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assertions of the uniqueness of the disease. Lithium was later found in 1949 to be an effective treatment for mood disorders, although the concept of a uric acid diathesis was fully discredited.
223:. He asserted that the disease was extremely common in his practice. Based on observations he made of his patients' urine, he hypothesized that the illness was related to an excess of
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In 1886 Lange published "On
Periodical Depressions and their Pathogenesis," an exposé on the previously undescribed illness of periodic depressions without mania known today as
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Book: In
Commemoration of the Centenary of the Death of Carl Lange. The Lange Theory of 'Periodical Depressions' - A Landmark in the History of Lithium Therapy
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Salvadore, G; Viale, CI; Luckenbaugh, DA; Zanatto, VC; Portela, LV; Souza, DO; Zarate, CA Jr; Machado-Vieira, R (2010).
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are developed from, and can be reduced to, physiological reactions to stimuli. Seemingly independently, the
American
200:, he achieved world fame with his 1885 work "On Emotions: A Psycho-Physiological Study". In it, he posited that all
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had published a similar work the year before, but unlike James, Lange specifically stated that vasomotor changes
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and graduated in 1859 with a reputation for brilliance. After publishing on the neurological pathologies of
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312:"Increased uric acid levels in drug-naĂŻve subjects with bipolar disorder during a first manic episode"
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Schioldann, J. (2011). "'On periodical depressions and their pathogenesis' by Carl Lange (1886)".
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in the blood and advocated for methods of reducing this substance, including the use of
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But a connection of uric acid and depression is not without possibility.
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History of the
Introduction of Lithium into Medicine and Psychiatry
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Amdisen, A (1985). "Carl Lange pĂĄ fransk visit i psykiatrien ".
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Progress in Neuro-Psychopharmacology and
Biological Psychiatry
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Lund, M (1991). "C. Lange – Danmarks første neurolog ".
416:. Adelaide: Adelaide Academic Press. p. 390.
407:. Adelaide: Adelaide Academic Press. p. 200.
376:Lange, Carl (1868). "On acute bulbar paralysis".
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241:He died in Copenhagen in 1900 at the age of 65.
180:, Denmark, Lange attended medical school at the
454:19th-century Copenhagen City Council members
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387:Rehabilitation and Care of the Handicapped
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212:emotions. The theory became known as the
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421:Snorrason, E (1973). "Carl Lange".
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423:Dictionary of Scientific Biography
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365:Dansk Medicinhistorisk Aarbog
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214:James–Lange theory of emotion
109:James–Lange theory of emotion
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176:Born to a wealthy family in
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389:. Copenhagen: E. Jespersen.
328:10.1016/j.pnpbp.2010.02.027
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412:Schioldann, Johan (2009).
403:Schioldann, Johan (2001).
385:Lange, Carl (1871–1876).
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281:10.1177/0957154x10396807
182:University of Copenhagen
140:University of Copenhagen
99:University of Copenhagen
269:History of Psychiatry
449:Danish psychologists
275:(85 Pt 1): 108–130.
444:Danish neurologists
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136:Institutions
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68:(1900-04-29)
464:1900 deaths
459:1834 births
233:nosological
198:spinal cord
178:Vordingborg
85:Nationality
52:Vordingborg
438:Categories
245:References
171:psychology
167:psychiatry
130:Psychiatry
74:Copenhagen
44:1834-12-04
225:uric acid
163:neurology
159:physician
126:Neurology
346:20206224
297:37373802
289:21879580
202:emotions
371:: 9–40.
337:3008668
229:lithium
186:aphasia
78:Denmark
56:Denmark
429:: 7–8.
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169:, and
156:Danish
122:Fields
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293:S2CID
342:PMID
285:PMID
63:Died
38:Born
332:PMC
324:doi
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210:are
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