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The life span of nude mice is normally 6 months to a year. In controlled, germ free environments and with antibiotic treatments found in many laboratories that routinely use nude mice, they can live almost as long as normal mice (18 months to two years).
62:. The phenotype (main outward appearance) of the mouse is a lack of body hair, which gives it the "nude" nickname. The nude mouse is valuable to research because it can receive many different types of tissue and tumor grafts, as it mounts no
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Nude mice have a spontaneous deletion in the FOXN1 gene. (Humans with mutations in FOXN1 also are athymic and immune deficient.) Mice with a targeted deletion in the FOXN1 ("knockout" mice) also show the "nude" phenotype. Since
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are commonly used in research to test new methods of imaging and treating tumors. The genetic basis of the nude mouse mutation is a disruption of the
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The nomenclature for the nude mouse has changed several times since their discovery. Originally they were described as
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females have underdeveloped mammary glands and are unable to effectively nurse their young, nude males are bred with
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responsible for the mutation was identified as a member of the Fox gene family and the nomenclature was updated to
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Most strains of nude mice are slightly "leaky" and do have a few T cells, especially as they age. In addition,
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when the mutated gene was identified as a mutation in the HNF-3/forkhead homolog 11 gene. Then in 2000, the
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Because of the above features, nude mice have served in the laboratory to gain insights into the
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knockout mice). For these reasons, nude mice are less popular in research today.
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with more complete defects in the immune system have been constructed (e.g.
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Nude mice were first discovered in 1962 by Dr. Norman R. Grist at
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A nude mouse can accept tissue grafts from a variety of species
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114:. Because they lack a thymus, nude mice cannot generate mature
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The Nude Mouse in
Experimental and Clinical Research (Vol.2).
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The Nude Mouse in
Experimental and Clinical Research (Vol.1).
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Fogh, J; Giovanella, B.C.(eds) Academic Press, 1982,
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Fogh, J; Giovanella, B.C.(eds) Academic Press, 1978,
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199:(grafts of tissue from other mice) but also
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387:: CS1 maint: archived copy as title (
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307:"New Gene name for Nude Mice"
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402:Reference, Genetics Home.
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344:"Home | ari.info"
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78:Nomenclature
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34:A nude mouse
191:as well as
413:2018-10-09
374:2013-06-08
265:References
254:Skinny pig
201:xenografts
197:allografts
68:xenografts
40:nude mouse
239:Life span
235:females.
151:malignant
64:rejection
18:Nude mice
440:Category
383:cite web
330:(OMIM):
259:Earmouse
248:See also
222:Genetics
179:, solid
177:leukemia
193:leprosy
112:Glasgow
108:Ruchill
96:Foxn1nu
88:Hfh11nu
60:T cells
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181:tumors
74:gene.
52:thymus
368:(PDF)
361:(PDF)
72:FOXN1
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389:link
288:ISBN
275:ISBN
229:nude
216:RAG2
214:and
212:RAG1
185:AIDS
92:gene
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128:CD4
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