31:
405:. She pioneered the naked mole-rat as a model system in biomedical research. Not only does she currently maintain the world’s largest captive colony, but over the years she has provided thousands of animals to numerous laboratories across the globe to expand their use in various fields of biomedical research. Her laboratory, using a
396:
Buffenstein's current research involves determining why some mammalian species can avoid the vagaries of aging and maintain good health for the majority of their long-lifespans. She uses a comparative biology approach to address age-related changes in physiological function, most notably
313:. Her early research was primarily field-based, and addressed physiological and molecular responses of various mammals to life in extreme environments. In this regard, she has worked with over 168 different species including desert rodents in
756:
PĂ©rez, Viviana I.; Buffenstein, Rochelle; Masamsetti, Venkata; Leonard, Shanique; Salmon, Adam B.; Mele, James; Andziak, Blazej; Yang, Ting; Edrey, Yael; Friguet, Bertrand; Ward, Walter; Richardson, Arlan; Chaudhuri, Asish (2009-03-03).
174:
as an attractive counter-example to the inevitability of mammalian aging; for at ages greatly exceeding the expected maximum longevity for this mouse-sized rodent, they fail to exhibit meaningful changes in age-related risk of
387:
and also was past chair of the
Biological Sciences Section of the GSA and from 2013-2014 served as President of the American Aging Association. Rochelle is a fellow of the Cell Stress Society International.
1392:
187:
likely provide the blueprint for how to stave off myriad adverse effects of aging and provide proof of concept that age-related health decline can be avoided in humans.
369:
245:
under the mentorship of
Professors Jennifer Jarvis and Gideon Louw where her dissertation addressed many aspects of the physiological ecology of rodents living in
127:
1164:"Fibroblasts from naked mole-rats are resistant to multiple forms of cell injury, but sensitive to peroxide, ultraviolet light, and endoplasmic reticulum stress"
1407:
357:
1105:
Rodriguez, Karl A.; Valentine, Joseph M.; Kramer, David A.; Gelfond, Jonathan A.; Kristan, Deborah M.; Nevo, Eviatar; Buffenstein, Rochelle (May 2016).
709:"Successful aging and sustained good health in the naked mole rat: a long-lived mammalian model for biogerontology and biomedical research"
444:
Buffenstein has authored more than 200 publications. Along with two of her colleagues, Thomas J. Park and
Melissa M. Holmes, she published
409:
approach specifically focuses on physiological and molecular mechanisms that may contribute to the prolonged good health and longevity of
1397:
759:"Protein stability and resistance to oxidative stress are determinants of longevity in the longest-living rodent, the naked mole-rat"
360:
where she obtained numerous awards for her teaching. Bringing her colony of naked mole-rats with her, she began characterizing their
1402:
1365:
1065:
567:
414:
930:"Mechanisms of oxidative stress resistance in the brain: Lessons learned from hypoxia tolerant extremophilic vertebrates"
1278:"Resistance to experimental tumorigenesis in cells of a long-lived mammal, the naked mole-rat (Heterocephalus glaber)"
380:
607:"Negligible senescence in the longest living rodent, the naked mole-rat: insights from a successfully aging species"
270:
302:
147:
113:
238:. They returned to the laboratory with several colonies which she has maintained for more than three decades.
218:, where while a student, she worked as a research assistant to Professor Jennifer Jarvis and went with her to
214:
and was so enthralled by it that she decided she wanted a similar career in animal research. She attended the
1333:
254:
1044:
Narayan, Vikram; McMahon, Mary; O'Brien, Jonathon J.; McAllister, Fiona; Buffenstein, Rochelle (2021).
591:
384:
425:
in the extraordinary resilience of naked mole-rats against many forms of stress and disease including
402:
1046:"Insights into the Molecular Basis of Genome Stability and Pristine Proteostasis in Naked Mole-Rats"
467:"Opportunities for new insight into aging from the naked mole-rat and other non-traditional models"
928:
Garbarino, Valentina R.; Orr, Miranda E.; Rodriguez, Karl A.; Buffenstein, Rochelle (2015-06-15).
413:. She has conducted research demonstrating the astonishing finding that naked mole-rats defy the
250:
215:
67:
1276:
Liang, Sitai; Mele, James; Wu, Yuehong; Buffenstein, Rochelle; Hornsby, Peter J. (August 2010).
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Salmon, Adam B.; Sadighi Akha, Amir A.; Buffenstein, Rochelle; Miller, Richard A. (March 2008).
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361:
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770:
242:
151:
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71:
57:
824:
Hulbert, A. J.; Pamplona, Reinald; Buffenstein, Rochelle; Buttemer, W. A. (October 2007).
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where she studied several aspects of the environmental physiology of red and eastern grey
8:
211:
774:
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Edrey, Yael H.; Hanes, Martha; Pinto, Mario; Mele, James; Buffenstein, Rochelle (2011).
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1021:
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Lewis, Kaitlyn N.; Mele, James; Hayes, John D.; Buffenstein, Rochelle (November 2010).
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in a collaborative study with Dr. Timothy O’Connor. Ten years later, she moved to the
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Lewis, Kaitlyn N.; Andziak, Blazej; Yang, Ting; Buffenstein, Rochelle (2013-10-20).
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1232:
1191:
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1053:
1052:. Advances in Experimental Medicine and Biology. Vol. 1319. pp. 287–314.
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under the guidance of Prof. Terence Dawson. Following this she worked at the
204:
1057:
987:"Naked Mole-Rat mortality rates defy gompertzian laws by not increasing with age"
562:. Rochelle Buffenstein, Thomas J. Park, Melissa M. Holmes. Cham: Springer. 2021.
82:
826:"Life and death: metabolic rate, membrane composition, and life span of animals"
677:
158:
funded research and development company investigating the biology that controls
1168:
The
Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
1107:"Determinants of rodent longevity in the chaperone-protein degradation network"
841:
763:
Proceedings of the
National Academy of Sciences of the United States of America
666:
The
Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
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1352:. Advances in Experimental Medicine and Biology. Vol. 1319. 2021.
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662:"The naked mole-rat: a new long-living model for human aging research"
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143:
1221:"The naked mole-rat response to oxidative stress: just deal with it"
873:"Nrf2, a guardian of healthspan and gatekeeper of species longevity"
1161:
1043:
985:
Ruby, J. Graham; Smith, Megan; Buffenstein, Rochelle (2018-01-24).
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Rochelle’s first tenured faculty position was in the department of
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208:
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46:
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755:
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231:
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University of Texas Health
Science Center at San Antonio faculty
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234:, leading to the seminal discovery that naked mole-rats were
219:
176:
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338:
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is an
American comparative biologist currently working as
870:
203:
and grew up on a farm in the
Eastern Highlands. While at
150:. Previously, she was a senior principal investigator at
370:
University of Texas Health
Science Center at San Antonio
128:
University of Texas Health Science Center at San Antonio
465:
Buffenstein, Rochelle; Ruby, J. Graham (January 2021).
1275:
984:
706:
358:
The City College of the City University of New York
1379:
1349:The Extraordinary Biology of the Naked Mole-Rat
1050:The Extraordinary Biology of the Naked Mole-Rat
559:The extraordinary biology of the naked mole-rat
464:
446:The Extraordinary Biology of the Naked Mole-rat
372:where she was a Professor in the department of
249:environments. Thereafter, Rochelle undertook a
401:, and age-related diseases such as cancer and
166:where she used the extraordinarily long-lived
1408:Zimbabwean expatriates in the United States
659:
604:
417:. Her lab has investigated the role of the
190:
29:
1309:
1252:
1195:
1138:
1020:
1002:
961:
904:
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782:
724:
376:and further expanded her aging research.
207:she attended a talk by Dr. John Hanks on
285:at the White Mountain Research Station.
273:with Professor Richard MacmIllen on the
934:Archives of Biochemistry and Biophysics
660:Buffenstein, Rochelle (November 2005).
368:for Longevity and Aging Studies at the
126:for Longevity and Aging Studies at the
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550:
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230:of naked mole-rats in their natural
877:Integrative and Comparative Biology
611:Journal of Comparative Physiology B
13:
1225:Antioxidants & Redox Signaling
605:Buffenstein, Rochelle (May 2008).
14:
1419:
545:
513:
415:Gompertz–Makeham law of mortality
381:Gerontological Society of America
1398:City College of New York faculty
1294:10.1111/j.1474-9726.2010.00588.x
271:University of California, Irvine
1340:
1326:
1269:
1212:
1155:
1098:
1037:
978:
921:
303:University of the Witwatersrand
1403:University of Cape Town alumni
864:
817:
749:
700:
653:
598:
458:
148:University of Illinois Chicago
114:University of Illinois Chicago
1:
451:
255:University of New South Wales
1111:Cell Stress & Chaperones
1058:10.1007/978-3-030-65943-1_11
7:
537:Park, Thomas (2023-03-07).
391:
10:
1424:
842:10.1152/physrev.00047.2006
483:10.1038/s43587-020-00012-4
385:American Aging Association
1358:10.1007/978-3-030-65943-1
1123:10.1007/s12192-016-0672-x
946:10.1016/j.abb.2015.01.029
678:10.1093/gerona/60.11.1369
623:10.1007/s00360-007-0237-5
288:
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109:
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77:
63:
53:
37:
28:
21:
421:and numerous aspects of
191:Early life and education
1180:10.1093/gerona/63.3.232
784:10.1073/pnas.0809620106
379:She is a fellow of the
251:postdoctoral fellowship
216:University of Cape Town
183:decline. As such these
68:University of Cape Town
590:: CS1 maint: others (
1237:10.1089/ars.2012.4911
830:Physiological Reviews
362:negligible senescence
222:in 1980 to study the
195:Rochelle was born in
726:10.1093/ilar.52.1.41
152:Calico Life Sciences
140:Rochelle Buffenstein
117:Calico Life Sciences
58:Zimbabwean Americans
23:Rochelle Buffenstein
1004:10.7554/eLife.31157
775:2009PNAS..106.3059P
212:population dynamics
889:10.1093/icb/icq034
539:"Media - Park Lab"
352:Her career in the
241:She completed her
144:Research Professor
119:, a subsidiary of
16:American biologist
1367:978-3-030-65942-4
1231:(12): 1388–1399.
1067:978-3-030-65942-4
672:(11): 1369–1377.
569:978-3-030-65943-1
403:neurodegeneration
366:Barshop Institute
137:
136:
124:Barshop Institute
90:Scientific career
81:Aging studies in
1415:
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1338:
1337:
1334:"Google Scholar"
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411:naked mole-rats
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281:rodents in the
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83:naked mole-rats
64:Alma mater
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617:(4): 439–445.
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349:in Australia.
299:Medical School
290:
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172:naked mole-rat
156:Alphabet, Inc.
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78:Known for
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1388:Living people
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1336:. 2023-02-02.
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713:ILAR Journal
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614:
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558:
474:
471:Nature Aging
470:
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445:
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439:chemotherapy
427:UV radiation
423:proteostasis
395:
378:
351:
343:South Africa
335:golden moles
311:South Africa
307:Johannesburg
292:
283:Owens Valley
240:
194:
139:
138:
110:Institutions
104:Proteostasis
89:
345:as well as
54:Nationality
1382:Categories
1282:Aging Cell
997:: e31157.
578:1265346071
477:(1): 3–4.
452:References
441:exposure.
435:carcinogen
374:Physiology
347:marsupials
327:Madagascar
295:physiology
205:highschool
170:resistant
1302:1474-9726
1245:1557-7716
1188:1079-5006
1131:1466-1268
1092:237268341
1076:0065-2598
1013:2050-084X
954:1096-0384
897:1557-7023
850:0031-9333
793:1091-6490
735:1930-6180
686:1079-5006
631:0174-1578
586:cite book
507:234302458
491:2662-8465
448:in 2021.
407:multiomic
356:began at
331:mole-rats
267:kangaroos
263:Australia
1320:20550519
1263:23025341
1206:18375872
1149:26894765
1084:34424521
1031:29364116
972:25841340
940:: 8–16.
915:21031035
858:17928583
811:19223593
743:21411857
694:16339321
647:13598294
639:18180931
499:37117998
392:Research
383:and the
236:eusocial
224:behavior
209:elephant
201:Zimbabwe
164:lifespan
47:Zimbabwe
1311:3743245
1254:3791056
1197:2710579
1140:4837185
1022:5783610
963:4843805
906:2965188
802:2651236
771:Bibcode
431:hypoxia
323:tenrecs
315:Namibia
301:of the
297:at the
253:at the
232:habitat
228:ecology
185:rodents
146:at the
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437:, and
337:, and
289:Career
279:desert
259:Sydney
197:Harare
168:cancer
96:Fields
43:Harare
1088:S2CID
991:eLife
643:S2CID
503:S2CID
319:Kenya
220:Kenya
177:dying
160:aging
154:, an
100:Aging
1362:ISBN
1316:PMID
1298:ISSN
1259:PMID
1241:ISSN
1202:PMID
1184:ISSN
1145:PMID
1127:ISSN
1080:PMID
1072:ISSN
1062:ISBN
1027:PMID
1009:ISSN
968:PMID
950:ISSN
911:PMID
893:ISSN
854:PMID
846:ISSN
807:PMID
789:ISSN
739:PMID
731:ISSN
690:PMID
682:ISSN
635:PMID
627:ISSN
592:link
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