137:"Biological Resource Centres are an essential part of the infrastructure underpinning biotechnology. They consist of service providers and repositories of the living cells, genomes of organisms, and information relating to heredity and the functions of biological systems. BRCs contain collections of culturable organisms (e.g.
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is a facility that collects, catalogs, and stores samples of biological material for laboratory research. Biorepositories collect and manage specimens from animals, plants, and other living organisms. Biorepositories store many different types of specimens, including samples of
93:(iii) Storage and inventory are where all samples are held prior to being requested via a distribution request. The inventory system is composed of sample holding boxes and the boxes are stored in freezers of various types depending on the sample storage requirements.
90:(ii) Processing of specimens is standardized to minimize variation due to handling. Processing may prepare the specimen for long-term storage. For example, DNA samples are processed into a salt buffer (aqueous solution) of proper pH to stabilize the DNA for storage.
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The purpose of a biorepository is to maintain biological specimens, and associated information, for future use in research. The biorepository maintains the quality of specimens in its collection and ensures that they are accessible for scientific research.
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Genetic
Testing Reference Material Program (GeT-RM) maintains DNA samples for use in molecular genetic testing. These samples are from diseases such as Huntington Disease, Cystic Fibrosis, Fragile X Syndrome, Alpha-Thalassemia, and Muenke
87:("LIMS"), which tracks information about all of the specimens in the biorepository. Typical information linked to a specimen would be the specimen's origin and when it arrived at the biorepository.
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The
National Institute on Aging (NIA) Aging Cell Repository facilitates research into the mechanisms of aging by providing cell lines collected from subjects of different ages.
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SOPs provide a standardized framework of how to conduct operations within a biorepository. They ensure seamless and reliable processes be implemented throughout operations.
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The
National Institute of General Medical Sciences (NIGMS) Human Genetic Cell Repository is collection of well-characterized human cells for use in biomedical research.
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The four main operations of a biorepository are; (i) collection (ii) processing, (iii) storage or inventory, and (iv) distribution of biological specimens.
63:. If the samples are from people, they may be stored with medical information along with written consent to use the samples in laboratory studies.
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Smith, D; Ryan, MJ (January 2008). "The impact of OECD best practice on the validation of cryopreservation techniques for microorganisms".
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83:(i) Collection or accession occurs when a specimen arrives at the biorepository. Information about the specimen is entered into the
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SOPs reduce variability within the samples and storage processes by providing standardized guidelines for proper storage and care.
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Biorepository is a collection of over 4.5 million biological samples preserved in formalin and embedded in paraffin wax.
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Human Cell and Data
Repository maintains a collection of cell lines to advance the study of neurological disorders.
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96:(iv) Distribution is the process of retrieving one or more samples from the biorepository inventory system.
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play a crucial role in the biorepository industry. There are a number of reasons why they are important:
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Biospecimen samples should closely resemble biospecimens in their natural state. SOPs help ensure that.
433:"A Resource for Stem Cells including iPSCs and Fibroblasts | The NINDS Human Cell and Data Repository"
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Siwek, Martina (October 2015). "An
Overview of Biorepositories—Past, Present, and Future".
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ProMedDx BioServices cGMP Biostorage & Biorepository - Biorepository
Consulting Design
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National
Institute of Allergies and Infectious Diseases HIV/AIDS Specimen Repository
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has issued best practice guidelines for biorepositories, which are referred to as
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Society for Biological and Environmental Repositories ("ISBER")
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356:"The Importance of Standard Operating Procedures (SOPS) in Biobanking"
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and structural information relevant to these collections and related
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331:"Genomic Medicine: Biobanking Standard Operating Procedures (SOPs)"
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Clinical
Specimens Database and Specimen Collections Repository
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National
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Global Directory of Biobanks, Tissue Banks and Biorepositories
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OECD Best Practice Guidelines for Biological Resource Centres
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Place in which biological materials are stored and preserved
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Cell&Co Biorepository - The first French Eco-Biobank
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Human Reference Genome makes available DNA samples from
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197:Examples of Biorepositories in the United States
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134:. They are defined by the OECD as follows:
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537:"About the Intermountain Biorepository"
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513:"NIGMS Human Genetic Cell Repository"
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105:Standard Operating Procedures (SOPs)
613:Specimen Central biorepository list
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306:"NCI Dictionaries - biorepository"
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132:biological resource centres
122:Biological Resource Centres
18:Biological Resource Centers
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475:10.7205/MILMED-D-15-00119
310:National Cancer Institute
236:J. Craig Venter Institute
229:Intermountain Healthcare
276:Genetic fingerprinting
202:Cell Line Repositories
665:Biological specimens
420:OECD BRC Guidelines
266:Biological database
222:Sample Repositories
624:Biorepository LIMS
517:www.nigms.nih.gov
463:Military Medicine
437:nindsgenetics.org
335:Inside Biobanking
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593:. Retrieved
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589:www.cdc.gov
151:human cells
659:Categories
595:2021-10-20
570:2021-10-20
546:2021-10-20
522:2021-10-20
498:2021-10-20
442:2021-10-20
365:2017-10-16
341:2017-10-16
316:2021-09-23
292:References
76:Operations
271:Gene bank
250:Syndrome.
183:molecular
171:organisms
393:18392291
286:Genotype
281:Genomics
255:See also
159:plasmids
61:proteins
561:"HuRef"
261:Biobank
179:tissues
163:viruses
155:genomes
67:Purpose
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147:animal
59:, and
45:tissue
489:"NIA"
175:cells
167:cDNAs
143:plant
49:cells
41:urine
37:blood
389:PMID
245:The
234:The
227:The
207:The
177:and
149:and
128:OECD
126:The
471:doi
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57:RNA
53:DNA
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