198:
294:: this consists of the core octamer of histones (H2A, H2B, H3 and H4) as well as a linker histone and about 180 base pairs of DNA. These core histones are rich in lysine and arginine residues. The carboxyl (C) terminal end of these histones contribute to histone-histone interactions, as well as histone-DNA interactions. The amino (N) terminal charged tails are the site of the post-translational modifications, such as the one seen in H3K4me1.
421:
The human genome was annotated with chromatin states. These annotated states can be used as new ways to annotate a genome independently of the underlying genome sequence. This independence from the DNA sequence enforces the epigenetic nature of histone modifications. Chromatin states are also useful
388:
revealed regions in the genome characterised by different banding. Different developmental stages were profiled in
Drosophila as well, an emphasis was placed on histone modification relevance. A look in to the data obtained led to the definition of chromatin states based on histone modifications.
383:
and the
Epigenomic roadmap. The purpose of the epigenomic study was to investigate epigenetic changes across the entire genome. This led to chromatin states which define genomic regions by grouping the interactions of different proteins and/or histone modifications together. Chromatin states were
329:
to control gene regulation. H3K4me3 in embryonic cells is part of a bivalent chromatin system, in which regions of DNA are simultaneously marked with activating and repressing histone methylations. This is believed to allow for a flexible system of gene expression, in which genes are primarily
227:. WDR5 associates specifically with dimethylated H3K4 and allows further methylation by methyltransferases, allowing for the creation and readout of the H3K4me3 modification. WDR5 activity has been shown to be required for developmental genes, like the
365:
When DNA damage occurs, DNA damage signalling and repair begins as a result of the modification of histones within the chromatin. Mechanistically, the demethylation of H3K4me3 is used required for specific protein binding and recruitment to DNA damage
460:) is used to investigate regions that are bound by well positioned nucleosomes. Use of the micrococcal nuclease enzyme is employed to identify nucleosome positioning. Well positioned nucleosomes are seen to have enrichment of sequences.
374:
The post-translational modification of histone tails by either histone modifying complexes or chromatin remodelling complexes are interpreted by the cell and lead to complex, combinatorial transcriptional output. It is thought that a
330:
repressed, but may be expressed quickly due to H3K4me3 as the cell progresses through development. These regions tend to coincide with transcription factor genes expressed at low levels. Some of these factors, such as the
389:
Certain modifications were mapped and enrichment was seen to localize in certain genomic regions. Five core histone modifications were found with each respective one being linked to various cell functions.
379:
dictates the expression of genes by a complex interaction between the histones in a particular region. The current understanding and interpretation of histones comes from two large scale projects:
262:
H3K4me3 promotes gene activation through the action of the NURF complex, a protein complex that acts through the PHD finger protein motif to remodel chromatin. This makes the DNA in the
1030:
Tesar PJ, Chenoweth JG, Brook FA, Davies TJ, Evans EP, Mack DL, et al. (July 2007). "New cell lines from mouse epiblast share defining features with human embryonic stem cells".
653:
Bernstein BE, Mikkelsen TS, Xie X, Kamal M, Huebert DJ, Cuff J, et al. (April 2006). "A bivalent chromatin structure marks key developmental genes in embryonic stem cells".
453:
to reveal DNA-protein binding occurring in cells. ChIP-Seq can be used to identify and quantify various DNA fragments for different histone modifications along a genomic region.
554:
Wysocka J, Swigut T, Xiao H, Milne TA, Kwon SY, Landry J, et al. (July 2006). "A PHD finger of NURF couples histone H3 lysine 4 trimethylation with chromatin remodelling".
239:
H3K4me3 is a commonly used histone modification. H3K4me3 is one of the least abundant histone modifications; however, it is highly enriched at active promoters near
1642:
112:. This is because this histone modification is found more in areas of the DNA that are associated with development and establishing cell identity.
204:
This diagram shows the progressive methylation of a lysine residue. The tri-methylation (right) denotes the methylation present in H3K4me3.
302:
Regulation of gene expression through H3K4me3 plays a significant role in stem cell fate determination and early embryo development.
1834:
1557:
Kundaje A, Meuleman W, Ernst J, Bilenky M, Yen A, Heravi-Moussavi A, et al. (Roadmap
Epigenomics Consortium) (February 2015).
883:"Distinct localization of histone H3 acetylation and H3-K4 methylation to the transcription start sites in the human genome"
1777:"DNase-seq: a high-resolution technique for mapping active gene regulatory elements across the genome from mammalian cells"
314:. A way of finding indicators of successful pluripotent induction is through comparing the epigenetic pattern to that of
1728:"Structured nucleosome fingerprints enable high-resolution mapping of chromatin architecture within regulatory regions"
1692:
1614:
1443:
Roy S, Ernst J, Kharchenko PV, Kheradpour P, Negre N, Eaton ML, et al. (modENCODE Consortium) (December 2010).
793:"WDR5 associates with histone H3 methylated at K4 and is essential for H3 K4 methylation and vertebrate development"
514:
Sims RJ, Nishioka K, Reinberg D (November 2003). "Histone lysine methylation: a signature for chromatin function".
97:
and expressed in the cell. More specifically, H3K4me3 is found to positively regulate transcription by bringing
438:
311:
252:
101:
and nucleosome remodelling enzymes (NURF). H3K4me3 also plays an important role in the genetic regulation of
39:
354:
pathway. It has been implicated that the binding of H3K4me3 is necessary for the function of genes such as
82:
1339:"Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project"
1184:"Histone H3K4me3 binding is required for the DNA repair and apoptotic activities of ING1 tumor suppressor"
605:
Santos-Rosa H, Schneider R, Bernstein BE, Karabetsou N, Morillon A, Weise C, et al. (November 2003).
426:. This additional level of annotation allows for a deeper understanding of cell specific gene regulation.
749:"Histone methyltransferases direct different degrees of methylation to define distinct chromatin domains"
1337:, Dutta A, GuigĂł R, Gingeras TR, Margulies EH, et al. (The ENCODE Project Consortium) (June 2007).
351:
208:
384:
investigated in
Drosophila cells by looking at the binding location of proteins in the genome. Use of
490:
1500:
Kharchenko PV, Alekseyenko AA, Schwartz YB, Minoda A, Riddle NC, Ernst J, et al. (March 2011).
667:
1294:
240:
197:
74:
1394:
Filion GJ, van Bemmel JG, Braunschweig U, Talhout W, Kind J, Ward LD, et al. (October 2010).
747:
Rice JC, Briggs SD, Ueberheide B, Barber CM, Shabanowitz J, Hunt DF, et al. (December 2003).
1334:
271:
94:
1396:"Systematic protein location mapping reveals five principal chromatin types in Drosophila cells"
1289:
1233:"Histone demethylase KDM5A regulates the ZMYND8-NuRD chromatin remodeler to promote DNA repair"
1135:"Histone methylation in DNA repair and clinical practice: new findings during the past 5-years"
662:
467:) is used to look in to regions that are nucleosome free (open chromatin). It uses hyperactive
1829:
1570:
1513:
1456:
1350:
1039:
894:
563:
480:
267:
90:
78:
69:
cells (including human cells), and modifications to the histone alter the accessibility of
706:
Bernstein BE, Mikkelsen TS, Xie X, Kamal M, Huebert DJ, Cuff J, et al. (April 2006).
8:
1726:
Schep AN, Buenrostro JD, Denny SK, Schwartz K, Sherlock G, Greenleaf WJ (November 2015).
832:
Ruthenburg AJ, Wang W, Graybosch DM, Li H, Allis CD, Patel DJ, Verdine GL (August 2006).
485:
423:
315:
282:
The genomic DNA of eukaryotic cells is wrapped around special protein molecules known as
215:
to histone H3. H3K4me3 is methylated by methyltransferase complexes containing a protein
47:
1574:
1517:
1460:
1354:
1043:
898:
567:
1801:
1776:
1752:
1727:
1703:
1668:
1591:
1558:
1534:
1501:
1477:
1445:"Identification of functional elements and regulatory circuits by Drosophila modENCODE"
1444:
1420:
1395:
1371:
1338:
1315:
1257:
1232:
1208:
1183:
1159:
1134:
1110:
1085:
1063:
966:
941:
858:
833:
791:
Wysocka J, Swigut T, Milne TA, Dou Y, Zhang X, Burlingame AL, et al. (June 2005).
688:
587:
446:
322:
917:
882:
765:
748:
708:"A bivalent chromatin structure marks key developmental genes in embryonic stem cells"
623:
607:"Methylation of histone H3 K4 mediates association of the Isw1p ATPase with chromatin"
606:
1806:
1757:
1708:
1688:
1596:
1539:
1482:
1425:
1376:
1307:
1262:
1213:
1164:
1115:
1055:
1012:
971:
922:
863:
814:
770:
729:
680:
628:
579:
531:
98:
1796:
1788:
1747:
1739:
1698:
1680:
1586:
1578:
1529:
1521:
1472:
1464:
1415:
1407:
1366:
1358:
1319:
1299:
1252:
1244:
1203:
1195:
1154:
1146:
1105:
1097:
1067:
1047:
1002:
961:
953:
912:
902:
853:
845:
804:
760:
719:
692:
672:
618:
591:
571:
523:
359:
224:
1684:
442:
385:
307:
834:"Histone H3 recognition and presentation by the WDR5 module of the MLL1 complex"
1411:
1007:
990:
887:
Proceedings of the
National Academy of Sciences of the United States of America
809:
792:
724:
707:
676:
468:
1502:"Comprehensive analysis of the chromatin landscape in Drosophila melanogaster"
1199:
1101:
527:
1823:
942:"Multivalent engagement of chromatin modifications by linked binding modules"
445:) measures the amount of DNA enrichment once bound to a targeted protein and
335:
256:
1468:
1303:
907:
881:
Liang G, Lin JC, Wei V, Yoo C, Cheng JC, Nguyen CT, et al. (May 2004).
334:, are essential for control development and cellular differentiation during
1810:
1761:
1712:
1600:
1543:
1486:
1429:
1380:
1311:
1266:
1217:
1168:
1119:
1059:
1016:
975:
926:
867:
818:
774:
733:
684:
632:
583:
535:
495:
376:
303:
244:
212:
109:
105:
43:
1743:
1248:
1182:
Peña PV, Hom RA, Hung T, Lin H, Kuo AJ, Wong RP, et al. (July 2008).
422:
in identifying regulatory elements that have no defined sequence, such as
346:
H3K4me3 is present at sites of DNA double-strand breaks where it promotes
243:(TSS) and positively correlated with transcription. H3K4me3 is used as a
1792:
220:
121:
73:
for transcription. H3K4me3 is commonly associated with the activation of
31:
1582:
1525:
1362:
1051:
575:
306:
have distinctive patterns of methylation that can be identified through
604:
347:
291:
248:
164:
77:
of nearby genes. H3K4 trimethylation regulates gene expression through
66:
55:
27:
23:
1231:
Gong F, Clouaire T, Aguirrebengoa M, Legube G, Miller KM (July 2017).
1150:
1669:"ATAC-seq: A Method for Assaying Chromatin Accessibility Genome-Wide"
849:
457:
287:
263:
102:
86:
1280:
Jenuwein T, Allis CD (August 2001). "Translating the histone code".
957:
1499:
1393:
464:
408:
402:
331:
326:
283:
228:
1332:
450:
414:
393:
1230:
434:
The histone mark H3K4me3 can be detected in a variety of ways:
380:
125:
51:
38:
residue of the histone H3 protein and is often involved in the
35:
286:. The complexes formed by the looping of the DNA are known as
1725:
1667:
Buenrostro JD, Wu B, Chang HY, Greenleaf WJ (January 2015).
1442:
1556:
463:
3. Assay for transposase accessible chromatin sequencing (
355:
325:, H3K4me3 is co-localized with the repressive modification
216:
70:
1666:
746:
705:
652:
1133:
Wei S, Li C, Yin Z, Wen J, Meng H, Xue L, Wang J (2018).
1029:
940:
Ruthenburg AJ, Li H, Patel DJ, Allis CD (December 2007).
831:
207:
The H3K4me3 modification is created by a lysine-specific
62:
1559:"Integrative analysis of 111 reference human epigenomes"
1086:"Bivalent histone modifications in early embryogenesis"
297:
939:
553:
277:
790:
513:
1719:
1079:
1077:
1615:"Whole-Genome Chromatin IP Sequencing (ChIP-Seq)"
648:
646:
644:
642:
1821:
1768:
1660:
1083:
290:. The basic structural unit of chromatin is the
1074:
1181:
880:
786:
784:
639:
549:
547:
545:
449:. It results in good optimization and is used
1279:
231:, that are regulated by histone methylation.
1774:
1126:
991:"Chromatin modifications and their function"
1132:
781:
542:
988:
369:
310:. This is important in the development of
26:modification to the DNA packaging protein
1800:
1751:
1702:
1590:
1533:
1476:
1419:
1370:
1293:
1256:
1207:
1158:
1109:
1006:
965:
916:
906:
857:
838:Nature Structural & Molecular Biology
808:
764:
723:
666:
622:
42:. The name denotes the addition of three
16:Histone methylation on tail of histone H3
1822:
1673:Current Protocols in Molecular Biology
1084:Vastenhouw NL, Schier AF (June 2012).
946:Nature Reviews. Molecular Cell Biology
471:to highlight nucleosome localisation.
1775:Song L, Crawford GE (February 2010).
190:
456:2. Micrococcal nuclease sequencing (
356:inhibitor of growth protein 1 (ING1)
298:Role in stem cells and embryogenesis
251:studies (usually identified through
234:
278:Understanding histone modifications
85:complex. This makes the DNA in the
13:
14:
1846:
362:and enact DNA repair mechanisms.
153:standard abbreviation for lysine
128:4 on histone H3 protein subunit:
481:Methamphetamine § Addiction
196:
1835:Post-translational modification
1635:
1607:
1550:
1493:
1436:
1387:
1326:
1273:
1224:
1175:
1090:Current Opinion in Cell Biology
1023:
982:
933:
161:position of amino acid residue
115:
989:Kouzarides T (February 2007).
874:
825:
740:
699:
598:
507:
312:induced pluripotent stem cells
184:number of methyl groups added
1:
1685:10.1002/0471142727.mb2129s109
766:10.1016/s1097-2765(03)00479-9
624:10.1016/s1097-2765(03)00438-6
501:
439:Chromatin immunoprecipitation
341:
253:chromatin immunoprecipitation
40:regulation of gene expression
1781:Cold Spring Harbor Protocols
1188:Journal of Molecular Biology
7:
1237:The Journal of Cell Biology
474:
274:and expressed in the cell.
270:, allowing the genes to be
93:, allowing the genes to be
10:
1851:
1412:10.1016/j.cell.2010.09.009
1008:10.1016/j.cell.2007.02.005
810:10.1016/j.cell.2005.03.036
725:10.1016/j.cell.2006.02.041
677:10.1016/j.cell.2006.02.041
429:
352:non-homologous end joining
1200:10.1016/j.jmb.2008.04.061
1102:10.1016/j.ceb.2012.03.009
528:10.1016/j.tig.2003.09.007
491:Histone methyltransferase
241:transcription start sites
211:(HMT) transferring three
209:histone methyltransferase
1469:10.1126/science.1198374
1304:10.1126/science.1063127
908:10.1073/pnas.0401866101
370:Epigenetic implications
145:H3 family of histones
61:H3 is used to package
1744:10.1101/gr.192294.115
1643:"MAINE-Seq/Mnase-Seq"
1335:Stamatoyannopoulos JA
1249:10.1083/jcb.201611135
268:transcription factors
255:) to identify active
219:, which contains the
91:transcription factors
1793:10.1101/pdb.prot5384
411:-polycomb repression
316:embryonic stem cells
89:more accessible for
79:chromatin remodeling
1787:(2): pdb.prot5384.
1679:: 21.29.1–21.29.9.
1583:10.1038/nature14248
1575:2015Natur.518..317.
1526:10.1038/nature09725
1518:2011Natur.471..480K
1461:2010Sci...330.1787R
1363:10.1038/nature05874
1355:2007Natur.447..799B
1052:10.1038/nature05972
1044:2007Natur.448..196T
899:2004PNAS..101.7357L
576:10.1038/nature04815
568:2006Natur.442...86W
486:Histone methylation
247:or histone mark in
30:that indicates tri-
516:Trends in Genetics
447:immunoprecipitated
323:bivalent chromatin
191:Lysine methylation
120:H3K4me3 indicates
99:histone acetylases
1455:(6012): 1787–97.
1349:(7146): 799–816.
1288:(5532): 1074–80.
1151:10.7150/jca.23427
1145:(12): 2072–2081.
1139:Journal of Cancer
399:H3K4me3-promoters
396:-primed enhancers
360:tumor suppressors
358:, which act as a
304:Pluripotent cells
235:Epigenetic marker
188:
187:
1842:
1815:
1814:
1804:
1772:
1766:
1765:
1755:
1723:
1717:
1716:
1706:
1664:
1658:
1657:
1655:
1653:
1639:
1633:
1632:
1630:
1628:
1619:
1611:
1605:
1604:
1594:
1569:(7539): 317–30.
1554:
1548:
1547:
1537:
1497:
1491:
1490:
1480:
1440:
1434:
1433:
1423:
1391:
1385:
1384:
1374:
1330:
1324:
1323:
1297:
1277:
1271:
1270:
1260:
1243:(7): 1959–1974.
1228:
1222:
1221:
1211:
1179:
1173:
1172:
1162:
1130:
1124:
1123:
1113:
1081:
1072:
1071:
1027:
1021:
1020:
1010:
986:
980:
979:
969:
937:
931:
930:
920:
910:
878:
872:
871:
861:
850:10.1038/nsmb1119
829:
823:
822:
812:
788:
779:
778:
768:
744:
738:
737:
727:
703:
697:
696:
670:
650:
637:
636:
626:
602:
596:
595:
551:
540:
539:
511:
417:-heterochromatin
200:
131:
130:
1850:
1849:
1845:
1844:
1843:
1841:
1840:
1839:
1820:
1819:
1818:
1773:
1769:
1738:(11): 1757–70.
1732:Genome Research
1724:
1720:
1695:
1665:
1661:
1651:
1649:
1641:
1640:
1636:
1626:
1624:
1617:
1613:
1612:
1608:
1555:
1551:
1512:(7339): 480–5.
1498:
1494:
1441:
1437:
1392:
1388:
1331:
1327:
1278:
1274:
1229:
1225:
1180:
1176:
1131:
1127:
1082:
1075:
1038:(7150): 196–9.
1028:
1024:
987:
983:
958:10.1038/nrm2298
938:
934:
893:(19): 7357–62.
879:
875:
830:
826:
789:
782:
745:
741:
704:
700:
668:10.1.1.328.9641
651:
640:
603:
599:
562:(7098): 86–90.
552:
543:
512:
508:
504:
477:
443:ChIP-sequencing
432:
386:ChIP-sequencing
372:
344:
300:
280:
266:accessible for
237:
193:
163:(counting from
118:
17:
12:
11:
5:
1848:
1838:
1837:
1832:
1817:
1816:
1767:
1718:
1693:
1659:
1634:
1606:
1549:
1492:
1435:
1386:
1325:
1295:10.1.1.453.900
1272:
1223:
1174:
1125:
1073:
1022:
1001:(4): 693–705.
981:
952:(12): 983–94.
932:
873:
824:
780:
753:Molecular Cell
739:
698:
638:
617:(5): 1325–32.
611:Molecular Cell
597:
541:
522:(11): 629–39.
505:
503:
500:
499:
498:
493:
488:
483:
476:
473:
469:Tn5 transposon
431:
428:
419:
418:
412:
406:
400:
397:
371:
368:
343:
340:
299:
296:
279:
276:
257:gene promoters
236:
233:
202:
201:
192:
189:
186:
185:
182:
178:
177:
174:
170:
169:
159:
155:
154:
151:
147:
146:
143:
139:
138:
135:
122:trimethylation
117:
114:
48:trimethylation
15:
9:
6:
4:
3:
2:
1847:
1836:
1833:
1831:
1828:
1827:
1825:
1812:
1808:
1803:
1798:
1794:
1790:
1786:
1782:
1778:
1771:
1763:
1759:
1754:
1749:
1745:
1741:
1737:
1733:
1729:
1722:
1714:
1710:
1705:
1700:
1696:
1694:9780471142720
1690:
1686:
1682:
1678:
1674:
1670:
1663:
1648:
1644:
1638:
1623:
1616:
1610:
1602:
1598:
1593:
1588:
1584:
1580:
1576:
1572:
1568:
1564:
1560:
1553:
1545:
1541:
1536:
1531:
1527:
1523:
1519:
1515:
1511:
1507:
1503:
1496:
1488:
1484:
1479:
1474:
1470:
1466:
1462:
1458:
1454:
1450:
1446:
1439:
1431:
1427:
1422:
1417:
1413:
1409:
1406:(2): 212–24.
1405:
1401:
1397:
1390:
1382:
1378:
1373:
1368:
1364:
1360:
1356:
1352:
1348:
1344:
1340:
1336:
1329:
1321:
1317:
1313:
1309:
1305:
1301:
1296:
1291:
1287:
1283:
1276:
1268:
1264:
1259:
1254:
1250:
1246:
1242:
1238:
1234:
1227:
1219:
1215:
1210:
1205:
1201:
1197:
1194:(2): 303–12.
1193:
1189:
1185:
1178:
1170:
1166:
1161:
1156:
1152:
1148:
1144:
1140:
1136:
1129:
1121:
1117:
1112:
1107:
1103:
1099:
1096:(3): 374–86.
1095:
1091:
1087:
1080:
1078:
1069:
1065:
1061:
1057:
1053:
1049:
1045:
1041:
1037:
1033:
1026:
1018:
1014:
1009:
1004:
1000:
996:
992:
985:
977:
973:
968:
963:
959:
955:
951:
947:
943:
936:
928:
924:
919:
914:
909:
904:
900:
896:
892:
888:
884:
877:
869:
865:
860:
855:
851:
847:
844:(8): 704–12.
843:
839:
835:
828:
820:
816:
811:
806:
803:(6): 859–72.
802:
798:
794:
787:
785:
776:
772:
767:
762:
759:(6): 1591–8.
758:
754:
750:
743:
735:
731:
726:
721:
718:(2): 315–26.
717:
713:
709:
702:
694:
690:
686:
682:
678:
674:
669:
664:
661:(2): 315–26.
660:
656:
649:
647:
645:
643:
634:
630:
625:
620:
616:
612:
608:
601:
593:
589:
585:
581:
577:
573:
569:
565:
561:
557:
550:
548:
546:
537:
533:
529:
525:
521:
517:
510:
506:
497:
494:
492:
489:
487:
484:
482:
479:
478:
472:
470:
466:
461:
459:
454:
452:
448:
444:
440:
435:
427:
425:
416:
413:
410:
407:
404:
401:
398:
395:
392:
391:
390:
387:
382:
378:
367:
363:
361:
357:
353:
349:
339:
337:
336:embryogenesis
333:
328:
324:
319:
317:
313:
309:
305:
295:
293:
289:
285:
275:
273:
269:
265:
260:
258:
254:
250:
246:
242:
232:
230:
226:
222:
218:
214:
213:methyl groups
210:
205:
199:
195:
194:
183:
180:
179:
176:methyl group
175:
172:
171:
168:
166:
160:
157:
156:
152:
149:
148:
144:
141:
140:
136:
133:
132:
129:
127:
123:
113:
111:
107:
104:
100:
96:
92:
88:
84:
80:
76:
75:transcription
72:
68:
64:
59:
57:
53:
49:
45:
44:methyl groups
41:
37:
33:
29:
25:
21:
1784:
1780:
1770:
1735:
1731:
1721:
1676:
1672:
1662:
1650:. Retrieved
1646:
1637:
1625:. Retrieved
1621:
1609:
1566:
1562:
1552:
1509:
1505:
1495:
1452:
1448:
1438:
1403:
1399:
1389:
1346:
1342:
1328:
1285:
1281:
1275:
1240:
1236:
1226:
1191:
1187:
1177:
1142:
1138:
1128:
1093:
1089:
1035:
1031:
1025:
998:
994:
984:
949:
945:
935:
890:
886:
876:
841:
837:
827:
800:
796:
756:
752:
742:
715:
711:
701:
658:
654:
614:
610:
600:
559:
555:
519:
515:
509:
496:Methyllysine
462:
455:
441:sequencing (
436:
433:
420:
405:-gene bodies
377:Histone code
373:
364:
345:
320:
301:
281:
261:
245:histone code
238:
206:
203:
162:
119:
116:Nomenclature
60:
19:
18:
1830:Epigenetics
272:transcribed
221:WD40 repeat
95:transcribed
34:at the 4th
32:methylation
1824:Categories
1652:23 October
1627:23 October
1333:Birney E,
502:References
342:DNA repair
292:nucleosome
249:epigenetic
165:N-terminus
67:eukaryotic
56:histone H3
28:Histone H3
24:epigenetic
1290:CiteSeerX
663:CiteSeerX
458:MNase-seq
424:enhancers
332:Hox genes
288:chromatin
264:chromatin
229:Hox genes
103:stem cell
87:chromatin
58:protein.
54:4 on the
50:) to the
1811:20150147
1762:26314830
1713:25559105
1647:illumina
1622:Illumina
1601:25693563
1544:21179089
1487:21177974
1430:20888037
1381:17571346
1312:11498575
1267:28572115
1218:18533182
1169:29937925
1120:22513113
1060:17597760
1017:17320507
976:18037899
927:15123803
868:16829959
819:15960974
775:14690610
734:16630819
685:16630819
633:14636589
584:16728976
536:14585615
475:See also
465:ATAC-seq
409:H3K27me3
403:H3K36me3
327:H3K27me3
308:ChIP-seq
284:histones
223:protein
137:Meaning
1802:3627383
1753:4617971
1704:4374986
1592:4530010
1571:Bibcode
1535:3109908
1514:Bibcode
1478:3192495
1457:Bibcode
1449:Science
1421:3119929
1372:2212820
1351:Bibcode
1320:1883924
1282:Science
1258:5496618
1209:2576750
1160:6010677
1111:3372573
1068:4430584
1040:Bibcode
967:4690530
895:Bibcode
859:4698793
693:9993008
592:4389087
564:Bibcode
451:in vivo
430:Methods
415:H3K9me3
394:H3K4me1
350:by the
110:lineage
106:potency
81:by the
20:H3K4me3
1809:
1799:
1760:
1750:
1711:
1701:
1691:
1599:
1589:
1563:Nature
1542:
1532:
1506:Nature
1485:
1475:
1428:
1418:
1379:
1369:
1343:Nature
1318:
1310:
1292:
1265:
1255:
1216:
1206:
1167:
1157:
1118:
1108:
1066:
1058:
1032:Nature
1015:
974:
964:
925:
918:409923
915:
866:
856:
817:
773:
732:
691:
683:
665:
631:
590:
582:
556:Nature
534:
381:ENCODE
348:repair
134:Abbr.
126:lysine
52:lysine
36:lysine
22:is an
1618:(PDF)
1316:S2CID
1064:S2CID
689:S2CID
588:S2CID
225:motif
71:genes
1807:PMID
1785:2010
1758:PMID
1709:PMID
1689:ISBN
1654:2019
1629:2019
1597:PMID
1540:PMID
1483:PMID
1426:PMID
1400:Cell
1377:PMID
1308:PMID
1263:PMID
1214:PMID
1165:PMID
1116:PMID
1056:PMID
1013:PMID
995:Cell
972:PMID
923:PMID
864:PMID
815:PMID
797:Cell
771:PMID
730:PMID
712:Cell
681:PMID
655:Cell
629:PMID
580:PMID
532:PMID
217:WDR5
108:and
83:NURF
1797:PMC
1789:doi
1748:PMC
1740:doi
1699:PMC
1681:doi
1677:109
1587:PMC
1579:doi
1567:518
1530:PMC
1522:doi
1510:471
1473:PMC
1465:doi
1453:330
1416:PMC
1408:doi
1404:143
1367:PMC
1359:doi
1347:447
1300:doi
1286:293
1253:PMC
1245:doi
1241:216
1204:PMC
1196:doi
1192:380
1155:PMC
1147:doi
1106:PMC
1098:doi
1048:doi
1036:448
1003:doi
999:128
962:PMC
954:doi
913:PMC
903:doi
891:101
854:PMC
846:doi
805:doi
801:121
761:doi
720:doi
716:125
673:doi
659:125
619:doi
572:doi
560:442
524:doi
437:1.
321:In
173:me
142:H3
124:of
65:in
63:DNA
1826::
1805:.
1795:.
1783:.
1779:.
1756:.
1746:.
1736:25
1734:.
1730:.
1707:.
1697:.
1687:.
1675:.
1671:.
1645:.
1620:.
1595:.
1585:.
1577:.
1565:.
1561:.
1538:.
1528:.
1520:.
1508:.
1504:.
1481:.
1471:.
1463:.
1451:.
1447:.
1424:.
1414:.
1402:.
1398:.
1375:.
1365:.
1357:.
1345:.
1341:.
1314:.
1306:.
1298:.
1284:.
1261:.
1251:.
1239:.
1235:.
1212:.
1202:.
1190:.
1186:.
1163:.
1153:.
1141:.
1137:.
1114:.
1104:.
1094:24
1092:.
1088:.
1076:^
1062:.
1054:.
1046:.
1034:.
1011:.
997:.
993:.
970:.
960:.
948:.
944:.
921:.
911:.
901:.
889:.
885:.
862:.
852:.
842:13
840:.
836:.
813:.
799:.
795:.
783:^
769:.
757:12
755:.
751:.
728:.
714:.
710:.
687:.
679:.
671:.
657:.
641:^
627:.
615:12
613:.
609:.
586:.
578:.
570:.
558:.
544:^
530:.
520:19
518:.
338:.
318:.
259:.
181:3
167:)
158:4
150:K
1813:.
1791::
1764:.
1742::
1715:.
1683::
1656:.
1631:.
1603:.
1581::
1573::
1546:.
1524::
1516::
1489:.
1467::
1459::
1432:.
1410::
1383:.
1361::
1353::
1322:.
1302::
1269:.
1247::
1220:.
1198::
1171:.
1149::
1143:9
1122:.
1100::
1070:.
1050::
1042::
1019:.
1005::
978:.
956::
950:8
929:.
905::
897::
870:.
848::
821:.
807::
777:.
763::
736:.
722::
695:.
675::
635:.
621::
594:.
574::
566::
538:.
526::
46:(
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
