Shift work sleep disorder

152:. Sleep deprivation and sleep disorders are factors that contribute significantly to these errors. In the same article, the authors affirm that there is a high prevalence of sleepiness and symptoms of sleep disorders related to the circadian system in medical center nurses. In a study done with around 1100 nurses, almost half of them (49%) reported sleeping less than 7 hours per day, a significant increase compared to national figures, in which 28% of people claimed to sleep less than 7 hours per night. Having a lack of sleep can impact cognitive performance. For example, it might become difficult to stay focused and concentrate, and reaction times might also be slowed down. SWSD might interfere with making decisions quickly, driving, or flying safely. Sleep loss seen in shift workers greatly impairs cognitive performance, being awake for 24 hrs. straight results in a cognitive performance that is equal to a blood-alcohol of 0.10, which is over the legal limit in most states. All of these factors can affect work efficiency and cause accidents. Michael Lee et al. demonstrated that those working night shifts had a significantly higher risk of hazardous driving events when compared to those on a typical day shift schedule. Accidents in the workplace have been found to be 60% higher in shift workers. They can affect the individual's 169:

increased sleep deficit before morning shifts. Furthermore, the SWD group also exhibited decreased objective sleep efficiency, decrease in sleep compensation over the free days, increased sleep latency, and finally poorer sleep quality was recorded in the SWD group compared to the non-SWD group. Moreover, shift workers with SWD scored significantly higher on the Karolinska Sleepiness Scale (KSS) when assessed at the beginning and the end of morning shifts and at the end of night shifts, while having more attentional lapses at the beginning of night shifts.

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the circadian system about an hour per day) has been shown in a laboratory setting to maintain synchrony between sleep and the endogenous circadian rhythms, but this schedule is impractical for most real world settings. Some experts have advocated short runs (1 to 2 days) of night work with time for recovery; however, in the traditional heavy industries, longer (5 to 7 day) runs remain the rule. In the end, scheduling decisions usually involve maximizing leisure time, fairness in labor relations, etc. rather than

81:, or both affecting people whose work hours overlap with the typical sleep period. Insomnia can be the difficulty to fall asleep or to wake up before the individual has slept enough. About 20% of the working population participates in shift work. SWSD commonly goes undiagnosed, so it's estimated that 10–40% of shift workers have SWSD. The excessive sleepiness appears when the individual has to be productive, awake and alert. Both symptoms are predominant in SWSD. There are numerous 549:

light exposure should occur in the evening or first part of the night, and bright light should be avoided in the morning. Wearing dark goggles (avoiding bright light) or blue-blocking goggles during the morning commute home from work can improve circadian adaptation. For workers who want to use bright light therapy, appropriate fixtures of the type used to treat

369:, which found that their hypothesis of sleep deprivation and the cognitive impact it has on nurses was strongly supported in 69% of shift workers. The impairment in cognitive performance, such as general intellect, reaction time, and memory, was statistically significant among the staff nurses due to poor sleep quality and decreased alertness while awake. 443:

those who work night shifts compared to those who work day shifts. Sleepiness is manifested as a desire to nap, unintended dozing, impaired mental acuity, irritability, reduced performance, and accident proneness. Shift work is often combined with extended hours of duty, so fatigue can be a compounding factor. The symptoms coincide with the duration of

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lack entrainment to a night oriented schedule and stay on a daytime schedule. Melatonin continues to peak at night during a shift workers awake time and decreases during a shift workers sleep time. Cortisol levels are lower during a shift workers awake time and remain higher during shift workers sleep time.

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Experts agree that there is no such thing as an "ideal" night work schedule, but some schedules may be better than others. For example, rotating shifts every two weeks in a forward (delaying) direction was found to be easier than rotation in a backward (advancing) direction. Gradual delays ("nudging"

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There are different tools to assess shift work disorder. Patients can keep a diary. Some questionnaires could be useful as the Morningness-Eveningness Questionnaire. Actigraphy and polysomnography could indicate some interesting patterns. Further studies are needed to see if some phase markers as the

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SWSD can affect many occupations, but firefighters are at a greater risk because of their extended (24hr) shift and frequent sleep interruptions due to emergencies. Many firefighters have sleep disorders as a result of their extended shift and frequently disrupted sleep. In a study on firefighters by

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schedules, and they may be permanent, intermittent, or rotating; consequently, the manifestations of SWSD are quite variable. Most people with different schedules than the ordinary one (from 8 AM to 6 PM) might have these symptoms but the difference is that SWSD is continual, long-term, and starts to

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Melatonin has been shown to accelerate the adaptation of the circadian system to a nighttime work schedule. Melatonin may benefit daytime sleep in night workers by an additional direct sleep promoting mechanism. Melatonin treatment may increase sleep length during both daytime and nighttime sleep in

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analyzed the correlation between the clinical risk management and the occurrence of medication errors and the effects of the shift work on inpatient nurses. The researchers reviewed 19 out of 217 research articles and focused on the impact of workload, shifts and sleep deprivation on the probability

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in the brain, and synchronized with the day/night cycle. Gene-transcription feedback loops in individual SCN cells form the molecular basis of biological timekeeping. Circadian phase shifts are dependent on the schedule of light exposure, the intensity, and previous exposure to light. Variations in

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is the most widely used alerting drug in the world and has been shown to improve alertness in simulated night work. Caffeine and naps before a night shift reduces sleepiness during the shift. Night shift medical field workers report the highest activity, along with the least amount of sleep. These

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Circadian misalignment plays a major role in shift work sleep disorder. Circadian misalignment occurs when there is no complete adaptation to a night shift schedule. The hormones cortisol and melatonin are an important part of the circadian rhythm. In circadian misalignment, cortisol and melatonin

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Melatonin is also available as an oral supplement. In the US and Canada, the hormone melatonin is not classified as a drug; it is sold as a dietary supplement. In other countries, it requires a prescription or is unavailable. Although it is not licensed by the FDA as a treatment for any disorder,

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circadian rhythms of most species, including humans, and bright artificial light exposure has been developed as a method to improve circadian adaptation in night workers. The timing of bright light exposure is critical for its phase shifting effects. To maximize a delay of the body clock, bright

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The primary symptoms of shift work sleep disorder are insomnia and excessive sleepiness associated with working (and sleeping) at non-standard times. Shift work sleep disorder is also associated with falling asleep at work. Total daily sleep time is usually shortened and sleep quality is less in

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Although SWD affects many shift workers, its manifestation is still unclear within the general shift-working population. A field study investigating the nature of SWD in an experimental (with SWD) and control (non-SWD) group of Finnish shift workers revealed decreased total sleep time (TST) and

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Some people are more affected by shift work and sleeplessness than others, and some will be impaired on some tasks while others will always perform well on the same tasks. Some people have a morning preference but others not. Genetic predisposition is an important predictor of which people are

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skills. The participants underwent the autobiographical memory test, as well as anxiety and depression inventories. The researchers found that a sleep-deprived group of individuals scored significantly higher in the depression score and remembered more negative than positive memories. The

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There are various risk factors, including age. Although SWSD can appear at any age, the highest prevalence is in the 50 years old and above age bracket and even more so in cases of irregular schedules. Gender is also a factor. It may be that female night workers sleep less than their male

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Many night workers take naps during their breaks, and in some industries, planned napping at work (with facilities provided) is beginning to be accepted. A nap before starting a night shift is a logical prophylactic measure. However, naps that are too long (over 30 minutes) may generate

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Sleep loss and decreased quality of sleep is another effect of shift work. To promote a healthy lifestyle, the American Academy of Sleep Medicine recommended that an adult have 7 or more hours of sleep per day. Each year, there are almost 100,000 deaths estimated in the U.S. because of

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for any sleep disorders. Those with sleep disorders were also at a higher risk for being in a motor vehicle crash (OR=2.0 95% CI 1.29–3.12, p=0.0021), near crash (OR=2.49 95% CI 2.13–2.91, p < 0.0001), and nodding off while driving (OR=2.41 95% CI 2.06–2.82, p < 0.0001).

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propensity for sleep and wake. In addition to circadian misalignment, attempted sleep at unusual times can be interrupted by noise, social obligations, and other factors. There is an inevitable degree of sleep deprivation associated with sudden transitions in sleep schedule.

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The prevalence of SWSD is unclear because it is not often formally diagnosed and its definitions vary in scientific literature. However, SWSD is estimated to affect 2–10% of general population and about 27% of night and rotating workers. The use of the third edition of the

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is increased in shift workers. Because the circadian system regulates the rate of chemical substances in the body, when it is impaired, several consequences are possible. Acute sleep loss has been shown to increase the levels of

425:. It is believed that the reduction in firing in the SCN stimulates sleep. While day-active individuals produce melatonin at night, night shift workers' production of melatonin is suppressed at night due to light exposure. 553:

are readily available but patients need to be educated regarding their appropriate use, especially the issue of timing. Bright light treatment is not recommended for patients with light sensitivity or ocular disease.

221:, that plays a role in tumor suppression. Chronic shift work has been associated with decreased immune function in nurses. In a study by Naigi, et al., over the course of a shift, nurses exhibited decreasing levels of 1630:

Taraz M, Khatami MR, Hajiseyedjavadi M, Farrokhian A, Amini M, Khalili H, et al. (July 2013). "Association between antiinflammatory cytokine, IL-10, and sleep quality in patients on maintenance hemodialysis".

1775: 3098: 3083: 529:, a groggy feeling after awakening that can impair performance. Therefore, brief naps (10 to 30 minutes) are preferred to longer naps (over 30 minutes). Also, long naps may interfere with the main sleep period. 188:

which are risk factors for SWSD, have also been associated with low productivity, absenteeism, and accidents. At a cognitive level, sleep deprivation has been shown to cause decreased attentiveness, increased

421:. Typically, the secretion of melatonin begins two hours before bedtime and ends two hours prior to waking up. A decline in neuronal firing in the SCN is caused by the binding of melatonin to the MT1 and MT2 253:

Decreased sleep quality and duration have also been associated with other chronic illnesses, such as cardiovascular disease. Many studies have shown that prolonged sleeplessness and sleep disorders, such as

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after exposure compared to daytime workers. A poorly functioning immune system may leave workers vulnerable for developing occupational illnesses. Sleep loss is also associated with an increase in

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of making medication errors. They found that the main reason behind medication errors are stress, fatigue, increased workload, night shifts, nurse staffing ratio and workflow interruptions.

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Vanttola P, Puttonen S, Karhula K, Oksanen T, Härmä M (June 2020). "Prevalence of shift work disorder among hospital personnel: A cross-sectional study using objective working hour data".

573:, in the hours before bedtime allows its production. Dark therapy does not require total darkness. Amber or orange colored goggles eliminate blue light to the eyes while allowing vision. 447:

and usually remit with the adoption of a conventional sleep-wake schedule. The boundary between a "normal response" to the rigors of shift work and a diagnosable disorder is not sharp.

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AKERSTEDT T, FREDLUND P, GILLBERG M, JANSSON B (March 2002). "A prospective study of fatal occupational accidents - relationship to sleeping difficulties and occupational factors".

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These symptoms are not better explained by another sleep disorder, medical or neurologic disorder, mental disorder, medication use, poor sleep hygiene, or substance use disorder.

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There is an insomnia or/and an excessive sleepiness with a reduction of total sleep time, all combined with an overlap of work period occurring during the habitual sleep time.

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sleep-deprived group also scored significantly lower than the well-rested group in autobiographical memory and specific memories. This study is similar to the one done by the

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counterparts. A possible explanation is the social obligations that can increase their vulnerability to SWSD. Female night workers also seem to be more sleepy at work.

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Sooriyaarachchi P, Jayawardena R, Pavey T, King N. Shift work and body composition: a systematic review and meta-analysis. Minerva Endocrinology. 2021 Jun

98:(BMD) and risk for fracture. Researchers have found that those who work long-term in night positions, like nurses, are at a great risk for wrist and hip 2786:"Regulation of L1 expression and retrotransposition by melatonin and its receptor: implications for cancer risk associated with light exposure at night" 569:

in darkness, normally at night. Its production is suppressed by light exposure, principally blue light around 460 to 480 nm. Light restriction, or

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Czeisler CA, Moore-Ede MC, Coleman RH (July 1982). "Rotating shift work schedules that disrupt sleep are improved by applying circadian principles".

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459: 332: 180:, and more. In a study by Akkerstedt et al., those who had a hard time sleeping in the past two weeks were at a greater risk for having a fatal 2673: 495:

body temperature rhythm or the melatonin rhythm are efficient to assess shift work disorder. Decreased sleep quality may be assessed using the

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Brain arousal is stimulated by the circadian system during the day and sleep is usually stimulated at night. The rhythms are maintained in the

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There have been many studies suggesting health risks associated with shift work. Many studies have associated sleep disorders with decreased

2143:"Circadian rhythm sleep disorders: part I, basic principles, shift work and jet lag disorders. An American Academy of Sleep Medicine review" 682: 322:

Insomnia and wake-time sleepiness are related to misalignment between the timing of a non-standard wake–sleep schedule and the endogenous

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monitoring (with sleep diaries) demonstrate for more than 14 days (work and free days included) circadian and sleep-time misalignment.

1214:"Prevalence and impacts of poor sleep on quality of life and associated factors of good sleepers in a sample of older Chinese adults" 156:

and cause a lack of well-being and happiness. Poor sleep quality has also been associated with decreased quality of life, based on a

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are non-amphetamine alerting drugs originally developed for the treatment of narcolepsy that have been approved by the FDA (the US

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given in the morning can lengthen daytime sleep; however, some studies have shown that nighttime sleepiness may be unaffected.

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Gallo LC, Eastman CI (January 1993). "Circadian rhythms during gradually delaying and advancing sleep and light schedules".

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Wright KP, Bogan RK, Wyatt JK (February 2013). "Shift work and the assessment and management of shift work disorder (SWD)".

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practices related to sleep/wake scheduling. Symptoms typically only fully resolve once a normal sleep schedule is resumed.

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disease and tumor suppression. Other researchers have found that less sleep at night increased the risk of developing the

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were shown to be much higher in those who work night shift. SWSD can increase the risk of mental disorders. Specifically,

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exposure can advance or delay these rhythms. For example, the rhythms can be delayed due to light exposure at night.

2925:"Healthcare Shift Workers' Temporal Habits for Eating, Sleeping, and Light Exposure: A Multi-Instrument Pilot Study" 1327:

Kucharczyk ER, Morgan K, Hall AP (December 2012). "The occupational impact of sleep quality and insomnia symptoms".

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The presence of these symptoms has lasted for at least 3 months and are associated with the shift work schedules.

335:(ICSD-3) criteria has decreased the prevalence estimates of SWSD compared to the old ICSD-2 criteria after 2014. 70: 356:

Shift work sleep disorder affects many individuals, especially those within the medical field. Research done by

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Shift work sleep disorder affects patient care within all aspects of the medical field. Research published in

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to increase from the prolonged stimulation of the nervous system. The increase of inflammatory markers, like

1896:"Common sleep disorders increase risk of motor vehicle crashes and adverse health outcomes in firefighters" 602: 2029:

International Classification of Sleep Disorders 3rd Ed. Darien, IL USA: American Academy of Sleep Medicine

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Sleep disturbance is associated with impairment of social, occupational, and/or other waking functioning.

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Many studies have shown evidence of how partial and total sleep deprivation affects work productivity,

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Obtaining enough sleep during the day is a major problem for many night workers.

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In the transportation industry, safety is a major concern, and mandated

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The light-dark cycle is the most important environmental time cue for

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Partial and total sleep deprivation has been linked to an increase of

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individuals require medication/power naps to function at their best.

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1372: 507: 1780:Journal of Occupational and Environmental Medicine 1375:"Neurocognitive Consequences of Sleep Deprivation" 605:) for excessive sleepiness associated with SWSD. 3121: 2348: 2194: 2190: 2188: 2186: 1265: 1263: 1261: 1259: 2536: 2400: 864: 862: 860: 858: 856: 735: 733: 731: 460:International Classification of Sleep Disorders 333:International Classification of Sleep Disorders 2881: 2404: 2398: 2396: 2394: 2392: 2390: 2388: 2386: 2384: 2382: 2380: 2344: 2342: 2340: 2338: 2336: 1486:Archivos de Bronconeumología (English Edition) 1061: 919:https://doi.org/10.23736/s2724-6507.21.03534-x 2539:"Sleep, immunity and shift workers: A review" 2183: 2076: 1947: 1945: 1943: 1941: 1939: 1544:Journal of the American College of Cardiology 1256: 1107: 1105: 367:National Center for Biotechnology Information 2777: 2665: 2628: 2136: 2134: 2132: 2130: 2128: 2126: 2124: 2122: 853: 728: 685:. 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American Psychiatric Publications. 709: 707: 705: 703: 701: 699: 2988:The New England Journal of Medicine 2672:Kolla BP, Auger RR (October 2011). 1840:Progress in Cardiovascular Diseases 1218:Health and Quality of Life Outcomes 784: 351: 13: 2833:Sack RL, Lewy AJ (December 1997). 1900:Journal of Clinical Sleep Medicine 1884: 1822: 1528: 1474: 1363: 715:"Shift Work Sleep Disorder (SWSD)" 658: 585:Medications that promote alertness 450:There are criteria of SWSD in the 413:to the SCN. The SCN regulates the 14: 3151: 3061: 696: 89: 1792:10.1097/00043764-200211000-00005 1601:10.1111/j.1749-6632.2012.06634.x 1444:10.1046/j.1365-2869.2002.00287.x 508:Prescribed sleep/wake scheduling 346: 270:, up-regulate the production of 142: 3016: 2975: 2916: 2875: 2826: 2756: 2715: 2622: 2579: 2537:Almeida CM, Malheiro A (2016). 2530: 2487: 2312: 2288: 2231: 2035: 1767: 1718: 1667: 1623: 1572: 1423: 1320: 1205: 1146: 394:(SCN), located in the anterior 372: 258:, increases systemic levels of 114:, elevated body fat levels and 71:circadian rhythm sleep disorder 1970:10.1002/14651858.CD009776.pub2 1743:10.1001/archinternmed.2008.505 1680:Journal of Occupational Health 974: 923: 911: 804: 683:"Shift Work Disorder Symptoms" 489: 1: 2839:Journal of Biological Rhythms 2007:. Unigrafia. pp. 28–33. 1731:Archives of Internal Medicine 651: 565:is a hormone secreted by the 497:Pittsburg Sleep Quality Index 417:, which secretes the hormone 358:The Journal Of Sleep Research 2929:Journal of Circadian Rhythms 2643:10.1016/0031-9384(93)90019-C 2419:10.1016/j.patbio.2014.08.001 1118:Sleep Medicine and Disorders 1000:10.1212/WNL.0000000000008866 603:Food and Drug Administration 502: 437: 385: 7: 2555:10.1016/j.slsci.2016.10.007 1212:Lo CM, Lee PH (June 2012). 887:10.1016/j.chest.2016.12.007 624: 295: 10: 3156: 2852:10.1177/074873049701200615 2363:10.1016/j.smrv.2012.02.002 1852:10.1016/j.pcad.2008.10.003 1633:Hemodialysis International 1557:10.1016/j.jacc.2003.07.050 1498:10.1016/j.arbr.2014.12.002 1341:10.1016/j.smrv.2012.01.005 817:Osteoporosis International 3069: 2631:Physiology & Behavior 2508:10.1016/j.ncl.2019.03.003 2463:10.1002/14651858.CD008508 2244:Journal of Sleep Research 2085:Journal of Sleep Research 1432:Journal of Sleep Research 1296:10.1007/s00420-018-1386-4 829:10.1007/s00198-008-0729-5 759:10.3389/fpsyg.2021.638252 63:Shift work sleep disorder 36: 28: 24:Shift work sleep disorder 23: 2159:10.1093/sleep/30.11.1460 1087:10.1093/sleep/zsz067.628 411:retinohypothalamic tract 307:Difficulty concentrating 32:shift work disorder; SWD 2608:10.1126/science.7089576 2061:10.1093/sleep/27.8.1453 1231:10.1186/1477-7525-10-72 1180:10.1073/pnas.1510383112 746:Frontiers in Psychology 392:suprachiasmatic nucleus 362:autobiographical memory 139:effects of sleep loss. 3042:10.1093/sleep/14.2.140 2790:Nucleic Acids Research 2741:10.1093/sleep/17.6.535 2693:10.3949/ccjm.78a.10083 2351:Sleep Medicine Reviews 1693:10.1539/joh.10-0072-oa 1391:10.1055/s-0029-1237117 1329:Sleep Medicine Reviews 1080:(Supplement_1): A251. 540:Bright light treatment 429:Circadian misalignment 249:Cardiovascular disease 227:innate immune response 2901:10.1093/sleep/18.1.22 1379:Seminars in Neurology 581:night shift workers. 229:that plays a role in 3001:10.1056/NEJMoa041292 458:(DSM-5), and in the 343:vulnerable to SWSD. 318:Cause and prevalence 301:Excessive sleepiness 278:SWSD in firefighters 213:, and a decrease in 128:alcohol use disorder 96:bone mineral density 2600:1982Sci...217..460C 2407:Pathologie-Biologie 2001:Vanttola P (2021). 1593:2012NYASA1261...88R 1288:2019IAOEH..92..523V 1171:2016PNAS..113..176L 993:(11): e1181–e1189. 949:10.1155/2015/826249 558:Melatonin treatment 423:melatonin receptors 304:Difficulty sleeping 239:infectious diseases 178:workplace accidents 164:Sleep and alertness 3130:Working conditions 2802:10.1093/nar/gku503 2496:Neurologic Clinics 2091:(e12906): e12906. 752:(638252): 638252. 717:. Cleveland Clinic 201:Immune functioning 182:workplace accident 112:insulin resistance 3117: 3116: 2257:10.1111/jsr.12683 2209:10.1136/bmj.i5210 2097:10.1111/jsr.12906 2014:978-951-51-6959-4 1912:10.5664/jcsm.4534 1786:(11): 1003–1011. 1645:10.1111/hdi.12035 646:Human reliability 551:winter depression 454:(ICD-10), in the 289:medical diagnosis 217:markers, such as 215:anti-inflammatory 209:markers, such as 73:characterized by 60: 59: 18:Medical condition 3147: 3135:Circadian rhythm 3067: 3066: 3055: 3054: 3044: 3020: 3014: 3013: 3003: 2979: 2973: 2972: 2962: 2944: 2920: 2914: 2913: 2903: 2879: 2873: 2872: 2854: 2830: 2824: 2823: 2813: 2796:(12): 7694–707. 2781: 2775: 2774: 2772: 2771: 2766:. MayoClinic.com 2760: 2754: 2753: 2743: 2719: 2713: 2712: 2678: 2669: 2663: 2662: 2626: 2620: 2619: 2583: 2577: 2576: 2566: 2534: 2528: 2527: 2491: 2485: 2484: 2474: 2442: 2431: 2430: 2402: 2375: 2374: 2346: 2331: 2330: 2324: 2316: 2310: 2309: 2307: 2306: 2292: 2286: 2285: 2259: 2235: 2229: 2228: 2192: 2181: 2180: 2170: 2138: 2117: 2116: 2080: 2074: 2073: 2063: 2039: 2033: 2032: 2025: 2019: 2018: 1998: 1992: 1991: 1981: 1949: 1934: 1933: 1923: 1891: 1882: 1881: 1871: 1831: 1820: 1819: 1771: 1765: 1764: 1754: 1722: 1716: 1715: 1705: 1695: 1671: 1665: 1664: 1627: 1621: 1620: 1576: 1570: 1569: 1559: 1535: 1526: 1525: 1481: 1472: 1471: 1427: 1421: 1420: 1410: 1370: 1361: 1360: 1324: 1318: 1317: 1307: 1267: 1254: 1253: 1243: 1233: 1209: 1203: 1202: 1192: 1182: 1150: 1144: 1143: 1133: 1109: 1100: 1099: 1089: 1065: 1059: 1058: 1056: 1055: 1044: 1031: 1030: 1020: 1002: 978: 972: 971: 961: 951: 927: 921: 915: 909: 908: 898: 881:(5): 1156–1172. 866: 851: 850: 840: 808: 802: 801: 793: 782: 781: 771: 761: 737: 726: 725: 723: 722: 711: 694: 693: 691: 690: 679: 534:hours of service 515:chronobiological 352:Cognitive impact 207:pro-inflammatory 56: 55: 21: 20: 3155: 3154: 3150: 3149: 3148: 3146: 3145: 3144: 3140:Sleep disorders 3120: 3119: 3118: 3113: 3112: 3078: 3064: 3059: 3058: 3021: 3017: 2980: 2976: 2942:10.5334/jcr.199 2921: 2917: 2880: 2876: 2831: 2827: 2782: 2778: 2769: 2767: 2762: 2761: 2757: 2720: 2716: 2676: 2670: 2666: 2627: 2623: 2594:(4558): 460–3. 2584: 2580: 2535: 2531: 2492: 2488: 2457:(5): CD008508. 2443: 2434: 2403: 2378: 2347: 2334: 2322: 2318: 2317: 2313: 2304: 2302: 2294: 2293: 2289: 2236: 2232: 2193: 2184: 2153:(11): 1460–83. 2139: 2120: 2081: 2077: 2040: 2036: 2027: 2026: 2022: 2015: 1999: 1995: 1964:(8): CD009776. 1950: 1937: 1892: 1885: 1832: 1823: 1772: 1768: 1723: 1719: 1672: 1668: 1628: 1624: 1577: 1573: 1536: 1529: 1482: 1475: 1428: 1424: 1371: 1364: 1325: 1321: 1268: 1257: 1210: 1206: 1151: 1147: 1110: 1103: 1066: 1062: 1053: 1051: 1046: 1045: 1034: 979: 975: 928: 924: 916: 912: 867: 854: 809: 805: 794: 785: 738: 729: 720: 718: 713: 712: 697: 688: 686: 681: 680: 659: 654: 627: 611: 587: 560: 542: 510: 505: 492: 440: 431: 405:located in the 388: 375: 354: 349: 320: 298: 280: 251: 203: 166: 145: 102:(RR=1.37). Low 92: 50: 19: 12: 11: 5: 3153: 3143: 3142: 3137: 3132: 3115: 3114: 3111: 3110: 3095: 3079: 3074: 3073: 3071: 3070:Classification 3063: 3062:External links 3060: 3057: 3056: 3015: 2974: 2915: 2874: 2845:(6): 595–603. 2825: 2776: 2755: 2714: 2687:(10): 675–84. 2664: 2621: 2578: 2549:(3): 164–168. 2529: 2502:(3): 563–577. 2486: 2432: 2413:(5): 292–301. 2376: 2332: 2311: 2287: 2230: 2182: 2118: 2075: 2054:(8): 1453–62. 2034: 2020: 2013: 1993: 1935: 1883: 1846:(4): 294–302. 1821: 1766: 1717: 1666: 1622: 1571: 1527: 1492:(5): 213–218. 1473: 1422: 1385:(4): 320–339. 1362: 1335:(6): 547–559. 1319: 1282:(4): 523–533. 1255: 1204: 1145: 1101: 1060: 1032: 973: 922: 910: 852: 803: 783: 727: 695: 656: 655: 653: 650: 649: 648: 643: 638: 633: 626: 623: 610: 607: 586: 583: 559: 556: 541: 538: 509: 506: 504: 501: 491: 488: 487: 486: 483: 480: 470: 467: 439: 436: 430: 427: 403:Photoreceptors 387: 384: 374: 371: 353: 350: 348: 345: 319: 316: 315: 314: 313:Lack of energy 311: 308: 305: 302: 297: 294: 285:sleep disorder 279: 276: 264:blood pressure 250: 247: 223:Natural Killer 202: 199: 195:working memory 165: 162: 150:medical errors 144: 141: 137:neurocognitive 91: 90:Health effects 88: 58: 57: 40: 34: 33: 30: 26: 25: 17: 9: 6: 4: 3: 2: 3152: 3141: 3138: 3136: 3133: 3131: 3128: 3127: 3125: 3109: 3105: 3104: 3100: 3096: 3094: 3090: 3089: 3085: 3081: 3080: 3077: 3072: 3068: 3052: 3048: 3043: 3038: 3034: 3030: 3026: 3019: 3011: 3007: 3002: 2997: 2994:(5): 476–86. 2993: 2989: 2985: 2978: 2970: 2966: 2961: 2956: 2952: 2948: 2943: 2938: 2934: 2930: 2926: 2919: 2911: 2907: 2902: 2897: 2893: 2889: 2885: 2878: 2870: 2866: 2862: 2858: 2853: 2848: 2844: 2840: 2836: 2829: 2821: 2817: 2812: 2807: 2803: 2799: 2795: 2791: 2787: 2780: 2765: 2759: 2751: 2747: 2742: 2737: 2734:(6): 535–43. 2733: 2729: 2725: 2718: 2710: 2706: 2702: 2698: 2694: 2690: 2686: 2682: 2675: 2668: 2660: 2656: 2652: 2648: 2644: 2640: 2637:(1): 119–26. 2636: 2632: 2625: 2617: 2613: 2609: 2605: 2601: 2597: 2593: 2589: 2582: 2574: 2570: 2565: 2560: 2556: 2552: 2548: 2544: 2543:Sleep Science 2540: 2533: 2525: 2521: 2517: 2513: 2509: 2505: 2501: 2497: 2490: 2482: 2478: 2473: 2468: 2464: 2460: 2456: 2452: 2448: 2441: 2439: 2437: 2428: 2424: 2420: 2416: 2412: 2408: 2401: 2399: 2397: 2395: 2393: 2391: 2389: 2387: 2385: 2383: 2381: 2372: 2368: 2364: 2360: 2356: 2352: 2345: 2343: 2341: 2339: 2337: 2328: 2321: 2315: 2301: 2297: 2291: 2283: 2279: 2275: 2271: 2267: 2263: 2258: 2253: 2250:(1): e12683. 2249: 2245: 2241: 2234: 2226: 2222: 2218: 2214: 2210: 2206: 2202: 2198: 2191: 2189: 2187: 2178: 2174: 2169: 2164: 2160: 2156: 2152: 2148: 2144: 2137: 2135: 2133: 2131: 2129: 2127: 2125: 2123: 2114: 2110: 2106: 2102: 2098: 2094: 2090: 2086: 2079: 2071: 2067: 2062: 2057: 2053: 2049: 2045: 2038: 2030: 2024: 2016: 2010: 2006: 2005: 1997: 1989: 1985: 1980: 1975: 1971: 1967: 1963: 1959: 1955: 1948: 1946: 1944: 1942: 1940: 1931: 1927: 1922: 1917: 1913: 1909: 1906:(3): 233–40. 1905: 1901: 1897: 1890: 1888: 1879: 1875: 1870: 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