242:
219:
141:
116:
500:
493:
248:
147:
1366:
generated through the chromosomal translocation between chromosome 9 and 22. Forced expression of NOV inhibits proliferation and restores growth control in CML cells, suggesting that NOV may be an alternate target for novel therapeutics against CML.
2073:
Minamizato T, Sakamoto K, Liu T, Kokubo H, Katsube K, Perbal B, Nakamura S, Yamaguchi A (Mar 2007). "CCN3/NOV inhibits BMP-2-induced osteoblast differentiation by interacting with BMP and Notch signaling pathways".
255:
154:
1310:(CCN2) genetic knockout in mice, Nov-null mice are viable and largely normal, exhibiting only modest and transient sexually dimorphic skeletal abnormalities. However, Nov-null mice show enhanced blood vessel
1189:
The human NOV protein contains 357 amino acids with an N-terminal secretory signal peptide followed by four structurally distinct domains with homologies to insulin-like growth factor binding protein (
1334:, but enhances metastatic potential in xenotransplanted melanoma cells. NOV expression is associated with a higher risk of metastasis and worse prognosis in patients with cancers such as
1461:
Martinerie C, Viegas-Pequignot E, Guenard I, Dutrillaux B, Nguyen VC, Bernheim A, Perbal B (Dec 1992). "Physical mapping of human loci homologous to the chicken nov proto-oncogene".
2363:
Shimoyama T, Hiraoka S, Takemoto M, Koshizaka M, Tokuyama H, Tokuyama T, Watanabe A, Fujimoto M, Kawamura H, Sato S, Tsurutani Y, Saito Y, Perbal B, Koseki H, Yokote K (Apr 2010).
1875:"The nephroblastoma overexpressed gene (NOV/ccn3) protein associates with Notch1 extracellular domain and inhibits myoblast differentiation via Notch signaling pathway"
2595:
Vallacchi V, Daniotti M, Ratti F, Di Stasi D, Deho P, De
Filippo A, Tragni G, Balsari A, Carbone A, Rivoltini L, Parmiani G, Lazar N, Perbal B, Rodolfo M (Feb 2008).
1916:"The C-terminal domain of the regulatory protein NOVH is sufficient to promote interaction with fibulin 1C: a clue for a role of NOVH in cell-adhesion signaling"
1294:. NOV (CCN3) has recently been implicated in mood disorders, notably in the postpartum period; these effects may be mediated by its effects on myelination
2316:"Nephroblastoma overexpressed (Nov) inactivation sensitizes osteoblasts to bone morphogenetic protein-2, but nov is dispensable for skeletal homeostasis"
868:
849:
77:
2636:
Perbal B, Lazar N, Zambelli D, Lopez-Guerrero JA, Llombart-Bosch A, Scotlandi K, Picci P (Oct 2009). "Prognostic relevance of CCN3 in Ewing sarcoma".
1786:
Ellis PD, Metcalfe JC, Hyvönen M, Kemp PR (2003). "Adhesion of endothelial cells to NOV is mediated by the integrins alphavbeta3 and alpha5beta1".
1181:(CCN6) comprise the six-member CCN family in vertebrates and have been renamed CCN1-6 in the order of their discovery by international consensus.
1973:
Gupta R, Hong D, Iborra F, Sarno S, Enver T (Apr 2007). "NOV (CCN3) functions as a regulator of human hematopoietic stem or progenitor cells".
1326:
Although NOV inhibits the proliferation of cancer cells, it appears to promote metastasis. Nov overexpression results in reduced tumor size in
1443:
1425:
1290:
following damage to the myelin sheath. This finding revealed a new function for regulatory T cells that is distinct from their role in
1190:
1068:
1075:
1488:
2597:"CCN3/nephroblastoma overexpressed matricellular protein regulates integrin expression, adhesion, and dissemination in melanoma"
1603:
Brigstock DR, Goldschmeding R, Katsube KI, Lam SC, Lau LF, Lyons K, Naus C, Perbal B, Riser B, Takigawa M, Yeger H (Apr 2003).
2522:
2109:
Ouellet V, Tiedemann K, Mourskaia A, Fong JE, Tran-Thanh D, Amir E, Clemons M, Perbal B, Komarova SV, Siegel PM (May 2011).
1408:
2766:
2673:"A novel mechanism for BCR-ABL action: stimulated secretion of CCN3 is involved in growth and differentiation regulation"
2026:"Myeloid Zinc Finger 1 (MZF-1) Regulates Expression of the CCN2/CTGF and CCN3/NOV Genes in the Hematopoietic Compartment"
1387:
1194:
1158:
2464:
Benini S, Perbal B, Zambelli D, Colombo MP, Manara MC, Serra M, Parenza M, Martinez V, Picci P, Scotlandi K (Jun 2005).
241:
2265:"An analysis of Cellular Communication Network Factor Proteins as candidate mediators of postpartum psychosis risk"
218:
2466:"In Ewing's sarcoma CCN3(NOV) inhibits proliferation while promoting migration and invasion of the same cell type"
1412:
1391:
913:
2111:"CCN3 impairs osteoblast and stimulates osteoclast differentiation to favor breast cancer metastasis to bone"
2714:"CCN3 suppresses mitogenic signalling and reinstates growth control mechanisms in Chronic Myeloid Leukaemia"
2406:"Antiproliferative activity of CCN3: involvement of the C-terminal module and post-translational regulation"
894:
1249:
140:
115:
57:
1873:
Sakamoto K, Yamaguchi S, Ando R, Miyawaki A, Kabasawa Y, Takagi M, Li CL, Perbal B, Katsube K (Aug 2002).
48:, IBP-9, IGFBP-9, IGFBP9, NOVh, nephroblastoma overexpressed, cellular communication network factor 3, NOV
2546:
Gupta N, Wang H, McLeod TL, Naus CC, Kyurkchiev S, Advani S, Yu J, Perbal B, Weichselbaum RR (Oct 2001).
2405:
254:
153:
2404:
Bleau AM, Planque N, Lazar N, Zambelli D, Ori A, Quan T, Fisher G, Scotlandi K, Perbal B (Aug 2007).
247:
146:
2365:"CCN3 inhibits neointimal hyperplasia through modulation of smooth muscle cell growth and migration"
44:
1347:
1283:
65:
1161:). The CCN acronym is derived from the first three members of the family being identified, namely
1834:"Integrin-dependent functions of the angiogenic inducer NOV (CCN3): implication in wound healing"
1242:
1051:
1030:
1004:
983:
2199:
Dombrowski Y, O'Hagan T, Dittmer M, Penalva R, Mayoral SR, Bankhead P, et al. (May 2017).
2771:
1265:
1245:
from umbilical cord blood. Nov is regulated by the hematopoietic transcription factor MZF-1.
1135:
1703:"All in the CCN family: essential matricellular signaling modulators emerge from the bunker"
1982:
1927:
1222:
1154:
129:
1314:
thickening when challenged with vascular injury, indicating that NOV inhibits neoinitimal
85:
8:
1986:
1931:
2738:
2713:
2572:
2547:
2446:
2340:
2315:
2314:
Canalis E, Smerdel-Ramoya A, Durant D, Economides AN, Beamer WG, Zanotti S (Jan 2010).
2291:
2264:
2225:
2200:
2135:
2110:
2055:
2006:
1811:
1678:
1653:
1629:
1604:
1580:
1555:
1531:
1506:
1335:
1257:
1218:
89:
2671:
McCallum L, Price S, Planque N, Perbal B, Pierce A, Whetton AD, Irvine AE (Sep 2006).
2160:"Nephroblastoma overexpressed (Nov) inhibits osteoblastogenesis and causes osteopenia"
1507:"Taking aim at the extracellular matrix: CCN proteins as emerging therapeutic targets"
783:
778:
773:
768:
763:
758:
753:
748:
743:
738:
733:
728:
723:
718:
713:
708:
703:
698:
693:
688:
683:
678:
673:
668:
663:
658:
653:
648:
643:
627:
622:
617:
612:
607:
602:
597:
592:
587:
582:
566:
561:
556:
551:
546:
541:
2743:
2694:
2653:
2618:
2577:
2528:
2518:
2487:
2438:
2386:
2345:
2296:
2230:
2181:
2158:
Rydziel S, Stadmeyer L, Zanotti S, Durant D, Smerdel-Ramoya A, Canalis E (Jul 2007).
2140:
2091:
2047:
1998:
1955:
1950:
1915:
1896:
1855:
1803:
1768:
1724:
1683:
1634:
1585:
1536:
1470:
1276:
1256:
differentiation, and stimulate osteoclastogenesis through a process that may involve
1226:
37:
2450:
2010:
1815:
2733:
2725:
2684:
2645:
2608:
2567:
2559:
2510:
2477:
2428:
2420:
2376:
2335:
2327:
2286:
2276:
2220:
2212:
2171:
2130:
2122:
2083:
2059:
2037:
1990:
1945:
1935:
1886:
1845:
1795:
1758:
1714:
1673:
1665:
1624:
1616:
1575:
1567:
1526:
1518:
1363:
1169:(connective tissue growth factor, or CCN2), and NOV. These proteins, together with
334:
265:
209:
164:
69:
2649:
2613:
2596:
2689:
2672:
2126:
1669:
1280:
309:
93:
2514:
2509:. Advances in Experimental Medicine and Biology. Vol. 587. pp. 23–40.
2024:
Piszczatowski RT, Rafferty BJ, Rozado A, Parziale JV, Lents NH (November 2015).
1448:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1430:
National Center for
Biotechnology Information, U.S. National Library of Medicine
2381:
2364:
2087:
1920:
Proceedings of the
National Academy of Sciences of the United States of America
1571:
1214:
410:
2729:
2201:"Regulatory T cells promote myelin regeneration in the central nervous system"
2760:
2281:
2243:
1343:
1210:
1198:
528:
1994:
470:
348:
2747:
2698:
2657:
2622:
2581:
2532:
2491:
2482:
2465:
2442:
2390:
2349:
2300:
2234:
2185:
2176:
2159:
2144:
2095:
2051:
2002:
1900:
1891:
1874:
1859:
1850:
1833:
1807:
1772:
1763:
1746:
1728:
1687:
1638:
1589:
1540:
1460:
1238:
327:
106:
2548:"Inhibition of glioma cell growth and tumorigenic potential by CCN3 (NOV)"
1959:
1940:
1474:
1115:
1110:
499:
492:
2433:
2331:
1914:
Perbal B, Martinerie C, Sainson R, Werner M, He B, Roizman B (Feb 1999).
1315:
1291:
958:
939:
2563:
1745:
Lin CG, Leu SJ, Chen N, Tebeau CM, Lin SX, Yeung CY, Lau LF (Jun 2003).
1620:
1275:
In
February 2017, it was reported that the NOV protein was involved in
1269:
1261:
1253:
226:
123:
73:
2424:
2042:
2025:
1799:
1747:"CCN3 (NOV) is a novel angiogenic regulator of the CCN protein family"
1719:
1702:
2313:
1331:
1311:
813:
293:
280:
192:
179:
81:
2712:
McCallum L, Lu W, Price S, Lazar N, Perbal B, Irvine AE (Mar 2012).
2216:
1522:
2198:
2023:
1359:
1355:
1339:
1099:
1654:"Functions and mechanisms of action of CCN matricellular proteins"
2635:
2362:
925:
880:
798:
794:
1602:
61:
1351:
1327:
1287:
1230:
1083:
835:
508:
2594:
1832:
Lin CG, Chen CC, Leu SJ, Grzeszkiewicz TM, Lau LF (Mar 2005).
1556:"The CCN family of proteins: structure-function relationships"
2157:
2108:
1913:
1872:
1303:
1234:
1178:
1174:
1170:
1162:
1658:
2463:
2072:
1307:
1166:
1142:
2670:
2403:
1785:
317:
1831:
674:
negative regulation of SMAD protein signal transduction
1553:
1237:). NOV is expressed during wound healing and induces
1209:
NOV regulates multiple cellular activities including
482:
2711:
1972:
1489:"Entrez Gene: NOV nephroblastoma overexpressed gene"
1350:(CML), NOV is downregulated as a consequence of the
2545:
2192:
2076:
1241:in vivo. It is essential for self-renewal of CD34+
2369:Arteriosclerosis, Thrombosis, and Vascular Biology
1404:
1402:
1400:
1383:
1381:
1379:
1260:flux. Overexpression of Nov in transgenic mice in
1225:, and survival. It functions by direct binding to
664:negative regulation of sensory perception of pain
264:
163:
2758:
2505:Perbal B (2006). "The CCN3 Protein and Cancer".
1744:
1165:(cysteine-rich angiogenic inducer 61, or CCN1),
684:negative regulation of chondrocyte proliferation
2241:
1397:
1376:
1153:NOV is a member of the CCN family of secreted,
16:Protein-coding gene in the species Homo sapiens
1554:Holbourn KP, Acharya KR, Perbal B (Oct 2008).
1500:
1498:
1409:GRCm38: Ensembl release 89: ENSMUSG00000037362
1157:(ECM)-associated signaling proteins (see also
774:negative regulation of NIK/NF-kappaB signaling
754:positive regulation of Notch signaling pathway
724:negative regulation of myotube differentiation
1297:
1197:), thrombospondin type 1 repeat (TSR), and a
1130:(nephroblastoma overexpressed) also known as
2705:
2664:
2629:
2588:
2539:
2498:
2457:
2397:
2356:
2307:
2256:
2151:
2102:
2066:
1966:
1866:
1779:
1700:
1694:
1645:
744:negative regulation of inflammatory response
2718:Journal of Cell Communication and Signaling
1907:
1827:
1825:
1740:
1738:
1596:
1547:
1495:
1388:GRCh38: Ensembl release 89: ENSG00000136999
1454:
694:negative regulation of monocyte chemotaxis
2737:
2688:
2612:
2571:
2507:New trends in cancer for the 21st century
2481:
2432:
2380:
2339:
2290:
2280:
2224:
2175:
2134:
2041:
1949:
1939:
1890:
1849:
1762:
1718:
1677:
1628:
1605:"Proposal for a unified CCN nomenclature"
1579:
1530:
1201:motif within the C-terminal (CT) domain.
769:regulation of signaling receptor activity
1822:
1735:
654:negative regulation of insulin secretion
628:collagen-containing extracellular matrix
588:intracellular membrane-bounded organelle
1651:
1252:and inhibit its functions in promoting
2759:
2504:
2262:
1504:
1481:
1229:, as well as other receptors such as
269:
230:
225:
168:
127:
122:
749:type B pancreatic cell proliferation
2164:The Journal of Biological Chemistry
1879:The Journal of Biological Chemistry
1838:The Journal of Biological Chemistry
1751:The Journal of Biological Chemistry
1159:CCN intercellular signaling protein
649:hematopoietic stem cell homeostasis
13:
1193:), von Willebrand type C repeats (
704:negative regulation of cell growth
699:cell adhesion mediated by integrin
542:insulin-like growth factor binding
14:
2783:
2244:"Paralysis inspires MS discovery"
2242:James Gallagher (13 March 2017).
2115:The American Journal of Pathology
1321:
1138:that in humans is encoded by the
764:negative regulation of cell death
2413:Journal of Cellular Biochemistry
1701:Leask A, Abraham DJ (Dec 2006).
1302:In contrast to the lethality of
739:smooth muscle cell proliferation
498:
491:
253:
246:
240:
217:
152:
145:
139:
114:
2017:
2030:Journal of Cellular Physiology
1560:Trends in Biochemical Sciences
1511:Nature Reviews. Drug Discovery
1436:
1418:
679:endothelial cell-cell adhesion
509:More reference expression data
471:More reference expression data
441:Region I of hippocampus proper
1:
2650:10.1016/j.humpath.2009.05.008
2614:10.1158/0008-5472.CAN-07-2103
1370:
1148:
734:regulation of gene expression
421:tunica media of zone of aorta
238:
137:
2690:10.1182/blood-2006-04-016113
2127:10.1016/j.ajpath.2011.01.033
1788:Journal of Vascular Research
1670:10.1016/j.biocel.2008.07.025
1652:Chen CC, Lau LF (Apr 2009).
1184:
669:smooth muscle cell migration
7:
2767:Genes on human chromosome 8
2515:10.1007/978-1-4020-5133-3_3
1505:Jun JI, Lau LF (Dec 2011).
1204:
719:endothelial cell chemotaxis
659:chondrocyte differentiation
10:
2788:
2382:10.1161/ATVBAHA.110.203356
2088:10.1016/j.bbrc.2007.01.029
1572:10.1016/j.tibs.2008.07.006
1298:Role in embryo development
2730:10.1007/s12079-011-0142-2
1444:"Mouse PubMed Reference:"
1426:"Human PubMed Reference:"
1264:antagonizes both BMP and
1114:
1109:
1105:
1098:
1082:
1069:Chr 8: 119.42 – 119.42 Mb
1063:
1048:
1044:
1027:
1023:
1016:
1001:
997:
980:
976:
969:
956:
952:
937:
933:
924:
911:
907:
892:
888:
879:
866:
862:
847:
843:
834:
819:
812:
808:
792:
709:regulation of cell growth
527:
523:
506:
490:
481:
468:
417:
408:
391:Descending thoracic aorta
355:
346:
316:
308:
304:
287:
274:
237:
216:
207:
203:
186:
173:
136:
113:
104:
100:
55:
52:
42:
35:
30:
26:
21:
2282:10.3389/fpsyt.2019.00876
1348:chronic myeloid leukemia
1243:hematopoietic stem cells
1076:Chr 15: 54.61 – 54.62 Mb
449:anterior amygdaloid area
2269:Frontiers in Psychiatry
1995:10.1126/science.1136031
1707:Journal of Cell Science
1286:in the regeneration of
453:suprachiasmatic nucleus
2483:10.1038/sj.onc.1208620
2177:10.1074/jbc.M700212200
1892:10.1074/jbc.M203727200
1851:10.1074/jbc.M404903200
1764:10.1074/jbc.M302028200
562:growth factor activity
271:15 D1|15 21.49 cM
2263:Davies W (Nov 2019).
1941:10.1073/pnas.96.3.869
1136:matricellular protein
359:right coronary artery
232:Chromosome 15 (mouse)
2332:10.1210/en.2009-0574
1155:extracellular matrix
644:fibroblast migration
598:extracellular region
593:extracellular matrix
375:right adrenal cortex
130:Chromosome 8 (human)
2564:10.1136/mp.54.5.293
2552:Molecular Pathology
2205:Nature Neuroscience
1987:2007Sci...316..590G
1932:1999PNAS...96..869P
1621:10.1136/mp.56.2.127
1609:Molecular Pathology
784:signal transduction
759:cell-cell signaling
371:right adrenal gland
367:left adrenal cortex
1713:(Pt 23): 4803–10.
1227:integrin receptors
914:ENSMUSG00000037362
637:Biological process
608:neuronal cell body
576:Cellular component
535:Molecular function
2524:978-1-4020-4966-8
2425:10.1002/jcb.21262
2043:10.1002/jcp.25021
2036:(11): 2634–2639.
1885:(33): 29399–405.
1800:10.1159/000071887
1720:10.1242/jcs.03270
1277:regulatory T cell
1125:
1124:
1121:
1120:
1094:
1093:
1059:
1058:
1038:
1037:
1012:
1011:
991:
990:
965:
964:
946:
945:
920:
919:
901:
900:
875:
874:
856:
855:
804:
803:
689:bone regeneration
519:
518:
515:
514:
477:
476:
464:
463:
402:
401:
300:
299:
199:
198:
2779:
2752:
2751:
2741:
2709:
2703:
2702:
2692:
2668:
2662:
2661:
2633:
2627:
2626:
2616:
2592:
2586:
2585:
2575:
2543:
2537:
2536:
2502:
2496:
2495:
2485:
2461:
2455:
2454:
2436:
2410:
2401:
2395:
2394:
2384:
2360:
2354:
2353:
2343:
2311:
2305:
2304:
2294:
2284:
2260:
2254:
2251:
2238:
2228:
2196:
2190:
2189:
2179:
2170:(27): 19762–72.
2155:
2149:
2148:
2138:
2106:
2100:
2099:
2070:
2064:
2063:
2045:
2021:
2015:
2014:
1970:
1964:
1963:
1953:
1943:
1911:
1905:
1904:
1894:
1870:
1864:
1863:
1853:
1829:
1820:
1819:
1783:
1777:
1776:
1766:
1742:
1733:
1732:
1722:
1698:
1692:
1691:
1681:
1649:
1643:
1642:
1632:
1600:
1594:
1593:
1583:
1551:
1545:
1544:
1534:
1502:
1493:
1492:
1485:
1479:
1478:
1458:
1452:
1451:
1440:
1434:
1433:
1422:
1416:
1406:
1395:
1385:
1364:chimeric protein
1292:immunomodulation
1233:and fibulin 1c (
1107:
1106:
1078:
1071:
1054:
1042:
1041:
1033:
1021:
1020:
1017:RefSeq (protein)
1007:
995:
994:
986:
974:
973:
950:
949:
931:
930:
905:
904:
886:
885:
860:
859:
841:
840:
810:
809:
552:integrin binding
525:
524:
511:
502:
495:
488:
487:
473:
413:
411:Top expressed in
406:
405:
383:popliteal artery
351:
349:Top expressed in
344:
343:
323:
322:
306:
305:
296:
283:
272:
257:
250:
244:
233:
221:
205:
204:
195:
182:
171:
156:
149:
143:
132:
118:
102:
101:
96:
94:CCN3 - orthologs
47:
40:
19:
18:
2787:
2786:
2782:
2781:
2780:
2778:
2777:
2776:
2757:
2756:
2755:
2710:
2706:
2669:
2665:
2644:(10): 1479–86.
2638:Human Pathology
2634:
2630:
2601:Cancer Research
2593:
2589:
2544:
2540:
2525:
2503:
2499:
2476:(27): 4349–61.
2462:
2458:
2408:
2402:
2398:
2361:
2357:
2312:
2308:
2261:
2257:
2217:10.1038/nn.4528
2197:
2193:
2156:
2152:
2107:
2103:
2071:
2067:
2022:
2018:
1981:(5824): 590–3.
1971:
1967:
1912:
1908:
1871:
1867:
1830:
1823:
1784:
1780:
1757:(26): 24200–8.
1743:
1736:
1699:
1695:
1650:
1646:
1601:
1597:
1552:
1548:
1523:10.1038/nrd3599
1503:
1496:
1487:
1486:
1482:
1469:(12): 2529–34.
1459:
1455:
1442:
1441:
1437:
1424:
1423:
1419:
1407:
1398:
1386:
1377:
1373:
1336:Ewing's sarcoma
1324:
1300:
1284:differentiation
1281:oligodendrocyte
1223:differentiation
1207:
1187:
1151:
1116:View/Edit Mouse
1111:View/Edit Human
1074:
1067:
1064:Location (UCSC)
1050:
1029:
1003:
982:
895:ENSG00000136999
788:
729:cell chemotaxis
632:
571:
567:heparin binding
557:protein binding
507:
497:
496:
469:
460:
455:
451:
447:
443:
439:
435:
431:
429:ascending aorta
427:
423:
409:
398:
393:
389:
387:tibial arteries
385:
381:
379:ascending aorta
377:
373:
369:
365:
361:
347:
291:
278:
270:
260:
259:
258:
251:
231:
208:Gene location (
190:
177:
169:
159:
158:
157:
150:
128:
105:Gene location (
56:
43:
36:
17:
12:
11:
5:
2785:
2775:
2774:
2769:
2754:
2753:
2704:
2683:(5): 1716–23.
2663:
2628:
2587:
2538:
2523:
2497:
2456:
2419:(6): 1475–91.
2396:
2355:
2306:
2255:
2253:
2252:
2211:(5): 674–680.
2191:
2150:
2121:(5): 2377–88.
2101:
2065:
2016:
1965:
1906:
1865:
1844:(9): 8229–37.
1821:
1778:
1734:
1693:
1644:
1595:
1566:(10): 461–73.
1546:
1517:(12): 945–63.
1494:
1480:
1453:
1435:
1417:
1396:
1374:
1372:
1369:
1323:
1322:Role in cancer
1320:
1299:
1296:
1268:and result in
1206:
1203:
1186:
1183:
1150:
1147:
1123:
1122:
1119:
1118:
1113:
1103:
1102:
1096:
1095:
1092:
1091:
1089:
1087:
1080:
1079:
1072:
1065:
1061:
1060:
1057:
1056:
1046:
1045:
1039:
1036:
1035:
1025:
1024:
1018:
1014:
1013:
1010:
1009:
999:
998:
992:
989:
988:
978:
977:
971:
967:
966:
963:
962:
954:
953:
947:
944:
943:
935:
934:
928:
922:
921:
918:
917:
909:
908:
902:
899:
898:
890:
889:
883:
877:
876:
873:
872:
864:
863:
857:
854:
853:
845:
844:
838:
832:
831:
826:
821:
817:
816:
806:
805:
802:
801:
790:
789:
787:
786:
781:
776:
771:
766:
761:
756:
751:
746:
741:
736:
731:
726:
721:
716:
711:
706:
701:
696:
691:
686:
681:
676:
671:
666:
661:
656:
651:
646:
640:
638:
634:
633:
631:
630:
625:
620:
615:
610:
605:
600:
595:
590:
585:
579:
577:
573:
572:
570:
569:
564:
559:
554:
549:
544:
538:
536:
532:
531:
521:
520:
517:
516:
513:
512:
504:
503:
485:
479:
478:
475:
474:
466:
465:
462:
461:
459:
458:
454:
450:
446:
442:
438:
434:
430:
426:
422:
418:
415:
414:
403:
400:
399:
397:
396:
395:saphenous vein
392:
388:
384:
380:
376:
372:
368:
364:
363:adrenal cortex
360:
356:
353:
352:
340:
339:
331:
320:
314:
313:
310:RNA expression
302:
301:
298:
297:
289:
285:
284:
276:
273:
268:
262:
261:
252:
245:
239:
235:
234:
229:
223:
222:
214:
213:
201:
200:
197:
196:
188:
184:
183:
175:
172:
167:
161:
160:
151:
144:
138:
134:
133:
126:
120:
119:
111:
110:
98:
97:
54:
50:
49:
41:
33:
32:
28:
27:
24:
23:
15:
9:
6:
4:
3:
2:
2784:
2773:
2770:
2768:
2765:
2764:
2762:
2749:
2745:
2740:
2735:
2731:
2727:
2723:
2719:
2715:
2708:
2700:
2696:
2691:
2686:
2682:
2678:
2674:
2667:
2659:
2655:
2651:
2647:
2643:
2639:
2632:
2624:
2620:
2615:
2610:
2607:(3): 715–23.
2606:
2602:
2598:
2591:
2583:
2579:
2574:
2569:
2565:
2561:
2557:
2553:
2549:
2542:
2534:
2530:
2526:
2520:
2516:
2512:
2508:
2501:
2493:
2489:
2484:
2479:
2475:
2471:
2467:
2460:
2452:
2448:
2444:
2440:
2435:
2434:2027.42/56135
2430:
2426:
2422:
2418:
2414:
2407:
2400:
2392:
2388:
2383:
2378:
2375:(4): 675–82.
2374:
2370:
2366:
2359:
2351:
2347:
2342:
2337:
2333:
2329:
2326:(1): 221–33.
2325:
2321:
2320:Endocrinology
2317:
2310:
2302:
2298:
2293:
2288:
2283:
2278:
2274:
2270:
2266:
2259:
2249:
2245:
2240:
2239:
2236:
2232:
2227:
2222:
2218:
2214:
2210:
2206:
2202:
2195:
2187:
2183:
2178:
2173:
2169:
2165:
2161:
2154:
2146:
2142:
2137:
2132:
2128:
2124:
2120:
2116:
2112:
2105:
2097:
2093:
2089:
2085:
2082:(2): 567–73.
2081:
2077:
2069:
2061:
2057:
2053:
2049:
2044:
2039:
2035:
2031:
2027:
2020:
2012:
2008:
2004:
2000:
1996:
1992:
1988:
1984:
1980:
1976:
1969:
1961:
1957:
1952:
1947:
1942:
1937:
1933:
1929:
1926:(3): 869–74.
1925:
1921:
1917:
1910:
1902:
1898:
1893:
1888:
1884:
1880:
1876:
1869:
1861:
1857:
1852:
1847:
1843:
1839:
1835:
1828:
1826:
1817:
1813:
1809:
1805:
1801:
1797:
1794:(3): 234–43.
1793:
1789:
1782:
1774:
1770:
1765:
1760:
1756:
1752:
1748:
1741:
1739:
1730:
1726:
1721:
1716:
1712:
1708:
1704:
1697:
1689:
1685:
1680:
1675:
1671:
1667:
1664:(4): 771–83.
1663:
1659:
1655:
1648:
1640:
1636:
1631:
1626:
1622:
1618:
1614:
1610:
1606:
1599:
1591:
1587:
1582:
1577:
1573:
1569:
1565:
1561:
1557:
1550:
1542:
1538:
1533:
1528:
1524:
1520:
1516:
1512:
1508:
1501:
1499:
1490:
1484:
1476:
1472:
1468:
1464:
1457:
1449:
1445:
1439:
1431:
1427:
1421:
1414:
1410:
1405:
1403:
1401:
1393:
1389:
1384:
1382:
1380:
1375:
1368:
1365:
1361:
1357:
1353:
1349:
1345:
1344:breast cancer
1341:
1337:
1333:
1329:
1319:
1317:
1313:
1309:
1305:
1295:
1293:
1289:
1285:
1282:
1278:
1273:
1271:
1267:
1266:Wnt-signaling
1263:
1259:
1255:
1251:
1248:NOV can bind
1246:
1244:
1240:
1236:
1232:
1228:
1224:
1220:
1219:proliferation
1216:
1212:
1211:cell adhesion
1202:
1200:
1199:cysteine knot
1196:
1192:
1182:
1180:
1176:
1172:
1168:
1164:
1160:
1156:
1146:
1144:
1141:
1137:
1133:
1129:
1117:
1112:
1108:
1104:
1101:
1097:
1090:
1088:
1085:
1081:
1077:
1073:
1070:
1066:
1062:
1055:
1053:
1047:
1043:
1040:
1034:
1032:
1026:
1022:
1019:
1015:
1008:
1006:
1000:
996:
993:
987:
985:
979:
975:
972:
970:RefSeq (mRNA)
968:
961:
960:
955:
951:
948:
942:
941:
936:
932:
929:
927:
923:
916:
915:
910:
906:
903:
897:
896:
891:
887:
884:
882:
878:
871:
870:
865:
861:
858:
852:
851:
846:
842:
839:
837:
833:
830:
827:
825:
822:
818:
815:
811:
807:
800:
796:
791:
785:
782:
780:
779:cell adhesion
777:
775:
772:
770:
767:
765:
762:
760:
757:
755:
752:
750:
747:
745:
742:
740:
737:
735:
732:
730:
727:
725:
722:
720:
717:
715:
712:
710:
707:
705:
702:
700:
697:
695:
692:
690:
687:
685:
682:
680:
677:
675:
672:
670:
667:
665:
662:
660:
657:
655:
652:
650:
647:
645:
642:
641:
639:
636:
635:
629:
626:
624:
621:
619:
616:
614:
613:cell junction
611:
609:
606:
604:
601:
599:
596:
594:
591:
589:
586:
584:
581:
580:
578:
575:
574:
568:
565:
563:
560:
558:
555:
553:
550:
548:
547:Notch binding
545:
543:
540:
539:
537:
534:
533:
530:
529:Gene ontology
526:
522:
510:
505:
501:
494:
489:
486:
484:
480:
472:
467:
456:
452:
448:
444:
440:
436:
432:
428:
424:
420:
419:
416:
412:
407:
404:
394:
390:
386:
382:
378:
374:
370:
366:
362:
358:
357:
354:
350:
345:
342:
341:
338:
336:
332:
330:
329:
325:
324:
321:
319:
315:
311:
307:
303:
295:
290:
286:
282:
277:
267:
263:
256:
249:
243:
236:
228:
224:
220:
215:
211:
206:
202:
194:
189:
185:
181:
176:
166:
162:
155:
148:
142:
135:
131:
125:
121:
117:
112:
108:
103:
99:
95:
91:
87:
83:
79:
75:
71:
67:
63:
59:
51:
46:
39:
34:
29:
25:
20:
2772:CCN proteins
2724:(1): 27–35.
2721:
2717:
2707:
2680:
2676:
2666:
2641:
2637:
2631:
2604:
2600:
2590:
2558:(5): 293–9.
2555:
2551:
2541:
2506:
2500:
2473:
2469:
2459:
2416:
2412:
2399:
2372:
2368:
2358:
2323:
2319:
2309:
2272:
2268:
2258:
2247:
2208:
2204:
2194:
2167:
2163:
2153:
2118:
2114:
2104:
2079:
2075:
2068:
2033:
2029:
2019:
1978:
1974:
1968:
1923:
1919:
1909:
1882:
1878:
1868:
1841:
1837:
1791:
1787:
1781:
1754:
1750:
1710:
1706:
1696:
1661:
1657:
1647:
1615:(2): 127–8.
1612:
1608:
1598:
1563:
1559:
1549:
1514:
1510:
1483:
1466:
1462:
1456:
1447:
1438:
1429:
1420:
1354:activity of
1325:
1301:
1274:
1247:
1239:angiogenesis
1208:
1188:
1177:(CCN5), and
1152:
1139:
1131:
1127:
1126:
1049:
1028:
1002:
981:
957:
938:
912:
893:
867:
848:
828:
823:
714:angiogenesis
623:gap junction
445:pineal gland
433:aortic valve
333:
326:
191:119,424,434
178:119,416,446
53:External IDs
1316:hyperplasia
1306:(CCN1) and
1262:osteoblasts
437:optic nerve
292:54,617,435
279:54,609,098
31:Identifiers
2761:Categories
1415:, May 2017
1394:, May 2017
1371:References
1332:xenografts
1312:neointimal
1279:-mediated
1270:osteopenia
1254:osteogenic
1149:CCN family
337:(ortholog)
74:HomoloGene
1215:migration
1185:Structure
1052:NP_035060
1031:NP_002505
1005:NM_010930
984:NM_002514
814:Orthologs
583:cytoplasm
425:subiculum
82:GeneCards
2748:21773872
2699:16670264
2658:19695675
2623:18245471
2582:11577170
2533:17163153
2492:15824736
2470:Oncogene
2451:18256267
2443:17340618
2391:20139355
2350:19934377
2301:31849729
2248:BBC News
2235:28288125
2186:17500060
2145:21514448
2096:17250806
2052:25899830
2011:37529465
2003:17463287
1901:12050162
1860:15611078
1816:84511515
1808:12902636
1773:12695522
1729:17130294
1688:18775791
1639:12665631
1590:18789696
1541:22129992
1463:Oncogene
1411:–
1390:–
1340:melanoma
1205:Function
1173:(CCN4),
1100:Wikidata
793:Sources:
618:dendrite
2739:3271200
2573:1187085
2341:2803142
2292:6901936
2275:: 876.
2226:5409501
2136:3081179
2060:6888015
1983:Bibcode
1975:Science
1960:9927660
1928:Bibcode
1679:2668982
1630:1187305
1581:2683937
1532:3663145
1475:1334251
1413:Ensembl
1392:Ensembl
1258:calcium
926:UniProt
881:Ensembl
820:Species
799:QuickGO
312:pattern
170:8q24.12
38:Aliases
2746:
2736:
2697:
2656:
2621:
2580:
2570:
2531:
2521:
2490:
2449:
2441:
2389:
2348:
2338:
2299:
2289:
2233:
2223:
2184:
2143:
2133:
2094:
2058:
2050:
2009:
2001:
1958:
1948:
1899:
1858:
1814:
1806:
1771:
1727:
1686:
1676:
1637:
1627:
1588:
1578:
1539:
1529:
1473:
1352:kinase
1342:, and
1330:cells
1328:glioma
1288:myelin
1231:NOTCH1
1086:search
1084:PubMed
959:Q64299
940:P48745
836:Entrez
483:BioGPS
70:109185
62:164958
2677:Blood
2447:S2CID
2409:(PDF)
2056:S2CID
2007:S2CID
1951:15317
1812:S2CID
1346:. In
1304:Cyr61
1235:FBLN1
1191:IGFBP
1179:WISP3
1175:WISP2
1171:WISP1
1163:CYR61
1134:is a
869:18133
829:Mouse
824:Human
795:Amigo
457:ankle
335:Mouse
328:Human
275:Start
210:Mouse
174:Start
107:Human
2744:PMID
2695:PMID
2654:PMID
2619:PMID
2578:PMID
2529:PMID
2519:ISBN
2488:PMID
2439:PMID
2387:PMID
2346:PMID
2297:PMID
2231:PMID
2182:PMID
2141:PMID
2092:PMID
2048:PMID
1999:PMID
1956:PMID
1897:PMID
1856:PMID
1804:PMID
1769:PMID
1725:PMID
1684:PMID
1635:PMID
1586:PMID
1537:PMID
1471:PMID
1362:, a
1308:Ctgf
1250:BMP2
1167:CTGF
1143:gene
1132:CCN3
850:4856
603:axon
318:Bgee
266:Band
227:Chr.
165:Band
124:Chr.
86:CCN3
78:1884
58:OMIM
45:CCN3
22:CCN3
2734:PMC
2726:doi
2685:doi
2681:108
2646:doi
2609:doi
2568:PMC
2560:doi
2511:doi
2478:doi
2429:hdl
2421:doi
2417:101
2377:doi
2336:PMC
2328:doi
2324:151
2287:PMC
2277:doi
2221:PMC
2213:doi
2172:doi
2168:282
2131:PMC
2123:doi
2119:178
2084:doi
2080:354
2038:doi
2034:230
1991:doi
1979:316
1946:PMC
1936:doi
1887:doi
1883:277
1846:doi
1842:280
1796:doi
1759:doi
1755:278
1715:doi
1711:119
1674:PMC
1666:doi
1625:PMC
1617:doi
1576:PMC
1568:doi
1527:PMC
1519:doi
1360:ABL
1356:BCR
1195:vWC
1140:NOV
1128:NOV
288:End
187:End
90:OMA
66:MGI
2763::
2742:.
2732:.
2720:.
2716:.
2693:.
2679:.
2675:.
2652:.
2642:40
2640:.
2617:.
2605:68
2603:.
2599:.
2576:.
2566:.
2556:54
2554:.
2550:.
2527:.
2517:.
2486:.
2474:24
2472:.
2468:.
2445:.
2437:.
2427:.
2415:.
2411:.
2385:.
2373:30
2371:.
2367:.
2344:.
2334:.
2322:.
2318:.
2295:.
2285:.
2273:10
2271:.
2267:.
2246:.
2229:.
2219:.
2209:20
2207:.
2203:.
2180:.
2166:.
2162:.
2139:.
2129:.
2117:.
2113:.
2090:.
2078:.
2054:.
2046:.
2032:.
2028:.
2005:.
1997:.
1989:.
1977:.
1954:.
1944:.
1934:.
1924:96
1922:.
1918:.
1895:.
1881:.
1877:.
1854:.
1840:.
1836:.
1824:^
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