113:. This can be important for the study of human liver diseases that are caused by an incorrect subcellular distribution of cell surface proteins, e.g., hepatocanalicular transport defects such as Dubin-Johnson Syndrome and progressive familial intrahepatic cholestasis (PFIC), and familial hypercholesterolemia. Hep G2 cells and their derivatives are also used as a model system for studies of liver metabolism and toxicity of
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model system for the study of polarized human hepatocytes. Another well-characterized polarized hepatocyte cell line is the rat hepatoma-derived hybrid cell line WIF-B. With the proper culture conditions, Hep G2 cells display robust morphological and functional differentiation with a
125:(and thus cytoprotective, anti-genotoxic, and cogenotoxic) agents, understanding hepatocarcinogenesis , and for drug targeting studies . Hep G2 cells are also employed in trials with bio-artificial liver devices .
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Mersch-Sundermann V, KnasmĂĽller S, Wu XJ, Darroudi F, Kassie F (May 2004). "Use of a human-derived liver cell line for the detection of cytoprotective, antigenotoxic and cogenotoxic agents".
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controllable formation of apical and basolateral cell surface domains (van IJzendoorn et al., 1997; 2000, etc.) that resemble the bile canalicular (BC) and sinusoidal domains, respectively,
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which was derived in 1975 from the liver tissue of a 15-year-old
Caucasian male from Argentina with a well-differentiated hepatocellular carcinoma. These cells are
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Aden DP, Fogel A, Plotkin S, Damjanov I, Knowles BB (December 1979). "Controlled synthesis of HBsAg in a differentiated human liver carcinoma-derived cell line".
258:"Poly(vinyl alcohol)/gelatin Hydrogels Cultured with HepG2 Cells as a 3D Model of Hepatocellular Carcinoma: A Morphological Study"
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virus surface antigens have not been detected. Hep G2 will respond to stimulation with human
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Ihrke G, Neufeld EB, Meads T, Shanks MR, Cassio D, Laurent M, et al. (December 1993).
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Moscato S, Ronca F, Campani D, Danti S (January 2015).
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309:"HepG2 (liver hepatocellular carcinoma): cell culture"
109:membrane proteins, and lipids in human hepatocytes
386:Hep G2 is a hepatoblastoma-derived cell line
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371:Sigma Aldrich Sales Page for Hep G2
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262:Journal of Functional Biomaterials
50:of 55, and are not tumorigenic in
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381:Cellosaurus entry for Hep G2
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89:Hep G2 cells are a suitable
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155:1979Natur.282..615A
68:alpha 1-antitrypsin
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72:transferrin
25:Hep G2
335:Toxicology
318:3 December
129:References
107:sinusoidal
60:fibrinogen
44:epithelial
123:genotoxic
119:cytotoxic
52:nude mice
33:cell line
395:Category
355:15138059
294:25590431
111:in vitro
103:in vitro
91:in vitro
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179:4359386
151:Bibcode
96:in vivo
56:albumin
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143:Nature
313:HepG2
175:S2CID
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