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In the video interview, Okamoto said: "Men are always aware of the fundamental differences between men and women, and so cannot help but think of themselves as superior. So I used that to my advantage by stroking their egos. Until I could compensate for the disadvantages of being a woman by working
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However she and a coworker were asked to leave a pediatric conference, because the event was not for "women and children" (onna kodomo), a term she said in a 2012 interview she had never heard before. After she had presented her research for the first time, the male audience members ridiculed her by
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in trauma patients showed its remarkable benefit if given within 3 hours of injury. Also in 2010, the WOMAN (World
Maternal Antifibrinolytic) trial began, a randomised, double-blind, placebo-controlled study of tranexamic acid in 20 060 women with post-partum haemorrhage. Enrollment was completed in
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who had been coordinating the 2010 trauma trial visited
Okamoto, then about 92 in Japan. He said that he "found a fascinating character, really lively and vigorous and still very much engaged with research, meeting with researchers, and reading journal articles".
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in 2009. She lived to see the 2010 beginning of the study of tranexamic acid in 20 000 women with post-partum haemorrhage, but died before its completion in 2016 and the publication of tranexamic acids fatality preventing results in 2017, that she had predicted.
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with
Shosuke, who also worked at Kobe. She retired from the University in 1990. After her husband died in 2004, she led the committee until 2014. She could never persuade obstetricians to trial the drug in post-partum hemorrhage.
203:, where she worked from 1966 until her retirement in 1990. Okamoto's career was hampered by a very male dominated environment. During her lifetime she was unable to persuade obstetricians at Kobe to trial the
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Effect of early tranexamic acid administration on mortality, hysterectomy, and other morbidities in women with post-partum haemorrhage (WOMAN): an international, randomised, double-blind, placebo-controlled
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in Tokyo. As resources were scarce, she and her husband
Shosuke Okamoto changed to research on blood: "If there was not enough we could simply use our own". They hoped to find a treatment for
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2016, and in April 2017, the results were published and showed that tranexamic acid reduced death in the 10,036 treated women versus the 9985 on placebo with no adverse effects.
520:"Protocol 09PRT/4179:Tranexamic acid for the treatment of postpartum haemorrhage: an international, randomised, double blind, placebo controlled trial (the WOMAN Trial)"
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for her daughter and brought her to the laboratory, " that she would behave herself". She carried her on her back as an infant while working in the lab.
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under a neurophysiologist who "created many more opportunities for than were otherwise available at the time." After World War II and the
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469:"PROPOSAL FOR THE INCLUSION OF TRANEXAMIC ACID (ANTI-FIBRINOLYTIC – LYSINE ANALOGUE) IN THE WHO MODEL LIST OF ESSENTIAL MEDICINES"
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Utako
Okamoto was married to Shosuke Okamoto and at her death was survived by one daughter, Kumi Nakamura. She had one
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260:(EACA). They then studied a related chemical, 1-(aminomethyl)-cyclohexane-4-carboxylic acid (AMCHA), also known as
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Tranexamic acid's value remained unappreciated for years, and it was not until 2009, that it was included on the
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longer hours—10 hours per day instead of the 8 that the men worked." At Keio
University, she could not find
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Okamoto began studying dentistry in 1936. She very soon switched to medicine enrolling at the
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in the 1950s in her quest to find a drug that would treat bleeding after childbirth (
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585:. London School of Hygiene & Tropical Medicine. 8 March 2012. Archived from
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agent and published their findings in the Keio
Journal of Medicine in 1962.
614:, 15 min video, YouTube, TheLancetTV, 13 December 2013, accessed 3 June 2016
583:"Utako Okamoto: The challenges of balancing laboratory work with motherhood"
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256:, a potent drug to stop bleeding after childbirth. They began by studying
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264:. The Okamotos found it was 27 times as powerful and thus a promising
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199:). After publishing results in 1962 she became a chair at
446:"Bringing women to the forefront of science and medicine"
494:"Drug will save lives of accident victims, says study"
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In male dominated Japan, Okamoto had to fight against
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Committee for
Projects on Thrombosis and Haemostasis
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at Tokyo Women's
Medical University researching the
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Shosuke
Okamoto (husband), Kumi Nakamura (daughter)
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338:London School of Hygiene & Tropical Medicine
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316:asking if she was going to dance for them.
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232:In January 1942, Okamoto started out as a
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82:Tokyo Women's Medical University (MD)
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549:The Lancet, April 26, 2017. pp1-12.
292:to be used during cardiac surgery.
244:respectively in 1945, she moved to
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467:Paul Carless (25 November 2008).
673:21st-century Japanese physicians
663:20th-century Japanese physicians
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224:and graduated in December 1941.
222:Tokyo Women's Medical University
290:WHO list of essential medicines
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275:. In 1980, she founded a local
209:WHO list of essential medicines
185:, 1 April 1918 – 21 April 2016)
568:Life and work of Okamoto Utako
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418:10.1016/S0140-6736(16)30697-3
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633:Japanese medical researchers
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448:. The Lancet. 10 March 2012
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297:randomised controlled trial
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544:WOMAN Trial Collaborators
258:epsilon-amino-caproic acid
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643:Japanese women academics
401:"Obituary Utako Okamoto"
242:Second Sino-Japanese War
658:Discrimination in Japan
526:. Elsevier Limited. n.d
254:post-partum haemorrhage
197:post-partum haemorrhage
16:Japanese medical doctor
273:Kobe Gakuin University
201:Kobe Gakuin University
137:Kobe Gakuin University
648:Physicians from Tokyo
612:CRASH-2 Utako Okamoto
399:Geoff Watts (2016).
351:Obstetrical bleeding
361:Sexism in academia
234:research assistant
474:. WHO. p. 35
295:In 2010, a large
189:medical scientist
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95:Years active
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246:Keio University
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193:tranexamic acid
191:who discovered
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143:Sub-specialties
133:Keio University
108:tranexamic acid
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591:. Retrieved
587:the original
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284:Achievements
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250:Shinanomachi
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129:Institutions
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60:(2016-04-21)
49:Tokyo, Japan
46:1 April 1918
18:
638:1918 births
628:2016 deaths
334:miscarriage
147:antiplasmin
106:discovered
71:Nationality
65:Kobe, Japan
622:Categories
524:The Lancet
405:The Lancet
367:References
266:hemostatic
238:cerebellum
158:hemostasis
87:Occupation
304:Obstacles
216:Education
114:Relatives
98:1945–2014
79:Education
498:BBC News
427:27308678
345:See also
322:day care
156:blood /
153:Research
74:Japanese
593:3 June
530:3 June
504:3 June
500:. 2010
478:3 June
452:3 June
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310:sexism
228:Career
547:trial
472:(PDF)
595:2016
532:2016
506:2016
480:2016
454:2016
423:PMID
176:岡本歌子
55:Died
43:Born
413:doi
409:387
248:in
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Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
