2040622318811000. 8032:. February 8, 2023. 7349:(6): 1103–1116, ix. 5343:10.1093/brain/awm251 5102:: 1178646919877883. 5096:Int J Tryptophan Res 3110:By 1913–20 the term 2830:improve this article 2789:Early onset dementia 2560:digital surveillance 2544:Person-centered care 2503:Alternative medicine 2496:assistive technology 2490:Assistive technology 2443:aspiration pneumonia 2177:reminiscence therapy 2121:reminiscence therapy 1981:Herpes simplex virus 1526:Cognitive inhibition 1482:cognitive impairment 1442:Hereditary disorders 1296:alcohol use disorder 1148:Huntington's disease 1142:Huntington's disease 844:paradoxical lucidity 782:, and problems with 708:olfactory epithelium 655:urinary incontinence 603:cognitive inhibition 417:Huntington's disease 153:aspiration pneumonia 19056:Cognitive disorders 18554:Delusional disorder 18499:Stimulant psychosis 18489:Physical dependence 18343:Rumination syndrome 18245:Conversion disorder 18222:Psychogenic amnesia 18072:with depressed mood 18070:Adjustment disorder 17973:Parkinson's disease 17948:Alzheimer's disease 17841:Atypical depression 17677:Social functioning 17552:Munchausen syndrome 17547:Factitious disorder 17252:Friedreich's ataxia 16635:Meningoencephalitis 16575:Limbic encephalitis 16475:web.s.ebscohost.com 16140:. February 13, 2023 15999:"Tackling dementia" 15977:Also published in: 15644:10.3310/alert_40575 15482:"What is dementia?" 14275:Palliative Medicine 13965:PLOS Digital Health 13111:The Journal of Pain 13067:(1 Suppl): S1–S43. 11909:Alzheimers Res Ther 10620:10.3310/alert_42713 9444:Miklossy J (2015). 8888:10.3310/alert_40330 8484:10.3390/jpm10020020 6906:Alzheimer's Society 6800:Alzheimers Res Ther 6677:. February 16, 2018 5975:Gauthier S (2006). 5683:Alzheimer's Society 4786:Practical Neurology 4503:. December 19, 2019 4010:on November 1, 2020 3172:Society and culture 3147:Alzheimer's disease 3126:precocious dementia 2966:William Shakespeare 2426:Eating difficulties 2162:Alzheimer's Society 2125:cognitive reframing 1969:blood–brain barrier 1873:physical inactivity 1810:high blood pressure 1775:-PET imaging using 1536: 1446:metabolic disorders 1408:Alzheimer's disease 1400:Parkinson's disease 1292:thiamine deficiency 1242:, abnormalities of 1220:Histopathologically 1160:, that encodes for 1077:is associated with 1075:Parkinson's disease 1070:Parkinson's disease 1017:atrial fibrillation 1013:high blood pressure 893:Alzheimer's disease 887:Alzheimer's disease 836:Alzheimer's disease 784:executive functions 740:is a metabolite of 712:blood–brain barrier 636:high blood pressure 589:—also known as the 500:metabolic disorders 476:endocrine disorders 409:Parkinson's disease 378:Alzheimer's disease 319:everyday activities 183:Alzheimer's disease 21:Page version status 18905:Metabolic syndrome 18573:schizophrenia-like 18217:Dissociative fugue 17666:Movement disorders 17288:Pseudobulbar palsy 17026:Status epilepticus 16977:Multiple sclerosis 16814:Myoclonic epilepsy 16677:movement disorders 16623:Acute disseminated 16565:Viral encephalitis 16394:External resources 16093:. November 2, 2020 16060:The New York Times 15371:The New York Times 14738:10.1002/trc2.12222 14455:The New York Times 13732:The New York Times 12053:(September 2013), 10926:. London: Arnold. 10660:10.3310/pgfar08060 10165:10.1111/joim.12191 9748:. January 15, 2019 8795:10.3233/JAD-210364 7430:10.2147/CIA.S63504 5061:(6349): eaaf9794. 5018:10.1002/trc2.12016 4761:. January 29, 2014 4566:The New York Times 3653:(10248): 413–446. 3185: 3165:vascular dementias 3017:Bielschowsky stain 2891: 2745: 2649: 2346:Sleep disturbances 2231: 2200:cognitive training 2129:validation therapy 2070:Omega-3 fatty acid 2017:blood sugar levels 1730:vitamin deficiency 1706:C-reactive protein 1626:clock drawing test 1534: 1337:Sjögren's syndrome 1329:multiple sclerosis 1106:impulsive behavior 1079:Lewy body dementia 907: 860:protein misfolding 746:kynurenine pathway 659:fecal incontinence 583:signs and symptoms 577:Signs and symptoms 520:multiple sclerosis 27: 18992: 18991: 18979:Teenage pregnancy 18865:Domestic violence 18860:Diabetes mellitus 18696: 18695: 18692: 18691: 18649: 18648: 18645: 18644: 18517: 18516: 18452: 18451: 18448: 18447: 18304: 18303: 18300: 18299: 18193: 18192: 18031: 18030: 18027: 18026: 17988:Vascular dementia 17910:Asperger syndrome 17876: 17875: 17786: 17785: 17782: 17781: 17720:Tourette syndrome 17606: 17605: 17602: 17601: 17426: 17425: 17422: 17421: 17418: 17417: 17222: 17221: 17127: 17126: 17066:Template:Headache 17032:Template:Epilepsy 16953: 16952: 16927:Vascular dementia 16770:Status dystonicus 16643: 16642: 16618:Encephalomyelitis 16439: 16438: 15887:10.1136/bmj.j3445 15365:(June 17, 2010). 14964:alzheimers.org.uk 14939:alzheimers.org.uk 14881:978-0-7817-8746-8 14652:on March 11, 2012 14565:(10): 1161–1169. 13393:(10): 1918–1921. 13350:(February 2014), 13311:(February 2014), 13030:(40): 3429–3432. 12800:10.1002/jppr.1403 12750:10.1111/imj.13215 12744:(10): 1189–1197. 12317:10.1111/cns.13095 11818:(February 2014), 10933:978-0-340-81026-2 10922:Barker P (2003). 10527:(11): 1007–1016. 10448:10.1159/000445883 10249:(12): 1277–1288. 10059:10.1002/wps.20672 9841:10.3390/nu8030144 9308:(19): 1934–1944. 8454:on July 13, 2020. 8299:The Gerontologist 7995:10.1111/jgs.18241 7743:(19): 1588–1595. 7724:on June 26, 2010. 7493:JAMA Network Open 7473:978-0-7693-0015-3 6869:978-0-12-817530-9 6627:Neurotherapeutics 6590:10.1111/ane.12546 6578:Acta Neurol Scand 6061:(Suppl 9): 7–10. 5988:978-0-203-93171-4 5938:(16): 1589–1599. 5826:978-4-431-55948-1 5767:(17): 3159–3180. 5761:Cell Mol Life Sci 5649:(10): 1367–1377. 5299:978-1-118-85998-8 5274:978-0-89042-554-1 5145:Med Clin North Am 4908:Int Psychogeriatr 4603:. June 21, 2022. 4436:Psychiatric Times 4249:978-0-12-804766-8 4098:978-0-89042-554-1 3951:978-1-4160-3597-8 3618:978-1-58562-257-3 3605:Hales RE (2008). 3280:Samuel L. Jackson 3239:In October 2020, 2899:Greek philosopher 2862: 2861: 2854: 2742: 2741: 2646: 2645: 2355:recommended that 2269:blockers such as 1885:cognitive reserve 1881:neural plasticity 1854:conscientiousness 1660:this sort is the 1622:Trail-making test 1602: 1601: 1520:Cognitive testing 985:Vascular dementia 856:neurodegenerative 840:terminal lucidity 838:. In some cases, 634:present, such as 531:cognitive testing 472:subdural hematoma 457:synucleinopathies 445:Lewy body disease 425:vascular dementia 339:memory impairment 304: 303: 292:55 million (2021) 218:Cognitive testing 213:Diagnostic method 191:Lewy body disease 187:vascular dementia 76:Medical condition 18: 19078: 19033: 19032: 19031: 19021: 19020: 19009: 19008: 19007: 19000: 18910:Mental disorders 18723: 18716: 18709: 18700: 18699: 18655: 18654: 18544: 18543: 18523: 18522: 18458: 18457: 18333:Anorexia nervosa 18321: 18320: 18310: 18309: 18287:Psychogenic pain 18255:Globus pharyngis 18103:Childhood phobia 18086: 18085: 18058: 18057: 18037: 18036: 17893: 17892: 17882: 17881: 17792: 17791: 17691:Selective mutism 17642:Conduct disorder 17625: 17624: 17612: 17611: 17589:Trichotillomania 17564:Gender dysphoria 17559:Fear of intimacy 17516:Sexual anhedonia 17484: 17483: 17473: 17472: 17460:Mental disorders 17453: 17446: 17439: 17430: 17429: 17240: 17239: 17231: 17230: 17189:Brain herniation 17000: 16999: 16840:Intention tremor 16835:Essential tremor 16700:Postencephalitic 16668: 16667: 16659: 16658: 16548: 16547: 16529:Diseases of the 16523: 16516: 16509: 16500: 16499: 16485: 16483: 16481: 16282: 16281: 16270: 16269: 16267: 16265: 16251: 16245: 16244: 16242: 16240: 16225: 16219: 16218: 16216: 16214: 16200: 16194: 16193: 16182: 16176: 16175: 16173: 16171: 16156: 16150: 16149: 16147: 16145: 16134: 16128: 16127: 16125: 16123: 16109: 16103: 16102: 16100: 16098: 16083: 16077: 16076: 16074: 16072: 16056: 16048: 16042: 16041: 16039: 16037: 16017: 16011: 16010: 15995: 15989: 15988: 15976: 15964: 15958: 15957: 15946: 15940: 15939: 15937: 15935: 15921: 15915: 15914: 15870: 15864: 15863: 15861: 15859: 15821: 15815: 15814: 15812: 15810: 15796: 15790: 15789: 15787: 15785: 15779: 15772: 15764: 15758: 15757: 15721: 15715: 15714: 15696: 15686: 15677:(7): 1232–1238. 15662: 15656: 15655: 15628: 15622: 15621: 15611: 15579: 15573: 15572: 15570: 15568: 15562:Psychology Today 15554: 15548: 15547: 15545: 15543: 15529: 15523: 15522: 15517: 15515: 15503: 15497: 15496: 15491: 15489: 15478: 15472: 15471: 15469: 15467: 15453: 15447: 15446: 15444: 15442: 15428: 15422: 15421: 15393: 15387: 15386: 15384: 15382: 15359: 15353: 15352: 15342: 15310: 15289: 15288:(9–10), 343–345. 15278: 15267: 15266: 15251:Xihua J (1989). 15248: 15242: 15241: 15213: 15207: 15206: 15170: 15164: 15163: 15127: 15121: 15120: 15110: 15100: 15076: 15070: 15069: 15033: 15024: 15023: 15013: 14981: 14975: 14974: 14972: 14970: 14956: 14950: 14949: 14947: 14945: 14931: 14925: 14924: 14892: 14886: 14885: 14863: 14854: 14853: 14843: 14833: 14809: 14803: 14802: 14766: 14760: 14759: 14749: 14717: 14711: 14710: 14700: 14668: 14662: 14661: 14659: 14657: 14637: 14631: 14630: 14628: 14626: 14620: 14613: 14604: 14591: 14590: 14554: 14548: 14547: 14537: 14520:(2): e105–e125. 14505: 14499: 14498: 14496: 14494: 14480: 14474: 14473: 14471: 14469: 14446: 14440: 14439: 14429: 14397: 14388: 14387: 14364:Nursing Standard 14359: 14353: 14352: 14335:(9): 1144–1163. 14326: 14317: 14311: 14310: 14300: 14290: 14266: 14260: 14259: 14249: 14225: 14219: 14218: 14212: 14204: 14202: 14196:. Archived from 14163: 14154: 14148: 14147: 14137: 14105: 14099: 14098: 14088: 14056: 14050: 14049: 14039: 14007: 14001: 14000: 13990: 13980: 13956: 13950: 13949: 13947: 13945: 13931: 13925: 13924: 13914: 13882: 13876: 13875: 13873: 13871: 13856: 13850: 13849: 13839: 13807: 13801: 13800: 13790: 13758: 13749: 13748: 13746: 13744: 13722: 13716: 13715: 13713: 13698: 13672: 13663: 13657: 13656: 13628: 13622: 13621: 13585: 13579: 13578: 13568: 13536: 13530: 13529: 13501: 13495: 13492: 13463: 13453: 13420: 13410: 13376: 13375: 13373: 13344: 13338: 13337: 13336: 13334: 13305: 13299: 13298: 13262: 13256: 13255: 13245: 13221: 13215: 13214: 13186: 13180: 13179: 13143: 13137: 13136: 13126: 13102: 13093: 13092: 13055: 13040: 13039: 13019: 13013: 13012: 12976: 12970: 12969: 12959: 12927: 12921: 12920: 12910: 12893:(11): CD009178. 12878: 12865: 12864: 12854: 12822: 12813: 12812: 12802: 12778: 12772: 12771: 12761: 12729: 12723: 12722: 12712: 12695:(11): CD011971. 12680: 12674: 12673: 12671: 12669: 12663: 12657:. Archived from 12648: 12622: 12613: 12607: 12606: 12578: 12572: 12571: 12547: 12541: 12540: 12530: 12498: 12492: 12491: 12481: 12471: 12447: 12441: 12440: 12430: 12398: 12392: 12391: 12381: 12345: 12339: 12338: 12328: 12296: 12283: 12282: 12272: 12240: 12234: 12233: 12223: 12199: 12193: 12192: 12182: 12156: 12147: 12141: 12140: 12116: 12110: 12109: 12107: 12105: 12090: 12084: 12083: 12082: 12080: 12047: 12041: 12040: 12038: 12036: 12013: 11994: 11993: 11983: 11951: 11945: 11944: 11934: 11924: 11903:Boot BP (2015). 11900: 11894: 11893: 11883: 11851: 11845: 11844: 11843: 11841: 11812: 11806: 11805: 11777: 11771: 11770: 11760: 11736: 11730: 11729: 11719: 11687: 11681: 11680: 11674: 11666: 11629: 11623: 11622: 11612: 11601:10.3310/hta16210 11580: 11571: 11570: 11542: 11533: 11532: 11522: 11512: 11488: 11482: 11481: 11471: 11439: 11433: 11432: 11422: 11390: 11384: 11383: 11373: 11341: 11335: 11334: 11294: 11285: 11284: 11248: 11239: 11238: 11236: 11234: 11220: 11214: 11213: 11203: 11193: 11169: 11158: 11157: 11147: 11130:(6): 1326–1339. 11115: 11109: 11108: 11098: 11058: 11052: 11051: 11041: 11017: 11008: 11007: 10984:Nursing Standard 10979: 10973: 10972: 10952: 10946: 10945: 10919: 10913: 10912: 10902: 10870: 10861: 10860: 10824: 10818: 10817: 10793: 10787: 10786: 10752: 10743:(11): CD005318. 10736: 10730: 10729: 10719: 10687: 10681: 10680: 10662: 10638: 10632: 10631: 10604: 10598: 10597: 10572:(4): 1196–1208. 10561: 10555: 10554: 10544: 10512: 10506: 10505: 10476: 10470: 10469: 10459: 10427: 10421: 10420: 10410: 10389:Camp CJ (2010). 10386: 10380: 10379: 10369: 10337: 10331: 10330: 10320: 10288: 10275: 10274: 10255:10.1002/gps.4504 10237: 10231: 10230: 10211:10.7326/M19-0993 10193: 10187: 10186: 10176: 10144: 10138: 10137: 10119: 10102:(11): CD013572. 10087: 10081: 10080: 10070: 10047:World Psychiatry 10038: 10032: 10031: 10021: 9989: 9983: 9982: 9972: 9962: 9938: 9932: 9931: 9913: 9903: 9878: 9872: 9871: 9861: 9843: 9815: 9809: 9808: 9775:(9): 6144–6154. 9764: 9758: 9757: 9755: 9753: 9738: 9732: 9731: 9729: 9727: 9712: 9706: 9705: 9695: 9663: 9654: 9651: 9645: 9642: 9636: 9633: 9627: 9626: 9589: 9583: 9582: 9546: 9540: 9539: 9529: 9497: 9486: 9485: 9475: 9465: 9441: 9435: 9434: 9400: 9391: 9385: 9384: 9374: 9342: 9336: 9335: 9325: 9293: 9287: 9286: 9267:10.7326/M17-1529 9249: 9243: 9242: 9206: 9200: 9199: 9163: 9157: 9156: 9146: 9114: 9108: 9107: 9097: 9087: 9063: 9050: 9049: 9039: 9007: 9001: 9000: 8990: 8958: 8949: 8948: 8938: 8906: 8900: 8899: 8872: 8866: 8865: 8855: 8844:10.1002/gps.5304 8823: 8817: 8816: 8806: 8774: 8768: 8767: 8757: 8725: 8719: 8718: 8708: 8676: 8670: 8669: 8659: 8627: 8621: 8620: 8618: 8616: 8610: 8603: 8595: 8589: 8588: 8569:10.1002/gps.4790 8563:(2): e286–e293. 8548: 8542: 8541: 8513: 8507: 8506: 8496: 8486: 8462: 8456: 8455: 8453: 8447:. Archived from 8414: 8405: 8399: 8398: 8362: 8356: 8355: 8346:(6): 1358–1366. 8331: 8325: 8324: 8314: 8290: 8284: 8283: 8247: 8241: 8240: 8230: 8198: 8192: 8191: 8155: 8149: 8148: 8146: 8144: 8130: 8121: 8120: 8118: 8116: 8105: 8099: 8098: 8088: 8056: 8050: 8049: 8022: 8016: 8015: 7997: 7988:(5): 1485–1494. 7973: 7967: 7966: 7930: 7924: 7923: 7913: 7889: 7883: 7882: 7845: 7839: 7838: 7818: 7812: 7811: 7775: 7769: 7768: 7732: 7726: 7725: 7723: 7717:. Archived from 7700: 7691: 7685: 7677: 7671: 7670: 7660: 7628: 7622: 7621: 7611: 7579: 7570: 7569: 7533: 7527: 7526: 7516: 7499:(12): e2136553. 7484: 7478: 7477: 7459: 7453: 7452: 7442: 7432: 7408: 7402: 7401: 7388:(5): 1027–1034. 7373: 7367: 7366: 7338: 7332: 7331: 7329: 7327: 7308: 7302: 7301: 7291: 7281: 7257: 7248: 7247: 7211: 7205: 7204: 7179:(9): 1605–1611. 7168: 7162: 7161: 7125: 7119: 7118: 7087:Acta Neurol Belg 7081: 7070: 7069: 7059: 7035: 7022: 7021: 7011: 6979: 6970: 6969: 6951: 6923: 6917: 6916: 6914: 6912: 6898: 6892: 6891: 6881: 6847: 6836: 6835: 6825: 6815: 6813:10.1186/alzrt157 6791: 6785: 6784: 6774: 6742: 6736: 6735: 6714: 6708: 6707: 6696: 6687: 6686: 6684: 6682: 6667: 6661: 6660: 6650: 6618: 6612: 6611: 6601: 6569: 6563: 6562: 6560: 6558: 6544: 6538: 6537: 6527: 6495: 6489: 6488: 6478: 6446: 6440: 6435: 6425: 6393: 6382: 6381: 6371: 6339: 6326: 6325: 6297: 6291: 6290: 6280: 6248: 6242: 6241: 6239: 6237: 6223: 6217: 6216: 6180: 6174: 6173: 6163: 6131: 6122: 6121: 6111: 6101: 6077: 6071: 6070: 6049:Wenk GL (2003). 6046: 6040: 6039: 6003: 5997: 5996: 5972: 5966: 5965: 5955: 5923: 5914: 5913: 5903: 5871: 5865: 5864: 5862: 5860: 5845: 5839: 5838: 5801: 5795: 5794: 5784: 5752: 5746: 5745: 5735: 5725: 5716:(8): 1107–1114. 5701: 5695: 5694: 5692: 5690: 5675: 5669: 5668: 5658: 5634: 5628: 5627: 5625: 5610: 5592: 5583: 5577: 5576: 5558: 5534: 5528: 5527: 5517: 5485: 5479: 5478: 5442: 5436: 5435: 5433: 5431: 5420: 5414: 5413: 5403: 5371: 5365: 5364: 5354: 5318: 5312: 5311: 5285: 5279: 5278: 5254: 5248: 5247: 5245: 5243: 5229: 5223: 5222: 5212: 5180: 5171: 5170: 5160: 5136: 5130: 5129: 5119: 5087: 5081: 5080: 5070: 5046: 5040: 5039: 5029: 4996: 4987: 4986: 4967:10.1002/gps.5016 4949: 4940: 4939: 4903: 4897: 4896: 4886: 4854: 4848: 4847: 4837: 4827: 4803: 4797: 4796: 4794: 4792: 4777: 4771: 4770: 4768: 4766: 4751: 4745: 4744: 4742: 4740: 4730: 4724: 4723: 4713: 4681: 4672: 4671: 4661: 4651: 4627: 4621: 4620: 4593: 4587: 4586: 4580: 4578: 4573:on June 30, 2024 4569:. Archived from 4556: 4550: 4549: 4547: 4545: 4539:10.59576/sr.1106 4528: 4519: 4513: 4512: 4510: 4508: 4493: 4487: 4486: 4484: 4482: 4468: 4462: 4461: 4454: 4448: 4447: 4427: 4421: 4420: 4418: 4416: 4402: 4396: 4395: 4393: 4391: 4377: 4371: 4370: 4360: 4328: 4319: 4318: 4308: 4297:10.1136/bmj.h369 4276: 4270: 4269: 4227: 4221: 4220: 4210: 4178: 4172: 4171: 4161: 4137: 4128: 4127: 4125: 4123: 4109: 4103: 4102: 4078: 4072: 4071: 4061: 4029: 4020: 4019: 4017: 4015: 4006:. Archived from 3994: 3981: 3980: 3978: 3976: 3962: 3956: 3955: 3935: 3898: 3897: 3887: 3855: 3849: 3848: 3814: 3805: 3790: 3789: 3787: 3785: 3771: 3765: 3764: 3754: 3722: 3713: 3712: 3692: 3681: 3680: 3670: 3638: 3627: 3626: 3602: 3596: 3595: 3593: 3591: 3577: 3571: 3570: 3560: 3550: 3518: 3509: 3508: 3506: 3504: 3489: 3483: 3482: 3480: 3478: 3464: 3431: 3430: 3428: 3426: 3412: 3395: 3391: 3385: 3375: 3347:Maureen McGovern 3118:dementia praecox 3113:dementia praecox 2866:Dementia praecox 2857: 2850: 2846: 2843: 2837: 2814: 2806: 2761:apolipoprotein E 2757:African American 2735: 2729: 2723: 2717: 2711: 2705: 2697: 2691: 2685: 2679: 2673: 2667: 2661: 2639: 2633: 2627: 2621: 2615: 2607: 2601: 2595: 2589: 2583: 2577: 2485: 2484: 2480: 2477: 2133:mental exercises 2064:gluten-free diet 1893:social isolation 1877:aerobic exercise 1710:full blood count 1681:Laboratory tests 1537: 1498:mental illnesses 1454:leukodystrophies 1353:immunomodulators 1325:Behçet's disease 1021:high cholesterol 704:this dysfunction 632:other conditions 508:leukodystrophies 421:vascular disease 349:, and decreased 99: 79: 78: 39:7 September 2024 19086: 19085: 19081: 19080: 19079: 19077: 19076: 19075: 19041: 19040: 19039: 19029: 19027: 19015: 19005: 19003: 18995: 18993: 18988: 18734: 18727: 18697: 18688: 18660: 18641: 18625: 18594: 18572: 18563: 18538: 18513: 18470: 18467:substance abuse 18444: 18421: 18398: 18352: 18338:Bulimia nervosa 18315: 18296: 18272:Hypochondriasis 18267:False pregnancy 18250:Ganser syndrome 18232:Somatic symptom 18226: 18189: 18141: 18130:Specific phobia 18075: 18052: 18023: 17997: 17929: 17925:Savant syndrome 17897:Autism spectrum 17887: 17872: 17800: 17778: 17757: 17751: 17726: 17619: 17598: 17574:Dermatillomania 17535: 17521:Sexual anorexia 17478: 17467: 17457: 17427: 17414: 17340:Congenital DSMA 17261: 17218: 17177: 17123: 17111:Sleep disorders 17099: 17076:Cerebrovascular 17070: 17036: 16993: 16987: 16949: 16931: 16856: 16802:Choreoathetosis 16675: 16652: 16639: 16603: 16537: 16527: 16479: 16477: 16469: 16459: 16440: 16435: 16434: 16389: 16388: 16293: 16279: 16274: 16273: 16263: 16261: 16253: 16252: 16248: 16238: 16236: 16235:. July 21, 2023 16227: 16226: 16222: 16212: 16210: 16202: 16201: 16197: 16184: 16183: 16179: 16169: 16167: 16157: 16153: 16143: 16141: 16136: 16135: 16131: 16121: 16119: 16111: 16110: 16106: 16096: 16094: 16085: 16084: 16080: 16070: 16068: 16049: 16045: 16035: 16033: 16018: 16014: 16005:. Winter 2016. 15997: 15996: 15992: 15965: 15961: 15948: 15947: 15943: 15933: 15931: 15923: 15922: 15918: 15871: 15867: 15857: 15855: 15822: 15818: 15808: 15806: 15798: 15797: 15793: 15783: 15781: 15780:on May 18, 2012 15777: 15770: 15766: 15765: 15761: 15722: 15718: 15663: 15659: 15630: 15629: 15625: 15580: 15576: 15566: 15564: 15556: 15555: 15551: 15541: 15539: 15531: 15530: 15526: 15513: 15511: 15504: 15500: 15487: 15485: 15480: 15479: 15475: 15465: 15463: 15455: 15454: 15450: 15440: 15438: 15430: 15429: 15425: 15394: 15390: 15380: 15378: 15360: 15356: 15311: 15292: 15279: 15270: 15263: 15249: 15245: 15230: 15214: 15210: 15175:Neurobiol Aging 15171: 15167: 15128: 15124: 15077: 15073: 15034: 15027: 14982: 14978: 14968: 14966: 14958: 14957: 14953: 14943: 14941: 14933: 14932: 14928: 14893: 14889: 14882: 14864: 14857: 14810: 14806: 14767: 14763: 14718: 14714: 14669: 14665: 14655: 14653: 14638: 14634: 14624: 14622: 14618: 14611: 14605: 14594: 14555: 14551: 14506: 14502: 14492: 14490: 14482: 14481: 14477: 14467: 14465: 14447: 14443: 14412:(1): CD006440. 14398: 14391: 14360: 14356: 14324: 14318: 14314: 14267: 14263: 14226: 14222: 14206: 14205: 14200: 14161: 14155: 14151: 14120:(9): CD012820. 14106: 14102: 14071:(8): CD003150. 14057: 14053: 14022:(4): CD004989. 14008: 14004: 13971:(6): e0000053. 13957: 13953: 13943: 13941: 13933: 13932: 13928: 13897:(6): CD009627. 13883: 13879: 13869: 13867: 13857: 13853: 13822:(4): CD006489. 13808: 13804: 13773:(9): CD011077. 13759: 13752: 13742: 13740: 13723: 13719: 13711: 13670: 13664: 13660: 13629: 13625: 13586: 13582: 13551:(2): CD007209. 13537: 13533: 13502: 13498: 13377:, which cites: 13371: 13369: 13361:ABIM Foundation 13357:Choosing Wisely 13345: 13341: 13332: 13330: 13322:ABIM Foundation 13318:Choosing Wisely 13306: 13302: 13263: 13259: 13222: 13218: 13187: 13183: 13144: 13140: 13103: 13096: 13056: 13043: 13020: 13016: 12977: 12973: 12928: 12924: 12879: 12868: 12837:(1): CD011881. 12823: 12816: 12779: 12775: 12730: 12726: 12681: 12677: 12667: 12665: 12661: 12631:(7): CD007514. 12620: 12614: 12610: 12589:(4): CD004514. 12583:Grimley Evans J 12579: 12575: 12554:(2): CD008191. 12548: 12544: 12513:(8): CD003944. 12499: 12495: 12448: 12444: 12399: 12395: 12346: 12342: 12297: 12286: 12241: 12237: 12200: 12196: 12180:1854/LU-3109108 12165:(3): CD007726. 12154: 12148: 12144: 12131:(12): 884–889. 12117: 12113: 12103: 12101: 12100:. June 20, 2018 12092: 12091: 12087: 12078: 12076: 12064:ABIM Foundation 12060:Choosing Wisely 12048: 12044: 12034: 12032: 12014: 11997: 11952: 11948: 11901: 11897: 11852: 11848: 11839: 11837: 11829:ABIM Foundation 11825:Choosing Wisely 11813: 11809: 11778: 11774: 11737: 11733: 11702:(1): CD005593. 11688: 11684: 11668: 11667: 11630: 11626: 11581: 11574: 11543: 11536: 11489: 11485: 11454:(3): CD009812. 11440: 11436: 11405:(6): CD013388. 11391: 11387: 11356:(2): CD011961. 11342: 11338: 11295: 11288: 11249: 11242: 11232: 11230: 11222: 11221: 11217: 11170: 11161: 11116: 11112: 11073:(7): CD003477. 11059: 11055: 11018: 11011: 10980: 10976: 10957:Medsurg Nursing 10953: 10949: 10934: 10920: 10916: 10885:(8): CD010515. 10871: 10864: 10835:(2): CD005562. 10825: 10821: 10800:(3): CD001394. 10794: 10790: 10737: 10733: 10702:(3): CD001120. 10688: 10684: 10639: 10635: 10606: 10605: 10601: 10562: 10558: 10513: 10509: 10477: 10473: 10428: 10424: 10387: 10383: 10352:(4): CD006489. 10338: 10334: 10303:(9): CD011513. 10289: 10278: 10238: 10234: 10194: 10190: 10145: 10141: 10088: 10084: 10039: 10035: 10004:(4): CD009002. 9990: 9986: 9939: 9935: 9879: 9875: 9816: 9812: 9765: 9761: 9751: 9749: 9740: 9739: 9735: 9725: 9723: 9713: 9709: 9664: 9657: 9652: 9648: 9643: 9639: 9634: 9630: 9590: 9586: 9548: 9547: 9543: 9498: 9489: 9442: 9438: 9409:(11): 846–853. 9398: 9392: 9388: 9357:(10): e045186. 9343: 9339: 9294: 9290: 9250: 9246: 9207: 9203: 9164: 9160: 9135:10.1002/lio2.65 9115: 9111: 9064: 9053: 9008: 9004: 8959: 8952: 8907: 8903: 8874: 8873: 8869: 8824: 8820: 8775: 8771: 8726: 8722: 8677: 8673: 8628: 8624: 8614: 8612: 8608: 8601: 8597: 8596: 8592: 8549: 8545: 8518:J Affect Disord 8514: 8510: 8463: 8459: 8451: 8412: 8406: 8402: 8363: 8359: 8332: 8328: 8291: 8287: 8248: 8244: 8213:(7): CD011333. 8199: 8195: 8156: 8152: 8142: 8140: 8132: 8131: 8124: 8114: 8112: 8106: 8102: 8071:(3): CD011121. 8057: 8053: 8024: 8023: 8019: 7974: 7970: 7931: 7927: 7890: 7886: 7846: 7842: 7819: 7815: 7776: 7772: 7733: 7729: 7721: 7698: 7692: 7688: 7678: 7674: 7629: 7625: 7580: 7573: 7544:(11): 927–937. 7534: 7530: 7485: 7481: 7474: 7460: 7456: 7411:Lai CK (2014). 7409: 7405: 7374: 7370: 7339: 7335: 7325: 7323: 7310: 7309: 7305: 7258: 7251: 7222:(10): 914–916. 7212: 7208: 7169: 7165: 7126: 7122: 7082: 7073: 7036: 7025: 6980: 6973: 6924: 6920: 6910: 6908: 6900: 6899: 6895: 6870: 6848: 6839: 6792: 6788: 6743: 6739: 6715: 6711: 6698: 6697: 6690: 6680: 6678: 6669: 6668: 6664: 6619: 6615: 6570: 6566: 6556: 6554: 6546: 6545: 6541: 6496: 6492: 6447: 6443: 6394: 6385: 6340: 6329: 6298: 6294: 6263:(17): 743–755. 6249: 6245: 6235: 6233: 6225: 6224: 6220: 6191:(11): 887–891. 6181: 6177: 6132: 6125: 6078: 6074: 6047: 6043: 6004: 6000: 5989: 5973: 5969: 5924: 5917: 5872: 5868: 5858: 5856: 5847: 5846: 5842: 5827: 5802: 5798: 5753: 5749: 5702: 5698: 5688: 5686: 5685:. June 29, 2022 5677: 5676: 5672: 5635: 5631: 5623: 5590: 5584: 5580: 5535: 5531: 5486: 5482: 5443: 5439: 5429: 5427: 5422: 5421: 5417: 5372: 5368: 5319: 5315: 5300: 5286: 5282: 5275: 5255: 5251: 5241: 5239: 5231: 5230: 5226: 5181: 5174: 5137: 5133: 5088: 5084: 5047: 5043: 4997: 4990: 4950: 4943: 4904: 4900: 4863:Cell Tissue Res 4855: 4851: 4804: 4800: 4790: 4788: 4778: 4774: 4764: 4762: 4753: 4752: 4748: 4738: 4736: 4732: 4731: 4727: 4682: 4675: 4642:(8): e1001505. 4628: 4624: 4595: 4594: 4590: 4576: 4574: 4557: 4553: 4543: 4541: 4526: 4520: 4516: 4506: 4504: 4495: 4494: 4490: 4480: 4478: 4470: 4469: 4465: 4456: 4455: 4451: 4428: 4424: 4414: 4412: 4410:medlineplus.gov 4404: 4403: 4399: 4389: 4387: 4379: 4378: 4374: 4329: 4322: 4277: 4273: 4250: 4228: 4224: 4193:(4): CD009125. 4179: 4175: 4138: 4131: 4121: 4119: 4111: 4110: 4106: 4099: 4079: 4075: 4030: 4023: 4013: 4011: 3996: 3995: 3984: 3974: 3972: 3964: 3963: 3959: 3952: 3936: 3901: 3870:(17): 743–755. 3856: 3852: 3812: 3806: 3793: 3783: 3781: 3773: 3772: 3768: 3723: 3716: 3693: 3684: 3639: 3630: 3619: 3603: 3599: 3589: 3587: 3579: 3578: 3574: 3533:(1): CD011145. 3519: 3512: 3502: 3500: 3491: 3490: 3486: 3476: 3474: 3466: 3465: 3434: 3424: 3422: 3420:medlineplus.gov 3414: 3413: 3409: 3404: 3399: 3398: 3392: 3388: 3376: 3372: 3367: 3174: 3097:senile dementia 3093: 3048:Robert Katzmann 2996:Alois Alzheimer 2989:cerebral cortex 2910:Chinese medical 2868: 2858: 2847: 2841: 2838: 2827: 2815: 2804: 2791: 2785: 2753:Hispanic/Latino 2743: 2737: 2733: 2731: 2727: 2725: 2721: 2719: 2715: 2713: 2709: 2707: 2703: 2699: 2695: 2693: 2689: 2687: 2683: 2681: 2677: 2675: 2671: 2669: 2665: 2647: 2641: 2637: 2635: 2631: 2629: 2625: 2623: 2619: 2617: 2613: 2609: 2605: 2603: 2599: 2597: 2593: 2591: 2587: 2585: 2581: 2568: 2552: 2529:palliative care 2525: 2523:Palliative care 2505: 2492: 2482: 2478: 2475: 2473: 2469: 2463: 2447:pressure ulcers 2428: 2419:quality of life 2407: 2397: 2357:benzodiazepines 2348: 2324: 2298:antidepressants 2257:anticholinergic 2242:slow heart rate 2220: 2212: 2196: 2173:Life story work 2117: 2111: 2085: 2079: 1997: 1985:amyloid plaques 1978: 1928: 1920: 1858:purpose in life 1806: 1800: 1795: 1789: 1738: 1694: 1683: 1606:cognitive tests 1532: 1522: 1510:pseudodementias 1466: 1384: 1317: 1304: 1284: 1278: 1262: 1256: 1196: 1190: 1150: 1144: 1097: 1091: 1072: 1043: 1037: 987: 981: 917:. Trouble with 895: 889: 852: 816: 808:lack of insight 803: 769: 724: 696: 680: 667: 623:problem solving 579: 262:supportive care 157:akinetic mutism 77: 72: 59: 52: 47: 46: 45: 44: 43: 42: 26: 12: 11: 5: 19084: 19074: 19073: 19068: 19063: 19058: 19053: 19038: 19037: 19025: 19013: 18990: 18989: 18987: 18986: 18981: 18976: 18971: 18966: 18961: 18956: 18951: 18946: 18941: 18936: 18935: 18934: 18924: 18919: 18918: 18917: 18907: 18902: 18897: 18892: 18887: 18882: 18877: 18872: 18867: 18862: 18857: 18852: 18851: 18850: 18840: 18835: 18834: 18833: 18828: 18823: 18818: 18813: 18808: 18803: 18798: 18793: 18788: 18783: 18773: 18768: 18766:Binge drinking 18763: 18758: 18753: 18748: 18742: 18740: 18736: 18735: 18726: 18725: 18718: 18711: 18703: 18694: 18693: 18690: 18689: 18687: 18686: 18681: 18676: 18671: 18665: 18662: 18661: 18651: 18650: 18647: 18646: 18643: 18642: 18640: 18639: 18633: 18631: 18627: 18626: 18624: 18623: 18618: 18613: 18608: 18602: 18600: 18596: 18595: 18593: 18592: 18587: 18582: 18576: 18574: 18565: 18564: 18562: 18561: 18556: 18550: 18548: 18540: 18539: 18519: 18518: 18515: 18514: 18512: 18511: 18506: 18501: 18496: 18494:Rebound effect 18491: 18486: 18481: 18475: 18472: 18471: 18454: 18453: 18450: 18449: 18446: 18445: 18443: 18442: 18437: 18435:Hypersexuality 18431: 18429: 18423: 18422: 18420: 18419: 18414: 18408: 18406: 18400: 18399: 18397: 18396: 18395: 18394: 18389: 18384: 18374: 18369: 18363: 18361: 18354: 18353: 18351: 18350: 18345: 18340: 18335: 18329: 18327: 18317: 18316: 18306: 18305: 18302: 18301: 18298: 18297: 18295: 18294: 18289: 18284: 18279: 18274: 18269: 18264: 18263: 18262: 18257: 18252: 18242: 18236: 18234: 18228: 18227: 18225: 18224: 18219: 18214: 18209: 18203: 18201: 18195: 18194: 18191: 18190: 18188: 18187: 18186: 18185: 18180: 18170: 18168:Panic disorder 18165: 18160: 18155: 18149: 18147: 18143: 18142: 18140: 18139: 18138: 18137: 18135:Claustrophobia 18127: 18126: 18125: 18120: 18118:Anthropophobia 18110: 18108:Social anxiety 18105: 18100: 18094: 18092: 18083: 18077: 18076: 18074: 18073: 18066: 18064: 18054: 18053: 18033: 18032: 18029: 18028: 18025: 18024: 18022: 18021: 18016: 18011: 18005: 18003: 17999: 17998: 17996: 17995: 17990: 17985: 17980: 17978:Pick's disease 17975: 17970: 17965: 17960: 17955: 17950: 17945: 17939: 17937: 17931: 17930: 17928: 17927: 17922: 17917: 17912: 17907: 17901: 17899: 17889: 17888: 17878: 17877: 17874: 17873: 17871: 17870: 17865: 17864: 17863: 17858: 17853: 17848: 17843: 17833: 17832: 17831: 17826: 17821: 17816: 17805: 17802: 17801: 17788: 17787: 17784: 17783: 17780: 17779: 17777: 17776: 17771: 17765: 17763: 17753: 17752: 17750: 17749: 17748: 17747: 17736: 17734: 17728: 17727: 17725: 17724: 17723: 17722: 17712: 17711: 17710: 17705: 17695: 17694: 17693: 17688: 17683: 17675: 17674: 17673: 17663: 17662: 17661: 17651: 17650: 17649: 17639: 17633: 17631: 17621: 17620: 17608: 17607: 17604: 17603: 17600: 17599: 17597: 17596: 17591: 17586: 17581: 17576: 17571: 17566: 17561: 17556: 17555: 17554: 17543: 17541: 17537: 17536: 17534: 17533: 17528: 17523: 17518: 17513: 17512: 17511: 17506: 17496: 17490: 17488: 17480: 17479: 17469: 17468: 17464:Classification 17456: 17455: 17448: 17441: 17433: 17424: 17423: 17420: 17419: 17416: 17415: 17413: 17412: 17411: 17410: 17399: 17398: 17397: 17396: 17395: 17394: 17389: 17379: 17374: 17373: 17372: 17367: 17362: 17361: 17360: 17355: 17350: 17342: 17337: 17332: 17327: 17322: 17312: 17298: 17297: 17296: 17295: 17290: 17285: 17271: 17269: 17263: 17262: 17260: 17259: 17254: 17248: 17246: 17237: 17228: 17224: 17223: 17220: 17219: 17217: 17216: 17211: 17206: 17201: 17196: 17191: 17185: 17183: 17179: 17178: 17176: 17175: 17170: 17168:Cerebral edema 17165: 17164: 17163: 17158: 17153: 17148: 17137: 17135: 17129: 17128: 17125: 17124: 17122: 17121: 17120: 17119: 17117:Template:Sleep 17107: 17105: 17101: 17100: 17098: 17097: 17091: 17086: 17080: 17078: 17072: 17071: 17069: 17068: 17062: 17057: 17052: 17046: 17044: 17038: 17037: 17035: 17034: 17028: 17023: 17018: 17012: 17010: 16997: 16989: 16988: 16986: 16985: 16979: 16974: 16969: 16963: 16961: 16955: 16954: 16951: 16950: 16948: 16947: 16945:Leigh syndrome 16941: 16939: 16933: 16932: 16930: 16929: 16918: 16917: 16912: 16907: 16906: 16905: 16891: 16890: 16889: 16884: 16883: 16882: 16866: 16864: 16858: 16857: 16855: 16854: 16849: 16844: 16843: 16842: 16837: 16826: 16825: 16824: 16823: 16818: 16817: 16816: 16806: 16805: 16804: 16794: 16789: 16788: 16787: 16782: 16777: 16772: 16756: 16755: 16754: 16753: 16748: 16743: 16738: 16733: 16732: 16731: 16721: 16720: 16719: 16709: 16708: 16707: 16702: 16697: 16681: 16679: 16672:Extrapyramidal 16665: 16656: 16654:encephalopathy 16645: 16644: 16641: 16640: 16638: 16637: 16632: 16627: 16626: 16625: 16614: 16612: 16605: 16604: 16602: 16601: 16600: 16599: 16589: 16584: 16583: 16582: 16577: 16572: 16567: 16556: 16554: 16545: 16539: 16538: 16531:nervous system 16526: 16525: 16518: 16511: 16503: 16497: 16496: 16491: 16486: 16467: 16437: 16436: 16433: 16432: 16421: 16419:article/793247 16410: 16398: 16397: 16395: 16391: 16390: 16387: 16386: 16375: 16364: 16345: 16322: 16294: 16289: 16288: 16286: 16285:Classification 16278: 16277:External links 16275: 16272: 16271: 16246: 16220: 16195: 16177: 16151: 16129: 16104: 16078: 16043: 16012: 15990: 15959: 15941: 15916: 15865: 15816: 15791: 15759: 15732:(4): 483–491. 15716: 15657: 15623: 15594:(2): 217–228. 15574: 15549: 15524: 15498: 15473: 15448: 15423: 15404:(4): 217–218. 15388: 15354: 15325:(4): 115–121. 15290: 15268: 15261: 15243: 15228: 15208: 15181:(3): 173–189. 15165: 15138:(4): 829–837. 15122: 15071: 15025: 14976: 14951: 14926: 14887: 14880: 14855: 14804: 14761: 14712: 14663: 14632: 14592: 14549: 14500: 14475: 14441: 14389: 14354: 14312: 14281:(3): 197–209. 14261: 14240:(5): 705–706. 14220: 14149: 14100: 14051: 14002: 13951: 13939:Alzheimers.net 13926: 13877: 13851: 13802: 13750: 13717: 13681:(7): 769–770. 13658: 13639:(6): 520–523. 13623: 13596:(2): 117–120. 13580: 13531: 13512:(3): 327–332. 13496: 13494: 13493: 13475:(5): 364–367. 13464: 13436:(3): 580–584. 13421: 13339: 13300: 13273:(2): 319–326. 13257: 13236:(2): 170–192. 13216: 13197:(8): 371–375. 13181: 13154:(5): 564–571. 13138: 13117:(5): 373–378. 13094: 13041: 13014: 12987:(2): 167–178. 12971: 12942:(4): 616–631. 12922: 12866: 12814: 12793:(4): 356–367. 12773: 12724: 12675: 12608: 12573: 12542: 12493: 12462:(4): 448–456. 12456:Age and Ageing 12442: 12413:(37): e22209. 12393: 12364:(8): 358–366. 12340: 12311:(2): 288–298. 12284: 12255:(3): 209–221. 12235: 12214:(5): 379–397. 12194: 12142: 12111: 12085: 12042: 11995: 11946: 11895: 11846: 11807: 11772: 11751:(9): 867–873. 11731: 11682: 11641:(5): 813–824. 11624: 11572: 11553:(1): 513–533. 11534: 11483: 11434: 11385: 11336: 11286: 11240: 11215: 11178:BMC Geriatrics 11159: 11110: 11053: 11032:(3): 295–309. 11009: 10974: 10947: 10932: 10914: 10862: 10819: 10788: 10731: 10682: 10633: 10599: 10556: 10507: 10488:(8): 784–793. 10471: 10442:(2): 268–275. 10422: 10401:(2): 163–174. 10381: 10332: 10276: 10232: 10205:(9): 633–642. 10188: 10159:(3): 251–283. 10139: 10082: 10053:(3): 308–324. 10033: 9984: 9933: 9873: 9810: 9759: 9733: 9707: 9678:(2): 276–290. 9655: 9646: 9637: 9628: 9601:(3): 301–320. 9584: 9541: 9487: 9436: 9386: 9337: 9288: 9244: 9201: 9174:(3): 197–210. 9158: 9109: 9051: 9022:(3): 165–171. 9002: 8950: 8921:(1): 114–124. 8901: 8867: 8838:(7): 794–801. 8818: 8789:(1): 249–258. 8769: 8720: 8691:(5): 430–437. 8671: 8622: 8590: 8543: 8508: 8457: 8423:(6): 554–570. 8400: 8373:(7): 376–378. 8357: 8326: 8305:(4): 457–464. 8285: 8258:(4): 299–317. 8242: 8193: 8166:(3): 275–293. 8150: 8122: 8100: 8051: 8017: 7968: 7941:(4): 695–699. 7925: 7904:(2): 203–214. 7884: 7840: 7829:(8): 314–318. 7813: 7786:(5): 411–419. 7770: 7727: 7686: 7672: 7643:(2): 109–117. 7623: 7594:(8): 790–799. 7571: 7528: 7479: 7472: 7454: 7403: 7368: 7333: 7318:. Reed Group. 7303: 7249: 7206: 7163: 7136:(1–2): 18–22. 7120: 7071: 7023: 6994:(5): 359–367. 6971: 6918: 6893: 6868: 6837: 6786: 6757:(7): 906–919. 6737: 6726:(4): 146–155. 6709: 6688: 6662: 6633:(1): 153–160. 6613: 6584:(4): 242–249. 6564: 6539: 6490: 6441: 6408:(2): 157–169. 6383: 6327: 6292: 6243: 6218: 6175: 6146:(4): 844–866. 6123: 6072: 6041: 6014:(4): 295–304. 5998: 5987: 5967: 5915: 5886:(4): 309–319. 5866: 5840: 5825: 5807:, ed. (2017). 5796: 5747: 5733:2027.42/153062 5696: 5670: 5629: 5601:(2): 196–201. 5578: 5549:(5): 562–565. 5529: 5480: 5437: 5415: 5386:(2): 131–137. 5366: 5337:(Pt 1): 8–38. 5313: 5298: 5280: 5273: 5249: 5224: 5195:(3): 421–442. 5172: 5151:(2): 263–293. 5131: 5082: 5041: 4988: 4961:(2): 233–242. 4941: 4914:(2): 177–184. 4898: 4869:(1): 559–567. 4849: 4798: 4772: 4746: 4725: 4696:(6): 349–358. 4673: 4622: 4588: 4551: 4514: 4488: 4463: 4449: 4422: 4397: 4372: 4343:(4): 303–312. 4320: 4271: 4248: 4222: 4173: 4152:(9): 601–612. 4129: 4104: 4097: 4073: 4044:(3): 233–251. 4021: 3982: 3957: 3950: 3899: 3850: 3791: 3766: 3714: 3682: 3628: 3617: 3597: 3572: 3510: 3497:mayoclinic.org 3484: 3432: 3406: 3405: 3403: 3400: 3397: 3396: 3386: 3369: 3368: 3366: 3363: 3362: 3361: 3349: 3343: 3337: 3332:Wendy Williams 3328: 3322: 3316: 3310: 3308:Robin Williams 3304: 3293:, and others. 3173: 3170: 3092: 3089: 3033:Emil Kraepelin 3021:senile plaques 3007:succumbing to 2948:Constantinople 2860: 2859: 2818: 2816: 2809: 2803: 2800: 2784: 2781: 2740: 2739: 2732: 2726: 2720: 2714: 2708: 2702: 2700: 2694: 2688: 2682: 2676: 2670: 2664: 2659: 2644: 2643: 2640: 376–1266 2636: 2630: 2624: 2618: 2612: 2610: 2604: 2598: 2592: 2586: 2580: 2575: 2567: 2564: 2551: 2548: 2524: 2521: 2504: 2501: 2491: 2488: 2462: 2459: 2427: 2424: 2396: 2393: 2347: 2344: 2322: 2277:An extract of 2219: 2216: 2211: 2208: 2195: 2192: 2113:Main article: 2110: 2107: 2081:Main article: 2078: 2075: 2056:celiac disease 2054:In those with 1996: 1993: 1977: 1974: 1927: 1924: 1919: 1916: 1799: 1796: 1791:Main article: 1788: 1785: 1759:modalities of 1737: 1734: 1722:renal function 1692: 1682: 1679: 1654:medical device 1604:Various brief 1600: 1599: 1597: 1594: 1591: 1585: 1584: 1582: 1579: 1576: 1570: 1569: 1567: 1564: 1561: 1555: 1554: 1551: 1546: 1541: 1521: 1518: 1506:differentiated 1470:brain scanning 1465: 1462: 1382: 1377:hypothyroidism 1345:celiac disease 1316: 1313: 1303: 1302:Mixed dementia 1300: 1280:Main article: 1277: 1274: 1258:Main article: 1255: 1252: 1246:processes and 1240:myelin sheaths 1192:Main article: 1189: 1186: 1185: 1184: 1181: 1178: 1175: 1172: 1146:Main article: 1143: 1140: 1093:Main article: 1090: 1089:Frontotemporal 1087: 1071: 1068: 1039:Main article: 1036: 1033: 983:Main article: 980: 977: 942:parietal lobes 891:Main article: 888: 885: 851: 848: 815: 812: 802: 799: 768: 765: 723: 720: 700:sense of smell 695: 692: 679: 676: 666: 663: 607:hallucinations 578: 575: 560:for dementia. 480:hypothyroidism 465:mixed dementia 453:prion diseases 395:subtypes. The 302: 301: 298: 294: 293: 290: 286: 285: 282: 276: 275: 272: 266: 265: 258: 254: 253: 246: 242: 241: 239:hypothyroidism 232: 226: 225: 215: 209: 208: 205: 199: 198: 180: 176: 175: 172: 168: 167: 164: 160: 159: 151:Malnutrition, 149: 143: 142: 131: 125: 124: 115: 109: 108: 101: 100: 92: 91: 88: 84: 83: 75: 50: 28: 22: 19: 17: 9: 6: 4: 3: 2: 19083: 19072: 19069: 19067: 19064: 19062: 19059: 19057: 19054: 19052: 19049: 19048: 19046: 19036: 19026: 19024: 19019: 19014: 19012: 19002: 19001: 18998: 18985: 18982: 18980: 18977: 18975: 18972: 18970: 18967: 18965: 18962: 18960: 18957: 18955: 18954:Schizophrenia 18952: 18950: 18947: 18945: 18942: 18940: 18937: 18933: 18930: 18929: 18928: 18925: 18923: 18920: 18916: 18913: 18912: 18911: 18908: 18906: 18903: 18901: 18898: 18896: 18893: 18891: 18888: 18886: 18883: 18881: 18878: 18876: 18873: 18871: 18868: 18866: 18863: 18861: 18858: 18856: 18853: 18849: 18846: 18845: 18844: 18841: 18839: 18836: 18832: 18829: 18827: 18824: 18822: 18819: 18817: 18814: 18812: 18809: 18807: 18804: 18802: 18799: 18797: 18794: 18792: 18789: 18787: 18784: 18782: 18779: 18778: 18777: 18774: 18772: 18769: 18767: 18764: 18762: 18759: 18757: 18754: 18752: 18749: 18747: 18744: 18743: 18741: 18737: 18732: 18724: 18719: 18717: 18712: 18710: 18705: 18704: 18701: 18685: 18682: 18680: 18677: 18675: 18672: 18670: 18667: 18666: 18663: 18656: 18652: 18638: 18635: 18634: 18632: 18628: 18622: 18619: 18617: 18614: 18612: 18609: 18607: 18604: 18603: 18601: 18599:Schizophrenia 18597: 18591: 18588: 18586: 18583: 18581: 18578: 18577: 18575: 18570: 18566: 18560: 18557: 18555: 18552: 18551: 18549: 18545: 18541: 18537: 18533: 18529: 18528:Schizophrenia 18524: 18520: 18510: 18507: 18505: 18502: 18500: 18497: 18495: 18492: 18490: 18487: 18485: 18482: 18480: 18479:Drug overdose 18477: 18476: 18473: 18468: 18464: 18459: 18455: 18441: 18438: 18436: 18433: 18432: 18430: 18428: 18427:Sexual desire 18424: 18418: 18415: 18413: 18410: 18409: 18407: 18405: 18401: 18393: 18390: 18388: 18385: 18383: 18380: 18379: 18378: 18375: 18373: 18370: 18368: 18365: 18364: 18362: 18360: 18355: 18349: 18346: 18344: 18341: 18339: 18336: 18334: 18331: 18330: 18328: 18326: 18322: 18318: 18311: 18307: 18293: 18290: 18288: 18285: 18283: 18280: 18278: 18275: 18273: 18270: 18268: 18265: 18261: 18258: 18256: 18253: 18251: 18248: 18247: 18246: 18243: 18241: 18238: 18237: 18235: 18233: 18229: 18223: 18220: 18218: 18215: 18213: 18210: 18208: 18205: 18204: 18202: 18200: 18196: 18184: 18181: 18179: 18176: 18175: 18174: 18171: 18169: 18166: 18164: 18161: 18159: 18156: 18154: 18151: 18150: 18148: 18144: 18136: 18133: 18132: 18131: 18128: 18124: 18121: 18119: 18116: 18115: 18114: 18113:Social phobia 18111: 18109: 18106: 18104: 18101: 18099: 18096: 18095: 18093: 18091: 18087: 18084: 18082: 18078: 18071: 18068: 18067: 18065: 18063: 18059: 18055: 18051: 18048:-related and 18047: 18043: 18038: 18034: 18020: 18017: 18015: 18012: 18010: 18007: 18006: 18004: 18000: 17994: 17991: 17989: 17986: 17984: 17981: 17979: 17976: 17974: 17971: 17969: 17966: 17964: 17961: 17959: 17956: 17954: 17951: 17949: 17946: 17944: 17941: 17940: 17938: 17936: 17932: 17926: 17923: 17921: 17918: 17916: 17913: 17911: 17908: 17906: 17903: 17902: 17900: 17898: 17894: 17890: 17883: 17879: 17869: 17866: 17862: 17859: 17857: 17854: 17852: 17849: 17847: 17844: 17842: 17839: 17838: 17837: 17834: 17830: 17827: 17825: 17822: 17820: 17817: 17815: 17812: 17811: 17810: 17807: 17806: 17803: 17798: 17793: 17789: 17775: 17772: 17770: 17767: 17766: 17764: 17761: 17754: 17746: 17743: 17742: 17741: 17738: 17737: 17735: 17733: 17729: 17721: 17718: 17717: 17716: 17713: 17709: 17706: 17704: 17701: 17700: 17699: 17696: 17692: 17689: 17687: 17684: 17682: 17679: 17678: 17676: 17672: 17669: 17668: 17667: 17664: 17660: 17657: 17656: 17655: 17652: 17648: 17645: 17644: 17643: 17640: 17638: 17635: 17634: 17632: 17630: 17626: 17622: 17618: 17613: 17609: 17595: 17592: 17590: 17587: 17585: 17582: 17580: 17577: 17575: 17572: 17570: 17567: 17565: 17562: 17560: 17557: 17553: 17550: 17549: 17548: 17545: 17544: 17542: 17538: 17532: 17529: 17527: 17524: 17522: 17519: 17517: 17514: 17510: 17507: 17505: 17502: 17501: 17500: 17497: 17495: 17492: 17491: 17489: 17485: 17481: 17474: 17470: 17465: 17461: 17454: 17449: 17447: 17442: 17440: 17435: 17434: 17431: 17409: 17406: 17405: 17404: 17401: 17400: 17393: 17390: 17388: 17385: 17384: 17383: 17380: 17378: 17375: 17371: 17368: 17366: 17363: 17359: 17356: 17354: 17351: 17349: 17346: 17345: 17343: 17341: 17338: 17336: 17333: 17331: 17328: 17326: 17323: 17321: 17318: 17317: 17316: 17313: 17311: 17308: 17307: 17306: 17304: 17300: 17299: 17294: 17291: 17289: 17286: 17284: 17281: 17280: 17279: 17277: 17273: 17272: 17270: 17268: 17264: 17258: 17255: 17253: 17250: 17249: 17247: 17245: 17241: 17238: 17236: 17232: 17229: 17225: 17215: 17212: 17210: 17207: 17205: 17202: 17200: 17197: 17195: 17194:Reye syndrome 17192: 17190: 17187: 17186: 17184: 17180: 17174: 17171: 17169: 17166: 17162: 17159: 17157: 17154: 17152: 17149: 17147: 17146:Hydrocephalus 17144: 17143: 17142: 17139: 17138: 17136: 17134: 17130: 17118: 17114: 17113: 17112: 17109: 17108: 17106: 17102: 17096: 17092: 17090: 17087: 17085: 17082: 17081: 17079: 17077: 17073: 17067: 17063: 17061: 17058: 17056: 17053: 17051: 17048: 17047: 17045: 17043: 17039: 17033: 17029: 17027: 17024: 17022: 17019: 17017: 17014: 17013: 17011: 17009: 17005: 17001: 16998: 16996: 16990: 16984: 16980: 16978: 16975: 16973: 16970: 16968: 16965: 16964: 16962: 16960: 16959:Demyelinating 16956: 16946: 16943: 16942: 16940: 16938: 16934: 16928: 16925: 16924: 16923: 16922: 16916: 16913: 16911: 16908: 16904: 16901: 16900: 16899: 16895: 16892: 16888: 16885: 16881: 16878: 16877: 16876: 16873: 16872: 16871: 16868: 16867: 16865: 16863: 16859: 16853: 16850: 16848: 16847:Restless legs 16845: 16841: 16838: 16836: 16833: 16832: 16831: 16828: 16827: 16822: 16819: 16815: 16812: 16811: 16810: 16807: 16803: 16800: 16799: 16798: 16795: 16793: 16790: 16786: 16785:Blepharospasm 16783: 16781: 16778: 16776: 16773: 16771: 16768: 16767: 16766: 16763: 16762: 16761: 16758: 16757: 16752: 16749: 16747: 16744: 16742: 16741:Hemiballismus 16739: 16737: 16734: 16730: 16727: 16726: 16725: 16722: 16718: 16715: 16714: 16713: 16710: 16706: 16703: 16701: 16698: 16696: 16693: 16692: 16691: 16688: 16687: 16686: 16683: 16682: 16680: 16678: 16673: 16669: 16666: 16664: 16660: 16657: 16655: 16650: 16646: 16636: 16633: 16631: 16628: 16624: 16621: 16620: 16619: 16616: 16615: 16613: 16611: 16606: 16598: 16595: 16594: 16593: 16592:Brain abscess 16590: 16588: 16585: 16581: 16578: 16576: 16573: 16571: 16568: 16566: 16563: 16562: 16561: 16558: 16557: 16555: 16553: 16549: 16546: 16544: 16540: 16536: 16532: 16524: 16519: 16517: 16512: 16510: 16505: 16504: 16501: 16495: 16492: 16490: 16487: 16476: 16472: 16468: 16466: 16462: 16457: 16453: 16452: 16447: 16442: 16441: 16431: 16427: 16426: 16422: 16420: 16416: 16415: 16411: 16409: 16405: 16404: 16400: 16399: 16396: 16392: 16385: 16381: 16380: 16376: 16374: 16370: 16369: 16365: 16363: 16359: 16355: 16354: 16350: 16346: 16344: 16340: 16336: 16332: 16331: 16327: 16323: 16321: 16317: 16313: 16309: 16305: 16304: 16300: 16296: 16295: 16292: 16287: 16283: 16260: 16256: 16250: 16234: 16230: 16224: 16209: 16208:Ronald Reagan 16205: 16199: 16191: 16187: 16181: 16166: 16162: 16155: 16139: 16133: 16118: 16114: 16108: 16092: 16088: 16082: 16066: 16062: 16061: 16055: 16047: 16031: 16027: 16023: 16016: 16008: 16004: 16000: 15994: 15986: 15982: 15974: 15970: 15963: 15955: 15951: 15945: 15934:September 17, 15930: 15929:The Economist 15926: 15920: 15912: 15908: 15904: 15900: 15896: 15892: 15888: 15884: 15880: 15876: 15869: 15853: 15849: 15845: 15841: 15837: 15833: 15832: 15827: 15820: 15805: 15801: 15795: 15776: 15769: 15763: 15755: 15751: 15747: 15743: 15739: 15735: 15731: 15727: 15720: 15712: 15708: 15704: 15700: 15695: 15690: 15685: 15680: 15676: 15672: 15668: 15661: 15653: 15649: 15645: 15641: 15637: 15636:NIHR Evidence 15633: 15627: 15619: 15615: 15610: 15605: 15601: 15597: 15593: 15589: 15585: 15578: 15563: 15559: 15553: 15538: 15534: 15533:"Healthfully" 15528: 15521: 15510:. MedicineNet 15509: 15502: 15495: 15483: 15477: 15462: 15458: 15452: 15437: 15433: 15427: 15419: 15415: 15411: 15407: 15403: 15399: 15392: 15376: 15372: 15368: 15364: 15358: 15350: 15346: 15341: 15336: 15332: 15328: 15324: 15320: 15316: 15309: 15307: 15305: 15303: 15301: 15299: 15297: 15295: 15287: 15283: 15277: 15275: 15273: 15264: 15262:93-80615-34-5 15258: 15254: 15247: 15239: 15235: 15231: 15229:0-387-50800-7 15225: 15221: 15220: 15212: 15204: 15200: 15196: 15192: 15188: 15184: 15180: 15176: 15169: 15161: 15157: 15153: 15149: 15145: 15141: 15137: 15133: 15126: 15118: 15114: 15109: 15104: 15099: 15094: 15090: 15086: 15082: 15075: 15067: 15063: 15059: 15055: 15051: 15047: 15043: 15039: 15032: 15030: 15021: 15017: 15012: 15007: 15003: 14999: 14995: 14991: 14987: 14980: 14965: 14961: 14955: 14940: 14936: 14930: 14922: 14918: 14914: 14910: 14906: 14902: 14898: 14891: 14883: 14877: 14873: 14869: 14862: 14860: 14851: 14847: 14842: 14837: 14832: 14827: 14823: 14819: 14815: 14808: 14800: 14796: 14792: 14788: 14784: 14780: 14776: 14772: 14765: 14757: 14753: 14748: 14743: 14739: 14735: 14732:(1): e12222. 14731: 14727: 14723: 14716: 14708: 14704: 14699: 14694: 14690: 14686: 14682: 14678: 14674: 14667: 14651: 14647: 14643: 14636: 14617: 14610: 14603: 14601: 14599: 14597: 14588: 14584: 14580: 14576: 14572: 14568: 14564: 14560: 14553: 14545: 14541: 14536: 14531: 14527: 14523: 14519: 14515: 14511: 14504: 14489: 14485: 14479: 14464: 14460: 14456: 14452: 14445: 14437: 14433: 14428: 14423: 14419: 14415: 14411: 14407: 14403: 14396: 14394: 14385: 14381: 14377: 14373: 14369: 14365: 14358: 14350: 14346: 14342: 14338: 14334: 14330: 14323: 14316: 14308: 14304: 14299: 14294: 14289: 14284: 14280: 14276: 14272: 14265: 14257: 14253: 14248: 14243: 14239: 14235: 14231: 14224: 14216: 14210: 14199: 14195: 14191: 14187: 14183: 14179: 14175: 14171: 14167: 14160: 14153: 14145: 14141: 14136: 14131: 14127: 14123: 14119: 14115: 14111: 14104: 14096: 14092: 14087: 14082: 14078: 14074: 14070: 14066: 14062: 14055: 14047: 14043: 14038: 14033: 14029: 14025: 14021: 14017: 14013: 14006: 13998: 13994: 13989: 13984: 13979: 13974: 13970: 13966: 13962: 13955: 13940: 13936: 13930: 13922: 13918: 13913: 13908: 13904: 13900: 13896: 13892: 13888: 13881: 13866: 13865:HelpGuide.org 13862: 13855: 13847: 13843: 13838: 13833: 13829: 13825: 13821: 13817: 13813: 13806: 13798: 13794: 13789: 13784: 13780: 13776: 13772: 13768: 13764: 13757: 13755: 13738: 13734: 13733: 13728: 13721: 13710: 13706: 13702: 13697: 13692: 13688: 13684: 13680: 13676: 13669: 13662: 13654: 13650: 13646: 13642: 13638: 13634: 13627: 13619: 13615: 13611: 13607: 13603: 13599: 13595: 13591: 13584: 13576: 13572: 13567: 13562: 13558: 13554: 13550: 13546: 13542: 13535: 13527: 13523: 13519: 13515: 13511: 13507: 13500: 13490: 13486: 13482: 13478: 13474: 13470: 13465: 13461: 13457: 13452: 13447: 13443: 13439: 13435: 13431: 13427: 13422: 13418: 13414: 13409: 13404: 13400: 13396: 13392: 13388: 13384: 13379: 13378: 13367: 13363: 13362: 13358: 13353: 13349: 13343: 13328: 13324: 13323: 13319: 13314: 13310: 13304: 13296: 13292: 13288: 13284: 13280: 13276: 13272: 13268: 13261: 13253: 13249: 13244: 13239: 13235: 13231: 13227: 13220: 13212: 13208: 13204: 13200: 13196: 13192: 13185: 13177: 13173: 13169: 13165: 13161: 13157: 13153: 13149: 13142: 13134: 13130: 13125: 13120: 13116: 13112: 13108: 13101: 13099: 13090: 13086: 13082: 13078: 13074: 13070: 13066: 13062: 13054: 13052: 13050: 13048: 13046: 13037: 13033: 13029: 13026:(in Danish). 13025: 13018: 13010: 13006: 13002: 12998: 12994: 12990: 12986: 12982: 12975: 12967: 12963: 12958: 12953: 12949: 12945: 12941: 12937: 12933: 12926: 12918: 12914: 12909: 12904: 12900: 12896: 12892: 12888: 12884: 12877: 12875: 12873: 12871: 12862: 12858: 12853: 12848: 12844: 12840: 12836: 12832: 12828: 12821: 12819: 12810: 12806: 12801: 12796: 12792: 12788: 12784: 12777: 12769: 12765: 12760: 12755: 12751: 12747: 12743: 12739: 12735: 12728: 12720: 12716: 12711: 12706: 12702: 12698: 12694: 12690: 12686: 12679: 12660: 12656: 12652: 12647: 12642: 12638: 12634: 12630: 12626: 12619: 12612: 12604: 12600: 12596: 12592: 12588: 12584: 12577: 12569: 12565: 12561: 12557: 12553: 12546: 12538: 12534: 12529: 12524: 12520: 12516: 12512: 12508: 12504: 12497: 12489: 12485: 12480: 12475: 12470: 12465: 12461: 12457: 12453: 12446: 12438: 12434: 12429: 12424: 12420: 12416: 12412: 12408: 12404: 12397: 12389: 12385: 12380: 12375: 12371: 12367: 12363: 12359: 12355: 12353: 12352:Ginkgo biloba 12344: 12336: 12332: 12327: 12322: 12318: 12314: 12310: 12306: 12302: 12295: 12293: 12291: 12289: 12280: 12276: 12271: 12266: 12262: 12258: 12254: 12250: 12246: 12239: 12231: 12227: 12222: 12217: 12213: 12209: 12205: 12198: 12190: 12186: 12181: 12176: 12172: 12168: 12164: 12160: 12153: 12146: 12138: 12134: 12130: 12126: 12122: 12115: 12099: 12095: 12089: 12074: 12070: 12066: 12065: 12061: 12056: 12052: 12046: 12030: 12026: 12022: 12018: 12012: 12010: 12008: 12006: 12004: 12002: 12000: 11991: 11987: 11982: 11977: 11973: 11969: 11965: 11961: 11957: 11950: 11942: 11938: 11933: 11928: 11923: 11918: 11914: 11910: 11906: 11899: 11891: 11887: 11882: 11877: 11873: 11869: 11865: 11861: 11857: 11850: 11835: 11831: 11830: 11826: 11821: 11817: 11811: 11803: 11799: 11795: 11791: 11787: 11783: 11776: 11768: 11764: 11759: 11754: 11750: 11746: 11742: 11735: 11727: 11723: 11718: 11713: 11709: 11705: 11701: 11697: 11693: 11686: 11678: 11672: 11664: 11660: 11656: 11652: 11648: 11644: 11640: 11636: 11628: 11620: 11616: 11611: 11606: 11602: 11598: 11595:(21): 1–470. 11594: 11590: 11586: 11579: 11577: 11568: 11564: 11560: 11556: 11552: 11548: 11541: 11539: 11530: 11526: 11521: 11516: 11511: 11506: 11502: 11498: 11494: 11487: 11479: 11475: 11470: 11465: 11461: 11457: 11453: 11449: 11445: 11438: 11430: 11426: 11421: 11416: 11412: 11408: 11404: 11400: 11396: 11389: 11381: 11377: 11372: 11367: 11363: 11359: 11355: 11351: 11347: 11340: 11332: 11328: 11324: 11320: 11316: 11312: 11309:(2): 85–100. 11308: 11304: 11300: 11293: 11291: 11282: 11278: 11274: 11270: 11266: 11262: 11258: 11254: 11247: 11245: 11233:September 19, 11229: 11228:The Economist 11225: 11219: 11211: 11207: 11202: 11197: 11192: 11187: 11183: 11179: 11175: 11168: 11166: 11164: 11155: 11151: 11146: 11141: 11137: 11133: 11129: 11125: 11121: 11114: 11106: 11102: 11097: 11092: 11088: 11084: 11080: 11076: 11072: 11068: 11064: 11057: 11049: 11045: 11040: 11035: 11031: 11027: 11023: 11016: 11014: 11005: 11001: 10997: 10993: 10990:(47): 42–45. 10989: 10985: 10978: 10970: 10966: 10962: 10958: 10951: 10943: 10939: 10935: 10929: 10925: 10918: 10910: 10906: 10901: 10896: 10892: 10888: 10884: 10880: 10876: 10869: 10867: 10858: 10854: 10850: 10846: 10842: 10838: 10834: 10830: 10823: 10815: 10811: 10807: 10803: 10799: 10792: 10784: 10780: 10776: 10772: 10768: 10764: 10760: 10756: 10751: 10746: 10742: 10735: 10727: 10723: 10718: 10713: 10709: 10705: 10701: 10697: 10693: 10686: 10678: 10674: 10670: 10666: 10661: 10656: 10652: 10648: 10644: 10637: 10629: 10625: 10621: 10617: 10613: 10612:NIHR Evidence 10609: 10603: 10595: 10591: 10587: 10583: 10579: 10575: 10571: 10567: 10560: 10552: 10548: 10543: 10538: 10534: 10530: 10526: 10522: 10518: 10511: 10503: 10499: 10495: 10491: 10487: 10483: 10475: 10467: 10463: 10458: 10453: 10449: 10445: 10441: 10437: 10433: 10426: 10418: 10414: 10409: 10404: 10400: 10396: 10392: 10385: 10377: 10373: 10368: 10363: 10359: 10355: 10351: 10347: 10343: 10336: 10328: 10324: 10319: 10314: 10310: 10306: 10302: 10298: 10294: 10287: 10285: 10283: 10281: 10272: 10268: 10264: 10260: 10256: 10252: 10248: 10244: 10236: 10228: 10224: 10220: 10216: 10212: 10208: 10204: 10200: 10192: 10184: 10180: 10175: 10170: 10166: 10162: 10158: 10154: 10150: 10143: 10135: 10131: 10127: 10123: 10118: 10113: 10109: 10105: 10101: 10097: 10093: 10086: 10078: 10074: 10069: 10064: 10060: 10056: 10052: 10048: 10044: 10037: 10029: 10025: 10020: 10015: 10011: 10007: 10003: 9999: 9995: 9988: 9980: 9976: 9971: 9966: 9961: 9956: 9952: 9948: 9947:Int J Mol Sci 9944: 9937: 9929: 9925: 9921: 9917: 9912: 9907: 9902: 9897: 9893: 9889: 9885: 9877: 9869: 9865: 9860: 9855: 9851: 9847: 9842: 9837: 9833: 9829: 9825: 9821: 9814: 9806: 9802: 9798: 9794: 9790: 9786: 9782: 9778: 9774: 9770: 9763: 9747: 9743: 9737: 9722: 9718: 9711: 9703: 9699: 9694: 9689: 9685: 9681: 9677: 9673: 9669: 9662: 9660: 9650: 9641: 9632: 9624: 9620: 9616: 9612: 9608: 9604: 9600: 9596: 9588: 9580: 9576: 9572: 9568: 9564: 9560: 9556: 9552: 9545: 9537: 9533: 9528: 9523: 9519: 9515: 9511: 9507: 9503: 9496: 9494: 9492: 9483: 9479: 9474: 9469: 9464: 9459: 9455: 9451: 9447: 9440: 9432: 9428: 9424: 9420: 9416: 9412: 9408: 9404: 9397: 9390: 9382: 9378: 9373: 9368: 9364: 9360: 9356: 9352: 9348: 9341: 9333: 9329: 9324: 9319: 9315: 9311: 9307: 9303: 9299: 9292: 9284: 9280: 9276: 9272: 9268: 9264: 9260: 9256: 9248: 9240: 9236: 9232: 9228: 9224: 9220: 9216: 9212: 9205: 9197: 9193: 9189: 9185: 9181: 9177: 9173: 9169: 9162: 9154: 9150: 9145: 9140: 9136: 9132: 9128: 9124: 9120: 9113: 9105: 9101: 9096: 9091: 9086: 9081: 9077: 9073: 9069: 9062: 9060: 9058: 9056: 9047: 9043: 9038: 9033: 9029: 9025: 9021: 9017: 9013: 9006: 8998: 8994: 8989: 8984: 8980: 8976: 8972: 8968: 8964: 8957: 8955: 8946: 8942: 8937: 8932: 8928: 8924: 8920: 8916: 8912: 8905: 8897: 8893: 8889: 8885: 8881: 8880:NIHR Evidence 8877: 8871: 8863: 8859: 8854: 8849: 8845: 8841: 8837: 8833: 8829: 8822: 8814: 8810: 8805: 8800: 8796: 8792: 8788: 8784: 8780: 8773: 8765: 8761: 8756: 8751: 8747: 8743: 8739: 8735: 8731: 8724: 8716: 8712: 8707: 8702: 8698: 8694: 8690: 8686: 8682: 8675: 8667: 8663: 8658: 8653: 8649: 8645: 8641: 8637: 8633: 8626: 8607: 8600: 8594: 8586: 8582: 8578: 8574: 8570: 8566: 8562: 8558: 8554: 8547: 8539: 8535: 8531: 8527: 8523: 8519: 8512: 8504: 8500: 8495: 8490: 8485: 8480: 8476: 8472: 8468: 8461: 8450: 8446: 8442: 8438: 8434: 8430: 8426: 8422: 8418: 8411: 8404: 8396: 8392: 8388: 8384: 8380: 8376: 8372: 8368: 8361: 8353: 8349: 8345: 8341: 8337: 8330: 8322: 8318: 8313: 8308: 8304: 8300: 8296: 8289: 8281: 8277: 8273: 8269: 8265: 8261: 8257: 8253: 8246: 8238: 8234: 8229: 8224: 8220: 8216: 8212: 8208: 8204: 8197: 8189: 8185: 8181: 8177: 8173: 8169: 8165: 8161: 8154: 8139: 8135: 8129: 8127: 8111: 8104: 8096: 8092: 8087: 8082: 8078: 8074: 8070: 8066: 8062: 8055: 8047: 8043: 8039: 8035: 8031: 8030:NIHR Evidence 8027: 8021: 8013: 8009: 8005: 8001: 7996: 7991: 7987: 7983: 7979: 7972: 7964: 7960: 7956: 7952: 7948: 7944: 7940: 7936: 7929: 7921: 7917: 7912: 7907: 7903: 7899: 7895: 7888: 7880: 7876: 7872: 7868: 7864: 7860: 7856: 7852: 7844: 7836: 7832: 7828: 7824: 7817: 7809: 7805: 7801: 7797: 7793: 7789: 7785: 7781: 7774: 7766: 7762: 7758: 7754: 7750: 7746: 7742: 7738: 7731: 7720: 7716: 7712: 7708: 7704: 7697: 7690: 7683: 7676: 7668: 7664: 7659: 7654: 7650: 7646: 7642: 7638: 7634: 7627: 7619: 7615: 7610: 7605: 7601: 7597: 7593: 7589: 7585: 7578: 7576: 7567: 7563: 7559: 7555: 7551: 7547: 7543: 7539: 7532: 7524: 7520: 7515: 7510: 7506: 7502: 7498: 7494: 7490: 7483: 7475: 7469: 7465: 7458: 7450: 7446: 7441: 7436: 7431: 7426: 7423:: 1051–1061. 7422: 7418: 7414: 7407: 7399: 7395: 7391: 7387: 7383: 7379: 7372: 7364: 7360: 7356: 7352: 7348: 7344: 7337: 7321: 7317: 7313: 7307: 7299: 7295: 7290: 7285: 7280: 7275: 7271: 7267: 7263: 7256: 7254: 7245: 7241: 7237: 7233: 7229: 7225: 7221: 7217: 7210: 7202: 7198: 7194: 7190: 7186: 7182: 7178: 7174: 7167: 7159: 7155: 7151: 7147: 7143: 7139: 7135: 7131: 7124: 7116: 7112: 7108: 7104: 7100: 7096: 7092: 7088: 7080: 7078: 7076: 7067: 7063: 7058: 7053: 7049: 7045: 7041: 7034: 7032: 7030: 7028: 7019: 7015: 7010: 7005: 7001: 6997: 6993: 6989: 6985: 6978: 6976: 6967: 6963: 6959: 6955: 6950: 6949:1959.13/24647 6945: 6941: 6937: 6933: 6929: 6922: 6907: 6903: 6897: 6889: 6885: 6880: 6875: 6871: 6865: 6861: 6857: 6853: 6846: 6844: 6842: 6833: 6829: 6824: 6819: 6814: 6809: 6805: 6801: 6797: 6790: 6782: 6778: 6773: 6768: 6764: 6760: 6756: 6752: 6748: 6741: 6733: 6729: 6725: 6721: 6718:treatments". 6713: 6705: 6701: 6695: 6693: 6676: 6672: 6666: 6658: 6654: 6649: 6644: 6640: 6636: 6632: 6628: 6624: 6617: 6609: 6605: 6600: 6595: 6591: 6587: 6583: 6579: 6575: 6568: 6553: 6552:ninds.nih.gov 6549: 6543: 6535: 6531: 6526: 6521: 6517: 6513: 6509: 6505: 6501: 6494: 6486: 6482: 6477: 6472: 6468: 6464: 6460: 6456: 6452: 6445: 6439: 6433: 6429: 6424: 6419: 6415: 6411: 6407: 6403: 6402:Lancet Neurol 6399: 6392: 6390: 6388: 6379: 6375: 6370: 6365: 6361: 6357: 6354:(1): 88–100. 6353: 6349: 6345: 6338: 6336: 6334: 6332: 6323: 6319: 6315: 6311: 6307: 6303: 6296: 6288: 6284: 6279: 6274: 6270: 6266: 6262: 6258: 6254: 6247: 6232: 6228: 6222: 6214: 6210: 6206: 6202: 6198: 6194: 6190: 6186: 6179: 6171: 6167: 6162: 6157: 6153: 6149: 6145: 6141: 6137: 6130: 6128: 6119: 6115: 6110: 6105: 6100: 6095: 6091: 6087: 6083: 6076: 6068: 6064: 6060: 6056: 6052: 6045: 6037: 6033: 6029: 6025: 6021: 6017: 6013: 6009: 6002: 5994: 5990: 5984: 5980: 5979: 5971: 5963: 5959: 5954: 5949: 5945: 5941: 5937: 5933: 5929: 5922: 5920: 5911: 5907: 5902: 5897: 5893: 5889: 5885: 5881: 5877: 5870: 5854: 5850: 5844: 5836: 5832: 5828: 5822: 5818: 5814: 5810: 5806: 5800: 5792: 5788: 5783: 5778: 5774: 5770: 5766: 5762: 5758: 5751: 5743: 5739: 5734: 5729: 5724: 5719: 5715: 5711: 5707: 5700: 5684: 5680: 5674: 5666: 5662: 5657: 5652: 5648: 5644: 5640: 5633: 5622: 5618: 5614: 5609: 5604: 5600: 5596: 5589: 5582: 5574: 5570: 5566: 5562: 5557: 5552: 5548: 5544: 5540: 5533: 5525: 5521: 5516: 5511: 5507: 5503: 5499: 5495: 5491: 5484: 5476: 5472: 5468: 5464: 5460: 5456: 5452: 5448: 5441: 5425: 5419: 5411: 5407: 5402: 5397: 5393: 5389: 5385: 5381: 5377: 5370: 5362: 5358: 5353: 5348: 5344: 5340: 5336: 5332: 5328: 5324: 5317: 5309: 5305: 5301: 5295: 5291: 5284: 5276: 5270: 5266: 5262: 5261: 5253: 5238: 5234: 5228: 5220: 5216: 5211: 5206: 5202: 5198: 5194: 5190: 5186: 5179: 5177: 5168: 5164: 5159: 5154: 5150: 5146: 5142: 5135: 5127: 5123: 5118: 5113: 5109: 5105: 5101: 5097: 5093: 5086: 5078: 5074: 5069: 5064: 5060: 5056: 5052: 5045: 5037: 5033: 5028: 5023: 5019: 5015: 5012:(1): e12016. 5011: 5007: 5003: 4995: 4993: 4984: 4980: 4976: 4972: 4968: 4964: 4960: 4956: 4948: 4946: 4937: 4933: 4929: 4925: 4921: 4917: 4913: 4909: 4902: 4894: 4890: 4885: 4880: 4876: 4872: 4868: 4864: 4860: 4853: 4845: 4841: 4836: 4831: 4826: 4821: 4817: 4813: 4809: 4802: 4787: 4783: 4776: 4760: 4756: 4750: 4735: 4729: 4721: 4717: 4712: 4707: 4703: 4699: 4695: 4691: 4687: 4680: 4678: 4669: 4665: 4660: 4655: 4650: 4645: 4641: 4637: 4636:PLOS Medicine 4633: 4626: 4618: 4614: 4610: 4606: 4602: 4601:NIHR Evidence 4598: 4592: 4585: 4572: 4568: 4567: 4562: 4555: 4540: 4536: 4532: 4525: 4518: 4502: 4498: 4492: 4477: 4473: 4467: 4459: 4453: 4445: 4441: 4437: 4433: 4426: 4411: 4407: 4401: 4386: 4382: 4376: 4368: 4364: 4359: 4354: 4350: 4346: 4342: 4338: 4334: 4327: 4325: 4316: 4312: 4307: 4302: 4298: 4294: 4290: 4286: 4282: 4275: 4267: 4263: 4259: 4255: 4251: 4245: 4241: 4237: 4233: 4226: 4218: 4214: 4209: 4204: 4200: 4196: 4192: 4188: 4184: 4177: 4169: 4165: 4160: 4155: 4151: 4147: 4143: 4136: 4134: 4118: 4117:ninds.nih.gov 4114: 4108: 4100: 4094: 4090: 4086: 4085: 4077: 4069: 4065: 4060: 4055: 4051: 4047: 4043: 4039: 4035: 4028: 4026: 4009: 4005: 4004: 3999: 3993: 3991: 3989: 3987: 3971: 3967: 3961: 3953: 3947: 3943: 3942: 3934: 3932: 3930: 3928: 3926: 3924: 3922: 3920: 3918: 3916: 3914: 3912: 3910: 3908: 3906: 3904: 3895: 3891: 3886: 3881: 3877: 3873: 3869: 3865: 3861: 3854: 3846: 3842: 3838: 3834: 3830: 3826: 3822: 3818: 3811: 3804: 3802: 3800: 3798: 3796: 3780: 3776: 3770: 3762: 3758: 3753: 3748: 3744: 3740: 3737:(1): 88–106. 3736: 3732: 3728: 3721: 3719: 3710: 3706: 3702: 3698: 3691: 3689: 3687: 3678: 3674: 3669: 3664: 3660: 3656: 3652: 3648: 3644: 3637: 3635: 3633: 3624: 3620: 3614: 3610: 3609: 3601: 3586: 3582: 3576: 3568: 3564: 3559: 3554: 3549: 3544: 3540: 3536: 3532: 3528: 3524: 3517: 3515: 3499:. Mayo Clinic 3498: 3494: 3488: 3477:September 26, 3473: 3469: 3463: 3461: 3459: 3457: 3455: 3453: 3451: 3449: 3447: 3445: 3443: 3441: 3439: 3437: 3421: 3417: 3411: 3407: 3390: 3383: 3379: 3374: 3370: 3360: 3357: 3356:Rita Hayworth 3354: 3350: 3348: 3344: 3342: 3338: 3336: 3333: 3329: 3327: 3323: 3321: 3320:Ronald Reagan 3317: 3315: 3311: 3309: 3305: 3303: 3299: 3298: 3297: 3294: 3292: 3288: 3285: 3284:ELLE Magazine 3281: 3277: 3273: 3272:Maria Shriver 3268: 3267: 3263: 3260: 3255: 3252: 3248: 3247: 3242: 3241:the Caretaker 3237: 3235: 3231: 3226: 3222: 3220: 3216: 3212: 3208: 3206: 3201: 3199: 3198:David Cameron 3193: 3189: 3183: 3178: 3169: 3167: 3166: 3161: 3157: 3156: 3150: 3148: 3142: 3139: 3135: 3131: 3127: 3123: 3122:schizophrenia 3119: 3115: 3114: 3108: 3106: 3102: 3098: 3088: 3086: 3082: 3077: 3072: 3070: 3069:Ronald Reagan 3066: 3062: 3056: 3052: 3049: 3044: 3041: 3036: 3034: 3030: 3026: 3022: 3018: 3014: 3010: 3005: 3001: 3000:Auguste Deter 2997: 2992: 2990: 2986: 2981: 2979: 2978: 2973: 2972: 2967: 2962: 2960: 2956: 2951: 2949: 2945: 2941: 2939: 2935: 2930: 2925: 2922: 2918: 2913: 2911: 2907: 2903: 2900: 2896: 2887: 2883: 2881: 2877: 2873: 2867: 2856: 2853: 2845: 2842:November 2015 2835: 2831: 2825: 2824: 2819:This section 2817: 2813: 2808: 2807: 2799: 2797: 2790: 2783:Affected ages 2780: 2776: 2774: 2768: 2764: 2762: 2758: 2754: 2750: 2736: >300 2730: 280–300 2724: 260–280 2718: 240–260 2712: 220–240 2706: 200–220 2701: 2698: 180–200 2692: 160–180 2686: 140–160 2680: 120–140 2674: 100–120 2668: <100 2663: 2662: 2657: 2653: 2634: 115–375 2611: 2579: 2578: 2572: 2563: 2561: 2556: 2547: 2545: 2541: 2539: 2535: 2530: 2520: 2518: 2514: 2510: 2500: 2497: 2487: 2468: 2458: 2454: 2450: 2448: 2444: 2440: 2437: 2433: 2423: 2420: 2416: 2411: 2406: 2402: 2392: 2388: 2386: 2382: 2378: 2374: 2370: 2366: 2362: 2358: 2354: 2343: 2341: 2337: 2332: 2329: 2325: 2318: 2313: 2311: 2307: 2303: 2299: 2294: 2291: 2286: 2282: 2281: 2280:Ginkgo biloba 2275: 2272: 2268: 2264: 2260: 2258: 2253: 2251: 2247: 2243: 2239: 2235: 2227: 2223: 2215: 2207: 2205: 2201: 2191: 2187: 2184: 2180: 2178: 2174: 2170: 2166: 2163: 2158: 2157:music therapy 2152: 2149: 2144: 2143:Adult daycare 2140: 2138: 2134: 2130: 2126: 2122: 2116: 2106: 2103: 2097: 2093: 2090: 2084: 2074: 2071: 2067: 2065: 2061: 2057: 2052: 2050: 2044: 2042: 2038: 2034: 2030: 2026: 2022: 2018: 2014: 2010: 2006: 2005:Mediterranean 2001: 1992: 1990: 1986: 1982: 1973: 1970: 1965: 1961: 1960: 1955: 1954: 1953:P. intermedia 1949: 1948: 1943: 1942: 1941:P. gingivalis 1937: 1936:oral bacteria 1933: 1926:Oral bacteria 1923: 1918:Dental health 1915: 1912: 1909: 1906: 1902: 1899: 1894: 1888: 1886: 1882: 1878: 1874: 1869: 1867: 1863: 1859: 1855: 1851: 1846: 1843: 1839: 1835: 1831: 1827: 1823: 1819: 1815: 1811: 1805: 1794: 1784: 1782: 1778: 1774: 1771:The value of 1769: 1766: 1762: 1758: 1753: 1751: 1747: 1743: 1733: 1731: 1727: 1726:liver enzymes 1723: 1719: 1715: 1711: 1707: 1703: 1699: 1695: 1688: 1678: 1674: 1672: 1671: 1666: 1664: 1657: 1655: 1651: 1647: 1643: 1639: 1635: 1631: 1627: 1623: 1619: 1615: 1611: 1607: 1598: 1595: 1592: 1590: 1587: 1586: 1583: 1580: 1577: 1575: 1572: 1571: 1568: 1565: 1562: 1560: 1557: 1556: 1552: 1550: 1547: 1545: 1542: 1539: 1538: 1531: 1527: 1517: 1515: 1511: 1507: 1503: 1499: 1494: 1492: 1491: 1485: 1483: 1479: 1475: 1471: 1461: 1459: 1455: 1451: 1447: 1443: 1439: 1437: 1433: 1429: 1425: 1421: 1417: 1413: 1409: 1405: 1401: 1396: 1394: 1393:neurosyphilis 1390: 1386: 1378: 1373: 1371: 1367: 1363: 1358: 1354: 1350: 1346: 1342: 1338: 1334: 1330: 1326: 1322: 1312: 1308: 1299: 1297: 1293: 1289: 1283: 1273: 1271: 1267: 1266:prion disease 1261: 1251: 1249: 1245: 1241: 1237: 1233: 1229: 1225: 1221: 1217: 1213: 1209: 1208:concentration 1205: 1201: 1200:HIV infection 1195: 1182: 1179: 1176: 1174:memory lapses 1173: 1170: 1169: 1168: 1165: 1163: 1159: 1155: 1149: 1139: 1137: 1133: 1129: 1125: 1120: 1118: 1113: 1111: 1107: 1103: 1096: 1086: 1084: 1080: 1076: 1067: 1065: 1061: 1057: 1052: 1048: 1042: 1032: 1030: 1026: 1022: 1018: 1014: 1010: 1006: 1002: 998: 996: 992: 986: 976: 974: 970: 965: 963: 959: 955: 951: 945: 943: 939: 935: 931: 926: 924: 920: 916: 912: 904: 899: 894: 884: 882: 878: 874: 870: 866: 861: 857: 847: 845: 841: 837: 833: 828: 826: 822: 811: 809: 798: 796: 792: 787: 785: 781: 776: 774: 764: 762: 758: 753: 749: 747: 743: 739: 735: 733: 729: 719: 717: 713: 709: 705: 701: 691: 689: 685: 675: 673: 662: 660: 656: 651: 649: 643: 641: 637: 633: 628: 624: 620: 616: 612: 608: 604: 600: 596: 595:psychological 592: 588: 584: 574: 572: 567: 563: 559: 554: 552: 548: 544: 540: 536: 532: 528: 523: 521: 517: 513: 509: 505: 501: 497: 493: 489: 485: 481: 477: 473: 468: 466: 462: 458: 454: 450: 446: 442: 438: 434: 430: 429:HIV infection 426: 422: 418: 414: 410: 406: 402: 398: 394: 390: 386: 384: 379: 375: 370: 368: 364: 360: 356: 352: 348: 344: 340: 337:. Aside from 336: 335:motor control 332: 328: 324: 320: 316: 312: 308: 299: 295: 291: 287: 283: 281: 277: 273: 271: 267: 263: 259: 255: 251: 247: 243: 240: 236: 233: 231: 227: 223: 219: 216: 214: 210: 206: 204: 200: 196: 192: 188: 184: 181: 177: 173: 169: 165: 161: 158: 154: 150: 148: 147:Complications 144: 140: 136: 132: 130: 126: 123: 119: 116: 114: 110: 106: 102: 98: 93: 89: 85: 80: 74: 70: 66: 61: 57: 40: 36: 32: 25: 20: 18984:Tuberculosis 18895:Malnutrition 18739:Health topic 18731:epidemiology 18559:Folie à deux 18484:Intoxication 18465:substances, 18463:Psychoactive 18382:Night terror 18199:Dissociative 18163:Panic attack 17934: 17715:Tic disorder 17402: 17301: 17274: 17235:Degenerative 16972:Inflammatory 16919: 16861: 16852:Stiff-person 16690:Parkinsonism 16663:Degenerative 16560:Encephalitis 16543:Inflammation 16533:, primarily 16478:. Retrieved 16474: 16449: 16423: 16412: 16401: 16377: 16366: 16347: 16324: 16297: 16262:. Retrieved 16258: 16249: 16237:. Retrieved 16232: 16223: 16211:. Retrieved 16207: 16198: 16189: 16180: 16168:. Retrieved 16164: 16154: 16142:. Retrieved 16132: 16120:. Retrieved 16116: 16107: 16095:. Retrieved 16090: 16081: 16069:. Retrieved 16058: 16046: 16034:. Retrieved 16015: 16002: 15993: 15984: 15972: 15968: 15962: 15944: 15932:. Retrieved 15928: 15919: 15878: 15874: 15868: 15856:. Retrieved 15831:The Guardian 15829: 15819: 15807:. Retrieved 15803: 15794: 15782:. Retrieved 15775:the original 15762: 15729: 15725: 15719: 15674: 15670: 15660: 15635: 15626: 15591: 15587: 15577: 15567:December 13, 15565:. Retrieved 15561: 15552: 15542:December 13, 15540:. Retrieved 15536: 15527: 15519: 15512:. Retrieved 15501: 15493: 15486:. Retrieved 15476: 15464:. Retrieved 15460: 15451: 15439:. Retrieved 15435: 15426: 15401: 15397: 15391: 15379:. Retrieved 15370: 15357: 15322: 15318: 15285: 15281: 15252: 15246: 15218: 15211: 15178: 15174: 15168: 15135: 15131: 15125: 15091:(15): 7899. 15088: 15084: 15074: 15041: 15037: 14993: 14989: 14979: 14967:. Retrieved 14963: 14954: 14942:. Retrieved 14938: 14929: 14907:(4): 56364. 14904: 14900: 14890: 14871: 14821: 14817: 14807: 14774: 14770: 14764: 14729: 14725: 14715: 14680: 14676: 14666: 14654:. Retrieved 14650:the original 14645: 14635: 14623:. Retrieved 14562: 14558: 14552: 14517: 14513: 14503: 14491:. Retrieved 14487: 14478: 14466:. Retrieved 14454: 14444: 14409: 14405: 14370:(7): 46–50. 14367: 14363: 14357: 14332: 14328: 14315: 14278: 14274: 14264: 14237: 14233: 14223: 14209:cite journal 14198:the original 14172:(1): 31–40. 14169: 14165: 14152: 14117: 14113: 14103: 14068: 14064: 14054: 14019: 14015: 14005: 13968: 13964: 13954: 13942:. Retrieved 13938: 13929: 13894: 13890: 13880: 13870:December 13, 13868:. Retrieved 13864: 13854: 13819: 13815: 13805: 13770: 13766: 13741:. Retrieved 13730: 13720: 13678: 13674: 13661: 13636: 13632: 13626: 13593: 13589: 13583: 13548: 13544: 13534: 13509: 13505: 13499: 13472: 13468: 13433: 13429: 13390: 13386: 13372:February 10, 13370:, retrieved 13355: 13342: 13333:February 10, 13331:, retrieved 13316: 13303: 13270: 13266: 13260: 13233: 13229: 13219: 13194: 13190: 13184: 13151: 13147: 13141: 13114: 13110: 13064: 13060: 13027: 13023: 13017: 12984: 12980: 12974: 12939: 12935: 12925: 12890: 12886: 12834: 12830: 12790: 12786: 12776: 12741: 12737: 12727: 12692: 12688: 12678: 12668:September 3, 12666:. Retrieved 12659:the original 12628: 12624: 12611: 12586: 12576: 12551: 12545: 12510: 12506: 12496: 12459: 12455: 12445: 12410: 12406: 12396: 12361: 12357: 12351: 12343: 12308: 12304: 12252: 12248: 12238: 12211: 12207: 12197: 12162: 12158: 12145: 12128: 12124: 12114: 12104:December 18, 12102:. Retrieved 12097: 12088: 12079:December 30, 12077:, retrieved 12058: 12045: 12033:. Retrieved 12024: 11963: 11959: 11949: 11912: 11908: 11898: 11863: 11859: 11849: 11838:, retrieved 11823: 11810: 11785: 11781: 11775: 11748: 11744: 11734: 11699: 11695: 11685: 11671:cite journal 11638: 11634: 11627: 11592: 11588: 11550: 11546: 11500: 11497:BMC Medicine 11496: 11486: 11451: 11447: 11437: 11402: 11398: 11388: 11353: 11349: 11339: 11306: 11302: 11256: 11252: 11231:. Retrieved 11227: 11218: 11181: 11177: 11127: 11123: 11113: 11070: 11066: 11056: 11029: 11025: 10987: 10983: 10977: 10960: 10956: 10950: 10923: 10917: 10882: 10878: 10832: 10828: 10822: 10797: 10791: 10740: 10734: 10699: 10695: 10685: 10650: 10646: 10636: 10611: 10602: 10569: 10565: 10559: 10524: 10520: 10510: 10485: 10481: 10474: 10439: 10435: 10425: 10398: 10394: 10384: 10349: 10345: 10335: 10300: 10296: 10246: 10242: 10235: 10202: 10198: 10191: 10156: 10152: 10142: 10099: 10095: 10085: 10050: 10046: 10036: 10001: 9997: 9987: 9953:(11): 2797. 9950: 9946: 9936: 9891: 9887: 9876: 9827: 9823: 9813: 9772: 9768: 9762: 9752:December 13, 9750:. Retrieved 9745: 9736: 9726:December 13, 9724:. Retrieved 9720: 9710: 9675: 9671: 9649: 9640: 9631: 9598: 9594: 9587: 9554: 9550: 9544: 9509: 9505: 9453: 9449: 9439: 9406: 9402: 9389: 9354: 9350: 9340: 9305: 9301: 9291: 9261:(1): 39–51. 9258: 9254: 9247: 9214: 9210: 9204: 9171: 9167: 9161: 9129:(2): 69–79. 9126: 9122: 9112: 9075: 9071: 9019: 9015: 9005: 8970: 8966: 8918: 8914: 8904: 8879: 8870: 8835: 8831: 8821: 8786: 8782: 8772: 8737: 8733: 8723: 8688: 8684: 8674: 8642:(1): 61–70. 8639: 8635: 8625: 8613:. Retrieved 8593: 8560: 8556: 8546: 8521: 8517: 8511: 8474: 8470: 8460: 8449:the original 8420: 8416: 8403: 8370: 8366: 8360: 8343: 8339: 8329: 8302: 8298: 8288: 8255: 8251: 8245: 8210: 8206: 8196: 8163: 8159: 8153: 8141:. Retrieved 8137: 8113:. Retrieved 8103: 8068: 8064: 8054: 8029: 8020: 7985: 7981: 7971: 7938: 7934: 7928: 7901: 7897: 7887: 7854: 7850: 7843: 7826: 7822: 7816: 7783: 7779: 7773: 7740: 7736: 7730: 7719:the original 7709:(7): 25–29. 7706: 7702: 7689: 7675: 7640: 7636: 7626: 7591: 7587: 7541: 7537: 7531: 7496: 7492: 7482: 7463: 7457: 7420: 7416: 7406: 7385: 7381: 7371: 7346: 7342: 7336: 7324:. Retrieved 7316:MDGuidelines 7315: 7306: 7269: 7265: 7219: 7215: 7209: 7176: 7172: 7166: 7133: 7129: 7123: 7093:(1): 21–27. 7090: 7086: 7047: 7043: 6991: 6987: 6931: 6927: 6921: 6911:December 13, 6909:. Retrieved 6905: 6896: 6851: 6803: 6799: 6789: 6754: 6750: 6740: 6723: 6719: 6712: 6703: 6679:. Retrieved 6674: 6665: 6630: 6626: 6616: 6581: 6577: 6567: 6555:. Retrieved 6551: 6542: 6507: 6503: 6493: 6458: 6454: 6444: 6405: 6401: 6351: 6347: 6308:(1): 87–95. 6305: 6301: 6295: 6260: 6256: 6246: 6234:. Retrieved 6230: 6221: 6188: 6185:Exp Gerontol 6184: 6178: 6143: 6139: 6089: 6085: 6075: 6058: 6054: 6044: 6011: 6007: 6001: 5977: 5970: 5935: 5931: 5883: 5879: 5869: 5857:. Retrieved 5852: 5843: 5808: 5799: 5764: 5760: 5750: 5713: 5709: 5699: 5687:. Retrieved 5682: 5673: 5646: 5642: 5632: 5598: 5594: 5581: 5546: 5542: 5532: 5497: 5493: 5483: 5450: 5446: 5440: 5428:. Retrieved 5418: 5383: 5379: 5369: 5334: 5330: 5316: 5289: 5283: 5259: 5252: 5240:. Retrieved 5236: 5227: 5192: 5188: 5148: 5144: 5134: 5099: 5095: 5085: 5058: 5054: 5044: 5009: 5005: 4958: 4954: 4911: 4907: 4901: 4866: 4862: 4852: 4818:(13): 6976. 4815: 4811: 4801: 4789:. Retrieved 4785: 4775: 4765:December 19, 4763:. Retrieved 4758: 4749: 4739:December 19, 4737:. Retrieved 4728: 4693: 4689: 4639: 4635: 4625: 4600: 4591: 4582: 4575:. Retrieved 4571:the original 4564: 4554: 4542:. Retrieved 4530: 4517: 4505:. Retrieved 4500: 4491: 4481:November 22, 4479:. Retrieved 4475: 4466: 4452: 4439: 4435: 4425: 4413:. Retrieved 4409: 4400: 4388:. Retrieved 4384: 4375: 4340: 4336: 4288: 4284: 4274: 4231: 4225: 4190: 4186: 4176: 4149: 4145: 4120:. Retrieved 4116: 4107: 4083: 4076: 4041: 4037: 4014:December 13, 4012:. Retrieved 4008:the original 4001: 3973:. Retrieved 3969: 3960: 3940: 3867: 3863: 3853: 3820: 3816: 3782:. Retrieved 3778: 3769: 3734: 3730: 3703:(128): 150. 3700: 3696: 3650: 3646: 3607: 3600: 3588:. Retrieved 3584: 3575: 3530: 3526: 3501:. Retrieved 3496: 3487: 3475:. Retrieved 3471: 3423:. Retrieved 3419: 3410: 3389: 3373: 3353:pin-up model 3341:Tony Bennett 3302:Bruce Willis 3295: 3269: 3265: 3264: 3256: 3244: 3238: 3227: 3223: 3213: 3209: 3202: 3194: 3190: 3186: 3163: 3159: 3153: 3151: 3146: 3143: 3137: 3125: 3121: 3117: 3111: 3109: 3100: 3096: 3094: 3073: 3065:World War II 3057: 3053: 3045: 3037: 2993: 2982: 2975: 2969: 2963: 2959:original sin 2952: 2942: 2926: 2914: 2892: 2871: 2869: 2848: 2839: 2828:Please help 2823:verification 2820: 2792: 2777: 2769: 2765: 2746: 2628: 46–114 2566:Epidemiology 2557: 2553: 2542: 2538:life support 2526: 2517:cannabinoids 2509:aromatherapy 2506: 2493: 2470: 2455: 2451: 2439:feeding tube 2429: 2415:psychosocial 2412: 2408: 2389: 2349: 2333: 2314: 2295: 2284: 2278: 2276: 2265: 2261: 2254: 2250:Rivastigmine 2232: 2221: 2213: 2197: 2188: 2181: 2171: 2167: 2153: 2141: 2118: 2098: 2094: 2086: 2068: 2053: 2045: 2002: 1998: 1979: 1976:Oral viruses 1959:T. forsythia 1957: 1951: 1947:F. nucleatum 1945: 1939: 1929: 1921: 1913: 1910: 1903: 1896:caused by a 1889: 1870: 1847: 1841: 1814:hearing loss 1807: 1798:Risk factors 1770: 1754: 1739: 1714:electrolytes 1684: 1675: 1668: 1661: 1658: 1650:FDA approval 1641: 1634:hearing loss 1628:. The MoCA ( 1620:(CASI), the 1603: 1588: 1573: 1558: 1495: 1488: 1486: 1474:brain biopsy 1467: 1440: 1397: 1389:Lyme disease 1374: 1318: 1309: 1305: 1285: 1263: 1238:, pallor of 1197: 1166: 1157: 1151: 1121: 1114: 1098: 1073: 1060:parkinsonism 1044: 999: 995:mini-strokes 988: 966: 958:inflammation 946: 927: 908: 853: 842:, a form of 829: 817: 804: 788: 777: 770: 754: 750: 736: 731: 727: 725: 716:chemosensory 697: 694:Pre-clinical 681: 678:Pre-dementia 668: 652: 648:credit score 644: 594: 590: 580: 555: 524: 504:Kufs disease 484:hypoglycemia 469: 433:HIV dementia 382: 371: 306: 305: 203:Risk factors 197:, and others 137:, decreased 73: 60: 38: 29:This is the 23: 18875:Hepatitis D 18870:Hepatitis C 18838:Chikungunya 18532:schizotypal 18367:Hypersomnia 18357:Nonorganic 18098:Agoraphobia 17829:Cyclothymia 17824:Bipolar NOS 17799:(affective) 17671:Stereotypic 17579:Kleptomania 17387:Fazio–Londe 17227:Both/either 17021:Generalised 16880:Early-onset 16875:Alzheimer's 16610:spinal cord 16444:‹ The 16403:MedlinePlus 16097:November 2, 15784:December 3, 15694:10454/17813 15537:Healthfully 15506:Taylor DC. 15461:Mayo Clinic 14969:January 10, 14777:(1): 1–14. 14625:October 30, 14488:www.who.int 14468:February 6, 14298:2066/137210 11087:1874/350441 10653:(6): 1–98. 9715:Goodman B. 8524:: 160–167. 7266:BMC Geriatr 6557:January 20, 6231:Mayo Clinic 5880:Drugs Aging 5242:January 12, 4415:December 9, 4390:February 7, 4122:December 9, 4003:Dementia UK 3975:January 20, 3970:icd.who.int 3590:January 20, 3425:January 20, 3351:Dancer and 3287:Nina Garcia 3134:paraphrenia 3091:Terminology 2955:Roger Bacon 2622: 25–45 2616: 18–24 2608: 14–17 2602: 11–13 2436:gastrostomy 2432:assist them 2218:Medications 2175:as part of 2062:, a strict 1964:spirochetes 1932:gum disease 1860:, and high 1850:neuroticism 1781:radiotracer 1779:(PiB) as a 1687:blood tests 1549:Specificity 1544:Sensitivity 1333:sarcoidosis 1228:macrophages 1035:Lewy bodies 1009:tobacco use 1001:Brain scans 973:the elderly 960:around the 930:hippocampus 825:incontinent 539:Blood tests 461:tauopathies 163:Usual onset 87:Other names 19045:Categories 19035:Psychology 19023:Psychiatry 18959:Snakebites 18855:Depression 18801:esophageal 18796:colorectal 18684:Stereotypy 18547:Delusional 18536:delusional 18509:Withdrawal 18377:Parasomnia 18282:Nosophobia 18062:Adjustment 18050:somatoform 17983:Sundowning 17836:Depression 17819:Bipolar II 17708:Stuttering 17703:Cluttering 17499:Paraphilia 16995:paroxysmal 16967:Autoimmune 16760:Dyskinesia 16630:Meningitis 16608:Brain and 16480:October 3, 16425:Patient UK 16379:DiseasesDB 15911:1919058612 15834:. London. 15508:"Dementia" 15466:October 1, 15441:October 4, 14493:August 12, 13743:August 31, 12581:Malouf R, 11962:(Review). 11911:(Review). 11862:(Review). 10767:2066/97731 9850:8147564576 9789:6947867710 8740:: 101269. 8615:January 1, 8471:J Pers Med 8143:January 1, 8115:January 1, 7378:"Delirium" 7132:(Review). 7089:(Review). 7046:(Review). 6990:(Review). 6930:(Review). 6457:(Review). 6404:(Review). 6350:(Review). 5882:(Review). 4507:October 3, 3866:(Review). 3823:: 100956. 3775:"Dementia" 3493:"Dementia" 3468:"Dementia" 3416:"Dementia" 3402:References 3314:Rosa Parks 3259:Tom Hunter 3061:penicillin 2902:Pythagoras 2864:See also: 2787:See also: 2596: 9–10 2399:See also: 2310:citalopram 2306:sertraline 2236:, such as 2077:Management 2033:flavonoids 1862:loneliness 1852:, and low 1830:inactivity 1826:depression 1802:See also: 1787:Prevention 1698:folic acid 1624:, and the 1553:Reference 1524:See also: 1424:porphyrias 1385:deficiency 1276:Alcoholism 1162:huntingtin 1007:, such as 969:anesthesia 742:tryptophan 738:Kynurenine 730:(MCI) and 718:networks. 591:behavioral 490:including 359:caregivers 351:motivation 270:Medication 245:Prevention 139:motivation 122:psychiatry 105:Lithograph 18944:Pneumonia 18932:childhood 18637:Catatonia 18569:Psychosis 18404:Postnatal 18387:Nightmare 17993:Wandering 17846:Dysthymia 17814:Bipolar I 17769:Pervasive 17584:Pyromania 17509:Voyeurism 17504:Fetishism 16992:Episodic/ 16870:Tauopathy 16821:Akathisia 16809:Myoclonus 16792:Athetosis 16724:Tauopathy 16414:eMedicine 16259:Peoplemag 16233:TODAY.com 16071:April 21, 15881:: j3445. 15858:April 27, 15840:0261-3077 15804:Brookdale 15711:216028843 15652:243269845 15514:August 6, 15488:August 6, 15044:: 15056. 14996:: 88–95. 14921:2155-7780 14799:253068389 14656:March 11, 14587:240122313 14463:0362-4331 13633:Nutrition 12809:2055-2335 12035:August 1, 11915:(1): 45. 11840:April 20, 11782:Maturitas 11663:206299435 11331:219081899 11323:1662-9647 11303:GeroPsych 11281:230618534 10783:205178315 10750:0706.4406 10677:225489651 10628:240719455 10594:235758241 10227:204699972 10134:243846602 9928:257499227 9894:(1): 81. 9824:Nutrients 9512:: 29143. 9211:Maturitas 8973:(9): 85. 8896:241649845 8477:(2): 20. 8188:145256616 8046:260465275 8012:256457783 7737:Neurology 7244:201118832 7173:Neurology 7050:(3): 10. 6504:Continuum 6348:Neurology 6257:Neurology 6036:233310698 5859:March 18, 5500:(3): 27. 5453:(9): 77. 5323:Rossor MN 5308:905089525 4617:251785991 4266:208230186 3864:Neurology 3845:201742825 3378:Prodromal 3345:Musician 3339:Musician 3312:Activist 3291:Tony Hawk 3266:Awareness 3085:PET scans 3013:pneumonia 3004:Frankfurt 2977:King Lear 2944:Byzantine 2917:Aristotle 2895:antiquity 2590: 5–8 2584: 0–4 2385:trazodone 2377:ramelteon 2373:melatonin 2365:hypnotics 2342:in 2022. 2321:vitamin B 2290:serotonin 2283:known as 2271:memantine 2238:donepezil 2229:Donepezil 2148:home care 2102:care home 2049:olive oil 2041:vitamin D 2037:vitamin B 2029:vitamin C 2025:vitamin E 2013:MIND diet 1691:vitamin B 1502:psychosis 1464:Diagnosis 1381:vitamin B 1244:dendritic 1230:into the 1224:monocytes 1206:and poor 722:Prodromal 684:prodromal 619:attention 599:agitation 566:donepezil 551:Screening 393:causative 369:process. 363:cognitive 355:continuum 289:Frequency 280:Prognosis 257:Treatment 118:Neurology 113:Specialty 19061:Dementia 19011:Medicine 18974:Syphilis 18885:HIV/AIDS 18843:Dementia 18816:prostate 18811:lymphoma 18791:cervical 18761:Bed bugs 18372:Insomnia 18042:Neurotic 18009:Delirium 17935:Dementia 17774:Specific 17358:SMALED2B 17353:SMALED2A 17050:Migraine 17042:Headache 17008:epilepsy 17004:Seizures 16862:Dementia 16765:Dystonia 16461:Dementia 16446:template 16430:Dementia 16264:July 19, 16239:July 19, 16213:July 19, 16170:July 19, 16144:July 19, 16122:July 19, 16091:BBC News 16065:Archived 16036:April 6, 16030:Archived 16007:Archived 15975:: 11–13. 15954:Archived 15907:ProQuest 15903:29011449 15895:28710087 15852:Archived 15848:60623878 15754:46762069 15746:29433981 15703:32306759 15618:19585957 15381:June 17, 15375:Archived 15363:Kolata G 15349:30906352 15238:19455117 15203:24808582 15117:34360196 15066:20844163 15058:27188934 15020:23878613 14944:June 28, 14850:33716715 14791:36404023 14756:35505899 14707:27733281 14616:Archived 14579:29425707 14559:Am J Med 14544:34998485 14436:33417236 14384:26463810 14349:18416791 14307:23828874 14256:24997202 14186:15945590 14144:34532852 14095:32813272 14046:17054228 13997:36812560 13944:June 28, 13921:28602027 13846:25874613 13797:30251253 13737:Archived 13709:Archived 13705:27533163 13618:43796062 13610:11842953 13575:19370678 13489:18519120 13460:20398123 13417:23002947 13366:archived 13327:archived 13295:21006144 13287:15673359 13252:16488350 13211:73245194 13176:27460864 13168:17015026 13133:17485039 13089:43777445 13081:17179836 13036:17032610 13009:88474685 13001:30925610 12966:22376048 12917:33189083 12861:36594432 12768:27527376 12719:27802359 12655:25004278 12646:11112650 12603:18843658 12568:21328305 12537:30168578 12488:27055878 12437:32925798 12407:Medicine 12388:30546253 12335:30648358 12279:18580597 12230:18316756 12189:23543555 12137:27903038 12073:archived 12029:Archived 11990:27042903 11941:26029267 11890:26595642 11834:archived 11802:34446273 11767:19433698 11726:16437532 11655:19538824 11619:22541366 11567:16409164 11529:19228370 11478:36930048 11469:10010156 11429:37389428 11420:10310315 11380:32101639 11273:33399054 11210:27044417 11154:25425445 11124:Dementia 11105:30033623 11048:29143695 11004:16913375 10969:21446290 10942:53373798 10909:32786083 10849:22336813 10814:12917907 10775:22071821 10726:29493789 10669:32721145 10586:34229505 10551:27538349 10502:25256214 10466:27489560 10417:23515663 10376:25874613 10327:34582034 10263:27245986 10219:31610547 10183:24605808 10126:34748207 10077:31496103 10028:27063583 9979:31181669 9920:36915130 9911:10012551 9868:26959055 9797:26553347 9746:Diabetes 9702:29957766 9615:21167244 9579:25898592 9571:29243693 9536:26385886 9482:25932012 9431:19633523 9423:29192686 9381:34615672 9351:BMJ Open 9332:32427305 9283:24193907 9275:29255847 9239:13998812 9231:29704910 9217:: 1–11. 9196:49383232 9188:29933487 9153:28894825 9104:31452865 9046:30767054 8997:27481112 8945:28658937 8862:32250480 8813:34275900 8764:33561581 8715:31302669 8666:31706889 8606:Archived 8585:33822160 8577:28960500 8538:35863541 8503:32225073 8445:12375536 8437:15545324 8395:39518497 8387:16785801 8321:10495584 8280:40462470 8272:19595951 8237:34275145 8180:15559753 8138:Medscape 8095:30828783 8004:36722180 7955:15817019 7920:15010086 7879:25322040 7808:43798118 7800:12614094 7757:17287448 7715:17163083 7667:31041124 7618:17178826 7566:20779164 7558:12779304 7523:34913981 7449:25031530 7398:Archived 7394:12643363 7363:20951272 7320:Archived 7298:26076729 7236:31433447 7201:25023606 7193:17101891 7158:24541533 7150:19733364 7107:29247390 7066:30806821 7018:19664365 6966:11864913 6958:16240488 6888:31733663 6832:23347747 6806:(1): 3. 6781:15965195 6732:11495003 6681:June 28, 6657:24366610 6608:27070344 6534:27042904 6485:27042903 6432:31519472 6378:28592453 6322:29569570 6287:32241955 6205:22796225 6170:24267647 6118:21344011 6067:12934968 6028:33874826 5993:Archived 5962:31638686 5910:30680679 5835:45950966 5805:Kosaka K 5791:29947927 5742:31229433 5689:July 30, 5665:31548122 5621:Archived 5617:14742586 5573:13753522 5565:29717753 5524:28283961 5467:27438597 5410:30630729 5361:17947337 5219:25037289 5167:30704681 5126:31632053 5077:28751584 5036:32995467 4983:53097138 4975:30370616 4936:46788701 4928:28416030 4893:33433688 4844:34209997 4791:June 28, 4720:23139705 4668:24015113 4577:July 27, 4544:July 27, 4444:Archived 4367:28360647 4315:25731881 4291:: h369. 4258:31753148 4217:35466396 4168:24145578 4068:30762136 3894:32241955 3837:31479764 3784:April 4, 3761:30497964 3709:22822592 3677:32738937 3623:Archived 3567:26760674 3330:TV Host 3182:Ethiopia 3138:dementia 3130:paranoia 3101:senility 3029:Tübingen 2876:syphilis 2872:Dementia 2461:Exercise 2369:delirium 2361:diazepam 2359:such as 2300:such as 2246:fainting 1834:diabetes 1746:MRI scan 1685:Routine 1665:(IQCODE) 1596:71–100% 1593:73–100% 1490:delirium 1448:such as 1319:Chronic 1248:neuronal 1216:lethargy 1051:delirium 1025:diabetes 979:Vascular 938:temporal 873:syphilis 640:diabetes 615:language 564:such as 516:epilepsy 514:such as 502:such as 492:thiamine 478:such as 431:causing 347:language 331:behavior 327:thinking 311:syndrome 307:Dementia 235:Delirium 171:Duration 135:language 129:Symptoms 82:Dementia 35:reviewed 18997:Portals 18964:Suicide 18927:Obesity 18900:Measles 18890:Leprosy 18831:ovarian 18826:stomach 18781:bladder 18729:Global 18081:Anxiety 17920:PDD-NOS 17809:Bipolar 17462: ( 17370:SMA-PME 17365:SMA-PCH 17348:SMALED1 17060:Tension 17055:Cluster 16780:Meige's 16597:Amoebic 16448:below ( 16373:D003704 15809:June 4, 15609:3181916 15418:1259639 15340:6428020 15195:9661992 15160:8262492 15152:3324141 15108:8345762 15011:3715758 14841:7952627 14747:9053375 14698:5388903 14535:8810394 14427:8094510 14194:7861568 14135:8446835 14086:7437395 14037:6823223 13988:9931370 13912:6481376 13837:9426996 13788:6513397 13696:4991625 13653:9263232 13566:7182132 13526:9040301 13451:2872797 13408:3470758 12957:3571677 12908:8094738 12852:9808594 12759:5129475 12710:6465000 12528:6513376 12428:7489658 12379:6267544 12326:6488894 12270:2718545 11981:5390937 11932:4448151 11881:5792067 11717:9006343 11610:4780923 11520:2649159 11371:7043362 11201:4820853 11145:5089222 11096:6513122 10900:8094398 10857:7086782 10717:6494367 10457:4959431 10408:3600589 10367:9426996 10318:8478014 10271:3464912 10174:3956752 10117:8574768 10068:6732706 10019:7117565 9970:6600544 9888:BMC Med 9859:4808873 9834:: 144. 9805:8188716 9693:6179018 9527:4575419 9473:4399390 9372:8496387 9323:7237983 9144:5527366 9095:6700845 9037:6399173 8988:4969323 8936:6909434 8853:7755119 8804:8887819 8755:8005464 8706:6628594 8657:7391421 8494:7354424 8352:9531917 8228:8406787 8108:Bee P. 8086:6398085 7963:9014589 7871:8054493 7835:3611032 7765:9129604 7658:6461420 7609:2117747 7514:8678688 7440:4099101 7326:June 4, 7289:4469007 7115:3943047 7009:2832614 6879:7372724 6823:3580328 6772:1739714 6648:3899480 6599:7292631 6525:5390934 6476:5390937 6423:7017451 6369:5496518 6278:7274845 6236:July 8, 6213:1153876 6161:3842016 6109:3034231 6092:: 272. 5953:7462122 5901:6435621 5782:6063327 5608:1738895 5515:5650061 5475:3331009 5430:May 10, 5401:6432780 5352:2373641 5265:591–603 5210:4104432 5117:6769202 5055:Science 5027:7507499 4884:7802608 4835:8297221 4711:3487532 4659:3754889 4501:cdc.gov 4385:apa.org 4358:5353163 4306:4707529 4208:9035877 4089:591–603 4059:6449308 3885:7274845 3779:who.int 3752:6291454 3668:7392084 3558:8812342 3503:June 5, 3472:who.int 3215:Driving 2802:History 2513:massage 2481:⁄ 2340:updated 2328:Statins 2285:EGb 761 1905:Frailty 1856:), low 1822:obesity 1818:smoking 1742:CT scan 1736:Imaging 1718:calcium 1704:(TSH), 1642:CognICA 1581:85–90% 1578:83–93% 1566:56–96% 1563:71–92% 1478:autopsy 1357:steroid 1288:alcohol 1236:gliosis 1234:(CNS), 1117:aphasia 950:amyloid 934:atrophy 923:insight 903:atrophy 734:(MBI). 547:obesity 535:imaging 506:, some 385:(DSM-5) 250:obesity 18969:Stroke 18880:Herpes 18786:breast 18776:Cancer 18756:Autism 18746:Asthma 18325:Eating 18173:Stress 18090:Phobia 18046:stress 17905:Autism 17698:Speech 17487:Sexual 17089:Stroke 16903:Pick's 16830:Tremor 16797:Chorea 16465:Curlie 16451:Curlie 16408:000739 15909:  15901:  15893:  15846:  15838:  15752:  15744:  15709:  15701:  15650:  15616:  15606:  15416:  15347:  15337:  15259:  15236:  15226:  15201:  15193:  15158:  15150:  15115:  15105:  15064:  15056:  15018:  15008:  14919:  14878:  14848:  14838:  14797:  14789:  14754:  14744:  14705:  14695:  14677:Lancet 14585:  14577:  14542:  14532:  14461:  14434:  14424:  14382:  14347:  14305:  14254:  14192:  14184:  14142:  14132:  14093:  14083:  14044:  14034:  13995:  13985:  13919:  13909:  13844:  13834:  13795:  13785:  13703:  13693:  13651:  13616:  13608:  13573:  13563:  13524:  13487:  13458:  13448:  13415:  13405:  13293:  13285:  13250:  13209:  13174:  13166:  13131:  13087:  13079:  13034:  13007:  12999:  12964:  12954:  12915:  12905:  12859:  12849:  12807:  12766:  12756:  12717:  12707:  12653:  12643:  12601:  12566:  12535:  12525:  12486:  12435:  12425:  12386:  12376:  12333:  12323:  12277:  12267:  12228:  12187:  12135:  11988:  11978:  11939:  11929:  11888:  11878:  11860:Lancet 11800:  11765:  11724:  11714:  11661:  11653:  11617:  11607:  11565:  11527:  11517:  11476:  11466:  11427:  11417:  11378:  11368:  11329:  11321:  11279:  11271:  11208:  11198:  11184:: 77. 11152:  11142:  11103:  11093:  11046:  11002:  10967:  10940:  10930:  10907:  10897:  10855:  10847:  10812:  10781:  10773:  10724:  10714:  10675:  10667:  10626:  10592:  10584:  10549:  10500:  10464:  10454:  10415:  10405:  10374:  10364:  10325:  10315:  10269:  10261:  10225:  10217:  10181:  10171:  10132:  10124:  10114:  10075:  10065:  10026:  10016:  9977:  9967:  9926:  9918:  9908:  9866:  9856:  9848:  9803:  9795:  9787:  9700:  9690:  9623:715832 9621:  9613:  9577:  9569:  9534:  9524:  9480:  9470:  9456:: 46. 9429:  9421:  9379:  9369:  9330:  9320:  9281:  9273:  9237:  9229:  9194:  9186:  9151:  9141:  9102:  9092:  9044:  9034:  8995:  8985:  8943:  8933:  8894:  8860:  8850:  8811:  8801:  8762:  8752:  8713:  8703:  8664:  8654:  8583:  8575:  8536:  8501:  8491:  8443:  8435:  8393:  8385:  8350:  8319:  8278:  8270:  8235:  8225:  8186:  8178:  8093:  8083:  8044:  8010:  8002:  7961:  7953:  7918:  7877:  7869:  7833:  7806:  7798:  7763:  7755:  7713:  7665:  7655:  7616:  7606:  7564:  7556:  7521:  7511:  7470:  7447:  7437:  7392:  7361:  7296:  7286:  7272:: 66. 7242:  7234:  7199:  7191:  7156:  7148:  7113:  7105:  7064:  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