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gene is the most common gene mutation found in cancer cells. A study has shown that p53 mutations are common in tobacco-related cancers, with a variation in the amount of G-T transversions in lung cancer from smokers and non-smokers. In smokers’ lung cancer, the prevalence of G-T transversions is 30%
179:
Of the natural nitrogenous bases of DNA, guanine is most prone to oxidation. Oxidation of guanine, also known as oxidative guanine damage, results in the formation of many products. These products trigger mutations, leading to DNA damage, and can pair with adenine and guanine through hydrogen bonding
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The location of a transversion mutation on a gene coding for a protein correlates with the extent of the mutation. If the mutation occurs at a site that is not involved with the shape of a protein or the structure of an enzyme or its active site, the mutation will not have a significant effect on the
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per base, transition mutations are more likely than transversions because substituting a single ring structure for another single ring structure is more likely than substituting a double ring for a single ring. Also, transitions are less likely to result in amino acid substitutions (due to
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cell or the enzymatic activity of its proteins. If the mutation occurs at a site that changes the structure or function of a protein, therefore changing its enzymatic activity, the mutation can have significant effects on the survival of the cell.
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compared to that of 12% in non-smokers. At many p53 mutational hotspots, a large number of the mutations are G-T events in lung cancers but almost exclusively G-A transitions in non-tobacco-related cancers.
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Illustration of a transversion: each of the 8 nucleotide changes between a purine and a pyrimidine (in red). The 4 other changes are
437:
Pfeifer, Gerd P.; Denissenko, Mikhail F.; Olivier, Magali; Tretyakova, Natalia; Hecht, Stephen S.; Hainaut, Pierre (2002-10-15).
154:(8-oxoG) causes spontaneous and heritable G to T transversion mutations. These mutations occur in different stages of the
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103:(SNPs). A transversion usually has a more pronounced effect than a transition because the second and third nucleotide
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Ohno M, Sakumi K, Fukumura R, Furuichi M, Iwasaki Y, Hokama M, Ikemura T, Tsuzuki T, Gondo Y, Nakabeppu Y (2014).
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Kino, Katsuhito; Kawada, Taishu; Hirao-Suzuki, Masayo; Morikawa, Masayuki; Miyazawa, Hiroshi (2020-10-15).
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DNA point mutation that exchanges a purine (A or G) for a pyrimidine (C or T) or vice versa
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119:, is more tolerant of transition than a transversion: transitions are more likely to be
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439:"Tobacco smoke carcinogens, DNA damage and p53 mutations in smoking-associated cancers"
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286:"8-oxoguanine causes spontaneous de novo germline mutations in mice"
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Although there are two possible transversions but only one possible
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380:"Products of Oxidative Guanine Damage Form Base Pairs with Guanine"
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causing G-T transversions and G-C transversions, respectively.
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Transversion and p53 mutations in smoking-associated cancers
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Transversions due to products of oxidative guanine damage
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150:in the germ line of mice, the oxidized base
384:International Journal of Molecular Sciences
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158:lineage and are distributed throughout the
123:than transversions, as one observes in the
78:. It can only be reversed by a spontaneous
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493:"Transition versus Transversion mutations"
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665:Mutation with respect to overall fitness
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138:(8-oxodG) is an oxidized derivative of
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495:. Memorial University of Newfoundland.
166:Consequences of transversion mutations
142:, and is one of the major products of
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86:Ratio of transitions to transversions
500:Nikolay's Genetics Lessons (2014).
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590:Mutation with respect to structure
355:10.1016/B978-0-12-386454-3.00392-4
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131:Spontaneous germline transversion
510:from the original on 2021-12-22.
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101:single nucleotide polymorphisms
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58:) is changed for a (one ring)
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341:Landolph, J.R. (2014-01-01).
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46:in which a single (two ring)
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647:Chromosomal translocations
347:Encyclopedia of Toxicology
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252:(3rd ed.). Sinauer.
121:synonymous substitutions
687:Nearly neutral mutation
136:8-oxo-2'-deoxyguanosine
697:Nonsynonymous mutation
652:Chromosomal inversions
554:Mechanisms of mutation
456:10.1038/sj.onc.1205803
248:Futuyma, D.J. (2013).
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677:Advantageous mutation
616:Conservative mutation
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672:Deleterious mutation
640:Large-scale mutation
397:10.3390/ijms21207645
349:. pp. 715–725.
343:"Genetic Toxicology"
188:The mutation of the
692:Synonymous mutation
626:Frameshift mutation
302:2014NatSR...4E4689O
72:ionizing radiation
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611:Missense mutation
606:Nonsense mutation
449:(48): 7435–7451.
310:10.1038/srep04689
273:Diagram at mun.ca
208:Aristolochic acid
76:alkylating agents
36:molecular biology
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682:Neutral mutation
631:Dynamic mutation
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40:point mutation
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152:8-oxoguanine
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32:Transversion
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506:. Youtube.
160:chromosomes
125:codon table
25:transitions
579:Transition
235:References
203:Transition
113:degeneracy
92:transition
60:pyrimidine
27:(in blue).
561:Insertion
465:1476-5594
406:1422-0067
250:Evolution
156:germ cell
146:. During
80:reversion
718:Mutation
712:Category
566:Deletion
547:Mutation
508:Archived
473:12379884
443:Oncogene
424:33076559
328:24732879
296:: 4689.
197:See also
415:7589758
319:3986730
298:Bibcode
290:Sci Rep
219:Guanine
115:of the
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48:purine
105:codon
34:, in
469:PMID
461:ISSN
420:PMID
402:ISSN
359:ISBN
324:PMID
254:ISBN
117:code
451:doi
410:PMC
392:doi
351:doi
314:PMC
306:doi
214:P53
190:P53
109:DNA
74:or
66:or
54:or
44:DNA
42:in
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68:C
64:T
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56:G
52:A
50:(
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
