37:
353:, exhibits potent proapoptotic activity in cultured cells, while clinically it is very well tolerated with therapeutic benefits reported against several malignancies. In 2005, ABT-510 was evaluated in phase II clinical trials for the treatment of several types of cancer.
788:
Haviv F, Bradley MF, Kalvin DM, et al. (April 2005). "Thrombospondin-1 mimetic peptide inhibitors of angiogenesis and tumor growth: design, synthesis, and optimization of pharmacokinetics and biological activities".
334:
of the cell. Since tumors overexpressing TSP-1 typically grow slower, exhibit less angiogenesis, and have fewer metastases, TSP1 is an attractive target for cancer treatment. Because
310:, inhibiting the proliferation and migration of endothelial cells by interactions with CD36 expressed on their surface of these cells. Inhibitory peptides and fragments of
345:
monomer), not very abundant and exerts multiple actions, its clinical usefulness is questionable. However, small-molecules based on a CD36-binding peptide sequence from
160:
227:
The thrombospondins are a family of multifunctional proteins. The family consists of thrombospondins 1-5 and can be divided into 2 subgroups: A, which contains
497:
453:
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that had been stimulated with thrombin, and so was designated 'thrombin-sensitive protein'. Since its first recognition, functions for
493:
247:
or COMP). TSP-1 and TSP-2 are homotrimers, consisting of three identical subunits, whereas TSP-3, TSP-4 and TSP-5 are homopentamers.
84:
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Christopherson KS; Ullian EM; Stokes CC; Mullowney CE; Hell JW; Agah A; Lawler J; Mosher DF; Bornstein P; Barres BA. (2005).
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have been found in multiple biological processes including angiogenesis, apoptosis, activation of
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741:"Thrombospondins are astrocyte-secreted proteins that promote CNS synaptogenesis"
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and Immune regulation. As such, TSP-1 is designated a multifunctional protein.
204:
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Sorbera LA, Bayes M (2005). "ABT-510: oncolytic angiogenesis inhibitor".
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during brain development, which promotes the development of new
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322:(FasL), which activates its specific, ubiquitous receptor,
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682:"A Thrombin-Sensitive Protein of Human Platelet Membranes"
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219:(THBS1), was discovered in 1971 by Nancy L. Baenziger.
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Morris, Aaron H.; Kyriakides, Themis R. (July 2014).
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Baenziger NL, Brodie GN, Majerus PW (January 1971).
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207:functions. Due to their dynamic role within the
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291:TSP-1 has multiple receptors, among which
856:at the U.S. National Library of Medicine
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715:
705:
653:
630:"Matricellular proteins and biomaterials"
250:TSP-1 and TSP-2 are produced by immature
272:Thrombospondin 1 (TSP-1) is encoded by
14:
898:
357:Human proteins containing this domain
261:
24:
326:. This leads to the activation of
215:. The first member of the family,
25:
922:
847:
35:
318:, leading to the expression of
838:10.1358/dof.2005.030.11.949588
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791:Journal of Medicinal Chemistry
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732:
621:
349:are being tested. One analog,
276:. It was first isolated from
13:
1:
832:(11). Prous Science: 1081–6.
615:
132:Available protein structures:
686:Proc. Natl. Acad. Sci. U.S.A
646:10.1016/j.matbio.2014.03.002
245:cartilage oligomeric protein
30:Thrombospondin type 1 domain
7:
338:is extremely large (~
243:and TSP-5 (also designated
199:) are a family of secreted
10:
927:
758:10.1016/j.cell.2004.12.020
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174:
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136:
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858:Medical Subject Headings
303:are of particular note.
235:, and B, which contains
222:
892:(also known as "THBS5")
213:matricellular proteins
707:10.1073/pnas.68.1.240
211:they are considered
209:extracellular matrix
826:Drugs of the Future
698:1971PNAS...68..240B
803:10.1021/jm0401560
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189:
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181:structure summary
16:(Redirected from
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268:Thrombospondin 1
262:Thrombospondin 1
217:thrombospondin 1
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41:Thrombospondin-1
39:
27:
26:
21:
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911:Protein domains
906:Thrombospondins
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854:Thrombospondins
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193:Thrombospondins
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18:Thrombospondins
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5:
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848:External links
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797:(8): 2838–46.
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634:Matrix Biology
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308:antiangiogenic
266:Main article:
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205:antiangiogenic
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640:: 183–191.
47:Identifiers
900:Categories
616:References
320:FAS ligand
252:astrocytes
144:structures
476:;
472:;
340:120
332:apoptosis
306:TSP-1 is
301:integrins
278:platelets
78:IPR000884
811:15828822
767:15707899
664:24657843
528:;
500:;
484:;
480:;
454:ADAMTSL5
450:ADAMTSL4
446:ADAMTSL3
442:ADAMTSL2
438:ADAMTSL1
406:ADAMTS20
398:ADAMTS19
394:ADAMTS18
390:ADAMTS17
386:ADAMTS16
382:ADAMTS15
378:ADAMTS14
374:ADAMTS13
370:ADAMTS12
366:ADAMTS10
328:caspases
314:bind to
286:TGF-beta
256:synapses
161:RCSB PDB
73:InterPro
775:5772111
726:5276296
694:Bibcode
655:4167162
560:;
524:;
512:;
504:;
494:C9orf94
468:;
464:;
460:;
434:ADAMTS9
430:ADAMTS8
426:ADAMTS7
422:ADAMTS6
418:ADAMTS5
414:ADAMTS4
410:ADAMTS3
402:ADAMTS2
362:ADAMTS1
351:ABT-510
102:PS50092
97:PROSITE
90:SM00209
66:PF00090
860:(MeSH)
809:
773:
765:
724:
717:391203
714:
662:
652:
608:;
604:;
600:;
596:;
592:;
588:;
582:THSD7B
578:THSD7A
576:;
572:;
568:;
564:;
556:;
546:SEMA5B
542:SEMA5A
540:;
536:;
532:;
516:;
508:;
490:C9orf8
176:PDBsum
150:
140:
122:SUPFAM
52:Symbol
883:THBS4
877:THBS3
871:THBS2
865:THBS1
771:S2CID
610:WISP3
606:WISP2
602:WISP1
598:UNC5D
594:UNC5C
590:UNC5B
586:UNC5A
580:;
574:THSD3
570:THSD1
566:THBS2
562:THBS1
554:SPON2
550:SPON1
548:;
544:;
538:RSPO3
534:RSPO1
530:PAPLN
518:HMCN1
514:CYR61
506:CILP2
492:;
282:TSP-1
274:THBS1
241:TSP-4
237:TSP-3
233:TSP-2
229:TSP-1
223:Types
203:with
118:SCOPe
109:SCOP2
85:SMART
55:TSP_1
889:COMP
807:PMID
763:PMID
745:Cell
722:PMID
660:PMID
558:SSPO
522:LIBC
510:CTGF
502:CILP
496:;
466:BAI3
462:BAI2
458:BAI1
436:;
432:;
428:;
420:;
416:;
412:;
404:;
364:;
347:TSP1
336:TSP1
330:and
316:CD36
312:TSP1
299:and
297:CD47
293:CD36
231:and
197:TSPs
169:PDBj
165:PDBe
148:ECOD
138:Pfam
114:1lsl
61:Pfam
834:doi
799:doi
753:doi
749:120
712:PMC
702:doi
650:PMC
642:doi
526:NOV
498:CFP
482:C8B
478:C8A
452:;
448:;
444:;
440:;
408:;
400:;
396:;
388:;
384:;
380:;
376:;
372:;
368:;
342:kDa
324:Fas
156:PDB
902::
886:,
880:,
874:,
868:,
830:30
828:.
805:.
795:48
793:.
769:.
761:.
747:.
743:.
720:.
710:.
700:.
690:68
688:.
684:.
672:^
658:.
648:.
638:37
636:.
632:.
612:;
584:;
552:;
520:;
488:;
486:C9
474:C7
470:C6
456:;
424:;
392:;
295:,
258:.
239:,
167:;
163:;
146:/
120:/
116:/
840:.
836::
813:.
801::
777:.
755::
728:.
704::
696::
666:.
644::
195:(
20:)
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