523:. The 51-year-old patient had strange behavioral symptoms, including a loss of short-term memory; she became his obsession over the coming years. Auguste Deter was a victim of the politics of the time in the psychiatric community; the Frankfurt asylum was too expensive for her husband. Herr Deter made several requests to have his wife moved to a less expensive facility, but Alzheimer intervened in these requests. Frau Deter, as she was known, remained at the Frankfurt asylum, where Alzheimer had made a deal to receive her records and brain upon her death, paying for the remainder of her stay in return.
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At the time, Kraepelin was doing clinical research on psychosis in senile patients; Alzheimer, on the other hand, was more interested in the lab work of senile illnesses. They faced many challenges involving the politics of the psychiatric community. For example, formal and informal arrangements were
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Following his presentation, Alzheimer published a short paper summarizing his presentation; in 1907 he wrote a longer paper detailing the disease and his findings. It became known as
Alzheimer's disease in 1910, when Kraepelin named it so in the chapter on "Presenile and Senile Dementia" in the 8th
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meeting of the
Southwest German Psychiatrists. The attendees at this lecture seemed uninterested in what he had to say. The lecturer that followed Alzheimer was to speak on the topic of "compulsive masturbation", which the audience of 88 individuals was so eagerly awaiting that they sent Alzheimer
580:
480:, one of the best-known German psychiatrists of the time. Kraepelin became a mentor to Alzheimer, and the two worked very closely for the next several years. When Kraepelin moved to Munich to work at the Royal Psychiatric Hospital in 1903, he invited Alzheimer to join him.
469:, began to work in the same asylum with Alzheimer. Together, they conducted research on the pathology of the nervous system, specifically the normal and pathological anatomy of the cerebral cortex. Alzheimer was the co-founder and co-publisher of the journal
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in 1912, where he accepted a post as professor of psychiatry and director of the
Neurologic and Psychiatric Institute. His health deteriorated shortly after his arrival so that he was hospitalized. He died three years later.
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was a fellow German psychiatrist, twelve years
Alzheimer's junior, who reported twelve cases of senile dementia in 1907 around the time that Alzheimer published his short paper summarizing his presentation.
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On 8 April 1906, Frau Deter died, and
Alzheimer had her medical records and brain brought to Munich where he was working in Kraepelin's laboratory. With two Italian physicians, he used the newly developed
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In the early 1990s, critics began to question
Alzheimer's findings and form their own hypotheses based on Alzheimer's notes and papers. Amaducci and colleagues hypothesized that Auguste Deter had
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Alzheimer and
Fischer had different interpretations of the disease, but owing to Alzheimer's short life, they never had the opportunity to meet and discuss their ideas.
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Benjamin, Sheldon; MacGillivray, Lindsey; Schildkrout, Barbara; Cohen-Oram, Alexis; Lauterbach, Margo D.; Levin, Leonard L. (24 August 2018).
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when Alois was still young in order to give their children an opportunity to attend the Royal
Humanistic Gymnasium. After graduating with
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Alzheimer is known for having a variety of medical interests including vascular diseases of the brain, early dementia, brain tumors,
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Engstrom, Eric J. (2007). "Researching
Dementia in Imperial Germany: Alois Alzheimer and the Economies of Psychiatric Practice".
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438:, and even received a fine for disturbing the peace while out with his team. In 1887, Alzheimer graduated from Würzburg as
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November 1906 Alzheimer discussed his findings on the brain pathology and symptoms of presenile dementia publicly, at the
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In 1888, Alzheimer spent five months assisting mentally ill women before he took an office in the city mental asylum in
375:. He is credited with identifying the first published case of "presenile dementia", which Kraepelin later identified as
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In 1894, Alzheimer married
Cecilie Simonette Nathalie Geisenheimer, with whom he had three children. She died in 1901.
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Strobel, Gabrielle. "Prague: What say you, Alois – Should it be 'Alzheimer-Fischer' disease?".
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Graeber, M. B.; Mehraein, Parviz (1 December 1999). "Reanalysis of the first case of Alzheimer's disease".
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away without any questions or comments on his discovery of the pathology of a type of senile dementia.
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gave a report similar to that of Alzheimer at a lecture five months before Alzheimer.
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Cipriani, Gabriele; Dolciotti, Cristina; Picchi, Lucia; Bonuccelli, Ubaldo (2011).
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on Alois Alzheimer and Alzheimer's disease, selected from peer-reviewed journals
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Berrios, G. E. (1 November 1990). "Alzheimer's disease: A conceptual history".
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made among psychiatrists at asylums and universities to receive cadavers.
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was created from a revision of this article dated 23 March 2018
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641:, Poland). His body was buried four days later, next to Cecilie's at the
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Alois Alzheimer's Biography, International Brain Research Organization
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In 1901, Alzheimer observed a patient at the Frankfurt asylum named
1274:"Six Landmark Case Reports Essential for Neuropsychiatric Literacy"
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539:. These brain anomalies became identifiers of what is now known as
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In August 1912, Alzheimer fell ill on the train on his way to the
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434:. In his final year at university, he was a member of a fencing
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Alzheimer. La vida de un médico y la historia de una enfermedad
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629:. He died of heart failure on 19 December 1915 at age 51, in
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Academic staff of the Ludwig Maximilian University of Munich
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Alzheimer: The Life of a Physician and Career of a Disease
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European Archives of Psychiatry and Clinical Neuroscience
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The Journal of Neuropsychiatry and Clinical Neurosciences
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Institute for the Insane and Epileptic ("Irrenschloss"),
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Hippius, Hanns; Neundörfer, Gabriele (31 March 2003).
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Zeitschrift für die gesamte Neurologie und Psychiatrie
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Alzheimer in his later years just before his death (
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German psychiatrist and neuropathologist (1864–1915)
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476:While at the Frankfurt asylum, Alzheimer also met
407:in the family's hometown. The family was devoutly
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550:First description of Alzheimer's dementia (1906)
497:Silesian Friedrich Wilhelm University in Breslau
363:; 14 June 1864 – 19 December 1915) was a German
205:Silesian Friedrich Wilhelm University in Breslau
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1193:Yang, Hyun Duk; et al. (December 2016).
817:
777:International Journal of Geriatric Psychiatry
736:(18th ed.). Cambridge University Press.
992:"Alzheimer and his disease: a brief history"
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762:Random House Webster's Unabridged Dictionary
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108:Julius Maximilian University of Würzburg
1332:. New York: Columbia University Press.
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1160:American Journal of Alzheimer's Disease
903:, marktbreit.de; accessed 14 July 2017.
867:Maurer, Konrad; Maurer, Ulrike (2006).
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422:in 1883, Alzheimer studied medicine at
156: 1894; died 1901)
143:Cecilie Simonette Nathalie Geisenheimer
1578:Physicians from the Kingdom of Bavaria
1555:
1357:"Tuebingen: The Man Behind the Eponym"
1158:Lefroy, Richard B. (2000). "Sign In".
1157:
1047:"The discovery of Alzheimer's disease"
918:"The discovery of Alzheimer's disease"
820:"The tangled story of Alois Alzheimer"
493:Ludwig Maximilian University of Munich
200:Ludwig Maximilian University of Munich
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37:Official Portrait of Alois Alzheimer
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125:First published case of "presenile
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1051:Dialogues in Clinical Neuroscience
922:Dialogues in Clinical Neuroscience
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487:In 1904, Alzheimer completed his
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1291:10.1176/appi.neuropsych.18020027
1195:"History of Alzheimer's Disease"
1109:Culture, Medicine and Psychiatry
696:German inventors and discoverers
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730:(eds.). "Alzheimer's disease".
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1387:Journal of Alzheimer's Disease
1249:. 2 April 2014. Archived from
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1628:University of Würzburg alumni
1623:University of Tübingen alumni
1544:"Alois Alzheimer (1864–1915)"
1324:Maurer K.; Maurer U. (2003).
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90:(present-day Wrocław, Poland)
1363:. Alzforum. 16 November 2006
873:. Ediciones Díaz de Santos.
818:Zilka, N.; M. Novak (2006).
675:metachromatic leukodystrophy
360:[ˈaːlɔɪsˈʔaltshaɪmɐ]
113:Friedrich Wilhelm University
7:
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10:
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1211:10.12779/dnd.2016.15.4.115
1172:10.1177/153331750001500404
679:vascular dementing disease
1527:Alzheimer's: 100 years on
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1008:10.1007/s10072-010-0454-7
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899:21 December 2008 at the
894:"Alzheimer´s Birthplace"
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383:Early life and education
669:Critics and rediscovery
643:Frankfurt Main Cemetery
575:Personal life and death
537:neurofibrillary tangles
182:Psychiatrist, physician
1588:German Roman Catholics
1583:German neuroscientists
1573:People from Marktbreit
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1459:Listen to this article
619:valvular heart disease
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569:Handbook of Psychiatry
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432:University of Würzburg
428:University of Tübingen
395:Alzheimer was born in
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996:Neurological Sciences
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757:"Alzheimer's disease"
655:Solomon Carter Fuller
607:University of Breslau
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1598:German psychiatrists
1510:More spoken articles
424:University of Berlin
1593:Alzheimer's disease
541:Alzheimer's disease
505:forensic psychiatry
377:Alzheimer's disease
131:Alzheimer's disease
1542:Graeber Manuel B.
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440:Doctor of Medicine
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83:Kingdom of Prussia
61:Kingdom of Bavaria
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1339:978-0-231-11896-5
1243:"Alois Alzheimer"
880:978-84-7978-758-5
827:Bratisl Lek Listy
743:978-0-521-15255-6
371:and colleague of
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1563:1864 births
1257:19 February
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467:Franz Nissl
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1367:25 January
702:References
456:Emil Sioli
436:fraternity
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