66:-induced secreted proteins, they comprise the CCN family of matricellular proteins. These proteins have now been renamed CCN1-6 by international consensus. Members of the CCN protein family are characterized by having four conserved
845:
838:
831:
17:
891:
71:
239:
Kular L, Pakradouni J, Kitabgi P, Laurent M, Martinerie C (March 2011). "The CCN family: a new class of inflammation modulators?".
1087:
413:
Brigstock DR, Goldschmeding R, Katsube KI, Lam SC, Lau LF, Lyons K, Naus C, Perbal B, Riser B, Takigawa M, Yeger H (April 2003).
677:
1000:
1049:
985:
75:
801:
896:
995:
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464:"Regulation of the CCN genes by vitamin D: A possible adjuvant therapy in the treatment of cancer and fibrosis"
823:
1069:
990:
970:
876:
817:
86:
motif. CCN proteins have been shown to play important roles in many cellular processes, including
871:
114:. CCN proteins likely constitute a hub for the coordination of cell signaling and communication.
975:
39:
1107:
855:
63:
374:"All in the CCN family: essential matricellular signaling modulators emerge from the bunker"
31:
8:
881:
50:
The acronym CCN is derived from the first three members of the family discovered, namely
980:
776:
751:
727:
702:
633:
608:
584:
559:
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510:
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349:
324:
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91:
189:"Taking aim at the extracellular matrix: CCN proteins as emerging therapeutic targets"
781:
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463:
448:
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358:
309:
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222:
103:
1074:
1059:
430:
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1012:
804:. BioMolecular Concepts. 4(5), 477–494, DOI: 10.1515/bmc-2013-0018,
141:
99:
79:
59:
390:
373:
965:
95:
204:
1007:
802:
CCN family acting throughout the body: recent research developments
107:
67:
276:"Functions and mechanisms of action of CCN matricellular proteins"
412:
906:
38:. Due to their dynamic role within the ECM they are considered
560:"CCN1/CYR61: the very model of a modern matricellular protein"
325:"The CCN family of proteins: structure-function relationships"
1044:
949:
944:
939:
934:
929:
924:
919:
914:
238:
162:
155:
148:
127:
51:
462:
Piszczatowski, Richard T.; Lents, Nathan H. (October 2016).
122:
The CCN protein family includes the following six proteins:
62:(nephroblastoma overexpressed or CCN3). Together with three
1027:
1022:
1017:
134:
102:. They are also involved in biological processes including
55:
752:"On how CCN6 suppresses breast cancer growth and invasion"
322:
78:(VWC), the thrombospondin type 1 repeat (TSR), and a
511:"CCN proteins; A Centralized Communication Network"
609:"Roles for CCN2 in normal physiological processes"
461:
323:Holbourn KP, Acharya KR, Perbal B (October 2008).
660:. Advances in Experimental Medicine and Biology.
1099:
854:Intercellular signaling peptides and proteins /
656:Perbal B (2006). "The CCN3 protein and cancer".
606:
58:(connective tissue growth factor or CCN2), and
54:(cysteine-rich angiogenic protein 61 or CCN1),
700:
839:
749:
743:
694:
649:
600:
371:
234:
232:
182:
180:
178:
165:(WNT1 inducible signaling pathway protein-3)
158:(WNT1 inducible signaling pathway protein-2)
151:(WNT1 inducible signaling pathway protein-1)
892:Transforming growth factor beta superfamily
800:Satoshi Kubota, Masaharu Takigawa (2013)
551:
502:
406:
365:
316:
267:
846:
832:
816:at the U.S. National Library of Medicine
775:
726:
632:
583:
534:
438:
415:"Proposal for a unified CCN nomenclature"
389:
348:
299:
229:
212:
175:
72:insulin-like growth factor-binding domain
655:
508:
750:Huang W, Pal A, Kleer CG (March 2012).
701:Russo JW, Castellot JJ (October 2010).
607:Hall-Glenn F, Lyons KM (October 2011).
273:
14:
1100:
557:
186:
34:(ECM)-associated proteins involved in
827:
372:Leask A, Abraham DJ (December 2006).
130:(cysteine-rich angiogenic protein 61)
1001:Nephroblastoma overexpressed protein
814:CCN+Intercellular+Signaling+Proteins
1050:Parathyroid hormone-related protein
986:CCN intercellular signaling protein
703:"CCN5: biology and pathophysiology"
76:Von Willebrand factor type C domain
24:
18:CCN intercellular signaling protein
897:Vascular endothelial growth factor
795:
25:
1119:
807:
137:(connective tissue growth factor)
70:-rich domains, which include the
187:Jun JI, Lau LF (December 2011).
996:Connective tissue growth factor
1088:extracellular ligand disorders
1065:Tolloid-like metalloproteinase
887:Platelet-derived growth factor
455:
274:Chen CC, Lau LF (April 2009).
144:(nephroblastoma overexpressed)
13:
1:
480:10.1016/j.cellsig.2016.07.009
169:
94:, differentiation, survival,
45:
292:10.1016/j.biocel.2008.07.025
253:10.1016/j.biochi.2010.11.010
7:
670:10.1007/978-1-4020-5133-3_3
10:
1124:
341:10.1016/j.tibs.2008.07.006
280:Int. J. Biochem. Cell Biol
117:
1083:
958:
905:
862:
768:10.1007/s12079-011-0148-9
719:10.1007/s12079-010-0098-7
625:10.1007/s00018-011-0782-7
576:10.1007/s00018-011-0778-3
527:10.1007/s12079-013-0193-7
991:Cysteine-rich protein 61
971:Agouti signaling protein
877:Fibroblast growth factor
818:Medical Subject Headings
509:Perbal B (August 2013).
872:Epidermal growth factor
558:Lau LF (October 2011).
515:J. Cell. Commun. Signal
36:intercellular signaling
976:Agouti-related protein
40:matricellular proteins
1070:Tumor necrosis factor
756:J Cell Commun Signal
707:J Cell Commun Signal
110:, wound healing and
32:extracellular matrix
882:Nerve growth factor
658:Adv. Exp. Med. Biol
613:Cell. Mol. Life Sci
564:Cell. Mol. Life Sci
468:Cellular Signalling
431:10.1136/mp.56.2.127
329:Trends Biochem. Sci
193:Nat Rev Drug Discov
82:domain (CT) with a
981:Angiogenic protein
384:(Pt 23): 4803–10.
1095:
1094:
679:978-1-4020-4966-8
474:(10): 1604–1613.
391:10.1242/jcs.03270
16:(Redirected from
1115:
1035:Hedgehog protein
848:
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106:, inflammation,
30:are a family of
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796:Further reading
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619:(19): 3209–17.
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570:(19): 3149–63.
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205:10.1038/nrd3599
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864:Growth factors
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808:External links
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797:
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364:
335:(10): 461–73.
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199:(12): 945–63.
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47:
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713:(3): 119–30.
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521:(3): 169–77.
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286:(4): 771–83.
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250:
247:(3): 377–88.
246:
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129:
125:
124:
123:
115:
113:
112:tumorigenesis
109:
105:
101:
97:
93:
92:proliferation
90:, migration,
89:
88:cell adhesion
85:
84:cysteine knot
81:
77:
74:(IGFBP), the
73:
69:
65:
61:
57:
53:
43:
41:
37:
33:
29:
19:
1108:CCN proteins
1085:
799:
759:
755:
745:
710:
706:
696:
661:
657:
651:
616:
612:
602:
567:
563:
553:
518:
514:
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471:
467:
457:
425:(2): 127–8.
422:
418:
408:
381:
377:
367:
332:
328:
318:
283:
279:
269:
244:
240:
196:
192:
121:
104:angiogenesis
49:
28:CCN proteins
27:
26:
1075:Wnt protein
1060:Somatomedin
762:(1): 5–10.
419:Mol. Pathol
378:J. Cell Sci
1055:Semaphorin
1040:Interferon
1013:Endothelin
170:References
100:senescence
80:C-terminal
46:Background
1086:see also
966:Adipokine
664:: 23–40.
488:1873-3913
241:Biochimie
96:apoptosis
1102:Category
1008:Cytokine
786:21842227
737:21063502
688:17163153
643:21858450
594:21805345
545:23420091
496:27460560
449:12665631
400:17130294
359:18789696
310:18775791
261:21130134
223:22129992
108:fibrosis
68:cysteine
856:ligands
777:3271195
728:2948116
634:3670951
585:3651699
536:3709049
440:1187305
350:2683937
301:2668982
214:3663145
140:CCN3:
118:Members
907:Ephrin
820:(MeSH)
784:
774:
735:
725:
686:
676:
641:
631:
592:
582:
543:
533:
494:
486:
447:
437:
398:
357:
347:
308:
298:
259:
221:
211:
161:CCN6:
154:CCN5:
147:CCN4:
133:CCN2:
126:CCN1:
98:, and
1045:Kinin
959:Other
950:EFNB3
945:EFNB2
940:EFNB1
935:EFNA5
930:EFNA4
925:EFNA3
920:EFNA2
915:EFNA1
163:WISP3
156:WISP2
149:WISP1
128:CYR61
52:CYR61
1028:EDN3
1023:EDN2
1018:EDN1
782:PMID
733:PMID
684:PMID
674:ISBN
639:PMID
590:PMID
541:PMID
492:PMID
484:ISSN
445:PMID
396:PMID
355:PMID
306:PMID
257:PMID
219:PMID
135:CTGF
56:CTGF
772:PMC
764:doi
723:PMC
715:doi
666:doi
662:587
629:PMC
621:doi
580:PMC
572:doi
531:PMC
523:doi
476:doi
435:PMC
427:doi
386:doi
382:119
345:PMC
337:doi
296:PMC
288:doi
249:doi
209:PMC
201:doi
142:NOV
64:Wnt
60:NOV
1104::
780:.
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568:68
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376:.
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333:33
331:.
327:.
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294:.
284:41
282:.
278:.
255:.
245:93
243:.
231:^
217:.
207:.
197:10
195:.
191:.
177:^
42:.
847:e
840:t
833:v
788:.
766::
760:6
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717::
711:4
690:.
668::
645:.
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519:7
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203::
20:)
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