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builds on the domain descriptions of PROSITE. It provides additional information about functionally or structurally critical amino acids. The rules contain information about biologically meaningful residues, like active sites,
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can be propagated to biologically related organisms, and for different or poorly known genes biochemical functions can be predicted from similarities. PROSITE offers tools for protein
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PROSITE's uses include identifying possible functions of newly discovered proteins and analysis of known proteins for previously undetermined activity. Properties from well-studied
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236:— a centralized database, grouping data from databases of protein families, domains and functional sites - part of the data come from PROSITE.
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As of 26 February 2022, release 2022_01 has 1,902 documentation entries, 1,311 patterns, 1,336 profiles, and 1,352 ProRules.
262:"ScanProsite: detection of PROSITE signature matches and ProRule-associated functional and structural residues in proteins"
156:, who directed the group for more than 20 years. Since July 2018, the director of PROSITE and Swiss-Prot is Alan Bridge.
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Hulo N, Bairoch A, Bulliard V, Cerutti L, Cuche B, De Castro E, Lachaize C, Langendijk-Genevaux PS, Sigrist CJA (2007).
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De Castro E, Sigrist CJA, Gattiker A, Bulliard V, Langendijk-Genevaux PS, Gasteiger E, Bairoch A, Hulo N (2006).
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bonds, to help function determination. These can automatically generate annotation based on PROSITE motifs.
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360:"ProRule: a new database containing functional and structural information on PROSITE profiles"
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Sigrist CJ, De Castro E, Langendijk-Genevaux PS, Le Saux V, Bairoch A, Hulo N (2005).
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PROSITE, a protein domain database for functional characterization and annotation.
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patterns and profiles in them. These are manually curated by a team of the
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Database of protein domains, families and functional sites
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152:protein annotation. PROSITE was created in 1988 by
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65:Structural Biology and Bioinformatics Department
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240:Protein subcellular localization prediction
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128:. It consists of entries describing the
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242:— another example of use of PROSITE.
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146:Swiss Institute of Bioinformatics
57:Swiss Institute of Bioinformatics
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272:(Web Server issue): W362–365.
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376:10.1093/bioinformatics/bti614
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148:and tightly integrated into
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321:(Database issue): D245–9.
311:"The 20 years of PROSITE"
167:and motif detection (see
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202:modification sites or
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426:Biological databases
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327:10.1093/nar/gkm977
278:10.1093/nar/gkl124
182:analysis servers.
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370:(21): 4060–4066.
315:Nucleic Acids Res
266:Nucleic Acids Res
200:posttranslational
165:sequence analysis
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403:Official website
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228:protein database
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198:-binding sites,
173:PROSITE patterns
138:functional sites
130:protein families
126:protein database
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70:Primary citation
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154:Amos Bairoch
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84:Release date
140:as well as
39:Description
431:Proteomics
420:Categories
247:References
210:Statistics
180:proteomics
150:Swiss-Prot
142:amino acid
62:Laboratory
204:disulfide
196:co-factor
192:substrate
384:16091411
345:18003654
296:16845026
234:InterPro
218:See also
78:19858104
410:ProRule
336:2238851
287:1538847
224:Uniprot
187:ProRule
134:domains
122:PROSITE
111:.expasy
109:prosite
104:Website
89: (
47:Contact
34:Content
20:PROSITE
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177:ExPASy
99:Access
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194:- or
161:genes
124:is a
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341:PMID
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136:and
113:.org
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372:doi
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Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
