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Apical and basolateral coated pits of MDCK cells differ in their rates of maturation into coated vesicles, but not in the ability to distinguish between hemagglutinin proteins with different internalization signals. J. Cell Biol. 129,
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and therapeutic molecules that paved the way towards translational research (live recombinant vaccines and cancer virotherapy). Later, he became the director of vaccine research at Berna
Biotech (now
147:
Characteristics of the internalization signal in the Y543 influenza virus hemagglutinin suggest a model for recognition of internalization signals containing tyrosine. J. Biol. Chem. 269, 3928-3933
122:. His research was instrumental towards understanding the intracellular mechanisms of viral and membrane protein sorting in epithelial cells and the cell-surface assembly of several
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Tyrosine-based
Membrane Protein Sorting Signals Are Differentially Interpreted by Polarized Madin-Darby Canine Kidney and LLC-PK1 Epithelial Cells. J. Biol. Chem. 273, 26862-26869
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Mutations in the Middle of the
Transmembrane Domain Reverse the Polarity of Transport of the Influenza Virus Hemagglutinin in MDCK Epithelial Cells. J. Cell Biol. 142, 51–57.
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Oncolytic measles virus in cutaneous T-cell lymphomas mount anti-tumor immune responses in vivo and target interferon resistant tumor cells. Blood, 106: 2287–2294.
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O-linked glycans mediate apical sorting of human intestinal sucrase-isomaltase through association with lipid rafts. Current
Biology 9, 593–596.
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at Dallas, his research focused on the (i) basis of enveloped viruses assembly, and (ii) the mechanisms of membrane protein sorting and
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Effects of altering palmitylation sites on the biosynthesis and function of the
Influenza virus Hemagglutinin. J. Virol. 66, 7585–7588.
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Measles virus matrix protein specifies apical virus release and glycoprotein sorting in epithelial cells. EMBO J. 19, 3576-3585
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Reverse genetics of measles virus and resulting multivalent recombinant vaccines. Curr. Topics
Microbiol. Immun. 329, 129–162.
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Measles virus spreads in rat hippocampal neurons by cell-to-cell contact and in a polarized fashion. J. Virol. 76, 5720–5728.
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Measles
Viruses with Altered Envelope Protein Cytoplasmic Tails Gain Cell Fusion Competence.J. Virol. 72, 1224–1234.
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Basis for selective incorporation of glycoproteins into influenza virus envelope. J. Virol. 67, 4831-4841
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82:, known for his research in cell biology (membrane protein sorting and internalization) and virology (
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98:). He has held several leading positions at prominent universities and biotechnology centers.
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Use of viral vectors for the development of vaccines. Exp. Rev. Vaccines, 6 (2): 255–266.
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Gene
Transfer into Neurons from Hippocampal Slices. Mol. Cell. Neurosci. 17, 855-871
126:. He was appointed as a faculty member at the institute of molecular biology of the
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Chimeric
Measles Viruses with a Foreign Envelope. J. Virol. 72, 2150–2159.
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Hussein Naim received his Ph.D. degree in biochemistry from the
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16:Lebanese-Swiss biochemist and molecular virologist
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112:University of Texas Southwestern Medical Center
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80:molecular virologist
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36:, Lebanon
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