2865:
2850:
418:
1508:. The Inter-domain interactions also block all kringle ligand-binding sites apart from that of KR-1, suggesting that the latter domain governs pro-enzyme recruitment to targets. Analysis of an intermediate plasminogen structure suggests that plasminogen conformational change to the open form is initiated through KR-5 transiently peeling away from the PAp domain. These movements expose the KR5 lysine-binding site to potential binding partners, and suggest a requirement for spatially distinct lysine residues in eliciting plasminogen recruitment and conformational change respectively.
2880:
395:
2820:
3030:
3045:
2805:
2760:
2790:
2940:
317:
292:
2955:
3060:
3075:
2970:
2925:
2910:
2775:
669:
2985:
2835:
683:
676:
424:
323:
3015:
1445:(PLG) from the liver into the systemic circulation. Two major glycoforms of plasminogen are present in humans - type I plasminogen contains two glycosylation moieties (N-linked to N289 and O-linked to T346), whereas type II plasminogen contains only a single O-linked sugar (O-linked to T346). Type II plasminogen is preferentially recruited to the cell surface over the type I glycoform. Conversely, type I plasminogen appears more readily recruited to blood clots.
2895:
3000:
4847:
1522:
29:
1375:
1590:. The mechanism of plasmin inactivation involves the cleavage of an α2-macroglobulin at the bait region (a segment of the aM that is particularly susceptible to proteolytic cleavage) by plasmin. This initiates a conformational change such that the α2-macroglobulin collapses about the plasmin. In the resulting α2-macroglobulin-plasmin complex, the active site of plasmin is
1637:
within the kringle 3 domain of plasminogen, resulting in a novel type of dysplasminogenemia, represents the molecular basis of a subtype of hereditary angioedema with normal C1-inhibitor; the mutation creates a new lysine-binding site within kringle 3 and alters the glycosylation of plasminogen. The
1594:
shielded, thus substantially decreasing the plasmin's access to protein substrates. Two additional events occur as a consequence of bait region cleavage, namely (i) a h-cysteinyl-g-glutamyl thiol ester of the α2-macroglobulin becomes highly reactive and (ii) a major conformational change exposes a
1499:
The X-ray crystal structure of closed plasminogen reveals that the PAp and SP domains maintain the closed conformation through interactions made throughout the kringle array . Chloride ions further bridge the PAp / KR4 and SP / KR2 interfaces, explaining the physiological role of serum chloride in
2864:
2849:
55:
1503:
In closed plasminogen, access to the activation bond (R561/V562) targeted for cleavage by tPA and uPA is blocked through the position of the KR3/KR4 linker sequence and the O-linked sugar on T346. The position of KR3 may also hinder access to the
1500:
stabilizing the closed conformer. The structural studies also reveal that differences in glycosylation alter the position of KR3. These data help explain the functional differences between the type I and type II plasminogen glycoforms.
2879:
2819:
3029:
3044:
1448:
In circulation, plasminogen adopts a closed, activation-resistant conformation. Upon binding to clots, or to the cell surface, plasminogen adopts an open form that can be converted into active plasmin by a variety of
2873:: SOLUTION NMR STRUCTURE OF THE HUMAN PLASMINOGEN KRINGLE 1 DOMAIN COMPLEXED WITH 6-AMINOHEXANOIC ACID AT PH 5.3, 310K, DERIVED FROM RANDOMLY GENERATED STRUCTURES USING SIMULATED ANNEALING, MINIMIZED AVERAGE STRUCTURE
1496:. The Pan-Apple domain contains important determinants for maintaining plasminogen in the closed form, and the kringle domains are responsible for binding to lysine residues present in receptors and substrates.
2804:
431:
330:
2759:
2858:: SOLUTION NMR STRUCTURE OF THE HUMAN PLASMINOGEN KRINGLE 1 DOMAIN COMPLEXED WITH 6-AMINOHEXANOIC ACID AT PH 5.3, 310K, DERIVED FROM RANDOMLY GENERATED STRUCTURES USING SIMULATED ANNEALING, 12 STRUCTURES
2789:
1595:
conserved COOH-terminal receptor binding domain. The exposure of this receptor binding domain allows the α2-macroglobulin protease complex to bind to clearance receptors and be removed from circulation.
2939:
1473:(uPAR) is a cofactor for plasminogen activation by urokinase plasminogen activator. The conversion of plasminogen to plasmin involves the cleavage of the peptide bond between Arg-561 and Val-562.
2131:
Ploplis VA, Carmeliet P, Vazirzadeh S, Van
Vlaenderen I, Moons L, Plow EF, Collen D (November 1995). "Effects of disruption of the plasminogen gene on thrombosis, growth, and health in mice".
2954:
2468:
Campbell PG, Durham SK, Suwanichkul A, Hayes JD, Powell DR (August 1998). "Plasminogen binds the heparin-binding domain of insulin-like growth factor-binding protein-3".
3059:
3074:
3451:
2210:
Dewald G (March 2018). "A missense mutation in the plasminogen gene, within the plasminogen kringle 3 domain, in hereditary angioedema with normal C1 inhibitor".
2888:: STRUCTURE AND BINDING DETERMINANTS OF THE RECOMBINANT KRINGLE-2 DOMAIN OF HUMAN PLASMINOGEN TO AN INTERNAL PEPTIDE FROM A GROUP A STREPTOCOCCAL SURFACE PROTEIN
1638:
mutant plasminogen protein has been shown to be a highly efficient kininogenase that directly releases bradykinin from high- and low-molecular-weight kininogen.
1607:, as the clots are not adequately degraded. Plasminogen deficiency in mice leads to defective liver repair, defective wound healing, reproductive abnormalities.
2601:
Anglés-Cano E, Rojas G (January 2002). "Apolipoprotein(a): structure-function relationship at the lysine-binding site and plasminogen activator cleavage site".
2828:: THE STRUCTURE OF THE NON-COVALENT COMPLEX OF RECOMBINANT KRINGLE 1 DOMAIN OF HUMAN PLASMINOGEN WITH AMCHA (TRANS-4-AMINOMETHYLCYCLOHEXANE-1-CARBOXYLIC ACID)
4501:
2969:
3038:: The X-ray crystallographic structure of the angiogenesis inhibitor, angiostatin, bound a to a peptide from the group A streptococcal surface protein PAM
1051:
253:
4361:
3583:
1032:
2924:
2909:
4887:
1488:
Full length plasminogen comprises seven domains. In addition to a C-terminal chymotrypsin-like serine protease domain, plasminogen contains an
4101:
2088:
Romer J, Bugge TH, Pyke C, Lund LR, Flick MJ, Degen JL, Dano K (March 1996). "Impaired wound healing in mice with a disrupted plasminogen gene".
3053:: The X-ray crystallographic structure of the angiogenesis inhibitor, angiostatin, bound to a peptide from the group A streptococcus protein PAM
2774:
3617:
1746:
1728:
4009:
3115:
2984:
1986:
Wu G, Quek AJ, Caradoc-Davies TT, Ekkel SM, Mazzitelli B, Whisstock JC, Law RH (April 2019). "Structural studies of plasmin inhibition".
2704:
1259:
2813:: THE STRUCTURE OF THE NON-COVALENT COMPLEX OF RECOMBINANT KRINGLE 1 DOMAIN OF HUMAN PLASMINOGEN WITH EACA (EPSILON-AMINOCAPROIC ACID)
2682:
2834:
1266:
2768:: KRINGLE 2 DOMAIN OF HUMAN PLASMINOGEN: NMR SOLUTION STRUCTURE OF TRANS-4-AMINOMETHYLCYCLOHEXANE-1-CARBOXYLIC ACID (AMCHA) COMPLEX
4121:
1767:
2347:"Thrombospondin interaction with plasminogen. Evidence for binding to a specific region of the kringle structure of plasminogen"
2798:: STRUCTURE OF THE TERNARY MICROPLASMIN-STAPHYLOKINASE-MICROPLASMIN COMPLEX: A PROTEINASE-COFACTOR-SUBSTRATE COMPLEX IN ACTION.
3014:
2739:
2948:: X-RAY CRYSTAL STRUCTURE OF THE COMPLEX OF MICROPLASMINOGEN WITH ALPHA DOMAIN OF STREPTOKINASE IN THE PRESENCE CADMIUM IONS
1711:
4867:
3878:
52:
4094:
1690:
1615:
3610:
2894:
417:
4566:
4079:
4004:
3926:
3921:
1569:
4055:
2503:
Marcos-Contreras OA, Martinez de
Lizarrondo S, Bardou I, Orset C, Pruvost M, Anfray A, et al. (November 2016).
1551:
394:
3883:
3719:
3108:
1834:"Plasminogen Tochigi: inactive plasmin resulting from replacement of alanine-600 by threonine in the active site"
1715:
1694:
1667:
1647:
3709:
4087:
3659:
3562:
2505:"Hyperfibrinolysis increases blood-brain barrier permeability by a plasmin- and bradykinin-dependent mechanism"
1547:
1096:
4872:
4722:
3959:
3603:
2999:
2298:"Complex formation of platelet thrombospondin with plasminogen. Modulation of activation by tissue activator"
1611:
1077:
4877:
4321:
3911:
3764:
3293:
2247:"A mechanism for hereditary angioedema caused by a lysine 311-to-glutamic acid substitution in plasminogen"
1454:
316:
291:
233:
4837:
3101:
430:
329:
4823:
4810:
4797:
4784:
4771:
4758:
4745:
4707:
4236:
4221:
3999:
3557:
2732:
2963:: CRYSTAL AND MOLECULAR STRUCTURE OF HUMAN PLASMINOGEN KRINGLE 4 REFINED AT 1.9-ANGSTROMS RESOLUTION
1945:
Law RH, Caradoc-Davies T, Cowieson N, Horvath AJ, Quek AJ, Encarnacao JA, et al. (March 2012).
423:
322:
220:
4717:
4671:
4614:
4118:
3168:
2695:
2550:"Hepatic to pancreatic switch defines a role for hemostatic factors in cellular plasticity in mice"
1543:
1532:
1469:(Hageman factor). Fibrin is a cofactor for plasminogen activation by tissue plasminogen activator.
1326:
1221:
1166:
241:
4619:
4511:
4476:
4471:
3228:
3178:
3164:
2029:
Bezerra JA, Bugge TH, Melin-Aldana H, Sabla G, Kombrinck KW, Witte DP, Degen JL (December 1999).
1627:
1536:
1591:
1242:
1217:
1191:
1170:
3825:
3821:
3789:
2245:
Dickeson SK, Kumar S, Sun MF, Mohammed BM, Phillips DR, Whisstock JC, et al. (May 2022).
4640:
4559:
4466:
4316:
3940:
3684:
3653:
3643:
3254:
3068:: THE REFINED STRUCTURE OF THE EPSILON-AMINOCAPROIC ACID COMPLEX OF HUMAN PLASMINOGEN KRINGLE
2638:
Ranson M, Andronicos NM (May 2003). "Plasminogen binding and cancer: promises and pitfalls".
1583:
1423:
3083:: STRUCTURE AND LIGAND DETERMINANTS OF THE RECOMBINANT KRINGLE 5 DOMAIN OF HUMAN PLASMINOGEN
4712:
4456:
3511:
3327:
2725:
2679:
2561:
2042:
1845:
305:
3981:
1893:"Molecular cloning and characterization of a full-length cDNA clone for human plasminogen"
8:
4676:
4356:
4346:
4163:
4158:
3991:
3968:
3949:
3931:
3626:
3506:
3446:
3192:
3182:
3172:
1655:
1587:
261:
2565:
2046:
1849:
4882:
4609:
3634:
3532:
3424:
2626:
2584:
2549:
2273:
2246:
2113:
2031:"Plasminogen deficiency leads to impaired remodeling after a toxic injury to the liver"
2011:
1922:
1809:
1782:
1470:
265:
4109:
2445:
2428:
2404:
2387:
2322:
2297:
1868:
1833:
966:
961:
956:
951:
946:
941:
936:
931:
926:
921:
916:
911:
906:
901:
896:
891:
886:
881:
876:
871:
855:
850:
845:
840:
835:
830:
825:
820:
815:
810:
805:
789:
784:
779:
774:
769:
764:
759:
754:
749:
744:
739:
734:
729:
724:
4338:
4019:
3976:
3541:
3441:
3384:
2655:
2618:
2589:
2526:
2485:
2450:
2409:
2368:
2327:
2278:
2227:
2189:
2184:
2167:
2148:
2105:
2070:
2065:
2030:
2003:
1968:
1914:
1909:
1892:
1873:
1814:
1634:
1403:
1399:
1378:
Fibrinolysis (simplified). Blue arrows denote stimulation, and red arrows inhibition.
213:
45:
2630:
2481:
2117:
2015:
4655:
4650:
4624:
4552:
4130:
4032:
4027:
3124:
2691:
2647:
2610:
2579:
2569:
2516:
2477:
2440:
2399:
2358:
2317:
2309:
2268:
2258:
2219:
2179:
2140:
2097:
2060:
2050:
1995:
1958:
1926:
1904:
1863:
1853:
1804:
1794:
1651:
510:
441:
385:
340:
2345:
DePoli P, Bacon-Baguley T, Kendra-Franczak S, Cederholm MT, Walz DA (March 1989).
245:
4702:
4686:
4599:
4371:
4366:
4138:
4114:
3699:
3678:
3664:
3283:
3204:
2686:
2521:
2504:
2502:
1963:
1946:
1505:
1431:
1383:
485:
269:
2978:: THE STRUCTURE OF RECOMBINANT PLASMINOGEN KRINGLE 1 AND THE FIBRIN BINDING SITE
2388:"On the mechanism of the reaction between human alpha 2-antiplasmin and plasmin"
2363:
2346:
1751:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1733:
National Center for
Biotechnology Information, U.S. National Library of Medicine
4851:
4740:
4681:
4037:
3399:
3356:
3273:
3144:
2554:
Proceedings of the
National Academy of Sciences of the United States of America
2223:
2035:
Proceedings of the
National Academy of Sciences of the United States of America
1838:
Proceedings of the
National Academy of Sciences of the United States of America
1493:
1419:
586:
4861:
4645:
4604:
4516:
4389:
4378:
4110:
3850:
3774:
3729:
3516:
3498:
3436:
3394:
3390:
3222:
2708:
2263:
2144:
2055:
1799:
711:
2574:
1858:
668:
646:
524:
4594:
4412:
4306:
4148:
4047:
3893:
3858:
3188:
3132:
2659:
2622:
2593:
2530:
2344:
2282:
2231:
2193:
2074:
2007:
1972:
1818:
1348:
1337:
503:
282:
2933:: CRYSTAL STRUCTURE OF MICROPLASMINOGEN-STREPTOKINASE ALPHA DOMAIN COMPLEX
2489:
2454:
2372:
2331:
2152:
2109:
1918:
1877:
1306:
1301:
682:
675:
4818:
4753:
4589:
4531:
4526:
4175:
3901:
3836:
3807:
3754:
3547:
3537:
3429:
3380:
3317:
3298:
3258:
3247:
3215:
2413:
1477:
1415:
1395:
1391:
1141:
1122:
2918:: STRUCTURE OF KRINGLE 4 AT 4C TEMPERATURE AND 1.67 ANGSTROMS RESOLUTION
2614:
2130:
1999:
1329:
4493:
4435:
4216:
4211:
4191:
3817:
3779:
3739:
3734:
3724:
3478:
2101:
1663:
1604:
1489:
1466:
1462:
402:
299:
249:
3595:
2548:
Shanmukhappa K, Mourya R, Sabla GE, Degen JL, Bezerra JA (July 2005).
2313:
190:
186:
182:
178:
174:
170:
166:
162:
158:
154:
150:
146:
142:
138:
134:
130:
126:
122:
118:
114:
110:
106:
102:
98:
94:
90:
86:
82:
78:
74:
4792:
4766:
4521:
4507:
4326:
4206:
4196:
3916:
3873:
3868:
3863:
3749:
3744:
3483:
3470:
3342:
3322:
1891:
Forsgren M, Råden B, Israelsson M, Larsson K, Hedén LO (March 1987).
1458:
1407:
996:
469:
456:
368:
355:
257:
3093:
2783:: COMPLEX OF THE CATALYTIC DOMAIN OF HUMAN PLASMIN AND STREPTOKINASE
1521:
4846:
4407:
4402:
4351:
4201:
4186:
4153:
3812:
3802:
3797:
3364:
3332:
3135:
1410:. Plasmin is also integrally involved in inflammation. It cleaves
1344:
1290:
28:
4461:
4451:
4397:
4143:
4064:
3461:
3404:
2651:
2296:
Silverstein RL, Leung LL, Harpel PC, Nachman RL (November 1984).
1450:
1438:
1427:
1352:
1108:
1063:
981:
977:
1944:
1619:
237:
4805:
4575:
4488:
4430:
3831:
3688:
3488:
3154:
2675:
1659:
1411:
1387:
1374:
1341:
1322:
1274:
1018:
691:
2717:
2467:
1947:"The X-ray crystal structure of full-length human plasminogen"
1890:
932:
positive regulation of blood vessel endothelial cell migration
887:
negative regulation of cell-cell adhesion mediated by cadherin
4779:
4497:
4483:
4422:
4296:
4291:
4286:
4281:
4276:
4271:
3879:
Protein Z-related protease inhibitor (ZPI) (inhibits FX, FXI)
3673:
3668:
3552:
2993:: KRINGLE-KRINGLE INTERACTIONS IN MULTIMER KRINGLE STRUCTURES
2295:
2028:
1333:
2547:
16:
Enzyme in human blood that degrades clots and other proteins
4266:
4261:
4256:
4251:
4246:
4241:
4231:
4226:
3693:
1363:
4544:
952:
proteolysis involved in cellular protein catabolic process
2843:: CRYSTAL STRUCTURE OF HUMAN PLASMINOGEN CATALYTIC DOMAIN
1985:
2244:
493:
1831:
821:
extrinsic component of external side of plasma membrane
3884:
Tissue factor pathway inhibitor (TFPI) (inhibits FIII)
1832:
Miyata T, Iwanaga S, Sakata Y, Aoki N (October 1982).
1483:
4835:
2678:
online database for peptidases and their inhibitors:
1783:"Using antifibrinolytics to tackle neuroinflammation"
658:
1511:
912:
negative regulation of cell population proliferation
2212:
3950:Thrombin-activatable fibrinolysis inhibitor (TAFI)
3023:: Human PLASMINOGEN CATALYTIC DOMAIN, K698M MUTANT
2087:
1707:
1705:
1703:
1686:
1684:
1682:
4010:Activated protein C–protein C inhibitor (APC–PCI)
2165:
440:
339:
4859:
2637:
2600:
2429:"The reactive site of human alpha 2-antiplasmin"
1394:proteins in various other systems: It activates
3859:Antithrombin (inhibits FII, FIX, FX, FXI, FXII)
1700:
1679:
1712:GRCm38: Ensembl release 89: ENSMUSG00000059481
1662:. Moreover, plasmin induces the generation of
1390:blood clots. Apart from fibrinolysis, plasmin
877:negative regulation of cell-substrate adhesion
4560:
4095:
3611:
3109:
2733:
2166:Schuster V, HĂĽgle B, Tefs K (December 2007).
2461:
2426:
2420:
2385:
2338:
2289:
1691:GRCh38: Ensembl release 89: ENSG00000122194
1582:Plasmin is inactivated by proteins such as
1550:. Unsourced material may be challenged and
962:labyrinthine layer blood vessel development
4567:
4553:
4102:
4088:
3618:
3604:
3116:
3102:
2903:: The X-ray Structure of Human Angiostatin
2740:
2726:
2705:United States National Library of Medicine
2379:
1940:
1938:
1936:
1825:
1780:
1351:. In humans, the plasmin protein (in the
3927:Plasminogen activator inhibitor-2 (PAI-2)
3922:Plasminogen activator inhibitor-1 (PAI-1)
3584:disorders of globin and globulin proteins
2694:at the U.S. National Library of Medicine
2583:
2573:
2520:
2444:
2403:
2362:
2321:
2272:
2262:
2205:
2203:
2183:
2064:
2054:
1962:
1908:
1867:
1857:
1808:
1798:
1570:Learn how and when to remove this message
613:fetal liver hematopoietic progenitor cell
2703:This article incorporates text from the
1762:
1760:
1471:Urokinase plasminogen activator receptor
1373:
856:collagen-containing extracellular matrix
851:intracellular membrane-bounded organelle
4888:Extracellular matrix remodeling enzymes
3625:
1933:
4860:
4115:serine proteases/serine endopeptidases
3720:High-molecular-weight kininogen (HMWK)
2209:
2200:
1347:. The degradation of fibrin is termed
957:trophoblast giant cell differentiation
846:extrinsic component of plasma membrane
4548:
4083:
3599:
3123:
3097:
2721:
2302:The Journal of Clinical Investigation
2172:Journal of Thrombosis and Haemostasis
1757:
445:
406:
401:
344:
303:
298:
2386:Wiman B, Collen D (September 1979).
1548:adding citations to reliable sources
1515:
4005:Thrombin–antithrombin complex (TAT)
2433:The Journal of Biological Chemistry
2392:The Journal of Biological Chemistry
1884:
1616:Online Mendelian Inheritance in Man
1484:Mechanism of plasminogen activation
902:positive regulation of fibrinolysis
882:negative regulation of fibrinolysis
13:
3912:Tissue plasminogen activator (tPA)
3869:Protein S (cofactor for protein C)
2540:
2470:The American Journal of Physiology
1781:Atsev S, Tomov N (December 2020).
1610:In humans, a rare disorder called
760:serine-type endopeptidase activity
14:
4899:
3008:: CATALYTIC DOMAIN OF PLASMINOGEN
2668:
1512:Mechanism of plasmin inactivation
1490:N-terminal Pan Apple domain (PAp)
4845:
3073:
3058:
3043:
3028:
3013:
2998:
2983:
2968:
2953:
2938:
2923:
2908:
2893:
2878:
2863:
2848:
2833:
2818:
2803:
2788:
2773:
2758:
2185:10.1111/j.1538-7836.2007.02776.x
1988:Biochemical Society Transactions
1626:gene and is often manifested by
1622:) is caused by mutations of the
1520:
947:muscle cell cellular homeostasis
897:extracellular matrix disassembly
681:
674:
667:
429:
422:
416:
393:
328:
321:
315:
290:
27:
4000:Prothrombin fragment 1+2 (F1+2)
3660:Platelet membrane glycoproteins
2747:
2496:
2482:10.1152/ajpendo.1998.275.2.E321
2427:Shieh BH, Travis J (May 1987).
2238:
2159:
2124:
2081:
2022:
1979:
1668:high-molecular-weight kininogen
1641:
1603:Plasmin deficiency may lead to
770:proteasome core complex binding
730:protein domain specific binding
3864:Protein C (inhibits FV, FVIII)
3563:Extracellular matrix protein 1
1774:
1739:
1721:
1402:, and weakens the wall of the
745:serine-type peptidase activity
692:More reference expression data
647:More reference expression data
1:
4327:Urinary plasminogen activator
2446:10.1016/S0021-9258(18)45536-6
2405:10.1016/S0021-9258(19)86843-6
1673:
1612:plasminogen deficiency type I
1461:plasminogen activator (uPA),
414:
313:
4322:Tissue plasminogen activator
3294:Sex hormone-binding globulin
2522:10.1182/blood-2016-03-705384
1964:10.1016/j.celrep.2012.02.012
1910:10.1016/0014-5793(87)81501-6
1787:Neural Regeneration Research
1598:
1455:tissue plasminogen activator
831:platelet alpha granule lumen
224:, plasminogen, plasmin, HAE4
7:
4868:Genes on human chromosome 6
4574:
3740:Factor XII (Hageman factor)
3654:von Willebrand factor (vWF)
2364:10.1182/blood.V73.4.976.976
1666:in mice and humans through
1430:, belongs to the family of
1369:
10:
4904:
4060:-antiplasmin complex (PAP)
3775:Factor III (tissue factor)
2224:10.1016/j.bbrc.2017.12.060
1768:"Entrez Gene: plasminogen"
1646:Plasmin has been shown to
1476:Plasmin cleavage produces
967:mononuclear cell migration
750:signaling receptor binding
617:sexually immature organism
4731:
4723:Michaelis–Menten kinetics
4695:
4664:
4633:
4582:
4444:
4421:
4413:Proteinase 3/Myeloblastin
4387:
4337:
4174:
4129:
4046:
4018:
3990:
3967:
3958:
3892:
3849:
3788:
3763:
3708:
3642:
3633:
3575:
3558:Vitamin D-binding protein
3525:
3497:
3469:
3460:
3417:
3373:
3355:
3308:
3281:
3272:
3237:
3202:
3152:
3143:
3131:
2753:
1747:"Mouse PubMed Reference:"
1729:"Human PubMed Reference:"
1437:Plasmin is released as a
1305:
1300:
1296:
1289:
1273:
1254:
1239:
1235:
1214:
1210:
1203:
1188:
1184:
1163:
1159:
1152:
1139:
1135:
1120:
1116:
1107:
1094:
1090:
1075:
1071:
1062:
1049:
1045:
1030:
1026:
1017:
1002:
995:
991:
975:
710:
706:
689:
666:
657:
644:
593:
584:
551:Descending thoracic aorta
531:
522:
492:
484:
480:
463:
450:
413:
392:
383:
379:
362:
349:
312:
289:
280:
276:
231:
228:
218:
211:
206:
71:
66:
49:
44:
39:
35:
26:
21:
4615:Diffusion-limited enzyme
3982:β-Thromboglobulin (β-TG)
3169:Alpha 1-antichymotrypsin
2696:Medical Subject Headings
2264:10.1182/blood.2021012945
2168:"Plasminogen deficiency"
2145:10.1161/01.cir.92.9.2585
2056:10.1073/pnas.96.26.15143
1800:10.4103/1673-5374.284979
1398:, some mediators of the
1260:Chr 6: 160.7 – 160.75 Mb
942:myoblast differentiation
3977:Platelet factor 4 (PF4)
3874:Protein Z (inhibits FX)
3808:Prothrombin (factor II)
3452:7S seed storage protein
3229:Retinol binding protein
2640:Frontiers in Bioscience
2575:10.1073/pnas.0501691102
1859:10.1073/pnas.79.20.6132
1628:ligneous conjunctivitis
1494:Kringle domains (KR1-5)
1267:Chr 17: 12.6 – 12.64 Mb
775:protein antigen binding
4467:Proprotein convertases
4033:Fibrinopeptide B (FpB)
4028:Fibrinopeptide A (FpA)
3700:Glycoprotein VI (GPVI)
3665:Glycoprotein Ib (GPIb)
1386:that acts to dissolve
1379:
892:platelet degranulation
780:endopeptidase activity
725:apolipoprotein binding
543:metanephric glomerulus
4708:Eadie–Hofstee diagram
4641:Allosteric regulation
4317:Plasminogen activator
3851:Anticoagulant factors
3818:Fibrinogen (factor I)
3813:Thrombin (factor IIa)
3685:Glycoprotein IIb/IIIa
3679:Glycoprotein IX (GP9)
3646:(platelet activation)
3255:alpha-2-Macroglobulin
1424:von Willebrand factor
1377:
826:extracellular exosome
567:right coronary artery
408:Chromosome 17 (mouse)
4873:Acute-phase proteins
4718:Lineweaver–Burk plot
4457:Prolyl endopeptidase
4038:Fibrin monomers (FM)
3894:Fibrinolytic factors
3712:(contact activation)
3512:Bovine serum albumin
3328:Beta-2 microglobulin
2603:Biological Chemistry
1544:improve this section
1359:) is encoded by the
1340:proteins, including
811:extracellular region
447:17 A1|17 8.5 cM
306:Chromosome 6 (human)
67:List of PDB id codes
40:Available structures
4878:Fibrinolytic system
3992:Thrombin generation
3969:Platelet activation
3960:Coagulation markers
3635:Coagulation factors
3627:Coagulation cascade
3507:Human serum albumin
3447:11S globulin family
3193:Heparin cofactor II
3183:Alpha 2-antiplasmin
3173:Alpha 1-antitrypsin
2615:10.1515/BC.2002.009
2566:2005PNAS..10210182S
2560:(29): 10182–10187.
2047:1999PNAS...9615143B
2041:(26): 15143–15148.
2000:10.1042/bst20180211
1850:1982PNAS...79.6132M
1656:Alpha 2-antiplasmin
1492:together with five
1336:that degrades many
937:tissue regeneration
836:extracellular space
806:blood microparticle
535:right lobe of liver
4677:Enzyme superfamily
4610:Enzyme promiscuity
3832:Fibrin (factor Ia)
3644:Primary hemostasis
3533:C-reactive protein
3425:Beta-lactoglobulin
2707:, which is in the
2685:2019-09-13 at the
2102:10.1038/nm0396-287
1380:
1097:ENSMUSG00000059481
865:Biological process
799:Cellular component
755:hydrolase activity
735:peptidase activity
718:Molecular function
633:thoracic diaphragm
597:left lobe of liver
4833:
4832:
4542:
4541:
4339:Complement system
4131:Digestive enzymes
4077:
4076:
4073:
4072:
4020:Fibrin generation
3845:
3844:
3765:Extrinsic pathway
3710:Intrinsic pathway
3593:
3592:
3571:
3570:
3542:Alpha-lactalbumin
3442:Alpha-lactalbumin
3413:
3412:
3385:Fetal fibronectin
3351:
3350:
3268:
3267:
3125:Globular proteins
3091:
3090:
2515:(20): 2423–2434.
2439:(13): 6055–6059.
2398:(18): 9291–9297.
2314:10.1172/JCI111578
2257:(18): 2816–2829.
2178:(12): 2315–2322.
1844:(20): 6132–6136.
1793:(12): 2203–2206.
1635:missense mutation
1580:
1579:
1572:
1404:Graafian follicle
1400:complement system
1316:
1315:
1312:
1311:
1285:
1284:
1250:
1249:
1229:
1228:
1199:
1198:
1178:
1177:
1148:
1147:
1129:
1128:
1103:
1102:
1084:
1083:
1058:
1057:
1039:
1038:
987:
986:
917:blood coagulation
907:tissue remodeling
765:chaperone binding
702:
701:
698:
697:
653:
652:
640:
639:
578:
577:
476:
475:
375:
374:
202:
201:
198:
197:
50:Ortholog search:
4895:
4850:
4849:
4841:
4713:Hanes–Woolf plot
4656:Enzyme activator
4651:Enzyme inhibitor
4625:Enzyme catalysis
4569:
4562:
4555:
4546:
4545:
4104:
4097:
4090:
4081:
4080:
3965:
3964:
3640:
3639:
3620:
3613:
3606:
3597:
3596:
3467:
3466:
3311:
3287:
3284:carrier proteins
3279:
3278:
3240:
3208:
3205:carrier proteins
3158:
3150:
3149:
3141:
3140:
3118:
3111:
3104:
3095:
3094:
3077:
3062:
3047:
3032:
3017:
3002:
2987:
2972:
2957:
2942:
2927:
2912:
2897:
2882:
2867:
2852:
2837:
2822:
2807:
2792:
2777:
2762:
2742:
2735:
2728:
2719:
2718:
2663:
2646:(6): s294–s304.
2634:
2597:
2587:
2577:
2535:
2534:
2524:
2500:
2494:
2493:
2476:(2): E321–E331.
2465:
2459:
2458:
2448:
2424:
2418:
2417:
2407:
2383:
2377:
2376:
2366:
2342:
2336:
2335:
2325:
2308:(5): 1625–1633.
2293:
2287:
2286:
2276:
2266:
2242:
2236:
2235:
2207:
2198:
2197:
2187:
2163:
2157:
2156:
2139:(9): 2585–2593.
2128:
2122:
2121:
2085:
2079:
2078:
2068:
2058:
2026:
2020:
2019:
1983:
1977:
1976:
1966:
1942:
1931:
1930:
1912:
1888:
1882:
1881:
1871:
1861:
1829:
1823:
1822:
1812:
1802:
1778:
1772:
1771:
1764:
1755:
1754:
1743:
1737:
1736:
1725:
1719:
1709:
1698:
1688:
1652:Thrombospondin 1
1584:α2-macroglobulin
1575:
1568:
1564:
1561:
1555:
1524:
1516:
1432:serine proteases
1426:. Plasmin, like
1321:is an important
1298:
1297:
1269:
1262:
1245:
1233:
1232:
1224:
1208:
1207:
1204:RefSeq (protein)
1194:
1182:
1181:
1173:
1157:
1156:
1133:
1132:
1114:
1113:
1088:
1087:
1069:
1068:
1043:
1042:
1024:
1023:
993:
992:
708:
707:
694:
685:
678:
671:
664:
663:
649:
625:primitive streak
589:
587:Top expressed in
582:
581:
527:
525:Top expressed in
520:
519:
499:
498:
482:
481:
472:
459:
448:
433:
426:
420:
409:
397:
381:
380:
371:
358:
347:
332:
325:
319:
308:
294:
278:
277:
272:
223:
216:
193:
64:
63:
58:
37:
36:
31:
19:
18:
4903:
4902:
4898:
4897:
4896:
4894:
4893:
4892:
4858:
4857:
4856:
4844:
4836:
4834:
4829:
4741:Oxidoreductases
4727:
4703:Enzyme kinetics
4691:
4687:List of enzymes
4660:
4629:
4600:Catalytic triad
4578:
4573:
4543:
4538:
4440:
4417:
4383:
4333:
4170:
4139:Enteropeptidase
4125:
4108:
4078:
4069:
4059:
4042:
4014:
3986:
3954:
3944:
3935:
3888:
3841:
3784:
3767:(tissue factor)
3766:
3759:
3711:
3704:
3645:
3629:
3624:
3594:
3589:
3588:
3567:
3521:
3493:
3456:
3418:Other globulins
3409:
3369:
3365:Immunoglobulins
3347:
3309:
3304:
3301:
3282:
3264:
3238:
3233:
3203:
3198:
3153:
3145:Alpha globulins
3127:
3122:
3092:
3087:
3084:
3078:
3069:
3063:
3054:
3048:
3039:
3033:
3024:
3018:
3009:
3003:
2994:
2988:
2979:
2973:
2964:
2958:
2949:
2943:
2934:
2928:
2919:
2913:
2904:
2898:
2889:
2883:
2874:
2868:
2859:
2853:
2844:
2838:
2829:
2823:
2814:
2808:
2799:
2793:
2784:
2778:
2769:
2763:
2749:
2746:
2715:
2687:Wayback Machine
2671:
2666:
2543:
2541:Further reading
2538:
2501:
2497:
2466:
2462:
2425:
2421:
2384:
2380:
2343:
2339:
2294:
2290:
2243:
2239:
2208:
2201:
2164:
2160:
2129:
2125:
2090:Nature Medicine
2086:
2082:
2027:
2023:
1984:
1980:
1943:
1934:
1889:
1885:
1830:
1826:
1779:
1775:
1766:
1765:
1758:
1745:
1744:
1740:
1727:
1726:
1722:
1710:
1701:
1689:
1680:
1676:
1644:
1601:
1576:
1565:
1559:
1556:
1541:
1525:
1514:
1506:activation loop
1486:
1422:, laminin, and
1384:serine protease
1372:
1307:View/Edit Mouse
1302:View/Edit Human
1265:
1258:
1255:Location (UCSC)
1241:
1220:
1216:
1190:
1169:
1165:
1078:ENSG00000122194
971:
860:
841:plasma membrane
794:
740:protein binding
690:
680:
679:
673:
672:
645:
636:
631:
627:
623:
619:
615:
611:
607:
603:
599:
585:
574:
569:
565:
561:
557:
555:ascending aorta
553:
549:
545:
541:
537:
523:
467:
454:
446:
436:
435:
434:
427:
407:
384:Gene location (
366:
353:
345:
335:
334:
333:
326:
304:
281:Gene location (
270:PLG - orthologs
232:
219:
212:
73:
51:
17:
12:
11:
5:
4901:
4891:
4890:
4885:
4880:
4875:
4870:
4855:
4854:
4831:
4830:
4828:
4827:
4814:
4801:
4788:
4775:
4762:
4749:
4735:
4733:
4729:
4728:
4726:
4725:
4720:
4715:
4710:
4705:
4699:
4697:
4693:
4692:
4690:
4689:
4684:
4679:
4674:
4668:
4666:
4665:Classification
4662:
4661:
4659:
4658:
4653:
4648:
4643:
4637:
4635:
4631:
4630:
4628:
4627:
4622:
4617:
4612:
4607:
4602:
4597:
4592:
4586:
4584:
4580:
4579:
4572:
4571:
4564:
4557:
4549:
4540:
4539:
4537:
4536:
4535:
4534:
4529:
4519:
4514:
4505:
4491:
4486:
4481:
4480:
4479:
4474:
4464:
4459:
4454:
4448:
4446:
4442:
4441:
4439:
4438:
4433:
4427:
4425:
4419:
4418:
4416:
4415:
4410:
4405:
4400:
4394:
4392:
4385:
4384:
4382:
4381:
4376:
4375:
4374:
4369:
4359:
4354:
4349:
4343:
4341:
4335:
4334:
4332:
4331:
4330:
4329:
4324:
4314:
4302:
4301:
4300:
4299:
4294:
4289:
4284:
4279:
4274:
4269:
4264:
4259:
4254:
4249:
4244:
4239:
4234:
4229:
4224:
4214:
4209:
4204:
4199:
4194:
4189:
4180:
4178:
4172:
4171:
4169:
4168:
4167:
4166:
4161:
4151:
4146:
4141:
4135:
4133:
4127:
4126:
4111:Endopeptidases
4107:
4106:
4099:
4092:
4084:
4075:
4074:
4071:
4070:
4068:
4067:
4062:
4057:
4052:
4050:
4044:
4043:
4041:
4040:
4035:
4030:
4024:
4022:
4016:
4015:
4013:
4012:
4007:
4002:
3996:
3994:
3988:
3987:
3985:
3984:
3979:
3973:
3971:
3962:
3956:
3955:
3953:
3952:
3947:
3945:-Macroglobulin
3942:
3938:
3933:
3929:
3924:
3919:
3914:
3909:
3904:
3898:
3896:
3890:
3889:
3887:
3886:
3881:
3876:
3871:
3866:
3861:
3855:
3853:
3847:
3846:
3843:
3842:
3840:
3839:
3834:
3829:
3815:
3810:
3805:
3800:
3794:
3792:
3790:Common pathway
3786:
3785:
3783:
3782:
3777:
3771:
3769:
3761:
3760:
3758:
3757:
3752:
3747:
3742:
3737:
3732:
3727:
3722:
3716:
3714:
3706:
3705:
3703:
3702:
3697:
3691:
3682:
3676:
3671:
3656:
3650:
3648:
3637:
3631:
3630:
3623:
3622:
3615:
3608:
3600:
3591:
3590:
3587:
3586:
3577:
3576:
3573:
3572:
3569:
3568:
3566:
3565:
3560:
3555:
3550:
3545:
3535:
3529:
3527:
3523:
3522:
3520:
3519:
3514:
3509:
3503:
3501:
3495:
3494:
3492:
3491:
3486:
3481:
3475:
3473:
3464:
3458:
3457:
3455:
3454:
3449:
3444:
3439:
3434:
3433:
3432:
3421:
3419:
3415:
3414:
3411:
3410:
3408:
3407:
3402:
3400:Transcobalamin
3397:
3388:
3377:
3375:
3371:
3370:
3368:
3367:
3361:
3359:
3357:Gamma globulin
3353:
3352:
3349:
3348:
3346:
3345:
3340:
3335:
3330:
3325:
3320:
3314:
3312:
3306:
3305:
3303:
3302:
3296:
3290:
3288:
3276:
3274:Beta globulins
3270:
3269:
3266:
3265:
3263:
3262:
3251:
3243:
3241:
3235:
3234:
3232:
3231:
3226:
3219:
3211:
3209:
3200:
3199:
3197:
3196:
3186:
3176:
3161:
3159:
3147:
3138:
3129:
3128:
3121:
3120:
3113:
3106:
3098:
3089:
3088:
3086:
3085:
3079:
3072:
3070:
3064:
3057:
3055:
3049:
3042:
3040:
3034:
3027:
3025:
3019:
3012:
3010:
3004:
2997:
2995:
2989:
2982:
2980:
2974:
2967:
2965:
2959:
2952:
2950:
2944:
2937:
2935:
2929:
2922:
2920:
2914:
2907:
2905:
2899:
2892:
2890:
2884:
2877:
2875:
2869:
2862:
2860:
2854:
2847:
2845:
2839:
2832:
2830:
2824:
2817:
2815:
2809:
2802:
2800:
2794:
2787:
2785:
2779:
2772:
2770:
2764:
2757:
2754:
2751:
2750:
2745:
2744:
2737:
2730:
2722:
2700:
2699:
2689:
2670:
2669:External links
2667:
2665:
2664:
2635:
2598:
2544:
2542:
2539:
2537:
2536:
2495:
2460:
2419:
2378:
2357:(4): 976–982.
2337:
2288:
2237:
2218:(1): 193–198.
2199:
2158:
2123:
2096:(3): 287–292.
2080:
2021:
1994:(2): 541–557.
1978:
1957:(3): 185–190.
1932:
1903:(2): 254–260.
1883:
1824:
1773:
1756:
1738:
1720:
1699:
1677:
1675:
1672:
1643:
1640:
1600:
1597:
1588:α2-antiplasmin
1578:
1577:
1528:
1526:
1519:
1513:
1510:
1485:
1482:
1420:thrombospondin
1371:
1368:
1314:
1313:
1310:
1309:
1304:
1294:
1293:
1287:
1286:
1283:
1282:
1280:
1278:
1271:
1270:
1263:
1256:
1252:
1251:
1248:
1247:
1237:
1236:
1230:
1227:
1226:
1212:
1211:
1205:
1201:
1200:
1197:
1196:
1186:
1185:
1179:
1176:
1175:
1161:
1160:
1154:
1150:
1149:
1146:
1145:
1137:
1136:
1130:
1127:
1126:
1118:
1117:
1111:
1105:
1104:
1101:
1100:
1092:
1091:
1085:
1082:
1081:
1073:
1072:
1066:
1060:
1059:
1056:
1055:
1047:
1046:
1040:
1037:
1036:
1028:
1027:
1021:
1015:
1014:
1009:
1004:
1000:
999:
989:
988:
985:
984:
973:
972:
970:
969:
964:
959:
954:
949:
944:
939:
934:
929:
924:
919:
914:
909:
904:
899:
894:
889:
884:
879:
874:
868:
866:
862:
861:
859:
858:
853:
848:
843:
838:
833:
828:
823:
818:
813:
808:
802:
800:
796:
795:
793:
792:
790:kinase binding
787:
785:enzyme binding
782:
777:
772:
767:
762:
757:
752:
747:
742:
737:
732:
727:
721:
719:
715:
714:
704:
703:
700:
699:
696:
695:
687:
686:
661:
655:
654:
651:
650:
642:
641:
638:
637:
635:
634:
630:
626:
622:
621:abdominal wall
618:
614:
610:
606:
602:
598:
594:
591:
590:
579:
576:
575:
573:
572:
568:
564:
560:
556:
552:
548:
544:
540:
536:
532:
529:
528:
516:
515:
507:
496:
490:
489:
486:RNA expression
478:
477:
474:
473:
465:
461:
460:
452:
449:
444:
438:
437:
428:
421:
415:
411:
410:
405:
399:
398:
390:
389:
377:
376:
373:
372:
364:
360:
359:
351:
348:
343:
337:
336:
327:
320:
314:
310:
309:
302:
296:
295:
287:
286:
274:
273:
230:
226:
225:
217:
209:
208:
204:
203:
200:
199:
196:
195:
69:
68:
60:
59:
48:
42:
41:
33:
32:
24:
23:
15:
9:
6:
4:
3:
2:
4900:
4889:
4886:
4884:
4881:
4879:
4876:
4874:
4871:
4869:
4866:
4865:
4863:
4853:
4848:
4843:
4842:
4839:
4825:
4821:
4820:
4815:
4812:
4808:
4807:
4802:
4799:
4795:
4794:
4789:
4786:
4782:
4781:
4776:
4773:
4769:
4768:
4763:
4760:
4756:
4755:
4750:
4747:
4743:
4742:
4737:
4736:
4734:
4730:
4724:
4721:
4719:
4716:
4714:
4711:
4709:
4706:
4704:
4701:
4700:
4698:
4694:
4688:
4685:
4683:
4682:Enzyme family
4680:
4678:
4675:
4673:
4670:
4669:
4667:
4663:
4657:
4654:
4652:
4649:
4647:
4646:Cooperativity
4644:
4642:
4639:
4638:
4636:
4632:
4626:
4623:
4621:
4618:
4616:
4613:
4611:
4608:
4606:
4605:Oxyanion hole
4603:
4601:
4598:
4596:
4593:
4591:
4588:
4587:
4585:
4581:
4577:
4570:
4565:
4563:
4558:
4556:
4551:
4550:
4547:
4533:
4530:
4528:
4525:
4524:
4523:
4520:
4518:
4517:Streptokinase
4515:
4513:
4509:
4506:
4503:
4499:
4495:
4492:
4490:
4487:
4485:
4482:
4478:
4475:
4473:
4470:
4469:
4468:
4465:
4463:
4460:
4458:
4455:
4453:
4450:
4449:
4447:
4443:
4437:
4434:
4432:
4429:
4428:
4426:
4424:
4420:
4414:
4411:
4409:
4406:
4404:
4401:
4399:
4396:
4395:
4393:
4391:
4390:immune system
4386:
4380:
4379:C3-convertase
4377:
4373:
4370:
4368:
4365:
4364:
4363:
4360:
4358:
4355:
4353:
4350:
4348:
4345:
4344:
4342:
4340:
4336:
4328:
4325:
4323:
4320:
4319:
4318:
4315:
4313:
4310:
4308:
4304:
4303:
4298:
4295:
4293:
4290:
4288:
4285:
4283:
4280:
4278:
4275:
4273:
4270:
4268:
4265:
4263:
4260:
4258:
4255:
4253:
4250:
4248:
4245:
4243:
4240:
4238:
4235:
4233:
4230:
4228:
4225:
4223:
4220:
4219:
4218:
4215:
4213:
4210:
4208:
4205:
4203:
4200:
4198:
4195:
4193:
4190:
4188:
4185:
4182:
4181:
4179:
4177:
4173:
4165:
4162:
4160:
4157:
4156:
4155:
4152:
4150:
4147:
4145:
4142:
4140:
4137:
4136:
4134:
4132:
4128:
4123:
4120:
4116:
4112:
4105:
4100:
4098:
4093:
4091:
4086:
4085:
4082:
4066:
4063:
4061:
4054:
4053:
4051:
4049:
4045:
4039:
4036:
4034:
4031:
4029:
4026:
4025:
4023:
4021:
4017:
4011:
4008:
4006:
4003:
4001:
3998:
3997:
3995:
3993:
3989:
3983:
3980:
3978:
3975:
3974:
3972:
3970:
3966:
3963:
3961:
3957:
3951:
3948:
3946:
3939:
3937:
3930:
3928:
3925:
3923:
3920:
3918:
3915:
3913:
3910:
3908:
3905:
3903:
3900:
3899:
3897:
3895:
3891:
3885:
3882:
3880:
3877:
3875:
3872:
3870:
3867:
3865:
3862:
3860:
3857:
3856:
3854:
3852:
3848:
3838:
3835:
3833:
3830:
3827:
3823:
3819:
3816:
3814:
3811:
3809:
3806:
3804:
3801:
3799:
3796:
3795:
3793:
3791:
3787:
3781:
3778:
3776:
3773:
3772:
3770:
3768:
3762:
3756:
3753:
3751:
3748:
3746:
3743:
3741:
3738:
3736:
3733:
3731:
3730:Prekallikrein
3728:
3726:
3723:
3721:
3718:
3717:
3715:
3713:
3707:
3701:
3698:
3695:
3692:
3690:
3686:
3683:
3680:
3677:
3675:
3672:
3670:
3666:
3663:
3661:
3657:
3655:
3652:
3651:
3649:
3647:
3641:
3638:
3636:
3632:
3628:
3621:
3616:
3614:
3609:
3607:
3602:
3601:
3598:
3585:
3582:
3579:
3578:
3574:
3564:
3561:
3559:
3556:
3554:
3551:
3549:
3546:
3543:
3539:
3536:
3534:
3531:
3530:
3528:
3524:
3518:
3515:
3513:
3510:
3508:
3505:
3504:
3502:
3500:
3499:Serum albumin
3496:
3490:
3487:
3485:
3482:
3480:
3477:
3476:
3474:
3472:
3468:
3465:
3463:
3459:
3453:
3450:
3448:
3445:
3443:
3440:
3438:
3437:Thyroglobulin
3435:
3431:
3428:
3427:
3426:
3423:
3422:
3420:
3416:
3406:
3403:
3401:
3398:
3396:
3395:Microglobulin
3392:
3391:Macroglobulin
3389:
3386:
3382:
3379:
3378:
3376:
3372:
3366:
3363:
3362:
3360:
3358:
3354:
3344:
3341:
3339:
3336:
3334:
3331:
3329:
3326:
3324:
3321:
3319:
3316:
3315:
3313:
3307:
3300:
3297:
3295:
3292:
3291:
3289:
3285:
3280:
3277:
3275:
3271:
3260:
3256:
3252:
3249:
3245:
3244:
3242:
3236:
3230:
3227:
3224:
3223:Ceruloplasmin
3220:
3217:
3213:
3212:
3210:
3206:
3201:
3194:
3190:
3187:
3184:
3180:
3177:
3174:
3170:
3166:
3163:
3162:
3160:
3156:
3151:
3148:
3146:
3142:
3139:
3137:
3134:
3130:
3126:
3119:
3114:
3112:
3107:
3105:
3100:
3099:
3096:
3082:
3076:
3071:
3067:
3061:
3056:
3052:
3046:
3041:
3037:
3031:
3026:
3022:
3016:
3011:
3007:
3001:
2996:
2992:
2986:
2981:
2977:
2971:
2966:
2962:
2956:
2951:
2947:
2941:
2936:
2932:
2926:
2921:
2917:
2911:
2906:
2902:
2896:
2891:
2887:
2881:
2876:
2872:
2866:
2861:
2857:
2851:
2846:
2842:
2836:
2831:
2827:
2821:
2816:
2812:
2806:
2801:
2797:
2791:
2786:
2782:
2776:
2771:
2767:
2761:
2756:
2755:
2752:
2743:
2738:
2736:
2731:
2729:
2724:
2723:
2720:
2716:
2713:
2712:
2710:
2709:public domain
2706:
2697:
2693:
2690:
2688:
2684:
2681:
2677:
2673:
2672:
2661:
2657:
2653:
2649:
2645:
2641:
2636:
2632:
2628:
2624:
2620:
2616:
2612:
2608:
2604:
2599:
2595:
2591:
2586:
2581:
2576:
2571:
2567:
2563:
2559:
2555:
2551:
2546:
2545:
2532:
2528:
2523:
2518:
2514:
2510:
2506:
2499:
2491:
2487:
2483:
2479:
2475:
2471:
2464:
2456:
2452:
2447:
2442:
2438:
2434:
2430:
2423:
2415:
2411:
2406:
2401:
2397:
2393:
2389:
2382:
2374:
2370:
2365:
2360:
2356:
2352:
2348:
2341:
2333:
2329:
2324:
2319:
2315:
2311:
2307:
2303:
2299:
2292:
2284:
2280:
2275:
2270:
2265:
2260:
2256:
2252:
2248:
2241:
2233:
2229:
2225:
2221:
2217:
2213:
2206:
2204:
2195:
2191:
2186:
2181:
2177:
2173:
2169:
2162:
2154:
2150:
2146:
2142:
2138:
2134:
2127:
2119:
2115:
2111:
2107:
2103:
2099:
2095:
2091:
2084:
2076:
2072:
2067:
2062:
2057:
2052:
2048:
2044:
2040:
2036:
2032:
2025:
2017:
2013:
2009:
2005:
2001:
1997:
1993:
1989:
1982:
1974:
1970:
1965:
1960:
1956:
1952:
1948:
1941:
1939:
1937:
1928:
1924:
1920:
1916:
1911:
1906:
1902:
1898:
1894:
1887:
1879:
1875:
1870:
1865:
1860:
1855:
1851:
1847:
1843:
1839:
1835:
1828:
1820:
1816:
1811:
1806:
1801:
1796:
1792:
1788:
1784:
1777:
1769:
1763:
1761:
1752:
1748:
1742:
1734:
1730:
1724:
1717:
1713:
1708:
1706:
1704:
1696:
1692:
1687:
1685:
1683:
1678:
1671:
1669:
1665:
1661:
1657:
1653:
1649:
1639:
1636:
1631:
1629:
1625:
1621:
1617:
1613:
1608:
1606:
1596:
1593:
1589:
1585:
1574:
1571:
1563:
1560:November 2016
1553:
1549:
1545:
1539:
1538:
1534:
1529:This section
1527:
1523:
1518:
1517:
1509:
1507:
1501:
1497:
1495:
1491:
1481:
1479:
1474:
1472:
1468:
1464:
1460:
1456:
1452:
1446:
1444:
1440:
1435:
1433:
1429:
1425:
1421:
1417:
1413:
1409:
1406:, leading to
1405:
1401:
1397:
1393:
1389:
1385:
1382:Plasmin is a
1376:
1367:
1365:
1362:
1358:
1354:
1350:
1346:
1343:
1339:
1335:
1332:) present in
1331:
1328:
1324:
1320:
1308:
1303:
1299:
1295:
1292:
1288:
1281:
1279:
1276:
1272:
1268:
1264:
1261:
1257:
1253:
1246:
1244:
1238:
1234:
1231:
1225:
1223:
1219:
1213:
1209:
1206:
1202:
1195:
1193:
1187:
1183:
1180:
1174:
1172:
1168:
1162:
1158:
1155:
1153:RefSeq (mRNA)
1151:
1144:
1143:
1138:
1134:
1131:
1125:
1124:
1119:
1115:
1112:
1110:
1106:
1099:
1098:
1093:
1089:
1086:
1080:
1079:
1074:
1070:
1067:
1065:
1061:
1054:
1053:
1048:
1044:
1041:
1035:
1034:
1029:
1025:
1022:
1020:
1016:
1013:
1010:
1008:
1005:
1001:
998:
994:
990:
983:
979:
974:
968:
965:
963:
960:
958:
955:
953:
950:
948:
945:
943:
940:
938:
935:
933:
930:
928:
925:
923:
920:
918:
915:
913:
910:
908:
905:
903:
900:
898:
895:
893:
890:
888:
885:
883:
880:
878:
875:
873:
870:
869:
867:
864:
863:
857:
854:
852:
849:
847:
844:
842:
839:
837:
834:
832:
829:
827:
824:
822:
819:
817:
814:
812:
809:
807:
804:
803:
801:
798:
797:
791:
788:
786:
783:
781:
778:
776:
773:
771:
768:
766:
763:
761:
758:
756:
753:
751:
748:
746:
743:
741:
738:
736:
733:
731:
728:
726:
723:
722:
720:
717:
716:
713:
712:Gene ontology
709:
705:
693:
688:
684:
677:
670:
665:
662:
660:
656:
648:
643:
632:
628:
624:
620:
616:
612:
608:
604:
600:
596:
595:
592:
588:
583:
580:
570:
566:
562:
558:
554:
550:
546:
542:
539:kidney tubule
538:
534:
533:
530:
526:
521:
518:
517:
514:
512:
508:
506:
505:
501:
500:
497:
495:
491:
487:
483:
479:
471:
466:
462:
458:
453:
443:
439:
432:
425:
419:
412:
404:
400:
396:
391:
387:
382:
378:
370:
365:
361:
357:
352:
342:
338:
331:
324:
318:
311:
307:
301:
297:
293:
288:
284:
279:
275:
271:
267:
263:
259:
255:
251:
247:
243:
239:
235:
227:
222:
215:
210:
205:
194:
192:
188:
184:
180:
176:
172:
168:
164:
160:
156:
152:
148:
144:
140:
136:
132:
128:
124:
120:
116:
112:
108:
104:
100:
96:
92:
88:
84:
80:
76:
70:
65:
62:
61:
57:
54:
47:
43:
38:
34:
30:
25:
20:
4819:Translocases
4816:
4803:
4790:
4777:
4764:
4754:Transferases
4751:
4738:
4595:Binding site
4311:
4307:fibrinolysis
4305:
4183:
4149:Chymotrypsin
4065:D-Dimer (DD)
4048:Fibrinolysis
3936:-Antiplasmin
3906:
3658:
3580:
3337:
3189:Antithrombin
3080:
3065:
3050:
3035:
3020:
3005:
2990:
2975:
2960:
2945:
2930:
2915:
2900:
2885:
2870:
2855:
2840:
2825:
2810:
2795:
2780:
2765:
2714:
2702:
2701:
2652:10.2741/1044
2643:
2639:
2609:(1): 93–99.
2606:
2602:
2557:
2553:
2512:
2508:
2498:
2473:
2469:
2463:
2436:
2432:
2422:
2395:
2391:
2381:
2354:
2350:
2340:
2305:
2301:
2291:
2254:
2250:
2240:
2215:
2211:
2175:
2171:
2161:
2136:
2132:
2126:
2093:
2089:
2083:
2038:
2034:
2024:
1991:
1987:
1981:
1954:
1951:Cell Reports
1950:
1900:
1897:FEBS Letters
1896:
1886:
1841:
1837:
1827:
1790:
1786:
1776:
1750:
1741:
1732:
1723:
1645:
1642:Interactions
1632:
1623:
1609:
1602:
1581:
1566:
1557:
1542:Please help
1530:
1502:
1498:
1487:
1475:
1453:, including
1447:
1442:
1436:
1396:collagenases
1381:
1360:
1356:
1349:fibrinolysis
1338:blood plasma
1318:
1317:
1240:
1222:NP_001161810
1215:
1189:
1167:NM_001168338
1164:
1140:
1121:
1095:
1076:
1050:
1031:
1011:
1006:
927:fibrinolysis
816:cell surface
563:tibial nerve
547:human kidney
509:
502:
367:160,754,097
354:160,702,238
229:External IDs
72:
4590:Active site
4212:Factor XIIa
4192:Factor VIIa
4176:Coagulation
3902:Plasminogen
3837:Factor XIII
3755:Factor VIII
3548:Parvalbumin
3538:Lactalbumin
3430:Lactoferrin
3381:Fibronectin
3338:Plasminogen
3318:Angiostatin
3299:Transferrin
3259:Haptoglobin
3248:Orosomucoid
3216:Transcortin
2748:PDB gallery
2133:Circulation
1478:angiostatin
1443:plasminogen
1416:fibronectin
1392:proteolyses
1357:plasminogen
922:proteolysis
605:human fetus
601:gallbladder
468:12,638,272
455:12,597,495
207:Identifiers
4862:Categories
4793:Isomerases
4767:Hydrolases
4634:Regulation
4494:Subtilisin
4436:Batroxobin
4217:Kallikrein
4207:Factor XIa
4197:Factor IXa
4164:Pancreatic
4159:Neutrophil
3780:Factor VII
3735:Kallikrein
3725:Bradykinin
3517:Prealbumin
3479:Conalbumin
1718:, May 2017
1697:, May 2017
1674:References
1670:cleavage.
1664:bradykinin
1605:thrombosis
1592:sterically
1467:factor XII
1463:kallikrein
872:hemostasis
513:(ortholog)
250:HomoloGene
4883:EC 3.4.21
4672:EC number
4522:Cathepsin
4508:Sedolisin
4484:Prostasin
4202:Factor Xa
4056:Plasmin-α
3917:Urokinase
3750:Factor IX
3745:Factor XI
3484:Ovalbumin
3471:Egg white
3343:Properdin
3323:Hemopexin
3253:alpha-2 (
3246:alpha-1 (
3221:alpha-2 (
3214:alpha-1 (
3136:globulins
1599:Pathology
1531:does not
1459:urokinase
1408:ovulation
1243:NP_032903
1218:NP_000292
1192:NM_008877
1171:NM_000301
997:Orthologs
258:GeneCards
4696:Kinetics
4620:Cofactor
4583:Activity
4423:Venombin
4408:Tryptase
4403:Granzyme
4357:Factor I
4352:Factor D
4347:Factor B
4187:Thrombin
4184:factors:
4154:Elastase
3803:Factor V
3798:Factor X
3581:see also
3462:Albumins
3333:Factor H
2683:Archived
2660:12700073
2631:29248198
2623:11928826
2594:16006527
2531:27531677
2283:35100351
2232:29548426
2194:17900274
2118:29981847
2075:10611352
2016:73463150
2008:30837322
1973:22832192
1819:32594031
1714:–
1693:–
1648:interact
1618:(OMIM):
1370:Function
1355:form of
1330:3.4.21.7
1291:Wikidata
976:Sources:
609:yolk sac
559:testicle
4852:Biology
4806:Ligases
4576:Enzymes
4462:Pronase
4452:Acrosin
4398:Chymase
4312:Plasmin
4144:Trypsin
3907:Plasmin
3405:Edestin
3179:alpha-2
3165:alpha-1
3155:serpins
2692:Plasmin
2680:S01.233
2585:1177369
2562:Bibcode
2490:9688635
2455:2437112
2373:2522013
2332:6438154
2274:9074402
2153:7586361
2110:8612226
2043:Bibcode
1927:9075872
1919:3030813
1878:6216475
1846:Bibcode
1810:7749481
1716:Ensembl
1695:Ensembl
1633:A rare
1552:removed
1537:sources
1457:(tPA),
1451:enzymes
1441:called
1439:zymogen
1428:trypsin
1353:zymogen
1319:Plasmin
1109:UniProt
1064:Ensembl
1003:Species
982:QuickGO
488:pattern
214:Aliases
4838:Portal
4780:Lyases
4489:Reelin
4431:Ancrod
4388:Other
4122:3.4.21
3694:GPIIIa
3489:Avidin
3383:(fFN:
3310:other:
3239:other:
2698:(MeSH)
2676:MEROPS
2658:
2629:
2621:
2592:
2582:
2529:
2488:
2453:
2414:158022
2412:
2371:
2330:
2323:425339
2320:
2281:
2271:
2230:
2192:
2151:
2116:
2108:
2073:
2063:
2014:
2006:
1971:
1925:
1917:
1876:
1869:347073
1866:
1817:
1807:
1660:IGFBP3
1620:217090
1465:, and
1412:fibrin
1388:fibrin
1342:fibrin
1323:enzyme
1277:search
1275:PubMed
1142:P20918
1123:P00747
1019:Entrez
659:BioGPS
629:embryo
238:173350
4732:Types
4498:Furin
4445:Other
4372:MASP2
4367:MASP1
4297:KLK15
4292:KLK14
4287:KLK13
4282:KLK12
4277:KLK11
4272:KLK10
3689:GPIIb
3674:GP1BB
3669:GP1BA
3553:Ricin
3526:Other
3374:Other
3133:Serum
2627:S2CID
2509:Blood
2351:Blood
2251:Blood
2114:S2CID
2066:24787
2012:S2CID
1923:S2CID
1650:with
1345:clots
1334:blood
1052:18815
1012:Mouse
1007:Human
978:Amigo
571:gonad
511:Mouse
504:Human
451:Start
386:Mouse
350:Start
283:Human
254:55452
246:97620
4824:list
4817:EC7
4811:list
4804:EC6
4798:list
4791:EC5
4785:list
4778:EC4
4772:list
4765:EC3
4759:list
4752:EC2
4746:list
4739:EC1
4512:TPP1
4362:MASP
4267:KLK9
4262:KLK8
4257:KLK7
4252:KLK6
4247:KLK5
4242:KLK4
4237:KLK3
4232:KLK2
4227:KLK1
3081:5hpg
3066:2pk4
3051:2doi
3036:2doh
3021:1rjx
3006:1qrz
2991:1pmk
2976:1pkr
2961:1pk4
2946:1l4z
2931:1l4d
2916:1krn
2901:1ki0
2886:1i5k
2871:1hpk
2856:1hpj
2841:1ddj
2826:1ceb
2811:1cea
2796:1bui
2781:1bml
2766:1b2i
2674:The
2656:PMID
2619:PMID
2590:PMID
2527:PMID
2486:PMID
2451:PMID
2410:PMID
2369:PMID
2328:PMID
2279:PMID
2228:PMID
2190:PMID
2149:PMID
2106:PMID
2071:PMID
2004:PMID
1969:PMID
1915:PMID
1874:PMID
1815:PMID
1658:and
1586:and
1535:any
1533:cite
1364:gene
1033:5340
494:Bgee
442:Band
403:Chr.
346:6q26
341:Band
300:Chr.
234:OMIM
191:5HPG
187:4DUU
183:4DUR
179:4DCB
175:4CIK
171:4A5T
167:3UIR
163:2PK4
159:2L0S
155:2KNF
151:2DOI
147:2DOH
143:1RJX
139:1QRZ
135:1PMK
131:1PKR
127:1PK4
123:1L4Z
119:1L4D
115:1KRN
111:1KI0
107:1I5K
103:1HPK
99:1HPJ
95:1DDJ
91:1CEB
87:1CEA
83:1BUI
79:1BML
75:1B2I
56:RCSB
53:PDBe
4502:S1P
4222:PSA
3826:FGG
3822:FGA
2648:doi
2611:doi
2607:383
2580:PMC
2570:doi
2558:102
2517:doi
2513:128
2478:doi
2474:275
2441:doi
2437:262
2400:doi
2396:254
2359:doi
2318:PMC
2310:doi
2269:PMC
2259:doi
2255:139
2220:doi
2216:498
2180:doi
2141:doi
2098:doi
2061:PMC
2051:doi
1996:doi
1959:doi
1905:doi
1901:213
1864:PMC
1854:doi
1805:PMC
1795:doi
1624:PLG
1546:by
1361:PLG
464:End
363:End
266:OMA
262:PLG
242:MGI
221:PLG
46:PDB
22:PLG
4864::
4119:EC
4113::
3824:,
3257:,
3171:,
2654:.
2642:.
2625:.
2617:.
2605:.
2588:.
2578:.
2568:.
2556:.
2552:.
2525:.
2511:.
2507:.
2484:.
2472:.
2449:.
2435:.
2431:.
2408:.
2394:.
2390:.
2367:.
2355:73
2353:.
2349:.
2326:.
2316:.
2306:74
2304:.
2300:.
2277:.
2267:.
2253:.
2249:.
2226:.
2214:.
2202:^
2188:.
2174:.
2170:.
2147:.
2137:92
2135:.
2112:.
2104:.
2092:.
2069:.
2059:.
2049:.
2039:96
2037:.
2033:.
2010:.
2002:.
1992:47
1990:.
1967:.
1953:.
1949:.
1935:^
1921:.
1913:.
1899:.
1895:.
1872:.
1862:.
1852:.
1842:79
1840:.
1836:.
1813:.
1803:.
1791:15
1789:.
1785:.
1759:^
1749:.
1731:.
1702:^
1681:^
1654:,
1630:.
1480:.
1434:.
1418:,
1414:,
1366:.
1327:EC
980:/
470:bp
457:bp
369:bp
356:bp
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260::
256:;
252::
248:;
244::
240:;
236::
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4477:2
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