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Protandim

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penciled out, rapidly, about 36 of those ingredients," leaving the 5 ingredients in the current formulation of Protandim. In March 2009, former LifeLine Therapeutics executive, Paul Myhill stated, "We initially decided to hide that fact for marketing purposes and instead rely on the impeccable background of Dr. McCord." In April, 2005, Myhill produced a signed letter from McCord in which McCord stated, "I do not honestly feel that I have made contributions to the intellectual property, up to this point, that would qualify me as an inventor...I must congratulate you and Paul for having framed the concept of Protandim so close to its final embodiment, prior to the beginnings of our association."
182:, served as a spokesperson for Protandim and was responsible for distributor training and product research. Under the terms of his 2011 employment agreement, McCord received $ 529,994 in direct compensation as well as a 50-cent commission on every bottle of Protandim sold. McCord served as LifeVantage's Chief Scientific Officer from June 2011 until September 2012, and then became a member of its science advisory board. LifeVantage announced McCord's retirement in June 2013. Under the terms of the separation agreement, McCord was to receive a payment of $ 1.7 359:
prospects. Specifically, the case alleged that the defendants made false and/or misleading statements and/or failed to disclose that: (i) LifeVantage lacked effective internal financial controls; (ii) as a result, the Company had improperly accounted for sales in certain international markets, along with associated revenue and income tax accruals; and (iii) as a result of the foregoing, LifeVantage's public statements were materially false and misleading at all relevant times. The case was dismissed in June 2017.
151:; however, in 2009, after several consecutive years of multimillion-dollar losses, the company, which by then was doing business under the name LifeVantage, stopped marketing it through retailers and switched to multi-level marketing, selling it instead through a network of commissioned independent distributors. According to LifeVantage, the move from retail to multi-level marketing was prompted by the January 2008 hiring of David W. Brown, (formerly CEO and president of 103:, under the brand name "Protandim" (also sometimes referred to at that time as "Rholen," "Rejuven8r" and "ependymin"). CereMedix was a ten percent owner of Lifeline and members of the CereMedix management board served on Lifeline's board of directors. CMX-1152 was claimed to upregulate the production of the endogenous antioxidant enzymes 193:), who served as the company's chief science officer until being relieved of his duties in June 2015 and replaced in August 2015 by Natalie Chevreau, who was hired as the company's senior vice president of research and development and is credited with the invention of the company's TruScience skin care product. 201:
As recently as July 21, 2011, LifeVantage credited McCord as the creator of Protandim on its website. At a 2011 conference for LifeVantage distributors, McCord stated, "I was presented with a list of 41 potential ingredients for a product they wanted to call Protandim, and I went through the list and
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Like CMX-1152, the herbal mixture known as Protandim that supplanted it was marketed by Lifeline as an "anti-aging" supplement that increases the body's antioxidant defenses by upregulating superoxide dismutase, catalase, and glutathione peroxidase. According to the company, the product was initially
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announced on October 29, 2013, that it had partnered with LifeVantage for a long-term, multimillion-dollar jersey-front sponsorship. The partnership was set to formally go into effect on January 1, 2014, with the LifeVantage logo appearing on the Real Salt Lake jersey starting in the next season. In
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was invented following "months of extensive research and development" by Lifeline employees Paul Myhill and William Driscoll (a former oil company executive), who together hold the patent on the product, and it was launched in February 2005. Myhill and Driscoll resigned from the company later that
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In December 2012, LifeVantage issued a voluntary recall of select lots (ten lots in total comprising 247,896 bottles) of Protandim due to potential health risks arising from the possible inclusion of small metal fragments in the final product. In February 2013, the company announced that it was
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In September 2016, a class action lawsuit was filed against LifeVantage in Utah alleging that the company and its executive Darren Jensen and Mark Jaggi made false and/or misleading statements, as well as failed to disclose material adverse facts about the Company's business, operations, and
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by the U.S. Food and Drug Administration (FDA) regarding illegal advertising claims on the company's websites suggesting that Protandim can play a role in helping to cure various ailments, including cancer and diabetes. The claims were deemed to be in violation of Section 201(g)(1)(B) of the
437: 347:, based on allegations that LifeVantage had conspired with former Zrii executives to "ruin the company" and take it over “on the cheap” following a "mass exodus". The case was closed in December 2009 following LifeVantage's settlement payment of $ 400,000 to Zrii. 362:
In January 2018, a class action lawsuit was filed against LifeVantage in Connecticut alleging that the company and its chief executive officer Darren Jensen, chief sales officer Justin Rose, and chief marketing officer Ryan Goodwin were operating an illegal
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of Colorado Springs, Colorado. In July 2008, LifeVantage entered into a new manufacturing agreement with Cornerstone Research & Development to produce Protandim, and with Wasatch Product Development to produce a Protandim-based skin cream
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pill in June 2004 after completing human clinical trials. However, plans to market the CMX-1152 version of Protandim fell through and in April 2004 Lifeline Therapeutics announced that it would instead be marketing a different (non-peptide)
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On October 14, 2011, Burke Hedges, a former LifeVantage distributor (hired for his background as a speaker and trainer) filed a lawsuit with the Utah District Court against LifeVantage and its executives, seeking $
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that "we simply don't know enough at this point to recommend Protandim for treatment or prevention of any disease, for anti-aging, for making people feel healthier or more energetic, or for anything else".
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Velmurugan, Kalpana; Alam, Jawed; McCord, Joe M.; Pugazhenthi, Subbiah (2009). "Synergistic induction of heme oxygenase-1 by the components of the antioxidant supplement Protandim".
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According to the manufacturer, Protandim can cause allergic responses, gastrointestinal disturbances (stomach ache, diarrhea, vomiting), headache, and a rash on the hands and feet.
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under the name "Protandim CF" (to distinguish it from the peptide version initially developed by Cermedix). The new version of Protandim, a combination of five common
974: 435:, Myhill, Paul R. & Driscoll, William J., "Composition for alleviating inflammation and oxidative stress in a mammal.", issued 10 July 2007 95:
licensing and marketing company, entered into an agreement with Massachusetts biotechnology company CereMedix for the rights to market CMX-1152, an experimental
83:(FDA) regarding illegal advertising claims on the company's websites suggesting that Protandim can help to cure various ailments, including cancer and diabetes. 2327: 67:
mix of five herbal ingredients and sold by LifeVantage Corporation (formerly LifeLine Therapeutics, Lifeline Nutraceuticals, and Yaak River Resources, Inc), a
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company. The manufacturers of Protandim make no claims that it can prevent or cure any medical conditions. In 2017, LifeVantage was issued a
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extending the recall to include additional lots of the product, estimating the total cost of the recall at $ 5.9 million.
817:"Paul R. Myhill. RE: Resignation from the Board of Directors and Executive Committee of Lifeline Therapeutics, Inc (Form 8-K)" 816: 578: 978: 843: 2332: 1616: 899: 477: 332: 1762: 702: 1049: 1514: 80: 1421: 1027: 1425: 291: 1876: 554: 878: 2342: 1755: 1002: 2120: 764: 685: 279: 174:
joined the LifeVantage board of directors as the company's director of science. McCord, who is listed by the
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Protandim consists mainly of a blend of five herbal ingredients (amounts per caplet listed in parentheses):
2317: 1866: 1596:"Rosen Law Firm Announces Filing of Securities Class Action Lawsuit Against LifeVantage Corporation – LFVN" 869:"LifeVantage Corporation Appoints Industry Veteran David Brown as President & CEO (LFVN press release)" 495: 2216: 1075:"Dr. Joe McCord, LifeVantage Corporation's First Chief Science Officer, Retires from Company Nasdaq:LFVN" 496:"Real Salt Lake: RSL jersey sponsor LifeVantage in hot water with FDA over supplement's treatment claims" 343:
In 2009, LifeVantage was sued by Utah-based Zrii LLC, a marketer of nutritional fruit drinks endorsed by
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marketed with unsupported claims that it can treat a number of medical conditions. The product is a
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million in punitive damages over allegations of wrongful termination and tortious interference.
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is of poor quality, casting doubt on its usefulness for drawing any conclusions about efficacy.
2036: 1466: 112: 1583:, United States District Court for the District of Utah: Civil No. 110918424, October 14, 2011 1256: 2226: 2176: 2140: 2076: 1841: 1778: 72: 2201: 2196: 1981: 104: 1155:"LifeVantage Corporation Appoints Shawn Talbott Ph.D. as New Global Chief Science Officer" 949: 8: 2125: 1203:"Patent WO 2015164504 A1: Topical compositions and methods for reducing oxidative stress" 379: 1331: 615: 2166: 2061: 2046: 1402: 679: 327: 234: 127: 76: 60: 1202: 2271: 2251: 2081: 1406: 1394: 1335: 1232: 499: 100: 1253:"The History of Free Radical Biology, Dr. Joe McCord [Filed 17 August 2011]" 2066: 1961: 1861: 1488: 1384: 1327: 1177: 214: 119: 1747: 1389: 1372: 2261: 2011: 586: 473: 388: 286: 224: 179: 64: 1712:"Real Salt Lake unveils new long-term jersey-front partnership with LifeVantage" 915:
David Brown, President of LifeVantage Network, recognized Protandim's potential.
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Beginning in 2005, Protandim was produced under a manufacturing agreement with
1951: 1901: 1851: 1795: 383: 364: 1129:"Three Cortislim Defendants to Give up $ 4.5 Million in Cash and Other Assets" 2311: 2211: 2186: 2171: 2115: 2041: 1996: 1986: 1846: 1298:"McCord Rejects Credit for Inventing Protandim [Filed 29 March 2005]" 1102: 344: 171: 92: 1595: 2145: 2051: 1826: 1398: 1339: 1278:"Inside Protandim: The Paul Myhill Interview [Filed 09 March 2009]" 707: 371:, federal securities laws, and the Connecticut Unfair Trade Practices Act. 2286: 2056: 1921: 1856: 1558: 738: 148: 2231: 2181: 1971: 275: 152: 122: 1536:"LIFEVANTAGE CORP, Form 8-K, Current Report, Filing Date Feb 13, 2013" 950:"LIFEVANTAGE CORP, Form 10-K, Annual Report, Filing Date Sep 28, 2011" 2291: 2266: 2026: 2001: 1946: 1906: 734:"Denver Businessmen Gamble on Selling Fountain of Youth in Pill Form" 530: 244: 190: 139: 844:"Protandim to be Available at General Nutrition Center (GNC) Stores" 527:"FDA warns RSL kit sponsor LifeVantage over cancer treatment claims" 189:
In January 2014, McCord was replaced by Shawn Talbott (developer of
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to have bought a 5.1 percent ownership stake in LifeVantage.
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In 2003, Lifeline Therapeutics, a privately held Denver-based
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Marketing claims that Protadim can prevent or treat
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Archived from the original on 21 July 2011. 727: 725: 635: 600: 312: 251:) extract (98% polyphenols, 45% EGCG) (75 mg) 2192:European Grouping of Marketing Professionals 1097: 1095: 992: 861: 652: 489: 487: 326:On April 17, 2017, LifeVantage was issued a 1587: 1169: 697: 695: 15: 1770: 1756: 1634: 1453: 1121: 1050:"Employment agreement with Dr. Joe McCord" 1003:"MCCORD JOE M ALL SEC FILINGS - SEC Watch" 722: 524: 444: 374: 16: 1972:Juice Plus AKA National Safety Associates 1704: 1388: 1092: 892: 757: 549: 547: 484: 427: 425: 1678: 809: 692: 24:This is an accepted version of this page 1581:Burke Hedges V. Lifevantage Corporation 1346: 1147: 1067: 1054:U.S. Securities and Exchange Commission 1020: 494:Kamrani, Christopher (April 26, 2017). 493: 393:U.S. Securities and Exchange Commission 176:U.S. Securities and Exchange Commission 14: 2310: 1656: 1609: 1573: 1556: 1311: 731: 544: 472: 466: 422: 155:) as the company's CEO and president. 118:CMX-1152 was due to be marketed as an 53:American multi-level marketing company 1751: 1594:Rosen Law Firm (September 16, 2016). 765:"Some days it's just hard to believe" 629: 520: 518: 516: 221:) extract (70–80% Silymarin) (225 mg) 147:sold through retail channels such as 1714:. RealSaltLake.com. October 29, 2013 1550: 1459: 1422:"Pursued by Protandim Proselytizers" 1419: 1356:. FDA. 25 April 2017. Archived from 333:Federal Food, Drug, and Cosmetic Act 196: 1332:10.1016/j.freeradbiomed.2008.10.050 1157:. LifeVantage, Inc. January 7, 2014 848:Lifeline Therapeutics press release 836: 790:"Lifeline Therapeutics CEO resigns" 782: 732:Austin, Marsha (December 8, 2003). 525:Montgomery, Matt (April 26, 2017). 231:) extract (45% bacosides) (150 mg) 115:, and to offset the aging process. 48: 1743:Pursued by Protandim Proselytizers 1460:Hall, Harriet (December 5, 2017). 1176:Shawn M. Talbott (July 13, 2015). 902:. LifeVantage, Inc. Archived from 877:. January 14, 2008. Archived from 658: 614:. December 1, 2004. Archived from 585:. December 1, 2003. Archived from 513: 274:are unproven and have been deemed 49: 2354: 2338:Companies based in Salt Lake City 1730: 1515:U.S. Food and Drug Administration 1420:Hall, Harriet (11 October 2011). 1320:Free Radical Biology and Medicine 555:"2017 – Lifevantage Corp 4/17/17" 322:FDA Warning for illegal marketing 81:U.S. Food and Drug Administration 1491:(Press release). 5 December 2012 1373:"ALSUntangled No. 31: Protandim" 387:July 2015, Real Salt Lake owner 265: 261:) extract (95% curcumin) (75 mg) 1739:, the manufacturer of Protandim 1644:. Lifevantage. October 10, 2017 1503: 1481: 1439: 1413: 1364: 1103:"Form 8-K for LifeVantage Corp" 967: 636:Alison McCook (February 2006). 299: 2323:Multi-level marketing products 1182:Shawn M. Talbott Personal Blog 661:"The Uncertain Antiaging Pill" 205: 13: 1: 1462:"I Was Wrong about Protandim" 1390:10.3109/21678421.2015.1088707 415: 280:amyotrophic lateral sclerosis 1877:Discount Home Shoppers' Club 1867:Crowd Sourcing International 1028:"LifeVantage Corp 10-K 2011" 7: 2333:2003 establishments in Utah 2217:International Heritage Inc. 1371:ALSUntangled Group (2015). 398: 308:Legal and regulatory issues 10: 2359: 2277:United Sciences of America 2121:Nature's Sunshine Products 1897:Fuel Freedom International 1557:Harvey, Tom (2009-12-23). 638:"Your Money for Your Life" 313:Protandim voluntary recall 186:million from the company. 86: 2207:Fortune Hi-Tech Marketing 2159: 2090: 1804: 1786: 684:: CS1 maint: unfit URL ( 480:. Science-Based Medicine. 1133:Federal Trade Commission 338: 31:latest accepted revision 2111:LifeVantage Corporation 1927:The Longaberger Company 1887:Forever Living Products 1737:LifeVantage Corporation 900:"The LifeVantage Story" 795:Denver Business Journal 450:LifeVantage Corporation 375:Promotional sponsorship 2037:Southwestern Advantage 1467:Science Based Medicine 1426:Science-Based Medicine 1030:. sec.edgar-online.com 292:Science-Based Medicine 134:ingredients including 113:glutathione peroxidase 2343:Health fraud products 2227:Koscot Interplanetary 2177:Black Oxygen Organics 2141:Usana Health Sciences 2077:World Financial Group 1842:Arbonne International 1779:Multi-level marketing 73:multi-level marketing 2202:Excel Communications 2197:European Home Retail 1982:North American Power 1977:Neal's Yard Remedies 1622:. September 15, 2018 1135:. September 21, 2005 583:Nutraceuticals World 453:"FAQs – LifeVantage" 391:was reported by the 367:in violation of the 287:Harriet A. Hall 170:In 2006, biochemist 105:superoxide dismutase 2318:Dietary supplements 2126:Nu Skin Enterprises 1692:. February 19, 2018 1561:. Salt Lake Tribune 825:. November 11, 2005 771:. November 17, 2005 711:. November 17, 2003 618:on January 25, 2005 380:Major League Soccer 180:insider shareholder 160:The Chemins Company 21:Page version status 2167:Aman Futures Group 2062:Usborne Publishing 2047:Success University 1205:. October 29, 2015 239:Withania somnifera 172:Joe M. McCord 128:dietary supplement 61:dietary supplement 27: 2305: 2304: 2272:The Trump Network 2252:Royal Tongan Limu 2082:YTB International 1538:. secdatabase.com 1360:on 24 April 2018. 955:. secdatabase.com 930:. secdatabase.com 659:Bailey, Patrick. 589:on April 13, 2016 500:Salt Lake Tribune 249:Camellia sinensis 241:) powder (150 mg) 197:Product invention 178:as a LifeVantage 18: 2350: 2067:Vector Marketing 1962:Modi Enterprises 1772: 1765: 1758: 1749: 1748: 1724: 1723: 1721: 1719: 1708: 1702: 1701: 1699: 1697: 1682: 1676: 1675: 1673: 1671: 1660: 1654: 1653: 1651: 1649: 1638: 1632: 1631: 1629: 1627: 1621: 1613: 1607: 1606: 1604: 1602: 1591: 1585: 1584: 1577: 1571: 1570: 1568: 1566: 1554: 1548: 1547: 1545: 1543: 1532: 1526: 1525: 1523: 1521: 1507: 1501: 1500: 1498: 1496: 1485: 1479: 1478: 1476: 1474: 1457: 1451: 1450: 1449:. protandim.com. 1443: 1437: 1436: 1434: 1432: 1417: 1411: 1410: 1392: 1368: 1362: 1361: 1350: 1344: 1343: 1315: 1309: 1308: 1306: 1305: 1294: 1288: 1287: 1285: 1284: 1274: 1268: 1267: 1265: 1264: 1255:. 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Index

latest accepted revision
reviewed
dietary supplement
patented
Utah
multi-level marketing
warning letter
U.S. Food and Drug Administration
nutraceutical
peptide
compound
superoxide dismutase
catalase
glutathione peroxidase
over the counter
anti-aging
dietary supplement
herbal
turmeric
green tea
GNC
Metabolife
The Chemins Company
Joe M. McCord
U.S. Securities and Exchange Commission
insider shareholder
CortiSlim
Milk thistle
Bacopa
Ashwagandha

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