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number of 48 human chromosomes. In April 1952, Hsu discovered a techniqueâthe hypotonic solutionâthat separated the clumped chromosomes, thereby allowing him to observe each one individually Even though he now could distinguish human chromosomes to a much greater degree than his predecessors, Hsu
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Since the turn of the twentieth century, chromosomes prepared on microscope slides formed clumps that made it extremely difficult to distinguish them. Although the preparations made the identification of individual chromosomes difficult, by the 1920s, cytologists consistently reported a
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and served on the faculty at M.D. Anderson for more than 30 years. He was a UTMB GSBS Distinguished
Alumnus Award recipient in 1996. He is also a recipient of The International Center in New York's Award of Excellence.
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still reported a diploid number of 48 human chromosomes (see Figure 14 in his 1952 paper). The correct diploid chromosome number of 46 human chromosomes was first reported three years later by
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Hsu T.C., & Pomerat, C.M. (1953). Mammalian chromosomes in vitro II: A method for spreading the chromosomes of cells in tissue culture.
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Kevles, D. J. (1985). ââIn the name of eugenics: Genetics and the uses of human heredityââ. New York: Knopf.
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Hsu, T. C. (1952). Mammalian chromosomes in vitro I: The karyotype of man.
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Gartler, S. M. (2006). The chromosome number in humans: A brief history.
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Use of the hypotonic solution to observe each chromosome individually
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in 1951. Hsu worked in the laboratory of
Charles Pomerat at the
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describes Hsu and the diploid chromosome number in his book
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Human and mammalian cytogenetics: An historical perspective
190:. 1948, he went to USA, and obtained PhD from the
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284:T.C. Hsu: In memory of a rare scientist
237:His autobiography was published in the
460:Chinese emigrants to the United States
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147:; 17 April 1917 â 9 July 2003), was a
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367:Tjio J. H., & Levan A. (1956). â
239:American Journal of Medical Genetics
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384:Adam's Curse: A Future Without Men
196:University of Texas Medical Branch
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430:American Society for Cell Biology
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231:American Society for Cell Biology
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420:Cytogenetics and Genome Research
160:Father of Mammalian Cytogenetics
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192:University of Texas at Austin
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369:The chromosome number of man
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475:University of Texas faculty
358:. New York: Springer-Verlag
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465:Zhejiang University alumni
417:by S. Pathak for journal
229:Hsu was president of the
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485:Biologists from Zhejiang
480:Scientists from Shaoxing
198:during the early 1950s.
470:Educators from Shaoxing
296:Nature ReviewsâGenetics
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410:Announcement of death
381:Sykes, Bryan (2003),
455:Chinese geneticists
354:Hsu, T. C. (1979).
339:Journal of Heredity
322:Journal of Heredity
188:Zhejiang University
158:, and known as the
131:traditional Chinese
79:Zhejiang University
30:Hsu Tao-Chiuh (ćŸéèŠș)
123:simplified Chinese
394:978-0-593-05004-0
244::304-325 (1995).
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108:Cytogenetics
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61:(2003-07-09)
450:2003 deaths
445:1917 births
247:He died in
218:Bryan Sykes
59:9 July 2003
439:Categories
387:, Bantam,
328:, 167-172.
302:, 655-660.
272:References
85:(PhD 1951)
36:1917-04-17
266:Karyotype
144:XĂș DĂ ojuĂ©
75:Education
20:T. C. Hsu
426:Obituary
415:Obituary
345:, 23-29.
255:See also
180:Zhejiang
176:Shaoxing
119:T.C. Hsu
48:Zhejiang
44:Shaoxing
251:, USA.
204:diploid
50:, China
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141::
139:pinyin
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105:Fields
184:China
69:, USA
389:ISBN
211:and
166:Life
56:Died
26:Born
174:in
135:ćŸéèŠș
127:ćŸéè§
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