242:
219:
141:
116:
493:
248:
147:
1374:
and to exacerbate extracellular matrix production in association other fibrosis-inducing conditions. Overexpression of CTGF in fibroblasts promotes fibrosis in the dermis, kidney, and lung, and deletion of Ctgf in fibroblasts and smooth muscle cells greatly reduces
2417:
Mori T, Kawara S, Shinozaki M, Hayashi N, Kakinuma T, Igarashi A, Takigawa M, Nakanishi T, Takehara K (October 1999). "Role and interaction of connective tissue growth factor with transforming growth factor-beta in persistent fibrosis: A mouse fibrosis model".
1918:"Identification of integrin alpha(M)beta(2) as an adhesion receptor on peripheral blood monocytes for Cyr61 (CCN1) and connective tissue growth factor (CCN2): immediate-early gene products expressed in atherosclerotic lesions"
2551:
Ellina O, Chatzigeorgiou A, Kouyanou S, et al. (January 2012). "Extracellular matrix-associated (GAGs, CTGF), angiogenic (VEGF) and inflammatory factors (MCP-1, CD40, IFN-γ) in type 1 diabetes mellitus nephropathy".
1338:. Ctgf-null mice also show defects in angiogenesis, with impaired interaction between endothelial cells and pericytes and collagen IV deficiency in the endothelial basement membrane. CTGF is also important for
255:
154:
1959:"Connective tissue growth factor (CCN2) induces adhesion of rat activated hepatic stellate cells by binding of its C-terminal domain to integrin α(v)β(3) and heparan sulfate proteoglycan"
4900:
1390:, arthritis, and cardiovascular diseases. Several clinical trials are now ongoing that investigate the therapeutic value of targeting CTGF in fibrosis, diabetic nephropathy, and
2083:
Aoyama E, Hattori T, Hoshijima M, Araki D, Nishida T, Kubota S, Takigawa M (June 2009). "N-terminal domains of CCN family 2/connective tissue growth factor bind to aggrecan".
4920:
4910:
2689:
3065:
4895:
3430:
1397:
CTGF (CCN2) has recently been implicated in mood disorders, notably in the postpartum period; these effects may be mediated by its effects on myelination
2269:"Connective tissue growth factor (CTGF) inactivation leads to defects in islet cell lineage allocation and beta-cell proliferation during embryogenesis"
956:
937:
77:
4665:
2740:
4604:
3781:
2973:
2682:
2267:
Crawford LA, Guney MA, Oh YA, Deyoung RA, Valenzuela DM, Murphy AJ, Yancopoulos GD, Lyons KM, Brigstock DR, Economides A, Gannon M (March 2009).
2208:
Hall-Glenn F, De Young RA, Huang BL, van Handel B, Hofmann JJ, Chen TT, Choi A, Ong JR, Benya PD, Mikkola H, Iruela-Arispe ML, Lyons KM (2012).
5564:
3706:
2120:"Matrix metalloproteinases cleave connective tissue growth factor and reactivate angiogenic activity of vascular endothelial growth factor 165"
5288:
5201:
5146:
5100:
5045:
4780:
4720:
3721:
3651:
3210:
2808:
2750:
1491:
1473:
5283:
5161:
5060:
4846:
4735:
4535:
4495:
4243:
4162:
4024:
3965:
3927:
3872:
3867:
3857:
3731:
3726:
3696:
3671:
3666:
3656:
3542:
3461:
3400:
3328:
3307:
3292:
3245:
2898:
1869:"Activation-dependent adhesion of human platelets to Cyr61 and Fisp12/mouse connective tissue growth factor is mediated through integrin α
5383:
5241:
5220:
5176:
5156:
5075:
5055:
4770:
4750:
4730:
4373:
4368:
3701:
3425:
2958:
2755:
2210:"CCN2/connective tissue growth factor is essential for pericyte adhesion and endothelial basement membrane formation during angiogenesis"
5206:
5196:
5151:
5105:
5095:
5050:
4874:
4841:
4821:
4785:
4775:
4725:
4685:
4157:
4137:
4104:
3985:
3887:
3736:
2675:
2431:
1275:
1156:
2000:"The low density lipoprotein receptor-related protein/alpha2-macroglobulin receptor is a receptor for connective tissue growth factor"
1298:, and TrkA. In addition, CTGF also binds growth factors and extracellular matrix proteins. The N-terminal half of CTGF interacts with
5166:
5065:
4960:
4864:
4816:
4809:
4795:
4740:
4710:
4190:
4180:
4132:
4114:
4043:
3877:
3716:
3661:
2649:
1163:
4905:
4595:
4200:
3917:
2461:
Sonnylal S, Shi-Wen X, Leoni P, Naff K, Van Pelt CS, Nakamura H, Leask A, Abraham D, Bou-Gharios G, de
Crombrugghe B (May 2010).
5005:
3185:
2868:
5583:
5533:
5504:
5451:
3938:
3805:
1456:
5621:
5262:
5258:
5254:
5250:
2803:
2787:
2655:
3531:
3450:
3317:
3234:
1435:
1279:
1239:
5246:
1286:
motif. CTGF exerts its functions by binding to various cell surface receptors in a context-dependent manner, including
241:
4935:
4054:
3614:
3225:
1258:, skeletal development, and tissue wound repair, and is critically involved in fibrotic disease and several forms of
2883:
2827:
2818:
2597:"An analysis of Cellular Communication Network Factor Proteins as candidate mediators of postpartum psychosis risk"
1295:
218:
2463:"Selective expression of connective tissue growth factor in fibroblasts in vivo promotes systemic tissue fibrosis"
5457:
1812:"Fisp12/mouse connective tissue growth factor mediates endothelial cell adhesion and migration through integrin α
1460:
1439:
5544:
5520:
4660:
4216:
4079:
1001:
5510:
1916:
Schober JM, Chen N, Grzeszkiewicz TM, Jovanovic I, Emeson EE, Ugarova TP, Ye RD, Lau LF, Lam SC (June 2002).
1270:
Members of the CCN protein family, including CTGF, are structurally characterized by having four conserved,
982:
5554:
3950:
3832:
3822:
140:
115:
57:
4925:
2161:"Connective tissue growth factor coordinates chondrogenesis and angiogenesis during skeletal development"
1334:
Knockout mice with the Ctgf gene disrupted die at birth due to respiratory stress as a result of severe
1274:-rich domains. These domains are, from N- to C-termini, the insulin-like growth factor binding protein (
5539:
3365:
254:
153:
2159:
Ivkovic S, Yoon BS, Popoff SN, Safadi FF, Libuda DE, Stephenson RC, Daluiski A, Lyons KM (June 2003).
1382:
In addition to fibrosis, aberrant CTGF expression is also associated with many types of malignancies,
5447:
2041:"Connective tissue growth factor CCN2 interacts with and activates the tyrosine kinase receptor TrkA"
247:
146:
48:, HCS24, IGFBP8, NOV2, connective tissue growth factor, cellular communication network factor 2, CTGF
44:
3631:
3547:
3466:
3333:
3250:
65:
2370:"Connective tissue growth factor (CCN2, CTGF) and organ fibrosis: lessons from transgenic animals"
5626:
5231:
2978:
2853:
1139:
1118:
1092:
1071:
5515:
5131:
5035:
4655:
4074:
3060:
2698:
1291:
5631:
5589:
3786:
3070:
2709:
1282:) domain, the thrombospondin type 1 repeat (TSR) domain, and a C-terminal domain (CT) with a
1227:
1722:"All in the CCN family: essential matricellular signaling modulators emerge from the bunker"
5529:
4915:
3847:
3796:
2318:"Connective tissue growth factor is required for normal follicle development and ovulation"
2221:
1383:
1339:
1231:
129:
85:
8:
4670:
4084:
2661:
752:
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
2225:
2040:
4348:
2701:
2623:
2596:
2577:
2487:
2462:
2443:
2394:
2369:
2342:
2317:
2293:
2268:
2244:
2209:
2185:
2160:
1787:
1762:
1694:
1669:
1645:
1620:
1596:
1571:
1542:
1517:
89:
1518:"Taking aim at the extracellular matrix: CCN proteins as emerging therapeutic targets"
871:
866:
861:
856:
851:
846:
841:
836:
831:
826:
821:
816:
811:
806:
801:
796:
791:
786:
781:
776:
771:
766:
761:
756:
751:
746:
741:
736:
731:
726:
721:
716:
711:
706:
701:
696:
691:
686:
681:
676:
671:
666:
661:
656:
651:
646:
641:
636:
620:
615:
610:
605:
600:
595:
590:
585:
580:
564:
559:
554:
549:
544:
539:
534:
4975:
2628:
2569:
2533:
2492:
2435:
2399:
2347:
2298:
2249:
2190:
2141:
2100:
2065:
2021:
1980:
1939:
1898:
1849:
1844:
1811:
1792:
1743:
1699:
1650:
1601:
1547:
1406:
1391:
1287:
37:
2667:
2581:
2447:
5393:
4525:
2618:
2608:
2561:
2523:
2482:
2474:
2427:
2389:
2381:
2337:
2329:
2316:
Nagashima T, Kim J, Li Q, Lydon JP, DeMayo FJ, Lyons KM, Matzuk MM (October 2011).
2288:
2280:
2239:
2229:
2180:
2172:
2131:
2092:
2055:
2011:
1970:
1929:
1888:
1839:
1831:
1782:
1774:
1733:
1689:
1681:
1640:
1632:
1591:
1583:
1537:
1529:
1343:
1335:
334:
265:
209:
164:
69:
2234:
1998:
Segarini PR, Nesbitt JE, Li D, Hays LG, Yates JR, Carmichael DF (November 2001).
1636:
309:
93:
1496:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1478:
National Center for
Biotechnology Information, U.S. National Library of Medicine
5579:
5500:
5442:
5136:
4985:
4980:
4094:
4089:
2735:
2725:
2720:
1685:
1247:
410:
2385:
1934:
1917:
1778:
1587:
5615:
5273:
5186:
5115:
5085:
5020:
4930:
4884:
4760:
4690:
4635:
4624:
4109:
3817:
3500:
3405:
3297:
2613:
1893:
1868:
1359:
1283:
1243:
521:
470:
348:
5599:
5569:
5308:
5298:
5191:
5090:
4945:
4765:
4700:
4615:
4119:
3922:
3761:
3756:
3676:
3626:
3440:
3194:
3175:
3154:
3125:
2848:
2843:
2632:
2573:
2537:
2496:
2439:
2403:
2351:
2302:
2253:
2194:
2145:
2136:
2119:
2104:
2069:
2060:
2025:
2016:
1999:
1984:
1975:
1958:
1943:
1902:
1853:
1796:
1747:
1703:
1654:
1605:
1551:
1255:
492:
327:
106:
2565:
2432:
10.1002/(SICI)1097-4652(199910)181:1<153::AID-JCP16>3.0.CO;2-K
2118:
Hashimoto G, Inoki I, Fujii Y, Aoki T, Ikeda E, Okada Y (September 2002).
1835:
1203:
1198:
5559:
5525:
5423:
5413:
5408:
5398:
5348:
5171:
5070:
4831:
4745:
4675:
4570:
4333:
4298:
4248:
4211:
4147:
4029:
3960:
3912:
3902:
3897:
3892:
3776:
3771:
3766:
3144:
3055:
3045:
3013:
3008:
3003:
2998:
2988:
2948:
2913:
2333:
2284:
1387:
1319:
1307:
1251:
1046:
1027:
5378:
5343:
5338:
5328:
5318:
5236:
5025:
5000:
4990:
4836:
4790:
4650:
4476:
4445:
4414:
4383:
4328:
4303:
4283:
4268:
4258:
4152:
4069:
3862:
3842:
3741:
3686:
3681:
3505:
3410:
3395:
3190:
3149:
3121:
3090:
3050:
2953:
2908:
2903:
2878:
2873:
2863:
2776:
2770:
2760:
2096:
1820:, promotes endothelial cell survival, and induces angiogenesis in vivo"
226:
123:
73:
2528:
2511:
2478:
2176:
1738:
1721:
5403:
5373:
5368:
5363:
5358:
5353:
5333:
5323:
5313:
5303:
4995:
4955:
4851:
4826:
4585:
4580:
4575:
4565:
4560:
4555:
4545:
4466:
4404:
4338:
4318:
4313:
4308:
4293:
4288:
4278:
4273:
4167:
4142:
3907:
3827:
3746:
3691:
3581:
3520:
3510:
3415:
3302:
3100:
3095:
3085:
2993:
2983:
2968:
2943:
2938:
2928:
2923:
2918:
1867:
Jedsadayanmata A, Chen CC, Kireeva ML, Lau LF, Lam SC (August 1999).
1376:
1347:
1315:
1306:, and the CT domain interacts with members of the TGF-β superfamily,
901:
293:
280:
192:
179:
81:
1533:
1242:). CTGF has important roles in many biological processes, including
5574:
5293:
4950:
4550:
4540:
4520:
4263:
4253:
3600:
3080:
3023:
2933:
2893:
1371:
1363:
1311:
1299:
1271:
1187:
4455:
4424:
4393:
4357:
1621:"Functions and mechanisms of action of CCN matricellular proteins"
1367:
5549:
4970:
4435:
3837:
2798:
2207:
1915:
1235:
1013:
968:
886:
882:
61:
5462:
5126:
5015:
4940:
4645:
4640:
4064:
4059:
4013:
4009:
4005:
4001:
3997:
3993:
3989:
3641:
3180:
2858:
1259:
1171:
923:
501:
2512:"CCN2 is required for bleomycin-induced skin fibrosis in mice"
1670:"The CCN family of proteins: structure-function relationships"
5494:
5490:
5486:
5482:
5478:
5474:
5470:
5466:
5181:
5080:
4755:
4695:
4509:
4232:
4228:
4224:
4220:
3711:
3575:
3494:
3490:
3389:
3385:
3381:
3377:
3286:
3282:
3133:
1411:
1323:
2550:
1866:
4965:
3571:
3567:
3563:
3559:
3555:
3551:
3486:
3482:
3478:
3474:
3470:
3373:
3369:
3361:
3357:
3353:
3349:
3345:
3341:
3337:
3278:
3274:
3270:
3266:
3262:
3258:
3254:
3206:
3202:
3198:
3164:
3129:
3110:
2082:
1303:
2416:
2460:
827:
transcription initiation from RNA polymerase II promoter
317:
2158:
2117:
5565:
Pituitary adenylate cyclase-activating peptide (PACAP)
2510:
Liu S, Shi-wen X, Abraham DJ, Leask A (January 2011).
2509:
2266:
1366:
pathology. It is thought that CTGF can cooperate with
2697:
1997:
1667:
482:
1763:"The role of CCN2 in cartilage and bone development"
787:
positive regulation of cell population proliferation
637:
positive regulation of collagen biosynthetic process
2315:
747:
fibroblast growth factor receptor signaling pathway
5511:Glucose-6-phosphate isomerase (GPI; PGI, PHI, AMF)
4369:Glial cell line-derived neurotrophic factor (GDNF)
4022:Cleavage products/derivatives with unknown target:
1668:Holbourn KP, Acharya KR, Perbal B (October 2008).
1572:"Roles for CCN2 in normal physiological processes"
1452:
1450:
1448:
1431:
1429:
1427:
2363:
2361:
1565:
1563:
1561:
1265:
807:positive regulation of cardiac muscle contraction
264:
163:
5613:
5545:Macrophage-stimulating protein (MSP; HLP, HGFLP)
2038:
3186:Heparin-binding EGF-like growth factor (HB-EGF)
2869:Heparin-binding EGF-like growth factor (HB-EGF)
2039:Wahab NA, Weston BS, Mason RM (February 2005).
1569:
1445:
1424:
2358:
1760:
1715:
1713:
1558:
1511:
1509:
1507:
1505:
1457:GRCm38: Ensembl release 89: ENSMUSG00000019997
817:positive regulation of protein phosphorylation
5597:Additional growth factor receptor modulators:
2683:
1278:) domain, the von Willebrand type C repeats (
3951:Insulin-like growth factor-2 (somatomedin A)
3833:Insulin-like growth factor-2 (somatomedin A)
3823:Insulin-like growth factor-1 (somatomedin C)
2588:
2503:
2454:
2410:
2367:
2309:
2260:
2201:
2152:
2111:
2076:
2032:
1991:
1956:
1950:
1909:
1860:
1809:
1803:
1754:
1719:
847:positive regulation of stress fiber assembly
812:positive regulation of ERK1 and ERK2 cascade
1710:
1661:
1612:
1502:
1436:GRCh38: Ensembl release 89: ENSG00000118523
797:positive regulation of cell differentiation
2690:
2676:
722:positive regulation of G0 to G1 transition
707:extracellular matrix constituent secretion
2622:
2612:
2527:
2486:
2393:
2341:
2292:
2243:
2233:
2184:
2135:
2059:
2015:
1974:
1933:
1892:
1843:
1786:
1737:
1693:
1644:
1595:
1541:
872:regulation of signaling receptor activity
742:reactive oxygen species metabolic process
652:regulation of chondrocyte differentiation
5555:Migration-stimulating factor (MSF; PRG4)
1810:Babic AM, Chen CC, Lau LF (April 1999).
1353:
1342:development, and is critical for normal
621:collagen-containing extracellular matrix
2884:Transforming growth factor alpha (TGFα)
1618:
1570:Hall-Glenn F, Lyons KM (October 2011).
5614:
5458:Connective tissue growth factor (CTGF)
2594:
1515:
1329:
757:positive regulation of gene expression
737:negative regulation of gene expression
642:positive regulation of cell activation
5521:Hepatoma-derived growth factor (HDGF)
2671:
1720:Leask A, Abraham DJ (December 2006).
269:
230:
225:
168:
127:
122:
1761:Kubota S, Takigawa M (August 2011).
1240:CCN intercellular signaling protein
822:integrin-mediated signaling pathway
702:response to organic cyclic compound
13:
1957:Gao R, Brigstock DR (March 2004).
727:positive regulation of JNK cascade
540:insulin-like growth factor binding
14:
5643:
2642:
867:negative regulation of cell death
692:positive regulation of cell death
672:intracellular signal transduction
5540:Leukemia inhibitory factor (LIF)
1516:Jun JI, Lau LF (December 2011).
1302:, the TSR domain interacts with
491:
253:
246:
240:
217:
152:
145:
139:
114:
4708:Negative allosteric modulators:
2544:
1224:connective tissue growth factor
606:perinuclear region of cytoplasm
5026:Gossypetin (3,5,7,8,3',4'-HHF)
4217:Platelet-derived growth factor
1619:Chen CC, Lau LF (April 2009).
1484:
1466:
1266:Structure and binding partners
502:More reference expression data
471:More reference expression data
1:
5232:Placental growth factor (PGF)
1418:
1292:heparan sulfate proteoglycans
762:connective tissue development
677:response to mineralocorticoid
421:tunica media of zone of aorta
238:
137:
5516:Glia maturation factor (GMF)
4025:Glypromate (GPE, (1-3)IGF-1)
2235:10.1371/journal.pone.0030562
1637:10.1016/j.biocel.2008.07.025
1238:-binding proteins (see also
7:
5622:Genes on human chromosome 6
2368:Brigstock DR (March 2010).
1400:
717:response to peptide hormone
10:
5648:
5448:Colony-stimulating factors
5440:Additional growth factors:
2660:gene details page in the
1686:10.1016/j.tibs.2008.07.006
1625:Int. J. Biochem. Cell Biol
545:protein C-terminus binding
5432:
5219:
5114:
4883:
4796:SNA-120 (pegylated K252a)
4623:
4614:
4594:
4508:
4485:
4454:
4423:
4392:
4356:
4347:
4199:
4042:
3975:
3968:(against IGF-1 and IGF-2)
3937:
3930:(against IGF-1 and IGF-2)
3804:
3795:
3613:
3590:
3530:
3449:
3316:
3233:
3224:
3163:
3109:
3022:
2826:
2817:
2786:
2708:
2386:10.1007/s12079-009-0071-5
1935:10.1182/blood.V99.12.4457
1779:10.1007/s12079-011-0123-5
1588:10.1007/s00018-011-0782-7
1492:"Mouse PubMed Reference:"
1474:"Human PubMed Reference:"
1202:
1197:
1193:
1186:
1170:
1157:Chr 6: 131.95 – 131.95 Mb
1151:
1136:
1132:
1115:
1111:
1104:
1089:
1085:
1068:
1064:
1057:
1044:
1040:
1025:
1021:
1012:
999:
995:
980:
976:
967:
954:
950:
935:
931:
922:
907:
900:
896:
880:
792:chondrocyte proliferation
772:regulation of cell growth
520:
516:
499:
490:
481:
468:
417:
408:
387:Descending thoracic aorta
355:
346:
316:
308:
304:
287:
274:
237:
216:
207:
203:
186:
173:
136:
113:
104:
100:
55:
52:
42:
35:
30:
26:
21:
3632:Hepatocyte growth factor
3191:Neuregulins (heregulins)
3122:Neuregulins (heregulins)
3066:Trastuzumab duocarmazine
2779:(against angiopoietin 2)
2773:(against angiopoietin 3)
2614:10.3389/fpsyt.2019.00876
1894:10.1074/jbc.274.34.24321
1379:-induced skin fibrosis.
1358:CTGF is associated with
1164:Chr 10: 24.47 – 24.47 Mb
687:DNA biosynthetic process
395:tendon of biceps brachii
2979:Depatuxizumab mafodotin
2601:Frontiers in Psychiatry
16:Protein found in humans
5602:(neurotrophin mixture)
5590:Wnt signaling proteins
5271:Allosteric modulators:
4991:Norwogonin (5,7,8-THF)
3211:5 (tomoregulin, TMEFF)
3061:Trastuzumab deruxtecan
2699:Growth factor receptor
2137:10.1074/jbc.M201674200
2061:10.1681/ASN.2003100905
2017:10.1074/jbc.M105180200
1976:10.1074/jbc.M313204200
842:cartilage condensation
682:response to fatty acid
657:response to amino acid
555:growth factor activity
271:10 A4|10 11.84 cM
5530:T-cell growth factors
3787:Telisotuzumab vedotin
3071:Trastuzumab emtansine
2595:Davies W (Nov 2019).
2566:10.1515/cclm.2011.881
1836:10.1128/mcb.19.4.2958
1354:Clinical significance
1230:of the CCN family of
1228:matricellular protein
802:epidermis development
662:response to estradiol
425:stroma of bone marrow
379:right coronary artery
232:Chromosome 10 (mouse)
4115:EVT-901 (SAR-127963)
3848:Mecasermin rinfabate
2654:genome location and
2554:Clin. Chem. Lab. Med
2374:J Cell Commun Signal
2334:10.1210/me.2011-1045
2285:10.1210/me.2008-0045
1767:J Cell Commun Signal
1384:diabetic nephropathy
1370:to induce sustained
1340:pancreatic beta cell
1232:extracellular matrix
832:cell-matrix adhesion
767:response to wounding
647:cell differentiation
616:extracellular matrix
596:extracellular region
445:skin of external ear
391:left coronary artery
371:smooth muscle tissue
130:Chromosome 6 (human)
2662:UCSC Genome Browser
2226:2012PLoSO...730562H
2048:J. Am. Soc. Nephrol
1674:Trends Biochem. Sci
1576:Cell. Mol. Life Sci
1522:Nat Rev Drug Discov
1330:Role in development
862:cell-cell signaling
732:response to glucose
611:extracellular space
535:fibronectin binding
5281:Kinase inhibitors:
5144:Kinase inhibitors:
5043:Kinase inhibitors:
4718:Kinase inhibitors:
4533:Kinase inhibitors:
4493:Kinase inhibitors:
4474:Kinase inhibitors:
4443:Kinase inhibitors:
4412:Kinase inhibitors:
4381:Kinase inhibitors:
4241:Kinase inhibitors:
3855:Kinase inhibitors:
3649:Kinase inhibitors:
3438:Kinase inhibitors:
3431:Aprutumab ixadotin
3078:Kinase inhibitors:
2891:Kinase inhibitors:
2748:Kinase inhibitors:
2097:10.1042/BJ20081991
1732:(Pt 23): 4803–10.
1362:and virtually all
1288:integrin receptors
1002:ENSMUSG00000019997
782:tissue homeostasis
667:response to anoxia
630:Biological process
574:Cellular component
528:Molecular function
457:epithelium of lens
5609:
5608:
5215:
5214:
4976:N-Acetylserotonin
4875:ReN-1820 (TrkAd5)
4504:
4503:
4038:
4037:
3983:Binding proteins:
3642:Dihexa (PNB-0408)
3609:
3608:
3220:
3219:
3134:6 (neuroglycan C)
2854:EGF (urogastrone)
2832:
2529:10.1002/art.30074
2479:10.1002/art.27382
2177:10.1242/dev.00505
1739:10.1242/jcs.03270
1407:Ctgf/hcs24 CAESAR
1392:pancreatic cancer
1213:
1212:
1209:
1208:
1182:
1181:
1147:
1146:
1126:
1125:
1100:
1099:
1079:
1078:
1053:
1052:
1034:
1033:
1008:
1007:
989:
988:
963:
962:
944:
943:
892:
891:
586:cis-Golgi network
512:
511:
508:
507:
477:
476:
464:
463:
402:
401:
300:
299:
199:
198:
5639:
5421:Decoy receptors:
5394:Alacizumab pegol
4872:Decoy receptors:
4621:
4620:
4526:Stem cell factor
4467:Persephin (PSPN)
4405:Neurturin (NRTN)
4354:
4353:
4191:LEVI-04 (p75-Fc)
4188:Decoy receptors:
3802:
3801:
3231:
3230:
2830:
2824:
2823:
2692:
2685:
2678:
2669:
2668:
2637:
2636:
2626:
2616:
2592:
2586:
2585:
2548:
2542:
2541:
2531:
2507:
2501:
2500:
2490:
2458:
2452:
2451:
2420:J. Cell. Physiol
2414:
2408:
2407:
2397:
2365:
2356:
2355:
2345:
2313:
2307:
2306:
2296:
2264:
2258:
2257:
2247:
2237:
2205:
2199:
2198:
2188:
2156:
2150:
2149:
2139:
2130:(39): 36288–95.
2115:
2109:
2108:
2080:
2074:
2073:
2063:
2045:
2036:
2030:
2029:
2019:
2010:(44): 40659–67.
1995:
1989:
1988:
1978:
1954:
1948:
1947:
1937:
1913:
1907:
1906:
1896:
1864:
1858:
1857:
1847:
1807:
1801:
1800:
1790:
1758:
1752:
1751:
1741:
1717:
1708:
1707:
1697:
1665:
1659:
1658:
1648:
1616:
1610:
1609:
1599:
1567:
1556:
1555:
1545:
1513:
1500:
1499:
1488:
1482:
1481:
1470:
1464:
1454:
1443:
1433:
1346:development and
1344:ovarian follicle
1336:chondrodysplasia
1290:, cell surface
1218:, also known as
1195:
1194:
1166:
1159:
1142:
1130:
1129:
1121:
1109:
1108:
1105:RefSeq (protein)
1095:
1083:
1082:
1074:
1062:
1061:
1038:
1037:
1019:
1018:
993:
992:
974:
973:
948:
947:
929:
928:
898:
897:
712:lung development
560:integrin binding
518:
517:
504:
495:
488:
487:
473:
433:semi-lunar valve
413:
411:Top expressed in
406:
405:
351:
349:Top expressed in
344:
343:
323:
322:
306:
305:
296:
283:
272:
257:
250:
244:
233:
221:
205:
204:
195:
182:
171:
156:
149:
143:
132:
118:
102:
101:
96:
94:CCN2 - orthologs
47:
40:
19:
18:
5647:
5646:
5642:
5641:
5640:
5638:
5637:
5636:
5612:
5611:
5610:
5605:
5550:Midkine (NEGF2)
5428:
5211:
5110:
4879:
4817:ABT-110 (PG110)
4610:
4590:
4500:
4481:
4450:
4419:
4388:
4343:
4195:
4133:ABT-110 (PG110)
4034:
3971:
3933:
3791:
3605:
3586:
3526:
3523:(against FGF23)
3445:
3312:
3216:
3159:
3105:
3018:
2829:
2813:
2782:
2704:
2696:
2645:
2640:
2593:
2589:
2549:
2545:
2516:Arthritis Rheum
2508:
2504:
2467:Arthritis Rheum
2459:
2455:
2415:
2411:
2366:
2359:
2328:(10): 1740–59.
2322:Mol. Endocrinol
2314:
2310:
2273:Mol. Endocrinol
2265:
2261:
2206:
2202:
2171:(12): 2779–91.
2157:
2153:
2116:
2112:
2081:
2077:
2043:
2037:
2033:
1996:
1992:
1969:(10): 8848–55.
1955:
1951:
1928:(12): 4457–65.
1914:
1910:
1887:(34): 24321–7.
1876:
1872:
1865:
1861:
1824:Mol. Cell. Biol
1819:
1815:
1808:
1804:
1759:
1755:
1718:
1711:
1666:
1662:
1617:
1613:
1582:(19): 3209–17.
1568:
1559:
1534:10.1038/nrd3599
1514:
1503:
1490:
1489:
1485:
1472:
1471:
1467:
1455:
1446:
1434:
1425:
1421:
1403:
1356:
1332:
1268:
1204:View/Edit Mouse
1199:View/Edit Human
1162:
1155:
1152:Location (UCSC)
1138:
1117:
1091:
1070:
983:ENSG00000118523
876:
625:
591:plasma membrane
569:
565:heparin binding
550:protein binding
500:
469:
460:
455:
451:
447:
443:
439:
435:
431:
429:ascending aorta
427:
423:
409:
398:
393:
389:
385:
381:
377:
373:
369:
367:ascending aorta
365:
361:
347:
291:
278:
270:
260:
259:
258:
251:
231:
208:Gene location (
190:
177:
169:
159:
158:
157:
150:
128:
105:Gene location (
56:
43:
36:
17:
12:
11:
5:
5645:
5635:
5634:
5629:
5627:Growth factors
5624:
5607:
5606:
5604:
5603:
5593:
5592:
5587:
5580:Thrombopoietin
5577:
5572:
5567:
5562:
5557:
5552:
5547:
5542:
5537:
5523:
5518:
5513:
5508:
5501:Erythropoietin
5498:
5460:
5455:
5445:
5443:Adrenomedullin
5436:
5434:
5430:
5429:
5427:
5426:
5417:
5416:
5411:
5406:
5401:
5396:
5387:
5386:
5381:
5376:
5371:
5366:
5361:
5356:
5351:
5346:
5341:
5336:
5331:
5326:
5321:
5316:
5311:
5306:
5301:
5296:
5291:
5286:
5277:
5276:
5267:
5266:
5244:
5239:
5234:
5225:
5223:
5217:
5216:
5213:
5212:
5210:
5209:
5204:
5199:
5194:
5189:
5184:
5179:
5174:
5169:
5164:
5159:
5154:
5149:
5140:
5139:
5134:
5129:
5120:
5118:
5112:
5111:
5109:
5108:
5103:
5098:
5093:
5088:
5083:
5078:
5073:
5068:
5063:
5058:
5053:
5048:
5039:
5038:
5029:
5028:
5023:
5018:
5009:
5008:
5003:
4998:
4993:
4988:
4983:
4978:
4973:
4968:
4963:
4958:
4953:
4948:
4943:
4938:
4933:
4928:
4923:
4918:
4913:
4908:
4906:4'-DMA-7,8-DHF
4903:
4898:
4889:
4887:
4881:
4880:
4878:
4877:
4868:
4867:
4855:
4854:
4849:
4844:
4839:
4834:
4829:
4824:
4819:
4800:
4799:
4793:
4788:
4783:
4778:
4773:
4768:
4763:
4758:
4753:
4748:
4743:
4738:
4733:
4728:
4723:
4714:
4713:
4704:
4703:
4698:
4693:
4688:
4679:
4678:
4673:
4668:
4666:Gambogic amide
4663:
4658:
4653:
4648:
4643:
4638:
4629:
4627:
4618:
4612:
4611:
4609:
4608:
4600:
4598:
4592:
4591:
4589:
4588:
4583:
4578:
4573:
4568:
4563:
4558:
4553:
4548:
4543:
4538:
4529:
4528:
4523:
4514:
4512:
4506:
4505:
4502:
4501:
4499:
4498:
4489:
4487:
4483:
4482:
4480:
4479:
4470:
4469:
4460:
4458:
4452:
4451:
4449:
4448:
4439:
4438:
4436:Artemin (ARTN)
4429:
4427:
4421:
4420:
4418:
4417:
4408:
4407:
4398:
4396:
4390:
4389:
4387:
4386:
4377:
4376:
4371:
4362:
4360:
4351:
4345:
4344:
4342:
4341:
4336:
4331:
4322:
4321:
4316:
4311:
4306:
4301:
4296:
4291:
4286:
4281:
4276:
4271:
4266:
4261:
4256:
4251:
4246:
4237:
4236:
4214:
4205:
4203:
4197:
4196:
4194:
4193:
4184:
4183:
4171:
4170:
4165:
4160:
4155:
4150:
4145:
4140:
4135:
4123:
4122:
4117:
4112:
4107:
4098:
4097:
4092:
4087:
4082:
4077:
4072:
4067:
4062:
4057:
4048:
4046:
4040:
4039:
4036:
4035:
4033:
4032:
4027:
4018:
4017:
3979:
3977:
3973:
3972:
3970:
3969:
3963:
3954:
3953:
3943:
3941:
3935:
3934:
3932:
3931:
3925:
3920:
3915:
3910:
3905:
3900:
3895:
3890:
3881:
3880:
3875:
3870:
3865:
3860:
3851:
3850:
3845:
3840:
3835:
3830:
3825:
3820:
3810:
3808:
3799:
3793:
3792:
3790:
3789:
3784:
3779:
3774:
3769:
3764:
3759:
3750:
3749:
3744:
3739:
3734:
3729:
3724:
3719:
3714:
3709:
3704:
3699:
3694:
3689:
3684:
3679:
3674:
3669:
3664:
3659:
3654:
3645:
3644:
3635:
3634:
3629:
3619:
3617:
3611:
3610:
3607:
3606:
3604:
3603:
3594:
3592:
3588:
3587:
3585:
3584:
3579:
3545:
3536:
3534:
3528:
3527:
3525:
3524:
3514:
3513:
3508:
3503:
3498:
3464:
3455:
3453:
3447:
3446:
3444:
3443:
3434:
3433:
3428:
3419:
3418:
3413:
3408:
3403:
3398:
3393:
3331:
3322:
3320:
3314:
3313:
3311:
3310:
3305:
3300:
3295:
3290:
3248:
3239:
3237:
3228:
3222:
3221:
3218:
3217:
3215:
3214:
3188:
3183:
3178:
3169:
3167:
3161:
3160:
3158:
3157:
3152:
3147:
3138:
3137:
3115:
3113:
3107:
3106:
3104:
3103:
3098:
3093:
3088:
3083:
3074:
3073:
3068:
3063:
3058:
3053:
3048:
3039:
3038:
3028:
3026:
3020:
3019:
3017:
3016:
3011:
3006:
3001:
2996:
2991:
2986:
2981:
2976:
2971:
2962:
2961:
2956:
2951:
2946:
2941:
2936:
2931:
2926:
2921:
2916:
2911:
2906:
2901:
2896:
2887:
2886:
2881:
2876:
2871:
2866:
2861:
2856:
2851:
2846:
2836:
2834:
2821:
2815:
2814:
2812:
2811:
2806:
2801:
2792:
2790:
2784:
2783:
2781:
2780:
2774:
2764:
2763:
2758:
2753:
2744:
2743:
2741:Angiopoietin 3
2738:
2736:Angiopoietin 2
2729:
2728:
2726:Angiopoietin 4
2723:
2721:Angiopoietin 1
2714:
2712:
2706:
2705:
2695:
2694:
2687:
2680:
2672:
2666:
2665:
2644:
2643:External links
2641:
2639:
2638:
2587:
2543:
2502:
2473:(5): 1523–32.
2453:
2409:
2357:
2308:
2259:
2200:
2151:
2110:
2075:
2031:
1990:
1949:
1908:
1874:
1870:
1859:
1830:(4): 2958–66.
1817:
1813:
1802:
1753:
1709:
1680:(10): 461–73.
1660:
1611:
1557:
1528:(12): 945–63.
1501:
1483:
1465:
1444:
1422:
1420:
1417:
1416:
1415:
1409:
1402:
1399:
1355:
1352:
1331:
1328:
1267:
1264:
1211:
1210:
1207:
1206:
1201:
1191:
1190:
1184:
1183:
1180:
1179:
1177:
1175:
1168:
1167:
1160:
1153:
1149:
1148:
1145:
1144:
1134:
1133:
1127:
1124:
1123:
1113:
1112:
1106:
1102:
1101:
1098:
1097:
1087:
1086:
1080:
1077:
1076:
1066:
1065:
1059:
1055:
1054:
1051:
1050:
1042:
1041:
1035:
1032:
1031:
1023:
1022:
1016:
1010:
1009:
1006:
1005:
997:
996:
990:
987:
986:
978:
977:
971:
965:
964:
961:
960:
952:
951:
945:
942:
941:
933:
932:
926:
920:
919:
914:
909:
905:
904:
894:
893:
890:
889:
878:
877:
875:
874:
869:
864:
859:
854:
849:
844:
839:
837:cell migration
834:
829:
824:
819:
814:
809:
804:
799:
794:
789:
784:
779:
774:
769:
764:
759:
754:
749:
744:
739:
734:
729:
724:
719:
714:
709:
704:
699:
694:
689:
684:
679:
674:
669:
664:
659:
654:
649:
644:
639:
633:
631:
627:
626:
624:
623:
618:
613:
608:
603:
598:
593:
588:
583:
577:
575:
571:
570:
568:
567:
562:
557:
552:
547:
542:
537:
531:
529:
525:
524:
514:
513:
510:
509:
506:
505:
497:
496:
485:
479:
478:
475:
474:
466:
465:
462:
461:
459:
458:
454:
450:
446:
442:
438:
434:
430:
426:
422:
418:
415:
414:
403:
400:
399:
397:
396:
392:
388:
384:
380:
376:
375:gastric mucosa
372:
368:
364:
363:thoracic aorta
360:
356:
353:
352:
340:
339:
331:
320:
314:
313:
310:RNA expression
302:
301:
298:
297:
289:
285:
284:
276:
273:
268:
262:
261:
252:
245:
239:
235:
234:
229:
223:
222:
214:
213:
201:
200:
197:
196:
188:
184:
183:
175:
172:
167:
161:
160:
151:
144:
138:
134:
133:
126:
120:
119:
111:
110:
98:
97:
54:
50:
49:
41:
33:
32:
28:
27:
24:
23:
15:
9:
6:
4:
3:
2:
5644:
5633:
5630:
5628:
5625:
5623:
5620:
5619:
5617:
5601:
5598:
5595:
5594:
5591:
5588:
5585:
5581:
5578:
5576:
5573:
5571:
5568:
5566:
5563:
5561:
5558:
5556:
5553:
5551:
5548:
5546:
5543:
5541:
5538:
5535:
5531:
5527:
5524:
5522:
5519:
5517:
5514:
5512:
5509:
5506:
5502:
5499:
5496:
5492:
5488:
5484:
5480:
5476:
5472:
5468:
5464:
5461:
5459:
5456:
5453:
5449:
5446:
5444:
5441:
5438:
5437:
5435:
5431:
5425:
5422:
5419:
5418:
5415:
5412:
5410:
5407:
5405:
5402:
5400:
5397:
5395:
5392:
5389:
5388:
5385:
5382:
5380:
5377:
5375:
5372:
5370:
5367:
5365:
5362:
5360:
5357:
5355:
5352:
5350:
5347:
5345:
5342:
5340:
5337:
5335:
5332:
5330:
5327:
5325:
5322:
5320:
5317:
5315:
5312:
5310:
5307:
5305:
5302:
5300:
5297:
5295:
5292:
5290:
5287:
5285:
5282:
5279:
5278:
5275:
5274:Cyclotraxin B
5272:
5269:
5268:
5264:
5260:
5256:
5252:
5248:
5245:
5243:
5240:
5238:
5235:
5233:
5230:
5227:
5226:
5224:
5222:
5218:
5208:
5205:
5203:
5200:
5198:
5195:
5193:
5190:
5188:
5187:Larotrectinib
5185:
5183:
5180:
5178:
5175:
5173:
5170:
5168:
5165:
5163:
5160:
5158:
5155:
5153:
5150:
5148:
5145:
5142:
5141:
5138:
5135:
5133:
5130:
5128:
5125:
5122:
5121:
5119:
5117:
5113:
5107:
5104:
5102:
5099:
5097:
5094:
5092:
5089:
5087:
5086:Larotrectinib
5084:
5082:
5079:
5077:
5074:
5072:
5069:
5067:
5064:
5062:
5059:
5057:
5054:
5052:
5049:
5047:
5044:
5041:
5040:
5037:
5034:
5031:
5030:
5027:
5024:
5022:
5021:Cyclotraxin B
5019:
5017:
5014:
5011:
5010:
5007:
5004:
5002:
4999:
4997:
4994:
4992:
4989:
4987:
4984:
4982:
4979:
4977:
4974:
4972:
4969:
4967:
4964:
4962:
4959:
4957:
4954:
4952:
4949:
4947:
4944:
4942:
4939:
4937:
4934:
4932:
4931:Amitriptyline
4929:
4927:
4924:
4922:
4919:
4917:
4914:
4912:
4909:
4907:
4904:
4902:
4899:
4897:
4894:
4891:
4890:
4888:
4886:
4882:
4876:
4873:
4870:
4869:
4866:
4863:
4860:
4857:
4856:
4853:
4850:
4848:
4845:
4843:
4840:
4838:
4835:
4833:
4830:
4828:
4825:
4823:
4820:
4818:
4815:
4811:
4808:
4807:Against TrkA:
4805:
4802:
4801:
4797:
4794:
4792:
4789:
4787:
4784:
4782:
4779:
4777:
4774:
4772:
4769:
4767:
4764:
4762:
4761:Larotrectinib
4759:
4757:
4754:
4752:
4749:
4747:
4744:
4742:
4739:
4737:
4734:
4732:
4729:
4727:
4724:
4722:
4719:
4716:
4715:
4712:
4709:
4706:
4705:
4702:
4699:
4697:
4694:
4692:
4691:Dexamethasone
4689:
4687:
4684:
4681:
4680:
4677:
4674:
4672:
4669:
4667:
4664:
4662:
4659:
4657:
4654:
4652:
4649:
4647:
4644:
4642:
4639:
4637:
4636:Amitriptyline
4634:
4631:
4630:
4628:
4626:
4622:
4619:
4617:
4613:
4606:
4602:
4601:
4599:
4597:
4593:
4587:
4584:
4582:
4579:
4577:
4574:
4572:
4569:
4567:
4564:
4562:
4559:
4557:
4554:
4552:
4549:
4547:
4544:
4542:
4539:
4537:
4534:
4531:
4530:
4527:
4524:
4522:
4519:
4516:
4515:
4513:
4511:
4507:
4497:
4494:
4491:
4490:
4488:
4484:
4478:
4475:
4472:
4471:
4468:
4465:
4462:
4461:
4459:
4457:
4453:
4447:
4444:
4441:
4440:
4437:
4434:
4431:
4430:
4428:
4426:
4422:
4416:
4413:
4410:
4409:
4406:
4403:
4400:
4399:
4397:
4395:
4391:
4385:
4382:
4379:
4378:
4375:
4372:
4370:
4367:
4364:
4363:
4361:
4359:
4355:
4352:
4350:
4346:
4340:
4337:
4335:
4332:
4330:
4327:
4324:
4323:
4320:
4317:
4315:
4312:
4310:
4307:
4305:
4302:
4300:
4297:
4295:
4292:
4290:
4287:
4285:
4282:
4280:
4277:
4275:
4272:
4270:
4267:
4265:
4262:
4260:
4257:
4255:
4252:
4250:
4247:
4245:
4242:
4239:
4238:
4234:
4230:
4226:
4222:
4218:
4215:
4213:
4210:
4207:
4206:
4204:
4202:
4198:
4192:
4189:
4186:
4185:
4182:
4179:
4176:
4173:
4172:
4169:
4166:
4164:
4161:
4159:
4156:
4154:
4151:
4149:
4146:
4144:
4141:
4139:
4136:
4134:
4131:
4128:
4125:
4124:
4121:
4118:
4116:
4113:
4111:
4110:Dexamethasone
4108:
4106:
4103:
4100:
4099:
4096:
4093:
4091:
4088:
4086:
4083:
4081:
4078:
4076:
4073:
4071:
4068:
4066:
4063:
4061:
4058:
4056:
4053:
4050:
4049:
4047:
4045:
4041:
4031:
4028:
4026:
4023:
4020:
4019:
4015:
4011:
4007:
4003:
3999:
3995:
3991:
3987:
3984:
3981:
3980:
3978:
3974:
3967:
3964:
3962:
3959:
3956:
3955:
3952:
3948:
3945:
3944:
3942:
3940:
3936:
3929:
3926:
3924:
3921:
3919:
3916:
3914:
3911:
3909:
3906:
3904:
3901:
3899:
3896:
3894:
3891:
3889:
3886:
3883:
3882:
3879:
3876:
3874:
3871:
3869:
3866:
3864:
3861:
3859:
3856:
3853:
3852:
3849:
3846:
3844:
3841:
3839:
3836:
3834:
3831:
3829:
3826:
3824:
3821:
3819:
3818:des(1-3)IGF-1
3815:
3812:
3811:
3809:
3807:
3803:
3800:
3798:
3794:
3788:
3785:
3783:
3782:Telisotuzumab
3780:
3778:
3775:
3773:
3770:
3768:
3765:
3763:
3760:
3758:
3755:
3752:
3751:
3748:
3745:
3743:
3740:
3738:
3735:
3733:
3730:
3728:
3725:
3723:
3720:
3718:
3715:
3713:
3710:
3708:
3705:
3703:
3700:
3698:
3695:
3693:
3690:
3688:
3685:
3683:
3680:
3678:
3675:
3673:
3670:
3668:
3665:
3663:
3660:
3658:
3655:
3653:
3650:
3647:
3646:
3643:
3640:
3639:Potentiators:
3637:
3636:
3633:
3630:
3628:
3624:
3621:
3620:
3618:
3616:
3612:
3602:
3599:
3596:
3595:
3593:
3589:
3583:
3580:
3577:
3573:
3569:
3565:
3561:
3557:
3553:
3549:
3546:
3544:
3541:
3538:
3537:
3535:
3533:
3529:
3522:
3519:
3516:
3515:
3512:
3509:
3507:
3504:
3502:
3501:Selpercatinib
3499:
3496:
3492:
3488:
3484:
3480:
3476:
3472:
3468:
3465:
3463:
3460:
3457:
3456:
3454:
3452:
3448:
3442:
3439:
3436:
3435:
3432:
3429:
3427:
3424:
3421:
3420:
3417:
3414:
3412:
3409:
3407:
3406:Selpercatinib
3404:
3402:
3399:
3397:
3394:
3391:
3387:
3383:
3379:
3375:
3371:
3367:
3363:
3359:
3355:
3351:
3347:
3343:
3339:
3335:
3332:
3330:
3327:
3324:
3323:
3321:
3319:
3315:
3309:
3306:
3304:
3301:
3299:
3298:Selpercatinib
3296:
3294:
3291:
3288:
3284:
3280:
3276:
3272:
3268:
3264:
3260:
3256:
3252:
3249:
3247:
3244:
3241:
3240:
3238:
3236:
3232:
3229:
3227:
3223:
3212:
3208:
3204:
3200:
3196:
3192:
3189:
3187:
3184:
3182:
3179:
3177:
3174:
3171:
3170:
3168:
3166:
3162:
3156:
3153:
3151:
3148:
3146:
3143:
3140:
3139:
3135:
3131:
3127:
3123:
3120:
3117:
3116:
3114:
3112:
3108:
3102:
3099:
3097:
3094:
3092:
3089:
3087:
3084:
3082:
3079:
3076:
3075:
3072:
3069:
3067:
3064:
3062:
3059:
3057:
3054:
3052:
3049:
3047:
3044:
3041:
3040:
3037:
3033:
3030:
3029:
3027:
3025:
3021:
3015:
3012:
3010:
3007:
3005:
3002:
3000:
2997:
2995:
2992:
2990:
2987:
2985:
2982:
2980:
2977:
2975:
2974:Depatuxizumab
2972:
2970:
2967:
2964:
2963:
2960:
2957:
2955:
2952:
2950:
2947:
2945:
2942:
2940:
2937:
2935:
2932:
2930:
2927:
2925:
2922:
2920:
2917:
2915:
2912:
2910:
2907:
2905:
2902:
2900:
2897:
2895:
2892:
2889:
2888:
2885:
2882:
2880:
2877:
2875:
2872:
2870:
2867:
2865:
2862:
2860:
2857:
2855:
2852:
2850:
2847:
2845:
2841:
2838:
2837:
2835:
2833:
2825:
2822:
2820:
2816:
2810:
2807:
2805:
2802:
2800:
2797:
2794:
2793:
2791:
2789:
2785:
2778:
2775:
2772:
2769:
2766:
2765:
2762:
2759:
2757:
2754:
2752:
2749:
2746:
2745:
2742:
2739:
2737:
2734:
2731:
2730:
2727:
2724:
2722:
2719:
2716:
2715:
2713:
2711:
2707:
2703:
2700:
2693:
2688:
2686:
2681:
2679:
2674:
2673:
2670:
2663:
2659:
2658:
2653:
2652:
2647:
2646:
2634:
2630:
2625:
2620:
2615:
2610:
2606:
2602:
2598:
2591:
2583:
2579:
2575:
2571:
2567:
2563:
2560:(1): 167–74.
2559:
2555:
2547:
2539:
2535:
2530:
2525:
2522:(1): 239–46.
2521:
2517:
2513:
2506:
2498:
2494:
2489:
2484:
2480:
2476:
2472:
2468:
2464:
2457:
2449:
2445:
2441:
2437:
2433:
2429:
2425:
2421:
2413:
2405:
2401:
2396:
2391:
2387:
2383:
2379:
2375:
2371:
2364:
2362:
2353:
2349:
2344:
2339:
2335:
2331:
2327:
2323:
2319:
2312:
2304:
2300:
2295:
2290:
2286:
2282:
2279:(3): 324–36.
2278:
2274:
2270:
2263:
2255:
2251:
2246:
2241:
2236:
2231:
2227:
2223:
2220:(2): e30562.
2219:
2215:
2211:
2204:
2196:
2192:
2187:
2182:
2178:
2174:
2170:
2166:
2162:
2155:
2147:
2143:
2138:
2133:
2129:
2125:
2124:J. Biol. Chem
2121:
2114:
2106:
2102:
2098:
2094:
2091:(3): 413–20.
2090:
2086:
2079:
2071:
2067:
2062:
2057:
2054:(2): 340–51.
2053:
2049:
2042:
2035:
2027:
2023:
2018:
2013:
2009:
2005:
2004:J. Biol. Chem
2001:
1994:
1986:
1982:
1977:
1972:
1968:
1964:
1963:J. Biol. Chem
1960:
1953:
1945:
1941:
1936:
1931:
1927:
1923:
1919:
1912:
1904:
1900:
1895:
1890:
1886:
1882:
1881:J. Biol. Chem
1878:
1863:
1855:
1851:
1846:
1841:
1837:
1833:
1829:
1825:
1821:
1806:
1798:
1794:
1789:
1784:
1780:
1776:
1773:(3): 209–17.
1772:
1768:
1764:
1757:
1749:
1745:
1740:
1735:
1731:
1727:
1723:
1716:
1714:
1705:
1701:
1696:
1691:
1687:
1683:
1679:
1675:
1671:
1664:
1656:
1652:
1647:
1642:
1638:
1634:
1631:(4): 771–83.
1630:
1626:
1622:
1615:
1607:
1603:
1598:
1593:
1589:
1585:
1581:
1577:
1573:
1566:
1564:
1562:
1553:
1549:
1544:
1539:
1535:
1531:
1527:
1523:
1519:
1512:
1510:
1508:
1506:
1497:
1493:
1487:
1479:
1475:
1469:
1462:
1458:
1453:
1451:
1449:
1441:
1437:
1432:
1430:
1428:
1423:
1413:
1410:
1408:
1405:
1404:
1398:
1395:
1393:
1389:
1385:
1380:
1378:
1373:
1369:
1365:
1361:
1360:wound healing
1351:
1349:
1345:
1341:
1337:
1327:
1325:
1321:
1317:
1313:
1309:
1305:
1301:
1297:
1293:
1289:
1285:
1284:cysteine knot
1281:
1277:
1273:
1263:
1261:
1257:
1253:
1252:proliferation
1249:
1245:
1244:cell adhesion
1241:
1237:
1233:
1229:
1225:
1221:
1217:
1205:
1200:
1196:
1192:
1189:
1185:
1178:
1176:
1173:
1169:
1165:
1161:
1158:
1154:
1150:
1143:
1141:
1135:
1131:
1128:
1122:
1120:
1114:
1110:
1107:
1103:
1096:
1094:
1088:
1084:
1081:
1075:
1073:
1067:
1063:
1060:
1058:RefSeq (mRNA)
1056:
1049:
1048:
1043:
1039:
1036:
1030:
1029:
1024:
1020:
1017:
1015:
1011:
1004:
1003:
998:
994:
991:
985:
984:
979:
975:
972:
970:
966:
959:
958:
953:
949:
946:
940:
939:
934:
930:
927:
925:
921:
918:
915:
913:
910:
906:
903:
899:
895:
888:
884:
879:
873:
870:
868:
865:
863:
860:
858:
857:cell adhesion
855:
853:
850:
848:
845:
843:
840:
838:
835:
833:
830:
828:
825:
823:
820:
818:
815:
813:
810:
808:
805:
803:
800:
798:
795:
793:
790:
788:
785:
783:
780:
778:
775:
773:
770:
768:
765:
763:
760:
758:
755:
753:
750:
748:
745:
743:
740:
738:
735:
733:
730:
728:
725:
723:
720:
718:
715:
713:
710:
708:
705:
703:
700:
698:
695:
693:
690:
688:
685:
683:
680:
678:
675:
673:
670:
668:
665:
663:
660:
658:
655:
653:
650:
648:
645:
643:
640:
638:
635:
634:
632:
629:
628:
622:
619:
617:
614:
612:
609:
607:
604:
602:
599:
597:
594:
592:
589:
587:
584:
582:
579:
578:
576:
573:
572:
566:
563:
561:
558:
556:
553:
551:
548:
546:
543:
541:
538:
536:
533:
532:
530:
527:
526:
523:
522:Gene ontology
519:
515:
503:
498:
494:
489:
486:
484:
480:
472:
467:
456:
452:
448:
444:
440:
436:
432:
428:
424:
420:
419:
416:
412:
407:
404:
394:
390:
386:
382:
378:
374:
370:
366:
362:
358:
357:
354:
350:
345:
342:
341:
338:
336:
332:
330:
329:
325:
324:
321:
319:
315:
311:
307:
303:
295:
290:
286:
282:
277:
267:
263:
256:
249:
243:
236:
228:
224:
220:
215:
211:
206:
202:
194:
189:
185:
181:
176:
166:
162:
155:
148:
142:
135:
131:
125:
121:
117:
112:
108:
103:
99:
95:
91:
87:
83:
79:
75:
71:
67:
63:
59:
51:
46:
39:
34:
29:
25:
20:
5632:CCN proteins
5600:Cerebrolysin
5596:
5570:Pleiotrophin
5526:Interleukins
5439:
5420:
5390:
5309:Fruquintinib
5299:Cabozantinib
5280:
5270:
5228:
5192:Lestaurtinib
5143:
5123:
5091:Lestaurtinib
5042:
5032:
5013:Antagonists:
5012:
4946:Deoxygedunin
4901:3,7,8,2'-THF
4892:
4871:
4862:Against NGF:
4861:
4858:
4814:Against NGF:
4813:
4806:
4803:
4766:Lestaurtinib
4717:
4707:
4701:Testosterone
4683:Antagonists:
4682:
4632:
4532:
4517:
4492:
4473:
4463:
4442:
4432:
4411:
4401:
4380:
4365:
4325:
4240:
4208:
4187:
4178:Against NGF:
4177:
4174:
4130:Against NGF:
4129:
4126:
4120:Testosterone
4102:Antagonists:
4101:
4051:
4021:
3982:
3957:
3946:
3923:Teprotumumab
3884:
3854:
3813:
3762:Ficlatuzumab
3757:Emibetuzumab
3753:
3707:JNJ-38877605
3677:Cabozantinib
3648:
3638:
3627:Fosgonimeton
3622:
3597:
3539:
3517:
3458:
3441:Infigratinib
3437:
3422:
3325:
3242:
3176:Betacellulin
3172:
3155:Seribantumab
3141:
3118:
3077:
3042:
3036:Unknown/none
3035:
3031:
2965:
2890:
2849:Betacellulin
2844:Amphiregulin
2839:
2831:(ErbB1/HER1)
2795:
2767:
2747:
2733:Antagonists:
2732:
2717:
2710:Angiopoietin
2656:
2650:
2604:
2600:
2590:
2557:
2553:
2546:
2519:
2515:
2505:
2470:
2466:
2456:
2426:(1): 153–9.
2423:
2419:
2412:
2377:
2373:
2325:
2321:
2311:
2276:
2272:
2262:
2217:
2213:
2203:
2168:
2164:
2154:
2127:
2123:
2113:
2088:
2084:
2078:
2051:
2047:
2034:
2007:
2003:
1993:
1966:
1962:
1952:
1925:
1921:
1911:
1884:
1880:
1862:
1827:
1823:
1805:
1770:
1766:
1756:
1729:
1725:
1677:
1673:
1663:
1628:
1624:
1614:
1579:
1575:
1525:
1521:
1495:
1486:
1477:
1468:
1396:
1381:
1357:
1333:
1269:
1256:angiogenesis
1234:-associated
1223:
1219:
1215:
1214:
1137:
1116:
1090:
1069:
1045:
1026:
1000:
981:
955:
936:
916:
911:
852:human ageing
777:angiogenesis
697:ossification
453:ciliary body
441:aortic valve
333:
326:
191:131,951,372
178:131,948,176
53:External IDs
5560:Oncomodulin
5424:Aflibercept
5414:Ranibizumab
5409:Ramucirumab
5399:Bevacizumab
5391:Antibodies:
5349:Regorafenib
5289:Altiratinib
5202:ONO-5390556
5172:Entrectinib
5147:Altiratinib
5101:ONO-5390556
5071:Entrectinib
5046:Altiratinib
4832:Frunevetmab
4804:Antibodies:
4781:ONO-5390556
4746:Entrectinib
4721:Altiratinib
4676:Tavilermide
4571:Quizartinib
4510:SCF (c-Kit)
4334:Ramucirumab
4326:Antibodies:
4299:Quizartinib
4249:Avapritinib
4212:Becaplermin
4148:Frunevetmab
4127:Antibodies:
4030:Trofinetide
3961:Dusigitumab
3958:Antibodies:
3913:Robatumumab
3903:Figitumumab
3898:Dalotuzumab
3893:Cixutumumab
3885:Antibodies:
3777:Rilotumumab
3772:Onartuzumab
3767:Flanvotumab
3754:Antibodies:
3722:PF-04217903
3652:Altiratinib
3615:HGF (c-Met)
3518:Antibodies:
3423:Antibodies:
3145:Duligotumab
3142:Antibodies:
3056:Trastuzumab
3046:Ertumaxomab
3043:Antibodies:
3014:Zalutumumab
3009:Panitumumab
3004:Nimotuzumab
2999:Necitumumab
2989:Imgatuzumab
2966:Antibodies:
2949:Osimertinib
2914:Dacomitinib
2809:Dapiclermin
2768:Antibodies:
2751:Altiratinib
2165:Development
1726:J. Cell Sci
1388:retinopathy
1308:fibronectin
601:cell cortex
437:ankle joint
383:gallbladder
292:24,474,581
279:24,471,340
31:Identifiers
5616:Categories
5379:Vandetanib
5344:Rebastinib
5339:Pegaptanib
5329:Nintedanib
5319:Lenvatinib
5284:Agerafenib
5237:Ripretinib
5162:CH-7057288
5061:CH-7057288
4926:7,8,3'-THF
4921:7,8,2'-THF
4847:Ranevetmab
4837:Fulranumab
4791:Rebastinib
4736:CH-7057288
4651:Cenegermin
4536:Agerafenib
4496:Agerafenib
4477:Vandetanib
4446:Vandetanib
4415:Vandetanib
4384:Vandetanib
4329:Olaratumab
4304:Ripretinib
4284:Nintedanib
4269:Lenvatinib
4259:Crenolanib
4244:Agerafenib
4163:Ranevetmab
4153:Fulranumab
4070:Cenegermin
4044:LNGF (p75)
3966:Xentuzumab
3928:Xentuzumab
3873:NVP-AEW541
3868:NVP-ADW742
3863:Linsitinib
3858:BMS-754807
3843:Mecasermin
3742:Tivantinib
3732:PHA-665752
3727:PF-2341066
3697:Golvatinib
3687:Crizotinib
3682:Capmatinib
3672:BMS-777607
3667:Amuvatinib
3543:Ersofermin
3506:Sprifermin
3462:Ersofermin
3411:Sprifermin
3401:Repifermin
3396:Palifermin
3329:Ersofermin
3308:Velafermin
3293:Repifermin
3246:Ersofermin
3165:ErbB4/HER4
3150:Patritumab
3111:ErbB3/HER3
3091:Mubritinib
3051:Pertuzumab
3024:ErbB2/HER2
2954:Vandetanib
2909:Canertinib
2904:Brigatinib
2899:Agerafenib
2879:Nepidermin
2874:Murodermin
2864:Epiregulin
2819:EGF (ErbB)
2777:Nesvacumab
2771:Evinacumab
2761:Rebastinib
2702:modulators
2380:(1): 1–4.
2085:Biochem. J
1463:, May 2017
1442:, May 2017
1419:References
337:(ortholog)
74:HomoloGene
5404:Icrucumab
5384:WHI-P 154
5374:Tivozanib
5369:Toceranib
5364:Sunitinib
5359:Sorafenib
5354:Semaxanib
5334:Pazopanib
5324:Motesanib
5314:Lapatinib
5304:Cediranib
5242:Telbermin
5229:Agonists:
5177:GZ-389988
5157:CE-245677
5124:Agonists:
5076:GZ-389988
5056:CE-245677
4956:Diosmetin
4893:Agonists:
4859:Aptamers:
4852:Tanezumab
4827:Fasinumab
4771:Milciclib
4751:GZ-389988
4731:CE-245677
4633:Agonists:
4586:Toceranib
4581:Sunitinib
4576:Sorafenib
4566:Pazopanib
4561:Nilotinib
4556:Masitinib
4546:Dasatinib
4518:Agonists:
4464:Agonists:
4433:Agonists:
4402:Agonists:
4374:Liatermin
4366:Agonists:
4349:RET (GFL)
4339:Tovetumab
4319:Toceranib
4314:Sorafenib
4309:Sunitinib
4294:Radotinib
4289:Pazopanib
4279:Motesanib
4274:Masitinib
4209:Agonists:
4175:Aptamers:
4168:Tanezumab
4143:Fasinumab
4052:Agonists:
3908:Ganitumab
3828:IGF-1 LR3
3747:Volitinib
3702:INCB28060
3692:Foretinib
3598:Agonists:
3582:Trafermin
3540:Agonists:
3521:Burosumab
3511:Trafermin
3459:Agonists:
3426:Aprutumab
3416:Trafermin
3378:10 (KGF2)
3326:Agonists:
3303:Trafermin
3283:10 (KGF2)
3243:Agonists:
3173:Agonists:
3119:Agonists:
3101:Tucatinib
3096:Neratinib
3086:Lapatinib
2994:Matuzumab
2984:Futuximab
2969:Cetuximab
2959:WHI-P 154
2944:Neratinib
2939:Lapatinib
2929:Grandinin
2924:Gefitinib
2919:Erlotinib
2796:Agonists:
2756:CE-245677
2718:Agonists:
1377:bleomycin
1348:ovulation
1316:fibulin-1
1294:(HSPGs),
1248:migration
1140:NP_034347
1119:NP_001892
1093:NM_010217
1072:NM_001901
902:Orthologs
82:GeneCards
5586:instead)
5575:Renalase
5536:instead)
5507:instead)
5454:instead)
5294:Axitinib
5263:D (FIGF)
5207:PLX-7486
5197:ONO-4474
5152:AZD-6918
5106:PLX-7486
5096:ONO-4474
5051:AZD-6918
5033:Ligands:
4951:Deprenyl
4911:7,3'-DHF
4842:MEDI-578
4822:ASP-6294
4786:PLX-7486
4776:ONO-4474
4726:AZD-6918
4686:ALE-0540
4607:instead.
4551:Imatinib
4541:Axitinib
4521:Ancestim
4486:Unsorted
4264:Imatinib
4254:Axitinib
4158:MEDI-578
4138:ASP-6294
4105:ALE-0540
3947:Agonists
3888:AVE-1642
3814:Agonists
3737:SU-11274
3623:Agonists
3601:FGF15/19
3591:Unsorted
3556:2 (bFGF)
3475:2 (bFGF)
3342:2 (bFGF)
3259:2 (bFGF)
3081:Afatinib
3032:Agonists
2934:Icotinib
2894:Afatinib
2840:Agonists
2633:31849729
2582:26045011
2574:22505539
2538:20936632
2497:20213804
2448:21284888
2440:10457363
2404:19798591
2352:21868453
2303:19131512
2254:22363445
2214:PLOS ONE
2195:12736220
2146:12114504
2105:19298220
2070:15601748
2026:11518710
1985:14684735
1944:12036876
1903:10446209
1854:10082563
1797:21484188
1748:17130294
1704:18789696
1655:18775791
1606:21858450
1552:22129992
1459:–
1438:–
1401:See also
1372:fibrosis
1364:fibrotic
1312:perlecan
1300:aggrecan
1272:cysteine
1188:Wikidata
881:Sources:
5463:Ephrins
5167:DS-6051
5066:DS-6051
4971:LM22A-4
4961:DMAQ-B1
4916:7,8-DHF
4896:3,7-DHF
4865:RBM-004
4810:GBR-900
4741:DS-6051
4711:VM-902A
4181:RBM-004
3878:OSl-906
3838:Insulin
3717:MK-2461
3662:AMG-458
2799:Axokine
2624:6901936
2607:: 876.
2488:3866029
2395:2821473
2343:3182424
2294:2654514
2245:3282727
2222:Bibcode
2186:3360973
1788:3145877
1695:2683937
1646:2668982
1597:3670951
1543:3663145
1461:Ensembl
1440:Ensembl
1260:cancers
1236:heparin
1226:, is a
1014:UniProt
969:Ensembl
908:Species
887:QuickGO
581:cytosol
312:pattern
38:Aliases
5433:Others
5127:BNN-20
5016:ANA-12
4941:BNN-20
4661:DHEA-S
4646:BNN-27
4641:BNN-20
4080:DHEA-S
4065:BNN-27
4060:BNN-20
3976:Others
3181:Epigen
2859:Epigen
2648:Human
2631:
2621:
2580:
2572:
2536:
2495:
2485:
2446:
2438:
2402:
2392:
2350:
2340:
2301:
2291:
2252:
2242:
2193:
2183:
2144:
2103:
2068:
2024:
1983:
1942:
1901:
1852:
1842:
1795:
1785:
1746:
1702:
1692:
1653:
1643:
1604:
1594:
1550:
1540:
1414:(CCN1)
1324:mucins
1322:, and
1174:search
1172:PubMed
1047:P29268
1028:P29279
924:Entrez
483:BioGPS
170:6q23.2
62:121009
5582:(see
5532:(see
5503:(see
5450:(see
5182:K252a
5081:K252a
4756:K252a
4696:FX007
4456:GFRα4
4425:GFRα3
4394:GFRα2
4358:GFRα1
3986:IGFBP
3939:IGF-2
3918:R1507
3806:IGF-1
3712:K252a
3532:FGFR4
3451:FGFR3
3318:FGFR2
3235:FGFR1
2578:S2CID
2444:S2CID
2044:(PDF)
1922:Blood
1845:84090
1412:CYR61
1368:TGF-β
1276:IGFBP
957:14219
917:Mouse
912:Human
883:Amigo
449:ankle
359:tibia
335:Mouse
328:Human
275:Start
210:Mouse
174:Start
107:Human
70:95537
5584:here
5534:here
5505:here
5452:here
5247:VEGF
5221:VEGF
5137:NT-3
5132:DHEA
5116:TrkC
5036:DHEA
5006:TDP6
4986:NT-4
4981:NT-3
4966:HIOC
4936:BDNF
4885:TrkB
4656:DHEA
4625:TrkA
4605:here
4603:See
4596:TGFβ
4201:PDGF
4095:NT-4
4090:NT-3
4075:DHEA
4055:BDNF
2804:CNTF
2788:CNTF
2657:CTGF
2651:CTGF
2629:PMID
2570:PMID
2534:PMID
2493:PMID
2436:PMID
2400:PMID
2348:PMID
2299:PMID
2250:PMID
2191:PMID
2142:PMID
2101:PMID
2066:PMID
2022:PMID
1981:PMID
1940:PMID
1899:PMID
1850:PMID
1793:PMID
1744:PMID
1700:PMID
1651:PMID
1602:PMID
1548:PMID
1386:and
1320:slit
1304:VEGF
1296:LRPs
1220:CCN2
1216:CTGF
938:1490
318:Bgee
266:Band
227:Chr.
165:Band
124:Chr.
86:CCN2
78:1431
58:OMIM
45:CCN2
22:CCN2
5001:R13
4671:NGF
4616:Trk
4085:NGF
3797:IGF
3657:AM7
3548:FGF
3467:FGF
3368:),
3366:KGF
3334:FGF
3251:FGF
3226:FGF
2828:EGF
2619:PMC
2609:doi
2562:doi
2524:doi
2483:PMC
2475:doi
2428:doi
2424:181
2390:PMC
2382:doi
2338:PMC
2330:doi
2289:PMC
2281:doi
2240:PMC
2230:doi
2181:PMC
2173:doi
2169:130
2132:doi
2128:277
2093:doi
2089:420
2056:doi
2012:doi
2008:276
1971:doi
1967:279
1930:doi
1889:doi
1885:274
1871:IIb
1840:PMC
1832:doi
1783:PMC
1775:doi
1734:doi
1730:119
1690:PMC
1682:doi
1641:PMC
1633:doi
1592:PMC
1584:doi
1538:PMC
1530:doi
1280:vWC
1222:or
288:End
187:End
90:OMA
66:MGI
5618::
5495:B3
5493:,
5491:B2
5489:,
5487:B1
5485:,
5483:A5
5481:,
5479:A4
5477:,
5475:A3
5473:,
5471:A2
5469:,
5467:A1
5261:,
5257:,
5253:,
4996:R7
4812:;
4231:,
4227:,
4223:,
4012:,
4008:,
4004:,
4000:,
3996:,
3992:,
3949::
3816::
3625::
3576:19
3574:,
3570:,
3566:,
3562:,
3558:,
3554:,
3495:23
3493:,
3491:18
3489:,
3485:,
3481:,
3477:,
3473:,
3390:22
3388:,
3386:18
3384:,
3382:17
3380:,
3376:,
3372:,
3360:,
3356:,
3352:,
3348:,
3344:,
3340:,
3287:20
3285:,
3281:,
3277:,
3273:,
3269:,
3265:,
3261:,
3257:,
3209:,
3205:,
3201:,
3197:,
3132:,
3128:,
3034::
2842::
2627:.
2617:.
2605:10
2603:.
2599:.
2576:.
2568:.
2558:50
2556:.
2532:.
2520:63
2518:.
2514:.
2491:.
2481:.
2471:62
2469:.
2465:.
2442:.
2434:.
2422:.
2398:.
2388:.
2376:.
2372:.
2360:^
2346:.
2336:.
2326:25
2324:.
2320:.
2297:.
2287:.
2277:23
2275:.
2271:.
2248:.
2238:.
2228:.
2216:.
2212:.
2189:.
2179:.
2167:.
2163:.
2140:.
2126:.
2122:.
2099:.
2087:.
2064:.
2052:16
2050:.
2046:.
2020:.
2006:.
2002:.
1979:.
1965:.
1961:.
1938:.
1926:99
1924:.
1920:.
1897:.
1883:.
1879:.
1848:.
1838:.
1828:19
1826:.
1822:.
1791:.
1781:.
1769:.
1765:.
1742:.
1728:.
1724:.
1712:^
1698:.
1688:.
1678:33
1676:.
1672:.
1649:.
1639:.
1629:41
1627:.
1623:.
1600:.
1590:.
1580:68
1578:.
1574:.
1560:^
1546:.
1536:.
1526:10
1524:.
1520:.
1504:^
1494:.
1476:.
1447:^
1426:^
1394:.
1350:.
1326:.
1318:,
1314:,
1310:,
1262:.
1254:,
1250:,
1246:,
885:/
294:bp
281:bp
193:bp
180:bp
88:;
84::
80:;
76::
72:;
68::
64:;
60::
5528:/
5497:)
5465:(
5265:)
5259:C
5255:B
5251:A
5249:(
4798:)
4235:)
4233:D
4229:C
4225:B
4221:A
4219:(
4016:)
4014:7
4010:6
4006:5
4002:4
3998:3
3994:2
3990:1
3988:(
3578:)
3572:9
3568:8
3564:6
3560:4
3552:1
3550:(
3497:)
3487:9
3483:8
3479:4
3471:1
3469:(
3392:)
3374:9
3370:8
3364:(
3362:7
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