299:
276:
198:
173:
1639:
potency, species specificity and mechanism of inhibition. While the earliest inhibitors, such as HC-030031, were lower potency (micromolar inhibition) and had limited TRPA1 specificity, the more recent discovery of highly potent inhibitors with low nanomolar inhibition constants, such as A-967079 and ALGX-2542 as well as high selectivity among other members the TRP superfamily and lack of interaction with other targets have provided valuable tool compounds and candidates for future drug development.
557:
550:
305:
204:
1662:(SPMs) class of metabolites that function to resolve diverse inflammatory reactions and diseases in animal models and, it is proposed, in humans. These SPMs also damp pain perception arising from various inflammation-based causes in animal models. The mechanism behind their pain-dampening effect involves the inhibition of TRPA1, probably (in at least certain cases) by an indirect effect wherein they activate another receptor located on neurons or nearby
1285:). Most notably, the site of covalent modification and activation for electrophilic irritants was localized to a tertiary structural feature on the membrane-proximal intracellular face of the channel, which has been termed the 'allosteric nexus', and which is composed of a cysteine-rich linker domain and the eponymous TRP domain. Breakthrough research combining cryo-electron microscopy and
1638:
A number of small molecule inhibitors (antagonists) have been discovered which have been shown to block the function of TRPA1. At the cellular level, assays that measure agonist-activated inhibition of TRPA1-mediated calcium fluxes and electrophysiological assays have been used to characterize the
1298:
activation by the second messenger calcium, the structure of the channel in complex with calcium localized the binding site for this ion and functional studies demonstrated that this site controls the various different effects of calcium on the channel – namely potentiation, desensitization, and
1167:
and is believed to function as a mechanical and chemical stress sensor. One of the specific functions of this protein studies involves a role in the detection, integration and initiation of pain signals in the peripheral nervous system. It can be activated at sites of tissue injury or sites of
1346:
Oxalate, a metabolite of an anti cancer drug oxaliplatin, has been demonstrated to inhibit prolyl hydroxylase, which endows cold-insensitive human TRPA1 with pseudo cold sensitivity (via reactive oxygen generation from mitochondria). This may cause a characteristic side-effect of oxaliplatin
1297:
act step-wise to modify two critical cysteine residues in the allosteric nexus. Upon covalent attachment, the allosteric nexus adopts a conformational change that is propagated to the channel's pore, dilating it to permit cation influx and subsequent cellular depolarization. With respect to
1150:
located on the plasma membrane of many human and animal cells. This ion channel is best known as a sensor for pain, cold and itch in humans and other mammals, as well as a sensor for environmental irritants giving rise to other protective responses (tears, airway resistance, and cough).
52:
1310:
In 2008, it was observed that caffeine suppresses activity of human TRPA1, but it was found that mouse TRPA1 channels expressed in sensory neurons cause an aversion to drinking caffeine-containing water, suggesting that the TRPA1 channels mediate the perception of caffeine.
3762:
Gijsen HJ, Berthelot D, Zaja M, Brône B, Geuens I, Mercken M (October 2010). "Analogues of morphanthridine and the tear gas dibenzoxazepine (CR) as extremely potent activators of the human transient receptor potential ankyrin 1 (TRPA1) channel".
1314:
TRPA1 has also been implicated in airway irritation by cigarette smoke, cleaning supplies and in the skin irritation experienced by some smokers trying to quit by using nicotine replacement therapies such as inhalers, sprays, or patches. A
2562:
4038:
Grilo A, Sáez-Rosas MP, Santos-Morano J, Sánchez E, Moreno-Rey C, Real LM, et al. (January 2011). "Identification of genetic factors associated with susceptibility to angiotensin-converting enzyme inhibitors-induced cough".
1235:. TRPA1 knockout mice showed near complete attenuation of nocifensive behaviors to formalin, tear-gas and other reactive chemicals . TRPA1 antagonists are effective in blocking pain behaviors induced by inflammation (complete
8458:
7594:
7329:
312:
211:
1323:
suffers from debilitating upper-body pain starting in infancy that is usually triggered by fasting or fatigue (illness, cold temperature, and physical exertion being contributory factors). A gain-of-function
2476:
Ryckmans T, Aubdool AA, Bodkin JV, Cox P, Brain SD, Dupont T, et al. (August 2011). "Design and pharmacological evaluation of PF-4840154, a non-electrophilic reference agonist of the TrpA1 channel".
1630:) was discovered; it was shown to bind TRPA1 non-covalently in the same region as electrophiles and act as a gating modifier toxin for the receptor, stabilizing the channel in an open conformation.
6751:
2037:
Clapham DE, Julius D, Montell C, Schultz G (December 2005). "International Union of
Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels".
1355:
TRPA1 can be considered to be one of the most promiscuous TRP ion channels, as it seems to be activated by a large number of noxious chemicals found in many plants, food, cosmetics and pollutants.
1408:
and TRPA1 activation. A dibenzoxazepine derivative substituted by a carboxylic methyl ester at position 10 has been reported to be a potent nonelectrophilic (thiol-unreactive) TRPA1 agonist (EC
3652:
Macpherson LJ, Dubin AE, Evans MJ, Marr F, Schultz PG, Cravatt BF, Patapoutian A (February 2007). "Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines".
2232:
Baraldi PG, Preti D, Materazzi S, Geppetti P (July 2010). "Transient receptor potential ankyrin 1 (TRPA1) channel as emerging target for novel analgesics and anti-inflammatory agents".
1242:
Although it is not fully confirmed whether noxious cold sensation is mediated by TRPA1 in vivo, several recent studies clearly demonstrated cold activation of TRPA1 channels in vitro.
8219:
1168:
inflammation directly by endogenous mediators or indirectly as a downstream target via signaling from a number of distinct G-protein coupled receptors (GPCRs), such as bradykinin.
6983:
6744:
2267:
Brône B, Peeters PJ, Marrannes R, Mercken M, Nuydens R, Meert T, Gijsen HJ (September 2008). "Tear gasses CN, CR, and CS are potent activators of the human TRPA1 receptor".
1850:
1432:
enabling membrane permeation result in a potent TRPA1 agonistic effect, but thiol adduct formation is neither sufficient nor necessary for TRPA1 activation. The pyrimidine
6737:
1609:
responses. Its mechanism of action does not appear to involve direct binding to TRPA1 but rather the indirect activation and/or sensitization of TRPA1 as well as
5292:
1559:
responses of mice to skin inflammation. In this animal model of pain perception, the hepoxilins are released in the spinal cord directly activate TRPA (and also
6202:
7937:
7222:
6956:
5937:
5189:
5122:
4205:
Pryde DC, Marron B, West CG, Reister S, Amato G, Yoger K, et al. (2016-11-08). "The discovery of a potent series of carboxamide TRPA1 antagonists".
845:
8165:
3859:"Systematic analysis of rat 12/15-lipoxygenase enzymes reveals critical role for spinal eLOX3 hepoxilin synthase activity in inflammatory hyperalgesia"
826:
134:
3989:
4141:"Novel TRPA1 Antagonists are Multimodal Blockers of Human TRPA1 Channels: Drug Candidates for Treatment of Familial Episodic Pain Syndrome (FEPS)"
7461:
2610:"Dose-response study of topical allyl isothiocyanate (mustard oil) as a human surrogate model of pain, hyperalgesia, and neurogenic inflammation"
2563:"Psychophysical and vasomotor evidence for interdependency of TRPA1 and TRPV1-evoked nociceptive responses in human skin: an experimental study"
7466:
1975:
8548:
8408:
7420:
7349:
1957:
7599:
4525:
1428:(10 nM) 'gases') were found to be thiol-reactive TRPA1 agonists. This study found that chemical reactivity with thiols in combination with
1567:-HpETE, which is the direct precursor to HxA3 and HxB3 in the ALOX12 pathway, may act only after being converted to these hepoxilins. The
8403:
8264:
7659:
7558:
7511:
7441:
49:
1343:
does in the spinal cord of mice, causing an antinociceptive effect. This is suggested as the antinociceptive mechanism for paracetamol.
8508:
8523:
1053:
2803:"Species-specific pharmacology of Trichloro(sulfanyl)ethyl benzamides as transient receptor potential ankyrin 1 (TRPA1) antagonists"
1060:
7501:
3208:"Cigarette smoke-induced neurogenic inflammation is mediated by alpha,beta-unsaturated aldehydes and the TRPA1 receptor in rodents"
3800:"Spinal 12-lipoxygenase-derived hepoxilin A3 contributes to inflammatory hyperalgesia via activation of TRPV1 and TRPA1 receptors"
3543:"Sensory characterization of the irritant properties of oleocanthal, a natural anti-inflammatory agent in extra virgin olive oils"
7740:
7712:
6133:
6116:
6111:
6106:
6101:
2218:
7379:
6138:
5236:
4508:
3494:"Unusual pungency from extra-virgin olive oil is attributable to restricted spatial expression of the receptor of oleocanthal"
7766:
7732:
3427:
2312:"Transient receptor potential ankyrin 1 antagonists block the noxious effects of toxic industrial isocyanates and tear gases"
2194:
1995:"An ankyrin-like protein with transmembrane domains is specifically lost after oncogenic transformation of human fibroblasts"
1289:
later elucidated the molecular mechanism of how the channel functions as a broad-spectrum irritant detector. With respect to
1282:
1940:
8601:
6760:
6190:
5371:
1160:
8503:
7619:
7359:
6088:
5109:
1919:
1293:, which activate the channel by covalent modification of two cysteines in the allosteric nexus, it was shown that these
5874:
1659:
2758:
Sawada Y, Hosokawa H, Hori A, Matsumura K, Kobayashi S (July 2007). "Cold sensitivity of recombinant TRPA1 channels".
1339:(acetaminophen) have been demonstrated to bind to the TRPA1 receptors, which may desensitize the receptors in the way
4182:
A Novel Class of Potent, Allosteric TRPA1 Antagonists
Reverse Hyperalgesia in Multiple Rat Models of Neuropathic Pain
1299:
298:
1444:= 97 nM) TRPA1 channels. This compound elicits nociception in a mouse model through TRPA1 activation. Furthermore,
1265:
was employed to obtain a three-dimensional structure of TRPA1. This work revealed that the channel assembles as a
8581:
7894:
6467:
5466:
5244:
4560:
1944:
1923:
1760:
1512:
275:
3492:
Peyrot des
Gachons C, Uchida K, Bryant B, Shima A, Sperry JB, Dankulich-Nagrudny L, et al. (January 2011).
3306:"TRPA1 mediates spinal antinociception induced by acetaminophen and the cannabinoid Δ(9)-tetrahydrocannabiorcol"
8468:
7889:
7884:
7334:
6489:
3705:"The general anesthetic propofol excites nociceptors by activating TRPV1 and TRPA1 rather than GABAA receptors"
890:
7869:
7864:
6811:
6698:
4609:
1262:
871:
8577:
7854:
7415:
6064:
4976:
2852:
Gracheva EO, Ingolia NT, Kelly YM, Cordero-Morales JF, Hollopeter G, Chesler AT, et al. (April 2010).
197:
172:
114:
2911:"Molecular Evolution of the Infrared Sensory Gene TRPA1 in Snakes and Implications for Functional Studies"
1269:, and possesses several structural features that hint at its complex regulation by irritants, cytoplasmic
6339:
3355:"Cold sensitivity of TRPA1 is unveiled by the prolyl hydroxylation blockade-induced sensitization to ROS"
1484:
311:
210:
8606:
4517:
4501:
1602:
1599:
1452:, the pungent component of mustard oil, for screening purposes. Other TRPA1 channel activators include
1250:
3798:
Gregus AM, Doolen S, Dumlao DS, Buczynski MW, Takasusuki T, Fitzsimmons BL, et al. (April 2012).
304:
203:
6693:
4903:
3913:
Koivisto A, Chapman H, Jalava N, Korjamo T, Saarnilehto M, Lindstedt K, Pertovaara A (January 2014).
2658:
McNamara CR, Mandel-Brehm J, Bautista DM, Siemens J, Deranian KL, Zhao M, et al. (August 2007).
1594:
Studies with mice, guinea pigs, and human tissues indicate that another arachidonic acid metabolite,
1369:
appears to be responsible for the pungent or "peppery" sensation in the back of the throat caused by
3304:
Andersson DA, Gentry C, Alenmyr L, Killander D, Lewis SE, Andersson A, et al. (November 2011).
2609:
7969:
7879:
7874:
7859:
7676:
7176:
6806:
6801:
6683:
4944:
4820:
4486:
4480:
4232:
Qu Q, Xuan W, Fan GH (January 2015). "Roles of resolvins in the resolution of acute inflammation".
2416:
Talavera K, Gees M, Karashima Y, Meseguer VM, Vanoirbeek JA, Damann N, et al. (October 2009).
1785:
1588:
1036:
985:
122:
101:
4476:
4085:
Lin King JV, Emrick JJ, Kelly MJ, Herzig V, King GF, Medzihradszky KF, Julius D (September 2019).
8160:
7942:
6688:
3445:"Sensory detection and responses to toxic gases: mechanisms, health effects, and countermeasures"
1810:
1294:
1270:
1583:-eicosatrienoic acid (5,6-EET) made by the metabolism of arachidonic acid by any one of several
1388:
chemicals that have been shown to activate the TRPA1 receptor via the formation of a reversible
1032:
1011:
981:
960:
8463:
8310:
8027:
7899:
7805:
7171:
6816:
6719:
4711:
4698:
4685:
4665:
4652:
4617:
1845:
1800:
4426:"The resolution code of acute inflammation: Novel pro-resolving lipid mediators in resolution"
8611:
8138:
4494:
4003:
Maher SA, Dubuis ED, Belvisi MG (June 2011). "G-protein coupled receptors regulating cough".
1862:
1815:
1621:
3857:
Gregus AM, Dumlao DS, Wei SC, Norris PC, Catella LC, Meyerstein FG, et al. (May 2013).
8518:
8339:
8281:
8210:
8118:
8071:
7506:
7369:
7307:
7287:
7161:
6849:
4592:
3811:
3703:
Fischer MJ, Leffler A, Niedermirtl F, Kistner K, Eberhardt M, Reeh PW, Nau C (2010-11-05).
3661:
3603:
3366:
3317:
3111:
3046:
2989:
2922:
2865:
2671:
2276:
1714:
1655:
1613:
receptors. Genetic polymorphism in the EP3 receptor (rs11209716), has been associated with
1449:
1329:
1236:
1172:
186:
142:
3414:. Topics in Medicinal Chemistry. Vol. 23. Springer Berlin Heidelberg. pp. 1–41.
8:
8423:
8343:
8285:
8243:
8185:
7953:
7132:
4190:
3206:
Andrè E, Campi B, Materazzi S, Trevisani M, Amadesi S, Massi D, et al. (July 2008).
1835:
1425:
1319:
of TRPA1 was found to be the cause of a hereditary episodic pain syndrome. A family from
1219:
in humans. This sub-population of peripheral C-fibers is considered important sensors of
1216:
3815:
3665:
3607:
3370:
3321:
3159:"Breathtaking TRP channels: TRPA1 and TRPV1 in airway chemosensation and reflex control"
3115:
3050:
2993:
2926:
2869:
2675:
2280:
8304:
8170:
7965:
7911:
7476:
7150:
7042:
6828:
6775:
6059:
4935:
4582:
4450:
4425:
4401:
4376:
4352:
4325:
4301:
4276:
4257:
4162:
4111:
4086:
4064:
3885:
3858:
3834:
3799:
3739:
3704:
3685:
3626:
3591:
3567:
3542:
3518:
3493:
3469:
3444:
3387:
3354:
3281:
3256:
3232:
3207:
3183:
3158:
3134:
3099:
3080:
3067:
3034:
3010:
2977:
2953:
2910:
2886:
2853:
2829:
2802:
2783:
2694:
2659:
2640:
2590:
2538:
2513:
2455:
2390:
2365:
2338:
2311:
2219:"Entrez Gene: TRPA1 transient receptor potential cation channel, subfamily A, member 1"
2159:
2062:
1820:
1651:
1626:
1274:
146:
105:, ANKTM1, FEPS, transient receptor potential cation channel subfamily A member 1, FEPS1
4087:"A Cell-Penetrating Scorpion Toxin Enables Mode-Specific Modulation of TRPA1 and Pain"
760:
755:
750:
745:
740:
735:
730:
725:
720:
715:
710:
705:
700:
695:
690:
685:
680:
675:
659:
654:
649:
644:
639:
623:
618:
613:
608:
603:
598:
8498:
8021:
7609:
7532:
7523:
7354:
7123:
7078:
7068:
7013:
6966:
6766:
5097:
4455:
4406:
4357:
4306:
4249:
4166:
4116:
4056:
4020:
3971:
3936:
3890:
3839:
3780:
3744:
3726:
3677:
3631:
3572:
3523:
3474:
3423:
3392:
3353:
Miyake T, Nakamura S, Zhao M, So K, Inoue K, Numata T, et al. (September 2016).
3335:
3286:
3237:
3188:
3139:
3084:
3072:
3015:
2958:
2940:
2891:
2834:
2801:
Klionsky L, Tamir R, Gao B, Wang W, Immke DC, Nishimura N, Gavva NR (December 2007).
2775:
2740:
2699:
2632:
2582:
2543:
2494:
2447:
2417:
2395:
2343:
2292:
2249:
2200:
2190:
2151:
2106:
2054:
2016:
1614:
1548:
1417:
1404:, which is known to cause pain on injection into a vein, a side effect attributed to
1316:
1286:
1232:
1184:
94:
42:
4261:
4157:
4140:
4068:
3255:
Kremeyer B, Lopera F, Cox JJ, Momin A, Rugiero F, Marsh S, et al. (June 2010).
2787:
2644:
2628:
2594:
2578:
2163:
2127:
Højland CR, Andersen HH, Poulsen JN, Arendt-Nielsen L, Gazerani P (September 2015).
2066:
126:
8433:
8199:
8037:
7446:
7107:
6791:
5866:
4847:
4445:
4437:
4396:
4388:
4347:
4337:
4296:
4288:
4241:
4214:
4185:
4152:
4106:
4098:
4048:
4012:
3963:
3926:
3880:
3870:
3829:
3819:
3772:
3734:
3716:
3689:
3669:
3621:
3611:
3562:
3554:
3513:
3509:
3505:
3464:
3456:
3415:
3382:
3374:
3325:
3276:
3268:
3227:
3219:
3178:
3170:
3129:
3119:
3062:
3054:
3005:
2997:
2948:
2930:
2881:
2873:
2824:
2814:
2771:
2767:
2730:
2689:
2679:
2624:
2574:
2533:
2529:
2525:
2486:
2459:
2437:
2429:
2385:
2377:
2333:
2323:
2284:
2241:
2182:
2143:
2096:
2046:
2006:
1840:
1595:
1188:
391:
322:
266:
221:
2129:"A human surrogate model of itch utilizing the TRPA1 agonist trans-cinnamaldehyde"
8553:
8473:
8276:
8269:
7671:
7664:
7604:
7516:
7384:
7339:
6886:
6796:
6402:
4542:
4052:
3967:
3272:
2935:
2310:
Bessac BF, Sivula M, von Hehn CA, Caceres AI, Escalera J, Jordt SE (April 2009).
2186:
1729:
1704:
1584:
366:
150:
4326:"Biological Roles of Resolvins and Related Substances in the Resolution of Pain"
4292:
1980:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1962:
National Center for
Biotechnology Information, U.S. National Library of Medicine
8300:
8215:
7985:
7907:
7614:
7146:
7053:
7023:
6916:
6824:
6198:
4885:
4441:
4392:
4102:
4016:
3804:
Proceedings of the
National Academy of Sciences of the United States of America
3596:
Proceedings of the
National Academy of Sciences of the United States of America
3174:
3104:
Proceedings of the
National Academy of Sciences of the United States of America
2735:
2718:
2664:
Proceedings of the
National Academy of Sciences of the United States of America
2490:
2288:
2128:
1825:
1790:
1362:
1176:
1164:
467:
3460:
3058:
556:
8595:
8533:
8513:
8108:
7823:
7654:
7634:
7364:
7252:
7063:
6936:
6853:
6152:
5825:
3730:
3257:"A gain-of-function mutation in TRPA1 causes familial episodic pain syndrome"
3100:"Caffeine activates mouse TRPA1 channels but suppresses human TRPA1 channels"
2944:
1687:
1683:
1429:
1385:
1278:
1208:
585:
6185:
6083:
3824:
3721:
3616:
3558:
3124:
2684:
2011:
1994:
549:
527:
405:
8413:
8229:
8189:
8122:
8112:
8103:
8098:
8041:
7999:
7589:
7374:
7283:
7196:
7008:
7003:
6906:
6505:
5896:
4459:
4410:
4361:
4310:
4253:
4120:
4060:
4024:
3975:
3940:
3894:
3843:
3784:
3748:
3681:
3635:
3576:
3527:
3478:
3396:
3339:
3290:
3241:
3192:
3143:
3076:
3019:
2962:
2895:
2838:
2819:
2779:
2744:
2703:
2636:
2586:
2547:
2498:
2451:
2399:
2364:
Bessac BF, Sivula M, von Hehn CA, Escalera J, Cohn L, Jordt SE (May 2008).
2347:
2296:
2253:
2204:
2155:
2110:
2058:
2020:
1830:
1552:
1290:
1266:
384:
163:
4342:
3956:
Biochimica et
Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
2608:
Andersen HH, Lo Vecchio S, Gazerani P, Arendt-Nielsen L (September 2017).
2147:
2101:
2084:
1171:
Recent studies indicate that TRPA1 is activated by a number of reactive (
1100:
1095:
8453:
8381:
8365:
8233:
8205:
8088:
8032:
7975:
7961:
7649:
7644:
7584:
7313:
7298:
7293:
7247:
7186:
7113:
7093:
7072:
7033:
6896:
6861:
6729:
6435:
6430:
6425:
6420:
6307:
6146:
4521:
3875:
3419:
3035:"Irritant-evoked activation and calcium modulation of the TRPA1 receptor"
2328:
2181:. Handbook of Experimental Pharmacology. Vol. 179. pp. 347–62.
1724:
1686:
have been proposed to be the receptors through which SPMs may operate to
1476:
1397:
1366:
1336:
1332:
causes the channel to be overly sensitive to pharmacological activation.
1220:
1147:
935:
916:
4377:"Emerging roles of resolvins in the resolution of inflammation and pain"
3673:
3378:
3001:
2877:
2607:
8443:
8334:
8249:
8239:
8195:
8179:
8175:
8066:
7932:
7800:
7783:
7681:
7527:
7455:
7451:
7398:
7344:
7303:
7128:
7118:
7103:
6971:
6881:
6415:
5781:
5149:
5117:
4245:
4218:
3931:
3914:
3330:
3305:
2719:"Increasingly irritable and close to tears: TRPA1 in inflammatory pain"
2442:
1805:
1795:
1744:
1445:
1433:
1384:
have been reported as TRPA1 agonists, most of the known activators are
1246:
1204:
746:
detection of mechanical stimulus involved in sensory perception of pain
283:
180:
130:
7837:
7695:
7266:
3776:
2245:
2050:
71:
8558:
8543:
8538:
8488:
8483:
8128:
8047:
8005:
7995:
7232:
7097:
6500:
6410:
3223:
2381:
1754:
1667:
1663:
1643:
1556:
1465:
1370:
1359:
1340:
790:
681:
detection of chemical stimulus involved in sensory perception of pain
350:
337:
249:
236:
138:
6774:
4516:
2433:
2126:
2085:"Human surrogate models of histaminergic and non-histaminergic itch"
8493:
8478:
8447:
8437:
8427:
8417:
8398:
8386:
8355:
8350:
8314:
8225:
8078:
8017:
7989:
7979:
7957:
7639:
7624:
7548:
7486:
7471:
7431:
7237:
7212:
7165:
7156:
7083:
7049:
6993:
6988:
6950:
6946:
6920:
6910:
6900:
6890:
6876:
6834:
6513:
5861:
4840:
4835:
4830:
4825:
4757:
4752:
4037:
3491:
2978:"Structure of the TRPA1 ion channel suggests regulatory mechanisms"
2851:
2657:
2514:"TRPA1: the central molecule for chemical sensing in pain pathway?"
1880:
1749:
1734:
1719:
1461:
1457:
1401:
1393:
1389:
1325:
1320:
1200:
1196:
1192:
1180:
1084:
4184:. Experimental Biology 2016 Meeting. Vol. 30. p. 927.3.
3954:
Pace-Asciak CR (April 2015). "Pathophysiology of the hepoxilins".
2366:"TRPA1 is a major oxidant sensor in murine airway sensory neurons"
1113:
Transient receptor potential cation channel, subfamily A, member 1
8528:
8393:
8359:
8328:
8292:
8150:
8132:
8052:
8009:
7949:
7917:
7727:
7628:
7579:
7552:
7544:
7491:
7425:
7241:
7217:
7138:
7087:
6976:
6839:
6640:
6397:
6233:
4734:
4729:
4724:
1709:
1647:
1568:
1469:
1381:
1128:
902:
857:
775:
771:
3702:
3033:
Zhao J, Lin King JV, Paulsen CE, Cheng Y, Julius D (July 2020).
2561:
Nielsen TA, Eriksen MA, Gazerani P, Andersen HH (October 2018).
1591:) likewise directly activates TRPA1 to amplify pain perception.
1400:. Another example of a nonelectrophilic agent is the anesthetic
118:
8320:
8296:
8254:
8154:
8082:
7921:
7903:
7761:
7722:
7717:
7495:
7481:
7226:
7142:
7037:
7028:
7018:
6997:
6960:
6931:
6926:
6865:
6857:
6843:
6820:
6317:
6312:
6046:
6041:
5987:
5982:
5798:
5786:
5776:
5771:
5759:
5754:
5749:
5636:
5631:
5626:
5518:
5454:
5449:
5444:
5439:
5434:
5429:
5424:
5359:
5354:
5344:
5339:
5334:
5285:
5280:
5270:
5265:
5142:
5137:
5132:
5127:
5033:
5028:
5023:
5013:
5008:
4998:
4993:
4923:
4918:
4913:
4908:
4811:
4806:
4801:
4796:
4784:
4779:
4774:
4769:
4678:
4645:
4640:
4635:
4630:
3303:
2976:
Paulsen CE, Armache JP, Gao Y, Cheng Y, Julius D (April 2015).
2082:
1739:
1671:
1480:
1453:
1421:
1413:
1377:
1227:
and their activation will under normal conditions give rise to
1224:
1068:
812:
565:
2560:
8324:
8060:
8056:
8013:
7927:
7696:
7563:
7540:
7180:
7057:
6940:
6871:
6551:
6482:
6477:
6472:
6389:
6376:
6371:
6366:
6361:
6356:
6351:
6302:
6295:
6290:
6285:
6280:
6275:
6270:
6265:
6260:
6248:
6243:
6238:
6228:
6223:
6218:
6213:
6128:
6072:
6029:
6024:
6019:
6014:
6009:
6004:
5999:
5977:
5972:
5967:
5962:
5957:
5952:
5947:
5928:
5923:
5918:
5913:
5901:
5818:
5813:
5808:
5793:
5731:
5726:
5721:
5712:
5707:
5693:
5688:
5679:
5674:
5669:
5660:
5655:
5646:
5641:
5608:
5603:
5598:
5593:
5584:
5575:
5570:
5565:
5556:
5551:
5546:
5541:
5532:
5527:
5513:
5508:
5503:
5498:
5493:
5488:
5483:
5419:
5414:
5409:
5404:
5399:
5394:
5389:
5384:
5349:
5319:
5314:
5309:
5304:
5275:
5224:
5219:
5214:
5209:
5199:
5194:
5174:
5159:
5154:
5069:
5064:
5059:
5054:
5038:
5018:
5003:
4964:
4959:
4954:
4949:
4857:
4852:
4575:
4570:
4565:
3540:
2415:
2231:
2083:
Andersen HH, Elberling J, Arendt-Nielsen L (September 2015).
1675:
1610:
1606:
1560:
1405:
1212:
3915:"TRPA1: a transducer and amplifier of pain and inflammation"
3912:
3592:"TRP channel activation by reversible covalent modification"
3590:
Hinman A, Chuang HH, Bautista DM, Julius D (December 2006).
3205:
2363:
2266:
8259:
8093:
7838:
7784:
7745:
7436:
7399:
7267:
6631:
6626:
6621:
6611:
6606:
6601:
6591:
6586:
6581:
6576:
6571:
6566:
6561:
6546:
6541:
6536:
6531:
6526:
6521:
6460:
6455:
6450:
6445:
6440:
6346:
6334:
6329:
6324:
6255:
6208:
6172:
6167:
6162:
6157:
5884:
5702:
5260:
4597:
4587:
3797:
3541:
Cicerale S, Breslin PA, Beauchamp GK, Keast RS (May 2009).
2757:
2309:
2036:
1679:
1228:
1140:
3589:
2418:"Nicotine activates the chemosensory cation channel TRPA1"
5204:
5164:
4084:
1436:
is a potent, non-covalent activator of both the human (EC
3761:
3651:
3032:
2475:
1551:) directly activate TRPA1 and thereby contribute to the
1416:', 0.3 nM) itself, as well as several other tear gases (
374:
8144:
4375:
Ji RR, Xu ZZ, Strichartz G, Serhan CN (November 2011).
4180:
Herz JM, Kesicki E, Tian J, Zhu MX, Thomsen WJ (2016).
4275:
Serhan CN, Chiang N, Dalli J, Levy BD (October 2014).
4204:
3346:
3254:
2975:
4274:
4138:
3856:
3409:
3297:
2176:
1992:
1231:. Indeed, TRPA1 is considered as an attractive pain
539:
6761:
4374:
3352:
2800:
1249:
organs of many snakes, TRPA1 is responsible for the
4277:"Lipid mediators in the resolution of inflammation"
3990:"Reference SNP (refSNP) Cluster Report: Rs11209716"
2908:
2359:
2357:
1277:, cellular co-factors (e.g., inorganic anions like
4179:
4002:
3919:Basic & Clinical Pharmacology & Toxicology
1936:
1934:
1932:
1915:
1913:
1911:
4423:
2854:"Molecular basis of infrared detection by snakes"
1563:) receptors to augment the perception of pain. 12
1376:Although several nonelectrophilic agents such as
321:
220:
8593:
6674:
2909:Geng J, Liang D, Jiang K, Zhang P (2011-12-07).
2354:
3647:
3645:
3410:Boonen B, Startek JB, Talavera K (2016-01-01).
2471:
2469:
2411:
2409:
1929:
1908:
1483:(i.e. arachidonate-12-lipoxygnease) pathway of
751:release of sequestered calcium ion into cytosol
2032:
2030:
1993:Jaquemar D, Schenker T, Trueb B (March 1999).
1941:GRCm38: Ensembl release 89: ENSMUSG00000032769
1347:(cold-triggered acute peripheral neuropathy).
6745:
4502:
4139:Herz JM, Buated W, Thomsen W, Mori Y (2020).
3908:
3906:
3904:
2177:García-Añoveros J, Nagata K (2007). "TRPA1".
4417:
4368:
4323:
4317:
4268:
4225:
4031:
3996:
3755:
3642:
3583:
3485:
3449:Proceedings of the American Thoracic Society
3097:
3091:
2845:
2794:
2751:
2710:
2651:
2601:
2554:
2505:
2479:Bioorganic & Medicinal Chemistry Letters
2466:
2406:
2260:
2225:
2122:
2120:
2078:
2076:
3953:
3442:
3156:
2716:
2179:Transient Receptor Potential (TRP) Channels
2170:
2027:
1986:
1920:GRCh38: Ensembl release 89: ENSG00000104321
1358:Activation of the TRPA1 ion channel by the
6759:
6752:
6738:
4509:
4495:
4281:Cold Spring Harbor Perspectives in Biology
3901:
2511:
1620:More recently, a peptide toxin termed the
1211:" in the body. TRPA1 is co-expressed with
5093:
4538:
4479:at the U.S. National Library of Medicine
4449:
4424:Serhan CN, Chiang N, Dalli J (May 2015).
4400:
4351:
4341:
4300:
4231:
4189:
4156:
4110:
3930:
3884:
3874:
3833:
3823:
3738:
3720:
3625:
3615:
3566:
3517:
3468:
3386:
3329:
3280:
3231:
3182:
3133:
3123:
3066:
3009:
2952:
2934:
2885:
2828:
2818:
2734:
2693:
2683:
2537:
2441:
2389:
2337:
2327:
2117:
2100:
2073:
2010:
1624:from the Australian black rock scorpion (
614:temperature-gated cation channel activity
3534:
1305:
6662:
4881:
1531:-eicosatrienoic acid) and HxB3 (i.e. 10
1515:) and the hepoxilins (Hx), HxA3 (i.e. 8
701:cell surface receptor signaling pathway
8594:
2660:"TRPA1 mediates formalin-induced pain"
1117:transient receptor potential ankyrin 1
6932:CS gas (2-chlorobenzal malononitrile)
6733:
6661:
5846:
5092:
4880:
4537:
4490:
4134:
4132:
4130:
4080:
4078:
3212:The Journal of Clinical Investigation
3157:Bessac BF, Jordt SE (December 2008).
2512:Tai C, Zhu S, Zhou N (January 2008).
2370:The Journal of Clinical Investigation
1163:family. TRPA1 contains 14 N-terminal
660:integral component of plasma membrane
326:
287:
282:
225:
184:
179:
4191:10.1096/fasebj.30.1_supplement.927.3
3248:
3098:Nagatomo K, Kubo Y (November 2008).
1161:transient receptor potential channel
8504:N-(p-Amylcinnamoyl)anthranilic acid
7620:N-(p-Amylcinnamoyl)anthranilic acid
7360:N-(p-Amylcinnamoyl)anthranilic acid
5875:Calcium-activated chloride channels
3709:The Journal of Biological Chemistry
2269:Toxicology and Applied Pharmacology
1999:The Journal of Biological Chemistry
1856:
1633:
1412:= 0.05 nM), while dibenzoxazepine (
711:calcium ion transmembrane transport
676:response to organic cyclic compound
13:
4945:Amiloride-sensitive cation channel
4324:Lim JY, Park CK, Hwang SW (2015).
4127:
4075:
2717:McMahon SB, Wood JN (March 2006).
1693:
1690:TRPs and thereby pain perception.
1660:specialized proresolving mediators
14:
8623:
5847:
4470:
3443:Bessac BF, Jordt SE (July 2010).
1642:Resolvin D1 (RvD1) and RvD2 (see
1460:, while channel blockers include
1350:
1131:that in humans is encoded by the
16:Protein and coding gene in humans
1215:on nociceptive primary afferent
604:calcium-release channel activity
555:
548:
310:
303:
297:
274:
209:
202:
196:
171:
6468:Voltage-dependent anion channel
4561:Inositol trisphosphate receptor
4198:
4173:
4158:10.1096/fasebj.2020.34.s1.02398
4005:Current Opinion in Pharmacology
3982:
3947:
3850:
3791:
3696:
3436:
3403:
3199:
3150:
3026:
2969:
2902:
2629:10.1097/j.pain.0000000000000979
2579:10.1097/j.pain.0000000000001298
2303:
2211:
1513:12-Hydroxyeicosatetraenoic acid
1507:-eicosatetraenoic acid (i.e. 12
1251:detection of infrared radiation
1207:) and is thus considered as a "
1179:, farnesyl thiosalicylic acid,
6490:General bacterial porin family
3765:Journal of Medicinal Chemistry
3510:10.1523/JNEUROSCI.1374-10.2011
2772:10.1016/j.brainres.2007.05.047
2530:10.1523/JNEUROSCI.5237-07.2008
2234:Journal of Medicinal Chemistry
1968:
1950:
1868:
1199:) and non-reactive compounds (
645:integral component of membrane
566:More reference expression data
528:More reference expression data
1:
8578:Receptor/signaling modulators
6927:CR gas (dibenzoxazepine; DBO)
4330:BioMed Research International
4041:Pharmacogenetics and Genomics
1901:
1135:(and in mice and rats by the
731:response to hydrogen peroxide
696:response to organic substance
295:
194:
4053:10.1097/FPC.0b013e328341041c
3968:10.1016/j.bbalip.2014.09.007
3273:10.1016/j.neuron.2010.04.030
2936:10.1371/journal.pone.0028644
2187:10.1007/978-3-540-34891-7_21
1786:4,5-Epoxyeicosatrienoic acid
1256:
7:
8602:Genes on human chromosome 8
8206:Paracetamol (acetaminophen)
7114:Paracetamol (acetaminophen)
6984:Farnesyl thiosalicylic acid
6812:15-Deoxy-Δ-prostaglandin J2
4293:10.1101/cshperspect.a016311
3498:The Journal of Neuroscience
2518:The Journal of Neuroscience
1851:Tetrahydrocannabivarin acid
1698:
1547:-eicosatrienoic acid) (see
1485:arachidonic acid metabolism
1154:
761:ion transmembrane transport
726:protein homotetramerization
10:
8628:
5909:Chloride Channel Accessory
4518:Membrane transport protein
4442:10.1016/j.smim.2015.03.004
4393:10.1016/j.tins.2011.08.005
4234:Cell Biology International
4103:10.1016/j.cell.2019.07.014
4017:10.1016/j.coph.2011.06.005
3175:10.1152/physiol.00026.2008
2736:10.1016/j.cell.2006.03.006
2491:10.1016/j.bmcl.2011.06.035
2289:10.1016/j.taap.2008.04.005
2136:Acta Dermato-Venereologica
2089:Acta Dermato-Venereologica
1658:. They are members of the
1650:1 are metabolites of the
1603:G protein coupled receptor
1295:reactive oxidative species
721:sensory perception of pain
452:mucosa of transverse colon
8571:
8374:
7847:
7836:
7816:
7793:
7782:
7754:
7705:
7694:
7572:
7408:
7397:
7322:
7276:
7265:
7205:
6784:
6773:
6715:
6670:
6657:
6498:
6387:
6183:
6081:
6057:
5859:
5855:
5842:
5465:
5370:
5235:
5108:
5104:
5088:
4975:
4934:
4904:Epithelial sodium channel
4896:
4892:
4876:
4608:
4553:
4549:
4533:
3461:10.1513/pats.201001-004SM
3059:10.1038/s41586-020-2480-9
1976:"Mouse PubMed Reference:"
1958:"Human PubMed Reference:"
1617:-induce cough in humans.
1549:Hepoxilin#Pain perception
1159:TRPA1 is a member of the
1099:
1094:
1090:
1083:
1067:
1048:
1029:
1025:
1008:
1004:
997:
978:
974:
957:
953:
946:
933:
929:
914:
910:
901:
888:
884:
869:
865:
856:
843:
839:
824:
820:
811:
796:
789:
785:
769:
624:identical protein binding
584:
580:
563:
547:
538:
525:
498:glossopharyngeal ganglion
474:
465:
424:mucosa of urinary bladder
412:
403:
373:
365:
361:
344:
331:
294:
273:
264:
260:
243:
230:
193:
170:
161:
157:
112:
109:
99:
92:
87:
68:
63:
46:
41:
36:
32:
28:
23:
7191:Umbellularia californica
4821:Cation channels of sperm
4481:Medical Subject Headings
1589:Epoxyeicosatrienoic acid
1396:residues present in the
1263:cryo-electron microscopy
619:calcium channel activity
8161:N-Arachidonoyl dopamine
7943:Andrographis paniculata
4381:Trends in Neurosciences
3825:10.1073/pnas.1110460109
3722:10.1074/jbc.M110.143958
3617:10.1073/pnas.0609598103
3125:10.1073/pnas.0809769105
2685:10.1073/pnas.0705924104
2039:Pharmacological Reviews
2012:10.1074/jbc.274.11.7325
1811:N-Arachidonoyl dopamine
1598:, operates through its
1061:Chr 1: 14.94 – 14.99 Mb
1054:Chr 8: 72.02 – 72.08 Mb
756:transmembrane transport
428:mucosa of sigmoid colon
8582:Ion channel modulators
8311:Tetrahydrocannabivarin
7806:Tripterygium wilfordii
7172:Tetrahydrocannabiorcol
4430:Seminars in Immunology
2820:10.1186/1744-8069-3-39
1846:Tetrahydrocannabivarin
1801:2-Arachidonoylglycerol
1781:-eicosatetraenoic acid
1535:-hydroxy-11,12-oxido-5
1519:-hydroxy-11,12-oxido-5
1245:In the heat-sensitive
478:lumbar spinal ganglion
8139:Lysophosphatidic acid
4897:Constitutively active
3559:10.1093/chemse/bjp006
3359:Nature Communications
3310:Nature Communications
2148:10.2340/00015555-2103
2102:10.2340/00015555-2146
1816:Palmitoylethanolamide
1622:wasabi receptor toxin
1306:Clinical significance
1281:), and lipids (e.g.,
741:calcium ion transport
8519:Pregnenolone sulfate
8340:Euphorbia resinifera
8282:Euphorbia resinifera
8211:Phenylacetylrinvanil
8171:N-Oleoylethanolamide
8119:Homodihydrocapsaicin
7507:Pregnenolone sulfate
7370:Pregnenolone sulfate
7177:Thiopropanal S-oxide
7162:Tetrahydrocannabinol
6850:Allyl isothiocyanate
4477:TRPA1+protein,+human
4097:(6): 1362–1374.e16.
3876:10.1096/fj.12-217414
3420:10.1007/7355_2015_98
2329:10.1096/fj.08-117812
1715:Allyl isothiocyanate
1656:docosahexaenoic acid
1450:allyl isothiocyanate
1440:= 23 nM) and rat (EC
1330:transmembrane domain
1173:allyl isothiocyanate
686:response to stimulus
609:ion channel activity
289:Chromosome 1 (mouse)
187:Chromosome 8 (human)
64:List of PDB id codes
37:Available structures
8424:Cannabigerolic acid
8186:Nordihydrocapsaicin
8147:(acidic conditions)
6664:By gating mechanism
4343:10.1155/2015/830930
3816:2012PNAS..109.6721G
3715:(45): 34781–34792.
3674:10.1038/nature05544
3666:2007Natur.445..541M
3608:2006PNAS..10319564H
3379:10.1038/ncomms12840
3371:2016NatCo...712840M
3322:2011NatCo...2..551A
3116:2008PNAS..10517373N
3051:2020Natur.585..141Z
3002:10.1038/nature14367
2994:2015Natur.520..511P
2927:2011PLoSO...628644G
2878:10.1038/nature08943
2870:2010Natur.464.1006G
2676:2007PNAS..10413525M
2422:Nature Neuroscience
2281:2008ToxAP.231..150B
1836:Cannabigerolic acid
1125:The Wasabi Receptor
640:stereocilium bundle
440:epithelium of colon
8387:Vernonia tweediana
7966:African blue basil
7938:Bisandrographolide
7524:Steviol glycosides
7477:Hydroxycitronellal
7223:Dehydroligustilide
7043:Angelica acutiloba
6957:Dehydroligustilide
6191:TRP cation channel
6089:CNG cation channel
5372:Tandem pore domain
4583:Ryanodine receptor
4246:10.1002/cbin.10345
4219:10.1039/C6MD00387G
3932:10.1111/bcpt.12138
3331:10.1038/ncomms1559
2813:: 1744-8069–3-39.
1821:Cannabidiolic acid
1652:omega 3 fatty acid
1627:Urodacus manicatus
1300:receptor-operation
891:ENSMUSG00000032769
669:Biological process
633:Cellular component
592:Molecular function
8607:Membrane proteins
8589:
8588:
8567:
8566:
8499:Meclofenamic acid
8305:melegueta peppers
8176:Nonivamide (PAVA)
7912:melegueta peppers
7832:
7831:
7778:
7777:
7690:
7689:
7610:Meclofenamic acid
7533:Stevia rebaudiana
7393:
7392:
7355:Meclofenamic acid
7261:
7260:
7151:melegueta peppers
7124:Phenacyl chloride
7079:N-Methylmaleimide
7069:Methyl salicylate
7014:Hydrogen peroxide
6967:Diallyl disulfide
6829:melegueta peppers
6727:
6726:
6711:
6710:
6707:
6706:
6699:Stretch-activated
6676:Ion channel class
6653:
6652:
6649:
6648:
5838:
5837:
5834:
5833:
5110:Calcium-activated
5098:Potassium channel
5084:
5083:
5080:
5079:
4872:
4871:
4868:
4867:
4213:(11): 2145–2158.
4145:The FASEB Journal
3777:10.1021/jm100477n
3429:978-3-319-48925-4
3045:(7823): 141–145.
2864:(7291): 1006–11.
2573:(10): 1989–2001.
2246:10.1021/jm100062h
2196:978-3-540-34889-4
2051:10.1124/pr.57.4.6
1600:prostaglandin EP3
1317:missense mutation
1287:electrophysiology
1271:second messengers
1237:Freund's adjuvant
1185:hydrogen peroxide
1110:
1109:
1106:
1105:
1079:
1078:
1044:
1043:
1019:
1018:
993:
992:
968:
967:
942:
941:
923:
922:
897:
896:
878:
877:
852:
851:
833:
832:
781:
780:
576:
575:
572:
571:
534:
533:
521:
520:
459:
458:
357:
356:
256:
255:
151:TRPA1 - orthologs
83:
82:
79:
78:
47:Ortholog search:
8619:
8434:Cannabigerovarin
8166:N-Oleoyldopamine
8072:Euodia ruticarpa
8038:Dihydrocapsaicin
7845:
7844:
7841:
7791:
7790:
7787:
7703:
7702:
7699:
7447:Cooling Agent 10
7406:
7405:
7402:
7274:
7273:
7270:
6792:4-Hydroxynonenal
6782:
6781:
6778:
6763:
6754:
6747:
6740:
6731:
6730:
6672:
6671:
6659:
6658:
5867:Chloride channel
5857:
5856:
5844:
5843:
5237:Inward-rectifier
5106:
5105:
5090:
5089:
4894:
4893:
4878:
4877:
4848:Two-pore channel
4551:
4550:
4535:
4534:
4511:
4504:
4497:
4488:
4487:
4464:
4463:
4453:
4421:
4415:
4414:
4404:
4372:
4366:
4365:
4355:
4345:
4321:
4315:
4314:
4304:
4272:
4266:
4265:
4229:
4223:
4222:
4202:
4196:
4195:
4193:
4177:
4171:
4170:
4160:
4136:
4125:
4124:
4114:
4082:
4073:
4072:
4035:
4029:
4028:
4000:
3994:
3993:
3986:
3980:
3979:
3951:
3945:
3944:
3934:
3910:
3899:
3898:
3888:
3878:
3854:
3848:
3847:
3837:
3827:
3795:
3789:
3788:
3759:
3753:
3752:
3742:
3724:
3700:
3694:
3693:
3649:
3640:
3639:
3629:
3619:
3587:
3581:
3580:
3570:
3538:
3532:
3531:
3521:
3489:
3483:
3482:
3472:
3440:
3434:
3433:
3407:
3401:
3400:
3390:
3350:
3344:
3343:
3333:
3301:
3295:
3294:
3284:
3252:
3246:
3245:
3235:
3224:10.1172/JCI34886
3203:
3197:
3196:
3186:
3154:
3148:
3147:
3137:
3127:
3095:
3089:
3088:
3070:
3030:
3024:
3023:
3013:
2973:
2967:
2966:
2956:
2938:
2906:
2900:
2899:
2889:
2849:
2843:
2842:
2832:
2822:
2798:
2792:
2791:
2755:
2749:
2748:
2738:
2714:
2708:
2707:
2697:
2687:
2670:(33): 13525–30.
2655:
2649:
2648:
2623:(9): 1723–1732.
2614:
2605:
2599:
2598:
2558:
2552:
2551:
2541:
2509:
2503:
2502:
2473:
2464:
2463:
2445:
2413:
2404:
2403:
2393:
2382:10.1172/JCI34192
2361:
2352:
2351:
2341:
2331:
2307:
2301:
2300:
2264:
2258:
2257:
2240:(14): 5085–107.
2229:
2223:
2222:
2215:
2209:
2208:
2174:
2168:
2167:
2133:
2124:
2115:
2114:
2104:
2080:
2071:
2070:
2034:
2025:
2024:
2014:
1990:
1984:
1983:
1972:
1966:
1965:
1954:
1948:
1938:
1927:
1917:
1857:Gating Modifiers
1841:Cannabigerovarin
1634:TRPA1 inhibition
1596:Prostaglandin E2
1189:4-hydroxynonenal
1115:, also known as
1092:
1091:
1063:
1056:
1039:
1023:
1022:
1014:
1002:
1001:
998:RefSeq (protein)
988:
972:
971:
963:
951:
950:
927:
926:
908:
907:
882:
881:
863:
862:
837:
836:
818:
817:
787:
786:
716:response to cold
706:response to pain
599:channel activity
582:
581:
568:
559:
552:
545:
544:
530:
482:secondary oocyte
470:
468:Top expressed in
463:
462:
420:secondary oocyte
408:
406:Top expressed in
401:
400:
380:
379:
363:
362:
353:
340:
329:
314:
307:
301:
290:
278:
262:
261:
252:
239:
228:
213:
206:
200:
189:
175:
159:
158:
153:
104:
97:
74:
61:
60:
55:
34:
33:
21:
20:
8627:
8626:
8622:
8621:
8620:
8618:
8617:
8616:
8592:
8591:
8590:
8585:
8563:
8554:Tolfenamic acid
8474:Flufenamic acid
8370:
8277:Resiniferatoxin
8270:Ruta graveolens
8033:Diacyl glycerol
7828:
7812:
7774:
7770:
7750:
7736:
7686:
7672:Tolfenamic acid
7665:Ruta graveolens
7605:Flufenamic acid
7568:
7517:Ruta graveolens
7428:(intracellular)
7389:
7385:Tolfenamic acid
7340:Flufenamic acid
7318:
7294:Diacyl glycerol
7257:
7201:
6887:Cannabichromene
6797:4-Oxo-2-nonenal
6769:
6758:
6728:
6723:
6703:
6666:
6645:
6494:
6393:
6383:
6179:
6077:
6053:
5851:
5830:
5744:
5621:
5478:
5461:
5366:
5330:
5300:
5256:
5248:
5231:
5185:
5100:
5076:
5049:
4988:
4971:
4930:
4888:
4864:
4747:
4719:
4706:
4693:
4673:
4660:
4625:
4604:
4545:
4543:Calcium channel
4529:
4515:
4473:
4468:
4467:
4422:
4418:
4387:(11): 599–609.
4373:
4369:
4322:
4318:
4273:
4269:
4230:
4226:
4203:
4199:
4178:
4174:
4137:
4128:
4083:
4076:
4036:
4032:
4001:
3997:
3988:
3987:
3983:
3952:
3948:
3911:
3902:
3855:
3851:
3796:
3792:
3771:(19): 7011–20.
3760:
3756:
3701:
3697:
3660:(7127): 541–5.
3650:
3643:
3602:(51): 19564–8.
3588:
3584:
3547:Chemical Senses
3539:
3535:
3504:(3): 999–1009.
3490:
3486:
3441:
3437:
3430:
3412:Taste and Smell
3408:
3404:
3351:
3347:
3302:
3298:
3253:
3249:
3204:
3200:
3155:
3151:
3110:(45): 17373–8.
3096:
3092:
3031:
3027:
2988:(7548): 511–7.
2974:
2970:
2907:
2903:
2850:
2846:
2799:
2795:
2756:
2752:
2715:
2711:
2656:
2652:
2612:
2606:
2602:
2559:
2555:
2510:
2506:
2474:
2467:
2434:10.1038/nn.2379
2414:
2407:
2376:(5): 1899–910.
2362:
2355:
2308:
2304:
2265:
2261:
2230:
2226:
2217:
2216:
2212:
2197:
2175:
2171:
2131:
2125:
2118:
2081:
2074:
2035:
2028:
2005:(11): 7325–33.
1991:
1987:
1974:
1973:
1969:
1956:
1955:
1951:
1939:
1930:
1918:
1909:
1904:
1871:
1859:
1730:Cannabichromene
1705:4-Oxo-2-nonenal
1701:
1696:
1694:Ligand examples
1636:
1585:cytochrome P450
1448:is superior to
1443:
1439:
1411:
1353:
1335:Metabolites of
1308:
1259:
1239:and formalin).
1165:ankyrin repeats
1157:
1101:View/Edit Mouse
1096:View/Edit Human
1059:
1052:
1049:Location (UCSC)
1035:
1031:
1010:
984:
980:
959:
872:ENSG00000104321
765:
664:
655:plasma membrane
628:
564:
554:
553:
526:
517:
512:
508:
504:
500:
496:
492:
488:
484:
480:
466:
455:
450:
446:
442:
438:
436:mucosa of ileum
434:
430:
426:
422:
418:
404:
348:
335:
327:
317:
316:
315:
308:
288:
265:Gene location (
247:
234:
226:
216:
215:
214:
207:
185:
162:Gene location (
113:
100:
93:
70:
48:
17:
12:
11:
5:
8625:
8615:
8614:
8609:
8604:
8587:
8586:
8572:
8569:
8568:
8565:
8564:
8562:
8561:
8556:
8551:
8546:
8541:
8536:
8531:
8526:
8521:
8516:
8511:
8506:
8501:
8496:
8491:
8486:
8481:
8476:
8471:
8466:
8461:
8456:
8451:
8441:
8431:
8421:
8411:
8406:
8401:
8396:
8391:
8378:
8376:
8372:
8371:
8369:
8368:
8363:
8353:
8348:
8332:
8318:
8308:
8290:
8274:
8262:
8257:
8252:
8247:
8244:Dorrigo pepper
8237:
8223:
8216:Phorbol esters
8213:
8208:
8203:
8193:
8183:
8173:
8168:
8163:
8158:
8148:
8141:
8136:
8126:
8116:
8106:
8101:
8096:
8091:
8086:
8076:
8064:
8050:
8045:
8035:
8030:
8025:
8003:
7993:
7986:Cannabidivarin
7983:
7973:
7954:camphor laurel
7947:
7935:
7930:
7925:
7915:
7897:
7892:
7887:
7882:
7877:
7872:
7867:
7862:
7857:
7851:
7849:
7842:
7834:
7833:
7830:
7829:
7827:
7826:
7820:
7818:
7814:
7813:
7811:
7810:
7797:
7795:
7788:
7780:
7779:
7776:
7775:
7773:
7772:
7768:
7764:
7758:
7756:
7752:
7751:
7749:
7748:
7743:
7738:
7734:
7730:
7725:
7720:
7715:
7709:
7707:
7700:
7692:
7691:
7688:
7687:
7685:
7684:
7679:
7674:
7669:
7657:
7652:
7647:
7642:
7637:
7632:
7622:
7617:
7615:Mefenamic acid
7612:
7607:
7602:
7597:
7592:
7587:
7582:
7576:
7574:
7570:
7569:
7567:
7566:
7561:
7556:
7537:
7521:
7509:
7504:
7499:
7489:
7484:
7479:
7474:
7469:
7464:
7459:
7449:
7444:
7439:
7434:
7429:
7423:
7418:
7412:
7410:
7403:
7395:
7394:
7391:
7390:
7388:
7387:
7382:
7377:
7372:
7367:
7362:
7357:
7352:
7347:
7342:
7337:
7332:
7326:
7324:
7320:
7319:
7317:
7316:
7311:
7308:St John's wort
7301:
7296:
7291:
7288:St John's wort
7280:
7278:
7271:
7263:
7262:
7259:
7258:
7256:
7255:
7250:
7245:
7235:
7230:
7220:
7215:
7209:
7207:
7203:
7202:
7200:
7199:
7194:
7184:
7174:
7169:
7159:
7154:
7136:
7133:Dorrigo pepper
7126:
7121:
7116:
7111:
7101:
7091:
7081:
7076:
7066:
7061:
7054:Sichuan pepper
7047:
7031:
7026:
7024:Isothiocyanate
7021:
7016:
7011:
7006:
7001:
6991:
6986:
6981:
6969:
6964:
6954:
6944:
6934:
6929:
6924:
6917:Cinnamaldehyde
6914:
6904:
6894:
6884:
6879:
6874:
6869:
6847:
6837:
6832:
6814:
6809:
6804:
6799:
6794:
6788:
6786:
6779:
6771:
6770:
6757:
6756:
6749:
6742:
6734:
6725:
6724:
6716:
6713:
6712:
6709:
6708:
6705:
6704:
6702:
6701:
6696:
6691:
6686:
6680:
6678:
6668:
6667:
6655:
6654:
6651:
6650:
6647:
6646:
6644:
6643:
6638:
6637:
6636:
6635:
6634:
6629:
6624:
6616:
6615:
6614:
6609:
6604:
6596:
6595:
6594:
6589:
6584:
6579:
6574:
6569:
6564:
6556:
6555:
6554:
6549:
6544:
6539:
6534:
6529:
6524:
6510:
6508:
6496:
6495:
6493:
6492:
6487:
6486:
6485:
6480:
6475:
6465:
6464:
6463:
6458:
6453:
6448:
6443:
6438:
6433:
6428:
6423:
6418:
6407:
6405:
6391:
6385:
6384:
6382:
6381:
6380:
6379:
6374:
6369:
6364:
6359:
6354:
6344:
6343:
6342:
6337:
6327:
6322:
6321:
6320:
6315:
6310:
6300:
6299:
6298:
6293:
6288:
6283:
6278:
6273:
6268:
6263:
6253:
6252:
6251:
6246:
6241:
6236:
6231:
6226:
6221:
6216:
6206:
6195:
6193:
6181:
6180:
6178:
6177:
6176:
6175:
6170:
6165:
6160:
6155:
6143:
6142:
6141:
6136:
6131:
6121:
6120:
6119:
6114:
6109:
6104:
6093:
6091:
6079:
6078:
6076:
6075:
6069:
6067:
6065:Proton channel
6055:
6054:
6052:
6051:
6050:
6049:
6044:
6034:
6033:
6032:
6027:
6022:
6017:
6012:
6007:
6002:
5992:
5991:
5990:
5985:
5980:
5975:
5970:
5965:
5960:
5955:
5950:
5940:
5935:
5934:
5933:
5932:
5931:
5926:
5921:
5916:
5906:
5905:
5904:
5899:
5889:
5888:
5887:
5871:
5869:
5853:
5852:
5840:
5839:
5836:
5835:
5832:
5831:
5829:
5828:
5823:
5822:
5821:
5816:
5811:
5801:
5796:
5791:
5790:
5789:
5784:
5779:
5774:
5764:
5763:
5762:
5757:
5752:
5742:
5737:
5736:
5735:
5734:
5729:
5724:
5717:
5716:
5715:
5710:
5705:
5698:
5697:
5696:
5691:
5684:
5683:
5682:
5677:
5672:
5665:
5664:
5663:
5658:
5651:
5650:
5649:
5644:
5639:
5634:
5629:
5619:
5614:
5613:
5612:
5611:
5606:
5601:
5596:
5589:
5588:
5587:
5580:
5579:
5578:
5573:
5568:
5561:
5560:
5559:
5554:
5549:
5544:
5537:
5536:
5535:
5530:
5523:
5522:
5521:
5516:
5511:
5506:
5501:
5496:
5491:
5486:
5476:
5471:
5469:
5463:
5462:
5460:
5459:
5458:
5457:
5452:
5447:
5442:
5437:
5432:
5427:
5422:
5417:
5412:
5407:
5402:
5397:
5392:
5387:
5376:
5374:
5368:
5367:
5365:
5364:
5363:
5362:
5357:
5352:
5347:
5342:
5337:
5328:
5324:
5323:
5322:
5317:
5312:
5307:
5298:
5290:
5289:
5288:
5283:
5278:
5273:
5268:
5263:
5254:
5250:
5246:
5241:
5239:
5233:
5232:
5230:
5229:
5228:
5227:
5222:
5217:
5212:
5207:
5202:
5197:
5192:
5183:
5179:
5178:
5177:
5169:
5168:
5167:
5162:
5157:
5147:
5146:
5145:
5140:
5135:
5130:
5125:
5114:
5112:
5102:
5101:
5086:
5085:
5082:
5081:
5078:
5077:
5075:
5074:
5073:
5072:
5067:
5062:
5057:
5047:
5043:
5042:
5041:
5036:
5031:
5026:
5021:
5016:
5011:
5006:
5001:
4996:
4986:
4981:
4979:
4973:
4972:
4970:
4969:
4968:
4967:
4962:
4957:
4952:
4941:
4939:
4932:
4931:
4929:
4928:
4927:
4926:
4921:
4916:
4911:
4900:
4898:
4890:
4889:
4886:Sodium channel
4874:
4873:
4870:
4869:
4866:
4865:
4863:
4862:
4861:
4860:
4855:
4845:
4844:
4843:
4838:
4833:
4828:
4817:
4816:
4815:
4814:
4809:
4804:
4799:
4789:
4788:
4787:
4782:
4777:
4772:
4762:
4761:
4760:
4755:
4745:
4740:
4739:
4738:
4737:
4732:
4727:
4717:
4709:
4704:
4696:
4691:
4683:
4682:
4681:
4671:
4663:
4658:
4650:
4649:
4648:
4643:
4638:
4633:
4623:
4614:
4612:
4606:
4605:
4603:
4602:
4601:
4600:
4595:
4590:
4580:
4579:
4578:
4573:
4568:
4557:
4555:
4547:
4546:
4531:
4530:
4514:
4513:
4506:
4499:
4491:
4485:
4484:
4472:
4471:External links
4469:
4466:
4465:
4416:
4367:
4316:
4287:(2): a016311.
4267:
4224:
4197:
4172:
4126:
4074:
4030:
3995:
3981:
3946:
3900:
3869:(5): 1939–49.
3849:
3810:(17): 6721–6.
3790:
3754:
3695:
3641:
3582:
3533:
3484:
3435:
3428:
3402:
3345:
3296:
3247:
3218:(7): 2574–82.
3198:
3149:
3090:
3025:
2968:
2921:(12): e28644.
2901:
2844:
2807:Molecular Pain
2793:
2760:Brain Research
2750:
2709:
2650:
2600:
2553:
2524:(5): 1019–21.
2504:
2485:(16): 4857–9.
2465:
2428:(10): 1293–9.
2405:
2353:
2322:(4): 1102–14.
2302:
2259:
2224:
2210:
2195:
2169:
2142:(7): 798–803.
2116:
2072:
2026:
1985:
1967:
1949:
1928:
1906:
1905:
1903:
1900:
1899:
1898:
1895:
1892:
1889:
1886:
1883:
1878:
1875:
1870:
1867:
1866:
1865:
1858:
1855:
1854:
1853:
1848:
1843:
1838:
1833:
1828:
1826:Cannabidivarin
1823:
1818:
1813:
1808:
1803:
1798:
1793:
1791:Cinnamaldehyde
1788:
1783:
1765:-Hydroperoxy-5
1758:
1752:
1747:
1742:
1737:
1732:
1727:
1722:
1717:
1712:
1707:
1700:
1697:
1695:
1692:
1684:NMDA receptors
1635:
1632:
1491:-hydroperoxy-5
1479:formed in the
1441:
1437:
1409:
1352:
1351:Ligand binding
1349:
1328:in the fourth
1307:
1304:
1279:polyphosphates
1258:
1255:
1177:cinnamaldehyde
1156:
1153:
1108:
1107:
1104:
1103:
1098:
1088:
1087:
1081:
1080:
1077:
1076:
1074:
1072:
1065:
1064:
1057:
1050:
1046:
1045:
1042:
1041:
1027:
1026:
1020:
1017:
1016:
1006:
1005:
999:
995:
994:
991:
990:
976:
975:
969:
966:
965:
955:
954:
948:
944:
943:
940:
939:
931:
930:
924:
921:
920:
912:
911:
905:
899:
898:
895:
894:
886:
885:
879:
876:
875:
867:
866:
860:
854:
853:
850:
849:
841:
840:
834:
831:
830:
822:
821:
815:
809:
808:
803:
798:
794:
793:
783:
782:
779:
778:
767:
766:
764:
763:
758:
753:
748:
743:
738:
733:
728:
723:
718:
713:
708:
703:
698:
693:
688:
683:
678:
672:
670:
666:
665:
663:
662:
657:
652:
647:
642:
636:
634:
630:
629:
627:
626:
621:
616:
611:
606:
601:
595:
593:
589:
588:
578:
577:
574:
573:
570:
569:
561:
560:
542:
536:
535:
532:
531:
523:
522:
519:
518:
516:
515:
511:
507:
503:
499:
495:
491:
487:
486:primary oocyte
483:
479:
475:
472:
471:
460:
457:
456:
454:
453:
449:
445:
444:jejunal mucosa
441:
437:
433:
429:
425:
421:
417:
413:
410:
409:
397:
396:
388:
377:
371:
370:
367:RNA expression
359:
358:
355:
354:
346:
342:
341:
333:
330:
325:
319:
318:
309:
302:
296:
292:
291:
286:
280:
279:
271:
270:
258:
257:
254:
253:
245:
241:
240:
232:
229:
224:
218:
217:
208:
201:
195:
191:
190:
183:
177:
176:
168:
167:
155:
154:
111:
107:
106:
98:
90:
89:
85:
84:
81:
80:
77:
76:
66:
65:
57:
56:
45:
39:
38:
30:
29:
26:
25:
15:
9:
6:
4:
3:
2:
8624:
8613:
8610:
8608:
8605:
8603:
8600:
8599:
8597:
8584:
8583:
8579:
8576:
8570:
8560:
8557:
8555:
8552:
8550:
8547:
8545:
8542:
8540:
8537:
8535:
8534:Ruthenium red
8532:
8530:
8527:
8525:
8522:
8520:
8517:
8515:
8514:Niflumic acid
8512:
8510:
8507:
8505:
8502:
8500:
8497:
8495:
8492:
8490:
8487:
8485:
8482:
8480:
8477:
8475:
8472:
8470:
8467:
8465:
8462:
8460:
8457:
8455:
8452:
8449:
8445:
8442:
8439:
8435:
8432:
8429:
8425:
8422:
8419:
8415:
8412:
8410:
8407:
8405:
8402:
8400:
8397:
8395:
8392:
8389:
8388:
8383:
8382:α-Spinasterol
8380:
8379:
8377:
8373:
8367:
8364:
8361:
8357:
8354:
8352:
8349:
8346:
8345:
8341:
8336:
8333:
8330:
8326:
8322:
8319:
8316:
8312:
8309:
8306:
8302:
8298:
8294:
8291:
8288:
8287:
8283:
8278:
8275:
8272:
8271:
8266:
8263:
8261:
8258:
8256:
8253:
8251:
8248:
8245:
8241:
8238:
8235:
8231:
8227:
8224:
8221:
8217:
8214:
8212:
8209:
8207:
8204:
8201:
8197:
8194:
8191:
8187:
8184:
8181:
8177:
8174:
8172:
8169:
8167:
8164:
8162:
8159:
8156:
8152:
8149:
8146:
8142:
8140:
8137:
8134:
8130:
8127:
8124:
8120:
8117:
8114:
8110:
8109:Homocapsaicin
8107:
8105:
8102:
8100:
8097:
8095:
8092:
8090:
8087:
8084:
8080:
8077:
8074:
8073:
8068:
8065:
8062:
8058:
8054:
8051:
8049:
8046:
8043:
8039:
8036:
8034:
8031:
8029:
8026:
8023:
8022:wild bergamot
8019:
8015:
8011:
8007:
8004:
8001:
7997:
7994:
7991:
7987:
7984:
7981:
7977:
7974:
7971:
7970:camphor basil
7967:
7963:
7959:
7955:
7951:
7948:
7945:
7944:
7939:
7936:
7934:
7931:
7929:
7926:
7923:
7919:
7916:
7913:
7909:
7905:
7901:
7898:
7896:
7893:
7891:
7888:
7886:
7883:
7881:
7878:
7876:
7873:
7871:
7868:
7866:
7863:
7861:
7858:
7856:
7853:
7852:
7850:
7846:
7843:
7840:
7835:
7825:
7824:Ruthenium red
7822:
7821:
7819:
7815:
7808:
7807:
7802:
7799:
7798:
7796:
7792:
7789:
7786:
7781:
7771:
7765:
7763:
7760:
7759:
7757:
7753:
7747:
7744:
7742:
7739:
7737:
7731:
7729:
7726:
7724:
7721:
7719:
7716:
7714:
7711:
7710:
7708:
7704:
7701:
7698:
7693:
7683:
7680:
7678:
7675:
7673:
7670:
7667:
7666:
7661:
7658:
7656:
7655:Ruthenium red
7653:
7651:
7648:
7646:
7643:
7641:
7638:
7636:
7635:Niflumic acid
7633:
7630:
7626:
7623:
7621:
7618:
7616:
7613:
7611:
7608:
7606:
7603:
7601:
7598:
7596:
7593:
7591:
7588:
7586:
7583:
7581:
7578:
7577:
7575:
7571:
7565:
7562:
7560:
7557:
7555:; indirectly)
7554:
7550:
7546:
7542:
7538:
7535:
7534:
7529:
7525:
7522:
7519:
7518:
7513:
7510:
7508:
7505:
7503:
7500:
7497:
7493:
7490:
7488:
7485:
7483:
7480:
7478:
7475:
7473:
7470:
7468:
7465:
7463:
7462:Frescolat MGA
7460:
7457:
7453:
7450:
7448:
7445:
7443:
7440:
7438:
7435:
7433:
7430:
7427:
7424:
7422:
7419:
7417:
7414:
7413:
7411:
7407:
7404:
7401:
7396:
7386:
7383:
7381:
7378:
7376:
7373:
7371:
7368:
7366:
7365:Niflumic acid
7363:
7361:
7358:
7356:
7353:
7351:
7348:
7346:
7343:
7341:
7338:
7336:
7333:
7331:
7328:
7327:
7325:
7321:
7315:
7312:
7309:
7305:
7302:
7300:
7297:
7295:
7292:
7289:
7285:
7282:
7281:
7279:
7275:
7272:
7269:
7264:
7254:
7253:Ruthenium red
7251:
7249:
7246:
7243:
7239:
7236:
7234:
7231:
7228:
7224:
7221:
7219:
7216:
7214:
7211:
7210:
7208:
7204:
7198:
7195:
7192:
7188:
7185:
7182:
7178:
7175:
7173:
7170:
7167:
7163:
7160:
7158:
7155:
7152:
7148:
7144:
7140:
7137:
7134:
7130:
7127:
7125:
7122:
7120:
7117:
7115:
7112:
7109:
7105:
7102:
7099:
7095:
7092:
7089:
7085:
7082:
7080:
7077:
7074:
7070:
7067:
7065:
7064:Methylglyoxal
7062:
7059:
7055:
7051:
7048:
7045:
7044:
7039:
7035:
7032:
7030:
7027:
7025:
7022:
7020:
7017:
7015:
7012:
7010:
7007:
7005:
7002:
6999:
6995:
6992:
6990:
6987:
6985:
6982:
6979:
6978:
6973:
6970:
6968:
6965:
6962:
6958:
6955:
6952:
6948:
6945:
6942:
6938:
6937:Cuminaldehyde
6935:
6933:
6930:
6928:
6925:
6922:
6918:
6915:
6912:
6908:
6905:
6902:
6898:
6895:
6892:
6888:
6885:
6883:
6880:
6878:
6875:
6873:
6870:
6867:
6863:
6859:
6855:
6851:
6848:
6845:
6841:
6838:
6836:
6833:
6830:
6826:
6822:
6818:
6815:
6813:
6810:
6808:
6805:
6803:
6800:
6798:
6795:
6793:
6790:
6789:
6787:
6783:
6780:
6777:
6772:
6768:
6765:
6755:
6750:
6748:
6743:
6741:
6736:
6735:
6732:
6722:
6721:
6714:
6700:
6697:
6695:
6694:Voltage-gated
6692:
6690:
6687:
6685:
6682:
6681:
6679:
6677:
6673:
6669:
6665:
6660:
6656:
6642:
6639:
6633:
6630:
6628:
6625:
6623:
6620:
6619:
6617:
6613:
6610:
6608:
6605:
6603:
6600:
6599:
6597:
6593:
6590:
6588:
6585:
6583:
6580:
6578:
6575:
6573:
6570:
6568:
6565:
6563:
6560:
6559:
6557:
6553:
6550:
6548:
6545:
6543:
6540:
6538:
6535:
6533:
6530:
6528:
6525:
6523:
6520:
6519:
6517:
6516:
6515:
6512:
6511:
6509:
6507:
6504:
6502:
6497:
6491:
6488:
6484:
6481:
6479:
6476:
6474:
6471:
6470:
6469:
6466:
6462:
6459:
6457:
6454:
6452:
6449:
6447:
6444:
6442:
6439:
6437:
6434:
6432:
6429:
6427:
6424:
6422:
6419:
6417:
6414:
6413:
6412:
6409:
6408:
6406:
6404:
6401:
6399:
6395:
6386:
6378:
6375:
6373:
6370:
6368:
6365:
6363:
6360:
6358:
6355:
6353:
6350:
6349:
6348:
6345:
6341:
6338:
6336:
6333:
6332:
6331:
6328:
6326:
6323:
6319:
6316:
6314:
6311:
6309:
6306:
6305:
6304:
6301:
6297:
6294:
6292:
6289:
6287:
6284:
6282:
6279:
6277:
6274:
6272:
6269:
6267:
6264:
6262:
6259:
6258:
6257:
6254:
6250:
6247:
6245:
6242:
6240:
6237:
6235:
6232:
6230:
6227:
6225:
6222:
6220:
6217:
6215:
6212:
6211:
6210:
6207:
6204:
6200:
6197:
6196:
6194:
6192:
6189:
6187:
6182:
6174:
6171:
6169:
6166:
6164:
6161:
6159:
6156:
6154:
6151:
6150:
6149:
6148:
6144:
6140:
6137:
6135:
6132:
6130:
6127:
6126:
6125:
6122:
6118:
6115:
6113:
6110:
6108:
6105:
6103:
6100:
6099:
6098:
6095:
6094:
6092:
6090:
6087:
6085:
6080:
6074:
6071:
6070:
6068:
6066:
6063:
6061:
6056:
6048:
6045:
6043:
6040:
6039:
6038:
6035:
6031:
6028:
6026:
6023:
6021:
6018:
6016:
6013:
6011:
6008:
6006:
6003:
6001:
5998:
5997:
5996:
5993:
5989:
5986:
5984:
5981:
5979:
5976:
5974:
5971:
5969:
5966:
5964:
5961:
5959:
5956:
5954:
5951:
5949:
5946:
5945:
5944:
5941:
5939:
5936:
5930:
5927:
5925:
5922:
5920:
5917:
5915:
5912:
5911:
5910:
5907:
5903:
5900:
5898:
5895:
5894:
5893:
5890:
5886:
5883:
5882:
5881:
5878:
5877:
5876:
5873:
5872:
5870:
5868:
5865:
5863:
5858:
5854:
5850:
5849:Miscellaneous
5845:
5841:
5827:
5826:Shaker (gene)
5824:
5820:
5817:
5815:
5812:
5810:
5807:
5806:
5805:
5802:
5800:
5799:minK/ISK-like
5797:
5795:
5792:
5788:
5785:
5783:
5780:
5778:
5775:
5773:
5770:
5769:
5768:
5765:
5761:
5758:
5756:
5753:
5751:
5748:
5747:
5746:
5739:
5738:
5733:
5730:
5728:
5725:
5723:
5720:
5719:
5718:
5714:
5711:
5709:
5706:
5704:
5701:
5700:
5699:
5695:
5692:
5690:
5687:
5686:
5685:
5681:
5678:
5676:
5673:
5671:
5668:
5667:
5666:
5662:
5659:
5657:
5654:
5653:
5652:
5648:
5645:
5643:
5640:
5638:
5635:
5633:
5630:
5628:
5625:
5624:
5623:
5616:
5615:
5610:
5607:
5605:
5602:
5600:
5597:
5595:
5592:
5591:
5590:
5586:
5583:
5582:
5581:
5577:
5574:
5572:
5569:
5567:
5564:
5563:
5562:
5558:
5555:
5553:
5550:
5548:
5545:
5543:
5540:
5539:
5538:
5534:
5531:
5529:
5526:
5525:
5524:
5520:
5517:
5515:
5512:
5510:
5507:
5505:
5502:
5500:
5497:
5495:
5492:
5490:
5487:
5485:
5482:
5481:
5480:
5473:
5472:
5470:
5468:
5467:Voltage-gated
5464:
5456:
5453:
5451:
5448:
5446:
5443:
5441:
5438:
5436:
5433:
5431:
5428:
5426:
5423:
5421:
5418:
5416:
5413:
5411:
5408:
5406:
5403:
5401:
5398:
5396:
5393:
5391:
5388:
5386:
5383:
5382:
5381:
5378:
5377:
5375:
5373:
5369:
5361:
5358:
5356:
5353:
5351:
5348:
5346:
5343:
5341:
5338:
5336:
5333:
5332:
5331:
5325:
5321:
5318:
5316:
5313:
5311:
5308:
5306:
5303:
5302:
5301:
5294:
5291:
5287:
5284:
5282:
5279:
5277:
5274:
5272:
5269:
5267:
5264:
5262:
5259:
5258:
5257:
5251:
5249:
5243:
5242:
5240:
5238:
5234:
5226:
5223:
5221:
5218:
5216:
5213:
5211:
5208:
5206:
5203:
5201:
5198:
5196:
5193:
5191:
5188:
5187:
5186:
5180:
5176:
5173:
5172:
5170:
5166:
5163:
5161:
5158:
5156:
5153:
5152:
5151:
5148:
5144:
5141:
5139:
5136:
5134:
5131:
5129:
5126:
5124:
5121:
5120:
5119:
5116:
5115:
5113:
5111:
5107:
5103:
5099:
5096:
5091:
5087:
5071:
5068:
5066:
5063:
5061:
5058:
5056:
5053:
5052:
5051:
5044:
5040:
5037:
5035:
5032:
5030:
5027:
5025:
5022:
5020:
5017:
5015:
5012:
5010:
5007:
5005:
5002:
5000:
4997:
4995:
4992:
4991:
4990:
4983:
4982:
4980:
4978:
4977:Voltage-gated
4974:
4966:
4963:
4961:
4958:
4956:
4953:
4951:
4948:
4947:
4946:
4943:
4942:
4940:
4937:
4933:
4925:
4922:
4920:
4917:
4915:
4912:
4910:
4907:
4906:
4905:
4902:
4901:
4899:
4895:
4891:
4887:
4884:
4879:
4875:
4859:
4856:
4854:
4851:
4850:
4849:
4846:
4842:
4839:
4837:
4834:
4832:
4829:
4827:
4824:
4823:
4822:
4819:
4818:
4813:
4810:
4808:
4805:
4803:
4800:
4798:
4795:
4794:
4793:
4790:
4786:
4783:
4781:
4778:
4776:
4773:
4771:
4768:
4767:
4766:
4763:
4759:
4756:
4754:
4751:
4750:
4749:
4742:
4741:
4736:
4733:
4731:
4728:
4726:
4723:
4722:
4721:
4713:
4710:
4708:
4700:
4697:
4695:
4687:
4684:
4680:
4677:
4676:
4675:
4667:
4664:
4662:
4654:
4651:
4647:
4644:
4642:
4639:
4637:
4634:
4632:
4629:
4628:
4627:
4619:
4616:
4615:
4613:
4611:
4610:Voltage-gated
4607:
4599:
4596:
4594:
4591:
4589:
4586:
4585:
4584:
4581:
4577:
4574:
4572:
4569:
4567:
4564:
4563:
4562:
4559:
4558:
4556:
4552:
4548:
4544:
4541:
4536:
4532:
4527:
4523:
4519:
4512:
4507:
4505:
4500:
4498:
4493:
4492:
4489:
4482:
4478:
4475:
4474:
4461:
4457:
4452:
4447:
4443:
4439:
4436:(3): 200–15.
4435:
4431:
4427:
4420:
4412:
4408:
4403:
4398:
4394:
4390:
4386:
4382:
4378:
4371:
4363:
4359:
4354:
4349:
4344:
4339:
4335:
4331:
4327:
4320:
4312:
4308:
4303:
4298:
4294:
4290:
4286:
4282:
4278:
4271:
4263:
4259:
4255:
4251:
4247:
4243:
4239:
4235:
4228:
4220:
4216:
4212:
4208:
4201:
4192:
4187:
4183:
4176:
4168:
4164:
4159:
4154:
4150:
4146:
4142:
4135:
4133:
4131:
4122:
4118:
4113:
4108:
4104:
4100:
4096:
4092:
4088:
4081:
4079:
4070:
4066:
4062:
4058:
4054:
4050:
4046:
4042:
4034:
4026:
4022:
4018:
4014:
4011:(3): 248–53.
4010:
4006:
3999:
3991:
3985:
3977:
3973:
3969:
3965:
3962:(4): 383–96.
3961:
3957:
3950:
3942:
3938:
3933:
3928:
3924:
3920:
3916:
3909:
3907:
3905:
3896:
3892:
3887:
3882:
3877:
3872:
3868:
3864:
3863:FASEB Journal
3860:
3853:
3845:
3841:
3836:
3831:
3826:
3821:
3817:
3813:
3809:
3805:
3801:
3794:
3786:
3782:
3778:
3774:
3770:
3766:
3758:
3750:
3746:
3741:
3736:
3732:
3728:
3723:
3718:
3714:
3710:
3706:
3699:
3691:
3687:
3683:
3679:
3675:
3671:
3667:
3663:
3659:
3655:
3648:
3646:
3637:
3633:
3628:
3623:
3618:
3613:
3609:
3605:
3601:
3597:
3593:
3586:
3578:
3574:
3569:
3564:
3560:
3556:
3552:
3548:
3544:
3537:
3529:
3525:
3520:
3515:
3511:
3507:
3503:
3499:
3495:
3488:
3480:
3476:
3471:
3466:
3462:
3458:
3455:(4): 269–77.
3454:
3450:
3446:
3439:
3431:
3425:
3421:
3417:
3413:
3406:
3398:
3394:
3389:
3384:
3380:
3376:
3372:
3368:
3364:
3360:
3356:
3349:
3341:
3337:
3332:
3327:
3323:
3319:
3315:
3311:
3307:
3300:
3292:
3288:
3283:
3278:
3274:
3270:
3267:(5): 671–80.
3266:
3262:
3258:
3251:
3243:
3239:
3234:
3229:
3225:
3221:
3217:
3213:
3209:
3202:
3194:
3190:
3185:
3180:
3176:
3172:
3169:(6): 360–70.
3168:
3164:
3160:
3153:
3145:
3141:
3136:
3131:
3126:
3121:
3117:
3113:
3109:
3105:
3101:
3094:
3086:
3082:
3078:
3074:
3069:
3064:
3060:
3056:
3052:
3048:
3044:
3040:
3036:
3029:
3021:
3017:
3012:
3007:
3003:
2999:
2995:
2991:
2987:
2983:
2979:
2972:
2964:
2960:
2955:
2950:
2946:
2942:
2937:
2932:
2928:
2924:
2920:
2916:
2912:
2905:
2897:
2893:
2888:
2883:
2879:
2875:
2871:
2867:
2863:
2859:
2855:
2848:
2840:
2836:
2831:
2826:
2821:
2816:
2812:
2808:
2804:
2797:
2789:
2785:
2781:
2777:
2773:
2769:
2765:
2761:
2754:
2746:
2742:
2737:
2732:
2729:(6): 1123–5.
2728:
2724:
2720:
2713:
2705:
2701:
2696:
2691:
2686:
2681:
2677:
2673:
2669:
2665:
2661:
2654:
2646:
2642:
2638:
2634:
2630:
2626:
2622:
2618:
2611:
2604:
2596:
2592:
2588:
2584:
2580:
2576:
2572:
2568:
2564:
2557:
2549:
2545:
2540:
2535:
2531:
2527:
2523:
2519:
2515:
2508:
2500:
2496:
2492:
2488:
2484:
2480:
2472:
2470:
2461:
2457:
2453:
2449:
2444:
2439:
2435:
2431:
2427:
2423:
2419:
2412:
2410:
2401:
2397:
2392:
2387:
2383:
2379:
2375:
2371:
2367:
2360:
2358:
2349:
2345:
2340:
2335:
2330:
2325:
2321:
2317:
2316:FASEB Journal
2313:
2306:
2298:
2294:
2290:
2286:
2282:
2278:
2274:
2270:
2263:
2255:
2251:
2247:
2243:
2239:
2235:
2228:
2220:
2214:
2206:
2202:
2198:
2192:
2188:
2184:
2180:
2173:
2165:
2161:
2157:
2153:
2149:
2145:
2141:
2137:
2130:
2123:
2121:
2112:
2108:
2103:
2098:
2094:
2090:
2086:
2079:
2077:
2068:
2064:
2060:
2056:
2052:
2048:
2045:(4): 427–50.
2044:
2040:
2033:
2031:
2022:
2018:
2013:
2008:
2004:
2000:
1996:
1989:
1981:
1977:
1971:
1963:
1959:
1953:
1946:
1942:
1937:
1935:
1933:
1925:
1921:
1916:
1914:
1912:
1907:
1896:
1893:
1890:
1887:
1884:
1882:
1879:
1876:
1873:
1872:
1864:
1861:
1860:
1852:
1849:
1847:
1844:
1842:
1839:
1837:
1834:
1832:
1829:
1827:
1824:
1822:
1819:
1817:
1814:
1812:
1809:
1807:
1804:
1802:
1799:
1797:
1794:
1792:
1789:
1787:
1784:
1782:
1780:
1776:
1772:
1768:
1764:
1759:
1756:
1753:
1751:
1748:
1746:
1743:
1741:
1738:
1736:
1733:
1731:
1728:
1726:
1723:
1721:
1718:
1716:
1713:
1711:
1708:
1706:
1703:
1702:
1691:
1689:
1688:down-regulate
1685:
1681:
1677:
1673:
1669:
1665:
1661:
1657:
1653:
1649:
1645:
1640:
1631:
1629:
1628:
1623:
1618:
1616:
1615:ACE inhibitor
1612:
1608:
1604:
1601:
1597:
1592:
1590:
1587:enzymes (see
1586:
1582:
1578:
1574:
1571:, 5,6-epoxy-8
1570:
1566:
1562:
1558:
1554:
1550:
1546:
1542:
1538:
1534:
1530:
1526:
1522:
1518:
1514:
1510:
1506:
1502:
1498:
1494:
1490:
1486:
1482:
1478:
1473:
1471:
1467:
1463:
1459:
1455:
1451:
1447:
1435:
1431:
1430:lipophilicity
1427:
1423:
1419:
1415:
1407:
1403:
1399:
1395:
1391:
1387:
1386:electrophilic
1383:
1379:
1374:
1372:
1368:
1364:
1361:
1356:
1348:
1344:
1342:
1338:
1333:
1331:
1327:
1322:
1318:
1312:
1303:
1301:
1296:
1292:
1291:electrophiles
1288:
1284:
1280:
1276:
1272:
1268:
1264:
1254:
1252:
1248:
1243:
1240:
1238:
1234:
1230:
1226:
1222:
1218:
1214:
1210:
1206:
1202:
1198:
1194:
1190:
1186:
1182:
1178:
1174:
1169:
1166:
1162:
1152:
1149:
1144:
1142:
1138:
1134:
1130:
1126:
1122:
1118:
1114:
1102:
1097:
1093:
1089:
1086:
1082:
1075:
1073:
1070:
1066:
1062:
1058:
1055:
1051:
1047:
1040:
1038:
1034:
1028:
1024:
1021:
1015:
1013:
1007:
1003:
1000:
996:
989:
987:
983:
977:
973:
970:
964:
962:
956:
952:
949:
947:RefSeq (mRNA)
945:
938:
937:
932:
928:
925:
919:
918:
913:
909:
906:
904:
900:
893:
892:
887:
883:
880:
874:
873:
868:
864:
861:
859:
855:
848:
847:
842:
838:
835:
829:
828:
823:
819:
816:
814:
810:
807:
804:
802:
799:
795:
792:
788:
784:
777:
773:
768:
762:
759:
757:
754:
752:
749:
747:
744:
742:
739:
737:
736:thermoception
734:
732:
729:
727:
724:
722:
719:
717:
714:
712:
709:
707:
704:
702:
699:
697:
694:
692:
691:ion transport
689:
687:
684:
682:
679:
677:
674:
673:
671:
668:
667:
661:
658:
656:
653:
651:
648:
646:
643:
641:
638:
637:
635:
632:
631:
625:
622:
620:
617:
615:
612:
610:
607:
605:
602:
600:
597:
596:
594:
591:
590:
587:
586:Gene ontology
583:
579:
567:
562:
558:
551:
546:
543:
541:
537:
529:
524:
513:
509:
505:
501:
497:
493:
489:
485:
481:
477:
476:
473:
469:
464:
461:
451:
447:
443:
439:
435:
431:
427:
423:
419:
415:
414:
411:
407:
402:
399:
398:
395:
393:
389:
387:
386:
382:
381:
378:
376:
372:
368:
364:
360:
352:
347:
343:
339:
334:
324:
320:
313:
306:
300:
293:
285:
281:
277:
272:
268:
263:
259:
251:
246:
242:
238:
233:
223:
219:
212:
205:
199:
192:
188:
182:
178:
174:
169:
165:
160:
156:
152:
148:
144:
140:
136:
132:
128:
124:
120:
116:
108:
103:
96:
91:
86:
75:
73:
67:
62:
59:
58:
54:
51:
44:
40:
35:
31:
27:
22:
19:
8612:Ion channels
8574:
8573:
8414:Cannabigerol
8385:
8338:
8280:
8268:
8230:black pepper
8190:chili pepper
8123:chili pepper
8113:chili pepper
8104:Hepoxilin B3
8099:Hepoxilin A3
8070:
8042:chili pepper
8000:chili pepper
7941:
7804:
7663:
7590:Clotrimazole
7531:
7515:
7467:Frescolat ML
7375:Progesterone
7284:Adhyperforin
7197:WIN 55,212-2
7190:
7041:
7009:Hepoxilin B3
7004:Hepoxilin A3
6975:
6907:Cannabigerol
6717:
6684:Ligand-gated
6675:
6663:
6506:Gap junction
6499:
6388:
6184:
6145:
6123:
6096:
6082:
6058:
6036:
5994:
5942:
5908:
5891:
5879:
5860:
5848:
5803:
5766:
5740:
5617:
5474:
5379:
5326:
5296:
5252:
5181:
5094:
5045:
4984:
4882:
4791:
4764:
4743:
4715:
4702:
4689:
4669:
4656:
4621:
4554:Ligand-gated
4539:
4522:ion channels
4433:
4429:
4419:
4384:
4380:
4370:
4333:
4329:
4319:
4284:
4280:
4270:
4237:
4233:
4227:
4210:
4206:
4200:
4181:
4175:
4148:
4144:
4094:
4090:
4044:
4040:
4033:
4008:
4004:
3998:
3984:
3959:
3955:
3949:
3922:
3918:
3866:
3862:
3852:
3807:
3803:
3793:
3768:
3764:
3757:
3712:
3708:
3698:
3657:
3653:
3599:
3595:
3585:
3553:(4): 333–9.
3550:
3546:
3536:
3501:
3497:
3487:
3452:
3448:
3438:
3411:
3405:
3362:
3358:
3348:
3313:
3309:
3299:
3264:
3260:
3250:
3215:
3211:
3201:
3166:
3162:
3152:
3107:
3103:
3093:
3042:
3038:
3028:
2985:
2981:
2971:
2918:
2914:
2904:
2861:
2857:
2847:
2810:
2806:
2796:
2763:
2759:
2753:
2726:
2722:
2712:
2667:
2663:
2653:
2620:
2616:
2603:
2570:
2566:
2556:
2521:
2517:
2507:
2482:
2478:
2425:
2421:
2373:
2369:
2319:
2315:
2305:
2275:(2): 150–6.
2272:
2268:
2262:
2237:
2233:
2227:
2213:
2178:
2172:
2139:
2135:
2095:(7): 771–7.
2092:
2088:
2042:
2038:
2002:
1998:
1988:
1979:
1970:
1961:
1952:
1831:Cannabigerol
1778:
1774:
1770:
1766:
1762:
1641:
1637:
1625:
1619:
1593:
1580:
1576:
1572:
1564:
1555:and tactile
1553:hyperalgesia
1544:
1540:
1536:
1532:
1528:
1524:
1520:
1516:
1511:-HpETE; see
1508:
1504:
1500:
1496:
1492:
1488:
1474:
1375:
1357:
1354:
1345:
1334:
1313:
1309:
1267:homotetramer
1260:
1244:
1241:
1170:
1158:
1146:TRPA1 is an
1145:
1136:
1132:
1124:
1120:
1116:
1112:
1111:
1037:NP_001335217
1030:
1009:
986:NM_001348288
979:
958:
934:
915:
889:
870:
844:
825:
805:
800:
390:
383:
110:External IDs
69:
18:
8549:Tivanisiran
8454:Capsazepine
8366:Zucapsaicin
8234:long pepper
8200:Pacific yew
8089:GSK1016790A
7976:Cannabidiol
7962:camphorweed
7650:RQ-00203078
7645:PF-05105679
7585:Capsazepine
7350:GSK2293017A
7314:Substance P
7299:GSK1702934A
7248:PF-04745637
7187:Umbellulone
7108:Pacific yew
7094:Oleocanthal
7073:wintergreen
7034:Ligustilide
6897:Cannabidiol
6862:horseradish
6689:Light-gated
5171:IK channel
4240:(1): 3–22.
4207:MedChemComm
4047:(1): 10–7.
3925:(1): 50–5.
2443:10261/16906
1869:Antagonists
1725:Cannabidiol
1605:to trigger
1477:eicosanoids
1398:ion channel
1367:oleocanthal
1337:paracetamol
1221:nociception
1209:chemosensor
1148:ion channel
349:14,989,086
336:14,942,872
328:1|1 A3
248:72,075,584
235:72,019,917
88:Identifiers
8596:Categories
8444:Cannabinol
8344:pooissonii
8335:Tinyatoxin
8286:pooissonii
8250:Probenecid
8240:Polygodial
8196:Paclitaxel
8180:PAVA spray
8067:Evodiamine
8018:pepperwort
7933:Anandamide
7900:α-Sanshool
7848:Activators
7801:Triptolide
7794:Activators
7706:Activators
7682:TRPM4-IN-5
7600:Elismetrep
7528:stevioside
7456:eucalyptus
7452:Eucalyptol
7416:ADP-ribose
7409:Activators
7345:GSK417651A
7304:Hyperforin
7277:Activators
7157:Tear gases
7129:Polygodial
7119:PF-4840154
7104:Paclitaxel
6972:Dicentrine
6882:Bradykinin
6817:α-Sanshool
6785:Activators
6767:modulators
5892:Bestrophin
5150:SK channel
5118:BK channel
4792:γ-subunits
4765:β-subunits
4748:δ-subunits
4336:: 830930.
3316:(2): 551.
3163:Physiology
1947:, May 2017
1926:, May 2017
1902:References
1897:ALGX-2542
1806:Anandamide
1796:PF-4840154
1755:Hepoxilins
1745:Polygodial
1668:astrocytes
1446:PF-4840154
1434:PF-4840154
1424:(0.9 nM),
1392:bond with
1247:loreal pit
1205:PF-4840154
1197:tear gases
394:(ortholog)
131:HomoloGene
8575:See also:
8559:TRPV3-74a
8544:SB-705498
8539:SB-366791
8489:Lanthanum
8484:HC-067047
8404:Asivatrep
8265:Rutamarin
8129:Incensole
8079:Gingerols
8048:Estradiol
8024:, others)
8006:Carvacrol
7996:Capsaicin
7890:13-oxoODE
7880:12S-HpETE
7860:5',6'-EET
7660:Rutamarin
7559:Thio-BCTC
7512:Rutamarin
7442:Coolact P
7233:HC-030031
7098:olive oil
6994:Gingerols
6807:12S-HpETE
6720:disorders
6718:see also
6501:Cytoplasm
6411:Aquaporin
5880:Anoctamin
5703:11.1/hERG
4167:218776153
4151:(S1): 1.
3731:1083-351X
3365:: 12840.
3085:220407248
2945:1932-6203
2766:: 39–46.
1894:ALGX-2561
1891:ALGX-2563
1888:ALGX-2541
1885:ALGX-2513
1874:HC-030031
1757:A3 and B3
1664:microglia
1644:resolvins
1557:allodynia
1466:HC-030031
1420:(30 nM),
1371:olive oil
1365:compound
1360:olive oil
1341:capsaicin
1261:In 2016,
1257:Structure
1033:NP_808449
1012:NP_015628
982:NM_177781
961:NM_007332
791:Orthologs
139:GeneCards
8509:NGD-8243
8494:Mavatrep
8479:GRC-6211
8448:cannabis
8438:cannabis
8428:cannabis
8418:cannabis
8399:AMG-9810
8375:Blockers
8356:Vanillin
8351:Tramadol
8315:cannabis
8293:Shogaols
8226:Piperine
7990:cannabis
7980:cannabis
7958:rosemary
7875:12S-HETE
7870:9-oxoODE
7817:Blockers
7767:PI(4,5)P
7755:Blockers
7733:PI(3,5)P
7640:Ononetin
7625:Nicotine
7573:Blockers
7549:fructose
7541:tastants
7487:Linalool
7472:Geraniol
7432:CIM-0216
7323:Blockers
7238:Nicotine
7213:A-967079
7206:Blockers
7166:cannabis
7139:Shogaols
7084:Nicotine
7050:Linalool
6989:Formalin
6951:turmeric
6947:Curcumin
6921:cinnamon
6911:cannabis
6901:cannabis
6891:cannabis
6877:ASP-7663
6835:Acrolein
6514:Connexin
5794:minK/ISK
4460:25857211
4411:21963090
4362:26339646
4311:25359497
4262:10160642
4254:25052386
4121:31447178
4069:22282464
4061:21052031
4025:21727026
3976:25240838
3941:24102997
3895:23382512
3844:22493235
3785:20806939
3749:20826794
3682:17237762
3636:17164327
3577:19273462
3528:21248124
3479:20601631
3397:27628562
3340:22109525
3291:20547126
3242:18568077
3193:19074743
3144:18988737
3077:32641835
3020:25855297
2963:22163322
2915:PLOS ONE
2896:20228791
2839:18086308
2788:25946719
2780:17588549
2745:16564004
2704:17686976
2645:23263861
2637:28614189
2595:44150443
2587:29847470
2548:18234879
2499:21741838
2452:19749751
2400:18398506
2348:19036859
2297:18501939
2254:20356305
2205:17217068
2164:10418526
2156:25792226
2111:26015312
2067:17936350
2059:16382100
2021:10066796
1943:–
1922:–
1881:A-967079
1877:GRC17536
1750:Propofol
1735:Gingerol
1720:ASP-7663
1699:Agonists
1462:A-967079
1458:ASP-7663
1402:propofol
1394:cysteine
1390:covalent
1363:phenolic
1326:mutation
1321:Colombia
1275:calcium)
1217:C-fibers
1201:nicotine
1193:acrolein
1181:formalin
1155:Function
1127:, is a
1085:Wikidata
770:Sources:
650:membrane
506:epiblast
8529:RN-9893
8524:RN-1734
8394:AMG-517
8360:vanilla
8329:oregano
8301:Sichuan
8279:(RTX) (
8255:Protons
8218:(e.g.,
8151:Menthol
8133:incense
8053:Eugenol
8010:oregano
7950:Camphor
7918:Allicin
7908:Sichuan
7895:20-HETE
7885:13-HODE
7728:ML2-SA1
7629:tobacco
7580:AMG-333
7553:sucrose
7545:glucose
7543:(e.g.,
7526:(e.g.,
7492:Menthol
7426:Calcium
7242:tobacco
7218:AM-0902
7147:Sichuan
7088:tobacco
6977:Lindera
6854:mustard
6840:Allicin
6825:Sichuan
6802:4,5-EET
6764:channel
6641:Innexin
6398:solutes
4451:4515371
4402:3200462
4353:4538417
4302:4315926
4112:6731142
3886:3633813
3835:3340022
3812:Bibcode
3740:2966094
3690:4344572
3662:Bibcode
3627:1748265
3604:Bibcode
3568:4357805
3519:3073417
3470:3136963
3388:5027619
3367:Bibcode
3318:Bibcode
3282:4769261
3233:2430498
3184:2735846
3135:2582301
3112:Bibcode
3068:7483980
3047:Bibcode
3011:4409540
2990:Bibcode
2954:3233596
2923:Bibcode
2887:2855400
2866:Bibcode
2830:2222611
2695:1941642
2672:Bibcode
2539:6671416
2460:1670299
2391:2289796
2339:2660642
2277:Bibcode
1945:Ensembl
1924:Ensembl
1710:Allicin
1648:maresin
1569:epoxide
1470:AM-0902
1414:CR 'gas
1382:menthol
1273:(e.g.,
1129:protein
903:UniProt
858:Ensembl
797:Species
776:QuickGO
510:jejunum
369:pattern
227:8q21.11
127:3522699
95:Aliases
8469:DHEA-S
8321:Thymol
8297:ginger
8220:4α-PDD
8083:ginger
7922:garlic
7904:ginger
7865:9-HODE
7762:ML-SI3
7723:ML-SA1
7718:MK6-83
7539:Sweet
7502:PMD 38
7482:Icilin
7335:DHEA-S
7227:celery
7143:ginger
7038:celery
7029:JT-010
7019:Icilin
6998:ginger
6961:celery
6866:wasabi
6858:radish
6844:garlic
6821:ginger
4938:-gated
4936:Proton
4712:T-type
4699:R-type
4686:Q-type
4666:P-type
4653:N-type
4618:L-type
4483:(MeSH)
4458:
4448:
4409:
4399:
4360:
4350:
4309:
4299:
4260:
4252:
4165:
4119:
4109:
4067:
4059:
4023:
3974:
3939:
3893:
3883:
3842:
3832:
3783:
3747:
3737:
3729:
3688:
3680:
3654:Nature
3634:
3624:
3575:
3565:
3526:
3516:
3477:
3467:
3426:
3395:
3385:
3338:
3289:
3279:
3261:Neuron
3240:
3230:
3191:
3181:
3142:
3132:
3083:
3075:
3065:
3039:Nature
3018:
3008:
2982:Nature
2961:
2951:
2943:
2894:
2884:
2858:Nature
2837:
2827:
2786:
2778:
2743:
2702:
2692:
2643:
2635:
2593:
2585:
2546:
2536:
2497:
2458:
2450:
2398:
2388:
2346:
2336:
2295:
2252:
2203:
2193:
2162:
2154:
2109:
2065:
2057:
2019:
1740:Icilin
1682:, and
1672:CMKLR1
1646:) and
1481:ALOX12
1454:JT-010
1378:thymol
1233:target
1225:humans
1195:, and
1071:search
1069:PubMed
936:Q8BLA8
917:O75762
846:277328
813:Entrez
540:BioGPS
502:embryo
494:embryo
490:zygote
432:rectum
416:oocyte
119:604775
8459:DCDPC
8325:thyme
8061:clove
8057:basil
8014:thyme
7928:AM404
7855:2-APB
7741:SF-22
7713:EVP21
7697:TRPML
7595:DCDPC
7564:WS-12
7330:DCDPC
7181:onion
7058:thyme
6980:spp.)
6941:cumin
6872:AM404
6552:GJA10
6403:Porin
6303:TRPML
6073:HVCN1
5767:KCNIP
5622:α7-12
4526:TC 1A
4258:S2CID
4163:S2CID
4065:S2CID
3686:S2CID
3081:S2CID
2784:S2CID
2641:S2CID
2613:(PDF)
2591:S2CID
2456:S2CID
2160:S2CID
2132:(PDF)
2063:S2CID
1676:GPR32
1611:TRPV1
1607:cough
1561:TRPV1
1406:TRPV1
1213:TRPV1
1137:Trpa1
1133:TRPA1
1123:, or
1121:TRPA1
806:Mouse
801:Human
772:Amigo
514:colon
448:gonad
392:Mouse
385:Human
332:Start
267:Mouse
231:Start
164:Human
143:TRPA1
102:TRPA1
24:TRPA1
8464:DHEA
8409:BCTC
8303:and
8260:RhTx
8155:mint
8143:Low
8094:Heat
8028:DHEA
7910:and
7839:TRPV
7785:TRPP
7746:SN-2
7677:TPPO
7496:mint
7437:Cold
7421:BCTC
7400:TRPM
7380:Pyr3
7268:TRPC
7149:and
6827:and
6776:TRPA
6632:GJD4
6627:GJD3
6622:GJD2
6612:GJC3
6607:GJC2
6602:GJC1
6592:GJB7
6587:GJB6
6582:GJB5
6577:GJB4
6572:GJB3
6567:GJB2
6562:GJB1
6547:GJA9
6542:GJA8
6537:GJA5
6532:GJA4
6527:GJA3
6522:GJA1
6347:TRPV
6330:TRPP
6325:TRPN
6256:TRPM
6209:TRPC
6199:TRPA
6037:CLNS
5995:CLIC
5943:CLCN
5938:CFTR
5885:ANO1
5804:MiRP
5732:12.3
5727:12.2
5722:12.1
5713:11.3
5708:11.2
5694:10.2
5689:10.1
5479:α1-6
5293:GIRK
4707:α2.3
4694:α2.1
4661:α2.2
4456:PMID
4407:PMID
4358:PMID
4334:2015
4307:PMID
4250:PMID
4117:PMID
4091:Cell
4057:PMID
4021:PMID
3972:PMID
3960:1851
3937:PMID
3891:PMID
3840:PMID
3781:PMID
3745:PMID
3727:ISSN
3678:PMID
3632:PMID
3573:PMID
3524:PMID
3475:PMID
3424:ISBN
3393:PMID
3336:PMID
3287:PMID
3238:PMID
3189:PMID
3140:PMID
3073:PMID
3016:PMID
2959:PMID
2941:ISSN
2892:PMID
2835:PMID
2776:PMID
2764:1160
2741:PMID
2723:Cell
2700:PMID
2633:PMID
2617:Pain
2583:PMID
2567:Pain
2544:PMID
2495:PMID
2448:PMID
2396:PMID
2344:PMID
2293:PMID
2250:PMID
2201:PMID
2191:ISBN
2152:PMID
2107:PMID
2055:PMID
2017:PMID
1863:WaTx
1680:FPR2
1487:, 12
1475:The
1468:and
1456:and
1380:and
1283:PIP2
1229:pain
1141:gene
827:8989
375:Bgee
323:Band
284:Chr.
222:Band
181:Chr.
135:7189
115:OMIM
72:3J9P
53:RCSB
50:PDBe
7530:) (
6762:TRP
6396:(+
6234:4AP
6147:HCN
5680:9.3
5675:9.2
5670:9.1
5661:8.2
5656:8.1
5647:7.5
5642:7.4
5637:7.3
5632:7.2
5627:7.1
5609:6.4
5604:6.3
5599:6.2
5594:6.1
5585:5.1
5576:4.3
5571:4.2
5566:4.1
5557:3.4
5552:3.3
5547:3.2
5542:3.1
5533:2.2
5528:2.1
5519:1.8
5514:1.7
5509:1.6
5504:1.5
5499:1.4
5494:1.3
5489:1.2
5484:1.1
5380:K2P
5360:7.1
5355:6.2
5350:6.1
5345:5.1
5340:4.2
5335:4.1
5320:3.4
5315:3.3
5310:3.2
5305:3.1
5286:2.6
5281:2.4
5276:2.3
5271:2.2
5266:2.1
5261:1.1
5247:ATP
5225:5.1
5220:4.2
5215:4.1
5210:3.1
5205:2.3
5200:2.2
5195:2.1
5190:1.1
5175:IK1
5165:SK3
5160:SK2
5155:SK1
5034:1.9
5029:1.8
5024:1.7
5019:1.6
5014:1.5
5009:1.4
5004:1.3
4999:1.2
4994:1.1
4883:Na:
4735:3.3
4730:3.2
4725:3.1
4679:2.1
4646:1.4
4641:1.3
4636:1.2
4631:1.1
4540:Ca:
4446:PMC
4438:doi
4397:PMC
4389:doi
4348:PMC
4338:doi
4297:PMC
4289:doi
4242:doi
4215:doi
4186:doi
4153:doi
4107:PMC
4099:doi
4095:178
4049:doi
4013:doi
3964:doi
3927:doi
3923:114
3881:PMC
3871:doi
3830:PMC
3820:doi
3808:109
3773:doi
3735:PMC
3717:doi
3713:285
3670:doi
3658:445
3622:PMC
3612:doi
3600:103
3563:PMC
3555:doi
3514:PMC
3506:doi
3465:PMC
3457:doi
3416:doi
3383:PMC
3375:doi
3326:doi
3277:PMC
3269:doi
3228:PMC
3220:doi
3216:118
3179:PMC
3171:doi
3130:PMC
3120:doi
3108:105
3063:PMC
3055:doi
3043:585
3006:PMC
2998:doi
2986:520
2949:PMC
2931:doi
2882:PMC
2874:doi
2862:464
2825:PMC
2815:doi
2768:doi
2731:doi
2727:124
2690:PMC
2680:doi
2668:104
2625:doi
2621:158
2575:doi
2571:159
2534:PMC
2526:doi
2487:doi
2438:hdl
2430:doi
2386:PMC
2378:doi
2374:118
2334:PMC
2324:doi
2285:doi
2273:231
2242:doi
2183:doi
2144:doi
2097:doi
2047:doi
2007:doi
2003:274
1777:,14
1773:,10
1666:or
1579:,14
1575:,11
1543:,14
1533:R/S
1527:,14
1517:R/S
1503:,14
1499:,10
1223:in
345:End
244:End
147:OMA
123:MGI
43:PDB
8598::
8580:•
8327:,
8299:,
8232:,
8145:pH
8059:,
8020:,
8016:,
8012:,
7968:,
7964:,
7960:,
7956:,
7906:,
7551:,
7547:,
7145:,
7056:,
7040:,
6864:,
6860:,
6856:,
6823:,
6618:D
6598:C
6558:B
6518:A
6400:):
6153:FC
6047:1B
6042:1A
6030:L1
5988:KB
5983:KA
5862:Cl
5455:18
5450:17
5445:16
5440:15
5435:13
5430:12
5425:10
5329:ir
5299:ir
5255:ir
5184:Ca
5143:β4
5138:β3
5133:β2
5128:β1
5123:α1
5095:K:
5046:Na
5039:7A
4985:Na
4812:γ4
4807:γ3
4802:γ2
4797:γ1
4785:β4
4780:β3
4775:β2
4770:β1
4716:Ca
4703:Ca
4690:Ca
4670:Ca
4657:Ca
4622:Ca
4520::
4454:.
4444:.
4434:27
4432:.
4428:.
4405:.
4395:.
4385:34
4383:.
4379:.
4356:.
4346:.
4332:.
4328:.
4305:.
4295:.
4283:.
4279:.
4256:.
4248:.
4238:39
4236:.
4209:.
4161:.
4149:34
4147:.
4143:.
4129:^
4115:.
4105:.
4093:.
4089:.
4077:^
4063:.
4055:.
4045:21
4043:.
4019:.
4009:11
4007:.
3970:.
3958:.
3935:.
3921:.
3917:.
3903:^
3889:.
3879:.
3867:27
3865:.
3861:.
3838:.
3828:.
3818:.
3806:.
3802:.
3779:.
3769:53
3767:.
3743:.
3733:.
3725:.
3711:.
3707:.
3684:.
3676:.
3668:.
3656:.
3644:^
3630:.
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