816:
approximately equal to 40 mg of zuranolone or placebo, also for 14 days. Participants in both studies were monitored for at least four weeks after the 14-day treatment. The primary endpoint of both studies was the change in depressive symptoms using the total score from the 17-item
Hamilton depression rating scale (HAMD-17), measured at day 15. Participants in the zuranolone groups showed significantly more improvement in their symptoms compared to those in the placebo groups. The treatment effect was maintained at day 42—four weeks after the last dose of zuranolone.
541:
42:
5394:
1184:
610:
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criteria for a major depressive episode and whose symptoms began in the third trimester or within four weeks of delivery. In study 1, participants received 50 mg of zuranolone or placebo once daily in the evening for 14 days. In study 2, participants received another zuranolone product that was
1272:
Martinez
Botella G, Salituro FG, Harrison BL, Beresis RT, Bai Z, Blanco MJ, et al. (2017). "Neuroactive Steroids. 2. 3α-Hydroxy-3β-methyl-21-(4-cyano-1H-pyrazol-1'-yl)-19-nor-5β-pregnan-20-one (SAGE-217): A Clinical Next Generation Neuroactive Steroid Positive Allosteric Modulator of the
1432:
808:
The efficacy of zuranolone for the treatment of postpartum depression in adults was demonstrated in two randomized, double-blind, placebo-controlled, multicenter studies. The trial participants were women with postpartum depression who met the
5120:
776:
noting that zuranolone can impact a person's ability to drive and perform other potentially hazardous activities. The use of zuranolone may cause suicidal thoughts and behavior. Zuranolone may also cause fetal harm.
1469:
Clayton AH, Lasser R, Parikh SV, Iosifescu DV, Jung J, Kotecha M, et al. (May 2023). "Zuranolone for the
Treatment of Adults With Major Depressive Disorder: A Randomized, Placebo-Controlled Phase 3 Trial".
5020:
3970:
882:, subjects in the zuranolone group (50 mg oral zuranolone once daily for 14 days) experienced statistically significant and sustained improvements in depressive symptoms (as measured by
652:
InChI=1S/C25H35N3O2/c1-24(30)9-7-18-17(11-24)3-4-20-19(18)8-10-25(2)21(20)5-6-22(25)23(29)15-28-14-16(12-26)13-27-28/h13-14,17-22,30H,3-11,15H2,1-2H3/t17-,18+,19-,20-,21+,22-,24-,25+/m1/s1
4052:
1433:"FDA Approves Zurzuvae (zuranolone), the First and Only Oral Treatment Approved for Women with Postpartum Depression, and Issues a Complete Response Letter for Major Depressive Disorder"
922:
4082:
2771:
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Zuranolone was approved for medical use in the United States for the treatment of postpartum depression in August 2023. It was developed by Sage
Therapeutics and
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Blanco MJ, La D, Coughlin Q, Newman CA, Griffin AM, Harrison BL, et al. (2018). "Breakthroughs in neuroactive steroid drug discovery".
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for "A Study to
Evaluate the Efficacy and Safety of SAGE-217 in Participants With Severe Postpartum Depression (PPD)" at
1810:
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4799:
825:
717:
644:
98:
974:"GABAkines - Advances in the discovery, development, and commercialization of positive allosteric modulators of GABA
2732:
1314:
307:
233:
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840:(FDA) for the treatment of postpartum depression in August 2023. The FDA granted the application for zuranolone
4319:
1653:
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1403:(2019). "International nonproprietary names for pharmaceutical substances (INN): recommended INN: list 82".
1038:"Intravenous brexanolone for postpartum depression: what it is, how well does it work, and will it be used?"
769:
The most common side effects include drowsiness, dizziness, diarrhea, fatigue, and urinary tract infection.
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17:
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Deligiannidis KM, Meltzer-Brody S, Gunduz-Bruce H, Doherty J, Jonas J, Li S, et al. (2021).
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178:
112:
1564:"Zuranolone as an oral adjunct to treatment of Parkinsonian tremor: A phase 2, open-label study"
5449:
2966:
2555:
2026:
1093:"Zurzuvae (zuranolone) capsules, for oral use, [controlled substance schedule pending]"
902:
498:
266:
438:
5311:
4989:
1996:
758:
675:
373:
1349:"Preclinical characterization of zuranolone (SAGE-217), a selective neuroactive steroid GABA
5093:
3719:
3594:
2675:
2590:
794:
458:
286:
4183:
785:
Zuranolone was developed as an improvement on the intravenously administered neurosteroid
540:
8:
5219:
5102:
4229:
4155:
3244:
3086:
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2501:
2441:
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679:
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for "A Study to
Evaluate SAGE-217 in Participants With Severe Postpartum Depression" at
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4757:
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3419:
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1692:
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1539:
1515:"Effect of Zuranolone vs Placebo in Postpartum Depression: A Randomized Clinical Trial"
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Althaus AL, Ackley MA, Belfort GM, Gee SM, Dai J, Nguyen DP, et al. (2020).
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923:"Schedules of Controlled Substances: Placement of Zuranolone in Schedule IV"
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designations. Approval of
Zurzuvae was granted to Sage Therapeutics, Inc.
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2011:
1981:
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suitable for once-daily administration. Its half-life is around 16 to 23
418:
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1991:
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1717:
1456:"Sage Hints at Difficult Decisions After Zuranolone's Rejection in MDD"
1315:"FDA approves postpartum depression pill from two Cambridge drug firms"
1271:
972:
Cerne R, Lippa A, Poe MM, Smith JL, Jin X, Ping X, et al. (2022).
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1932:
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754:
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1910:
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886:
score) throughout the treatment and follow-up periods of the study.
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2016:
2001:
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1187:
This article incorporates text from this source, which is in the
859:(CRL) by the FDA due to insufficient evidence of effectiveness.
851:
Zuranolone has also been under development for the treatment of
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4814:
4767:
4638:
4620:
4580:
4264:
4062:
1882:
1705:
1562:
Bullock A, Kaul I, Li S, Silber C, Doherty J, Kanes SJ (2021).
742:
509:
4590:
2073:
1162:"FDA Approves First Oral Treatment for Postpartum Depression"
600:
489:
41:
1468:
4023:
1943:
469:
86:
80:
1811:
65:
1399:
915:
74:
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to assess its efficacy and safety for the treatment of
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1236:
632:
O=C(CN1N=CC(C#N)=C1)2CC3()4()CC5()C(C)(O)CC5()4()CC32C
5382:
812:
99:
89:
77:
62:
1915:
Tooltip
Serotonin antagonist and reuptake inhibitors
1768:
Tooltip Serotonin–norepinephrine reuptake inhibitors
1087:
1085:
1083:
1081:
83:
71:
2249:
1849:
Tooltip Norepinephrine–dopamine reuptake inhibitors
1561:
68:
1313:
1156:
1154:
1152:
1150:
1148:
1146:
1144:
1142:
1140:
971:
5332:Unsorted benzodiazepine site positive modulators:
2091:
1506:
1138:
1136:
1134:
1132:
1130:
1128:
1126:
1124:
1122:
1120:
1078:
5406:
2314:
397:
2651:
1710:Tooltip Selective serotonin reuptake inhibitors
855:, but the application for this use was given a
372:
1117:
5440:GABAA receptor positive allosteric modulators
2765:
1654:
1199:
1197:
1447:
1239:Bioorganic & Medicinal Chemistry Letters
1232:
1230:
1035:
674:, is a medication used for the treatment of
148:
2781:
2685:
2502:
2442:
1948:Tooltip Serotonin modulator and stimulators
1555:
1462:
1340:
1031:
1029:
967:
965:
889:Other investigational applications include
351:-cyclopentaphenanthren-17-yl)-2-oxoethyl)-1
2772:
2758:
1816:Tooltip Norepinephrine reuptake inhibitors
1668:
1661:
1647:
1435:(Press release). Biogen Inc. 4 August 2023
1265:
1194:
1042:Therapeutic Advances in Psychopharmacology
539:
437:
1579:
1538:
1416:
1376:
1227:
1061:
1001:
457:
27:Medication used for postpartum depression
2543:
1311:
1026:
962:
347:)-3-Hydroxy-3,13-dimethylhexadecahydro-1
1353:receptor positive allosteric modulator"
417:
14:
5407:
946:
944:
862:In the United States, zuranolone is a
819:
530:
206:receptor positive allosteric modulator
2753:
2638:
2542:
2313:
2072:
1685:
1642:
517:
497:
242:
139:
125:SAGE-217; S-812217; SGE-797; BIIB-125
5373:GABA metabolism/transport modulators
1568:Journal of the Neurological Sciences
1453:
874:In a randomized, placebo-controlled
4990:Trichloroethane (methyl chloroform)
2254:Tooltip Tetracyclic antidepressants
941:
477:
388:
24:
4053:11-Methoxy-12-hydroxydehydrokavain
1472:The American Journal of Psychiatry
1328:from the original on 6 August 2023
1215:from the original on 29 March 2019
1105:from the original on 5 August 2023
836:Zuranolone was approved by the US
801:hours, compared to approximately 9
764:
25:
5471:
4800:Acetylglycinamide chloral hydrate
2639:
2096:Tooltip Tricyclic antidepressants
1608:
826:international nonproprietary name
5392:
1531:10.1001/jamapsychiatry.2021.1559
1369:10.1016/j.neuropharm.2020.108333
1182:
994:10.1016/j.pharmthera.2021.108035
864:Schedule IV controlled substance
570:
564:
58:
40:
5220:Menthyl isovalerate (validolum)
1425:
1393:
1305:
982:Pharmacology & Therapeutics
831:
748:
657:Key:HARRKNSQXBRBGZ-GVKWWOCJSA-N
5415:Drugs not assigned an ATC code
4169:Allopregnanolone (brexanolone)
1279:Journal of Medicinal Chemistry
1172:(Press release). 4 August 2023
576:
558:
13:
1:
5365:Receptor/signaling modulators
3921:Ampelopsin (dihydromyricetin)
908:
728:positive allosteric modulator
5115:ergoloid (dihydroergotoxine)
4200:anabolic-androgenic steroids
2982:Butabarbital/Secbutabarbital
2787:receptor positive modulators
2316:Monoamine oxidase inhibitors
1312:Saltzman J (4 August 2023).
1291:10.1021/acs.jmedchem.7b00846
1168:Food and Drug Administration
838:Food and Drug Administration
772:The US FDA label contains a
670:, sold under the brand name
7:
3755:Triflunordazepam (Ro5-2904)
2510:Tooltip Monoamine oxidase B
2450:Tooltip Monoamine oxidase A
2079:tetracyclic antidepressants
1036:Faden J, Citrome L (2020).
869:
10:
5476:
4083:5,6,7,8-Tetrahydroyangonin
1987:Dextromethorphan/bupropion
1443:– via GlobeNewswire.
1251:10.1016/j.bmcl.2017.11.043
780:
548:Chemical and physical data
5358:
5008:
4776:
4713:
4680:
4647:
4619:
4333:
4275:Pregnanolone (eltanolone)
4154:
4111:
4022:
3994:
3906:
3788:
3230:
2917:
2818:Chlorobutanol (cloretone)
2793:
2710:
2645:
2634:
2551:
2538:
2500:
2440:
2326:
2322:
2309:
2285:
2247:
2089:
2085:
2068:
1969:
1941:
1908:
1875:
1842:
1809:
1761:
1703:
1699:
1681:
1581:10.1016/j.jns.2020.117277
1484:10.1176/appi.ajp.20220459
1401:World Health Organization
880:major depressive disorder
853:major depressive disorder
640:
620:
598:
585:
552:
547:
528:
508:
488:
468:
448:
428:
408:
383:
363:
303:
298:
285:
275:
265:
257:
232:
227:
211:
191:
177:
159:
129:
121:
111:
53:
48:
39:
5369:GABA receptor modulators
5279:sulfonmethane (sulfonal)
2693:Rubidium chloride (RbCl)
1054:10.1177/2045125320968658
857:Complete Response Letter
355:-pyrazole-4-carbonitrile
2556:Atypical antipsychotics
805:hours for brexanolone.
726:, zuranolone acts as a
711:urinary tract infection
5255:Retigabine (ezogabine)
4531:Lirequinil (Ro41-3696)
4098:7,8-Dihydromethysticin
4088:5,6-Dehydromethysticin
2967:Benzylbutylbarbiturate
1626:Clinical trial number
1614:Clinical trial number
1273:(γ-Aminobutyric Acid)
759:postpartum depression
757:for the treatment of
676:postpartum depression
5310:constituents (e.g.,
5094:Deuterated etifoxine
4156:Neuroactive steroids
4126:Apronal (apronalide)
3978:constituents (e.g.,
3595:N-Desalkylflurazepam
2677:Hypericum perforatum
2545:Adjunctive therapies
1405:WHO Drug Information
1048:: 2045125320968658.
795:biological half-life
5103:dihydroergocryptine
4415:Pyrazolopyrimidines
4073:5,6-Dihydroyangonin
4058:7,8-Dihydroyangonin
3245:3-Hydroxyphenazepam
3087:Methylphenobarbital
1693:receptor modulators
1689:reuptake inhibitors
903:Parkinson's disease
820:Society and culture
36:
5197:4-O-methylhonokiol
4860:Dichloralphenazone
4758:Methylmethaqualone
4335:Nonbenzodiazepines
4048:Desmethoxyyangonin
4043:11-Hydroxyyangonin
4038:11-Methoxyyangonin
4033:10-Methoxyyangonin
3420:Ethyl carfluzepate
3022:Cyclopentobarbital
2737:Never to phase III
1634:ClinicalTrials.gov
1622:ClinicalTrials.gov
895:bipolar depression
824:Zuranolone is the
32:
5380:
5379:
5340:MRK-409 (MK-0343)
5111:dihydroergotamine
5054:potassium bromide
5048:compounds (e.g.,
4995:Trichloroethylene
4763:Nitromethaqualone
4682:Pyrazolopyridines
4184:3α-Androstanediol
4078:7,8-Dihydrokavain
3430:Ethyl loflazepate
3207:Thiotetrabarbital
2823:Ethanol (alcohol)
2747:
2746:
2706:
2705:
2679:(St. John's Wort)
2630:
2629:
2595:lithium carbonate
2534:
2533:
2530:
2529:
2305:
2304:
2301:
2300:
2114:Amitriptylinoxide
2064:
2063:
2060:
2059:
1357:Neuropharmacology
1285:(18): 7810–7819.
929:. 31 October 2023
789:, with high oral
665:
664:
611:Interactive image
246:
142:
16:(Redirected from
5467:
5397:
5396:
5395:
5388:
5099:Dihydroergolines
5016:3-Hydroxybutanal
4649:Piperidinediones
4382:Imidazopyridines
3916:6-Methylapigenin
3848:Hydroxyphenamate
3720:SH-053-R-CH3-2′F
3425:Ethyl dirazepate
3305:Chlordiazepoxide
3197:Thiobutabarbital
2909:Trifluoroethanol
2899:Trichloroethanol
2889:-Pentanol (2M2B)
2783:
2774:
2767:
2760:
2751:
2750:
2687:
2653:
2636:
2635:
2609:triiodothyronine
2605:Thyroid hormones
2540:
2539:
2511:
2507:
2451:
2447:
2392:Phenoxypropazine
2324:
2323:
2311:
2310:
2255:
2251:
2097:
2093:
2087:
2086:
2070:
2069:
1949:
1945:
1916:
1912:
1883:
1879:
1850:
1846:
1817:
1813:
1769:
1765:
1711:
1707:
1701:
1700:
1683:
1682:
1663:
1656:
1649:
1640:
1639:
1602:
1601:
1583:
1559:
1553:
1552:
1542:
1510:
1504:
1503:
1466:
1460:
1459:
1451:
1445:
1444:
1442:
1440:
1429:
1423:
1422:
1420:
1397:
1391:
1390:
1380:
1344:
1338:
1337:
1335:
1333:
1321:The Boston Globe
1317:
1309:
1303:
1302:
1269:
1263:
1262:
1234:
1225:
1224:
1222:
1220:
1201:
1192:
1186:
1185:
1181:
1179:
1177:
1158:
1115:
1114:
1112:
1110:
1104:
1097:
1089:
1076:
1075:
1065:
1033:
1024:
1023:
1005:
969:
960:
959:
948:
939:
938:
936:
934:
927:Federal Register
919:
899:essential tremor
804:
800:
685:The most common
613:
593:
578:
572:
566:
560:
543:
532:
521:
501:
481:
461:
441:
421:
401:
391:
390:
376:
290:
244:
241:
152:
141:
138:
103:
96:
95:
92:
91:
88:
85:
82:
79:
76:
73:
70:
67:
64:
44:
37:
35:
31:
21:
5475:
5474:
5470:
5469:
5468:
5466:
5465:
5464:
5435:Antidepressants
5430:Anticonvulsants
5405:
5404:
5403:
5393:
5391:
5383:
5381:
5376:
5354:
5312:isovaleric acid
5275:Sulfonylalkanes
5173:Hopantenic acid
5157:tolfenamic acid
5145:flufenamic acid
5107:dihydroergosine
5050:lithium bromide
5009:Others/unsorted
5004:
4865:Dichloromethane
4840:Chloral hydrate
4835:Chloral betaine
4772:
4709:
4676:
4643:
4615:
4344:Cyclopyrrolones
4329:
4235:Etiocholanolone
4150:
4107:
4068:5-Hydroxykavain
4018:
3990:
3902:
3784:
3232:Benzodiazepines
3226:
3037:Ethallobarbital
3032:Enallylpropymal
2913:
2894:Tribromoethanol
2881:-Butanol (2M2P)
2827:alcoholic drink
2789:
2786:
2778:
2748:
2743:
2742:
2727:Clinical trials
2702:
2641:
2626:
2622:
2614:
2599:lithium citrate
2547:
2526:
2509:
2506:
2496:
2449:
2446:
2436:
2412:Tranylcypromine
2318:
2297:
2281:
2253:
2243:
2095:
2081:
2056:
1965:
1947:
1937:
1914:
1904:
1881:
1871:
1848:
1838:
1815:
1805:
1786:Levomilnacipran
1767:
1757:
1709:
1695:
1677:
1670:Antidepressants
1667:
1611:
1606:
1605:
1560:
1556:
1519:JAMA Psychiatry
1511:
1507:
1467:
1463:
1452:
1448:
1438:
1436:
1431:
1430:
1426:
1398:
1394:
1352:
1345:
1341:
1331:
1329:
1310:
1306:
1276:
1270:
1266:
1235:
1228:
1218:
1216:
1203:
1202:
1195:
1183:
1175:
1173:
1160:
1159:
1118:
1108:
1106:
1102:
1095:
1091:
1090:
1079:
1034:
1027:
977:
970:
963:
956:DrugBank Online
950:
949:
942:
932:
930:
921:
920:
916:
911:
876:phase III trial
872:
842:priority review
834:
822:
802:
798:
791:bioavailability
783:
767:
765:Adverse effects
751:
735:
707:nasopharyngitis
661:
658:
653:
648:
647:
636:
633:
628:
627:
616:
591:
581:
575:
569:
563:
524:
504:
484:
464:
444:
424:
404:
387:
379:
359:
356:
311:
310:
288:
267:Protein binding
259:Pharmacokinetic
253:
223:
205:
180:
173:
170:Contraindicated
162:
155:
101:
97:
61:
57:
28:
23:
22:
15:
12:
11:
5:
5473:
5463:
5462:
5457:
5452:
5447:
5442:
5437:
5432:
5427:
5422:
5417:
5402:
5401:
5378:
5377:
5359:
5356:
5355:
5353:
5352:
5347:
5342:
5337:
5328:
5327:
5320:valerenic acid
5305:
5300:
5290:
5272:
5267:
5262:
5257:
5252:
5247:
5242:
5237:
5232:
5227:
5222:
5217:
5212:
5190:
5185:
5180:
5175:
5170:
5165:
5160:
5149:mefenamic acid
5138:
5133:
5128:
5123:
5118:
5096:
5091:
5086:
5081:
5076:
5071:
5066:
5061:
5058:sodium bromide
5043:
5033:
5028:
5023:
5018:
5012:
5010:
5006:
5005:
5003:
5002:
4997:
4992:
4987:
4982:
4977:
4972:
4967:
4962:
4957:
4952:
4947:
4942:
4937:
4932:
4927:
4925:Methoxypropane
4922:
4920:Methoxyflurane
4917:
4912:
4907:
4902:
4897:
4892:
4887:
4882:
4880:Ethyl chloride
4877:
4872:
4867:
4862:
4857:
4852:
4847:
4842:
4837:
4832:
4827:
4822:
4817:
4812:
4807:
4802:
4797:
4792:
4786:
4784:
4774:
4773:
4771:
4770:
4765:
4760:
4755:
4750:
4745:
4740:
4735:
4730:
4725:
4719:
4717:
4715:Quinazolinones
4711:
4710:
4708:
4707:
4702:
4697:
4692:
4686:
4684:
4678:
4677:
4675:
4674:
4669:
4664:
4659:
4653:
4651:
4645:
4644:
4642:
4641:
4636:
4631:
4625:
4623:
4617:
4616:
4614:
4613:
4608:
4603:
4598:
4593:
4588:
4583:
4578:
4573:
4568:
4563:
4558:
4553:
4548:
4543:
4538:
4533:
4528:
4523:
4518:
4513:
4508:
4503:
4498:
4493:
4488:
4483:
4478:
4473:
4468:
4458:
4457:
4452:
4447:
4442:
4437:
4432:
4427:
4422:
4410:
4409:
4404:
4399:
4394:
4389:
4377:
4376:
4371:
4366:
4361:
4356:
4351:
4339:
4337:
4331:
4330:
4328:
4327:
4322:
4317:
4312:
4307:
4302:
4297:
4292:
4287:
4282:
4277:
4272:
4267:
4262:
4257:
4252:
4247:
4242:
4237:
4232:
4227:
4222:
4217:
4212:
4207:
4202:
4196:
4191:
4186:
4181:
4176:
4171:
4166:
4160:
4158:
4152:
4151:
4149:
4148:
4143:
4138:
4133:
4128:
4123:
4117:
4115:
4109:
4108:
4106:
4105:
4100:
4095:
4090:
4085:
4080:
4075:
4070:
4065:
4060:
4055:
4050:
4045:
4040:
4035:
4029:
4027:
4020:
4019:
4017:
4016:
4011:
4006:
4000:
3998:
3992:
3991:
3989:
3988:
3983:
3973:
3968:
3963:
3958:
3953:
3948:
3943:
3938:
3933:
3928:
3923:
3918:
3912:
3910:
3904:
3903:
3901:
3900:
3895:
3890:
3885:
3880:
3875:
3870:
3865:
3860:
3855:
3850:
3845:
3840:
3835:
3830:
3825:
3820:
3815:
3810:
3805:
3800:
3794:
3792:
3786:
3785:
3783:
3782:
3777:
3772:
3767:
3762:
3757:
3752:
3747:
3742:
3737:
3732:
3727:
3722:
3717:
3712:
3707:
3702:
3697:
3692:
3687:
3682:
3677:
3672:
3667:
3662:
3657:
3652:
3647:
3642:
3637:
3632:
3627:
3622:
3617:
3612:
3607:
3602:
3597:
3592:
3587:
3582:
3577:
3572:
3567:
3562:
3557:
3552:
3547:
3542:
3537:
3532:
3527:
3522:
3517:
3512:
3507:
3502:
3497:
3492:
3487:
3482:
3477:
3472:
3467:
3462:
3457:
3452:
3447:
3442:
3437:
3432:
3427:
3422:
3417:
3412:
3407:
3402:
3397:
3392:
3387:
3382:
3377:
3372:
3367:
3362:
3357:
3352:
3347:
3342:
3337:
3332:
3327:
3322:
3317:
3312:
3307:
3302:
3297:
3292:
3287:
3282:
3277:
3272:
3267:
3262:
3257:
3252:
3247:
3242:
3236:
3234:
3228:
3227:
3225:
3224:
3219:
3214:
3209:
3204:
3199:
3194:
3189:
3184:
3179:
3174:
3169:
3164:
3159:
3154:
3149:
3144:
3139:
3137:Propylbarbital
3134:
3129:
3124:
3119:
3114:
3109:
3104:
3099:
3094:
3089:
3084:
3079:
3074:
3069:
3064:
3059:
3054:
3049:
3044:
3039:
3034:
3029:
3024:
3019:
3014:
3012:Crotylbarbital
3009:
3004:
2999:
2994:
2989:
2984:
2979:
2977:Brophebarbital
2974:
2972:Brallobarbital
2969:
2964:
2959:
2954:
2949:
2944:
2939:
2934:
2929:
2923:
2921:
2915:
2914:
2912:
2911:
2906:
2901:
2896:
2891:
2883:
2875:
2870:
2865:
2860:
2858:Methylpentynol
2855:
2850:
2845:
2840:
2835:
2830:
2820:
2815:
2810:
2805:
2799:
2797:
2791:
2790:
2784:
2777:
2776:
2769:
2762:
2754:
2745:
2744:
2741:
2740:
2739:
2738:
2735:
2724:
2718:
2712:
2711:
2708:
2707:
2704:
2703:
2701:
2700:
2695:
2690:
2681:
2673:
2656:
2650:Ademetionine (
2646:
2643:
2642:
2632:
2631:
2628:
2627:
2625:
2624:
2620:
2612:
2602:
2588:
2583:
2552:
2549:
2548:
2536:
2535:
2532:
2531:
2528:
2527:
2525:
2524:
2515:
2513:
2504:
2498:
2497:
2495:
2494:
2489:
2484:
2479:
2474:
2469:
2464:
2455:
2453:
2444:
2438:
2437:
2435:
2434:
2425:
2424:
2415:
2414:
2409:
2404:
2399:
2394:
2389:
2384:
2379:
2374:
2369:
2364:
2359:
2354:
2349:
2344:
2339:
2330:
2328:
2320:
2319:
2307:
2306:
2303:
2302:
2299:
2298:
2296:
2295:
2289:
2287:
2283:
2282:
2280:
2279:
2274:
2269:
2264:
2258:
2256:
2245:
2244:
2242:
2241:
2236:
2231:
2226:
2221:
2216:
2211:
2206:
2201:
2196:
2191:
2186:
2181:
2176:
2171:
2169:Imipraminoxide
2166:
2161:
2156:
2151:
2146:
2141:
2136:
2131:
2126:
2121:
2116:
2111:
2106:
2100:
2098:
2083:
2082:
2066:
2065:
2062:
2061:
2058:
2057:
2055:
2054:
2049:
2044:
2039:
2034:
2029:
2024:
2019:
2014:
2009:
2004:
1999:
1994:
1989:
1984:
1979:
1973:
1971:
1967:
1966:
1964:
1963:
1958:
1952:
1950:
1939:
1938:
1936:
1935:
1930:
1925:
1919:
1917:
1906:
1905:
1903:
1902:
1897:
1892:
1886:
1884:
1873:
1872:
1870:
1869:
1864:
1859:
1853:
1851:
1840:
1839:
1837:
1836:
1831:
1826:
1820:
1818:
1807:
1806:
1804:
1803:
1798:
1793:
1788:
1783:
1778:
1776:Desvenlafaxine
1772:
1770:
1759:
1758:
1756:
1755:
1750:
1745:
1740:
1735:
1730:
1725:
1720:
1714:
1712:
1697:
1696:
1679:
1678:
1666:
1665:
1658:
1651:
1643:
1637:
1636:
1624:
1610:
1609:External links
1607:
1604:
1603:
1554:
1525:(9): 951–959.
1505:
1478:(9): 676–684.
1461:
1446:
1424:
1392:
1350:
1339:
1304:
1274:
1264:
1226:
1193:
1116:
1077:
1025:
975:
961:
940:
913:
912:
910:
907:
871:
868:
833:
830:
821:
818:
782:
779:
766:
763:
753:Zuranolone is
750:
747:
733:
678:. It is taken
663:
662:
660:
659:
656:
654:
651:
643:
642:
641:
638:
637:
635:
634:
631:
623:
622:
621:
618:
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604:
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589:
583:
582:
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522:
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512:
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505:
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502:
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486:
485:
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452:
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442:
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135:
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55:
51:
50:
46:
45:
26:
9:
6:
4:
3:
2:
5472:
5461:
5458:
5456:
5453:
5451:
5450:Neurosteroids
5448:
5446:
5443:
5441:
5438:
5436:
5433:
5431:
5428:
5426:
5423:
5421:
5418:
5416:
5413:
5412:
5410:
5400:
5390:
5389:
5386:
5375:
5374:
5370:
5366:
5363:
5357:
5351:
5348:
5346:
5343:
5341:
5338:
5336:
5333:
5330:
5329:
5325:
5321:
5317:
5316:isovaleramide
5313:
5309:
5306:
5304:
5301:
5298:
5294:
5291:
5288:
5284:
5280:
5276:
5273:
5271:
5268:
5266:
5263:
5261:
5258:
5256:
5253:
5251:
5248:
5246:
5243:
5241:
5238:
5236:
5233:
5231:
5228:
5226:
5223:
5221:
5218:
5216:
5213:
5210:
5206:
5202:
5198:
5194:
5191:
5189:
5186:
5184:
5181:
5179:
5176:
5174:
5171:
5169:
5166:
5164:
5161:
5158:
5154:
5153:niflumic acid
5150:
5146:
5142:
5139:
5137:
5134:
5132:
5129:
5127:
5124:
5122:
5119:
5116:
5112:
5108:
5104:
5100:
5097:
5095:
5092:
5090:
5087:
5085:
5082:
5080:
5079:Clomethiazole
5077:
5075:
5074:Chlormezanone
5072:
5070:
5067:
5065:
5064:Carbamazepine
5062:
5059:
5055:
5051:
5047:
5044:
5041:
5037:
5034:
5032:
5029:
5027:
5024:
5022:
5019:
5017:
5014:
5013:
5011:
5007:
5001:
4998:
4996:
4993:
4991:
4988:
4986:
4983:
4981:
4978:
4976:
4973:
4971:
4968:
4966:
4963:
4961:
4958:
4956:
4953:
4951:
4948:
4946:
4943:
4941:
4940:Nitrous oxide
4938:
4936:
4933:
4931:
4928:
4926:
4923:
4921:
4918:
4916:
4913:
4911:
4908:
4906:
4903:
4901:
4898:
4896:
4893:
4891:
4888:
4886:
4883:
4881:
4878:
4876:
4873:
4871:
4870:Diethyl ether
4868:
4866:
4863:
4861:
4858:
4856:
4853:
4851:
4848:
4846:
4843:
4841:
4838:
4836:
4833:
4831:
4828:
4826:
4823:
4821:
4818:
4816:
4813:
4811:
4808:
4806:
4803:
4801:
4798:
4796:
4793:
4791:
4788:
4787:
4785:
4783:
4779:
4775:
4769:
4766:
4764:
4761:
4759:
4756:
4754:
4751:
4749:
4746:
4744:
4741:
4739:
4736:
4734:
4731:
4729:
4726:
4724:
4721:
4720:
4718:
4716:
4712:
4706:
4703:
4701:
4698:
4696:
4693:
4691:
4688:
4687:
4685:
4683:
4679:
4673:
4672:Pyrithyldione
4670:
4668:
4665:
4663:
4660:
4658:
4655:
4654:
4652:
4650:
4646:
4640:
4637:
4635:
4632:
4630:
4627:
4626:
4624:
4622:
4618:
4612:
4609:
4607:
4604:
4602:
4599:
4597:
4594:
4592:
4589:
4587:
4584:
4582:
4579:
4577:
4574:
4572:
4569:
4567:
4564:
4562:
4559:
4557:
4554:
4552:
4549:
4547:
4544:
4542:
4539:
4537:
4534:
4532:
4529:
4527:
4524:
4522:
4519:
4517:
4514:
4512:
4509:
4507:
4504:
4502:
4499:
4497:
4494:
4492:
4489:
4487:
4484:
4482:
4479:
4477:
4474:
4472:
4469:
4467:
4463:
4460:
4459:
4456:
4453:
4451:
4448:
4446:
4443:
4441:
4438:
4436:
4433:
4431:
4428:
4426:
4423:
4421:
4417:
4416:
4412:
4411:
4408:
4405:
4403:
4400:
4398:
4395:
4393:
4390:
4388:
4384:
4383:
4379:
4378:
4375:
4372:
4370:
4367:
4365:
4362:
4360:
4357:
4355:
4352:
4350:
4346:
4345:
4341:
4340:
4338:
4336:
4332:
4326:
4323:
4321:
4318:
4316:
4313:
4311:
4308:
4306:
4303:
4301:
4298:
4296:
4293:
4291:
4288:
4286:
4283:
4281:
4278:
4276:
4273:
4271:
4268:
4266:
4263:
4261:
4258:
4256:
4253:
4251:
4248:
4246:
4243:
4241:
4238:
4236:
4233:
4231:
4228:
4226:
4223:
4221:
4218:
4216:
4213:
4211:
4208:
4206:
4203:
4201:
4197:
4195:
4192:
4190:
4187:
4185:
4182:
4180:
4177:
4175:
4172:
4170:
4167:
4165:
4162:
4161:
4159:
4157:
4153:
4147:
4144:
4142:
4139:
4137:
4134:
4132:
4129:
4127:
4124:
4122:
4119:
4118:
4116:
4114:
4110:
4104:
4101:
4099:
4096:
4094:
4091:
4089:
4086:
4084:
4081:
4079:
4076:
4074:
4071:
4069:
4066:
4064:
4061:
4059:
4056:
4054:
4051:
4049:
4046:
4044:
4041:
4039:
4036:
4034:
4031:
4030:
4028:
4025:
4021:
4015:
4012:
4010:
4007:
4005:
4002:
4001:
3999:
3997:
3993:
3987:
3984:
3981:
3977:
3974:
3972:
3969:
3967:
3964:
3962:
3959:
3957:
3954:
3952:
3949:
3947:
3944:
3942:
3939:
3937:
3934:
3932:
3929:
3927:
3924:
3922:
3919:
3917:
3914:
3913:
3911:
3909:
3905:
3899:
3896:
3894:
3891:
3889:
3886:
3884:
3881:
3879:
3878:Phenprobamate
3876:
3874:
3871:
3869:
3866:
3864:
3861:
3859:
3856:
3854:
3851:
3849:
3846:
3844:
3843:Hexapropymate
3841:
3839:
3836:
3834:
3831:
3829:
3826:
3824:
3821:
3819:
3818:Difebarbamate
3816:
3814:
3811:
3809:
3806:
3804:
3801:
3799:
3796:
3795:
3793:
3791:
3787:
3781:
3778:
3776:
3773:
3771:
3768:
3766:
3763:
3761:
3758:
3756:
3753:
3751:
3748:
3746:
3743:
3741:
3738:
3736:
3733:
3731:
3728:
3726:
3723:
3721:
3718:
3716:
3713:
3711:
3708:
3706:
3703:
3701:
3698:
3696:
3693:
3691:
3688:
3686:
3683:
3681:
3678:
3676:
3673:
3671:
3668:
3666:
3663:
3661:
3658:
3656:
3653:
3651:
3648:
3646:
3643:
3641:
3638:
3636:
3633:
3631:
3630:Nortetrazepam
3628:
3626:
3623:
3621:
3618:
3616:
3613:
3611:
3608:
3606:
3603:
3601:
3598:
3596:
3593:
3591:
3588:
3586:
3583:
3581:
3578:
3576:
3573:
3571:
3568:
3566:
3563:
3561:
3558:
3556:
3553:
3551:
3548:
3546:
3543:
3541:
3538:
3536:
3533:
3531:
3528:
3526:
3523:
3521:
3518:
3516:
3513:
3511:
3508:
3506:
3503:
3501:
3498:
3496:
3493:
3491:
3490:Flutoprazepam
3488:
3486:
3483:
3481:
3478:
3476:
3473:
3471:
3470:Flunitrazolam
3468:
3466:
3465:Flunitrazepam
3463:
3461:
3458:
3456:
3455:Flubromazolam
3453:
3451:
3450:Flubromazepam
3448:
3446:
3443:
3441:
3438:
3436:
3433:
3431:
3428:
3426:
3423:
3421:
3418:
3416:
3413:
3411:
3408:
3406:
3403:
3401:
3398:
3396:
3393:
3391:
3388:
3386:
3383:
3381:
3378:
3376:
3373:
3371:
3368:
3366:
3363:
3361:
3358:
3356:
3353:
3351:
3350:Cloniprazepam
3348:
3346:
3343:
3341:
3338:
3336:
3333:
3331:
3328:
3326:
3323:
3321:
3318:
3316:
3313:
3311:
3308:
3306:
3303:
3301:
3298:
3296:
3293:
3291:
3288:
3286:
3283:
3281:
3278:
3276:
3273:
3271:
3268:
3266:
3263:
3261:
3258:
3256:
3253:
3251:
3248:
3246:
3243:
3241:
3240:2-Oxoquazepam
3238:
3237:
3235:
3233:
3229:
3223:
3220:
3218:
3215:
3213:
3210:
3208:
3205:
3203:
3200:
3198:
3195:
3193:
3190:
3188:
3185:
3183:
3182:Thialbarbital
3180:
3178:
3177:Tetrabarbital
3175:
3173:
3170:
3168:
3165:
3163:
3162:Spirobarbital
3160:
3158:
3155:
3153:
3150:
3148:
3145:
3143:
3142:Proxibarbital
3140:
3138:
3135:
3133:
3132:Propallylonal
3130:
3128:
3125:
3123:
3120:
3118:
3115:
3113:
3112:Phenobarbital
3110:
3108:
3105:
3103:
3102:Pentobarbital
3100:
3098:
3095:
3093:
3092:Narcobarbital
3090:
3088:
3085:
3083:
3080:
3078:
3075:
3073:
3070:
3068:
3065:
3063:
3060:
3058:
3057:Heptobarbital
3055:
3053:
3050:
3048:
3045:
3043:
3040:
3038:
3035:
3033:
3030:
3028:
3027:Difebarbamate
3025:
3023:
3020:
3018:
3017:Cyclobarbital
3015:
3013:
3010:
3008:
3005:
3003:
3000:
2998:
2995:
2993:
2990:
2988:
2985:
2983:
2980:
2978:
2975:
2973:
2970:
2968:
2965:
2963:
2962:Benzobarbital
2960:
2958:
2955:
2953:
2950:
2948:
2945:
2943:
2940:
2938:
2935:
2933:
2930:
2928:
2925:
2924:
2922:
2920:
2916:
2910:
2907:
2905:
2902:
2900:
2897:
2895:
2892:
2890:
2888:
2884:
2882:
2880:
2876:
2874:
2871:
2869:
2866:
2864:
2861:
2859:
2856:
2854:
2851:
2849:
2846:
2844:
2841:
2839:
2836:
2834:
2833:Ethchlorvynol
2831:
2828:
2824:
2821:
2819:
2816:
2814:
2811:
2809:
2806:
2804:
2801:
2800:
2798:
2796:
2792:
2788:
2775:
2770:
2768:
2763:
2761:
2756:
2755:
2752:
2736:
2734:
2731:
2730:
2728:
2725:
2722:
2719:
2717:
2714:
2713:
2709:
2699:
2696:
2694:
2691:
2689:
2682:
2680:
2678:
2674:
2671:
2667:
2663:
2662:neurosteroids
2660:
2657:
2655:
2648:
2647:
2644:
2640:Miscellaneous
2637:
2633:
2618:
2617:levothyroxine
2610:
2606:
2603:
2600:
2596:
2592:
2589:
2587:
2584:
2581:
2577:
2573:
2569:
2565:
2564:brexpiprazole
2561:
2557:
2554:
2553:
2550:
2546:
2541:
2537:
2523:
2520:
2519:Irreversible:
2517:
2516:
2514:
2508:
2499:
2493:
2490:
2488:
2485:
2483:
2480:
2478:
2475:
2473:
2470:
2468:
2465:
2463:
2460:
2457:
2456:
2454:
2448:
2439:
2433:
2430:
2427:
2426:
2423:
2420:
2417:
2416:
2413:
2410:
2408:
2405:
2403:
2400:
2398:
2395:
2393:
2390:
2388:
2385:
2383:
2380:
2378:
2375:
2373:
2370:
2368:
2365:
2363:
2360:
2358:
2355:
2353:
2352:Isocarboxazid
2350:
2348:
2345:
2343:
2340:
2338:
2335:
2334:Irreversible:
2332:
2331:
2329:
2327:Non-selective
2325:
2321:
2317:
2312:
2308:
2294:
2291:
2290:
2288:
2284:
2278:
2275:
2273:
2270:
2268:
2265:
2263:
2260:
2259:
2257:
2252:
2246:
2240:
2237:
2235:
2232:
2230:
2227:
2225:
2224:Protriptyline
2222:
2220:
2217:
2215:
2212:
2210:
2207:
2205:
2202:
2200:
2199:Nortriptyline
2197:
2195:
2194:Nitroxazepine
2192:
2190:
2187:
2185:
2182:
2180:
2177:
2175:
2172:
2170:
2167:
2165:
2162:
2160:
2157:
2155:
2152:
2150:
2147:
2145:
2142:
2140:
2137:
2135:
2134:Demexiptiline
2132:
2130:
2127:
2125:
2122:
2120:
2117:
2115:
2112:
2110:
2109:Amitriptyline
2107:
2105:
2102:
2101:
2099:
2094:
2088:
2084:
2080:
2076:
2071:
2067:
2053:
2050:
2048:
2045:
2043:
2040:
2038:
2035:
2033:
2030:
2028:
2025:
2023:
2020:
2018:
2015:
2013:
2010:
2008:
2005:
2003:
2000:
1998:
1995:
1993:
1990:
1988:
1985:
1983:
1980:
1978:
1975:
1974:
1972:
1968:
1962:
1959:
1957:
1954:
1953:
1951:
1946:
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1934:
1931:
1929:
1926:
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1868:
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1835:
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1814:
1808:
1802:
1799:
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1402:
1396:
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1256:
1252:
1248:
1244:
1240:
1233:
1231:
1214:
1210:
1206:
1200:
1198:
1190:
1189:public domain
1171:
1169:
1163:
1157:
1155:
1153:
1151:
1149:
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1145:
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1125:
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1069:
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1055:
1051:
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1043:
1039:
1032:
1030:
1021:
1017:
1013:
1009:
1004:
999:
995:
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987:
983:
979:
968:
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953:
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928:
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877:
867:
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860:
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854:
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847:
843:
839:
829:
827:
817:
814:
813:
806:
796:
792:
788:
778:
775:
774:boxed warning
770:
762:
760:
756:
746:
744:
739:
737:
729:
725:
722:
719:
716:
715:orally active
712:
708:
704:
700:
696:
692:
688:
683:
681:
677:
673:
669:
655:
650:
649:
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619:
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605:
602:
597:
590:
588:
584:
557:
555:
551:
546:
542:
538:
535:
533:
531:ECHA InfoCard
527:
520:
519:ChEMBL4105630
516:
515:
513:
511:
507:
500:
496:
495:
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491:
487:
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280:
278:
274:
270:
268:
264:
260:
256:
250:
240:
239:
237:
235:
231:
226:
219:
218:
216:
214:
210:
207:
199:
196:
194:
190:
187:
184:
182:
176:
169:
168:
166:
164:
158:
151:
146:
137:
136:
134:
132:
128:
124:
120:
116:
114:
110:
106:
105:
94:
56:
54:Pronunciation
52:
49:Clinical data
47:
43:
38:
30:
19:
5420:5β-Pregnanes
5361:
5360:
5331:
5188:Lavender oil
4930:Nitric oxide
4850:Cryofluorane
4795:Acetophenone
4753:Methaqualone
4748:Mecloqualone
4743:Mebroqualone
4733:Diproqualone
4728:Cloroqualone
4657:Glutethimide
4461:
4413:
4380:
4342:
4324:
4315:Testosterone
4280:Progesterone
4245:Hydroxydione
4194:Androsterone
4121:Acecarbromal
4026:constituents
3813:Cyclarbamate
3803:Carisoprodol
3575:Metaclazepam
3570:Menitrazepam
3560:Meclonazepam
3555:Lormetazepam
3485:Flutemazepam
3310:Ciclotizolam
3300:Carburazepam
3192:Thiobarbital
3152:Secobarbital
3117:Phetharbital
3097:Nealbarbital
3082:Methohexital
3067:Hexobarbital
3002:Butallylonal
2997:Butobarbital
2952:Barbexaclone
2947:Aprobarbital
2932:Allobarbital
2919:Barbiturates
2886:
2878:
2868:Petrichloral
2684:Oxitriptan (
2676:
2669:
2560:aripiprazole
2518:
2467:Metralindole
2458:
2428:
2418:
2397:Pivhydrazine
2387:Pheniprazine
2333:
2239:Trimipramine
2229:Quinupramine
2129:Clomipramine
2124:Butriptyline
2047:Teniloxazine
2042:Tandospirone
2027:Metryptamine
2022:Medifoxamine
2007:Indeloxazine
1961:Vortioxetine
1723:Escitalopram
1627:
1615:
1571:
1567:
1557:
1522:
1518:
1508:
1475:
1471:
1464:
1454:McKenzie H.
1449:
1437:. Retrieved
1427:
1418:10665/330879
1408:
1404:
1395:
1360:
1356:
1342:
1330:. Retrieved
1319:
1307:
1282:
1278:
1267:
1245:(2): 61–70.
1242:
1238:
1217:. Retrieved
1208:
1174:. Retrieved
1165:
1107:. Retrieved
1045:
1041:
985:
981:
955:
952:"Zuranolone"
931:. Retrieved
926:
917:
888:
873:
861:
850:
835:
832:Legal status
823:
810:
807:
784:
771:
768:
752:
749:Medical uses
740:
724:neurosteroid
687:side effects
684:
671:
667:
666:
499:CHEBI:228302
374:1632051-40-1
352:
348:
344:
340:
336:
332:
328:
324:
320:
316:
287:Elimination
234:Legal status
228:Legal status
198:Neurosteroid
131:License data
29:
5270:Stiripentol
5265:Seproxetine
5235:Niacinamide
5215:Loreclezole
5036:Avermectins
5000:Vinyl ether
4970:Sevoflurane
4950:Paraldehyde
4900:Halopropane
4723:Afloqualone
4705:Tracazolate
4700:ICI-190,622
4690:Cartazolate
4667:Piperidione
4662:Methyprylon
4629:Fospropofol
4551:Pipequaline
4359:Pazinaclone
4349:Eszopiclone
4205:Cholesterol
4189:Androstenol
4113:Monoureides
4093:Methysticin
3893:Tetrabamate
3873:Pentabamate
3863:Meprobamate
3833:Febarbamate
3798:Carisbamate
3750:Triflubazam
3740:Tolufazepam
3700:Rilmazafone
3695:Remimazolam
3670:Proflazepam
3655:Pivoxazepam
3615:Nitrazepate
3605:Nimetazepam
3540:Lopirazepam
3510:Haloxazolam
3460:Fludiazepam
3405:Doxefazepam
3380:Delorazepam
3360:Clotiazepam
3355:Clorazepate
3320:Cinolazepam
3217:Vinbarbital
3172:Tetrabamate
3127:Probarbital
3107:Phenallymal
3072:Metharbital
3047:Febarbamate
2942:Amobarbital
2843:Isopropanol
2813:Chloralodol
2723:from market
2666:brexanolone
2580:risperidone
2477:Moclobemide
2459:Reversible:
2419:Reversible:
2342:Iproclozide
2277:Setiptiline
2272:Mirtazapine
2262:Maprotiline
2219:Propizepine
2204:Noxiptiline
2189:Metapramine
2179:Lofepramine
2149:Dimetacrine
2139:Desipramine
2012:Flupentixol
1997:Etryptamine
1982:Amisulpride
1977:Agomelatine
1923:Etoperidone
1900:Setiptiline
1895:Mirtazapine
1867:Nomifensine
1824:Atomoxetine
1801:Venlafaxine
1791:Milnacipran
1733:Fluvoxamine
1629:NCT02978326
1617:NCT04442503
1277:Receptor".
1219:10 February
1209:AdisInsight
787:brexanolone
594: g·mol
537:100.271.331
299:Identifiers
294:16–23 hours
249:Schedule IV
122:Other names
113:Trade names
5409:Categories
5303:Topiramate
5293:Terpenoids
5250:Propanidid
5240:Org 25,435
5168:Flupirtine
5163:Fluoxetine
5069:Chloralose
5040:ivermectin
4945:Norflurane
4910:Isoflurane
4855:Desflurane
4845:Chloroform
4805:Aliflurane
4738:Etaqualone
4566:SB-205,384
4496:CP-615,003
4491:CL-218,872
4445:Panadiplon
4435:Lorediplon
4364:Suproclone
4325:Zuranolone
4285:Renanolone
4270:Posovolone
4250:Minaxolone
4240:Ganaxolone
4179:Alfaxalone
4174:Alfadolone
4164:Acebrochol
4131:Bromisoval
4009:Metomidate
3996:Imidazoles
3956:Hispidulin
3908:Flavonoids
3868:Nisobamate
3858:Mebutamate
3828:Ethinamate
3823:Emylcamate
3790:Carbamates
3760:Tuclazepam
3735:Tetrazepam
3690:Reclazepam
3665:Premazepam
3645:Phenazepam
3625:Nordazepam
3620:Nitrazolam
3610:Nitrazepam
3590:Motrazepam
3545:Loprazolam
3535:Lofendazam
3520:Imidazenil
3480:Flutazolam
3475:Flurazepam
3445:Fletazepam
3400:Dimdazenil
3395:Diclazepam
3375:Cyprazepam
3365:Cloxazolam
3345:Clonazolam
3340:Clonazepam
3330:Climazolam
3290:Brotizolam
3285:Bromazolam
3280:Bromazepam
3275:Bretazenil
3270:Bentazepam
3260:Arfendazam
3255:Alprazolam
3250:Adinazolam
3222:Vinylbital
3202:Thiopental
3077:Methitural
2992:Buthalital
2987:Butalbital
2838:Isobutanol
2698:Tryptophan
2670:zuranolone
2576:quetiapine
2572:olanzapine
2568:lurasidone
2522:Selegiline
2512:-selective
2492:Toloxatone
2487:Tetrindole
2482:Pirlindole
2462:Eprobemide
2452:-selective
2432:Bifemelane
2422:Caroxazone
2382:Phenelzine
2367:Mebanazine
2347:Iproniazid
2234:Tianeptine
2214:Pipofezine
2184:Melitracen
2164:Imipramine
2144:Dibenzepin
2104:Amineptine
2052:Tianeptine
2037:Pivagabine
2032:Oxaflozane
1992:Esketamine
1956:Vilazodone
1928:Nefazodone
1857:Amineptine
1834:Viloxazine
1829:Reboxetine
1781:Duloxetine
1753:Zimelidine
1748:Sertraline
1743:Paroxetine
1728:Fluoxetine
1718:Citalopram
1574:: 117277.
1363:: 108333.
1205:"SAGE 217"
988:: 108035.
978:receptors"
909:References
846:fast track
718:inhibitory
691:drowsiness
668:Zuranolone
599:3D model (
587:Molar mass
459:7ZW49N180B
430:ChemSpider
365:CAS Number
308:IUPAC name
277:Metabolism
193:Drug class
150:Zuranolone
34:Zuranolone
5460:Pyrazoles
5362:See also:
5324:valerenol
5245:Phenytoin
5225:Monastrol
5183:Lanthanum
5178:KRM-II-81
5141:Fenamates
5136:Etifoxine
5131:Etazepine
5126:Efavirenz
5084:Darigabat
4980:Teflurane
4965:Roflurane
4960:Propylene
4905:Halothane
4890:Fluroxene
4875:Enflurane
4778:Volatiles
4695:Etazolate
4606:Viqualine
4561:RWJ-51204
4526:L-838,417
4516:Imepitoin
4486:CGS-20625
4481:CGS-13767
4466:Adipiplon
4440:Ocinaplon
4402:Saripidem
4397:Necopidem
4374:Zopiclone
4369:Suriclone
4354:Pagoclone
4260:ORG-21465
4255:ORG-20599
4146:Ectylurea
4136:Carbromal
4014:Propoxate
4004:Etomidate
3931:Baicalein
3888:Styramate
3883:Procymate
3853:Lorbamate
3838:Felbamate
3808:Clocental
3780:Zomebazam
3775:Zolazepam
3770:Zapizolam
3765:Uldazepam
3745:Triazolam
3730:Temazepam
3725:Sulazepam
3715:Ro48-8684
3710:Ro48-6791
3705:Ripazepam
3675:Pyrazolam
3650:Pinazepam
3600:Nifoxipam
3585:Midazolam
3580:Mexazolam
3565:Medazepam
3550:Lorazepam
3530:Ketazolam
3525:Irazepine
3515:Iclazepam
3505:Halazepam
3500:Gidazepam
3495:Fosazepam
3415:Estazolam
3410:Elfazepam
3385:Demoxepam
3315:Cinazepam
3295:Camazepam
3265:Avizafone
3187:Thiamylal
3122:Primidone
3052:Heptabarb
3042:Eterobarb
3007:Carbubarb
2904:Triclofos
2803:Brometone
2733:Phase III
2721:Withdrawn
2586:Buspirone
2472:Minaprine
2407:Tedizolid
2402:Safrazine
2377:Octamoxin
2372:Nialamide
2362:Linezolid
2357:Isoniazid
2267:Mianserin
2209:Opipramol
2174:Iprindole
2154:Dosulepin
2119:Amoxapine
2075:Tricyclic
1933:Trazodone
1890:Mianserin
1862:Bupropion
1796:Tofenacin
1738:Indalpine
1687:Specific
1598:229333842
1500:258461851
1020:244280839
755:indicated
695:dizziness
289:half-life
179:Routes of
161:Pregnancy
5455:Nitriles
5425:Alcohols
5399:Medicine
5350:TCS-1205
5345:TCS-1105
5335:α-Pinene
5308:Valerian
5283:tetronal
5260:Safranal
5209:obovatol
5205:magnolol
5201:honokiol
5031:Alogabat
5026:AA-29504
4975:Synthane
4935:Nitrogen
4915:Kerosine
4895:Gasoline
4885:Ethylene
4825:Centalun
4820:Butylene
4634:Propofol
4596:U-89843A
4576:TGSC01AA
4546:NS-11394
4511:GBLD-345
4476:CGS-9896
4471:CGS-8216
4455:Zaleplon
4450:Taniplon
4430:Indiplon
4425:Fasiplon
4420:Divaplon
4407:Zolpidem
4310:SAGE-872
4305:SAGE-689
4300:SAGE-516
4295:SAGE-324
4290:SAGE-105
4198:Certain
4141:Capuride
4103:Yangonin
3980:baicalin
3976:Skullcap
3966:Luteolin
3941:Catechin
3936:Baicalin
3926:Apigenin
3898:Tybamate
3685:Quazepam
3680:QH-II-66
3660:Prazepam
3640:Oxazolam
3635:Oxazepam
3435:Etizolam
3390:Diazepam
3370:CP-1414S
3335:Clobazam
3325:Clazolam
3212:Valofane
3167:Talbutal
3157:Sigmodal
3062:Hexethal
2957:Barbital
2937:Alphenal
2927:(-)-DMBB
2873:Propanol
2863:Pentanol
2853:Methanol
2795:Alcohols
2659:GABAkine
2337:Benmoxin
2293:Tiazesim
2017:Ketamine
2002:Gepirone
1590:33387701
1549:34190962
1492:37132201
1439:4 August
1387:32976892
1332:5 August
1326:Archived
1299:28753313
1259:29223589
1213:Archived
1176:4 August
1109:5 August
1100:Archived
1072:33224470
1012:34793859
891:insomnia
870:Research
736:receptor
721:pregnane
699:diarrhea
689:include
680:by mouth
672:Zurzuvae
439:71117610
410:DrugBank
399:86294073
315:1-(2-((3
213:ATC code
186:By mouth
163:category
145:DailyMed
117:Zurzuvae
18:Zurzuvae
5445:Ketones
5297:borneol
5295:(e.g.,
5287:trional
5277:(e.g.,
5195:(e.g.,
5193:Lignans
5143:(e.g.,
5101:(e.g.,
5046:Bromide
5038:(e.g.,
5021:α-EMTBL
4985:Toluene
4955:Propane
4830:Chloral
4810:Benzene
4790:Acetone
4621:Phenols
4611:Y-23684
4601:U-90042
4586:TPA-023
4571:SX-3228
4556:ROD-188
4541:NS-2710
4536:NS-2664
4521:JM-1232
4506:ELB-139
4501:CTP-354
4387:Alpidem
3986:Wogonin
3961:Linarin
3440:FG-8205
3147:Reposal
2848:Menthol
2808:Butanol
2591:Lithium
2159:Doxepin
1691:and/or
1540:8246337
1378:8265595
1063:7656877
1003:9787737
933:5 March
781:History
730:of the
703:fatigue
592:409.574
554:Formula
419:DB15490
385:PubChem
147::
104:-ə-lohn
5385:Portal
5230:Niacin
4815:Butane
4768:SL-164
4639:Thymol
4581:TP-003
4462:Others
4265:P1-185
4225:5β-DHP
4220:5α-DHP
4215:3α-DHP
4063:Kavain
3971:Rc-OMe
2716:WHO-EM
2429:Mixed:
2286:Others
1970:Others
1878:NaSSAs
1596:
1588:
1547:
1537:
1498:
1490:
1385:
1375:
1297:
1257:
1070:
1060:
1018:
1010:
1000:
901:, and
803:
799:
793:and a
743:Biogen
709:, and
625:SMILES
510:ChEMBL
479:D11793
281:CYP3A4
247:
143:
107:
5089:DEABL
4782:gases
4591:TP-13
4320:THDOC
4210:DHDOC
2686:5-HTP
2250:TeCAs
1911:SARIs
1845:NDRIs
1764:SNRIs
1706:SSRIs
1594:S2CID
1496:S2CID
1411:(3).
1170:(FDA)
1166:U.S.
1103:(PDF)
1096:(PDF)
1016:S2CID
884:HAM-D
713:. An
645:InChI
601:JSmol
490:ChEBI
271:99.5%
4392:DS-1
4024:Kava
3951:EGCG
2887:tert
2879:tert
2782:GABA
2652:SAMe
2092:TCAs
2077:and
1812:NRIs
1674:N06A
1586:PMID
1545:PMID
1488:PMID
1441:2023
1383:PMID
1334:2023
1295:PMID
1255:PMID
1221:2018
1178:2023
1111:2023
1068:PMID
1008:PMID
935:2024
844:and
732:GABA
470:KEGG
450:UNII
261:data
220:None
202:GABA
100:zuu-
5121:DS2
4230:DHT
3946:EGC
2615:),
2503:MAO
2443:MAO
1944:SMS
1576:doi
1572:421
1535:PMC
1527:doi
1480:doi
1476:180
1413:hdl
1373:PMC
1365:doi
1361:181
1287:doi
1247:doi
1058:PMC
1050:doi
998:PMC
990:doi
986:234
389:CID
343:,17
339:,14
335:,13
331:,10
102:RAN
5411::
5371:•
5367:•
5322:,
5318:,
5314:,
5285:,
5281:,
5207:,
5203:,
5199:,
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5113:,
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5056:,
5052:,
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2668:,
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2619:(T
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