143:. Other NURF mutants cause the development of melanotic tumors from larval blood cells. In humans, hNURF is involved in neuronal development and has been shown to enhance
92:
279:
Barak, Orr; Lazzaro, Maribeth A.; Lane, William S.; Speicher, David W.; Picketts, David J.; Shiekhattar, Ramin (2003-11-17).
219:
Badenhorst, Paul; Xiao, Hua; Cherbas, Lucy; Kwon, So Yeon; Voas, Matt; Rebay, Ilaria; Cherbas, Peter; Wu, Carl (2005-11-01).
44:
complexes. NURF is highly conserved among eukaryotes and is involved in transcriptional regulation of developmental genes.
107:, and pRBAP46/48, homologous to NURF301, NURF140, and NURF55, respectively. There is no human homolog for NURF38.
83:
contains four subunits: NURF301, NURF140, NURF55, and NURF38. NURF140 is an ISWI ATPase, distinguishable by its
576:
221:"The Drosophila nucleosome remodeling factor NURF is required for ecdysteroid signaling and metamorphosis"
67:. It was later discovered that NURF regulates transcription in this manner for hundreds of genes. A human
123:. NURF catalyzes nucleosome sliding in either direction on DNA without any apparent modifications to the
571:
30:
21:
120:
358:
57:
41:
8:
412:"ATP-Dependent Histone Octamer Sliding Mediated by the Chromatin Remodeling Complex NURF"
64:
362:
508:
Vignali, Marissa; Hassan, Ahmed H.; Neely, Kristen E.; Workman, Jerry L. (2000-03-15).
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346:
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220:
68:
542:
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308:
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248:
232:
186:
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genes. The ISWI ATPase specifically recognizes intact N-terminal histone tails. In
370:
124:
135:, NURF interacts with the transcription factor GAGA to remodel chromatin at the
175:"Purification and properties of an ATP-dependent nucleosome remodeling factor"
565:
533:
476:
378:
304:
244:
140:
128:
34:
19:(NURF) is an ATP-dependent chromatin remodeling complex first discovered in
551:
494:
437:
396:
322:
296:
262:
56:
by Toshio
Tsukiyama and Carl Wu in 1995. Tsukiyama and Wu described NURF’s
200:
410:
Hamiche, Ali; Sandaltzopoulos, Raphael; Gdula, David A; Wu, Carl (1999).
88:
84:
468:
236:
451:
Badenhorst, Paul; Voas, Matthew; Rebay, Ilaria; Wu, Carl (2002-12-15).
26:
453:"Biological functions of the ISWI chromatin remodeling complex NURF"
281:"Isolation of human NURF: a regulator of Engrailed gene expression"
148:
139:
promoter, and null mutations in the Nurf301 subunit prevent larval
116:
144:
104:
37:
409:
136:
95:(SANT-like but with several insertions). The NURF complex in
61:
100:
507:
218:
278:
450:
345:
Alkhatib, Suehyb G.; Landry, Joseph W. (2011-10-20).
115:
NURF interacts with chromatin by binding to modified
563:
127:itself. NURF is essential for the expression of
52:NURF was first purified from the model organism
510:"ATP-Dependent Chromatin-Remodeling Complexes"
344:
71:of NURF, called hNURF, was isolated in 2003.
172:
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484:
427:
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312:
252:
190:
40:, making it part of the ISWI family of
564:
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173:Tsukiyama, Toshio; Wu, Carl (1995).
168:
166:
164:
13:
347:"The Nucleosome Remodeling Factor"
29:sliding in order to regulate gene
14:
588:
329:
269:
207:
161:
526:10.1128/MCB.20.6.1899-1910.2000
514:Molecular and Cellular Biology
501:
444:
403:
1:
429:10.1016/s0092-8674(00)80796-5
371:10.1016/j.febslet.2011.09.003
154:
192:10.1016/0092-8674(95)90216-3
119:or interacting with various
74:
47:
17:Nucleosome Remodeling Factor
7:
110:
25:(fruit fly) that catalyzes
10:
593:
457:Genes & Development
225:Genes & Development
54:Drosophila melanogaster
22:Drosophila melanogaster
121:transcription factors
577:Nuclear organization
297:10.1093/emboj/cdg582
99:has three subunits,
79:The NURF complex in
58:chromatin remodeling
42:chromatin remodeling
469:10.1101/gad.1032202
363:2011FEBSL.585.3197A
237:10.1101/gad.1342605
572:Molecular biology
463:(24): 3186–3198.
357:(20): 3197–3207.
291:(22): 6089–6100.
231:(21): 2540–2545.
33:. It contains an
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556:
555:
545:
520:(6): 1899–1910.
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327:
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285:The EMBO Journal
276:
267:
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216:
205:
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185:(6): 1011–1020.
170:
60:activity on the
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125:histone octamer
113:
77:
50:
12:
11:
5:
590:
580:
579:
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558:
557:
500:
443:
422:(7): 833–842.
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141:metamorphosis
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93:SLIDE domains
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31:transcription
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351:FEBS Letters
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114:
97:Homo sapiens
96:
80:
78:
53:
51:
20:
16:
15:
566:Categories
155:References
147:outgrowth
133:Drosophila
81:Drosophila
27:nucleosome
534:0270-7306
477:0890-9369
379:1873-3468
305:0261-4189
245:0890-9369
75:Structure
48:Discovery
552:10688638
495:12502740
438:10399912
397:21920360
323:14609955
263:16264191
149:in vitro
129:homeotic
117:histones
111:Function
69:ortholog
65:promoter
388:4839296
359:Bibcode
254:1276728
201:8521501
145:neurite
550:
543:110808
540:
532:
493:
486:187504
483:
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377:
321:
314:275440
311:
303:
261:
251:
243:
199:
91:, and
38:ATPase
137:hsp70
105:SNF2L
62:hsp70
548:PMID
530:ISSN
491:PMID
473:ISSN
434:PMID
416:Cell
393:PMID
375:ISSN
319:PMID
301:ISSN
259:PMID
241:ISSN
197:PMID
179:Cell
101:BPTF
89:SANT
85:HAND
35:ISWI
538:PMC
522:doi
481:PMC
465:doi
424:doi
383:PMC
367:doi
355:585
309:PMC
293:doi
249:PMC
233:doi
187:doi
568::
546:.
536:.
528:.
518:20
516:.
512:.
489:.
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471:.
461:16
459:.
455:.
432:.
420:97
418:.
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365:.
353:.
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331:^
317:.
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289:22
287:.
283:.
271:^
257:.
247:.
239:.
229:19
227:.
223:.
209:^
195:.
183:83
181:.
177:.
163:^
151:.
103:,
87:,
554:.
524::
497:.
467::
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426::
399:.
369::
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235::
203:.
189::
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