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BPTF

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domain and a zinc finger motif, suggested it might play a role in the regulation of transcription. High levels of FAC1 were detected in fetal brain and in patients with neurodegenerative diseases. The protein encoded by this gene is actually much larger than originally thought, and it also contains a C-terminal bromodomain characteristic of proteins that regulate transcription during proliferation. The encoded protein is highly similar to the largest subunit of the Drosophila NURF (nucleosome remodeling factor) complex. In Drosophila, the NURF complex, which catalyzes nucleosome sliding on DNA and interacts with sequence-specific transcription factors, is necessary for the chromatin remodeling required for transcription. Two alternative transcripts encoding different isoforms have been described completely.
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This gene was identified by the reactivity of its encoded protein to a monoclonal antibody prepared against brain homogenates from patients with Alzheimer's disease. Analysis of the original protein (fetal Alz-50 reactive clone 1, or FAC1), identified as an 810 aa protein containing a DNA-binding
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Wysocka J, Swigut T, Xiao H, Milne TA, Kwon SY, Landry J, Kauer M, Tackett AJ, Chait BT, Badenhorst P, Wu C, Allis CD (July 2006). "A PHD finger of NURF couples histone H3 lysine 4 trimethylation with chromatin remodelling".
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Jordan-Sciutto K, Rhodes J, Bowser R (2002). "Altered subcellular distribution of transcriptional regulators in response to Abeta peptide and during Alzheimer's disease".
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Mu X, Springer JE, Bowser R (1997). "FAC1 expression and localization in motor neurons of developing, adult, and amyotrophic lateral sclerosis spinal cord".
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Rhodes J, Lutka FA, Jordan-Sciutto KL, Bowser R (2003). "Altered expression and distribution of FAC1 during NGF-induced neurite outgrowth of PC12 cells".
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Bowser R, Giambrone A, Davies P (1995). "FAC1, a novel gene identified with the monoclonal antibody Alz50, is developmentally regulated in human brain".
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Jordan-Sciutto KL, Dragich JM, Bowser R (1999). "DNA binding activity of the fetal Alz-50 clone 1 (FAC1) protein is enhanced by phosphorylation".
1722:"Fetal Alz-50 clone 1 (FAC1) protein interacts with the Myc-associated zinc finger protein (ZF87/MAZ) and alters its transcriptional activity" 1430:"Fetal Alz-50 clone 1 (FAC1) protein interacts with the Myc-associated zinc finger protein (ZF87/MAZ) and alters its transcriptional activity" 1271: 1253: 1108: 1101: 1489: 1324:
Jones MH, Hamana N, Shimane M (April 2000). "Identification and characterization of BPTF, a novel bromodomain transcription factor".
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Strachan GD, Ostrow LA, Jordan-Sciutto KL (2005). "Expression of the fetal Alz-50 clone 1 protein induces apoptotic cell death".
1414: 2371: 2390: 2217: 1236: 52: 1677:"Fetal Alz-50 clone 1, a novel zinc finger protein, binds a specific DNA sequence and acts as a transcriptional regulator" 1495: 1215: 1289:
Bowser R (March 1997). "Assignment of the human FAC1 gene to chromosome 17q24 by fluorescence in situ hybridization".
337: 314: 1240: 1219: 934: 2074:"The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)" 1580:
Zhu P, Bowser R (1997). "Identification and analysis of the complete cDNA sequence for the human FAC1 gene".
236: 211: 2276:: Crystal structure of PHD finger-linker-bromodomain fragment of human BPTF in the H3(1-15)K4ME2 bound state 2246:: Crystal structure of PHD finger-linker-bromodomain fragment of human BPTF in the H3(1-15)K4me3 bound state 915: 153: 1187: 2364: 350: 249: 2210: 343: 242: 2306:: NMR solution structure of the PHD domain from the human BPTF in complex with H3(1-15)K4me3 peptide 140: 2031:"Fetal Alz-50 clone 1 interacts with the human orthologue of the Kelch-like Ech-associated protein" 1035: 1027: 161: 1802:"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" 1065: 1061: 1031: 1006: 1002: 2146:"Molecular basis for site-specific read-out of histone H3K4me3 by the BPTF PHD finger of NURF" 2357: 225: 2261:: Crystal structure of PHD finger-linker-bromodomain fragment of human BPTF in the free form 2203: 2157: 1989: 1813: 1369: 181: 8: 1501: 2161: 1993: 1817: 1373: 2178: 2145: 2055: 2030: 1964: 1878: 1788: 1746: 1721: 1703: 1676: 1634: 1462: 1429: 1393: 185: 2098: 2073: 2012: 1977: 1916: 1891: 1836: 1801: 1776: 1593: 804: 799: 794: 789: 784: 779: 774: 769: 764: 759: 754: 749: 744: 739: 723: 718: 713: 708: 703: 698: 693: 688: 683: 678: 662: 657: 652: 647: 642: 637: 2183: 2132: 2103: 2060: 2017: 1956: 1921: 1870: 1866: 1841: 1780: 1751: 1708: 1663: 1626: 1597: 1568: 1533: 1467: 1449: 1385: 1341: 1306: 133: 45: 1968: 1882: 1792: 1638: 165: 2173: 2165: 2124: 2093: 2085: 2050: 2042: 2007: 1997: 1946: 1911: 1903: 1862: 1831: 1821: 1772: 1741: 1733: 1698: 1688: 1655: 1618: 1589: 1558: 1525: 1457: 1441: 1397: 1377: 1333: 1298: 430: 361: 305: 260: 1428:
Jordan-Sciutto, K L; Dragich J M; Caltagarone J; Hall D J; Bowser R (March 2000).
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National Center for Biotechnology Information, U.S. National Library of Medicine
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National Center for Biotechnology Information, U.S. National Library of Medicine
2341: 2128: 506: 2345: 1427: 2384: 2337: 1693: 1453: 624: 595: 2002: 1935:"Complete sequencing and characterization of 21,243 full-length human cDNAs" 1719: 1547:"Normalization and subtraction: two approaches to facilitate gene discovery" 566: 444: 2291:: NMR solution structure of PHD finger fragment of human BPTF in free state 2187: 2136: 2107: 2064: 2021: 1960: 1925: 1907: 1874: 1845: 1826: 1784: 1755: 1712: 1667: 1659: 1622: 1471: 1389: 1345: 1337: 1302: 588: 423: 202: 1975: 1630: 1601: 1572: 1537: 1310: 1148: 1143: 144:, FAC1, FALZ, NURF301, bromodomain PHD finger transcription factor, NEDDFL 960: 2169: 1381: 28: 2089: 1563: 1546: 1191: 322: 219: 169: 2046: 2028: 1799: 1737: 1529: 1445: 110: 106: 102: 98: 94: 90: 86: 82: 78: 74: 834: 389: 376: 288: 275: 177: 2071: 1978:"Large-scale characterization of HeLa cell nuclear phosphoproteins" 1951: 1934: 1892:"Isolation of human NURF: a regulator of Engrailed gene expression" 1132: 1720:
Jordan-Sciutto KL, Dragich JM, Caltagarone J, et al. (2000).
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Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004).
1852: 1415:"Entrez Gene: BPTF bromodomain PHD finger transcription factor" 1116: 856: 604: 2195: 1932: 2114: 2333: 2325: 1800:
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
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Jordan-Sciutto KL, Dragich JM, Rhodes JL, Bowser R (2000).
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positive regulation of transcription by RNA polymerase II
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negative regulation of transcription by RNA polymerase II
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Gerhard DS, Wagner L, Feingold EA, et al. (2004).
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Strachan GD, Morgan KL, Otis LL, et al. (2004).
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positive regulation of transcription, DNA-templated
1933:Ota T, Suzuki Y, Nishikawa T, et al. (2004). 1890:Barak O, Lazzaro MA, Lane WS, et al. (2004). 1323: 1232: 1230: 1228: 1211: 1209: 1207: 745:cellular response to nerve growth factor stimulus 360: 259: 2382: 1608: 800:regulation of transcription by RNA polymerase II 1225: 1204: 16:Protein-coding gene in the species Homo sapiens 1237:GRCm38: Ensembl release 89: ENSMUSG00000040481 2365: 2211: 1421: 1352: 1317: 1216:GRCh38: Ensembl release 89: ENSG00000171634 2372: 2358: 2218: 2204: 2144:Li H, Ilin S, Wang W, et al. (2006). 1282: 755:regulation of transcription, DNA-templated 2177: 2097: 2054: 2011: 2001: 1950: 1915: 1835: 1825: 1745: 1702: 1692: 1579: 1562: 1461: 1161:Nucleosome-remodeling factor subunit BPTF 1545:Bonaldo MF, Lennon G, Soares MB (1997). 1409: 1407: 1288: 790:anterior/posterior pattern specification 2383: 2199: 1404: 643:ATP-dependent activity, acting on DNA 365: 326: 321: 264: 223: 218: 2320: 13: 1508: 14: 2407: 1482: 1167:that in humans is encoded by the 2324: 2296: 2281: 2266: 2251: 2236: 1867:10.1097/00001756-200303030-00030 594: 587: 349: 342: 336: 313: 248: 241: 235: 210: 27: 2225: 1181: 704:perinuclear region of cytoplasm 2396:Human chromosome 17 gene stubs 1440:(12). UNITED STATES: 3206–15. 1264: 1246: 760:embryonic placenta development 605:More reference expression data 567:More reference expression data 475:right hemisphere of cerebellum 1: 2117:Biochem. Biophys. Res. Commun 1777:10.1016/S0047-6374(01)00334-7 1648:Biochem. Biophys. Res. Commun 1594:10.1016/s0167-4781(96)00127-3 1197: 638:sequence-specific DNA binding 334: 233: 2391:Genes on human chromosome 17 2344:. You can help Knowledge by 1982:Proc. Natl. Acad. Sci. U.S.A 1806:Proc. Natl. Acad. Sci. U.S.A 770:transcription, DNA-templated 648:transcription factor binding 7: 10: 2412: 2319: 2129:10.1016/j.bbrc.2005.08.127 1500:gene details page in the 1109:Chr 11: 106.92 – 107.02 Mb 663:methylated histone binding 2231: 1272:"Mouse PubMed Reference:" 1254:"Human PubMed Reference:" 1147: 1142: 1138: 1131: 1115: 1096: 1083: 1079: 1058: 1054: 1047: 1024: 1020: 999: 995: 988: 977: 973: 958: 954: 945: 932: 928: 913: 909: 900: 887: 883: 868: 864: 855: 840: 833: 829: 813: 623: 619: 602: 586: 577: 564: 553:medullary collecting duct 513: 504: 451: 442: 412: 404: 400: 383: 370: 333: 312: 303: 299: 282: 269: 232: 209: 200: 196: 151: 148: 138: 131: 126: 71: 66: 49: 44: 39: 35: 26: 21: 1694:10.1074/jbc.274.49.35262 1102:Chr 17: 67.83 – 67.98 Mb 529:Rostral migratory stream 2003:10.1073/pnas.0404720101 1186:BPTF has been shown to 541:external carotid artery 533:internal carotid artery 1827:10.1073/pnas.242603899 1660:10.1006/bbrc.1999.0986 1623:10.1006/exnr.1997.6508 1582:Biochim. Biophys. Acta 1338:10.1006/geno.1999.6070 1303:10.1006/geno.1996.0657 795:chromatin organization 50:Human UniProt search: 724:Set1C/COMPASS complex 714:extracellular exosome 471:cerebellar hemisphere 328:Chromosome 11 (mouse) 226:Chromosome 17 (human) 1908:10.1093/emboj/cdg582 1494:genome location and 785:response to wounding 750:endoderm development 740:chromatin remodeling 67:List of PDB id codes 40:Available structures 2170:10.1038/nature04802 2162:2006Natur.442...91L 1994:2004PNAS..10112130B 1818:2002PNAS...9916899M 1502:UCSC Genome Browser 1382:10.1038/nature04815 1374:2006Natur.442...86W 479:epithelium of colon 463:ganglionic eminence 2332:This article on a 2090:10.1101/gr.2596504 1564:10.1101/gr.6.9.791 935:ENSMUSG00000040481 733:Biological process 672:Cellular component 631:Molecular function 2353: 2352: 2314: 2313: 2047:10.1021/bi0494166 1812:(26): 16899–903. 1738:10.1021/bi992211q 1530:10.1159/000111270 1446:10.1021/bi992211q 1158: 1157: 1154: 1153: 1127: 1126: 1092: 1091: 1073: 1072: 1043: 1042: 1014: 1013: 984: 983: 967: 966: 941: 940: 922: 921: 896: 895: 877: 876: 825: 824: 780:brain development 709:neuron projection 653:metal ion binding 615: 614: 611: 610: 573: 572: 560: 559: 498: 497: 396: 395: 295: 294: 122: 121: 118: 117: 2403: 2374: 2367: 2360: 2328: 2321: 2300: 2285: 2270: 2255: 2240: 2220: 2213: 2206: 2197: 2196: 2191: 2181: 2140: 2111: 2101: 2068: 2058: 2041:(38): 12113–22. 2025: 2015: 2005: 1972: 1954: 1929: 1919: 1902:(22): 6089–100. 1886: 1849: 1839: 1829: 1796: 1765:Mech. Ageing Dev 1759: 1749: 1716: 1706: 1696: 1671: 1642: 1605: 1576: 1566: 1541: 1476: 1475: 1465: 1425: 1419: 1418: 1411: 1402: 1401: 1356: 1350: 1349: 1321: 1315: 1314: 1286: 1280: 1279: 1268: 1262: 1261: 1250: 1244: 1234: 1223: 1213: 1140: 1139: 1111: 1104: 1087: 1077: 1076: 1068: 1052: 1051: 1048:RefSeq (protein) 1038: 1018: 1017: 1009: 993: 992: 971: 970: 952: 951: 926: 925: 907: 906: 881: 880: 862: 861: 831: 830: 621: 620: 607: 598: 591: 584: 583: 569: 537:substantia nigra 509: 507:Top expressed in 502: 501: 459:ventricular zone 447: 445:Top expressed in 440: 439: 419: 418: 402: 401: 392: 379: 368: 353: 346: 340: 329: 317: 301: 300: 291: 278: 267: 252: 245: 239: 228: 214: 198: 197: 192: 190:BPTF - orthologs 143: 136: 113: 64: 63: 58: 37: 36: 31: 19: 18: 2411: 2410: 2406: 2405: 2404: 2402: 2401: 2400: 2381: 2380: 2379: 2378: 2317: 2315: 2310: 2307: 2301: 2292: 2286: 2277: 2271: 2262: 2256: 2247: 2241: 2227: 2224: 2194: 2084:(10B): 2121–7. 1988:(33): 12130–5. 1732:(12): 3206–15. 1687:(49): 35262–8. 1511: 1509:Further reading 1485: 1480: 1479: 1426: 1422: 1413: 1412: 1405: 1368:(7098): 86–90. 1357: 1353: 1322: 1318: 1287: 1283: 1270: 1269: 1265: 1252: 1251: 1247: 1235: 1226: 1214: 1205: 1200: 1184: 1149:View/Edit Mouse 1144:View/Edit Human 1107: 1100: 1097:Location (UCSC) 1085: 1064: 1060: 1034: 1030: 1026: 1005: 1001: 916:ENSG00000171634 809: 728: 667: 658:protein binding 603: 593: 592: 565: 556: 551: 547: 543: 539: 535: 531: 527: 523: 519: 505: 494: 489: 485: 481: 477: 473: 469: 467:corpus callosum 465: 461: 457: 443: 387: 374: 366: 356: 355: 354: 347: 327: 304:Gene location ( 286: 273: 265: 255: 254: 253: 246: 224: 201:Gene location ( 152: 139: 132: 73: 51: 17: 12: 11: 5: 2409: 2399: 2398: 2393: 2377: 2376: 2369: 2362: 2354: 2351: 2350: 2329: 2312: 2311: 2309: 2308: 2302: 2295: 2293: 2287: 2280: 2278: 2272: 2265: 2263: 2257: 2250: 2248: 2242: 2235: 2232: 2229: 2228: 2223: 2222: 2215: 2208: 2200: 2193: 2192: 2156:(7098): 91–5. 2141: 2112: 2069: 2026: 1973: 1952:10.1038/ng1285 1930: 1887: 1850: 1797: 1760: 1717: 1672: 1643: 1606: 1577: 1557:(9): 791–806. 1542: 1512: 1510: 1507: 1506: 1505: 1484: 1483:External links 1481: 1478: 1477: 1420: 1403: 1351: 1316: 1281: 1263: 1245: 1224: 1202: 1201: 1199: 1196: 1183: 1180: 1156: 1155: 1152: 1151: 1146: 1136: 1135: 1129: 1128: 1125: 1124: 1122: 1120: 1113: 1112: 1105: 1098: 1094: 1093: 1090: 1089: 1081: 1080: 1074: 1071: 1070: 1056: 1055: 1049: 1045: 1044: 1041: 1040: 1022: 1021: 1015: 1012: 1011: 997: 996: 990: 986: 985: 982: 981: 975: 974: 968: 965: 964: 956: 955: 949: 943: 942: 939: 938: 930: 929: 923: 920: 919: 911: 910: 904: 898: 897: 894: 893: 885: 884: 878: 875: 874: 866: 865: 859: 853: 852: 847: 842: 838: 837: 827: 826: 823: 822: 811: 810: 808: 807: 802: 797: 792: 787: 782: 777: 772: 767: 762: 757: 752: 747: 742: 736: 734: 730: 729: 727: 726: 721: 716: 711: 706: 701: 696: 691: 686: 681: 675: 673: 669: 668: 666: 665: 660: 655: 650: 645: 640: 634: 632: 628: 627: 617: 616: 613: 612: 609: 608: 600: 599: 581: 575: 574: 571: 570: 562: 561: 558: 557: 555: 554: 550: 546: 542: 538: 534: 530: 526: 522: 518: 514: 511: 510: 499: 496: 495: 493: 492: 488: 484: 480: 476: 472: 468: 464: 460: 456: 452: 449: 448: 436: 435: 427: 416: 410: 409: 406:RNA expression 398: 397: 394: 393: 385: 381: 380: 372: 369: 364: 358: 357: 348: 341: 335: 331: 330: 325: 319: 318: 310: 309: 297: 296: 293: 292: 284: 280: 279: 271: 268: 263: 257: 256: 247: 240: 234: 230: 229: 222: 216: 215: 207: 206: 194: 193: 150: 146: 145: 137: 129: 128: 124: 123: 120: 119: 116: 115: 69: 68: 60: 59: 48: 42: 41: 33: 32: 24: 23: 15: 9: 6: 4: 3: 2: 2408: 2397: 2394: 2392: 2389: 2388: 2386: 2375: 2370: 2368: 2363: 2361: 2356: 2355: 2349: 2347: 2343: 2339: 2338:chromosome 17 2335: 2330: 2327: 2323: 2322: 2318: 2305: 2299: 2294: 2290: 2284: 2279: 2275: 2269: 2264: 2260: 2254: 2249: 2245: 2239: 2234: 2233: 2230: 2221: 2216: 2214: 2209: 2207: 2202: 2201: 2198: 2189: 2185: 2180: 2175: 2171: 2167: 2163: 2159: 2155: 2151: 2147: 2142: 2138: 2134: 2130: 2126: 2122: 2118: 2113: 2109: 2105: 2100: 2095: 2091: 2087: 2083: 2079: 2075: 2070: 2066: 2062: 2057: 2052: 2048: 2044: 2040: 2036: 2032: 2027: 2023: 2019: 2014: 2009: 2004: 1999: 1995: 1991: 1987: 1983: 1979: 1974: 1970: 1966: 1962: 1958: 1953: 1948: 1944: 1940: 1936: 1931: 1927: 1923: 1918: 1913: 1909: 1905: 1901: 1897: 1893: 1888: 1884: 1880: 1876: 1872: 1868: 1864: 1861:(3): 449–52. 1860: 1856: 1851: 1847: 1843: 1838: 1833: 1828: 1823: 1819: 1815: 1811: 1807: 1803: 1798: 1794: 1790: 1786: 1782: 1778: 1774: 1770: 1766: 1761: 1757: 1753: 1748: 1743: 1739: 1735: 1731: 1727: 1723: 1718: 1714: 1710: 1705: 1700: 1695: 1690: 1686: 1682: 1681:J. Biol. Chem 1678: 1673: 1669: 1665: 1661: 1657: 1653: 1649: 1644: 1640: 1636: 1632: 1628: 1624: 1620: 1616: 1612: 1607: 1603: 1599: 1595: 1591: 1587: 1583: 1578: 1574: 1570: 1565: 1560: 1556: 1552: 1548: 1543: 1539: 1535: 1531: 1527: 1523: 1519: 1518:Dev. Neurosci 1514: 1513: 1503: 1499: 1498: 1493: 1492: 1487: 1486: 1473: 1469: 1464: 1459: 1455: 1451: 1447: 1443: 1439: 1435: 1431: 1424: 1416: 1410: 1408: 1399: 1395: 1391: 1387: 1383: 1379: 1375: 1371: 1367: 1363: 1355: 1347: 1343: 1339: 1335: 1331: 1327: 1320: 1312: 1308: 1304: 1300: 1296: 1292: 1285: 1277: 1273: 1267: 1259: 1255: 1249: 1242: 1238: 1233: 1231: 1229: 1221: 1217: 1212: 1210: 1208: 1203: 1195: 1193: 1189: 1179: 1175: 1173: 1170: 1166: 1162: 1150: 1145: 1141: 1137: 1134: 1130: 1123: 1121: 1118: 1114: 1110: 1106: 1103: 1099: 1095: 1088: 1082: 1078: 1075: 1069: 1067: 1063: 1057: 1053: 1050: 1046: 1039: 1037: 1033: 1029: 1023: 1019: 1016: 1010: 1008: 1004: 998: 994: 991: 989:RefSeq (mRNA) 987: 980: 976: 972: 969: 963: 962: 957: 953: 950: 948: 944: 937: 936: 931: 927: 924: 918: 917: 912: 908: 905: 903: 899: 892: 891: 886: 882: 879: 873: 872: 867: 863: 860: 858: 854: 851: 848: 846: 843: 839: 836: 832: 828: 821: 817: 812: 806: 803: 801: 798: 796: 793: 791: 788: 786: 783: 781: 778: 776: 773: 771: 768: 766: 763: 761: 758: 756: 753: 751: 748: 746: 743: 741: 738: 737: 735: 732: 731: 725: 722: 720: 717: 715: 712: 710: 707: 705: 702: 700: 697: 695: 692: 690: 687: 685: 682: 680: 677: 676: 674: 671: 670: 664: 661: 659: 656: 654: 651: 649: 646: 644: 641: 639: 636: 635: 633: 630: 629: 626: 625:Gene ontology 622: 618: 606: 601: 597: 590: 585: 582: 580: 576: 568: 563: 552: 549:Gonadal ridge 548: 544: 540: 536: 532: 528: 524: 520: 516: 515: 512: 508: 503: 500: 490: 486: 482: 478: 474: 470: 466: 462: 458: 454: 453: 450: 446: 441: 438: 437: 434: 432: 428: 426: 425: 421: 420: 417: 415: 411: 407: 403: 399: 391: 386: 382: 378: 373: 367:11|11 E1 363: 359: 352: 345: 339: 332: 324: 320: 316: 311: 307: 302: 298: 290: 285: 281: 277: 272: 262: 258: 251: 244: 238: 231: 227: 221: 217: 213: 208: 204: 199: 195: 191: 187: 183: 179: 175: 171: 167: 163: 159: 155: 147: 142: 135: 130: 125: 114: 112: 108: 104: 100: 96: 92: 88: 84: 80: 76: 70: 65: 62: 61: 57: 54: 47: 43: 38: 34: 30: 25: 20: 2346:expanding it 2331: 2316: 2303: 2288: 2273: 2258: 2243: 2153: 2149: 2123:(2): 490–5. 2120: 2116: 2081: 2077: 2038: 2035:Biochemistry 2034: 1985: 1981: 1942: 1938: 1899: 1895: 1858: 1854: 1809: 1805: 1771:(1): 11–20. 1768: 1764: 1729: 1726:Biochemistry 1725: 1684: 1680: 1654:(3): 785–9. 1651: 1647: 1617:(1): 17–24. 1614: 1610: 1588:(1–2): 5–8. 1585: 1581: 1554: 1550: 1524:(1): 20–37. 1521: 1517: 1496: 1490: 1437: 1434:Biochemistry 1433: 1423: 1365: 1361: 1354: 1329: 1325: 1319: 1297:(3): 455–7. 1294: 1290: 1284: 1275: 1266: 1257: 1248: 1185: 1182:Interactions 1176: 1168: 1160: 1159: 1084: 1059: 1036:NM_001359590 1028:NM_001080832 1025: 1000: 978: 959: 933: 914: 888: 869: 849: 844: 699:NURF complex 545:vas deferens 525:otic vesicle 521:otic placode 429: 422: 388:107,022,953 375:106,923,907 149:External IDs 72: 2226:PDB gallery 1945:(1): 40–5. 1855:NeuroReport 1611:Exp. Neurol 1332:(1): 35–9. 689:nucleoplasm 455:sural nerve 287:67,984,378 274:67,825,503 127:Identifiers 2385:Categories 2078:Genome Res 1939:Nat. Genet 1551:Genome Res 1243:, May 2017 1222:, May 2017 1198:References 491:left ovary 433:(ortholog) 170:HomoloGene 2336:on human 1454:0006-2960 1066:NP_872579 1062:NP_004450 1032:NM_176850 1007:NM_182641 1003:NM_004459 835:Orthologs 684:cell body 679:cytoplasm 178:GeneCards 2188:16728978 2137:16137655 2108:15489334 2065:15379550 2022:15302935 1969:21903526 1961:14702039 1926:14609955 1883:28755165 1875:12634501 1846:12477932 1793:34907508 1785:11640947 1756:10727212 1713:10575013 1668:10403843 1639:25924273 1472:10727212 1390:16728976 1346:10662542 1326:Genomics 1291:Genomics 1239:– 1218:– 1188:interact 1133:Wikidata 814:Sources: 694:dendrite 483:testicle 2179:4690523 2158:Bibcode 2056:3670950 1990:Bibcode 1814:Bibcode 1747:3667205 1704:3670955 1631:9225734 1602:8950167 1573:8889548 1538:7621746 1463:3667205 1398:4389087 1370:Bibcode 1311:8975731 1241:Ensembl 1220:Ensembl 1165:protein 947:UniProt 902:Ensembl 841:Species 820:QuickGO 719:nucleus 517:saccule 408:pattern 266:17q24.2 166:2444008 134:Aliases 2186:  2176:  2150:Nature 2135:  2106:  2099:528928 2096:  2063:  2053:  2020:  2013:514446 2010:  1967:  1959:  1924:  1917:275440 1914:  1896:EMBO J 1881:  1873:  1844:  1837:139241 1834:  1791:  1783:  1754:  1744:  1711:  1701:  1666:  1637:  1629:  1600:  1571:  1536:  1488:Human 1470:  1460:  1452:  1396:  1388:  1362:Nature 1344:  1309:  1119:search 1117:PubMed 961:Q12830 890:207165 857:Entrez 579:BioGPS 487:tonsil 174:114397 158:601819 2340:is a 1965:S2CID 1879:S2CID 1789:S2CID 1635:S2CID 1394:S2CID 1190:with 1163:is a 850:Mouse 845:Human 816:Amigo 431:Mouse 424:Human 371:Start 306:Mouse 270:Start 203:Human 2342:stub 2334:gene 2304:2fuu 2289:2fui 2274:2fsa 2259:2f6n 2244:2f6j 2184:PMID 2133:PMID 2104:PMID 2061:PMID 2018:PMID 1957:PMID 1922:PMID 1871:PMID 1842:PMID 1781:PMID 1752:PMID 1709:PMID 1664:PMID 1627:PMID 1598:PMID 1586:1309 1569:PMID 1534:PMID 1497:BPTF 1491:BPTF 1468:PMID 1450:ISSN 1386:PMID 1342:PMID 1307:PMID 1172:gene 1169:BPTF 871:2186 414:Bgee 362:Band 323:Chr. 261:Band 220:Chr. 182:BPTF 154:OMIM 141:BPTF 111:3UV2 107:3QZV 103:3QZT 99:3QZS 95:2RI7 91:2FUU 87:2FUI 83:2FSA 79:2F6N 75:2F6J 56:RCSB 53:PDBe 22:BPTF 2174:PMC 2166:doi 2154:442 2125:doi 2121:336 2094:PMC 2086:doi 2051:PMC 2043:doi 2008:PMC 1998:doi 1986:101 1947:doi 1912:PMC 1904:doi 1863:doi 1832:PMC 1822:doi 1773:doi 1769:123 1742:PMC 1734:doi 1699:PMC 1689:doi 1685:274 1656:doi 1652:260 1619:doi 1615:146 1590:doi 1559:doi 1526:doi 1458:PMC 1442:doi 1378:doi 1366:442 1334:doi 1299:doi 1192:MAZ 1086:n/a 979:n/a 384:End 283:End 186:OMA 162:MGI 46:PDB 2387:: 2182:. 2172:. 2164:. 2152:. 2148:. 2131:. 2119:. 2102:. 2092:. 2082:14 2080:. 2076:. 2059:. 2049:. 2039:43 2037:. 2033:. 2016:. 2006:. 1996:. 1984:. 1980:. 1963:. 1955:. 1943:36 1941:. 1937:. 1920:. 1910:. 1900:22 1898:. 1894:. 1877:. 1869:. 1859:14 1857:. 1840:. 1830:. 1820:. 1810:99 1808:. 1804:. 1787:. 1779:. 1767:. 1750:. 1740:. 1730:39 1728:. 1724:. 1707:. 1697:. 1683:. 1679:. 1662:. 1650:. 1633:. 1625:. 1613:. 1596:. 1584:. 1567:. 1553:. 1549:. 1532:. 1522:17 1520:. 1466:. 1456:. 1448:. 1438:39 1436:. 1432:. 1406:^ 1392:. 1384:. 1376:. 1364:. 1340:. 1330:63 1328:. 1305:. 1295:38 1293:. 1274:. 1256:. 1227:^ 1206:^ 1194:. 1174:. 818:/ 390:bp 377:bp 289:bp 276:bp 184:; 180:: 176:; 172:: 168:; 164:: 160:; 156:: 109:, 105:, 101:, 97:, 93:, 89:, 85:, 81:, 77:, 2373:e 2366:t 2359:v 2348:. 2219:e 2212:t 2205:v 2190:. 2168:: 2160:: 2139:. 2127:: 2110:. 2088:: 2067:. 2045:: 2024:. 2000:: 1992:: 1971:. 1949:: 1928:. 1906:: 1885:. 1865:: 1848:. 1824:: 1816:: 1795:. 1775:: 1758:. 1736:: 1715:. 1691:: 1670:. 1658:: 1641:. 1621:: 1604:. 1592:: 1575:. 1561:: 1555:6 1540:. 1528:: 1504:. 1474:. 1444:: 1417:. 1400:. 1380:: 1372:: 1348:. 1336:: 1313:. 1301:: 1278:. 1260:. 308:) 205:) 188::

Index


PDB
PDBe
RCSB
2F6J
2F6N
2FSA
2FUI
2FUU
2RI7
3QZS
3QZT
3QZV
3UV2
Aliases
BPTF
OMIM
601819
MGI
2444008
HomoloGene
114397
GeneCards
BPTF
OMA
BPTF - orthologs
Human
Chromosome 17 (human)
Chr.
Chromosome 17 (human)

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