3817:
880:
833:
555:
462:
A phase II study showed that teplizumab could delay the development of diabetes in family members of type 1 diabetics showing signs of progression towards diabetes by about two years after a single treatment, renewing interest in its use as a preventive rather than therapeutic treatment in high-risk
402:
non-binding (FNB) properties. The mechanisms of action of teplizumab appear to involve weak agonistic activity on signaling via the T cell receptor-CD3 complex associated with the development of anergy, unresponsiveness, and/or apoptosis, particularly of unwanted activated Teff cells. In addition,
628:
434:
Teplizumab was developed at the
University of Chicago in partnership with Ortho Pharmaceuticals, and was then further developed at MacroGenics, Inc., including a collaboration with Eli Lilly to conduct the first Phase 3 clinical trial in early-onset
455:
patients. Immunomodulatory agents such as anti-CD3-antibodies may restore normal glucose control if provided in very early stages of the disease, such as stage 2 T1DM, when there are still enough beta cells to maintain euglycemia.
1046:"Teplizumab (anti-CD3 mAb) treatment preserves C-peptide responses in patients with new-onset type 1 diabetes in a randomized controlled trial: metabolic and immunologic features at baseline identify a subgroup of responders"
691:
Belghith M, Bluestone JA, Barriot S, MĂ©gret J, Bach JF, Chatenoud L (September 2003). "TGF-beta-dependent mechanisms mediate restoration of self-tolerance induced by antibodies to CD3 in overt autoimmune diabetes".
439:. After the initial Phase 3 trial conducted by Macrogenics failed to meet the primary endpoint, the drug was acquired by Provention Bio, which restarted development based on subset analysis of the original trials.
629:"Tzield (teplizumab-mzwv) approved by FDA as the first and only treatment indicated to delay the onset of Stage 3 type 1 diabetes (T1D) in adult and pediatric patients aged 8 years and older with stage 2 T1D"
480:
1095:"A single course of anti-CD3 monoclonal antibody hOKT3gamma1(Ala-Ala) results in improvement in C-peptide responses and clinical parameters for at least 2 years after onset of type 1 diabetes"
897:
Woodle ES, Bluestone JA, Zivin RA, Jolliffe LK, Auger J, Xu D, Thistlethwaite JR (June 1998). "Humanized, nonmitogenic OKT3 antibody, huOKT3 gamma(Ala-Ala): initial clinical experience".
810:
644:"An anti-murine CD3 monoclonal antibody with a low affinity for Fc gamma receptors suppresses transplantation responses while minimizing acute toxicity and immunogenicity"
1320:
459:
Teplizumab has been evaluated for treatment of renal allograft rejection, for induction therapy in islet transplant recipients, and for psoriatic arthritis.
140:
359:
573:
536:
1595:
1387:
3684:
3542:
2385:
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1093:
Herold KC, Gitelman SE, Masharani U, Hagopian W, Bisikirska B, Donaldson D, Rother K, Diamond B, Harlan DM, Bluestone JA (June 2005).
34:
3301:
505:
403:
regulatory cytokines are released and regulatory T cells are expanded that may lead to the reestablishment of immune tolerance
1306:
2329:
961:"Teplizumab for treatment of type 1 diabetes (Protégé study): 1-year results from a randomised, placebo-controlled trial"
865:
366:
115:
3244:
2614:
2378:
2346:
3653:
784:
170:
96:
3837:
2301:
1191:
Chatenoud L, Bluestone JA (August 2007). "CD3-specific antibodies: a portal to the treatment of autoimmunity".
426:
to delay the onset of stage 3 type 1 diabetes (T1D) people aged eight years of age and older with stage 2 T1D.
2450:
2311:
859:
816:
407:
256:
481:"Provention Bio Announces PRV-031 (Teplizumab) Granted PRIME Designation by the European Medicines Agency"
2559:
2371:
3807:
2429:
1044:
Herold KC, Gitelman SE, Ehlers MR, Gottlieb PA, Greenbaum CJ, Hagopian W, et al. (November 2013).
737:"TCR stimulation with modified anti-CD3 mAb expands CD8+ T cell population and induces CD8+CD25+ Tregs"
3107:
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411:
643:
44:
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126:
78:
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2713:
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1234:
Herold KC, Bundy BN, Long SA, Bluestone JA, DiMeglio LA, Dufort MJ, et al. (August 2019).
1298:
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1407:
1329:
571:
959:
Sherry N, Hagopian W, Ludvigsson J, Jain SM, Wahlen J, Ferry RJ, et al. (August 2011).
209:
1611:
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8:
2695:
574:"2. Classification and Diagnosis of Diabetes: Standards of Medical Care in Diabetes—2022"
384:
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642:
Alegre ML, Tso JY, Sattar HA, Smith J, Desalle F, Cole M, Bluestone JA (August 1995).
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Teplizumab was approved for medical use in the United States in
November 2022. The US
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Teplizumab has been used in clinical trials with the aim of protecting the remaining
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572:
American
Diabetes Association Professional Practice Committee (1 January 2022).
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that is the first approved treatment indicated to delay the onset of stage 3
1236:"An Anti-CD3 Antibody, Teplizumab, in Relatives at Risk for Type 1 Diabetes"
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Bisikirska B, Colgan J, Luban J, Bluestone JA, Herold KC (October 2005).
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811:"Advancing Health Through Innovation: New Drug Therapy Approvals 2022"
590:
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220:
110:
705:
3197:
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1941:
1027:"MacroGenics sells rights for two autoimmune disorder candidates"
883:
This article incorporates text from this source, which is in the
836:
This article incorporates text from this source, which is in the
558:
This article incorporates text from this source, which is in the
537:"FDA Approves First Drug That Can Delay Onset of Type 1 Diabetes"
61:
3512:
3343:
2281:
1328:
1092:
803:
734:
690:
3211:
3064:
53:
1043:
958:
932:
Brown WM (April 2006). "Anti-CD3 antibody MacroGenics Inc".
896:
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3131:
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2632:
2506:
276:
3040:
1233:
565:
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641:
1190:
500:
498:
3829:
1144:"Anti-CD3 mAbs for treatment of type 1 diabetes"
483:(Press release). Provention Bio. 24 October 2019
495:
208:
2379:
1314:
1141:
398:of this antibody has been engineered to have
1135:
1086:
925:
114:
890:
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2372:
1321:
1307:
1009:"MacroGenics, Lilly abandon diabetes drug"
1259:
1159:
1118:
1069:
984:
760:
659:
589:
264:
1148:Diabetes/Metabolism Research and Reviews
934:Current Opinion in Investigational Drugs
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529:
527:
228:
3830:
2367:
1302:
931:
741:The Journal of Clinical Investigation
524:
473:
179:
105:
2289:
1294:. U.S. National Library of Medicine.
868:from the original on 14 January 2024
152:
506:"Tzield- teplizumab-mzwv injection"
284:
13:
391:(T1D) in people with stage 2 T1D.
14:
3849:
1280:
1142:Kaufman A, Herold KC (May 2009).
543:(Press release). 17 November 2022
541:U.S. Food and Drug Administration
3815:
878:
831:
553:
318:
312:
91:teplizumab-mzwv, PRV-031, MGA031
1240:New England Journal of Medicine
1227:
1184:
1037:
1019:
1001:
952:
851:New Drug Therapy Approvals 2022
843:
785:"Drug Approval Package: Tzield"
417:
777:
728:
684:
635:
621:
330:
324:
306:
1:
977:10.1016/S0140-6736(11)60931-8
911:10.1016/S0041-1345(98)00278-4
466:
2451:dihydroorotate dehydrogenase
860:Food and Drug Administration
817:Food and Drug Administration
408:Food and Drug Administration
379:, sold under the brand name
7:
2430:purine synthesis inhibitors
1013:Washington Business Journal
899:Transplantation Proceedings
661:10.4049/jimmunol.155.3.1544
442:
410:(FDA) considers it to be a
10:
3854:
1193:Nature Reviews. Immunology
1111:10.2337/diabetes.54.6.1763
429:
383:, is a humanized anti-CD3
296:Chemical and physical data
3572:
3500:
3473:
3358:
3001:
2703:
2694:
2685:
2678:
2631:
2615:IL-1 receptor antagonists
2613:
2604:
2558:
2489:
2419:
2410:
2324:
2279:
2259:
2188:
2122:
2113:
2082:
1754:
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1620:
1349:
1340:
412:first-in-class medication
356:
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125:
95:
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60:
43:
33:
26:
3488:Anti-lymphocyte globulin
864:(Report). January 2024.
491:– via PR Newswire.
3483:Anti-thymocyte globulin
2395:Immunosuppressive drugs
1292:Drug Information Portal
3288:Interleukin-6 receptor
2714:Complement component 5
3838:Monoclonal antibodies
1408:Camidanlumab tesirine
1330:Monoclonal antibodies
1252:10.1056/nejmoa1902226
648:Journal of Immunology
2083:Chimeric + humanized
1612:Nivolumab/relatlimab
451:in newly diagnosed
385:monoclonal antibody
28:Monoclonal antibody
23:
16:Monoclonal antibody
3645:Diroximel fumarate
3318:IL-2 receptor/CD25
2746:Certolizumab pegol
2399:Immunosuppressants
2351:Never to phase III
1797:Certolizumab pegol
1764:Immunosuppressive:
1015:. 21 October 2010.
789:accessdata.fda.gov
512:. 17 November 2022
19:
3803:
3802:
3650:Efgartigimod alfa
3640:Dimethyl fumarate
3568:
3567:
3496:
3495:
3469:
3468:
2674:
2673:
2600:
2599:
2441:Mycophenolic acid
2361:
2360:
2320:
2319:
2275:
2274:
2109:
2108:
2064:Immune activation
1556:Immune activation
1358:Immunosuppression
1062:10.2337/db13-0345
1031:The Pharma Letter
821:. 10 January 2023
591:10.2337/dc22-S002
374:
373:
183:
108:
3845:
3820:
3819:
3818:
3811:
3446:Telimomab aritox
3349:Zolimomab aritox
3170:CD62L/L-selectin
2908:Immunoglobulin E
2701:
2700:
2692:
2691:
2683:
2682:
2611:
2610:
2417:
2416:
2388:
2381:
2374:
2365:
2364:
2287:
2286:
2120:
2119:
1678:Zolimomab aritox
1668:Telimomab aritox
1347:
1346:
1323:
1316:
1309:
1300:
1299:
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1161:10.1002/dmrr.933
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1016:
1005:
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988:
971:(9790): 487–97.
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791:. 5 January 2023
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753:10.1172/JCI23961
732:
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631:(Press release).
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3799:
3745:Rozanolixizumab
3630:Deucravacitinib
3564:
3492:
3465:
3354:
3003:
2997:
2705:
2670:
2627:
2606:
2596:
2554:
2494:
2485:
2421:Antimetabolites
2412:
2406:
2392:
2362:
2357:
2356:
2341:Clinical trials
2316:
2271:
2255:
2184:
2105:
2096:Rozanolixizumab
2084:
2078:
2070:
2059:
1872:Lulizumab pegol
1750:
1682:
1616:
1336:
1327:
1286:
1283:
1278:
1277:
1232:
1228:
1205:10.1038/nri2134
1189:
1185:
1140:
1136:
1091:
1087:
1056:(11): 3766–74.
1042:
1038:
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1024:
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1007:
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1002:
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747:(10): 2904–13.
733:
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694:Nature Medicine
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610:
584:(45): S17–S38.
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453:type 1 diabetes
445:
437:type 1 diabetes
432:
420:
389:type 1 diabetes
365:
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360:(what is this?)
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3707:
3702:
3697:
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3687:
3682:
3677:
3672:
3667:
3662:
3657:
3654:+hyaluronidase
3647:
3642:
3637:
3635:Deuruxolitinib
3632:
3627:
3622:
3617:
3612:
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3602:
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3108:+hyaluronidase
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2934:
2933:
2932:
2919:
2918:
2917:
2916:
2903:
2902:
2901:
2900:
2887:
2886:
2885:
2884:
2879:
2874:
2869:
2864:
2859:
2854:
2849:
2844:
2839:
2834:
2829:
2824:
2819:
2814:
2809:
2804:
2799:
2794:
2789:
2784:
2779:
2766:
2765:
2764:
2763:
2758:
2753:
2748:
2743:
2738:
2725:
2724:
2723:
2722:
2709:
2707:
2698:
2689:
2680:
2676:
2675:
2672:
2671:
2669:
2668:
2663:
2658:
2653:
2648:
2643:
2637:
2635:
2629:
2628:
2626:
2625:
2619:
2617:
2608:
2602:
2601:
2598:
2597:
2595:
2594:
2593:
2592:
2584:PDE4 inhibitor
2580:
2575:
2570:
2564:
2562:
2556:
2555:
2553:
2552:
2547:
2541:
2540:
2539:
2538:
2533:
2528:
2523:
2502:
2500:
2487:
2486:
2484:
2483:
2482:
2481:
2468:
2467:
2466:
2465:
2460:
2446:
2445:
2444:
2443:
2438:
2425:
2423:
2414:
2408:
2407:
2391:
2390:
2383:
2376:
2368:
2359:
2358:
2355:
2354:
2353:
2352:
2349:
2338:
2332:
2326:
2325:
2322:
2321:
2318:
2317:
2315:
2314:
2309:
2304:
2299:
2293:
2291:
2284:
2277:
2276:
2273:
2272:
2270:
2269:
2263:
2261:
2257:
2256:
2254:
2253:
2248:
2243:
2238:
2233:
2228:
2223:
2218:
2213:
2208:
2203:
2198:
2192:
2190:
2186:
2185:
2183:
2182:
2177:
2172:
2167:
2162:
2157:
2152:
2147:
2142:
2137:
2132:
2126:
2124:
2117:
2111:
2110:
2107:
2106:
2104:
2103:
2098:
2093:
2087:
2085:
2080:
2079:
2061:
2060:
2054:
2049:
2044:
2039:
2034:
2029:
2024:
2019:
2014:
2009:
2004:
1999:
1994:
1989:
1984:
1979:
1974:
1969:
1964:
1959:
1954:
1949:
1944:
1939:
1934:
1929:
1924:
1919:
1914:
1909:
1904:
1899:
1896:+hyaluronidase
1889:
1884:
1879:
1874:
1869:
1864:
1859:
1854:
1849:
1844:
1839:
1834:
1829:
1824:
1819:
1814:
1809:
1804:
1799:
1794:
1789:
1784:
1779:
1774:
1769:
1760:
1758:
1752:
1751:
1749:
1748:
1743:
1738:
1733:
1728:
1723:
1718:
1713:
1708:
1703:
1698:
1692:
1690:
1684:
1683:
1681:
1680:
1675:
1670:
1665:
1660:
1655:
1650:
1645:
1640:
1635:
1630:
1624:
1622:
1618:
1617:
1615:
1614:
1604:
1603:
1598:
1593:
1583:
1582:
1577:
1572:
1567:
1562:
1552:
1551:
1546:
1541:
1536:
1531:
1526:
1521:
1516:
1511:
1506:
1500:
1495:
1490:
1485:
1480:
1475:
1470:
1465:
1460:
1455:
1450:
1445:
1440:
1435:
1430:
1425:
1420:
1415:
1410:
1405:
1400:
1395:
1390:
1385:
1380:
1375:
1370:
1365:
1353:
1351:
1344:
1338:
1337:
1326:
1325:
1318:
1311:
1303:
1297:
1296:
1282:
1281:External links
1279:
1276:
1275:
1246:(7): 603–613.
1226:
1183:
1134:
1085:
1036:
1018:
1000:
951:
924:
905:(4): 1369–70.
889:
842:
802:
776:
727:
683:
654:(3): 1544–55.
634:
620:
564:
523:
494:
471:
470:
468:
465:
444:
441:
431:
428:
422:Teplizumab is
419:
416:
372:
371:
354:
353:
343:
337:
336:
333:
327:
321:
315:
309:
304:
298:
297:
293:
292:
290:
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281:
279:
273:
272:
270:
269:
261:
259:
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233:
225:
223:
217:
216:
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213:
205:
203:
197:
196:
192:
191:
189:
188:
175:
173:
167:
166:
162:
161:
159:
158:
145:
143:
137:
136:
131:
129:administration
123:
122:
120:
119:
101:
99:
93:
92:
89:
85:
84:
81:
75:
74:
70:
69:
64:
58:
57:
47:
41:
40:
39:Whole antibody
37:
31:
30:
15:
9:
6:
4:
3:
2:
3850:
3839:
3836:
3835:
3833:
3823:
3813:
3812:
3809:
3796:
3793:
3791:
3788:
3786:
3785:Tildrakizumab
3783:
3781:
3778:
3776:
3773:
3771:
3768:
3766:
3763:
3761:
3758:
3756:
3753:
3751:
3748:
3746:
3743:
3741:
3738:
3736:
3733:
3731:
3728:
3726:
3723:
3721:
3718:
3716:
3715:Pegcetacoplan
3713:
3711:
3708:
3706:
3703:
3701:
3698:
3696:
3693:
3691:
3688:
3686:
3683:
3681:
3678:
3676:
3673:
3671:
3668:
3666:
3663:
3661:
3658:
3655:
3651:
3648:
3646:
3643:
3641:
3638:
3636:
3633:
3631:
3628:
3626:
3625:Darvadstrocel
3623:
3621:
3618:
3616:
3613:
3611:
3608:
3606:
3603:
3601:
3598:
3596:
3593:
3591:
3588:
3586:
3583:
3581:
3578:
3577:
3575:
3571:
3561:
3558:
3556:
3553:
3551:
3548:
3544:
3541:
3539:
3536:
3535:
3534:
3533:
3532:TNF inhibitor
3529:
3525:
3522:
3520:
3517:
3516:
3515:
3514:
3510:
3509:
3507:
3504:
3499:
3489:
3486:
3484:
3481:
3480:
3478:
3476:
3472:
3462:
3459:
3457:
3454:
3452:
3449:
3447:
3444:
3442:
3439:
3437:
3434:
3432:
3429:
3427:
3424:
3422:
3419:
3417:
3414:
3412:
3409:
3407:
3404:
3402:
3399:
3397:
3394:
3392:
3389:
3387:
3384:
3382:
3379:
3377:
3374:
3372:
3369:
3367:
3364:
3363:
3361:
3357:
3350:
3346:
3345:
3341:
3340:
3335:
3332:
3330:
3327:
3325:
3322:
3321:
3320:
3319:
3315:
3314:
3309:
3306:
3305:
3304:
3303:
3299:
3295:
3292:
3291:
3290:
3289:
3285:
3281:
3278:
3276:
3273:
3272:
3271:
3270:
3266:
3262:
3259:
3257:
3254:
3252:
3249:
3248:
3247:
3246:
3242:
3238:
3235:
3234:
3233:
3230:
3229:
3224:
3221:
3219:
3216:
3215:
3214:
3213:
3209:
3205:
3202:
3201:
3200:
3199:
3198:CD147/Basigin
3195:
3191:
3188:
3187:
3186:
3185:
3181:
3177:
3174:
3173:
3172:
3171:
3167:
3163:
3160:
3158:
3155:
3154:
3153:
3152:
3148:
3144:
3141:
3139:
3136:
3135:
3134:
3133:
3129:
3125:
3122:
3120:
3117:
3115:
3112:
3109:
3105:
3102:
3100:
3097:
3096:
3095:
3094:
3090:
3086:
3083:
3082:
3081:
3080:
3076:
3072:
3069:
3068:
3067:
3066:
3062:
3058:
3055:
3053:
3050:
3048:
3045:
3044:
3043:
3042:
3038:
3034:
3031:
3029:
3026:
3024:
3021:
3019:
3018:Muromonab-CD3
3016:
3015:
3014:
3013:
3009:
3008:
3006:
3000:
2992:
2989:
2988:
2987:
2986:
2982:
2981:
2976:
2973:
2971:
2968:
2967:
2966:
2965:
2961:
2957:
2953:
2952:
2947:
2944:
2943:
2942:
2941:
2937:
2936:
2931:
2928:
2927:
2926:
2925:
2921:
2920:
2915:
2912:
2911:
2910:
2909:
2905:
2904:
2899:
2896:
2895:
2894:
2893:
2892:Interleukin 5
2889:
2888:
2883:
2880:
2878:
2875:
2873:
2872:Tildrakizumab
2870:
2868:
2865:
2863:
2860:
2858:
2855:
2853:
2850:
2848:
2845:
2843:
2840:
2838:
2835:
2833:
2830:
2828:
2825:
2823:
2820:
2818:
2815:
2813:
2810:
2808:
2805:
2803:
2800:
2798:
2795:
2793:
2790:
2788:
2785:
2783:
2780:
2778:
2775:
2774:
2773:
2772:
2768:
2767:
2762:
2759:
2757:
2754:
2752:
2749:
2747:
2744:
2742:
2739:
2737:
2734:
2733:
2732:
2731:
2727:
2726:
2721:
2718:
2717:
2716:
2715:
2711:
2710:
2708:
2706:(noncellular)
2702:
2699:
2697:
2693:
2690:
2688:
2684:
2681:
2679:Extracellular
2677:
2667:
2664:
2662:
2659:
2657:
2654:
2652:
2649:
2647:
2646:Ridaforolimus
2644:
2642:
2639:
2638:
2636:
2634:
2630:
2624:
2621:
2620:
2618:
2616:
2612:
2609:
2605:Intracellular
2603:
2591:
2588:
2587:
2586:
2585:
2581:
2579:
2576:
2574:
2571:
2569:
2566:
2565:
2563:
2561:
2557:
2551:
2548:
2546:
2543:
2542:
2537:
2534:
2532:
2529:
2527:
2524:
2522:
2519:
2518:
2517:
2516:
2512:
2508:
2504:
2503:
2501:
2498:
2492:
2488:
2480:
2477:
2476:
2475:
2474:
2470:
2469:
2464:
2463:Teriflunomide
2461:
2459:
2456:
2455:
2453:
2452:
2448:
2447:
2442:
2439:
2437:
2434:
2433:
2432:
2431:
2427:
2426:
2424:
2422:
2418:
2415:
2411:Intracellular
2409:
2404:
2400:
2396:
2389:
2384:
2382:
2377:
2375:
2370:
2369:
2366:
2350:
2348:
2345:
2344:
2342:
2339:
2336:
2333:
2331:
2328:
2327:
2323:
2313:
2310:
2308:
2305:
2303:
2300:
2298:
2295:
2294:
2292:
2288:
2285:
2283:
2280:Inflammatory
2278:
2268:
2265:
2264:
2262:
2258:
2252:
2251:Tildrakizumab
2249:
2247:
2244:
2242:
2239:
2237:
2234:
2232:
2229:
2227:
2224:
2222:
2219:
2217:
2214:
2212:
2209:
2207:
2204:
2202:
2199:
2197:
2194:
2193:
2191:
2187:
2181:
2178:
2176:
2173:
2171:
2168:
2166:
2163:
2161:
2158:
2156:
2153:
2151:
2148:
2146:
2143:
2141:
2138:
2136:
2133:
2131:
2128:
2127:
2125:
2121:
2118:
2116:
2112:
2102:
2099:
2097:
2094:
2092:
2089:
2088:
2086:
2081:
2077:
2076:
2073:
2069:
2065:
2058:
2055:
2053:
2052:Vobarilizumab
2050:
2048:
2045:
2043:
2040:
2038:
2035:
2033:
2030:
2028:
2025:
2023:
2020:
2018:
2015:
2013:
2010:
2008:
2005:
2003:
2000:
1998:
1997:Spartalizumab
1995:
1993:
1990:
1988:
1985:
1983:
1980:
1978:
1975:
1973:
1970:
1968:
1965:
1963:
1960:
1958:
1955:
1953:
1950:
1948:
1945:
1943:
1940:
1938:
1935:
1933:
1930:
1928:
1925:
1923:
1922:Pembrolizumab
1920:
1918:
1915:
1913:
1910:
1908:
1905:
1903:
1900:
1897:
1893:
1890:
1888:
1885:
1883:
1882:Mogamulizumab
1880:
1878:
1875:
1873:
1870:
1868:
1865:
1863:
1860:
1858:
1855:
1853:
1850:
1848:
1845:
1843:
1840:
1838:
1835:
1833:
1830:
1828:
1825:
1823:
1820:
1818:
1815:
1813:
1810:
1808:
1805:
1803:
1802:Crizanlizumab
1800:
1798:
1795:
1793:
1790:
1788:
1785:
1783:
1780:
1778:
1775:
1773:
1770:
1768:
1765:
1762:
1761:
1759:
1757:
1753:
1747:
1744:
1742:
1739:
1737:
1734:
1732:
1729:
1727:
1724:
1722:
1719:
1717:
1714:
1712:
1709:
1707:
1704:
1702:
1699:
1697:
1696:Andecaliximab
1694:
1693:
1691:
1689:
1685:
1679:
1676:
1674:
1671:
1669:
1666:
1664:
1661:
1659:
1656:
1654:
1651:
1649:
1646:
1644:
1641:
1639:
1636:
1634:
1631:
1629:
1626:
1625:
1623:
1619:
1613:
1609:
1606:
1605:
1602:
1599:
1597:
1594:
1592:
1588:
1585:
1584:
1581:
1578:
1576:
1573:
1571:
1568:
1566:
1563:
1561:
1557:
1554:
1553:
1550:
1547:
1545:
1542:
1540:
1537:
1535:
1532:
1530:
1527:
1525:
1522:
1520:
1517:
1515:
1512:
1510:
1507:
1504:
1501:
1499:
1496:
1494:
1491:
1489:
1486:
1484:
1481:
1479:
1476:
1474:
1471:
1469:
1466:
1464:
1461:
1459:
1456:
1454:
1451:
1449:
1446:
1444:
1441:
1439:
1436:
1434:
1431:
1429:
1426:
1424:
1421:
1419:
1416:
1414:
1411:
1409:
1406:
1404:
1401:
1399:
1396:
1394:
1391:
1389:
1386:
1384:
1381:
1379:
1376:
1374:
1371:
1369:
1366:
1364:
1360:
1359:
1355:
1354:
1352:
1348:
1345:
1343:
1342:Immune system
1339:
1335:
1334:immune system
1331:
1324:
1319:
1317:
1312:
1310:
1305:
1304:
1301:
1293:
1289:
1285:
1284:
1271:
1267:
1262:
1257:
1253:
1249:
1245:
1241:
1237:
1230:
1222:
1218:
1214:
1210:
1206:
1202:
1199:(8): 622–32.
1198:
1194:
1187:
1179:
1175:
1171:
1167:
1162:
1157:
1153:
1149:
1145:
1138:
1130:
1126:
1121:
1116:
1112:
1108:
1105:(6): 1763–9.
1104:
1100:
1096:
1089:
1081:
1077:
1072:
1067:
1063:
1059:
1055:
1051:
1047:
1040:
1032:
1028:
1022:
1014:
1010:
1004:
996:
992:
987:
982:
978:
974:
970:
966:
962:
955:
947:
943:
939:
935:
928:
920:
916:
912:
908:
904:
900:
893:
886:
885:public domain
867:
863:
861:
852:
846:
839:
838:public domain
820:
818:
812:
806:
790:
786:
780:
772:
768:
763:
758:
754:
750:
746:
742:
738:
731:
723:
719:
715:
711:
707:
706:10.1038/nm924
703:
700:(9): 1202–8.
699:
695:
687:
679:
675:
671:
667:
662:
657:
653:
649:
645:
638:
630:
624:
609:
605:
601:
597:
592:
587:
583:
579:
578:Diabetes Care
575:
568:
561:
560:public domain
542:
538:
532:
530:
528:
511:
507:
501:
499:
482:
476:
472:
464:
460:
457:
454:
450:
440:
438:
427:
425:
415:
413:
409:
404:
401:
397:
392:
390:
386:
382:
378:
368:
361:
355:
344:
342:
338:
305:
303:
299:
294:
287:
283:
282:
280:
278:
274:
267:
263:
262:
260:
258:
254:
247:
246:
244:
242:
238:
231:
227:
226:
224:
222:
218:
211:
207:
206:
204:
202:
198:
193:
187:
177:
176:
174:
172:
168:
163:
155:
150:
147:
146:
144:
142:
138:
135:
132:
130:
124:
117:
112:
103:
102:
100:
98:
94:
90:
86:
82:
80:
76:
73:Clinical data
71:
68:
65:
63:
59:
55:
51:
48:
46:
42:
38:
36:
32:
29:
25:
3795:Upadacitinib
3755:Satralizumab
3740:Ritlecitinib
3735:Risankizumab
3530:
3511:
3451:Teprotumumab
3401:Inebilizumab
3396:Fontolizumab
3376:Atorolimumab
3344:T-lymphocyte
3342:
3316:
3300:
3286:
3267:
3256:Lerdelimumab
3251:Bertilimumab
3243:
3231:
3210:
3196:
3182:
3168:
3149:
3130:
3114:Pascolizumab
3099:Obinutuzumab
3091:
3077:
3063:
3047:Clenoliximab
3039:
3027:
3023:Otelixizumab
3010:
2983:
2970:Lebrikizumab
2954:
2938:
2922:
2906:
2890:
2847:Satralizumab
2837:Risankizumab
2769:
2728:
2712:
2704:Serum target
2656:Temsirolimus
2582:
2573:Pomalidomide
2568:Lenalidomide
2526:Pimecrolimus
2505:
2479:Methotrexate
2471:
2449:
2436:Azathioprine
2428:
2413:(initiation)
2241:Risankizumab
2226:Lebrikizumab
2206:Clazakizumab
2196:Anrukinzumab
2175:Tralokinumab
2091:Otelixizumab
2071:
2063:
2062:
2032:Tregalizumab
2017:Tislelizumab
2011:
1987:Satralizumab
1967:Rontalizumab
1962:Retifanlimab
1937:Plozalizumab
1917:Pateclizumab
1912:Pascolizumab
1907:Ozoralizumab
1857:Lampalizumab
1847:Inebilizumab
1837:Fontolizumab
1787:Camrelizumab
1782:Benralizumab
1777:Atezolizumab
1763:
1706:Clenoliximab
1607:
1591:Bertilimumab
1586:
1575:Tremelimumab
1555:
1478:Mavrilimumab
1468:Lirentelimab
1463:Lerdelimumab
1438:Fresolimumab
1378:Atorolimumab
1356:
1291:
1288:"Teplizumab"
1243:
1239:
1229:
1196:
1192:
1186:
1154:(4): 302–6.
1151:
1147:
1137:
1102:
1098:
1088:
1053:
1049:
1039:
1030:
1021:
1012:
1003:
968:
964:
954:
940:(4): 381–8.
937:
933:
927:
902:
898:
892:
870:. Retrieved
857:
845:
823:. Retrieved
814:
805:
793:. Retrieved
788:
779:
744:
740:
730:
697:
693:
686:
651:
647:
637:
623:
611:. Retrieved
581:
577:
567:
545:. Retrieved
540:
514:. Retrieved
509:
485:. Retrieved
475:
461:
458:
446:
433:
421:
418:Medical uses
405:
393:
380:
376:
375:
364:
358:
171:Legal status
165:Legal status
97:License data
3790:Tofacitinib
3730:Ravulizumab
3720:Pirfenidone
3710:Peficitinib
3610:Canakinumab
3600:Briakinumab
3590:Bimekizumab
3585:Baricitinib
3550:Aflibercept
3461:Vepalimomab
3456:Vapaliximab
3431:Rovelizumab
3421:Pexelizumab
3411:Morolimumab
3386:Cedelizumab
3371:Anifrolumab
3366:Alemtuzumab
3324:Basiliximab
3294:Tocilizumab
3280:Vedolizumab
3275:Natalizumab
3261:Metelimumab
3204:Gavilimomab
3162:Toralizumab
3157:Teneliximab
3143:Lumiliximab
3138:Gomiliximab
3124:Ublituximab
3104:Ocrelizumab
3057:Zanolimumab
3033:Visilizumab
2991:Secukinumab
2975:Ustekinumab
2946:Elsilimomab
2930:Faralimomab
2898:Mepolizumab
2882:Ustekinumab
2877:Tocilizumab
2852:Secukinumab
2802:Canakinumab
2792:Briakinumab
2787:Bimekizumab
2782:Basiliximab
2771:Interleukin
2761:Nerelimomab
2666:Zotarolimus
2607:(reception)
2578:Thalidomide
2536:Voclosporin
2521:Ciclosporin
2515:Calcineurin
2511:Cyclophilin
2458:Leflunomide
2454:inhibitors
2337:from market
2307:Lemalesomab
2302:Fanolesomab
2297:Besilesomab
2236:Perakizumab
2221:Mirikizumab
2211:Gevokizumab
2201:Bimekizumab
2180:Ustekinumab
2165:Secukinumab
2150:Fezakinumab
2145:Canakinumab
2140:Briakinumab
2115:Interleukin
2068:Dostarlimab
2047:Visilizumab
2042:Vedolizumab
2037:Vatelizumab
2027:Toralizumab
2022:Tocilizumab
2007:Teclistamab
1982:Samalizumab
1972:Rovelizumab
1952:Ravulizumab
1932:Pidilizumab
1927:Pexelizumab
1892:Ocrelizumab
1887:Natalizumab
1877:Mepolizumab
1867:Ligelizumab
1862:Letolizumab
1832:Etrolizumab
1822:Epratuzumab
1792:Cedelizumab
1746:Vapaliximab
1741:Teneliximab
1731:Lumiliximab
1716:Gomiliximab
1701:Basiliximab
1673:Vepalimomab
1658:Nerelimomab
1643:Gavilimomab
1638:Faralimomab
1633:Elsilimomab
1608:Combination
1601:Zanolimumab
1596:Ontamalimab
1544:Ulocuplumab
1539:Tezepelumab
1529:Sifalimumab
1509:Pamrevlumab
1488:Morolimumab
1483:Metelimumab
1453:Lanadelumab
1388:Avdoralimab
1373:Anifrolumab
613:17 November
547:18 November
487:18 November
400:Fc receptor
352: g·mol
210:876387-05-2
195:Identifiers
134:Intravenous
88:Other names
79:Trade names
3780:Sutimlimab
3775:Spesolimab
3760:Siltuximab
3700:Olokizumab
3690:Ixekizumab
3685:Itacitinib
3675:Guselkumab
3670:Fingolimod
3665:Filgotinib
3615:Crovalimab
3605:Brodalumab
3595:Blisibimod
3560:Rilonacept
3543:Opinercept
3538:Etanercept
3524:Belatacept
3475:Polyclonal
3436:Siplizumab
3426:Reslizumab
3416:Ofatumumab
3406:Maslimomab
3391:Emapalumab
3334:Inolimomab
3329:Daclizumab
3308:Odulimomab
3223:Ruplizumab
3218:Frexalimab
3176:Aselizumab
3071:Efalizumab
3028:Teplizumab
2924:Interferon
2914:Omalizumab
2867:Spesolimab
2857:Siltuximab
2832:Rilonacept
2827:Olokizumab
2817:Ixekizumab
2812:Guselkumab
2807:Daclizumab
2797:Brodalumab
2756:Infliximab
2741:Afelimomab
2736:Adalimumab
2720:Eculizumab
2696:Monoclonal
2687:Antibodies
2661:Umirolimus
2641:Everolimus
2590:Apremilast
2550:Gusperimus
2531:Tacrolimus
2499:inhibitors
2491:Macrolides
2473:antifolate
2267:Lokivetmab
2260:Veterinary
2246:Spesolimab
2231:Olokizumab
2216:Ixekizumab
2160:Guselkumab
2155:Fletikumab
2135:Brazikumab
2130:Bermekimab
2101:Sutimlimab
2075:Ibalizumab
2012:Teplizumab
1992:Siplizumab
1977:Ruplizumab
1957:Reslizumab
1947:Quilizumab
1902:Omalizumab
1852:Itolizumab
1842:Frexalimab
1817:Efalizumab
1812:Eculizumab
1807:Daclizumab
1772:Aselizumab
1767:Apolizumab
1736:Priliximab
1721:Infliximab
1663:Odulimomab
1653:Maslimomab
1648:Inolimomab
1628:Afelimomab
1565:Durvalumab
1560:Ipilimumab
1549:Varlilumab
1519:Relatlimab
1514:Placulumab
1458:Lenzilumab
1433:Emapalumab
1418:Cemiplimab
1403:Brodalumab
1398:Bleselumab
1368:Adalimumab
872:14 January
825:22 January
795:23 January
516:4 December
467:References
463:patients.
377:Teplizumab
341:Molar mass
266:S4M959U2IJ
241:ChemSpider
201:CAS Number
116:Teplizumab
21:Teplizumab
3770:Sirukumab
3765:Siponimod
3750:Sarilumab
3725:Ponesimod
3695:Netakimab
3680:Iptacopan
3660:Etrasimod
3620:Danicopan
3555:Alefacept
3519:Abatacept
3441:Talizumab
3381:Begelomab
3237:Belimumab
3190:Galiximab
3119:Rituximab
3085:Erlizumab
3052:Keliximab
2862:Sirukumab
2842:Sarilumab
2822:Netakimab
2751:Golimumab
2651:Sirolimus
2347:Phase III
2335:Withdrawn
2312:Sulesomab
2189:Humanized
2170:Sirukumab
2002:Talizumab
1827:Erlizumab
1756:Humanized
1726:Keliximab
1711:Galiximab
1570:Nivolumab
1534:Tabalumab
1524:Sarilumab
1498:Oleclumab
1493:Namilumab
1473:Lirilumab
1448:Ianalumab
1443:Golimumab
1428:Eldelumab
1423:Dupilumab
1393:Belimumab
1363:Abrilumab
608:245451959
424:indicated
396:Fc region
127:Routes of
50:Humanized
3832:Category
3822:Medicine
3705:Ozanimod
3580:Avacopan
3573:Unsorted
3359:Unsorted
3269:Integrin
3002:Cellular
2777:Anakinra
2623:Anakinra
2545:Abetimus
2397: /
1688:Chimeric
1580:Urelumab
1503:Oxelumab
1413:Carlumab
1383:Avelumab
1332:for the
1270:31180194
1221:11868182
1213:17641665
1178:36595661
1170:19319985
1129:15919798
1099:Diabetes
1080:23835333
1050:Diabetes
995:21719095
946:16625825
866:Archived
771:16167085
722:26301557
714:12937416
678:38982992
600:34964875
510:DailyMed
443:Research
367:(verify)
221:DrugBank
141:ATC code
111:DailyMed
3501:-cept (
2282:lesions
2057:TGN1412
1942:PRO 140
1261:6776880
1120:5315015
1071:3806618
986:3191495
919:9636555
762:1201661
670:7636216
449:β-cells
430:History
302:Formula
230:DB06606
157:)
151: (
149:A10XX01
113::
3808:Portal
3513:CTLA-4
3503:Fusion
3004:target
2985:IL-17A
2962:, and
2495:other
2330:WHO-EM
2072:Other:
1268:
1258:
1219:
1211:
1176:
1168:
1127:
1117:
1078:
1068:
993:
983:
965:Lancet
944:
917:
769:
759:
720:
712:
676:
668:
606:
598:
381:Tzield
286:D09013
186:â„ž-only
184:
109:
83:Tzield
62:Target
52:(from
45:Source
3302:LFA-1
3212:CD154
3065:CD11a
2964:IL-23
2960:IL-13
2956:IL-12
2560:IMiDs
2290:Mouse
2123:Human
1621:Mouse
1587:Other
1350:Human
1217:S2CID
1174:S2CID
862:(FDA)
858:U.S.
854:(PDF)
819:(FDA)
815:U.S.
718:S2CID
674:S2CID
604:S2CID
54:mouse
3232:BLyS
3184:CD80
3151:CD40
3132:CD23
3093:CD20
3079:CD18
2940:IL-6
2633:mTOR
2507:FKBP
2497:IL-2
1266:PMID
1209:PMID
1166:PMID
1125:PMID
1076:PMID
991:PMID
942:PMID
915:PMID
874:2024
827:2023
797:2023
767:PMID
710:PMID
666:PMID
615:2022
596:PMID
549:2022
518:2022
489:2022
394:The
328:2022
322:1738
316:9938
310:6462
277:KEGG
257:UNII
248:none
35:Type
3245:CAT
3041:CD4
3012:CD3
2730:TNF
2403:L04
1256:PMC
1248:doi
1244:381
1201:doi
1156:doi
1115:PMC
1107:doi
1066:PMC
1058:doi
981:PMC
973:doi
969:378
907:doi
757:PMC
749:doi
745:115
702:doi
656:doi
652:155
586:doi
350:.49
348:801
346:145
154:WHO
67:CD3
3834::
2958:,
2343::
2066::
1610::
1589::
1558::
1361::
1290:.
1264:.
1254:.
1242:.
1238:.
1215:.
1207:.
1195:.
1172:.
1164:.
1152:25
1150:.
1146:.
1123:.
1113:.
1103:54
1101:.
1097:.
1074:.
1064:.
1054:62
1052:.
1048:.
1029:.
1011:.
989:.
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967:.
963:.
936:.
913:.
903:30
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856:.
813:.
787:.
765:.
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743:.
739:.
716:.
708:.
696:.
672:.
664:.
650:.
646:.
602:.
594:.
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580:.
576:.
539:.
526:^
508:.
497:^
414:.
334:46
180:US
106:US
3810::
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3505:)
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3110:)
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2509:/
2493:/
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1109::
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1060::
1033:.
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921:.
909::
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876:.
840:.
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520:.
331:S
325:O
319:N
313:H
307:C
182::
56:)
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