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Thermoreceptor

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238:(TRP) family of proteins. The transduction of temperature in cold receptors is mediated in part by the TRPM8 channel. This channel passes a mixed inward cationic (predominantly carried by Na ions although the channel is also permeable to Ca) current of a magnitude that is inversely proportional to temperature. The channel is sensitive over a temperature range spanning about 10-35 Â°C. TRPM8 can also be activated by the binding of an extracellular ligand. Menthol can activate the TRPM8 channel in this way. Since the TRPM8 is expressed in neurons whose physiological role is to signal cooling, menthol applied to various bodily surfaces evokes a sensation of cooling. The feeling of freshness associated with the activation of cold receptors by menthol, particularly those in facial areas with axons in the 61:(faster conduction velocity). The adequate stimulus for a warm receptor is warming, which results in an increase in their action potential discharge rate. Cooling results in a decrease in warm receptor discharge rate. For cold receptors their firing rate increases during cooling and decreases during warming. Some cold receptors also respond with a brief action potential discharge to high temperatures, i.e. typically above 45 Â°C, and this is known as a paradoxical response to heat. The mechanism responsible for this behavior has not been determined. 20: 141: 188:, an active chemical commonly found in chili peppers. When coming in contact with your tongue (or any internal surface), the capsaicin de-polarizes the nerve fibers, allowing sodium and calcium into the fibers. In order for fibers to do so, they must have a specific thermoreceptor. The thermoreceptor reacting to capsaicin and other heat producing chemicals is known as 200:
or other cooling agents. Studies performed on mice determined that the presence of both these receptors allows for a gradient of temperature sensing. Mice lacking the TRPV1 receptor were still capable of determining areas significantly colder than on a heated platform. Mice lacking the TRPM8 receptor
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cold receptors are thought to respond with an increase in firing rate to cooling produced by evaporation of lacrimal fluid 'tears' and thereby to elicit a blink reflex. Other thermoreceptors will react to opposite triggers and give rise to heat and in some cases even burning sensations. This is often
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It has been suggested that it is the constellation of various thermally sensitive proteins together in a neuron that gives rise to a cold receptor. This emergent property of the neuron is thought to comprise, the expression of the aforementioned proteins as well as various voltage-sensitive channels
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that may respond to noxious cold, noxious heat or more than one noxious stimulus modality (i.e., they are polymodal). The nerve endings of sensory neurons that respond preferentially to cooling are found in moderate density in the skin but also occur in relatively high spatial density in the
112:. Neurons from the pre-optic and hypothalamic regions of the brain that respond to small changes in temperature have also been described, providing information on core temperature. The hypothalamus is involved in 196:. Unlike TRPV1, TRPM8 produces cooling sensations as mentioned previously. Similar to TRPV1, TRPM8 responds to a certain chemical trigger by opening its ion pathways. In this case, the chemical trigger is often 245:
Another molecular component of cold transduction is the temperature dependence of so-called leak channels which pass an outward current carried by potassium ions. Some leak channels derive from the family of
226:, and facial skin. The speculation is that lingual cold receptors deliver information that modulates the sense of taste; i.e. some foods taste good when cold, while others do not. 192:. In response to heat, the TRPV1 receptor opens up passages that allow ions to pass through, causing the sensation of heat or burning. TRPV1 also has a molecular cousin, 201:
however, were not able to determine the difference between a warm platform and a cold platform, suggesting we rely on TRPM8 to determine cold feelings and sensations.
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that extrudes 3Na ions in exchange for 2K ions for each hydrolytic cleavage of ATP. This results in a net movement of positive charge out of the cell, i.e. a
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Warm and cold receptors play a part in sensing innocuous environmental temperature. Temperatures likely to damage an organism are sensed by sub-categories of
561: 250:. Amongst the various members of the 2P-domain channels, some close quite promptly at temperatures less than about 28 Â°C (e.g. 467: 271: 554: 385: 351: 1608: 73:
temperature or pressure sensations enter the spinal cord. The Lissauer's tract will synapse on first-order neurons in
547: 247: 1026: 242:, accounts for its use in numerous toiletries including toothpaste, shaving lotions, facial creams and the like. 1041: 90: 234:
This area of research has recently received considerable attention with the identification and cloning of the
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responses to a predicted change in core body temperature in response to changing environmental conditions.
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Cold-sensitive thermoreceptors give rise to the sensations of cooling, cold and freshness. In the
1431: 807: 132:. The mechanism of activation in response to temperature changes is not completely understood. 1595: 1426: 1036: 822: 641: 495:"Specificity of cold thermotransduction is determined by differential ionic channel expression" 117: 1633: 623: 603: 340:"Chapter 38 - Single-Unit Recordings of Afferent Human Peripheral Nerves by Microneurography" 298:"Warm fibers innervating palmar and digital skin of the monkey: responses to thermal stimuli" 1494: 1461: 1160: 875: 779: 8: 1150: 1135: 1021: 960: 896: 500: 419: 86: 70: 1234: 1186: 1140: 1079: 1064: 618: 525: 444: 431: 407: 101: 35: 1690: 1659: 1436: 1383: 1314: 1155: 1145: 901: 891: 860: 764: 666: 582: 517: 449: 381: 347: 338:
Torebjörk, ERIK; Schmelz, MARTIN (2005-01-01), Dyck, Peter J.; Thomas, P. K. (eds.),
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Eliav, Eli; Gracely, Richard H (2008-01-01), Sharav, Yair; Benoliel, Rafael (eds.),
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In mammals, temperature receptors innervate various tissues including the skin (as
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Darian-Smith I, Johnson KO, LaMotte C, Shigenaga Y, Kenins P, Champness P (1979).
1393: 1334: 1306: 1122: 1097: 1092: 1087: 1046: 855: 812: 759: 255: 109: 19: 1711: 1562: 1514: 1229: 955: 906: 842: 790: 746: 608: 81:, one or two vertebral levels up. The axons of these second-order neurons then 39: 316: 266:. The magnitude of this current is proportional to the rate of pump activity. 1781: 1731: 1726: 1680: 1618: 1603: 1499: 1221: 1165: 980: 947: 931: 850: 794: 754: 703: 694: 651: 435: 58: 1685: 1664: 1649: 1623: 1441: 1262: 1239: 1211: 1206: 1130: 1069: 832: 817: 539: 521: 453: 274:
and the rapidly activating and inactivating transient potassium channel (IK
1746: 1654: 1628: 1613: 1575: 1398: 1373: 1368: 1358: 1344: 970: 926: 802: 731: 324: 259: 82: 74: 43: 494: 1766: 1721: 1585: 1580: 1552: 1532: 1456: 1416: 1363: 1348: 1272: 736: 726: 633: 574: 210: 1378: 1324: 1191: 721: 711: 656: 646: 185: 140: 1547: 1537: 1527: 1466: 1339: 1196: 994: 294: 94: 54: 513: 1716: 1570: 1522: 1484: 1388: 1329: 661: 468:"Why Does Food Taste Different When It's Cold Vs. When It's Hot?" 223: 197: 975: 965: 671: 254:(TRAAK), TREK). Temperature also modulates the activity of the 219: 215: 180: 105: 51: 1201: 1003: 916: 911: 685: 595: 570: 251: 193: 189: 173: 165: 161: 157: 153: 149: 145: 32: 1736: 1489: 169: 128:
Thermoreceptors have been classically described as having
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Thermoreceptors of the skin sense the temperature of water
716: 46:, primarily within the innocuous range. In the mammalian 491: 408:"Molecular sensors and modulators of thermoreception" 346:, Philadelphia: W.B. Saunders, pp. 1003–1014, 493: 296: 1779: 337: 38:, or more accurately the receptive portion of a 42:, that codes absolute and relative changes in 555: 569: 371: 229: 270:including the hyperpolarization-activated, 562: 548: 492:Viana F, de la Peña E, Belmonte C (2002). 374:"Chapter 3 - Measuring and assessing pain" 443: 184:experienced when coming in contact with 139: 18: 248:two-pore (2P) domain potassium channels 1780: 344:Peripheral Neuropathy (Fourth Edition) 780:Somatosensory system (sense of touch) 543: 405: 272:cyclic nucleotide-gated (HCN) channel 50:, warmth receptors are thought to be 16:Receptive portion of a sensory neuron 765:Vestibular system (sense of balance) 380:, Edinburgh: Mosby, pp. 45–56, 13: 760:Auditory system (sense of hearing) 14: 1799: 775:Gustatory system (sense of taste) 770:Olfactory system (sense of smell) 89:as they ascend to neurons in the 1027:Infrared sensing in vampire bats 755:Visual system (sense of vision) 204: 116:, the thermoreceptors allowing 485: 460: 399: 365: 331: 288: 130:free –non-specialized– endings 91:ventral posterolateral nucleus 69:In humans, along the axons of 1: 897:Auditory perception (hearing) 428:10.1080/19336950.2015.1025186 281: 1543:Olfactory reference syndrome 1320:Alice in Wonderland syndrome 236:Transient Receptor Potential 123: 7: 1742:Sensory processing disorder 912:Gustation (taste or flavor) 902:Equilibrioception (balance) 378:Orofacial Pain and Headache 135: 64: 10: 1806: 1696:Supernumerary phantom limb 1032:Infrared sensing in snakes 892:Visual perception (vision) 304:Journal of Neurophysiology 1759: 1704: 1673: 1642: 1594: 1561: 1513: 1475: 1447:Microwave auditory effect 1407: 1305: 1298: 1271: 1248: 1220: 1179: 1121: 1110: 1078: 1055: 1002: 993: 946: 884: 841: 788: 745: 702: 693: 684: 632: 614:Transduction (physiology) 594: 581: 317:10.1152/jn.1979.42.5.1297 230:Mechanism of transduction 48:peripheral nervous system 1452:Music-specific disorders 808:Vestibulocochlear (VIII) 1432:Auditory verbal agnosia 1286:Juxtacapillary receptor 264:hyperpolarizing current 258:. The Na/K-ATPase is a 1427:Auditory hallucination 1037:Surface wave detection 642:Multimodal integration 406:Zhang, Xuming (2015). 176: 24: 1686:Phantom limb syndrome 1634:Tactile hallucination 823:Glossopharyngeal (IX) 624:Active sensory system 143: 31:is a non-specialised 22: 1495:Labyrinthine fistula 1462:Spatial hearing loss 1161:Campaniform sensilla 876:Somatosensory cortex 420:Taylor & Francis 240:trigeminal (V) nerve 1281:Nociceptin receptor 1151:Merkel nerve ending 1136:Mechanotransduction 501:Nature Neuroscience 102:cutaneous receptors 87:spinothalamic tract 1643:Nociception (pain) 1235:Olfactory receptor 1187:Photoreceptor cell 1141:Lamellar corpuscle 1065:Photomorphogenesis 927:nociception (pain) 619:Sensory processing 177: 25: 1788:Sensory receptors 1775: 1774: 1760:Biases and errors 1755: 1754: 1691:Somatoparaphrenia 1660:Pain dissociation 1505:MĂ©nière's disease 1437:Cortical deafness 1315:Visual impairment 1294: 1293: 1156:Bulbous corpuscle 1146:Tactile corpuscle 1114:sensory receptors 1106: 1105: 989: 988: 942: 941: 907:Olfaction (smell) 861:Vestibular cortex 843:Cerebral cortices 680: 679: 667:Motion perception 387:978-0-7234-3412-2 353:978-0-7216-9491-7 1795: 1422:Auditory agnosia 1354:Optic neuropathy 1303: 1302: 1171:Stretch receptor 1119: 1118: 1017:Magnetoreception 1012:Electroreception 1000: 999: 922:mechanoreception 871:Gustatory cortex 866:Olfactory cortex 700: 699: 691: 690: 609:Sensory receptor 592: 591: 564: 557: 550: 541: 540: 534: 533: 497: 489: 483: 482: 480: 479: 464: 458: 457: 447: 403: 397: 396: 395: 394: 369: 363: 362: 361: 360: 335: 329: 328: 311:(5): 1297–1315. 300: 292: 144:Channels shown: 114:thermoregulation 71:Lissauer's tract 1805: 1804: 1798: 1797: 1796: 1794: 1793: 1792: 1778: 1777: 1776: 1771: 1751: 1700: 1669: 1638: 1590: 1557: 1509: 1471: 1403: 1394:Stereoblindness 1335:Color blindness 1290: 1267: 1244: 1216: 1175: 1123:Mechanoreceptor 1112: 1102: 1098:Machine hearing 1093:Computer vision 1088:Robotic sensing 1074: 1051: 985: 938: 880: 856:Auditory cortex 837: 784: 747:Sensory systems 741: 676: 628: 586: 584: 577: 568: 538: 537: 490: 486: 477: 475: 466: 465: 461: 404: 400: 392: 390: 388: 370: 366: 358: 356: 354: 336: 332: 293: 289: 284: 277: 232: 207: 138: 126: 110:urinary bladder 67: 17: 12: 11: 5: 1803: 1802: 1791: 1790: 1773: 1772: 1770: 1769: 1763: 1761: 1757: 1756: 1753: 1752: 1750: 1749: 1744: 1739: 1734: 1729: 1724: 1719: 1714: 1708: 1706: 1702: 1701: 1699: 1698: 1693: 1688: 1683: 1677: 1675: 1674:Proprioception 1671: 1670: 1668: 1667: 1662: 1657: 1652: 1646: 1644: 1640: 1639: 1637: 1636: 1631: 1626: 1621: 1616: 1611: 1606: 1600: 1598: 1592: 1591: 1589: 1588: 1583: 1578: 1573: 1567: 1565: 1559: 1558: 1556: 1555: 1550: 1545: 1540: 1535: 1530: 1525: 1519: 1517: 1511: 1510: 1508: 1507: 1502: 1497: 1492: 1487: 1481: 1479: 1473: 1472: 1470: 1469: 1464: 1459: 1454: 1449: 1444: 1439: 1434: 1429: 1424: 1419: 1413: 1411: 1405: 1404: 1402: 1401: 1396: 1391: 1386: 1381: 1376: 1371: 1366: 1361: 1356: 1351: 1342: 1337: 1332: 1327: 1322: 1317: 1311: 1309: 1300: 1296: 1295: 1292: 1291: 1289: 1288: 1283: 1277: 1275: 1269: 1268: 1266: 1265: 1260: 1254: 1252: 1250:Thermoreceptor 1246: 1245: 1243: 1242: 1237: 1232: 1230:Taste receptor 1226: 1224: 1218: 1217: 1215: 1214: 1209: 1204: 1199: 1194: 1189: 1183: 1181: 1177: 1176: 1174: 1173: 1168: 1163: 1158: 1153: 1148: 1143: 1138: 1133: 1127: 1125: 1116: 1108: 1107: 1104: 1103: 1101: 1100: 1095: 1090: 1084: 1082: 1076: 1075: 1073: 1072: 1067: 1061: 1059: 1053: 1052: 1050: 1049: 1044: 1039: 1034: 1029: 1024: 1019: 1014: 1008: 1006: 997: 991: 990: 987: 986: 984: 983: 978: 973: 968: 963: 958: 956:Proprioception 952: 950: 944: 943: 940: 939: 937: 936: 935: 934: 929: 924: 914: 909: 904: 899: 894: 888: 886: 882: 881: 879: 878: 873: 868: 863: 858: 853: 847: 845: 839: 838: 836: 835: 830: 828:Trigeminal (V) 825: 820: 815: 810: 805: 799: 797: 786: 785: 783: 782: 777: 772: 767: 762: 757: 751: 749: 743: 742: 740: 739: 734: 729: 724: 719: 714: 708: 706: 704:Sensory organs 697: 688: 682: 681: 678: 677: 675: 674: 669: 664: 659: 654: 649: 644: 638: 636: 630: 629: 627: 626: 621: 616: 611: 606: 600: 598: 589: 579: 578: 567: 566: 559: 552: 544: 536: 535: 508:(3): 254–260. 484: 459: 398: 386: 364: 352: 330: 286: 285: 283: 280: 275: 231: 228: 206: 203: 137: 134: 125: 122: 85:, joining the 66: 63: 59:A delta fibers 40:sensory neuron 29:thermoreceptor 15: 9: 6: 4: 3: 2: 1801: 1800: 1789: 1786: 1785: 1783: 1768: 1765: 1764: 1762: 1758: 1748: 1745: 1743: 1740: 1738: 1735: 1733: 1732:Hallucination 1730: 1728: 1727:Derealization 1725: 1723: 1720: 1718: 1715: 1713: 1710: 1709: 1707: 1703: 1697: 1694: 1692: 1689: 1687: 1684: 1682: 1681:Asomatognosia 1679: 1678: 1676: 1672: 1666: 1663: 1661: 1658: 1656: 1653: 1651: 1648: 1647: 1645: 1641: 1635: 1632: 1630: 1627: 1625: 1622: 1620: 1619:Hyperesthesia 1617: 1615: 1612: 1610: 1607: 1605: 1604:Astereognosis 1602: 1601: 1599: 1597: 1593: 1587: 1584: 1582: 1579: 1577: 1574: 1572: 1569: 1568: 1566: 1564: 1560: 1554: 1551: 1549: 1546: 1544: 1541: 1539: 1536: 1534: 1531: 1529: 1526: 1524: 1521: 1520: 1518: 1516: 1512: 1506: 1503: 1501: 1500:Labyrinthitis 1498: 1496: 1493: 1491: 1488: 1486: 1483: 1482: 1480: 1478: 1474: 1468: 1465: 1463: 1460: 1458: 1455: 1453: 1450: 1448: 1445: 1443: 1440: 1438: 1435: 1433: 1430: 1428: 1425: 1423: 1420: 1418: 1415: 1414: 1412: 1410: 1406: 1400: 1397: 1395: 1392: 1390: 1387: 1385: 1382: 1380: 1377: 1375: 1372: 1370: 1367: 1365: 1362: 1360: 1357: 1355: 1352: 1350: 1346: 1343: 1341: 1338: 1336: 1333: 1331: 1328: 1326: 1323: 1321: 1318: 1316: 1313: 1312: 1310: 1308: 1304: 1301: 1297: 1287: 1284: 1282: 1279: 1278: 1276: 1274: 1270: 1264: 1261: 1259: 1256: 1255: 1253: 1251: 1247: 1241: 1238: 1236: 1233: 1231: 1228: 1227: 1225: 1223: 1222:Chemoreceptor 1219: 1213: 1210: 1208: 1205: 1203: 1200: 1198: 1195: 1193: 1190: 1188: 1185: 1184: 1182: 1180:Photoreceptor 1178: 1172: 1169: 1167: 1166:Slit sensilla 1164: 1162: 1159: 1157: 1154: 1152: 1149: 1147: 1144: 1142: 1139: 1137: 1134: 1132: 1129: 1128: 1126: 1124: 1120: 1117: 1115: 1109: 1099: 1096: 1094: 1091: 1089: 1086: 1085: 1083: 1081: 1077: 1071: 1068: 1066: 1063: 1062: 1060: 1058: 1054: 1048: 1045: 1043: 1040: 1038: 1035: 1033: 1030: 1028: 1025: 1023: 1020: 1018: 1015: 1013: 1010: 1009: 1007: 1005: 1001: 998: 996: 992: 982: 981:Visceral pain 979: 977: 974: 972: 969: 967: 964: 962: 959: 957: 954: 953: 951: 949: 945: 933: 932:thermoception 930: 928: 925: 923: 920: 919: 918: 915: 913: 910: 908: 905: 903: 900: 898: 895: 893: 890: 889: 887: 883: 877: 874: 872: 869: 867: 864: 862: 859: 857: 854: 852: 851:Visual cortex 849: 848: 846: 844: 840: 834: 831: 829: 826: 824: 821: 819: 816: 814: 813:Olfactory (I) 811: 809: 806: 804: 801: 800: 798: 796: 795:spinal nerves 792: 787: 781: 778: 776: 773: 771: 768: 766: 763: 761: 758: 756: 753: 752: 750: 748: 744: 738: 735: 733: 730: 728: 725: 723: 720: 718: 715: 713: 710: 709: 707: 705: 701: 698: 696: 692: 689: 687: 683: 673: 670: 668: 665: 663: 660: 658: 655: 653: 652:Consciousness 650: 648: 645: 643: 640: 639: 637: 635: 631: 625: 622: 620: 617: 615: 612: 610: 607: 605: 602: 601: 599: 597: 593: 590: 588: 580: 576: 572: 565: 560: 558: 553: 551: 546: 545: 542: 531: 527: 523: 519: 515: 514:10.1038/nn809 511: 507: 503: 502: 496: 488: 473: 469: 463: 455: 451: 446: 441: 437: 433: 429: 425: 421: 417: 413: 409: 402: 389: 383: 379: 375: 368: 355: 349: 345: 341: 334: 326: 322: 318: 314: 310: 306: 305: 299: 291: 287: 279: 273: 267: 265: 261: 257: 253: 249: 243: 241: 237: 227: 225: 221: 217: 212: 202: 199: 195: 191: 187: 182: 175: 171: 167: 163: 159: 155: 151: 147: 142: 133: 131: 121: 119: 115: 111: 107: 103: 98: 96: 92: 88: 84: 80: 76: 72: 62: 60: 56: 53: 49: 45: 41: 37: 34: 30: 21: 1665:Phantom pain 1650:Hyperalgesia 1624:Hypoesthesia 1442:Hearing loss 1263:TRP channels 1249: 1240:Osmoreceptor 1207:Photopigment 1131:Baroreceptor 1070:Gravitropism 1042:Frog hearing 1022:Echolocation 818:Facial (VII) 505: 499: 487: 476:. Retrieved 474:. 2017-04-22 471: 462: 415: 411: 401: 391:, retrieved 377: 367: 357:, retrieved 343: 333: 308: 302: 290: 268: 244: 233: 208: 205:Distribution 178: 127: 118:feed-forward 99: 68: 52:unmyelinated 28: 26: 1747:Synesthesia 1655:Hypoalgesia 1629:Paresthesia 1614:Formication 1609:CMT disease 1576:Hypergeusia 1399:Visual snow 1374:Photophobia 1369:Papilledema 1359:Oscillopsia 1345:Hemeralopia 1212:Aureochrome 1047:Toad vision 971:Suffocation 885:Perceptions 472:Science ABC 307:(Article). 260:P-type pump 256:Na/K-ATPase 211:nociceptors 79:dorsal horn 75:grey matter 44:temperature 1767:Pareidolia 1722:Allochiria 1705:Multimodal 1586:Parageusia 1581:Hypogeusia 1553:Phantosmia 1533:Hyperosmia 1477:Vestibular 1457:Palinopsia 1417:Amblyaudia 1364:Palinopsia 1349:Nyctalopia 1273:Nociceptor 1080:Artificial 803:Optic (II) 634:Perception 583:Processes 575:perception 478:2023-09-06 414:(Review). 393:2023-09-13 359:2023-06-21 282:References 1563:Gustatory 1515:Olfactory 1379:Photopsia 1325:Amaurosis 1299:Disorders 1192:Cone cell 1111:Types of 722:Inner ear 657:Cognition 647:Awareness 596:Sensation 571:Sensation 436:1933-6969 422:: 73–81. 186:capsaicin 124:Structure 83:decussate 1782:Category 1548:Parosmia 1538:Hyposmia 1528:Dysosmia 1467:Tinnitus 1409:Auditory 1384:Polyopia 1340:Diplopia 1197:Rod cell 995:Nonhuman 948:Internal 789:Sensory 695:External 604:Stimulus 587:concepts 530:21291629 522:11836533 454:25868381 412:Channels 136:Function 95:thalamus 65:Location 55:C-fibres 36:receptor 1717:Agnosia 1596:Tactile 1571:Ageusia 1523:Anosmia 1485:Vertigo 1389:Scotoma 1330:Anopsia 791:cranial 662:Feeling 445:4594430 224:bladder 198:menthol 93:of the 77:of the 1307:Visual 1258:Cilium 1004:Animal 976:Nausea 966:Thirst 961:Hunger 833:Spinal 672:Qualia 528:  520:  452:  442:  434:  384:  350:  325:114608 323:  220:tongue 216:cornea 181:cornea 106:cornea 1202:ipRGC 1057:Plant 917:Touch 732:Mouth 686:Human 526:S2CID 432:eISSN 418:(2). 252:KCNK4 194:TRPM8 190:TRPV1 174:TRPV2 166:TRPM3 162:TRPV1 158:TRPV3 154:TRPV4 150:TRPM8 146:TRPA1 33:sense 1737:HSAN 1712:Aura 1490:BPPV 1347:and 793:and 737:Skin 727:Nose 717:Ears 712:Eyes 585:and 573:and 518:PMID 450:PMID 382:ISBN 348:ISBN 321:PMID 170:ANO1 108:and 510:doi 440:PMC 424:doi 313:doi 278:). 104:), 1784:: 524:. 516:. 504:. 498:. 470:. 448:. 438:. 430:. 410:. 376:, 342:, 319:. 309:42 301:. 222:, 218:, 172:, 168:, 164:, 160:, 156:, 152:, 148:, 97:. 27:A 563:e 556:t 549:v 532:. 512:: 506:5 481:. 456:. 426:: 416:9 327:. 315:: 276:A

Index


sense
receptor
sensory neuron
temperature
peripheral nervous system
unmyelinated
C-fibres
A delta fibers
Lissauer's tract
grey matter
dorsal horn
decussate
spinothalamic tract
ventral posterolateral nucleus
thalamus
cutaneous receptors
cornea
urinary bladder
thermoregulation
feed-forward
free –non-specialized– endings

TRPA1
TRPM8
TRPV4
TRPV3
TRPV1
TRPM3
ANO1

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