805:
approximately equal to 40 mg of zuranolone or placebo, also for 14 days. Participants in both studies were monitored for at least four weeks after the 14-day treatment. The primary endpoint of both studies was the change in depressive symptoms using the total score from the 17-item
Hamilton depression rating scale (HAMD-17), measured at day 15. Participants in the zuranolone groups showed significantly more improvement in their symptoms compared to those in the placebo groups. The treatment effect was maintained at day 42—four weeks after the last dose of zuranolone.
530:
31:
5383:
1173:
599:
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criteria for a major depressive episode and whose symptoms began in the third trimester or within four weeks of delivery. In study 1, participants received 50 mg of zuranolone or placebo once daily in the evening for 14 days. In study 2, participants received another zuranolone product that was
1261:
Martinez
Botella G, Salituro FG, Harrison BL, Beresis RT, Bai Z, Blanco MJ, et al. (2017). "Neuroactive Steroids. 2. 3α-Hydroxy-3β-methyl-21-(4-cyano-1H-pyrazol-1'-yl)-19-nor-5β-pregnan-20-one (SAGE-217): A Clinical Next Generation Neuroactive Steroid Positive Allosteric Modulator of the
1421:
797:
The efficacy of zuranolone for the treatment of postpartum depression in adults was demonstrated in two randomized, double-blind, placebo-controlled, multicenter studies. The trial participants were women with postpartum depression who met the
5109:
765:
noting that zuranolone can impact a person's ability to drive and perform other potentially hazardous activities. The use of zuranolone may cause suicidal thoughts and behavior. Zuranolone may also cause fetal harm.
1458:
Clayton AH, Lasser R, Parikh SV, Iosifescu DV, Jung J, Kotecha M, et al. (May 2023). "Zuranolone for the
Treatment of Adults With Major Depressive Disorder: A Randomized, Placebo-Controlled Phase 3 Trial".
5009:
3959:
871:, subjects in the zuranolone group (50 mg oral zuranolone once daily for 14 days) experienced statistically significant and sustained improvements in depressive symptoms (as measured by
641:
InChI=1S/C25H35N3O2/c1-24(30)9-7-18-17(11-24)3-4-20-19(18)8-10-25(2)21(20)5-6-22(25)23(29)15-28-14-16(12-26)13-27-28/h13-14,17-22,30H,3-11,15H2,1-2H3/t17-,18+,19-,20-,21+,22-,24-,25+/m1/s1
4041:
1422:"FDA Approves Zurzuvae (zuranolone), the First and Only Oral Treatment Approved for Women with Postpartum Depression, and Issues a Complete Response Letter for Major Depressive Disorder"
911:
4071:
2760:
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Zuranolone was approved for medical use in the United States for the treatment of postpartum depression in August 2023. It was developed by Sage
Therapeutics and
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1226:
Blanco MJ, La D, Coughlin Q, Newman CA, Griffin AM, Harrison BL, et al. (2018). "Breakthroughs in neuroactive steroid drug discovery".
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2746:
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5019:
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4489:
3949:
1649:
1088:
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1201:
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for "A Study to
Evaluate the Efficacy and Safety of SAGE-217 in Participants With Severe Postpartum Depression (PPD)" at
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237:
138:
5357:
4788:
814:
706:
633:
87:
963:"GABAkines - Advances in the discovery, development, and commercialization of positive allosteric modulators of GABA
2721:
1303:
296:
222:
119:
829:(FDA) for the treatment of postpartum depression in August 2023. The FDA granted the application for zuranolone
4308:
1642:
716:
1392:(2019). "International nonproprietary names for pharmaceutical substances (INN): recommended INN: list 82".
1027:"Intravenous brexanolone for postpartum depression: what it is, how well does it work, and will it be used?"
758:
The most common side effects include drowsiness, dizziness, diarrhea, fatigue, and urinary tract infection.
5353:
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826:
525:
438:
507:
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1502:
Deligiannidis KM, Meltzer-Brody S, Gunduz-Bruce H, Doherty J, Jonas J, Li S, et al. (2021).
699:
167:
101:
1553:"Zuranolone as an oral adjunct to treatment of Parkinsonian tremor: A phase 2, open-label study"
5438:
2955:
2544:
2015:
1082:"Zurzuvae (zuranolone) capsules, for oral use, [controlled substance schedule pending]"
891:
487:
255:
427:
5300:
4978:
1985:
747:
664:
362:
1338:"Preclinical characterization of zuranolone (SAGE-217), a selective neuroactive steroid GABA
5082:
3708:
3583:
2664:
2579:
783:
447:
275:
4172:
774:
Zuranolone was developed as an improvement on the intravenously administered neurosteroid
529:
8:
5208:
5091:
4218:
4144:
3233:
3075:
2783:
2490:
2430:
703:
668:
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for "A Study to
Evaluate SAGE-217 in Participants With Severe Postpartum Depression" at
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5185:
4848:
4746:
4403:
4036:
3408:
3010:
1681:
1677:
1622:
1610:
1582:
1528:
1504:"Effect of Zuranolone vs Placebo in Postpartum Depression: A Randomized Clinical Trial"
1503:
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1336:
Althaus AL, Ackley MA, Belfort GM, Gee SM, Dai J, Nguyen DP, et al. (2020).
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912:"Schedules of Controlled Substances: Placement of Zuranolone in Schedule IV"
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22:
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designations. Approval of
Zurzuvae was granted to Sage Therapeutics, Inc.
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suitable for once-daily administration. Its half-life is around 16 to 23
407:
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2020:
1980:
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1731:
1716:
1706:
1445:"Sage Hints at Difficult Decisions After Zuranolone's Rejection in MDD"
1304:"FDA approves postpartum depression pill from two Cambridge drug firms"
1260:
961:
Cerne R, Lippa A, Poe MM, Smith JL, Jin X, Ping X, et al. (2022).
679:
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743:
683:
373:
1899:
1752:
875:
score) throughout the treatment and follow-up periods of the study.
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2005:
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2147:
1176:
This article incorporates text from this source, which is in the
848:(CRL) by the FDA due to insufficient evidence of effectiveness.
840:
Zuranolone has also been under development for the treatment of
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5181:
4803:
4756:
4627:
4609:
4569:
4253:
4051:
1871:
1694:
1551:
Bullock A, Kaul I, Li S, Silber C, Doherty J, Kanes SJ (2021).
731:
498:
4579:
2062:
1151:"FDA Approves First Oral Treatment for Postpartum Depression"
589:
478:
30:
1457:
4012:
1932:
458:
75:
69:
1800:
54:
1388:
904:
63:
1335:
867:
to assess its efficacy and safety for the treatment of
2768:
1225:
621:
O=C(CN1N=CC(C#N)=C1)2CC3()4()CC5()C(C)(O)CC5()4()CC32C
5371:
801:
88:
78:
66:
51:
1904:
Tooltip
Serotonin antagonist and reuptake inhibitors
1757:
Tooltip Serotonin–norepinephrine reuptake inhibitors
1076:
1074:
1072:
1070:
72:
60:
2238:
1838:
Tooltip Norepinephrine–dopamine reuptake inhibitors
1550:
57:
1302:
1145:
1143:
1141:
1139:
1137:
1135:
1133:
1131:
1129:
960:
5321:Unsorted benzodiazepine site positive modulators:
2080:
1495:
1127:
1125:
1123:
1121:
1119:
1117:
1115:
1113:
1111:
1109:
1067:
5395:
2303:
386:
2640:
1699:Tooltip Selective serotonin reuptake inhibitors
844:, but the application for this use was given a
361:
1106:
5429:GABAA receptor positive allosteric modulators
2754:
1643:
1188:
1186:
1436:
1228:Bioorganic & Medicinal Chemistry Letters
1221:
1219:
1024:
663:, is a medication used for the treatment of
137:
2770:
2674:
2491:
2431:
1937:Tooltip Serotonin modulator and stimulators
1544:
1451:
1329:
1020:
1018:
956:
954:
878:Other investigational applications include
340:-cyclopentaphenanthren-17-yl)-2-oxoethyl)-1
2761:
2747:
1805:Tooltip Norepinephrine reuptake inhibitors
1657:
1650:
1636:
1424:(Press release). Biogen Inc. 4 August 2023
1254:
1183:
1031:Therapeutic Advances in Psychopharmacology
528:
426:
1568:
1527:
1405:
1365:
1216:
1050:
990:
446:
16:Medication used for postpartum depression
2532:
1300:
1015:
951:
336:)-3-Hydroxy-3,13-dimethylhexadecahydro-1
1342:receptor positive allosteric modulator"
406:
5396:
935:
933:
851:In the United States, zuranolone is a
808:
519:
195:receptor positive allosteric modulator
2742:
2627:
2531:
2302:
2061:
1674:
1631:
506:
486:
231:
128:
114:SAGE-217; S-812217; SGE-797; BIIB-125
5362:GABA metabolism/transport modulators
1557:Journal of the Neurological Sciences
1442:
863:In a randomized, placebo-controlled
4979:Trichloroethane (methyl chloroform)
2243:Tooltip Tetracyclic antidepressants
930:
466:
377:
13:
4042:11-Methoxy-12-hydroxydehydrokavain
1461:The American Journal of Psychiatry
1317:from the original on 6 August 2023
1204:from the original on 29 March 2019
1094:from the original on 5 August 2023
825:Zuranolone was approved by the US
790:hours, compared to approximately 9
753:
14:
5460:
4789:Acetylglycinamide chloral hydrate
2628:
2085:Tooltip Tricyclic antidepressants
1597:
815:international nonproprietary name
5381:
1520:10.1001/jamapsychiatry.2021.1559
1358:10.1016/j.neuropharm.2020.108333
1171:
983:10.1016/j.pharmthera.2021.108035
853:Schedule IV controlled substance
559:
553:
47:
29:
5209:Menthyl isovalerate (validolum)
1414:
1382:
1294:
971:Pharmacology & Therapeutics
820:
737:
646:Key:HARRKNSQXBRBGZ-GVKWWOCJSA-N
5404:Drugs not assigned an ATC code
4158:Allopregnanolone (brexanolone)
1268:Journal of Medicinal Chemistry
1161:(Press release). 4 August 2023
565:
547:
1:
5354:Receptor/signaling modulators
3910:Ampelopsin (dihydromyricetin)
897:
717:positive allosteric modulator
5104:ergoloid (dihydroergotoxine)
4189:anabolic-androgenic steroids
2971:Butabarbital/Secbutabarbital
2776:receptor positive modulators
2305:Monoamine oxidase inhibitors
1301:Saltzman J (4 August 2023).
1280:10.1021/acs.jmedchem.7b00846
1157:Food and Drug Administration
827:Food and Drug Administration
761:The US FDA label contains a
659:, sold under the brand name
7:
3744:Triflunordazepam (Ro5-2904)
2499:Tooltip Monoamine oxidase B
2439:Tooltip Monoamine oxidase A
2068:tetracyclic antidepressants
1025:Faden J, Citrome L (2020).
858:
10:
5465:
4072:5,6,7,8-Tetrahydroyangonin
1976:Dextromethorphan/bupropion
1432:– via GlobeNewswire.
1240:10.1016/j.bmcl.2017.11.043
769:
537:Chemical and physical data
5347:
4997:
4765:
4702:
4669:
4636:
4608:
4322:
4264:Pregnanolone (eltanolone)
4143:
4100:
4011:
3983:
3895:
3777:
3219:
2906:
2807:Chlorobutanol (cloretone)
2782:
2699:
2634:
2623:
2540:
2527:
2489:
2429:
2315:
2311:
2298:
2274:
2236:
2078:
2074:
2057:
1958:
1930:
1897:
1864:
1831:
1798:
1750:
1692:
1688:
1670:
1570:10.1016/j.jns.2020.117277
1473:10.1176/appi.ajp.20220459
1390:World Health Organization
869:major depressive disorder
842:major depressive disorder
629:
609:
587:
574:
541:
536:
517:
497:
477:
457:
437:
417:
397:
372:
352:
292:
287:
274:
264:
254:
246:
221:
216:
200:
180:
166:
148:
118:
110:
100:
42:
37:
28:
5358:GABA receptor modulators
5268:sulfonmethane (sulfonal)
2682:Rubidium chloride (RbCl)
1043:10.1177/2045125320968658
846:Complete Response Letter
344:-pyrazole-4-carbonitrile
2545:Atypical antipsychotics
794:hours for brexanolone.
715:, zuranolone acts as a
700:urinary tract infection
5244:Retigabine (ezogabine)
4520:Lirequinil (Ro41-3696)
4087:7,8-Dihydromethysticin
4077:5,6-Dehydromethysticin
2956:Benzylbutylbarbiturate
1615:Clinical trial number
1603:Clinical trial number
1262:(γ-Aminobutyric Acid)
748:postpartum depression
746:for the treatment of
665:postpartum depression
5299:constituents (e.g.,
5083:Deuterated etifoxine
4145:Neuroactive steroids
4115:Apronal (apronalide)
3967:constituents (e.g.,
3584:N-Desalkylflurazepam
2666:Hypericum perforatum
2534:Adjunctive therapies
1394:WHO Drug Information
1037:: 2045125320968658.
784:biological half-life
5092:dihydroergocryptine
4404:Pyrazolopyrimidines
4062:5,6-Dihydroyangonin
4047:7,8-Dihydroyangonin
3234:3-Hydroxyphenazepam
3076:Methylphenobarbital
1682:receptor modulators
1678:reuptake inhibitors
892:Parkinson's disease
809:Society and culture
25:
5186:4-O-methylhonokiol
4849:Dichloralphenazone
4747:Methylmethaqualone
4324:Nonbenzodiazepines
4037:Desmethoxyyangonin
4032:11-Hydroxyyangonin
4027:11-Methoxyyangonin
4022:10-Methoxyyangonin
3409:Ethyl carfluzepate
3011:Cyclopentobarbital
2726:Never to phase III
1623:ClinicalTrials.gov
1611:ClinicalTrials.gov
884:bipolar depression
813:Zuranolone is the
21:
5369:
5368:
5329:MRK-409 (MK-0343)
5100:dihydroergotamine
5043:potassium bromide
5037:compounds (e.g.,
4984:Trichloroethylene
4752:Nitromethaqualone
4671:Pyrazolopyridines
4173:3α-Androstanediol
4067:7,8-Dihydrokavain
3419:Ethyl loflazepate
3196:Thiotetrabarbital
2812:Ethanol (alcohol)
2736:
2735:
2695:
2694:
2668:(St. John's Wort)
2619:
2618:
2584:lithium carbonate
2523:
2522:
2519:
2518:
2294:
2293:
2290:
2289:
2103:Amitriptylinoxide
2053:
2052:
2049:
2048:
1346:Neuropharmacology
1274:(18): 7810–7819.
918:. 31 October 2023
778:, with high oral
654:
653:
600:Interactive image
235:
131:
5456:
5386:
5385:
5384:
5377:
5088:Dihydroergolines
5005:3-Hydroxybutanal
4638:Piperidinediones
4371:Imidazopyridines
3905:6-Methylapigenin
3837:Hydroxyphenamate
3709:SH-053-R-CH3-2′F
3414:Ethyl dirazepate
3294:Chlordiazepoxide
3186:Thiobutabarbital
2898:Trifluoroethanol
2888:Trichloroethanol
2878:-Pentanol (2M2B)
2772:
2763:
2756:
2749:
2740:
2739:
2676:
2642:
2625:
2624:
2598:triiodothyronine
2594:Thyroid hormones
2529:
2528:
2500:
2496:
2440:
2436:
2381:Phenoxypropazine
2313:
2312:
2300:
2299:
2244:
2240:
2086:
2082:
2076:
2075:
2059:
2058:
1938:
1934:
1905:
1901:
1872:
1868:
1839:
1835:
1806:
1802:
1758:
1754:
1700:
1696:
1690:
1689:
1672:
1671:
1652:
1645:
1638:
1629:
1628:
1591:
1590:
1572:
1548:
1542:
1541:
1531:
1499:
1493:
1492:
1455:
1449:
1448:
1440:
1434:
1433:
1431:
1429:
1418:
1412:
1411:
1409:
1386:
1380:
1379:
1369:
1333:
1327:
1326:
1324:
1322:
1310:The Boston Globe
1306:
1298:
1292:
1291:
1258:
1252:
1251:
1223:
1214:
1213:
1211:
1209:
1190:
1181:
1175:
1174:
1170:
1168:
1166:
1147:
1104:
1103:
1101:
1099:
1093:
1086:
1078:
1065:
1064:
1054:
1022:
1013:
1012:
994:
958:
949:
948:
937:
928:
927:
925:
923:
916:Federal Register
908:
888:essential tremor
793:
789:
674:The most common
602:
582:
567:
561:
555:
549:
532:
521:
510:
490:
470:
450:
430:
410:
390:
380:
379:
365:
279:
233:
230:
141:
130:
127:
92:
85:
84:
81:
80:
77:
74:
71:
68:
65:
62:
59:
56:
53:
33:
26:
24:
20:
5464:
5463:
5459:
5458:
5457:
5455:
5454:
5453:
5424:Antidepressants
5419:Anticonvulsants
5394:
5393:
5392:
5382:
5380:
5372:
5370:
5365:
5343:
5301:isovaleric acid
5264:Sulfonylalkanes
5162:Hopantenic acid
5146:tolfenamic acid
5134:flufenamic acid
5096:dihydroergosine
5039:lithium bromide
4998:Others/unsorted
4993:
4854:Dichloromethane
4829:Chloral hydrate
4824:Chloral betaine
4761:
4698:
4665:
4632:
4604:
4333:Cyclopyrrolones
4318:
4224:Etiocholanolone
4139:
4096:
4057:5-Hydroxykavain
4007:
3979:
3891:
3773:
3221:Benzodiazepines
3215:
3026:Ethallobarbital
3021:Enallylpropymal
2902:
2883:Tribromoethanol
2870:-Butanol (2M2P)
2816:alcoholic drink
2778:
2775:
2767:
2737:
2732:
2731:
2716:Clinical trials
2691:
2630:
2615:
2611:
2603:
2588:lithium citrate
2536:
2515:
2498:
2495:
2485:
2438:
2435:
2425:
2401:Tranylcypromine
2307:
2286:
2270:
2242:
2232:
2084:
2070:
2045:
1954:
1936:
1926:
1903:
1893:
1870:
1860:
1837:
1827:
1804:
1794:
1775:Levomilnacipran
1756:
1746:
1698:
1684:
1666:
1659:Antidepressants
1656:
1600:
1595:
1594:
1549:
1545:
1508:JAMA Psychiatry
1500:
1496:
1456:
1452:
1441:
1437:
1427:
1425:
1420:
1419:
1415:
1387:
1383:
1341:
1334:
1330:
1320:
1318:
1299:
1295:
1265:
1259:
1255:
1224:
1217:
1207:
1205:
1192:
1191:
1184:
1172:
1164:
1162:
1149:
1148:
1107:
1097:
1095:
1091:
1084:
1080:
1079:
1068:
1023:
1016:
966:
959:
952:
945:DrugBank Online
939:
938:
931:
921:
919:
910:
909:
905:
900:
865:phase III trial
861:
831:priority review
823:
811:
791:
787:
780:bioavailability
772:
756:
754:Adverse effects
740:
724:
696:nasopharyngitis
650:
647:
642:
637:
636:
625:
622:
617:
616:
605:
580:
570:
564:
558:
552:
513:
493:
473:
453:
433:
413:
393:
376:
368:
348:
345:
300:
299:
277:
256:Protein binding
248:Pharmacokinetic
242:
212:
194:
169:
162:
159:Contraindicated
151:
144:
90:
86:
50:
46:
17:
12:
11:
5:
5462:
5452:
5451:
5446:
5441:
5436:
5431:
5426:
5421:
5416:
5411:
5406:
5391:
5390:
5367:
5366:
5348:
5345:
5344:
5342:
5341:
5336:
5331:
5326:
5317:
5316:
5309:valerenic acid
5294:
5289:
5279:
5261:
5256:
5251:
5246:
5241:
5236:
5231:
5226:
5221:
5216:
5211:
5206:
5201:
5179:
5174:
5169:
5164:
5159:
5154:
5149:
5138:mefenamic acid
5127:
5122:
5117:
5112:
5107:
5085:
5080:
5075:
5070:
5065:
5060:
5055:
5050:
5047:sodium bromide
5032:
5022:
5017:
5012:
5007:
5001:
4999:
4995:
4994:
4992:
4991:
4986:
4981:
4976:
4971:
4966:
4961:
4956:
4951:
4946:
4941:
4936:
4931:
4926:
4921:
4916:
4914:Methoxypropane
4911:
4909:Methoxyflurane
4906:
4901:
4896:
4891:
4886:
4881:
4876:
4871:
4869:Ethyl chloride
4866:
4861:
4856:
4851:
4846:
4841:
4836:
4831:
4826:
4821:
4816:
4811:
4806:
4801:
4796:
4791:
4786:
4781:
4775:
4773:
4763:
4762:
4760:
4759:
4754:
4749:
4744:
4739:
4734:
4729:
4724:
4719:
4714:
4708:
4706:
4704:Quinazolinones
4700:
4699:
4697:
4696:
4691:
4686:
4681:
4675:
4673:
4667:
4666:
4664:
4663:
4658:
4653:
4648:
4642:
4640:
4634:
4633:
4631:
4630:
4625:
4620:
4614:
4612:
4606:
4605:
4603:
4602:
4597:
4592:
4587:
4582:
4577:
4572:
4567:
4562:
4557:
4552:
4547:
4542:
4537:
4532:
4527:
4522:
4517:
4512:
4507:
4502:
4497:
4492:
4487:
4482:
4477:
4472:
4467:
4462:
4457:
4447:
4446:
4441:
4436:
4431:
4426:
4421:
4416:
4411:
4399:
4398:
4393:
4388:
4383:
4378:
4366:
4365:
4360:
4355:
4350:
4345:
4340:
4328:
4326:
4320:
4319:
4317:
4316:
4311:
4306:
4301:
4296:
4291:
4286:
4281:
4276:
4271:
4266:
4261:
4256:
4251:
4246:
4241:
4236:
4231:
4226:
4221:
4216:
4211:
4206:
4201:
4196:
4191:
4185:
4180:
4175:
4170:
4165:
4160:
4155:
4149:
4147:
4141:
4140:
4138:
4137:
4132:
4127:
4122:
4117:
4112:
4106:
4104:
4098:
4097:
4095:
4094:
4089:
4084:
4079:
4074:
4069:
4064:
4059:
4054:
4049:
4044:
4039:
4034:
4029:
4024:
4018:
4016:
4009:
4008:
4006:
4005:
4000:
3995:
3989:
3987:
3981:
3980:
3978:
3977:
3972:
3962:
3957:
3952:
3947:
3942:
3937:
3932:
3927:
3922:
3917:
3912:
3907:
3901:
3899:
3893:
3892:
3890:
3889:
3884:
3879:
3874:
3869:
3864:
3859:
3854:
3849:
3844:
3839:
3834:
3829:
3824:
3819:
3814:
3809:
3804:
3799:
3794:
3789:
3783:
3781:
3775:
3774:
3772:
3771:
3766:
3761:
3756:
3751:
3746:
3741:
3736:
3731:
3726:
3721:
3716:
3711:
3706:
3701:
3696:
3691:
3686:
3681:
3676:
3671:
3666:
3661:
3656:
3651:
3646:
3641:
3636:
3631:
3626:
3621:
3616:
3611:
3606:
3601:
3596:
3591:
3586:
3581:
3576:
3571:
3566:
3561:
3556:
3551:
3546:
3541:
3536:
3531:
3526:
3521:
3516:
3511:
3506:
3501:
3496:
3491:
3486:
3481:
3476:
3471:
3466:
3461:
3456:
3451:
3446:
3441:
3436:
3431:
3426:
3421:
3416:
3411:
3406:
3401:
3396:
3391:
3386:
3381:
3376:
3371:
3366:
3361:
3356:
3351:
3346:
3341:
3336:
3331:
3326:
3321:
3316:
3311:
3306:
3301:
3296:
3291:
3286:
3281:
3276:
3271:
3266:
3261:
3256:
3251:
3246:
3241:
3236:
3231:
3225:
3223:
3217:
3216:
3214:
3213:
3208:
3203:
3198:
3193:
3188:
3183:
3178:
3173:
3168:
3163:
3158:
3153:
3148:
3143:
3138:
3133:
3128:
3126:Propylbarbital
3123:
3118:
3113:
3108:
3103:
3098:
3093:
3088:
3083:
3078:
3073:
3068:
3063:
3058:
3053:
3048:
3043:
3038:
3033:
3028:
3023:
3018:
3013:
3008:
3003:
3001:Crotylbarbital
2998:
2993:
2988:
2983:
2978:
2973:
2968:
2966:Brophebarbital
2963:
2961:Brallobarbital
2958:
2953:
2948:
2943:
2938:
2933:
2928:
2923:
2918:
2912:
2910:
2904:
2903:
2901:
2900:
2895:
2890:
2885:
2880:
2872:
2864:
2859:
2854:
2849:
2847:Methylpentynol
2844:
2839:
2834:
2829:
2824:
2819:
2809:
2804:
2799:
2794:
2788:
2786:
2780:
2779:
2773:
2766:
2765:
2758:
2751:
2743:
2734:
2733:
2730:
2729:
2728:
2727:
2724:
2713:
2707:
2701:
2700:
2697:
2696:
2693:
2692:
2690:
2689:
2684:
2679:
2670:
2662:
2645:
2639:Ademetionine (
2635:
2632:
2631:
2621:
2620:
2617:
2616:
2614:
2613:
2609:
2601:
2591:
2577:
2572:
2541:
2538:
2537:
2525:
2524:
2521:
2520:
2517:
2516:
2514:
2513:
2504:
2502:
2493:
2487:
2486:
2484:
2483:
2478:
2473:
2468:
2463:
2458:
2453:
2444:
2442:
2433:
2427:
2426:
2424:
2423:
2414:
2413:
2404:
2403:
2398:
2393:
2388:
2383:
2378:
2373:
2368:
2363:
2358:
2353:
2348:
2343:
2338:
2333:
2328:
2319:
2317:
2309:
2308:
2296:
2295:
2292:
2291:
2288:
2287:
2285:
2284:
2278:
2276:
2272:
2271:
2269:
2268:
2263:
2258:
2253:
2247:
2245:
2234:
2233:
2231:
2230:
2225:
2220:
2215:
2210:
2205:
2200:
2195:
2190:
2185:
2180:
2175:
2170:
2165:
2160:
2158:Imipraminoxide
2155:
2150:
2145:
2140:
2135:
2130:
2125:
2120:
2115:
2110:
2105:
2100:
2095:
2089:
2087:
2072:
2071:
2055:
2054:
2051:
2050:
2047:
2046:
2044:
2043:
2038:
2033:
2028:
2023:
2018:
2013:
2008:
2003:
1998:
1993:
1988:
1983:
1978:
1973:
1968:
1962:
1960:
1956:
1955:
1953:
1952:
1947:
1941:
1939:
1928:
1927:
1925:
1924:
1919:
1914:
1908:
1906:
1895:
1894:
1892:
1891:
1886:
1881:
1875:
1873:
1862:
1861:
1859:
1858:
1853:
1848:
1842:
1840:
1829:
1828:
1826:
1825:
1820:
1815:
1809:
1807:
1796:
1795:
1793:
1792:
1787:
1782:
1777:
1772:
1767:
1765:Desvenlafaxine
1761:
1759:
1748:
1747:
1745:
1744:
1739:
1734:
1729:
1724:
1719:
1714:
1709:
1703:
1701:
1686:
1685:
1668:
1667:
1655:
1654:
1647:
1640:
1632:
1626:
1625:
1613:
1599:
1598:External links
1596:
1593:
1592:
1543:
1514:(9): 951–959.
1494:
1467:(9): 676–684.
1450:
1435:
1413:
1381:
1339:
1328:
1293:
1263:
1253:
1215:
1182:
1105:
1066:
1014:
964:
950:
929:
902:
901:
899:
896:
860:
857:
822:
819:
810:
807:
771:
768:
755:
752:
742:Zuranolone is
739:
736:
722:
667:. It is taken
652:
651:
649:
648:
645:
643:
640:
632:
631:
630:
627:
626:
624:
623:
620:
612:
611:
610:
607:
606:
604:
603:
595:
593:
585:
584:
578:
572:
571:
568:
562:
556:
550:
545:
539:
538:
534:
533:
523:
515:
514:
512:
511:
503:
501:
495:
494:
492:
491:
483:
481:
475:
474:
472:
471:
463:
461:
455:
454:
452:
451:
443:
441:
435:
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432:
431:
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421:
415:
414:
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411:
403:
401:
395:
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383:
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350:
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303:
295:
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281:
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218:
214:
213:
211:
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206:
204:
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197:
192:
184:
178:
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172:
170:administration
164:
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161:
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146:
145:
143:
142:
124:
122:
116:
115:
112:
108:
107:
104:
98:
97:
44:
40:
39:
35:
34:
15:
9:
6:
4:
3:
2:
5461:
5450:
5447:
5445:
5442:
5440:
5439:Neurosteroids
5437:
5435:
5432:
5430:
5427:
5425:
5422:
5420:
5417:
5415:
5412:
5410:
5407:
5405:
5402:
5401:
5399:
5389:
5379:
5378:
5375:
5364:
5363:
5359:
5355:
5352:
5346:
5340:
5337:
5335:
5332:
5330:
5327:
5325:
5322:
5319:
5318:
5314:
5310:
5306:
5305:isovaleramide
5302:
5298:
5295:
5293:
5290:
5287:
5283:
5280:
5277:
5273:
5269:
5265:
5262:
5260:
5257:
5255:
5252:
5250:
5247:
5245:
5242:
5240:
5237:
5235:
5232:
5230:
5227:
5225:
5222:
5220:
5217:
5215:
5212:
5210:
5207:
5205:
5202:
5199:
5195:
5191:
5187:
5183:
5180:
5178:
5175:
5173:
5170:
5168:
5165:
5163:
5160:
5158:
5155:
5153:
5150:
5147:
5143:
5142:niflumic acid
5139:
5135:
5131:
5128:
5126:
5123:
5121:
5118:
5116:
5113:
5111:
5108:
5105:
5101:
5097:
5093:
5089:
5086:
5084:
5081:
5079:
5076:
5074:
5071:
5069:
5068:Clomethiazole
5066:
5064:
5063:Chlormezanone
5061:
5059:
5056:
5054:
5053:Carbamazepine
5051:
5048:
5044:
5040:
5036:
5033:
5030:
5026:
5023:
5021:
5018:
5016:
5013:
5011:
5008:
5006:
5003:
5002:
5000:
4996:
4990:
4987:
4985:
4982:
4980:
4977:
4975:
4972:
4970:
4967:
4965:
4962:
4960:
4957:
4955:
4952:
4950:
4947:
4945:
4942:
4940:
4937:
4935:
4932:
4930:
4929:Nitrous oxide
4927:
4925:
4922:
4920:
4917:
4915:
4912:
4910:
4907:
4905:
4902:
4900:
4897:
4895:
4892:
4890:
4887:
4885:
4882:
4880:
4877:
4875:
4872:
4870:
4867:
4865:
4862:
4860:
4859:Diethyl ether
4857:
4855:
4852:
4850:
4847:
4845:
4842:
4840:
4837:
4835:
4832:
4830:
4827:
4825:
4822:
4820:
4817:
4815:
4812:
4810:
4807:
4805:
4802:
4800:
4797:
4795:
4792:
4790:
4787:
4785:
4782:
4780:
4777:
4776:
4774:
4772:
4768:
4764:
4758:
4755:
4753:
4750:
4748:
4745:
4743:
4740:
4738:
4735:
4733:
4730:
4728:
4725:
4723:
4720:
4718:
4715:
4713:
4710:
4709:
4707:
4705:
4701:
4695:
4692:
4690:
4687:
4685:
4682:
4680:
4677:
4676:
4674:
4672:
4668:
4662:
4661:Pyrithyldione
4659:
4657:
4654:
4652:
4649:
4647:
4644:
4643:
4641:
4639:
4635:
4629:
4626:
4624:
4621:
4619:
4616:
4615:
4613:
4611:
4607:
4601:
4598:
4596:
4593:
4591:
4588:
4586:
4583:
4581:
4578:
4576:
4573:
4571:
4568:
4566:
4563:
4561:
4558:
4556:
4553:
4551:
4548:
4546:
4543:
4541:
4538:
4536:
4533:
4531:
4528:
4526:
4523:
4521:
4518:
4516:
4513:
4511:
4508:
4506:
4503:
4501:
4498:
4496:
4493:
4491:
4488:
4486:
4483:
4481:
4478:
4476:
4473:
4471:
4468:
4466:
4463:
4461:
4458:
4456:
4452:
4449:
4448:
4445:
4442:
4440:
4437:
4435:
4432:
4430:
4427:
4425:
4422:
4420:
4417:
4415:
4412:
4410:
4406:
4405:
4401:
4400:
4397:
4394:
4392:
4389:
4387:
4384:
4382:
4379:
4377:
4373:
4372:
4368:
4367:
4364:
4361:
4359:
4356:
4354:
4351:
4349:
4346:
4344:
4341:
4339:
4335:
4334:
4330:
4329:
4327:
4325:
4321:
4315:
4312:
4310:
4307:
4305:
4302:
4300:
4297:
4295:
4292:
4290:
4287:
4285:
4282:
4280:
4277:
4275:
4272:
4270:
4267:
4265:
4262:
4260:
4257:
4255:
4252:
4250:
4247:
4245:
4242:
4240:
4237:
4235:
4232:
4230:
4227:
4225:
4222:
4220:
4217:
4215:
4212:
4210:
4207:
4205:
4202:
4200:
4197:
4195:
4192:
4190:
4186:
4184:
4181:
4179:
4176:
4174:
4171:
4169:
4166:
4164:
4161:
4159:
4156:
4154:
4151:
4150:
4148:
4146:
4142:
4136:
4133:
4131:
4128:
4126:
4123:
4121:
4118:
4116:
4113:
4111:
4108:
4107:
4105:
4103:
4099:
4093:
4090:
4088:
4085:
4083:
4080:
4078:
4075:
4073:
4070:
4068:
4065:
4063:
4060:
4058:
4055:
4053:
4050:
4048:
4045:
4043:
4040:
4038:
4035:
4033:
4030:
4028:
4025:
4023:
4020:
4019:
4017:
4014:
4010:
4004:
4001:
3999:
3996:
3994:
3991:
3990:
3988:
3986:
3982:
3976:
3973:
3970:
3966:
3963:
3961:
3958:
3956:
3953:
3951:
3948:
3946:
3943:
3941:
3938:
3936:
3933:
3931:
3928:
3926:
3923:
3921:
3918:
3916:
3913:
3911:
3908:
3906:
3903:
3902:
3900:
3898:
3894:
3888:
3885:
3883:
3880:
3878:
3875:
3873:
3870:
3868:
3867:Phenprobamate
3865:
3863:
3860:
3858:
3855:
3853:
3850:
3848:
3845:
3843:
3840:
3838:
3835:
3833:
3832:Hexapropymate
3830:
3828:
3825:
3823:
3820:
3818:
3815:
3813:
3810:
3808:
3807:Difebarbamate
3805:
3803:
3800:
3798:
3795:
3793:
3790:
3788:
3785:
3784:
3782:
3780:
3776:
3770:
3767:
3765:
3762:
3760:
3757:
3755:
3752:
3750:
3747:
3745:
3742:
3740:
3737:
3735:
3732:
3730:
3727:
3725:
3722:
3720:
3717:
3715:
3712:
3710:
3707:
3705:
3702:
3700:
3697:
3695:
3692:
3690:
3687:
3685:
3682:
3680:
3677:
3675:
3672:
3670:
3667:
3665:
3662:
3660:
3657:
3655:
3652:
3650:
3647:
3645:
3642:
3640:
3637:
3635:
3632:
3630:
3627:
3625:
3622:
3620:
3619:Nortetrazepam
3617:
3615:
3612:
3610:
3607:
3605:
3602:
3600:
3597:
3595:
3592:
3590:
3587:
3585:
3582:
3580:
3577:
3575:
3572:
3570:
3567:
3565:
3562:
3560:
3557:
3555:
3552:
3550:
3547:
3545:
3542:
3540:
3537:
3535:
3532:
3530:
3527:
3525:
3522:
3520:
3517:
3515:
3512:
3510:
3507:
3505:
3502:
3500:
3497:
3495:
3492:
3490:
3487:
3485:
3482:
3480:
3479:Flutoprazepam
3477:
3475:
3472:
3470:
3467:
3465:
3462:
3460:
3459:Flunitrazolam
3457:
3455:
3454:Flunitrazepam
3452:
3450:
3447:
3445:
3444:Flubromazolam
3442:
3440:
3439:Flubromazepam
3437:
3435:
3432:
3430:
3427:
3425:
3422:
3420:
3417:
3415:
3412:
3410:
3407:
3405:
3402:
3400:
3397:
3395:
3392:
3390:
3387:
3385:
3382:
3380:
3377:
3375:
3372:
3370:
3367:
3365:
3362:
3360:
3357:
3355:
3352:
3350:
3347:
3345:
3342:
3340:
3339:Cloniprazepam
3337:
3335:
3332:
3330:
3327:
3325:
3322:
3320:
3317:
3315:
3312:
3310:
3307:
3305:
3302:
3300:
3297:
3295:
3292:
3290:
3287:
3285:
3282:
3280:
3277:
3275:
3272:
3270:
3267:
3265:
3262:
3260:
3257:
3255:
3252:
3250:
3247:
3245:
3242:
3240:
3237:
3235:
3232:
3230:
3229:2-Oxoquazepam
3227:
3226:
3224:
3222:
3218:
3212:
3209:
3207:
3204:
3202:
3199:
3197:
3194:
3192:
3189:
3187:
3184:
3182:
3179:
3177:
3174:
3172:
3171:Thialbarbital
3169:
3167:
3166:Tetrabarbital
3164:
3162:
3159:
3157:
3154:
3152:
3151:Spirobarbital
3149:
3147:
3144:
3142:
3139:
3137:
3134:
3132:
3131:Proxibarbital
3129:
3127:
3124:
3122:
3121:Propallylonal
3119:
3117:
3114:
3112:
3109:
3107:
3104:
3102:
3101:Phenobarbital
3099:
3097:
3094:
3092:
3091:Pentobarbital
3089:
3087:
3084:
3082:
3081:Narcobarbital
3079:
3077:
3074:
3072:
3069:
3067:
3064:
3062:
3059:
3057:
3054:
3052:
3049:
3047:
3046:Heptobarbital
3044:
3042:
3039:
3037:
3034:
3032:
3029:
3027:
3024:
3022:
3019:
3017:
3016:Difebarbamate
3014:
3012:
3009:
3007:
3006:Cyclobarbital
3004:
3002:
2999:
2997:
2994:
2992:
2989:
2987:
2984:
2982:
2979:
2977:
2974:
2972:
2969:
2967:
2964:
2962:
2959:
2957:
2954:
2952:
2951:Benzobarbital
2949:
2947:
2944:
2942:
2939:
2937:
2934:
2932:
2929:
2927:
2924:
2922:
2919:
2917:
2914:
2913:
2911:
2909:
2905:
2899:
2896:
2894:
2891:
2889:
2886:
2884:
2881:
2879:
2877:
2873:
2871:
2869:
2865:
2863:
2860:
2858:
2855:
2853:
2850:
2848:
2845:
2843:
2840:
2838:
2835:
2833:
2830:
2828:
2825:
2823:
2822:Ethchlorvynol
2820:
2817:
2813:
2810:
2808:
2805:
2803:
2800:
2798:
2795:
2793:
2790:
2789:
2787:
2785:
2781:
2777:
2764:
2759:
2757:
2752:
2750:
2745:
2744:
2741:
2725:
2723:
2720:
2719:
2717:
2714:
2711:
2708:
2706:
2703:
2702:
2698:
2688:
2685:
2683:
2680:
2678:
2671:
2669:
2667:
2663:
2660:
2656:
2652:
2651:neurosteroids
2649:
2646:
2644:
2637:
2636:
2633:
2629:Miscellaneous
2626:
2622:
2607:
2606:levothyroxine
2599:
2595:
2592:
2589:
2585:
2581:
2578:
2576:
2573:
2570:
2566:
2562:
2558:
2554:
2553:brexpiprazole
2550:
2546:
2543:
2542:
2539:
2535:
2530:
2526:
2512:
2509:
2508:Irreversible:
2506:
2505:
2503:
2497:
2488:
2482:
2479:
2477:
2474:
2472:
2469:
2467:
2464:
2462:
2459:
2457:
2454:
2452:
2449:
2446:
2445:
2443:
2437:
2428:
2422:
2419:
2416:
2415:
2412:
2409:
2406:
2405:
2402:
2399:
2397:
2394:
2392:
2389:
2387:
2384:
2382:
2379:
2377:
2374:
2372:
2369:
2367:
2364:
2362:
2359:
2357:
2354:
2352:
2349:
2347:
2344:
2342:
2341:Isocarboxazid
2339:
2337:
2334:
2332:
2329:
2327:
2324:
2323:Irreversible:
2321:
2320:
2318:
2316:Non-selective
2314:
2310:
2306:
2301:
2297:
2283:
2280:
2279:
2277:
2273:
2267:
2264:
2262:
2259:
2257:
2254:
2252:
2249:
2248:
2246:
2241:
2235:
2229:
2226:
2224:
2221:
2219:
2216:
2214:
2213:Protriptyline
2211:
2209:
2206:
2204:
2201:
2199:
2196:
2194:
2191:
2189:
2188:Nortriptyline
2186:
2184:
2183:Nitroxazepine
2181:
2179:
2176:
2174:
2171:
2169:
2166:
2164:
2161:
2159:
2156:
2154:
2151:
2149:
2146:
2144:
2141:
2139:
2136:
2134:
2131:
2129:
2126:
2124:
2123:Demexiptiline
2121:
2119:
2116:
2114:
2111:
2109:
2106:
2104:
2101:
2099:
2098:Amitriptyline
2096:
2094:
2091:
2090:
2088:
2083:
2077:
2073:
2069:
2065:
2060:
2056:
2042:
2039:
2037:
2034:
2032:
2029:
2027:
2024:
2022:
2019:
2017:
2014:
2012:
2009:
2007:
2004:
2002:
1999:
1997:
1994:
1992:
1989:
1987:
1984:
1982:
1979:
1977:
1974:
1972:
1969:
1967:
1964:
1963:
1961:
1957:
1951:
1948:
1946:
1943:
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1935:
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1920:
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1896:
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1863:
1857:
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1399:
1395:
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1305:
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1277:
1273:
1269:
1257:
1249:
1245:
1241:
1237:
1233:
1229:
1222:
1220:
1203:
1199:
1195:
1189:
1187:
1179:
1178:public domain
1160:
1158:
1152:
1146:
1144:
1142:
1140:
1138:
1136:
1134:
1132:
1130:
1128:
1126:
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1120:
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1077:
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1044:
1040:
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1032:
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1021:
1019:
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993:
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976:
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968:
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946:
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895:
893:
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876:
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866:
856:
854:
849:
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843:
838:
836:
832:
828:
818:
816:
806:
803:
802:
795:
785:
781:
777:
767:
764:
763:boxed warning
759:
751:
749:
745:
735:
733:
728:
726:
718:
714:
711:
708:
705:
704:orally active
701:
697:
693:
689:
685:
681:
677:
672:
670:
666:
662:
658:
644:
639:
638:
635:
628:
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594:
591:
586:
579:
577:
573:
546:
544:
540:
535:
531:
527:
524:
522:
520:ECHA InfoCard
516:
509:
508:ChEMBL4105630
505:
504:
502:
500:
496:
489:
485:
484:
482:
480:
476:
469:
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226:
224:
220:
215:
208:
207:
205:
203:
199:
196:
188:
185:
183:
179:
176:
173:
171:
165:
158:
157:
155:
153:
147:
140:
135:
126:
125:
123:
121:
117:
113:
109:
105:
103:
99:
95:
94:
83:
45:
43:Pronunciation
41:
38:Clinical data
36:
32:
27:
19:
5409:5β-Pregnanes
5350:
5349:
5320:
5177:Lavender oil
4919:Nitric oxide
4839:Cryofluorane
4784:Acetophenone
4742:Methaqualone
4737:Mecloqualone
4732:Mebroqualone
4722:Diproqualone
4717:Cloroqualone
4646:Glutethimide
4450:
4402:
4369:
4331:
4313:
4304:Testosterone
4269:Progesterone
4234:Hydroxydione
4183:Androsterone
4110:Acecarbromal
4015:constituents
3802:Cyclarbamate
3792:Carisoprodol
3564:Metaclazepam
3559:Menitrazepam
3549:Meclonazepam
3544:Lormetazepam
3474:Flutemazepam
3299:Ciclotizolam
3289:Carburazepam
3181:Thiobarbital
3141:Secobarbital
3106:Phetharbital
3086:Nealbarbital
3071:Methohexital
3056:Hexobarbital
2991:Butallylonal
2986:Butobarbital
2941:Barbexaclone
2936:Aprobarbital
2921:Allobarbital
2908:Barbiturates
2875:
2867:
2857:Petrichloral
2673:Oxitriptan (
2665:
2658:
2549:aripiprazole
2507:
2456:Metralindole
2447:
2417:
2407:
2386:Pivhydrazine
2376:Pheniprazine
2322:
2228:Trimipramine
2218:Quinupramine
2118:Clomipramine
2113:Butriptyline
2036:Teniloxazine
2031:Tandospirone
2016:Metryptamine
2011:Medifoxamine
1996:Indeloxazine
1950:Vortioxetine
1712:Escitalopram
1616:
1604:
1560:
1556:
1546:
1511:
1507:
1497:
1464:
1460:
1453:
1443:McKenzie H.
1438:
1426:. Retrieved
1416:
1407:10665/330879
1397:
1393:
1384:
1349:
1345:
1331:
1319:. Retrieved
1308:
1296:
1271:
1267:
1256:
1234:(2): 61–70.
1231:
1227:
1206:. Retrieved
1197:
1163:. Retrieved
1154:
1096:. Retrieved
1034:
1030:
974:
970:
944:
941:"Zuranolone"
920:. Retrieved
915:
906:
877:
862:
850:
839:
824:
821:Legal status
812:
799:
796:
773:
760:
757:
741:
738:Medical uses
729:
713:neurosteroid
676:side effects
673:
660:
656:
655:
488:CHEBI:228302
363:1632051-40-1
341:
337:
333:
329:
325:
321:
317:
313:
309:
305:
276:Elimination
223:Legal status
217:Legal status
187:Neurosteroid
120:License data
18:
5259:Stiripentol
5254:Seproxetine
5224:Niacinamide
5204:Loreclezole
5025:Avermectins
4989:Vinyl ether
4959:Sevoflurane
4939:Paraldehyde
4889:Halopropane
4712:Afloqualone
4694:Tracazolate
4689:ICI-190,622
4679:Cartazolate
4656:Piperidione
4651:Methyprylon
4618:Fospropofol
4540:Pipequaline
4348:Pazinaclone
4338:Eszopiclone
4194:Cholesterol
4178:Androstenol
4102:Monoureides
4082:Methysticin
3882:Tetrabamate
3862:Pentabamate
3852:Meprobamate
3822:Febarbamate
3787:Carisbamate
3739:Triflubazam
3729:Tolufazepam
3689:Rilmazafone
3684:Remimazolam
3659:Proflazepam
3644:Pivoxazepam
3604:Nitrazepate
3594:Nimetazepam
3529:Lopirazepam
3499:Haloxazolam
3449:Fludiazepam
3394:Doxefazepam
3369:Delorazepam
3349:Clotiazepam
3344:Clorazepate
3309:Cinolazepam
3206:Vinbarbital
3161:Tetrabamate
3116:Probarbital
3096:Phenallymal
3061:Metharbital
3036:Febarbamate
2931:Amobarbital
2832:Isopropanol
2802:Chloralodol
2712:from market
2655:brexanolone
2569:risperidone
2466:Moclobemide
2448:Reversible:
2408:Reversible:
2331:Iproclozide
2266:Setiptiline
2261:Mirtazapine
2251:Maprotiline
2208:Propizepine
2193:Noxiptiline
2178:Metapramine
2168:Lofepramine
2138:Dimetacrine
2128:Desipramine
2001:Flupentixol
1986:Etryptamine
1971:Amisulpride
1966:Agomelatine
1912:Etoperidone
1889:Setiptiline
1884:Mirtazapine
1856:Nomifensine
1813:Atomoxetine
1790:Venlafaxine
1780:Milnacipran
1722:Fluvoxamine
1618:NCT02978326
1606:NCT04442503
1266:Receptor".
1208:10 February
1198:AdisInsight
776:brexanolone
583: g·mol
526:100.271.331
288:Identifiers
283:16–23 hours
238:Schedule IV
111:Other names
102:Trade names
5398:Categories
5292:Topiramate
5282:Terpenoids
5239:Propanidid
5229:Org 25,435
5157:Flupirtine
5152:Fluoxetine
5058:Chloralose
5029:ivermectin
4934:Norflurane
4899:Isoflurane
4844:Desflurane
4834:Chloroform
4794:Aliflurane
4727:Etaqualone
4555:SB-205,384
4485:CP-615,003
4480:CL-218,872
4434:Panadiplon
4424:Lorediplon
4353:Suproclone
4314:Zuranolone
4274:Renanolone
4259:Posovolone
4239:Minaxolone
4229:Ganaxolone
4168:Alfaxalone
4163:Alfadolone
4153:Acebrochol
4120:Bromisoval
3998:Metomidate
3985:Imidazoles
3945:Hispidulin
3897:Flavonoids
3857:Nisobamate
3847:Mebutamate
3817:Ethinamate
3812:Emylcamate
3779:Carbamates
3749:Tuclazepam
3724:Tetrazepam
3679:Reclazepam
3654:Premazepam
3634:Phenazepam
3614:Nordazepam
3609:Nitrazolam
3599:Nitrazepam
3579:Motrazepam
3534:Loprazolam
3524:Lofendazam
3509:Imidazenil
3469:Flutazolam
3464:Flurazepam
3434:Fletazepam
3389:Dimdazenil
3384:Diclazepam
3364:Cyprazepam
3354:Cloxazolam
3334:Clonazolam
3329:Clonazepam
3319:Climazolam
3279:Brotizolam
3274:Bromazolam
3269:Bromazepam
3264:Bretazenil
3259:Bentazepam
3249:Arfendazam
3244:Alprazolam
3239:Adinazolam
3211:Vinylbital
3191:Thiopental
3066:Methitural
2981:Buthalital
2976:Butalbital
2827:Isobutanol
2687:Tryptophan
2659:zuranolone
2565:quetiapine
2561:olanzapine
2557:lurasidone
2511:Selegiline
2501:-selective
2481:Toloxatone
2476:Tetrindole
2471:Pirlindole
2451:Eprobemide
2441:-selective
2421:Bifemelane
2411:Caroxazone
2371:Phenelzine
2356:Mebanazine
2336:Iproniazid
2223:Tianeptine
2203:Pipofezine
2173:Melitracen
2153:Imipramine
2133:Dibenzepin
2093:Amineptine
2041:Tianeptine
2026:Pivagabine
2021:Oxaflozane
1981:Esketamine
1945:Vilazodone
1917:Nefazodone
1846:Amineptine
1823:Viloxazine
1818:Reboxetine
1770:Duloxetine
1742:Zimelidine
1737:Sertraline
1732:Paroxetine
1717:Fluoxetine
1707:Citalopram
1563:: 117277.
1352:: 108333.
1194:"SAGE 217"
977:: 108035.
967:receptors"
898:References
835:fast track
707:inhibitory
680:drowsiness
657:Zuranolone
588:3D model (
576:Molar mass
448:7ZW49N180B
419:ChemSpider
354:CAS Number
297:IUPAC name
266:Metabolism
182:Drug class
139:Zuranolone
23:Zuranolone
5449:Pyrazoles
5351:See also:
5313:valerenol
5234:Phenytoin
5214:Monastrol
5172:Lanthanum
5167:KRM-II-81
5130:Fenamates
5125:Etifoxine
5120:Etazepine
5115:Efavirenz
5073:Darigabat
4969:Teflurane
4954:Roflurane
4949:Propylene
4894:Halothane
4879:Fluroxene
4864:Enflurane
4767:Volatiles
4684:Etazolate
4595:Viqualine
4550:RWJ-51204
4515:L-838,417
4505:Imepitoin
4475:CGS-20625
4470:CGS-13767
4455:Adipiplon
4429:Ocinaplon
4391:Saripidem
4386:Necopidem
4363:Zopiclone
4358:Suriclone
4343:Pagoclone
4249:ORG-21465
4244:ORG-20599
4135:Ectylurea
4125:Carbromal
4003:Propoxate
3993:Etomidate
3920:Baicalein
3877:Styramate
3872:Procymate
3842:Lorbamate
3827:Felbamate
3797:Clocental
3769:Zomebazam
3764:Zolazepam
3759:Zapizolam
3754:Uldazepam
3734:Triazolam
3719:Temazepam
3714:Sulazepam
3704:Ro48-8684
3699:Ro48-6791
3694:Ripazepam
3664:Pyrazolam
3639:Pinazepam
3589:Nifoxipam
3574:Midazolam
3569:Mexazolam
3554:Medazepam
3539:Lorazepam
3519:Ketazolam
3514:Irazepine
3504:Iclazepam
3494:Halazepam
3489:Gidazepam
3484:Fosazepam
3404:Estazolam
3399:Elfazepam
3374:Demoxepam
3304:Cinazepam
3284:Camazepam
3254:Avizafone
3176:Thiamylal
3111:Primidone
3041:Heptabarb
3031:Eterobarb
2996:Carbubarb
2893:Triclofos
2792:Brometone
2722:Phase III
2710:Withdrawn
2575:Buspirone
2461:Minaprine
2396:Tedizolid
2391:Safrazine
2366:Octamoxin
2361:Nialamide
2351:Linezolid
2346:Isoniazid
2256:Mianserin
2198:Opipramol
2163:Iprindole
2143:Dosulepin
2108:Amoxapine
2064:Tricyclic
1922:Trazodone
1879:Mianserin
1851:Bupropion
1785:Tofenacin
1727:Indalpine
1676:Specific
1587:229333842
1489:258461851
1009:244280839
744:indicated
684:dizziness
278:half-life
168:Routes of
150:Pregnancy
5444:Nitriles
5414:Alcohols
5388:Medicine
5339:TCS-1205
5334:TCS-1105
5324:α-Pinene
5297:Valerian
5272:tetronal
5249:Safranal
5198:obovatol
5194:magnolol
5190:honokiol
5020:Alogabat
5015:AA-29504
4964:Synthane
4924:Nitrogen
4904:Kerosine
4884:Gasoline
4874:Ethylene
4814:Centalun
4809:Butylene
4623:Propofol
4585:U-89843A
4565:TGSC01AA
4535:NS-11394
4500:GBLD-345
4465:CGS-9896
4460:CGS-8216
4444:Zaleplon
4439:Taniplon
4419:Indiplon
4414:Fasiplon
4409:Divaplon
4396:Zolpidem
4299:SAGE-872
4294:SAGE-689
4289:SAGE-516
4284:SAGE-324
4279:SAGE-105
4187:Certain
4130:Capuride
4092:Yangonin
3969:baicalin
3965:Skullcap
3955:Luteolin
3930:Catechin
3925:Baicalin
3915:Apigenin
3887:Tybamate
3674:Quazepam
3669:QH-II-66
3649:Prazepam
3629:Oxazolam
3624:Oxazepam
3424:Etizolam
3379:Diazepam
3359:CP-1414S
3324:Clobazam
3314:Clazolam
3201:Valofane
3156:Talbutal
3146:Sigmodal
3051:Hexethal
2946:Barbital
2926:Alphenal
2916:(-)-DMBB
2862:Propanol
2852:Pentanol
2842:Methanol
2784:Alcohols
2648:GABAkine
2326:Benmoxin
2282:Tiazesim
2006:Ketamine
1991:Gepirone
1579:33387701
1538:34190962
1481:37132201
1428:4 August
1376:32976892
1321:5 August
1315:Archived
1288:28753313
1248:29223589
1202:Archived
1165:4 August
1098:5 August
1089:Archived
1061:33224470
1001:34793859
880:insomnia
859:Research
725:receptor
710:pregnane
688:diarrhea
678:include
669:by mouth
661:Zurzuvae
428:71117610
399:DrugBank
388:86294073
304:1-(2-((3
202:ATC code
175:By mouth
152:category
134:DailyMed
106:Zurzuvae
5434:Ketones
5286:borneol
5284:(e.g.,
5276:trional
5266:(e.g.,
5184:(e.g.,
5182:Lignans
5132:(e.g.,
5090:(e.g.,
5035:Bromide
5027:(e.g.,
5010:α-EMTBL
4974:Toluene
4944:Propane
4819:Chloral
4799:Benzene
4779:Acetone
4610:Phenols
4600:Y-23684
4590:U-90042
4575:TPA-023
4560:SX-3228
4545:ROD-188
4530:NS-2710
4525:NS-2664
4510:JM-1232
4495:ELB-139
4490:CTP-354
4376:Alpidem
3975:Wogonin
3950:Linarin
3429:FG-8205
3136:Reposal
2837:Menthol
2797:Butanol
2580:Lithium
2148:Doxepin
1680:and/or
1529:8246337
1367:8265595
1052:7656877
992:9787737
922:5 March
770:History
719:of the
692:fatigue
581:409.574
543:Formula
408:DB15490
374:PubChem
136::
93:-ə-lohn
5374:Portal
5219:Niacin
4804:Butane
4757:SL-164
4628:Thymol
4570:TP-003
4451:Others
4254:P1-185
4214:5β-DHP
4209:5α-DHP
4204:3α-DHP
4052:Kavain
3960:Rc-OMe
2705:WHO-EM
2418:Mixed:
2275:Others
1959:Others
1867:NaSSAs
1585:
1577:
1536:
1526:
1487:
1479:
1374:
1364:
1286:
1246:
1059:
1049:
1007:
999:
989:
890:, and
792:
788:
782:and a
732:Biogen
698:, and
614:SMILES
499:ChEMBL
468:D11793
270:CYP3A4
236:
132:
96:
5078:DEABL
4771:gases
4580:TP-13
4309:THDOC
4199:DHDOC
2675:5-HTP
2239:TeCAs
1900:SARIs
1834:NDRIs
1753:SNRIs
1695:SSRIs
1583:S2CID
1485:S2CID
1400:(3).
1159:(FDA)
1155:U.S.
1092:(PDF)
1085:(PDF)
1005:S2CID
873:HAM-D
702:. An
634:InChI
590:JSmol
479:ChEBI
260:99.5%
4381:DS-1
4013:Kava
3940:EGCG
2876:tert
2868:tert
2771:GABA
2641:SAMe
2081:TCAs
2066:and
1801:NRIs
1663:N06A
1575:PMID
1534:PMID
1477:PMID
1430:2023
1372:PMID
1323:2023
1284:PMID
1244:PMID
1210:2018
1167:2023
1100:2023
1057:PMID
997:PMID
924:2024
833:and
721:GABA
459:KEGG
439:UNII
250:data
209:None
191:GABA
89:zuu-
5110:DS2
4219:DHT
3935:EGC
2604:),
2492:MAO
2432:MAO
1933:SMS
1565:doi
1561:421
1524:PMC
1516:doi
1469:doi
1465:180
1402:hdl
1362:PMC
1354:doi
1350:181
1276:doi
1236:doi
1047:PMC
1039:doi
987:PMC
979:doi
975:234
378:CID
332:,17
328:,14
324:,13
320:,10
91:RAN
5400::
5360:•
5356:•
5311:,
5307:,
5303:,
5274:,
5270:,
5196:,
5192:,
5188:,
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5102:,
5098:,
5094:,
5045:,
5041:,
4453::
4407::
4374::
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2657:,
2612:))
2608:(T
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