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Cyanide poisoning

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1050:, as stated above. In humans, however, rhodanese is concentrated in the kidneys (0.96 units/mg protein) and liver (0.15 u/mg), with concentrations in lung, brain, muscle and stomach not exceeding 0.03 U/ml. In all these tissues, it is found in the mitochondrial matrix, a site of low accessibility for ionized, inorganic species, such as thiosulfate. This compartmentalization of rhodanese in mammalian tissues leaves major targets of cyanide lethality, namely, the heart and central nervous system, unprotected. Rhodanese is also found in red blood cells, but its relative importance has not been clarified.) 418: 1188: 5693: 53: 983:(4-DMAP) has been proposed in Germany as a more rapid antidote than nitrites with (reportedly) lower toxicity. 4-DMAP is used currently by the German military and by the civilian population. In humans, intravenous injection of 3 mg/kg of 4-DMAP produces 35 percent methemoglobin levels within 1 minute. Reportedly, 4-DMAP is part of the US Cyanokit, while it is not part of the German Cyanokit due to side effects (e. g. 5717: 5705: 3302: 678:
above 40 ÎĽmol per liter. Lactate levels greater than 6 mmol/L after reported or strongly suspected pure cyanide poisoning, such as cyanide-containing smoke exposure, suggests significant cyanide exposure. However, lactate alone is not diagnostic of cyanide poisoning because lactosis is also triggered by many other things, including mitochondrial dysfunction.
1695:(20 April 2013), a prominent 41-year-old neuroscientist and physician, died from cyanide poisoning. Klein's husband, Robert J. Ferrante, also a prominent neuroscientist who used cyanide in his research, was convicted of murder and sentenced to life in prison for her death. Robert Ferrante is appealing his conviction, claiming the cyanide was a false positive. 854:, and limited applicability (effective only in cases of cyanide ingestion, whereas the main modes of poisoning are inhalation and skin contact). The HSE has also questioned the usefulness of amyl nitrite due to storage/availability problems, risk of abuse, and lack of evidence of significant benefits. It also states that the availability of 1673:(1966–2012), won the lottery and was found dead a few days later. A blood diagnostic reported a lethal level of cyanide in his blood, but the body did not display any classic symptoms of cyanide poisoning, and no link to cyanide could be found in Urooj's social circle. The diagnostic method used was the Conway diffusion method, prone to 1035:, both of which are rich in sugar; thus, Rasputin would have been administered the poison together with massive quantities of antidote. One study found a reduction in cyanide toxicity in mice when the cyanide was first mixed with glucose. However, as yet glucose on its own is not an officially acknowledged antidote to cyanide poisoning. 1667:(1942–1988) Her husband, Richard Overton, was convicted of poisoning her, but Janet's symptoms did not match those of classic cyanide poisoning, the timeline was inconsistent with cyanide poisoning, and the amount found was just a trace. The diagnostic method used was prone to false positives. Richard Overton died in prison in 2009. 1290:
of Zyklon B sold in Germany in 1942–44, 56 tonnes (about eight percent of domestic sales) were sold to concentration camps. Auschwitz received 23.8 tonnes, of which six tonnes were used for fumigation. The remainder was used in the gas chambers or lost to spoilage (the product had a stated shelf life
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pathway. Cyanide poisoning inhibits aerobic respiration and therefore increases anaerobic glycolysis which causes a rise of lactate in the plasma. A lactate concentration above 10 mmol per liter is an indicator of cyanide poisoning, as defined by the presence of a blood cyanide concentration
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and supplied them with Zyklon B. They also offered courses to the SS in the safe handling and use of the material for fumigation purposes. In April 1941, the German agriculture and interior ministries designated the SS as an authorized applier of the chemical, and thus they were able to use it
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are quite toxic, and there have been accidents reported in the UK where patients have been given dicobalt-EDTA by mistake based on a false diagnosis of cyanide poisoning. Because of its side effects, it should be reserved only for patients with the most severe degree of exposure to cyanide;
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media, was arrested by the Thai police for allegedly poisoning 11 of her friends and acquaintances, spanning 2020 to 2023, with 10 deaths and 1 surviving supposed victim. According to an ongoing investigation, the number of victims is currently at 20-30 persons, mostly dead with several
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Heavy Water Plant in World War II (an attempt to stop or slow German atomic bomb progress), the commandos were given cyanide tablets (cyanide enclosed in rubber) kept in the mouth and were instructed to bite into them in case of German capture. The tablets ensured death within three
1467:. A total of 909 individuals died in Jonestown, many from apparent cyanide poisoning, in an event termed "revolutionary suicide" by Jones and some members on an audio tape of the event and in prior discussions. The poisonings in Jonestown followed the murder of five others by 1160:. After the fire, the technical institution INTI found that the level of toxicity due to the materials and volume of the building was 225 ppm of cyanide in the air. A lethal dose for rats is between 150 ppm and 220 ppm, meaning the air in the building was highly toxic. 934:(thiosulfate cyanide sulfurtransferase), which uses thiosulfate as a substrate. However, this reaction occurs too slowly in the body for thiosulfate to be adequate by itself in acute cyanide poisoning. Thiosulfate must therefore be used in combination with nitrites. 1126:
has historically been used as an antidote to cyanide poisoning, but is not a preferred therapy due to its theoretical risk of worsening of cyanide symptoms by displacement of cyanide from methemoglobin, allowing the toxin to bind to tissue electron transport
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or dicobalt-EDTA, sold as Kelocyanor. This agent chelates cyanide as the cobalticyanide. This drug provides an antidote effect more quickly than formation of methemoglobin, but a clear superiority to methemoglobin formation has not been demonstrated. Cobalt
1460:, was arrested. During the interrogations, Ogorodnik offered to write a full confession and asked for his pen. Inside the pen cap was a hidden cyanide pill, which when bitten on, caused Ogorodnik to die before he hit the floor, according to the Soviets. 1063:), which is more widely distributed in mammalian tissues than rhodanese, is being explored. 3-MPST converts cyanide to thiocyanate, using the cysteine catabolite, 3-mercaptopyruvate (3-MP). However, 3-MP is extremely unstable chemically. Therefore, a 1566:
In 2000, Allen Elias, CEO of Evergreen Resources was convicted of knowing endangerment for his role in the cyanide poisoning of employee Scott Dominguez. This was one of the first successful criminal prosecutions of a corporate executive by the
1727:, was arrested in 2019 for the murder of 6 family members. Murders took place over a 14-year period, and each victim ate a meal prepared by the killer. The murders were allegedly motivated by wanting control of the family finances and property. 1645:, was convicted of Tim's murder plus four counts of attempted murder. O'Bryan put potassium cyanide into five giant Pixy Stix that he gave to his son and daughter along with three other children. Only Timothy ate the poisoned candy and died. 4042: 641:
Cyanide is a broad-spectrum poison because the reaction it inhibits is essential to aerobic metabolism; COX is found in many forms of life. However, susceptibility to cyanide is far from uniform across affected species; for instance,
1737:, collapsed and died in April 2017, with cyanide later reported to be in her blood. However, Mei never exhibited symptoms of cyanide poisoning and no link to cyanide could be found in her life. Another likely false positive. 3964: 1026:
It has also been anecdotally suggested that glucose is itself an effective counteragent to cyanide, reacting with it to form less toxic compounds that can be eliminated by the body. One theory on the apparent immunity of
366:, and perceived difficulty in breathing. At the first stages of unconsciousness, breathing is often sufficient or even rapid, although the state of the person progresses towards a deep coma, sometimes accompanied by 4683: 4668: 3581: 282:. Blood levels of cyanide can be measured but take time. Levels of 0.5–1 mg/L are mild, 1–2 mg/L are moderate, 2–3 mg/L are severe, and greater than 3 mg/L generally result in death. 3800:". "The SS learned in 1944 that the expiration dates on the Zyklon tins were not hard and fast. All in all, it seems reasonable to assume that the SS over- rather than underdosed ..." —Peter Hayes 926:'s use is based on animal studies and case reports: the small quantities of cyanide present in dietary sources and in cigarette smoke are normally metabolized to relatively harmless thiocyanate by the 788:, sodium nitrite, 4-dimethylaminophenol, hydroxocobalamin, and dicobalt edetate ('Kelocyanor'), as well as several others. Another commonly-recommended antidote is 'solutions A and B' (a solution of 1024:
protects against cobalt toxicity associated with the antidote agent dicobalt edetate. For this reason, glucose is often administered alongside this agent (e.g. in the formulation 'Kelocyanor').
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Decontamination of people exposed to hydrogen cyanide gas only requires removal of the outer clothing and the washing of their hair. Those exposed to liquids or powders generally require
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roots; cassava is a staple food in various parts of West Africa) results in increased blood cyanide levels, which can result in weakness and a variety of symptoms, including permanent
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at the workplace may mislead doctors into treating a patient for cyanide poisoning when this is an erroneous diagnosis. The HSE no longer recommends a particular cyanide antidote.
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Suman SG, Gretarsdottir JM, Sigel A, Freisinger E, Sigel RK, Carver PL (2019). "Chapter 14. Chemical and Clinical Aspects of Metal-Containing Antidotes for Poisoning by Cyanide".
3891: 556:(also spelled hydroxycobalamin), might reduce the negative effects of chronic exposure; whereas, a deficiency might worsen negative health effects following exposure to cyanide. 3865: 1430:, and forced to undergo hormonal castration to avoid prison. An inquest determined that Turing's death from cyanide poisoning was a suicide, although this has been disputed. 724:
that cross-react with the pyridine-barbiturate assay. Meanwhile, the taurine-fluorescence-HPLC assay used for cyanide detection is identical to the assay used to detect
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Soviet officials initially stated that over four million people were murdered using Zyklon B at Auschwitz, but this figure was later proven to be greatly exaggerated.
1634: 1531: 5660: 3978: 3723: 3577: 3787: 2460: 381:. A fatal dose for humans can be as low as 1.5 mg/kg body weight. Other sources claim a lethal dose is 1–3 mg per kg body weight for vertebrates. 1692: 1246:, and by far the majority of these murders took place at Auschwitz. The constituents of Zyklon B were manufactured by several companies under licenses for 4416: 3366:
Aminlari M, Malekhusseini A, Akrami F, Ebrahimnejad H (2006). "Cyanide-metabolizing enzyme rhodanese in human tissues: Comparison with domestic animals".
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Sousa AB, Soto-Blanco B, Guerra JL, Kimura ET, Gorniak SL (2002). "Does prolonged oral exposure to cyanide promote hepatotoxicity and nephrotoxicity?".
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of cobalamin. It has greater affinity for the cyanide than cobalamin itself, which suggests that it could be a better option for emergency treatment.
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lasted from 1983 to 2009), used to wear cyanide vials around their necks with the intention of dying by suicide if captured by the government forces.
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issued a survey (IPCS/CEC Evaluation of Antidotes Series) that lists the following antidotal agents and their effects: oxygen, sodium thiosulfate,
634:, which can then compete with COX for free cyanide (as the cyanide will bind to the iron in its heme groups instead). Ferrihemoglobin cannot carry 4254: 1664: 4340: 4486: 1730: 4371: 1156:
on 30 December 2004, killing 194 people and leaving at least 1,492 injured. Most of the victims died from inhaling poisonous gases, including
638:, but the amount of ferrihemoglobin that can be formed without impairing oxygen transport is much greater than the amount of COX in the body. 1568: 2186: 1807: 1670: 4307: 3190: 2084: 1105:
cyanide quickly in low doses (smokers breathe in hydrogen cyanide, but it is such a small amount and metabolized so fast that it does not
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Alexander K, Procell LR, Kirby SD, Baskin SI (1989). "The inactivation of rhodanese by nitrite and inhibition by other anions in vitro".
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Baskin SI, Horowitz AM, Nealley EW (1992). "The antidotal action of sodium nitrite and sodium thiosulfate against cyanide poisoning".
354:, with death following in a matter of seconds. At lower doses, loss of consciousness may be preceded by general weakness, dizziness, 3242: 1145: 4372:"Sunset Park family reeling after they learn their matriarch had high levels of cyanide in her blood when she died – NY Daily News" 3861: 3014: 2258: 701: 2804:
Crampton RF, Gaunt IF, Harris R, et al. (1979). "Effects of low cobalamin diet and chronic cyanide toxicity in baboons".
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ions, being chemically similar to iron ions, can also bind cyanide. One current cobalt-based antidote available in Europe is
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which would otherwise occur at this stage. Therefore, cyanide interferes not only with aerobic respiration but also with the
4461: 4004: 259:, and certain seeds such as those of apples and apricots. Liquid forms of cyanide can be absorbed through the skin. Cyanide 4765: 4096: 3286: 1053: 3838: 2519:
Soto-Blanco B, Gorniak SL (2004). "Prenatal toxicity of cyanide in goats—a model for teratological studies in ruminants".
3982: 2747:"Evaluation of the health risks related to the presence of cyanogenic glycosides in foods other than raw apricot kernels" 1674: 1286:
and Testa to Auschwitz and Majdanek. Camps also occasionally bought Zyklon B directly from the manufacturers. Of the 729
1275: 1175:, caused the poisoning of hundreds of young people by cyanide released by the combustion of soundproofing foam made with 705: 3717: 4187: 3216: 2425:"Comparative effects of prolonged administration of cyanide, thiocyanate and chokecherry (Prunus virginiana) to goats" 1552:. In their memory, the National Environmental Conscious Day (DĂ­a Nacional de la Conciencia Ambiental) was established. 5202: 2859: 1427: 2482:
Soto-Blanco B, Maiorka PC, Gorniak SL (2002). "Neuropathologic study of long term cyanide administration to goats".
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used an apple that had been injected with a solution of cyanide to die by suicide after being convicted of having a
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Cyanide salts are sometimes used as fast-acting suicide devices. Cyanide reacts at a higher level with high stomach
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Soto-Blanco B, Maiorka PC, Gorniak SL (2002). "Effects of long-term low-dose cyanide administration to rats".
232:. Onset of symptoms usually occurs within a few minutes. Some survivors have long-term neurological problems. 5601: 5339: 5027: 2644:
Manzano H, de Sousa AB, Soto-Blanco B, et al. (2007). "Effects of long-term cyanide ingestion by pigs".
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Anseeuw K, Delvau N, Burillo-Putze G, De Iaco F, Geldner G, Holmström P, Lambert Y, Sabbe M (February 2013).
1698: 3105: 2877:"Interaction of Cyanide and Nitric Oxide with Cytochrome c Oxidase: Implications for Acute Cyanide Toxicity" 839:, a less toxic substance. Alternative methods of treating cyanide intoxication are used in other countries. 5157: 2484: 1652: 1556: 374: 5709: 5324: 4223: 3797: 1457: 1263: 682: 274:
Diagnosis is often difficult. It may be suspected in a person following a house fire who has a decreased
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The most widely studied cyanide-metabolizing pathway involves utilization of thiosulfate by the enzyme
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died by suicide by ingesting cyanide in a court anteroom immediately after being convicted of fraud.
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Nagler J, Provoost RA, Parizel G (1978). "Hydrogen cyanide poisoning: Treatment with cobalt EDTA".
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Forensic Toxicology: Principles and Concepts By Nicholas T Lappas, Courtney M Lappas, Chapter 10.
1642: 1628: 1080: 832: 2418: 2416: 1456:, a Soviet diplomat accused of spying on behalf of the Colombian Intelligence Agency and the US 389:
Exposure to lower levels of cyanide over a long period (e.g., after use of improperly processed
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with a remote controlled motor to rupture them, in what was believed to be an attempt by the
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have an alternative electron transfer pathway available that passes electrons directly from
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would become central to understanding the lethality of future gas chambers. In early 1942,
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If exposure is suspected, the person should be removed from the source of the exposure and
264: 256: 3578:"Número de pessoas mortas em incêndio em boate em Santa Maria, no RS, é revisado para 232" 3169: 1766: 8: 5697: 5636: 5360: 5319: 5126: 5079: 5022: 4847: 4821: 4687: 4155: 4149: 3234: 3127: 2532: 1637:(1966–1974) died on October 31, 1974, by ingesting potassium cyanide placed into a giant 1271: 1164: 1006: 729: 674: 442: 434: 417: 306: 2817: 2614: 2390: 2030:
Hamel J (February 2011). "A review of acute cyanide poisoning with a treatment update".
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system. The attack was supposedly aborted because there would not be enough casualties.
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Cyanide poisoning can result from the ingestion of cyanide salts, imbibing pure liquid
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Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic
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ingested a cyanide pill seconds after a guilty verdict was read in his arson trial in
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Hanzlik PJ (4 February 1933). "Methylene blue as an antidote for cyanide poisoning".
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in some states of the United States, where cyanide was generated by reaction between
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owing to unknown chemical nerve agents. Hydrogen cyanide gas was strongly suspected.
1412: 846:(HSE) has recommended against the use of solutions A and B because of their limited 5220: 5182: 5177: 5112: 5005: 4900: 4524: 3549: 3541: 3500: 3492: 3453: 3410: 3375: 3267: 3068: 3052: 2977: 2969: 2888: 2821: 2768: 2758: 2700: 2673: 2653: 2618: 2567: 2528: 2493: 2436: 2394: 2341: 2151: 2111: 2039: 1979: 1759: 1587: 1519: 1502: 1434: 1404: 1028: 1001: 992: 944: 939: 820: 797: 553: 363: 335: 294: 236: 181: 4738: 5399: 5187: 5107: 4905: 4887: 4703: 4572: 4491: 4468: 4449:
Chemical and Biological Warfare: A Comprehensive Survey for the Concerned Citizen
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Bomb: The Race to Build â€“ and Steal â€“ the World's Most Dangerous Weapon
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died in custody after having ingested cyanide pills he had sewn into his clothes.
1479:, an act that Jones ordered. Four other Temple members died by murder-suicide in 1446: 1350: 1343: 1157: 1106: 789: 367: 290: 248: 177: 173: 145: 4093: 3029: 2142:
Thompson JP, Marrs TC (December 2012). "Hydroxocobalamin in cyanide poisoning".
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of it). This prevents electrons passing through COX from being transferred to O
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and Sue Snow (5 June 1986) Murdered by Stella Nickell who poisoned bottles of
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On 22 June 2015, John B. McLemore, a horologist and the central figure of the
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Nagasawa HT, Goon DJ, Crankshaw DL, Vince R, Patterson SE (December 2007).
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Leavesley HB, Li L, Prabhakaran K, Borowitz JL, Isom GE (January 2008).
5626: 5524: 5486: 5423: 5387: 5352: 5014: 3365: 3345:"ValoraciĂłn de la glucosa como antĂ­doto en la intoxicaciĂłn por cianuro" 2043: 1622: 1545: 1283: 1076: 1068: 1060: 855: 847: 748: 647: 627: 371: 244: 141: 73: 4660: 3545: 2345: 5646: 5586: 5539: 5448: 5435: 5392: 5375: 5299: 4950: 4915: 4783: 4733: 3979:"Who is John B. McLemore, figure in new 'S-Town' podcast? (spoilers)" 3946:
Former CIA Chief of Disguise Breaks Down Cold War Spy Gadgets | Wired
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to cyanide was that his killers put the poison in sweet pastries and
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Gerardo I, Ilsen R, Ernesto I, Egar S, Magaly T, Marcelo G (2005).
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In 1993, an illegal spill resulted in the death of seven people in
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Evidence from animal experiments suggests that coadministration of
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is not innocuous as methemoglobin cannot carry oxygen, and severe
743:), which are considered specific tests. Since cyanide has a short 5665: 5574: 5291: 4936: 4518: 4341:"Woman in India admits poisoning six family members with cyanide" 3749:. Berkeley, Calif.: University of California Press. p. 166. 1965: 1706: 1509: 1335: 1247: 1064: 1021: 1015: 948: 899:, thus releasing cyanide from cytochrome oxidase. Treatment with 882: 872: 694: 619: 537: 496: 422: 390: 213: 197: 128: 60: 5664:
is generally non-toxic metal, but in large doses it can lead to
4308:"Pittsburgh researcher convicted of poisoning wife with cyanide" 2556:"Fetal and maternal lesions of cyanide dosing to pregnant goats" 1230:. The chemical was used to murder roughly one million people in 823:
was approved for use in the US in late 2006 and is available in
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The gas is directly released from canisters (e.g., as part of a
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Crankshaw DL, Goon DJ, Briggs JE, et al. (December 2007).
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Soto-Blanco B, Stegelmeier BL, Pfister JA, et al. (2008).
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Ballhorn DJ (2011). "Cyanogenic Glycosides in Nuts and Seeds".
1720: 1559:, resulted in the worst environmental disaster in Europe since 1512: 1372: 1172: 997: 886: 670: 643: 635: 398: 268: 4601:. Cambridge; New York; Melbourne: Cambridge University Press. 4286:"The Ferrante trial: A look inside the cyanide poisoning case" 3347:[Rating glucose as an antidote in cyanide poisoning]. 2955: 2874: 5758:
Toxic effects of substances chiefly nonmedicinal as to source
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Methods of detection include colorimetric assays such as the
599:, it also interferes with the pumping of a proton out of the 347: 240: 4184:
Alternative Considerations of Jonestown & Peoples Temple
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The last gasp: the rise and fall of the American gas chamber
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The Last Gasp: The Rise and Fall of the American Gas Chamber
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Oke OL (1969). "The role of hydrocyanic acid in nutrition".
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into 2 molecules of 3-MP after being administered orally or
377:. Despite the similar name, cyanide does not directly cause 4447:
Eric Croddy with Clarisa Perez-Armendariz & John Hart,
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Castresana J, LĂĽbben M, Saraste M, Higgins DG (June 1994).
1784: 1291:
of only three months). Testa conducted fumigations for the
1243: 1242:, and elsewhere. Most of the people who were murdered were 693:
assay, also known as the "Conway diffusion method" and the
584: 339: 309:
may also be given. Historically, cyanide has been used for
260: 4599:
From Cooperation to Complicity: Degussa in the Third Reich
4487:"The Untold Story of al-Qaeda's Plot to Attack the Subway" 3527: 2643: 1383:(a historical name for hydrogen cyanide), was the favored 503:
As potential contributing factors, cyanide is present in:
196:
that results from exposure to any of a number of forms of
3228: 3226: 2554:
Soto-Blanco B, Pereira, Verechia FT, et al. (2009).
2481: 2376: 2187:"Imported Bitter Apricot Pits Recalled as Cyanide Hazard" 1532:
International Criminal Tribunal for the former Yugoslavia
3763: 1327:
For information on methods of suicide intervention, see
1296:
without any further training or governmental oversight.
3673: 3342: 4577:
Holocaust: The Nazi Persecution and Murder of the Jews
3223: 1765:
In 1995, a device was discovered in a restroom in the
409:. Other effects include mild liver and kidney damage. 267:, resulting in the body's tissues being unable to use 4780: 3400: 3315: 3035: 2745:
EFSA Panel on Contaminants in the Food Chain (2019).
2222:. The American Society of Health-System Pharmacists. 1701:
died in hospital on 6 January 2016, after drinking a
1353:
died by suicide by drinking cyanide at a hospital in
654:, which confers cyanide resistance by bypassing COX. 4650: 3815: 3803: 3775: 3697: 3685: 3106:"Antidotes for Poisoning by Cyanide: 6. myl Nitrite" 1758:
In 1988, between 3,200 and 5,000 people died in the
704:
but like all colorimetric assays these are prone to
3478: 2803: 1794:reportedly planned to release cyanide gas into the 1349:In February 1937, the Uruguayan short story writer 1274:, with Heli supplying it to concentration camps at 835:, detoxifies cyanide and converts the cyanide into 216:, and vomiting. This phase may then be followed by 4632:. Bloomington: Indiana University Press. pp.  4625: 4141: 2849: 2518: 1342:On 26 January 1904, company promoter and swindler 831:, which could be delivered to the body through an 735:Cyanide and thiocyanate assays have been run with 4222: 3110:IPCS/CEC Evaluation of Antidotes Series; Volume 2 1787:to produce toxic amounts of hydrogen cyanide gas. 958:made by bacteria, and sometimes denoted vitamin B 487:or any similar scenario involving the burning of 5739: 4147: 3605:"U.S. rushing treatment for Brazil fire victims" 3602: 1179:. By March 2013, 245 fatalities were confirmed. 4224:"Overton Found Guilty of Wife's Cyanide Murder" 2108:Nuts and Seeds in Health and Disease Prevention 962:, is used to bind cyanide to form the harmless 895:Cyanide binds avidly to methemoglobin, forming 4462:"Chronology of Aum Shinrikyo's CBW Activities" 4451:(Spring Science+Business Media, 2002), p. 164. 4005:"Preliminary results autopsy Slobodan Praljak" 3640:. University of California Press. p. 24. 2926: 2924: 2868: 2719: 1743:, who became quickly known as "Am Cyanide" in 587:a3-CuB binuclear center of COX (and thus is a 5134: 4766: 4579:. Oxford; New York: Oxford University Press. 4414: 2141: 1097:is not a cure in its own right. However, the 1075:-2,5-dicarboxylic acid disodium salt), which 1010:otherwise, nitrite/thiosulfate is preferred. 755:is typically measured to determine exposure. 673:concentration becomes too low for the normal 109:, low blood pressure, loss of consciousness, 4400:: CS1 maint: multiple names: authors list ( 3744: 3633: 2845: 2843: 2586:: CS1 maint: multiple names: authors list ( 540:(also known as tapioca, yuca or manioc) and 3715: 3530:"Novel, orally effective cyanide antidotes" 2921: 2686: 1415:(1946) all died by suicide by ingesting it. 235:Toxic cyanide-containing compounds include 4773: 4759: 4431:Centers for Disease Control and Prevention 4087: 2720:David M. Cline, et al., eds. (2012). 2288: 2214: 2212: 2137: 2135: 1590:(1916; attempted, later killed by gunshot) 1052:A different cyanide-metabolizing pathway, 782:International Programme on Chemical Safety 595:, which not only blocks the mitochondrial 570:oxidase (COX, a.k.a. Complex IV) inhibitor 4571: 4116: 3667: 3553: 3504: 3162: 3072: 3036:Parikh S, Goldstein A, Koenig MK (2015). 2981: 2935:(4th ed.). New York: W. H. Freeman. 2930: 2892: 2854:(5th ed.). New York: W. H. Freeman. 2840: 2772: 2762: 2704: 2689:"The fire toxicity of polyurethane foams" 2571: 2245: 2243: 2241: 2063: 2061: 2025: 2023: 2021: 2019: 2017: 2015: 2013: 2011: 1983: 1961: 1959: 1957: 1955: 1953: 1951: 1949: 1947: 1945: 1943: 1428:illegal at the time in the United Kingdom 1206:Research of hydrogen cyanide by chemists 46:Cyanide toxicity, hydrocyanic acid poison 4369: 2105: 2070:Dorland's Illustrated Medical Dictionary 1941: 1939: 1937: 1935: 1933: 1931: 1929: 1927: 1925: 1923: 1538: 1311:) dropped into a compartment containing 1186: 495:or other polymer products that required 416: 4484: 4338: 3926:. Frontline Books–Skyhorse Publishing. 3255: 3232: 2850:Berg JM, Tymoczko JL, Stryer L (2002). 2334:World Review of Nutrition and Dietetics 2209: 2132: 2099: 1752: 1609:, Guyana, was the site of a large mass 1299:Hydrogen cyanide gas has been used for 1083:, is being evaluated in animal models. 881:some of the hemoglobin's iron from the 807:kit first uses a small inhaled dose of 513:Many seeds or kernels such as those of 14: 5740: 4441: 4252: 4075:from the original on 27 September 2021 4045:from the original on 27 September 2021 3894:from the original on 20 February 2009. 3305:from the original on 8 September 2017. 3245:from the original on 29 December 2008. 2751:European Food Safety Authority Journal 2722:Tintinalli's emergency medicine manual 2379:Ecotoxicology and Environmental Safety 2238: 2184: 2058: 2008: 1972:European Journal of Emergency Medicine 1887: 1475:, including United States Congressman 889:state, converting the hemoglobin into 548:As a potential harm-reduction factor, 4754: 4615: 4593: 4320:from the original on 13 February 2017 4283: 4265:from the original on 27 December 2019 4234:from the original on 27 December 2019 3916: 3835:"Gas chamber | execution device" 3821: 3809: 3793: 3781: 3769: 3703: 3691: 3679: 3627: 3615:from the original on 14 February 2013 3355:from the original on 22 January 2012. 3219:from the original on 20 October 2009. 2949: 2321:from the original on 4 February 2009. 2261:from the original on 14 November 2016 2226:from the original on 21 December 2016 2029: 1920: 1908:from the original on 8 September 2017 607:pathway it facilitates, owing to the 324: 5704: 4129:from the original on 2 February 2015 3981:. Alabama Local News. Archived from 3603:Haynes and Prada (2 February 2013). 3284: 3017:from the original on 8 November 2019 2933:Lehninger Principles of Biochemistry 2533:10.1016/j.theriogenology.2003.12.023 1854: 1379:Cyanide, in the form of pure liquid 1234:installed in extermination camps at 1054:3-mercaptopyruvate sulfurtransferase 907:may need to be treated in turn with 464:It is generated on site by reacting 5716: 4628:Anatomy of the Auschwitz Death Camp 4351:from the original on 8 October 2019 4180:"Was It Murder or Suicide: A Forum" 4065:"InfoLeg - InformaciĂłn Legislativa" 3904:"Operation Gunnerside" in the book 3584:from the original on 28 August 2021 3116:from the original on 18 April 2007. 3004: 2331: 2197:from the original on 18 August 2017 1613:, in which over 900 members of the 803:The United States standard cyanide 583:Specifically, cyanide binds to the 433:, skin absorption of prussic acid, 384: 293:and giving the person 100% oxygen. 152:, eating seeds such as from almonds 24: 4190:from the original on 26 March 2016 3967:from the original on 27 July 2012. 3726:from the original on 15 March 2022 3580:(in Portuguese). 27 January 2013. 3415:10.1002/j.1552-4604.1992.tb03849.x 2974:10.1002/j.1460-2075.1994.tb06541.x 2646:Veterinary Research Communications 2463:from the original on 22 March 2020 2292:Essentials of Medical Biochemistry 2116:10.1016/b978-0-12-375688-6.10014-3 1315:, directly below the chair in the 1270:(SS) by the distributors Heli and 763: 25: 5769: 4382:from the original on 10 July 2018 4370:Parascandola Kerry Burke, Rocco. 4154:. Simon & Schuster. pp.  3841:from the original on 28 June 2015 3193:from the original on 5 March 2016 2573:10.1016/j.smallrumres.2009.09.029 2317:. Health Canada. 6 October 2008. 1689:response following heart failure. 1146:RepĂşblica Cromañón nightclub fire 329: 5715: 5703: 5692: 5691: 4117:Kenworthy T (13 December 1999). 3868:from the original on 5 July 2015 3318:Journal of Occupational Medicine 3272:10.1001/jama.1933.02740050053028 3187:"New Antidote for Cyanide Found" 2087:from the original on 14 May 2020 1705:at a cafe in a shopping mall in 1443:Liberation Tigers of Tamil Eelam 1418:It is speculated that, in 1954, 51: 4512: 4478: 4454: 4423: 4408: 4363: 4332: 4300: 4277: 4246: 4216: 4202: 4172: 4148:Dugoni R, Hilldorfer J (2004). 4110: 4057: 4027: 3997: 3971: 3949: 3940: 3910: 3898: 3880: 3854: 3827: 3738: 3709: 3596: 3570: 3521: 3472: 3437: 3394: 3359: 3336: 3309: 3278: 3249: 3215:. Health and Safety Executive. 3205: 3179: 3137: 3120: 3098: 3089: 2998: 2909:from the original on 5 May 2019 2738: 2713: 2680: 2637: 2594: 2547: 2512: 2475: 2370: 2325: 2307: 2282: 2273: 1861: 1772:station, consisting of bags of 1569:Environmental Protection Agency 1515:, died after ingesting cyanide. 1454:Aleksandr Dmitrievich Ogorodnik 1182: 1117: 421:Removal of cyanide poison from 96:, shortness of breath, vomiting 3368:Comparative Clinical Pathology 3233:Leybell I (12 November 2019). 2178: 2110:. Elsevier. pp. 129–136. 1881: 1741:Sararath "Am" Rangsiwutthiporn 1486:On 6 June 1985, serial killer 278:, low blood pressure, or high 13: 1: 4618:"Gas Chambers and Crematoria" 4041:(in Spanish). 20 April 2018. 3722:. Penguin. pp. 132–133. 2623:10.1016/S0300-483X(02)00041-0 2498:10.1016/S0278-6915(02)00151-5 2429:Journal of Applied Toxicology 1849: 1810:is the final compound in the 833:intra-muscular (IM) injection 611:between those two processes. 305:and is generally first-line. 301:) appears to be useful as an 228:, loss of consciousness, and 4339:Dhillon A (7 October 2019). 3497:10.1016/j.toxlet.2007.10.001 2826:10.1016/0300-483X(79)90068-4 2687:McKenna ST, Hull TR (2016). 2485:Food and Chemical Toxicology 2279:Longerich 2010, pp. 281–282. 2156:10.3109/15563650.2012.742197 1985:10.1097/mej.0b013e328357170b 1891:Handbook of Autopsy Practice 1874: 1250:, a corporation co-owned by 1165:a fire at the Kiss nightclub 758: 657: 559: 476:(e.g., in a modern American 239:gas and a number of cyanide 7: 3796:, pp. 294–297, chpt. " 3170:Toxicity, Cyanide~treatment 3051:(9). Elsevier BV: 689–701. 2289:Bhagavan NV, Ha CE (2015). 1817: 1802: 1557:spill at Baia Mare, Romania 1526:, after being convicted of 1458:Central Intelligence Agency 1364:died by suicide by cyanide. 1071:sodium (2, 5-dihydroxy-1,4- 775: 338:is inhaled, it can cause a 10: 5774: 5444:Arthropod bites and stings 5063:Nitrogen dioxide poisoning 4565: 4485:Suskind R (19 June 2006). 3128:Toxicity, Cyanide~overview 2931:Nelson DL, Cox MM (2004). 2185:Hevesi D (26 March 1993). 1326: 1322: 1134: 815:, followed by intravenous 811:, followed by intravenous 5687: 5659: 5655: 5619: 5563: 5511: 5434: 5350: 5286: 5279: 5238: 5211: 5203:Tricyclic antidepressants 5143: 5125: 5071: 5043: 5013: 5004: 4967: 4949: 4929: 4886: 4838: 4829: 4820: 4802: 4724: 4654: 4529:10.1515/9783110527872-020 4288:. Pittsburgh Post-Gazette 4253:Gorner J (25 July 2017). 3380:10.1007/s00580-006-0647-x 3007:"Cyanide Toxicity Workup" 2706:10.1186/s40038-016-0012-3 2658:10.1007/s11259-006-3361-x 1575: 1452:On 22 June 1977, Moscow, 1403:(1945), and Nazi leaders 1360:In 1937, polymer chemist 589:non-competitive inhibitor 578:oxidative phosphorylation 412: 200:. Early symptoms include 169: 156: 135: 124: 116: 83: 67: 59: 50: 42: 37: 4069:servicios.infoleg.gob.ar 3888:"Gas Chamber Executions" 2764:10.2903/j.efsa.2019.5662 1505:; he died minutes after. 1426:relationship, which was 1195:canisters, found by the 1139: 844:Health Service Executive 597:electron transport chain 162:Based on symptoms, high 27:Broad-spectrum poisoning 5642:List of types of poison 5198:Serotonergic substances 3745:Christianson S (2010). 3634:Christianson S (2010). 2560:Small Ruminant Research 1629:Chicago Tylenol murders 626:), works by converting 618:for cyanide poisoning, 92:: headache, dizziness, 4930:Other non-toxic metals 4624:, Berenbaum M (eds.). 4415:Rebecca Ratcliffe NS. 4099:9 January 2009 at the 3923:With Hitler to the End 3458:10.1002/jbt.2570040106 3149:www.accessdata.fda.gov 2881:Toxicological Sciences 2399:10.1006/eesa.2002.2189 2220:"Sodium Nitroprusside" 1703:Vietnamese iced coffee 1203: 426: 276:level of consciousness 78:critical care medicine 5310:Ichthyoallyeinotoxism 4435:"Facts About Cyanide" 3798:Degesch and Zyklon B. 2894:10.1093/toxsci/kfm254 2038:(1): 72–81, quiz 82. 1539:Mining and industrial 1518:On 29 November 2017, 1463:On 18 November 1978, 1262:. It was sold to the 1190: 981:4-Dimethylaminophenol 976:4-Dimethylaminophenol 850:, potential to cause 483:Fumes arise during a 420: 289:. Treatment involves 4474:on 26 November 2011. 3719:Auschwitz: A History 3716:Steinbacher (2005). 3285:Dart R, ed. (2004). 3057:10.1038/gim.2014.177 3045:Genetics in Medicine 2693:Fire Science Reviews 1824:Anaerobic glycolysis 1796:New York City Subway 1753:Warfare or terrorism 1643:Ronald Clark O'Bryan 1635:Timothy Marc O'Bryan 1369:Operation Gunnerside 1208:Carl Wilhelm Scheele 1163:On 27 January 2013, 770:full decontamination 667:anaerobic glycolysis 601:mitochondrial matrix 564:Cyanide is a potent 499:in their production. 435:intravenous infusion 313:and it was used for 265:cellular respiration 257:sodium nitroprusside 5680:foodborne illnesses 5637:Lists of poisonings 5320:Shellfish poisoning 5028:Aluminium phosphide 4316:. 7 November 2014. 4123:The Washington Post 4009:Openbaar Ministerie 3772:, pp. 288–289. 3670:, pp. 281–282. 3446:J. Biochem. Toxicol 2818:1979Toxgy..12..221C 2615:2002Toxgy.174...87S 2391:2002EcoES..53...37S 2257:. 14 January 2015. 2144:Clinical Toxicology 2032:Critical Care Nurse 1522:died from drinking 1224:extermination camps 1199:in January 1945 at 675:aerobic respiration 443:hypertensive crisis 307:Sodium thiosulphate 214:shortness of breath 5632:EPA list of hazard 5414:Alpha-Bungarotoxin 5158:Anticholinesterase 4725:External resources 4500:on 10 January 2007 4151:The Cyanide Canary 4107:, 15 February 2000 4094:"Death of a river" 4015:on 3 December 2017 3682:, pp. 2, 272. 3351:(in Spanish) (7). 3288:Medical Toxicology 3235:"Cyanide Toxicity" 2191:The New York Times 2044:10.4037/ccn2011799 1888:Waters BL (2010). 1834:List of poisonings 1735:Brooklyn, New York 1693:Autumn Marie Klein 1677:with artifacts of 1483:at Jones' command. 1329:Suicide prevention 1301:judicial execution 1260:Th. Goldschmidt AG 1236:Auschwitz-Birkenau 1204: 1171:, in the south of 1041:3-Mercaptopyruvate 924:sodium thiosulfate 817:sodium thiosulfate 716:", an artifact of 710:Lipid peroxidation 609:close relationship 574:histotoxic hypoxia 427: 325:Signs and symptoms 226:low blood pressure 5735: 5734: 5731: 5730: 5615: 5614: 5597:Poisonous animals 5275: 5274: 5240:Vitamin poisoning 5234: 5233: 5121: 5120: 5000: 4999: 4945: 4944: 4748: 4747: 4643:978-0-253-32684-3 4608:978-0-521-78227-2 4586:978-0-19-280436-5 4538:978-3-11-052691-2 4228:Los Angeles Times 4165:978-0-7432-4652-1 3933:978-1-60239-804-7 3756:978-0-520-25562-3 3647:978-0-520-25562-3 3546:10.1021/jm7011497 3540:(26): 6462–6464. 3298:978-0-7817-2845-4 3189:. February 2013. 2968:(11): 2516–2525. 2942:978-0-7167-6265-2 2731:978-0-07-178184-8 2492:(11): 1693–1698. 2355:978-3-8055-0662-5 2346:10.1159/000387578 2295:(Second ed.) 2125:978-0-12-375688-6 2080:978-1-4557-0985-4 1901:978-1-59745-127-7 1855:Explanatory notes 1659:Richard Kuklinski 1619:potassium cyanide 1595:Goebbels children 1524:potassium cyanide 1493:On 28 June 2012, 1437:(or Eelam Tamil) 1407:(1945), possibly 1362:Wallace Carothers 1305:potassium cyanide 1113: 1112: 966:form of vitamin B 922:The evidence for 905:methemoglobinemia 897:cyanmethemoglobin 800:, respectively). 737:mass spectrometry 552:, in the form of 466:potassium cyanide 375:oxygen saturation 255:, the medication 190:Cyanide poisoning 187: 186: 158:Diagnostic method 32:Medical condition 16:(Redirected from 5765: 5719: 5718: 5707: 5706: 5695: 5694: 5668:, which is rare. 5657: 5656: 5592:Venomous animals 5284: 5283: 5141: 5140: 5132: 5131: 5033:Organophosphates 5011: 5010: 4888:Dietary minerals 4836: 4835: 4827: 4826: 4775: 4768: 4761: 4752: 4751: 4652: 4651: 4647: 4631: 4616:Piper F (1994). 4612: 4590: 4559: 4558: 4516: 4510: 4509: 4507: 4505: 4496:. Archived from 4482: 4476: 4475: 4473: 4466: 4458: 4452: 4445: 4439: 4438: 4433:(4 April 2018). 4427: 4421: 4420: 4412: 4406: 4405: 4399: 4391: 4389: 4387: 4367: 4361: 4360: 4358: 4356: 4336: 4330: 4329: 4327: 4325: 4304: 4298: 4297: 4295: 4293: 4281: 4275: 4274: 4272: 4270: 4250: 4244: 4243: 4241: 4239: 4220: 4214: 4213: 4206: 4200: 4199: 4197: 4195: 4176: 4170: 4169: 4145: 4139: 4138: 4136: 4134: 4114: 4108: 4091: 4085: 4084: 4082: 4080: 4061: 4055: 4054: 4052: 4050: 4031: 4025: 4024: 4022: 4020: 4011:. Archived from 4001: 3995: 3994: 3992: 3990: 3975: 3969: 3968: 3953: 3947: 3944: 3938: 3937: 3914: 3908: 3902: 3896: 3895: 3884: 3878: 3877: 3875: 3873: 3858: 3852: 3851:second paragraph 3850: 3848: 3846: 3831: 3825: 3819: 3813: 3807: 3801: 3791: 3785: 3779: 3773: 3767: 3761: 3760: 3742: 3736: 3735: 3733: 3731: 3713: 3707: 3701: 3695: 3689: 3683: 3677: 3671: 3665: 3659: 3658: 3656: 3654: 3631: 3625: 3624: 3622: 3620: 3600: 3594: 3593: 3591: 3589: 3574: 3568: 3567: 3557: 3525: 3519: 3518: 3508: 3491:(1–3): 111–117. 3476: 3470: 3469: 3441: 3435: 3434: 3403:J Clin Pharmacol 3398: 3392: 3391: 3363: 3357: 3356: 3340: 3334: 3333: 3313: 3307: 3306: 3282: 3276: 3275: 3253: 3247: 3246: 3230: 3221: 3220: 3209: 3203: 3202: 3200: 3198: 3183: 3177: 3166: 3160: 3159: 3157: 3155: 3141: 3135: 3124: 3118: 3117: 3102: 3096: 3093: 3087: 3086: 3076: 3042: 3033: 3027: 3026: 3024: 3022: 3002: 2996: 2995: 2985: 2962:The EMBO Journal 2953: 2947: 2946: 2928: 2919: 2918: 2916: 2914: 2896: 2872: 2866: 2865: 2847: 2838: 2837: 2801: 2795: 2794: 2776: 2766: 2742: 2736: 2735: 2717: 2711: 2710: 2708: 2684: 2678: 2677: 2641: 2635: 2634: 2598: 2592: 2591: 2585: 2577: 2575: 2551: 2545: 2544: 2516: 2510: 2509: 2479: 2473: 2472: 2470: 2468: 2441:10.1002/jat.1286 2420: 2411: 2410: 2374: 2368: 2367: 2329: 2323: 2322: 2311: 2305: 2304: 2302: 2300: 2286: 2280: 2277: 2271: 2270: 2268: 2266: 2247: 2236: 2235: 2233: 2231: 2216: 2207: 2206: 2204: 2202: 2182: 2176: 2175: 2139: 2130: 2129: 2103: 2097: 2096: 2094: 2092: 2065: 2056: 2055: 2027: 2006: 2005: 1987: 1963: 1918: 1917: 1915: 1913: 1885: 1868: 1865: 1760:Halabja massacre 1588:Grigori Rasputin 1520:Slobodan Praljak 1503:Phoenix, Arizona 1435:Sri Lankan Tamil 1405:Heinrich Himmler 1128: 1121: 1029:Grigori Rasputin 1002:dicobalt edetate 993:Dicobalt edetate 945:Hydroxocobalamin 940:Hydroxocobalamin 861: 860: 821:Hydroxocobalamin 798:sodium carbonate 554:hydroxocobalamin 536:Foods including 385:Chronic exposure 336:hydrogen cyanide 295:Hydroxocobalamin 237:hydrogen cyanide 182:hydroxocobalamin 55: 35: 34: 21: 18:Cyanide toxicity 5773: 5772: 5768: 5767: 5766: 5764: 5763: 5762: 5738: 5737: 5736: 5727: 5683: 5669: 5651: 5611: 5559: 5507: 5430: 5346: 5271: 5266: 5230: 5207: 5173:Benzodiazepines 5117: 5103:Carbon monoxide 5091:Ethylene glycol 5067: 5039: 4996: 4963: 4941: 4925: 4882: 4816: 4798: 4779: 4749: 4744: 4743: 4720: 4719: 4663: 4644: 4609: 4587: 4568: 4563: 4562: 4539: 4517: 4513: 4503: 4501: 4483: 4479: 4471: 4464: 4460: 4459: 4455: 4446: 4442: 4428: 4424: 4413: 4409: 4393: 4392: 4385: 4383: 4376:nydailynews.com 4368: 4364: 4354: 4352: 4337: 4333: 4323: 4321: 4306: 4305: 4301: 4291: 4289: 4282: 4278: 4268: 4266: 4259:Chicago Tribune 4251: 4247: 4237: 4235: 4221: 4217: 4208: 4207: 4203: 4193: 4191: 4178: 4177: 4173: 4166: 4146: 4142: 4132: 4130: 4115: 4111: 4101:Wayback Machine 4092: 4088: 4078: 4076: 4063: 4062: 4058: 4048: 4046: 4033: 4032: 4028: 4018: 4016: 4003: 4002: 3998: 3988: 3986: 3985:on 6 April 2017 3977: 3976: 3972: 3955: 3954: 3950: 3945: 3941: 3934: 3915: 3911: 3903: 3899: 3886: 3885: 3881: 3871: 3869: 3860: 3859: 3855: 3844: 3842: 3833: 3832: 3828: 3820: 3816: 3808: 3804: 3792: 3788: 3780: 3776: 3768: 3764: 3757: 3743: 3739: 3729: 3727: 3714: 3710: 3702: 3698: 3690: 3686: 3678: 3674: 3666: 3662: 3652: 3650: 3648: 3632: 3628: 3618: 3616: 3601: 3597: 3587: 3585: 3576: 3575: 3571: 3526: 3522: 3477: 3473: 3442: 3438: 3399: 3395: 3364: 3360: 3341: 3337: 3314: 3310: 3299: 3283: 3279: 3254: 3250: 3231: 3224: 3211: 3210: 3206: 3196: 3194: 3185: 3184: 3180: 3167: 3163: 3153: 3151: 3143: 3142: 3138: 3125: 3121: 3104: 3103: 3099: 3094: 3090: 3040: 3034: 3030: 3020: 3018: 3003: 2999: 2954: 2950: 2943: 2929: 2922: 2912: 2910: 2873: 2869: 2862: 2848: 2841: 2802: 2798: 2743: 2739: 2732: 2718: 2714: 2685: 2681: 2642: 2638: 2599: 2595: 2579: 2578: 2552: 2548: 2517: 2513: 2480: 2476: 2466: 2464: 2421: 2414: 2375: 2371: 2356: 2330: 2326: 2313: 2312: 2308: 2298: 2296: 2287: 2283: 2278: 2274: 2264: 2262: 2249: 2248: 2239: 2229: 2227: 2218: 2217: 2210: 2200: 2198: 2183: 2179: 2150:(10): 875–885. 2140: 2133: 2126: 2104: 2100: 2090: 2088: 2081: 2067: 2066: 2059: 2028: 2009: 1964: 1921: 1911: 1909: 1902: 1886: 1882: 1877: 1872: 1871: 1866: 1862: 1857: 1852: 1844:Murburn concept 1829:Lactic acidosis 1820: 1805: 1755: 1675:false positives 1578: 1541: 1433:Members of the 1371:to destroy the 1351:Horacio Quiroga 1344:Whitaker Wright 1332: 1325: 1185: 1167:in the city of 1158:carbon monoxide 1142: 1137: 1132: 1131: 1122: 1118: 1025: 969: 961: 956: 827:antidote kits. 790:ferrous sulfate 778: 766: 764:Decontamination 761: 706:false positives 665:is produced by 660: 653: 632:ferrihemoglobin 628:ferrohemoglobin 594: 562: 415: 387: 368:pulmonary edema 332: 327: 300: 291:supportive care 263:interfere with 249:metal polishing 222:slow heart rate 210:fast heart rate 180:(100% oxygen), 178:supportive care 174:Decontamination 146:metal polishing 107:slow heart rate 97: 94:fast heart rate 33: 28: 23: 22: 15: 12: 11: 5: 5771: 5761: 5760: 5755: 5750: 5733: 5732: 5729: 5728: 5726: 5725: 5713: 5701: 5688: 5685: 5684: 5653: 5652: 5650: 5649: 5644: 5639: 5634: 5629: 5623: 5621: 5617: 5616: 5613: 5612: 5610: 5609: 5607:Mycotoxicology 5604: 5599: 5594: 5589: 5584: 5583: 5582: 5567: 5565: 5564:Related topics 5561: 5560: 5558: 5557: 5552: 5547: 5542: 5537: 5532: 5527: 5521: 5519: 5509: 5508: 5506: 5505: 5503:Tick paralysis 5500: 5499: 5498: 5493: 5479: 5478: 5477: 5470:Scorpion venom 5467: 5466: 5465: 5460: 5446: 5440: 5438: 5432: 5431: 5429: 5428: 5427: 5426: 5421: 5416: 5402: 5397: 5396: 5395: 5385: 5384: 5383: 5378: 5373: 5368: 5357: 5355: 5348: 5347: 5345: 5344: 5343: 5342: 5337: 5332: 5327: 5317: 5312: 5307: 5302: 5296: 5294: 5281: 5277: 5276: 5273: 5272: 5270: 5269: 5264: 5260: 5255: 5250: 5244: 5242: 5236: 5235: 5232: 5231: 5229: 5228: 5223: 5217: 5215: 5213:Cardiovascular 5209: 5208: 5206: 5205: 5200: 5195: 5190: 5185: 5180: 5175: 5170: 5165: 5160: 5155: 5149: 5147: 5138: 5136:Drug overdoses 5129: 5127:Pharmaceutical 5123: 5122: 5119: 5118: 5116: 5115: 5110: 5105: 5100: 5099: 5098: 5093: 5088: 5075: 5073: 5069: 5068: 5066: 5065: 5060: 5055: 5049: 5047: 5041: 5040: 5038: 5037: 5036: 5035: 5030: 5019: 5017: 5008: 5002: 5001: 4998: 4997: 4995: 4994: 4989: 4984: 4979: 4973: 4971: 4965: 4964: 4962: 4961: 4955: 4953: 4947: 4946: 4943: 4942: 4940: 4939: 4933: 4931: 4927: 4926: 4924: 4923: 4918: 4913: 4908: 4903: 4898: 4892: 4890: 4884: 4883: 4881: 4880: 4875: 4870: 4865: 4860: 4855: 4850: 4844: 4842: 4833: 4824: 4818: 4817: 4815: 4814: 4809: 4803: 4800: 4799: 4797: 4796: 4791: 4786: 4778: 4777: 4770: 4763: 4755: 4746: 4745: 4742: 4741: 4729: 4728: 4726: 4722: 4721: 4718: 4717: 4706: 4695: 4680: 4664: 4659: 4658: 4656: 4655:Classification 4649: 4648: 4642: 4613: 4607: 4591: 4585: 4567: 4564: 4561: 4560: 4537: 4511: 4477: 4453: 4440: 4422: 4407: 4362: 4331: 4299: 4276: 4245: 4230:. 9 May 1995. 4215: 4201: 4171: 4164: 4140: 4109: 4086: 4056: 4026: 3996: 3970: 3948: 3939: 3932: 3909: 3897: 3879: 3853: 3826: 3824:, p. 284. 3814: 3812:, p. 283. 3802: 3786: 3784:, p. 296. 3774: 3762: 3755: 3737: 3708: 3706:, p. 272. 3696: 3694:, p. 161. 3684: 3672: 3668:Longerich 2010 3660: 3646: 3626: 3595: 3569: 3520: 3471: 3436: 3409:(4): 368–375. 3393: 3358: 3335: 3324:(6): 414–416. 3308: 3297: 3277: 3248: 3222: 3204: 3178: 3161: 3136: 3119: 3097: 3088: 3028: 2997: 2948: 2941: 2920: 2887:(1): 101–111. 2867: 2860: 2839: 2812:(3): 221–234. 2796: 2737: 2730: 2712: 2679: 2636: 2593: 2566:(1–3): 76–80. 2546: 2527:(6): 1012–26. 2521:Theriogenology 2511: 2474: 2412: 2369: 2354: 2324: 2306: 2281: 2272: 2237: 2208: 2177: 2131: 2124: 2098: 2079: 2057: 2007: 1919: 1900: 1879: 1878: 1876: 1873: 1870: 1869: 1859: 1858: 1856: 1853: 1851: 1848: 1847: 1846: 1841: 1836: 1831: 1826: 1819: 1816: 1804: 1801: 1800: 1799: 1788: 1774:sodium cyanide 1763: 1754: 1751: 1750: 1749: 1738: 1728: 1710: 1696: 1690: 1683:kidney failure 1668: 1662: 1656: 1646: 1641:. His father, 1632: 1626: 1615:Peoples Temple 1611:murder–suicide 1604: 1601:Stepan Bandera 1598: 1591: 1585: 1577: 1574: 1573: 1572: 1564: 1553: 1540: 1537: 1536: 1535: 1516: 1506: 1491: 1484: 1461: 1450: 1431: 1416: 1413:Hermann Göring 1409:Martin Bormann 1377: 1365: 1358: 1347: 1324: 1321: 1309:sodium cyanide 1212:Claude Bernard 1184: 1181: 1141: 1138: 1136: 1133: 1130: 1129: 1124:Methylene blue 1115: 1114: 1111: 1110: 1101:is capable of 1095:Oxygen therapy 1092: 1090:Oxygen therapy 1086: 1085: 1044: 1037: 1036: 1018: 1012: 1011: 995: 989: 988: 978: 972: 971: 967: 964:cyanocobalamin 959: 954: 942: 936: 935: 920: 914: 913: 909:methylene blue 875: 869: 868: 865: 852:iron poisoning 829:Sulfanegen TEA 813:sodium nitrite 796:, and aqueous 777: 774: 765: 762: 760: 757: 712:resulting in " 659: 656: 651: 592: 561: 558: 546: 545: 534: 511: 501: 500: 481: 470:sodium cyanide 462: 414: 411: 403:hypothyroidism 386: 383: 352:cardiac arrest 331: 330:Acute exposure 328: 326: 323: 298: 287:decontaminated 230:cardiac arrest 185: 184: 171: 167: 166: 160: 154: 153: 139: 133: 132: 126: 122: 121: 118: 114: 113: 111:cardiac arrest 87: 81: 80: 71: 65: 64: 57: 56: 48: 47: 44: 40: 39: 38:Cyanide poison 31: 26: 9: 6: 4: 3: 2: 5770: 5759: 5756: 5754: 5751: 5749: 5746: 5745: 5743: 5724: 5723: 5714: 5712: 5711: 5702: 5700: 5699: 5690: 5689: 5686: 5681: 5677: 5673: 5667: 5663: 5658: 5654: 5648: 5645: 5643: 5640: 5638: 5635: 5633: 5630: 5628: 5625: 5624: 5622: 5620:Miscellaneous 5618: 5608: 5605: 5603: 5602:Deadly fungus 5600: 5598: 5595: 5593: 5590: 5588: 5585: 5581: 5578: 5577: 5576: 5572: 5569: 5568: 5566: 5562: 5556: 5553: 5551: 5548: 5546: 5543: 5541: 5538: 5536: 5533: 5531: 5528: 5526: 5523: 5522: 5520: 5518: 5514: 5510: 5504: 5501: 5497: 5494: 5492: 5488: 5485: 5484: 5483: 5480: 5476: 5475:Charybdotoxin 5473: 5472: 5471: 5468: 5464: 5461: 5459: 5456: 5455: 5454: 5450: 5447: 5445: 5442: 5441: 5439: 5437: 5433: 5425: 5422: 5420: 5417: 5415: 5412: 5411: 5410: 5406: 5403: 5401: 5398: 5394: 5391: 5390: 5389: 5386: 5382: 5379: 5377: 5374: 5372: 5369: 5367: 5366:Batrachotoxin 5364: 5363: 5362: 5359: 5358: 5356: 5354: 5349: 5341: 5338: 5336: 5333: 5331: 5328: 5326: 5323: 5322: 5321: 5318: 5316: 5313: 5311: 5308: 5306: 5303: 5301: 5298: 5297: 5295: 5293: 5289: 5285: 5282: 5278: 5268: 5263:Megavitamin-B 5261: 5259: 5256: 5254: 5251: 5249: 5246: 5245: 5243: 5241: 5237: 5227: 5224: 5222: 5219: 5218: 5216: 5214: 5210: 5204: 5201: 5199: 5196: 5194: 5191: 5189: 5186: 5184: 5181: 5179: 5176: 5174: 5171: 5169: 5166: 5164: 5161: 5159: 5156: 5154: 5151: 5150: 5148: 5146: 5142: 5139: 5137: 5133: 5130: 5128: 5124: 5114: 5111: 5109: 5106: 5104: 5101: 5097: 5094: 5092: 5089: 5087: 5084: 5083: 5082: 5081: 5077: 5076: 5074: 5070: 5064: 5061: 5059: 5056: 5054: 5051: 5050: 5048: 5046: 5042: 5034: 5031: 5029: 5026: 5025: 5024: 5021: 5020: 5018: 5016: 5012: 5009: 5007: 5003: 4993: 4990: 4988: 4985: 4983: 4980: 4978: 4977:Sulfuric acid 4975: 4974: 4972: 4970: 4966: 4960: 4957: 4956: 4954: 4952: 4948: 4938: 4935: 4934: 4932: 4928: 4922: 4919: 4917: 4914: 4912: 4909: 4907: 4904: 4902: 4899: 4897: 4894: 4893: 4891: 4889: 4885: 4879: 4876: 4874: 4871: 4869: 4866: 4864: 4861: 4859: 4856: 4854: 4851: 4849: 4846: 4845: 4843: 4841: 4837: 4834: 4832: 4828: 4825: 4823: 4819: 4813: 4810: 4808: 4805: 4804: 4801: 4795: 4792: 4790: 4787: 4785: 4782: 4781: 4776: 4771: 4769: 4764: 4762: 4757: 4756: 4753: 4740: 4736: 4735: 4731: 4730: 4727: 4723: 4716: 4712: 4711: 4707: 4705: 4701: 4700: 4696: 4694: 4690: 4689: 4685: 4681: 4679: 4675: 4674: 4670: 4666: 4665: 4662: 4657: 4653: 4645: 4639: 4635: 4630: 4629: 4623: 4619: 4614: 4610: 4604: 4600: 4596: 4592: 4588: 4582: 4578: 4574: 4570: 4569: 4556: 4552: 4548: 4544: 4540: 4534: 4530: 4526: 4522: 4515: 4499: 4495: 4493: 4488: 4481: 4470: 4463: 4457: 4450: 4444: 4436: 4432: 4426: 4418: 4411: 4403: 4397: 4381: 4377: 4373: 4366: 4350: 4346: 4342: 4335: 4319: 4315: 4314: 4309: 4303: 4287: 4284:Reed Ward P. 4280: 4264: 4260: 4256: 4249: 4233: 4229: 4225: 4219: 4211: 4205: 4189: 4185: 4181: 4175: 4167: 4161: 4157: 4153: 4152: 4144: 4128: 4124: 4120: 4113: 4106: 4102: 4098: 4095: 4090: 4074: 4070: 4066: 4060: 4044: 4040: 4036: 4030: 4014: 4010: 4006: 4000: 3984: 3980: 3974: 3966: 3962: 3958: 3952: 3943: 3935: 3929: 3925: 3924: 3919: 3913: 3907: 3901: 3893: 3890:. About.com. 3889: 3883: 3867: 3863: 3857: 3840: 3836: 3830: 3823: 3818: 3811: 3806: 3799: 3795: 3790: 3783: 3778: 3771: 3766: 3758: 3752: 3748: 3741: 3725: 3721: 3720: 3712: 3705: 3700: 3693: 3688: 3681: 3676: 3669: 3664: 3649: 3643: 3639: 3638: 3630: 3614: 3610: 3606: 3599: 3583: 3579: 3573: 3565: 3561: 3556: 3551: 3547: 3543: 3539: 3535: 3531: 3524: 3516: 3512: 3507: 3502: 3498: 3494: 3490: 3486: 3485:Toxicol. Lett 3482: 3475: 3467: 3463: 3459: 3455: 3451: 3447: 3440: 3432: 3428: 3424: 3420: 3416: 3412: 3408: 3404: 3397: 3389: 3385: 3381: 3377: 3373: 3369: 3362: 3354: 3350: 3346: 3339: 3331: 3327: 3323: 3319: 3312: 3304: 3300: 3294: 3290: 3289: 3281: 3273: 3269: 3265: 3261: 3260: 3252: 3244: 3240: 3236: 3229: 3227: 3218: 3214: 3208: 3192: 3188: 3182: 3176: 3172: 3171: 3165: 3150: 3146: 3140: 3134: 3130: 3129: 3123: 3115: 3111: 3107: 3101: 3092: 3084: 3080: 3075: 3070: 3066: 3062: 3058: 3054: 3050: 3046: 3039: 3032: 3016: 3012: 3008: 3001: 2993: 2989: 2984: 2979: 2975: 2971: 2967: 2963: 2959: 2952: 2944: 2938: 2934: 2927: 2925: 2908: 2904: 2900: 2895: 2890: 2886: 2882: 2878: 2871: 2863: 2861:0-7167-3051-0 2857: 2853: 2846: 2844: 2835: 2831: 2827: 2823: 2819: 2815: 2811: 2807: 2800: 2792: 2788: 2784: 2780: 2775: 2770: 2765: 2760: 2757:(4). e05662. 2756: 2752: 2748: 2741: 2733: 2727: 2723: 2716: 2707: 2702: 2698: 2694: 2690: 2683: 2675: 2671: 2667: 2663: 2659: 2655: 2652:(1): 93–104. 2651: 2647: 2640: 2632: 2628: 2624: 2620: 2616: 2612: 2608: 2604: 2597: 2589: 2583: 2574: 2569: 2565: 2561: 2557: 2550: 2542: 2538: 2534: 2530: 2526: 2522: 2515: 2507: 2503: 2499: 2495: 2491: 2487: 2486: 2478: 2462: 2458: 2454: 2450: 2446: 2442: 2438: 2435:(3): 356–63. 2434: 2430: 2426: 2419: 2417: 2408: 2404: 2400: 2396: 2392: 2388: 2384: 2380: 2373: 2365: 2361: 2357: 2351: 2347: 2343: 2339: 2335: 2328: 2320: 2316: 2310: 2294: 2293: 2285: 2276: 2260: 2256: 2252: 2246: 2244: 2242: 2225: 2221: 2215: 2213: 2196: 2192: 2188: 2181: 2173: 2169: 2165: 2161: 2157: 2153: 2149: 2145: 2138: 2136: 2127: 2121: 2117: 2113: 2109: 2102: 2086: 2082: 2076: 2072: 2071: 2064: 2062: 2053: 2049: 2045: 2041: 2037: 2033: 2026: 2024: 2022: 2020: 2018: 2016: 2014: 2012: 2003: 1999: 1995: 1991: 1986: 1981: 1977: 1973: 1969: 1962: 1960: 1958: 1956: 1954: 1952: 1950: 1948: 1946: 1944: 1942: 1940: 1938: 1936: 1934: 1932: 1930: 1928: 1926: 1924: 1907: 1903: 1897: 1893: 1892: 1884: 1880: 1864: 1860: 1845: 1842: 1840: 1837: 1835: 1832: 1830: 1827: 1825: 1822: 1821: 1815: 1813: 1809: 1797: 1793: 1789: 1786: 1783: 1782:Aum Shinrikyo 1779: 1778:sulfuric acid 1775: 1771: 1768: 1764: 1761: 1757: 1756: 1746: 1742: 1739: 1736: 1732: 1729: 1726: 1722: 1718: 1714: 1711: 1708: 1704: 1700: 1699:Mirna Salihin 1697: 1694: 1691: 1688: 1684: 1680: 1676: 1672: 1669: 1666: 1665:Janet Overton 1663: 1660: 1657: 1654: 1650: 1649:Bruce Nickell 1647: 1644: 1640: 1636: 1633: 1630: 1627: 1624: 1620: 1616: 1612: 1608: 1605: 1602: 1599: 1596: 1592: 1589: 1586: 1583: 1580: 1579: 1570: 1565: 1562: 1558: 1554: 1551: 1547: 1543: 1542: 1533: 1529: 1525: 1521: 1517: 1514: 1511: 1507: 1504: 1500: 1499:Michael Marin 1496: 1492: 1489: 1485: 1482: 1478: 1474: 1470: 1466: 1462: 1459: 1455: 1451: 1448: 1444: 1440: 1436: 1432: 1429: 1425: 1421: 1417: 1414: 1410: 1406: 1402: 1398: 1394: 1390: 1386: 1385:suicide agent 1382: 1378: 1374: 1370: 1366: 1363: 1359: 1356: 1352: 1348: 1345: 1341: 1340: 1339: 1337: 1330: 1320: 1318: 1314: 1313:sulfuric acid 1310: 1306: 1302: 1297: 1294: 1289: 1285: 1281: 1277: 1273: 1269: 1268:Schutzstaffel 1265: 1261: 1257: 1253: 1249: 1245: 1241: 1237: 1233: 1229: 1228:the Holocaust 1225: 1221: 1217: 1213: 1209: 1202: 1198: 1194: 1189: 1180: 1178: 1174: 1170: 1166: 1161: 1159: 1155: 1151: 1148:broke out in 1147: 1125: 1120: 1116: 1108: 1104: 1100: 1096: 1093: 1091: 1088: 1087: 1084: 1082: 1078: 1074: 1070: 1066: 1062: 1059: 1055: 1049: 1045: 1042: 1039: 1038: 1034: 1030: 1023: 1019: 1017: 1014: 1013: 1008: 1003: 999: 996: 994: 991: 990: 986: 982: 979: 977: 974: 973: 965: 957: 950: 947:, a form (or 946: 943: 941: 938: 937: 933: 929: 928:mitochondrial 925: 921: 919: 916: 915: 912: 910: 906: 902: 898: 892: 891:methemoglobin 888: 885:state to the 884: 880: 877:The nitrites 876: 874: 871: 870: 866: 863: 862: 859: 857: 853: 849: 845: 840: 838: 834: 830: 826: 822: 818: 814: 810: 806: 801: 799: 795: 791: 787: 783: 773: 771: 756: 754: 750: 746: 742: 738: 733: 731: 727: 723: 719: 715: 711: 707: 703: 699: 696: 692: 688: 684: 683:Prussian blue 679: 676: 672: 668: 664: 655: 649: 645: 639: 637: 633: 629: 625: 621: 617: 612: 610: 606: 605:ATP synthesis 602: 598: 590: 586: 581: 579: 575: 571: 569: 557: 555: 551: 543: 542:bamboo shoots 539: 535: 532: 528: 524: 520: 516: 512: 509: 508:Tobacco smoke 506: 505: 504: 498: 494: 490: 486: 485:building fire 482: 479: 475: 474:sulfuric acid 471: 467: 463: 460: 456: 452: 448: 447: 446: 444: 440: 439:nitroprusside 436: 432: 424: 419: 410: 408: 404: 400: 396: 392: 382: 380: 376: 373: 369: 365: 361: 357: 353: 349: 345: 341: 337: 322: 320: 316: 312: 308: 304: 296: 292: 288: 283: 281: 277: 272: 270: 266: 262: 258: 254: 250: 246: 242: 238: 233: 231: 227: 223: 219: 215: 211: 207: 203: 199: 195: 191: 183: 179: 175: 172: 168: 165: 164:blood lactate 161: 159: 155: 151: 147: 143: 140: 138: 134: 130: 127: 123: 119: 115: 112: 108: 104: 100: 95: 91: 88: 86: 82: 79: 75: 72: 70: 66: 62: 58: 54: 49: 45: 41: 36: 30: 19: 5720: 5708: 5696: 5491:Latrodectism 5482:spider venom 5305:Haff disease 5226:Dipyridamole 5168:Barbiturates 5078: 5052: 4840:Toxic metals 4732: 4708: 4697: 4682: 4667: 4627: 4598: 4576: 4520: 4514: 4502:. Retrieved 4498:the original 4490: 4480: 4469:the original 4456: 4448: 4443: 4425: 4410: 4384:. Retrieved 4375: 4365: 4353:. Retrieved 4345:The Guardian 4344: 4334: 4322:. Retrieved 4311: 4302: 4290:. Retrieved 4279: 4267:. Retrieved 4258: 4248: 4236:. Retrieved 4227: 4218: 4204: 4192:. Retrieved 4183: 4174: 4150: 4143: 4131:. Retrieved 4122: 4112: 4104: 4089: 4079:27 September 4077:. Retrieved 4068: 4059: 4049:27 September 4047:. Retrieved 4039:Safety Blog® 4038: 4029: 4017:. Retrieved 4013:the original 4008: 3999: 3987:. Retrieved 3983:the original 3973: 3960: 3951: 3942: 3922: 3912: 3905: 3900: 3882: 3870:. Retrieved 3856: 3843:. Retrieved 3829: 3817: 3805: 3789: 3777: 3765: 3746: 3740: 3728:. Retrieved 3718: 3711: 3699: 3687: 3675: 3663: 3651:. Retrieved 3636: 3629: 3617:. Retrieved 3608: 3598: 3586:. Retrieved 3572: 3537: 3534:J. Med. Chem 3533: 3523: 3488: 3484: 3474: 3452:(1): 29–33. 3449: 3445: 3439: 3406: 3402: 3396: 3371: 3367: 3361: 3348: 3338: 3321: 3317: 3311: 3287: 3280: 3263: 3257: 3251: 3238: 3207: 3195:. Retrieved 3181: 3168: 3164: 3154:15 September 3152:. Retrieved 3148: 3139: 3126: 3122: 3109: 3100: 3091: 3048: 3044: 3031: 3019:. Retrieved 3010: 3000: 2965: 2961: 2951: 2932: 2911:. Retrieved 2884: 2880: 2870: 2852:Biochemistry 2851: 2809: 2805: 2799: 2754: 2750: 2740: 2721: 2715: 2696: 2692: 2682: 2649: 2645: 2639: 2609:(2): 87–95. 2606: 2602: 2596: 2582:cite journal 2563: 2559: 2549: 2524: 2520: 2514: 2489: 2483: 2477: 2465:. Retrieved 2432: 2428: 2385:(1): 37–41. 2382: 2378: 2372: 2337: 2333: 2327: 2309: 2297:. Retrieved 2291: 2284: 2275: 2263:. Retrieved 2254: 2228:. Retrieved 2199:. Retrieved 2190: 2180: 2147: 2143: 2107: 2101: 2089:. Retrieved 2069: 2035: 2031: 1975: 1971: 1910:. Retrieved 1890: 1883: 1863: 1812:biosynthesis 1806: 1770:Tokyo subway 1731:Mei Xiang Li 1713:Jolly Thomas 1679:heart attack 1488:Leonard Lake 1473:Port Kaituma 1411:(1945), and 1397:Adolf Hitler 1393:Erwin Rommel 1389:Nazi Germany 1381:prussic acid 1367:In the 1943 1355:Buenos Aires 1333: 1298: 1232:gas chambers 1220:Nazi Germany 1205: 1183:Gas chambers 1177:polyurethane 1162: 1150:Buenos Aires 1143: 1119: 1103:metabolizing 1081:parenterally 1051: 1033:madeira wine 894: 867:Description 841: 809:amyl nitrite 802: 786:amyl nitrite 779: 767: 734: 730:spinal fluid 718:heart attack 698:fluorescence 680: 661: 640: 624:amyl nitrite 613: 582: 567: 563: 547: 502: 489:polyurethane 431:prussic acid 428: 407:miscarriages 388: 333: 311:mass suicide 297:(vitamin B12 284: 273: 253:insecticides 234: 189: 188: 150:insecticides 137:Risk factors 98: 89: 29: 5753:Neurotoxins 5722:WikiProject 5535:Fish toxins 5496:Loxoscelism 5409:Snake venom 5381:Physalaemin 5353:vertebrates 5193:Paracetamol 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Index

Cyanide toxicity

Cyanide
Specialty
Toxicology
critical care medicine
Symptoms
fast heart rate
seizures
slow heart rate
cardiac arrest
Cyanide
Risk factors
House fire
metal polishing
insecticides
Diagnostic method
blood lactate
Decontamination
supportive care
hydroxocobalamin
poisoning
cyanide
headache
dizziness
fast heart rate
shortness of breath
seizures
slow heart rate
low blood pressure

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