1207:
found evidence that serum levels of dabigatran vary widely. The BMJ investigation suggested that
Boehringer had a financial motive to withhold this concern from regulatory health agencies because the data conflicted with their extensive marketing of dabigatran as an anticoagulant that does not require monitoring. In August 2012, Pradaxa claims filed in U.S. federal courts were consolidated into a multi-district litigation in the Southern District of Illinois before Chief Judge David R. Herndon. In May 2014, a $ 650 million settlement was announced on behalf of approximately 3,900 claimants who were injured by the drug Pradaxa made by Boehringer Ingelheim Pharmaceuticals, Inc. The drug was alleged to cause severe bleeding events and/or hemorrhaging to those who were taking the drug.
649:
42:
1024:. In a 2016 study by Toya et al., roughly 20% of patients suffered esophageal mucosa damage. It has been theorized that the tartaric-acid core in the drug adheres and damages the esophagus, and then the damaged esophageal mucosa exfoliates after peristalsis. Additionally, patients with limited mobility, reduced salivary secretion, and low water consumption will increase the possibility of contact by dabigatran with the esophageal mucosa.
4353:
1206:
pharmaceutical group of withholding critical information about the need for monitoring to protect patients from severe bleeding, particularly in the elderly. Review of internal communications between
Boehringer researchers and employees by the FDA and the EMA revealed that Boehringer researchers had
1012:
A small but significantly increased risk of myocardial infarctions (heart attacks) has been noted when combining the safety outcome data from multiple trials. However, conflicting evidence from another review suggested that dabigatran might not substantially increase the risk of heart attacks, or if
991:
The most commonly reported side effect of dabigatran is gastrointestinal upset. When compared with people anticoagulated with warfarin, patients taking dabigatran had fewer life-threatening bleeds, fewer minor and major bleeds, including intracranial bleeds, but the rate of gastrointestinal bleeding
979:
guidelines states that patients with mechanical heart valves should not be using dabigatran. The safety and efficacy of
Pradaxa (dabigatran) were evaluated in the European RE-ALIGN trial in 2012. RE-ALIGN was terminated early because the Pradaxa treatment group had significantly more thromboembolic
1198:
In May 2014, the FDA reported the results of a large study comparing dabigatran with warfarin in 134,000 Medicare patients. The agency concluded that dabigatran is associated with a lower risk of overall mortality, ischemic stroke, and bleeding in the brain than warfarin. Gastrointestinal bleeding
962:
Dabigatran is contraindicated in patients who have active pathological bleeding, since dabigatran can increase bleeding risk and can also cause serious and potentially life-threatening bleeds. Dabigatran is also contraindicated in patients who have a history of serious hypersensitivity reaction to
953:
In 2022, an observational meta-analysis study was performed on direct oral anticoagulants for patients with atrial fibrillation. The study found that dabigatran had comparable rates of ischemic stroke or systemic embolism, intracerebral haemorrhage, and all-cause mortality when compared to other
2220:
Hijazi Z, Hohnloser SH, Oldgren J, Andersson U, Connolly SJ, Eikelboom JW, et al. (March 2014). "Efficacy and safety of dabigatran compared with warfarin in relation to baseline renal function in patients with atrial fibrillation: a RE-LY (Randomized
Evaluation of Long-term Anticoagulation
1004:
RA), proton pump inhibitors (PPIs) and mucosal protective agent. In severe bleeding, measures include discontinuation of dabigatran immediately, and administration of prothrombin complex concentrate, packed red blood cells, fresh frozen plasma, the use of specific reversal agents such as
2169:
Wei AH, Gu ZC, Zhang C, Ding YF, Liu D, Li J, et al. (September 2018). "Increased risk of myocardial infarction with dabigatran etexilate: fact or fiction? A critical meta-analysis of over 580,000 patients from integrating randomized controlled trials and real-world studies".
1808:
Lau WC, Torre CO, Man KK, Stewart HM, Seager S, Van Zandt M, et al. (November 2022). "Comparative
Effectiveness and Safety Between Apixaban, Dabigatran, Edoxaban, and Rivaroxaban Among Patients With Atrial Fibrillation : A Multinational Population-Based Cohort Study".
954:
anticoagulants like apixaban, edoxaban, and rivaroxaban. Notably, apixaban was associated with a lower risk of gastrointestinal bleeding than dabigatran and the others. This finding was generally steady for patients aged 80 years or older and those with chronic kidney disease.
1191:(FDA) approved Pradaxa in October 2010, for prevention of stroke in patients with non-valvular atrial fibrillation. The approval came after an advisory committee recommended the drug for approval in September 2010, although caution is still urged by some outside experts.
1016:
For patients with moderately reduced kidney function, lower dabigatran doses are recommended due to increased drug exposure and bleeding risk. Alternative anticoagulants should be considered in severe kidney impairment due to insufficient safety and efficacy data.
1068:
of the drug is unaffected. Several studies have demonstrated that dabigatran plasma concentrations are reduced when co-administered with proton pump inhibitors, however it is unclear if this reduction is clinically significant. Dabigatran excretion through
2782:
van Ryn J, Stangier J, Haertter S, Liesenfeld KH, Wienen W, Feuring M, et al. (June 2010). "Dabigatran etexilate--a novel, reversible, oral direct thrombin inhibitor: interpretation of coagulation assays and reversal of anticoagulant activity".
1157:(NHS) in Britain authorized dabigatran for use in preventing blood clots in hip and knee replacement surgery patients. According to a BBC article in 2008, Dabigatran was expected to cost the NHS ÂŁ4.20 per day, which was similar to several other
2529:
Stangier J, Eriksson BI, Dahl OE, Ahnfelt L, Nehmiz G, StÀhle H, et al. (May 2005). "Pharmacokinetic profile of the oral direct thrombin inhibitor dabigatran etexilate in healthy volunteers and patients undergoing total hip replacement".
789:
as etexilate: InChI=1S/C34H41N7O5/c1-4-6-7-10-21-46-34(44)39-32(35)24-12-15-26(16-13-24)37-23-30-38-27-22-25(14-17-28(27)40(30)3)33(43)41(20-18-31(42)45-5-2)29-11-8-9-19-36-29/h8-9,11-17,19,22,37H,4-7,10,18,20-21,23H2,1-3H3,(H2,35,39,44)
980:
events and major bleeding than warfarin and determined to be contraindicated for use in patients with mechanical heart valves. Further studies are needed in order to determine effects of dabigatran on patients with bioprosthetic valves.
2205:
Stangier J, Rathgen K, StÀhle H, Mazur D. Influence of renal impairment on the pharmacokinetics and pharmacodynamics of oral dabigatran etexilate: an open-label, parallel-group, single-centre study. Clinical pharmacokinetics. 2010 Apr;
1199:
was more common in those treated with dabigatran than in those treated with warfarin. The risk of heart attack was similar between the two drugs. The FDA reiterated its opinion that dabigatran's overall risk/benefit ratio is favorable.
3274:
3223:"2011 ACCF/AHA/HRS focused update on the management of patients with atrial fibrillation (update on Dabigatran): a report of the American College of Cardiology Foundation/American Heart Association Task Force on practice guidelines"
1935:
730:
1194:
In
February 2011, the American College of Cardiology Foundation and the American Heart Association added dabigatran to their guidelines for management of non-valvular atrial fibrillation with a class I recommendation.
2256:
An J, Cheetham TC, Luong T, Lang DT, Lee MS, Reynolds K (July 2023). "Effectiveness and safety of
Dabigatran 110 mg versus 150 mg for Stroke Prevention in Patients with Atrial Fibrillation at High Bleeding Risk".
3391:
2817:
Although there is no specific antidote to antagonise the anticoagulant effect of dabigatran, due to its short duration of effect drug discontinuation is usually sufficient to reverse any excessive anticoagulant
3177:
Merli G, Spyropoulos AC, Caprini JA (August 2009). "Use of emerging oral anticoagulants in clinical practice: translating results from clinical trials to orthopedic and general surgical patient populations".
967:
or anaphylactic shock). The use of dabigatran should also be avoided in patients with mechanical prosthetic heart valves due to the increased risk of thromboembolic events (e.g. valve thrombosis, stroke, and
861:; however, dabigatran were associated with a lower hazard for intracranial bleeding compared with warfarin, but also had a higher risk of gastrointestinal bleeding relative to warfarin. It is taken by mouth.
722:
1183:
in June 2008, for the prevention of blood clots in patients who have undergone total hip or total knee replacement surgery. Approval for atrial fibrillation patients at risk of stroke came in
October 2010.
1064:
Dabigatran has a half-life of approximately 12â17 h and exerts a maximum anticoagulation effect within 2 hours after ingestion. Fatty foods delay the intestinal absorption of dabigatran, although the
1164:
Initially, there was no specific way to reverse the anticoagulant effect of dabigatran in the event of a major bleeding event, unlike for warfarin. Since then, the dabigatran-specific antidote
2945:
3263:"FDA Drug Safety Communication: FDA study of Medicare patients finds risks lower for stroke and death but higher for gastrointestinal bleeding with Pradaxa (dabigatran) compared to warfarin"
3262:
2622:
Bolek T, SamoĆĄ M, StanÄiakovĂĄ L, IvankovĂĄ J, Ć korĆovĂĄ I, StaĆĄko J, et al. (May 2019). "The Impact of Proton Pump
Inhibition on Dabigatran Levels in Patients With Atrial Fibrillation".
992:
was significantly higher. Dabigatran capsules contain tartaric acid, which lowers the gastric pH and is required for adequate absorption. The lower pH has previously been associated with
1927:
1027:
The
Randomized Evaluation of Long-Term Anticoagulation Therapy (RE-LY) trial showed that impairment of liver function caused by dabigatran occurred in the same frequency as warfarin.
248:
2924:
778:
InChI=1S/C25H25N7O3/c1-31-20-10-7-17(25(35)32(13-11-23(33)34)21-4-2-3-12-28-21)14-19(20)30-22(31)15-29-18-8-5-16(6-9-18)24(26)27/h2-10,12,14,29H,11,13,15H2,1H3,(H3,26,27)(H,33,34)
996:; some hypothesize that this plays a role in the increased risk of gastrointestinal bleeding. If a small amount of GI bleeding is diagnosed, the clinicians may consider adding H
2662:
1331:
3381:
2996:
Connolly SJ, Ezekowitz MD, Yusuf S, Eikelboom J, Oldgren J, Parekh A, et al. (September 2009). "Dabigatran versus warfarin in patients with atrial fibrillation".
2376:
Connolly SJ, Ezekowitz MD, Yusuf S, Eikelboom J, Oldgren J, Parekh A, et al. (September 2009). "Dabigatran versus warfarin in patients with atrial fibrillation".
2124:
Connolly SJ, Ezekowitz MD, Yusuf S, Eikelboom J, Oldgren J, Parekh A, et al. (September 2009). "Dabigatran versus warfarin in patients with atrial fibrillation".
983:
Dabigatran is poorly excreted in breastmilk and does not appear to require any limitations to breastfeeding. However, data is limited and further studies are needed.
2292:
Toya Y, Nakamura S, Tomita K, Matsuda N, Abe K, Abiko Y, et al. (March 2016). "Dabigatran-induced esophagitis: The prevalence and endoscopic characteristics".
3155:
4428:
1611:
203:
1661:"Dabigatran, Rivaroxaban, or Apixaban versus Warfarin in Patients with Nonvalvular Atrial Fibrillation: A Systematic Review and Meta-Analysis of Subgroups"
1786:
857:
and does not require monitoring by blood tests. In a meta analysis of 7 different studies, there was no benefit of dabigatran over warfarin in preventing
805:
3120:
3098:
123:
4393:
2955:
2683:
Hauel NH, Nar H, Priepke H, Ries U, Stassen JM, Wienen W (April 2002). "Structure-based design of novel potent nonpeptide thrombin inhibitors".
1416:
2718:
1928:"FDA Drug Safety Communication: Pradaxa (dabigatran etexilate mesylate) should not be used in patients with mechanical prosthetic heart valves"
1853:"FDA Drug Safety Communication: Pradaxa (dabigatran etexilate mesylate) should not be used in patients with mechanical prosthetic heart valves"
1116:-alpha-(2-naphthylsulfonylglycyl)-4-amidinophenylalanine piperidide), which had been known since the 1980s as a powerful inhibitor of various
72:
744:
2921:
4094:
3497:
3492:
1361:
4193:
3431:
2659:
3523:
2575:"Influence of proton pump inhibitors on blood dabigatran concentrations in Japanese patients with non-valvular atrial fibrillation"
2979:
2085:"Dabigatran association with higher risk of acute coronary events: meta-analysis of noninferiority randomized controlled trials"
1323:
1288:
3409:
1864:
2482:"Dabigatran: A new oral anticoagulant. Guidelines to follow in oral surgery procedures. A systematic review of the literature"
4307:
1577:
1232:
900:
2760:
1973:
1467:"Dabigatran Versus Warfarin for Atrial Fibrillation in Real-World Clinical Practice: A Systematic Review and Meta-Analysis"
4408:
3144:
950:
in preventing non-hemorrhagic strokes and embolic events in those with atrial fibrillation not due to valve problems.
812:
140:
3678:
1525:
1449:
1154:
770:
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Muñoz-Corcuera M, RamĂrez-MartĂnez-Acitores L, LĂłpez-Pintor RM, Casañas-Gil E, HernĂĄndez-Vallejo G (November 2016).
4324:
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233:
104:
1633:
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3623:
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4054:
1712:"Interventions for Preventing Thromboembolic Events in Patients With Atrial Fibrillation: A Systematic Review"
428:
420:
3424:
1710:
Lowenstern A, Al-Khatib SM, Sharan L, Chatterjee R, Allen LaPointe NM, Shah B, et al. (December 2018).
4423:
3907:
3268:
3128:
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3090:
2034:"Dabigatran must be used carefully: literature review and recommendations for management of adverse events"
1858:
1605:
1188:
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976:
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495:
2728:
1886:
Eikelboom JW, Connolly SJ, Brueckmann M, Granger CB, Kappetein AP, Mack MJ, et al. (September 2013).
1254:
3998:
3718:
628:
589:
581:
4418:
4343:
1104:
Dabigatran (then compound BIBR-953) was discovered from a panel of chemicals with similar structure to
1089:
758:
as etexilate: CN1C=2C(=CC(C(N(CCC(OCC)=O)C3=CC=CC=N3)=O)=CC2)N=C1CNC4=CC=C(C(NC(OCCCCCC)=O)=N)C=C4
2337:"Analysis of upper gastrointestinal adverse events among patients given dabigatran in the RE-LY trial"
1994:
Blommel ML, Blommel AL (August 2011). "Dabigatran etexilate: A novel oral direct thrombin inhibitor".
903:. In 2020, it was the 306th most commonly prescribed medication in the United States, with more than 1
4046:
2977:"Pradax (Dabigatran Etexilate) Gains Approval In Canada For Stroke Prevention In Atrial Fibrillation"
2723:
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893:
196:
118:
82:
644:
4383:
3417:
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3221:
Wann LS, Curtis AB, Ellenbogen KA, Estes NA, Ezekowitz MD, Jackman WM, et al. (March 2011).
3150:
177:
54:
17:
3439:
1759:
Sanders GD, Lowenstern A, Borre E, Chatterjee R, Goode A, Sharan L, et al. (October 2018).
1659:
GĂłmez-Outes A, Terleira-FernĂĄndez AI, Calvo-Rojas G, SuĂĄrez-Gea ML, Vargas-CastrillĂłn E (2013).
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322:
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561:
553:
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2335:
Bytzer P, Connolly SJ, Yang S, Ezekowitz M, Formella S, Reilly PA, et al. (March 2013).
1515:
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332:
8:
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3641:
3337:
Moore TJ, Cohen MR, Mattison DR (July 2014). "Dabigatran, bleeding, and the regulators".
2573:
Kuwayama T, Osanai H, Ajioka M, Tokuda K, Ohashi H, Tobe A, et al. (December 2017).
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1834:
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1711:
1687:
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151:
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in persons who have been treated for 5â10 days with parenteral anticoagulant (usually
400:
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3937:
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3917:
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2011:
1965:
1909:
1852:
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1741:
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1280:
943:), and to prevent deep vein thrombosis and pulmonary embolism in some circumstances.
600:
285:
272:
260:
96:
3366:
3207:
2908:
2879:
Syed YY (August 2016). "Idarucizumab: A Review as a Reversal Agent for Dabigatran".
2812:
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2003:
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1768:
1731:
1723:
1682:
1672:
1549:
1500:
1478:
1045:
899:
Dabigatran was approved for medical use in the United States in 2010. It is on the
889:
850:
665:
392:
304:
216:
1761:
Stroke Prevention in Patients With Atrial Fibrillation: A Systematic Review Update
1658:
1569:
1224:
4357:
3954:
3239:
3222:
3191:
2983:
2928:
2755:
2666:
2635:
2183:
1964:, Bethesda (MD): National Institute of Child Health and Human Development, 2006,
1117:
1073:
pumps is slowed in patients taking strong p-glycoprotein pump inhibitors such as
1065:
869:
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312:
2750:
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and in those with a history of prior clots. It is used as an alternative to
4265:
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4181:
4130:
4109:
3959:
3898:
3854:
3731:
3674:
3613:
3608:
3589:
3487:
3456:
3358:
3323:
3248:
3199:
3121:"FDA approves Pradaxa to prevent stroke in people with atrial fibrillation"
3076:
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2900:
2865:
2804:
2704:
2643:
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2551:
2515:
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2362:
2313:
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2242:
2191:
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2110:
2069:
2015:
1969:
1913:
1830:
1782:
1773:
1745:
1696:
1546:
World Health Organization model list of essential medicines: 21st list 2019
1492:
1165:
1053:
1006:
877:
211:
33:
3009:
2497:
2389:
2137:
1904:
1887:
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2050:
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1021:
964:
928:
873:
90:
3018:
2398:
2146:
1554:
1142:(EMA) granted marketing authorization for Pradaxa for the prevention of
1048:. Furthermore, dabigatran can inactivate thrombin even when thrombin is
858:
456:
448:
4240:
4157:
4140:
4125:
4104:
4084:
4027:
4012:
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3825:
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3726:
3706:
3684:
3573:
3557:
3553:
3502:
2946:"Approval of new drug heralds 'momentous' advance in stroke prevention"
2447:
2007:
1082:
1020:
Dabigatran intake has also been reported to cause esophageal injury or
698:
467:
191:
41:
3350:
3314:
3297:
2696:
2305:
752:
CN1C=2C(=CC(C(N(CCC(O)=O)C3=CC=CC=N3)=O)=CC2)N=C1CNC4=CC=C(C(=N)N)C=C4
4228:
4223:
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3762:
3736:
3701:
3689:
3651:
3646:
3636:
3598:
3568:
3563:
3541:
3507:
3482:
1888:"Dabigatran versus warfarin in patients with mechanical heart valves"
1822:
1727:
1465:
Romanelli RJ, Nolting L, Dolginsky M, Kym E, Orrico KB (March 2016).
1078:
1074:
993:
881:
876:. In cases of severe bleeding, it can be reversed with the antidote,
865:
378:
76:
1202:
In July 2014, a series of investigations accused the privately held
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1709:
1109:
1041:
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135:
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and hexyloxycarbonyl carbamide hydrophobic side chains led to the
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920:
838:
572:
122:
3298:"Dabigatran: how the drug company withheld important analyses"
3517:
2621:
1444:(76 ed.). Pharmaceutical Press. 2018. pp. 135â137.
1125:
712:
544:
1517:
Oral Anticoagulation Therapy: Cases and Clinical Correlation
1464:
1172:
for intravenous administration, was developed, and received
633:
4162:
2528:
2334:
1409:"Dabigatran Etexilate Mesylate Monograph for Professionals"
845:. Specifically it is used to prevent blood clots following
516:
2572:
1088:
Dabigatran is available as dabigatran etexilate mesilate,
3220:
2291:
1540:
1558:. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
3176:
901:
World Health Organization's List of Essential Medicines
1040:
Dabigatran reversibly binds to the active site on the
4341:
1044:
molecule, preventing thrombin-mediated activation of
1013:
it does, then the associated risk is relatively low.
1009:
for dabigatran, and emergency endoscopic management.
3091:"Boehringer wins first US OK in blood-thinner race"
2682:
2660:"Pradaxa Summary of Product Characteristics" (2018)
2255:
1934:. U.S. Food and Drug Administration. 21 June 2019.
1318:
1316:
1314:
1312:
1310:
1308:
1306:
1179:Pradaxa received a Notice of Compliance (NOC) from
1052:-bound; it reduces thrombin-mediated inhibition of
427:
419:
3336:
3143:
1807:
1785:. Report No.: 18-EHC018-EFReport No.: 2018-SR-04.
1217:
1146:following hip or knee replacement surgery and for
972:) and major bleeding when compared with warfarin.
1415:. American Society of Health-System Pharmacists.
907:million prescriptions. Dabigatran is available a
4365:
3382:"$ 650 Million to Settle Blood Thinner Lawsuits"
3330:
3051:"New oral anticoagulants in atrial fibrillation"
2031:
2027:
2025:
1471:Circulation: Cardiovascular Quality and Outcomes
1324:"Pradaxa- dabigatran etexilate mesylate capsule"
1303:
399:
391:
3141:
2082:
1765:Agency for Healthcare Research and Quality (US)
366:
358:
2215:
2213:
2168:
1993:
4429:World Health Organization essential medicines
3425:
2486:Medicina Oral, Patologia Oral Y Cirugia Bucal
2032:Lin S, Wang Y, Zhang L, Guan W (6 May 2019).
2022:
3214:
3170:
3145:"New Blood-Thinner Recommended by FDA Panel"
2428:
1600:"Office of Generic Drugs 2020 Annual Report"
1085:, thus raising plasma levels of dabigatran.
139:
2655:
2653:
2210:
1403:
1401:
1399:
1346:
1281:"Summary of Product Characteristics (SmPC)"
1225:"Dabigatran (Pradaxa) Use During Pregnancy"
3432:
3418:
2823:
2775:
2294:Journal of Gastroenterology and Hepatology
2076:
1996:American Journal of Health-System Pharmacy
1397:
1395:
1393:
1391:
1389:
1387:
1385:
1383:
1381:
1379:
1056:and, therefore, may enhance fibrinolysis.
647:
483:
475:
3313:
3238:
3066:
3017:
2922:"Summary Basis of Decision (SBD): Pradax"
2855:
2598:
2505:
2456:
2446:
2397:
2352:
2145:
2100:
2059:
2049:
1903:
1772:
1735:
1686:
1676:
1553:
1482:
864:Common side effects include bleeding and
504:
2989:
2881:American Journal of Cardiovascular Drugs
2650:
2435:AJNR. American Journal of Neuroradiology
2341:Clinical Gastroenterology and Hepatology
1442:British national formulary : BNF 76
4394:Drugs developed by Boehringer Ingelheim
1962:Drugs and Lactation Database (LactMedÂź)
1932:Center for Drug Evaluation and Research
1534:
1436:
1434:
1376:
643:
455:
447:
95:
14:
4366:
3379:
3127:(FDA). 19 October 2010. Archived from
3048:
2943:
2829:
1035:
291:
266:
113:
3413:
3295:
3277:from the original on 11 November 2020
3142:Shirley S. Wang (20 September 2010).
2083:Uchino K, Hernandez AV (March 2012).
1938:from the original on 27 February 2023
1614:from the original on 12 February 2021
1580:from the original on 13 November 2022
1548:. Geneva: World Health Organization.
1513:
609:
588:
580:
560:
552:
279:
130:
81:
2986:Medical News Today. 28 October 2010.
2878:
2763:from the original on 15 January 2009
2743:
2038:Drug Design, Development and Therapy
1867:from the original on 2 November 2014
1570:"Dabigatran - Drug Usage Statistics"
1431:
1135:, BIBR 1048 (dabigatran etexilate).
957:
888:. Compared to warfarin it has fewer
615:
215:
3113:
3083:
2998:The New England Journal of Medicine
2378:The New England Journal of Medicine
2172:International Journal of Cardiology
2126:The New England Journal of Medicine
1892:The New England Journal of Medicine
1235:from the original on 1 October 2020
1059:
890:interactions with other medications
532:
524:
382:
24:
3158:from the original on 24 April 2016
2751:"Clot drug 'could save thousands'"
2429:Comin J, Kallmes DF (March 2012).
1789:from the original on 29 March 2019
1419:from the original on 27 March 2019
1291:from the original on 21 April 2023
1120:, specifically thrombin, but also
986:
25:
4440:
3394:from the original on 11 June 2021
2235:10.1161/circulationaha.113.003628
1334:from the original on 28 June 2021
946:It appears to be as effective as
868:. Other side effects may include
242:
162:
4351:
4047:Direct thrombin (IIa) inhibitors
3475:Glycoprotein IIb/IIIa inhibitors
2624:American Journal of Therapeutics
2532:Journal of Clinical Pharmacology
1364:from the original on 5 June 2023
1148:non-valvular atrial fibrillation
880:. Use is not recommended during
682:
676:
59:Pradaxa, Pradax, Prazaxa, others
40:
3670:Thromboxane synthase inhibitors
3373:
3289:
3255:
3135:
3101:from the original on 4 May 2016
3042:
2970:
2937:
2915:
2872:
2711:
2676:
2615:
2566:
2522:
2473:
2422:
2369:
2328:
2285:
2271:10.1016/j.clinthera.2023.05.007
2249:
2198:
2162:
2117:
2102:10.1001/archinternmed.2011.1666
1987:
1976:from the original on 2 May 2023
1950:
1920:
1879:
1845:
1801:
1752:
1703:
1652:
1626:
1592:
1562:
1484:10.1161/CIRCOUTCOMES.115.002369
1030:
914:
872:and allergic reactions such as
794:Key:KSGXQBZTULBEEQ-UHFFFAOYSA-N
783:Key:YBSJFWOBGCMAKL-UHFFFAOYSA-N
2685:Journal of Medicinal Chemistry
1507:
1458:
1273:
1247:
919:Dabigatran is used to prevent
688:
670:
255:
13:
1:
2836:Journal of Clinical Pathology
2089:Archives of Internal Medicine
1634:"Dabigatran Etexilate Accord"
1255:"Pradaxa Product information"
1210:
3908:Low-molecular-weight heparin
3719:Phosphodiesterase inhibitors
3632:Acetylsalicylic acid/Aspirin
3269:Food and Drug Administration
3240:10.1161/CIR.0b013e31820f14c0
3192:10.1097/SLA.0b013e3181ae6dbe
3125:Food and Drug Administration
2944:Kirkey S (29 October 2010).
2636:10.1097/mjt.0000000000000599
2184:10.1016/j.ijcard.2018.05.048
1859:Food and Drug Administration
1606:Food and Drug Administration
1189:Food and Drug Administration
1174:Food and Drug Administration
941:low molecular weight heparin
825:, sold under the brand name
7:
2830:Hanley JP (November 2004).
1811:Annals of Internal Medicine
1716:Annals of Internal Medicine
10:
4445:
4409:Direct thrombin inhibitors
3049:Turpie AG (January 2008).
2785:Thrombosis and Haemostasis
2221:Therapy) trial analysis".
1767:(Report). Rockville (MD).
1099:
833:used to treat and prevent
660:Chemical and physical data
4302:
4274:
4175:
4118:
4045:
3997:
3886:
3880:(with some II inhibition)
3874:
3784:
3775:
3745:
3717:
3660:
3622:
3584:
3516:
3473:
3464:
2893:10.1007/s40256-016-0181-4
2724:European Medicines Agency
2671:European Medicines Agency
2591:10.1016/j.joa.2017.07.013
2354:10.1016/j.cgh.2012.10.021
1638:European Medicines Agency
1542:World Health Organization
1358:European Medicines Agency
1259:health-products.canada.ca
1140:European Medicines Agency
894:direct thrombin inhibitor
870:bleeding around the spine
802:
766:
740:
710:
697:
664:
659:
627:
599:
571:
543:
515:
494:
466:
438:
410:
377:
349:
344:
331:
321:
311:
303:
232:
227:
202:
197:Direct thrombin inhibitor
190:
176:
150:
103:
89:
71:
63:
53:
48:
39:
3380:Thomas K (28 May 2014).
3068:10.1093/eurheartj/ehm575
2544:10.1177/0091270005274550
1520:. Springer. p. 11.
1176:(FDA) approval in 2015.
27:Anticoagulant medication
3151:The Wall Street Journal
2848:10.1136/jcp.2003.008904
1155:National Health Service
4190:Plasminogen activators
3662:Thromboxane inhibitors
3586:Prostaglandin analogue
3123:(Press release). U.S.
3055:European Heart Journal
2431:"Dabigatran (Pradaxa)"
1774:10.23970/ahrqepccer214
1144:thromboembolic disease
1096:dabigatran etexilate.
4252:serine endopeptidases
3786:Vitamin K antagonists
3296:Cohen D (July 2014).
3010:10.1056/NEJMoa0905561
2982:24 April 2011 at the
2579:Journal of Arrhythmia
2498:10.4317/medoral.21202
2390:10.1056/NEJMoa0905561
2259:Clinical Therapeutics
2138:10.1056/NEJMoa0905561
1905:10.1056/NEJMoa1300615
1287:. 15 September 2022.
1000:receptor inhibitor (H
970:myocardial infarction
3999:Direct Xa inhibitors
3831:Ethyl biscoumacetate
3697:Receptor antagonists
2927:14 July 2016 at the
2797:10.1160/TH09-11-0758
2051:10.2147/DDDT.S203112
1231:. 27 December 2018.
1204:Boehringer Ingelheim
1124:. Addition of ethyl
933:deep vein thrombosis
829:among others, is an
4424:2-Pyridyl compounds
3642:Carbasalate calcium
3131:on 20 October 2010.
3097:. 19 October 2010.
2832:"Warfarin reversal"
2665:5 July 2019 at the
1678:10.1155/2013/640723
1170:monoclonal antibody
1138:In March 2008, the
1112:inhibitor α-NAPAP (
1046:coagulation factors
1036:Mechanism of action
931:issues, as well as
925:atrial fibrillation
843:atrial fibrillation
728:as etexilate:
587:as etexilate:
559:as etexilate:
531:as etexilate:
503:as etexilate:
482:as etexilate:
454:as etexilate:
426:as etexilate:
398:as etexilate:
365:as etexilate:
275:(Prescription only)
251:(Prescription only)
67:BIBR-953, BIBR-1048
36:
4329:Never to phase III
4177:Thrombolytic drugs
3893:glycosaminoglycans
3466:Antiplatelet drugs
3453:antiplatelet drugs
3387:The New York Times
2934:. 6 November 2008.
2448:10.3174/ajnr.A3000
2008:10.2146/ajhp100348
937:pulmonary embolism
909:generic medication
32:
4419:Propionate esters
4339:
4338:
4171:
4170:
4041:
4040:
3771:
3770:
3351:10.1136/bmj.g4517
3315:10.1136/bmj.g4670
3233:(10): 1144â1150.
3180:Annals of Surgery
3004:(12): 1139â1151.
2842:(11): 1132â1139.
2759:. 20 April 2008.
2697:10.1021/jm0109513
2384:(12): 1139â1151.
2347:(3): 246â252.e5.
2306:10.1111/jgh.13024
2132:(12): 1139â1151.
2002:(16): 1506â1519.
1898:(13): 1206â1214.
1817:(11): 1515â1524.
1360:. 22 March 2023.
1261:. 22 October 2009
963:dabigatran (e.g.
958:Contraindications
820:
819:
731:Interactive image
723:Interactive image
629:CompTox Dashboard
295:
283:
270:
258:
246:
166:
133:
116:
16:(Redirected from
4436:
4356:
4355:
4354:
4347:
4151:Drotrecogin alfa
4131:Antithrombin III
3982:Dermatan sulfate
3955:Oligosaccharides
3884:
3883:
3782:
3781:
3518:ADP receptor/P2Y
3471:
3470:
3434:
3427:
3420:
3411:
3410:
3404:
3403:
3401:
3399:
3377:
3371:
3370:
3334:
3328:
3327:
3317:
3293:
3287:
3286:
3284:
3282:
3273:. 21 June 2019.
3259:
3253:
3252:
3242:
3218:
3212:
3211:
3174:
3168:
3167:
3165:
3163:
3147:
3139:
3133:
3132:
3117:
3111:
3110:
3108:
3106:
3087:
3081:
3080:
3070:
3046:
3040:
3039:
3021:
2993:
2987:
2974:
2968:
2967:
2965:
2963:
2954:. Archived from
2951:Montreal Gazette
2941:
2935:
2919:
2913:
2912:
2876:
2870:
2869:
2859:
2827:
2821:
2820:
2791:(6): 1116â1127.
2779:
2773:
2772:
2770:
2768:
2747:
2741:
2740:
2738:
2736:
2731:on 2 August 2012
2727:. Archived from
2715:
2709:
2708:
2691:(9): 1757â1766.
2680:
2674:
2657:
2648:
2647:
2630:(3): e308âe313.
2619:
2613:
2612:
2602:
2570:
2564:
2563:
2526:
2520:
2519:
2509:
2492:(6): e679âe688.
2477:
2471:
2470:
2460:
2450:
2426:
2420:
2419:
2401:
2373:
2367:
2366:
2356:
2332:
2326:
2325:
2289:
2283:
2282:
2265:(7): e151âe158.
2253:
2247:
2246:
2217:
2208:
2202:
2196:
2195:
2166:
2160:
2159:
2149:
2121:
2115:
2114:
2104:
2080:
2074:
2073:
2063:
2053:
2029:
2020:
2019:
1991:
1985:
1984:
1983:
1981:
1954:
1948:
1947:
1945:
1943:
1924:
1918:
1917:
1907:
1883:
1877:
1876:
1874:
1872:
1849:
1843:
1842:
1823:10.7326/M22-0511
1805:
1799:
1798:
1796:
1794:
1776:
1756:
1750:
1749:
1739:
1728:10.7326/M18-1523
1707:
1701:
1700:
1690:
1680:
1656:
1650:
1649:
1647:
1645:
1630:
1624:
1623:
1621:
1619:
1596:
1590:
1589:
1587:
1585:
1566:
1560:
1559:
1557:
1538:
1532:
1531:
1514:Kiser K (2017).
1511:
1505:
1504:
1486:
1462:
1456:
1455:
1438:
1429:
1428:
1426:
1424:
1405:
1374:
1373:
1371:
1369:
1350:
1344:
1343:
1341:
1339:
1320:
1301:
1300:
1298:
1296:
1277:
1271:
1270:
1268:
1266:
1251:
1245:
1244:
1242:
1240:
1221:
1118:serine proteases
1060:Pharmacokinetics
906:
851:knee replacement
816:
815:
808:
733:
725:
705:
690:
684:
678:
672:
652:
651:
637:
635:
619:
613:
592:
584:
564:
556:
536:
528:
508:
487:
479:
459:
451:
431:
423:
403:
395:
385:
384:
370:
362:
336:
293:
290:
281:
278:
268:
265:
257:
254:
244:
241:
219:
164:
161:
143:
132:
129:
126:
115:
112:
99:
85:
44:
37:
35:
31:
21:
4444:
4443:
4439:
4438:
4437:
4435:
4434:
4433:
4384:Aromatic amines
4364:
4363:
4362:
4352:
4350:
4342:
4340:
4335:
4334:
4319:Clinical trials
4298:
4270:
4180:
4167:
4114:
4037:
3993:
3896:
3891:
3879:
3870:
3846:1,3-Indandiones
3788:
3767:
3741:
3713:
3656:
3618:
3580:
3532:Thienopyridines
3521:
3512:
3460:
3441:Antithrombotics
3438:
3408:
3407:
3397:
3395:
3378:
3374:
3335:
3331:
3294:
3290:
3280:
3278:
3261:
3260:
3256:
3219:
3215:
3175:
3171:
3161:
3159:
3140:
3136:
3119:
3118:
3114:
3104:
3102:
3089:
3088:
3084:
3047:
3043:
2994:
2990:
2984:Wayback Machine
2975:
2971:
2961:
2959:
2958:on 16 June 2011
2942:
2938:
2929:Wayback Machine
2920:
2916:
2877:
2873:
2828:
2824:
2780:
2776:
2766:
2764:
2756:BBC News Online
2749:
2748:
2744:
2734:
2732:
2717:
2716:
2712:
2681:
2677:
2667:Wayback Machine
2658:
2651:
2620:
2616:
2571:
2567:
2527:
2523:
2478:
2474:
2427:
2423:
2374:
2370:
2333:
2329:
2290:
2286:
2254:
2250:
2218:
2211:
2203:
2199:
2167:
2163:
2122:
2118:
2081:
2077:
2030:
2023:
1992:
1988:
1979:
1977:
1956:
1955:
1951:
1941:
1939:
1926:
1925:
1921:
1884:
1880:
1870:
1868:
1851:
1850:
1846:
1806:
1802:
1792:
1790:
1757:
1753:
1722:(11): 774â787.
1708:
1704:
1657:
1653:
1643:
1641:
1632:
1631:
1627:
1617:
1615:
1598:
1597:
1593:
1583:
1581:
1568:
1567:
1563:
1539:
1535:
1528:
1512:
1508:
1463:
1459:
1452:
1440:
1439:
1432:
1422:
1420:
1407:
1406:
1377:
1367:
1365:
1352:
1351:
1347:
1337:
1335:
1330:. 6 July 2020.
1322:
1321:
1304:
1294:
1292:
1279:
1278:
1274:
1264:
1262:
1253:
1252:
1248:
1238:
1236:
1223:
1222:
1218:
1213:
1130:orally absorbed
1102:
1066:bioavailability
1062:
1038:
1033:
1003:
999:
989:
987:Adverse effects
960:
917:
904:
859:ischemic stroke
841:in people with
837:and to prevent
811:
809:
806:(what is this?)
803:
798:
795:
790:
787:
784:
779:
774:
773:
762:
759:
756:
753:
748:
747:
736:
703:
693:
687:
681:
675:
655:
631:
623:
595:
567:
539:
511:
490:
462:
434:
406:
381:
373:
334:
323:Protein binding
313:Bioavailability
305:Pharmacokinetic
299:
223:
179:
172:
153:
146:
28:
23:
22:
15:
12:
11:
5:
4442:
4432:
4431:
4426:
4421:
4416:
4411:
4406:
4401:
4396:
4391:
4389:Benzimidazoles
4386:
4381:
4376:
4361:
4360:
4337:
4336:
4333:
4332:
4331:
4330:
4327:
4316:
4310:
4304:
4303:
4300:
4299:
4297:
4296:
4291:
4286:
4280:
4278:
4272:
4271:
4269:
4268:
4263:
4258:
4248:
4243:
4238:
4233:
4232:
4231:
4226:
4218:
4217:
4216:
4211:
4206:
4201:
4186:
4184:
4173:
4172:
4169:
4168:
4166:
4165:
4160:
4155:
4154:
4153:
4143:
4138:
4133:
4128:
4122:
4120:
4116:
4115:
4113:
4112:
4107:
4102:
4097:
4092:
4087:
4078:
4077:
4076:
4071:
4066:
4051:
4049:
4043:
4042:
4039:
4038:
4036:
4035:
4030:
4025:
4020:
4015:
4010:
4004:
4002:
3995:
3994:
3992:
3991:
3990:
3989:
3984:
3979:
3969:
3968:
3967:
3962:
3952:
3951:
3950:
3945:
3940:
3935:
3930:
3925:
3920:
3915:
3904:
3902:
3881:
3872:
3871:
3869:
3868:
3862:
3857:
3852:
3843:
3838:
3833:
3828:
3823:
3818:
3808:
3806:
3779:
3777:Anticoagulants
3773:
3772:
3769:
3768:
3766:
3765:
3760:
3755:
3749:
3747:
3743:
3742:
3740:
3739:
3734:
3729:
3723:
3721:
3715:
3714:
3712:
3711:
3710:
3709:
3704:
3694:
3693:
3692:
3687:
3682:
3666:
3664:
3658:
3657:
3655:
3654:
3649:
3644:
3639:
3634:
3628:
3626:
3624:COX inhibitors
3620:
3619:
3617:
3616:
3611:
3606:
3601:
3595:
3593:
3582:
3581:
3579:
3578:
3577:
3576:
3571:
3566:
3551:
3550:
3549:
3544:
3539:
3528:
3526:
3519:
3514:
3513:
3511:
3510:
3505:
3500:
3495:
3490:
3485:
3479:
3477:
3468:
3462:
3461:
3449:anticoagulants
3437:
3436:
3429:
3422:
3414:
3406:
3405:
3372:
3329:
3288:
3254:
3213:
3186:(2): 219â228.
3169:
3134:
3112:
3082:
3061:(2): 155â165.
3041:
2988:
2969:
2936:
2914:
2887:(4): 297â304.
2871:
2822:
2774:
2742:
2719:"Pradaxa EPAR"
2710:
2675:
2649:
2614:
2585:(6): 619â623.
2565:
2538:(5): 555â563.
2521:
2472:
2441:(3): 426â428.
2421:
2368:
2327:
2300:(3): 610â614.
2284:
2248:
2229:(9): 961â970.
2209:
2197:
2161:
2116:
2095:(5): 397â402.
2075:
2021:
1986:
1949:
1919:
1878:
1844:
1800:
1751:
1702:
1651:
1625:
1591:
1561:
1533:
1526:
1506:
1477:(2): 126â134.
1457:
1450:
1430:
1375:
1354:"Pradaxa EPAR"
1345:
1302:
1272:
1246:
1215:
1214:
1212:
1209:
1168:, a humanized
1159:anticoagulants
1101:
1098:
1071:P-glycoprotein
1061:
1058:
1037:
1034:
1032:
1029:
1001:
997:
988:
985:
959:
956:
927:not caused by
923:in those with
916:
913:
818:
817:
800:
799:
797:
796:
793:
791:
788:
785:
782:
780:
777:
769:
768:
767:
764:
763:
761:
760:
757:
754:
751:
743:
742:
741:
738:
737:
735:
734:
726:
718:
716:
708:
707:
701:
695:
694:
691:
685:
679:
673:
668:
662:
661:
657:
656:
654:
653:
645:DTXSID50175419
640:
638:
625:
624:
622:
621:
605:
603:
597:
596:
594:
593:
585:
577:
575:
569:
568:
566:
565:
557:
549:
547:
541:
540:
538:
537:
529:
521:
519:
513:
512:
510:
509:
500:
498:
492:
491:
489:
488:
480:
472:
470:
464:
463:
461:
460:
452:
444:
442:
436:
435:
433:
432:
424:
416:
414:
408:
407:
405:
404:
396:
388:
386:
375:
374:
372:
371:
363:
355:
353:
347:
346:
342:
341:
338:
329:
328:
325:
319:
318:
315:
309:
308:
301:
300:
298:
297:
288:
276:
263:
252:
238:
236:
230:
229:
225:
224:
222:
221:
208:
206:
200:
199:
194:
188:
187:
182:
180:administration
174:
173:
171:
170:
168:
158:
156:
148:
147:
145:
144:
127:
109:
107:
101:
100:
93:
87:
86:
79:
69:
68:
65:
61:
60:
57:
51:
50:
46:
45:
26:
9:
6:
4:
3:
2:
4441:
4430:
4427:
4425:
4422:
4420:
4417:
4415:
4412:
4410:
4407:
4405:
4402:
4400:
4397:
4395:
4392:
4390:
4387:
4385:
4382:
4380:
4377:
4375:
4372:
4371:
4369:
4359:
4349:
4348:
4345:
4328:
4326:
4323:
4322:
4320:
4317:
4314:
4311:
4309:
4306:
4305:
4301:
4295:
4292:
4290:
4287:
4285:
4282:
4281:
4279:
4277:
4276:Non-medicinal
4273:
4267:
4264:
4262:
4259:
4257:
4253:
4249:
4247:
4246:Streptokinase
4244:
4242:
4239:
4237:
4234:
4230:
4227:
4225:
4222:
4221:
4219:
4215:
4212:
4210:
4207:
4205:
4202:
4200:
4197:
4196:
4195:
4191:
4188:
4187:
4185:
4183:
4182:fibrinolytics
4178:
4174:
4164:
4161:
4159:
4156:
4152:
4149:
4148:
4147:
4144:
4142:
4139:
4137:
4134:
4132:
4129:
4127:
4124:
4123:
4121:
4117:
4111:
4108:
4106:
4103:
4101:
4098:
4096:
4093:
4091:
4088:
4086:
4082:
4079:
4075:
4072:
4070:
4067:
4065:
4062:
4061:
4060:
4056:
4053:
4052:
4050:
4048:
4044:
4034:
4031:
4029:
4026:
4024:
4021:
4019:
4016:
4014:
4011:
4009:
4006:
4005:
4003:
4000:
3996:
3988:
3985:
3983:
3980:
3978:
3975:
3974:
3973:
3970:
3966:
3963:
3961:
3958:
3957:
3956:
3953:
3949:
3946:
3944:
3941:
3939:
3936:
3934:
3931:
3929:
3926:
3924:
3921:
3919:
3916:
3914:
3911:
3910:
3909:
3906:
3905:
3903:
3900:
3894:
3889:
3885:
3882:
3877:
3873:
3867:
3863:
3861:
3858:
3856:
3853:
3851:
3847:
3844:
3842:
3839:
3837:
3836:Phenprocoumon
3834:
3832:
3829:
3827:
3824:
3822:
3821:Coumatetralyl
3819:
3817:
3816:Acenocoumarol
3813:
3810:
3809:
3807:
3804:
3800:
3796:
3792:
3787:
3783:
3780:
3778:
3774:
3764:
3761:
3759:
3756:
3754:
3751:
3750:
3748:
3744:
3738:
3735:
3733:
3730:
3728:
3725:
3724:
3722:
3720:
3716:
3708:
3705:
3703:
3700:
3699:
3698:
3695:
3691:
3688:
3686:
3683:
3680:
3676:
3673:
3672:
3671:
3668:
3667:
3665:
3663:
3659:
3653:
3650:
3648:
3645:
3643:
3640:
3638:
3635:
3633:
3630:
3629:
3627:
3625:
3621:
3615:
3612:
3610:
3607:
3605:
3602:
3600:
3597:
3596:
3594:
3591:
3587:
3583:
3575:
3572:
3570:
3567:
3565:
3562:
3561:
3559:
3555:
3552:
3548:
3545:
3543:
3540:
3538:
3535:
3534:
3533:
3530:
3529:
3527:
3525:
3522:
3515:
3509:
3506:
3504:
3501:
3499:
3496:
3494:
3491:
3489:
3486:
3484:
3481:
3480:
3478:
3476:
3472:
3469:
3467:
3463:
3458:
3454:
3450:
3446:
3445:thrombolytics
3442:
3435:
3430:
3428:
3423:
3421:
3416:
3415:
3412:
3393:
3389:
3388:
3383:
3376:
3368:
3364:
3360:
3356:
3352:
3348:
3344:
3340:
3333:
3325:
3321:
3316:
3311:
3307:
3303:
3299:
3292:
3276:
3272:
3270:
3264:
3258:
3250:
3246:
3241:
3236:
3232:
3228:
3224:
3217:
3209:
3205:
3201:
3197:
3193:
3189:
3185:
3181:
3173:
3157:
3153:
3152:
3146:
3138:
3130:
3126:
3122:
3116:
3100:
3096:
3092:
3086:
3078:
3074:
3069:
3064:
3060:
3056:
3052:
3045:
3037:
3033:
3029:
3025:
3020:
3015:
3011:
3007:
3003:
2999:
2992:
2985:
2981:
2978:
2973:
2957:
2953:
2952:
2947:
2940:
2933:
2932:Health Canada
2930:
2926:
2923:
2918:
2910:
2906:
2902:
2898:
2894:
2890:
2886:
2882:
2875:
2867:
2863:
2858:
2853:
2849:
2845:
2841:
2837:
2833:
2826:
2819:
2814:
2810:
2806:
2802:
2798:
2794:
2790:
2786:
2778:
2762:
2758:
2757:
2752:
2746:
2730:
2726:
2725:
2720:
2714:
2706:
2702:
2698:
2694:
2690:
2686:
2679:
2672:
2668:
2664:
2661:
2656:
2654:
2645:
2641:
2637:
2633:
2629:
2625:
2618:
2610:
2606:
2601:
2596:
2592:
2588:
2584:
2580:
2576:
2569:
2561:
2557:
2553:
2549:
2545:
2541:
2537:
2533:
2525:
2517:
2513:
2508:
2503:
2499:
2495:
2491:
2487:
2483:
2476:
2468:
2464:
2459:
2454:
2449:
2444:
2440:
2436:
2432:
2425:
2417:
2413:
2409:
2405:
2400:
2395:
2391:
2387:
2383:
2379:
2372:
2364:
2360:
2355:
2350:
2346:
2342:
2338:
2331:
2323:
2319:
2315:
2311:
2307:
2303:
2299:
2295:
2288:
2280:
2276:
2272:
2268:
2264:
2260:
2252:
2244:
2240:
2236:
2232:
2228:
2224:
2216:
2214:
2207:
2201:
2193:
2189:
2185:
2181:
2177:
2173:
2165:
2157:
2153:
2148:
2143:
2139:
2135:
2131:
2127:
2120:
2112:
2108:
2103:
2098:
2094:
2090:
2086:
2079:
2071:
2067:
2062:
2057:
2052:
2047:
2044:: 1527â1533.
2043:
2039:
2035:
2028:
2026:
2017:
2013:
2009:
2005:
2001:
1997:
1990:
1975:
1971:
1967:
1963:
1959:
1953:
1937:
1933:
1929:
1923:
1915:
1911:
1906:
1901:
1897:
1893:
1889:
1882:
1866:
1862:
1860:
1854:
1848:
1840:
1836:
1832:
1828:
1824:
1820:
1816:
1812:
1804:
1788:
1784:
1780:
1775:
1770:
1766:
1762:
1755:
1747:
1743:
1738:
1733:
1729:
1725:
1721:
1717:
1713:
1706:
1698:
1694:
1689:
1684:
1679:
1674:
1670:
1666:
1662:
1655:
1640:. 31 May 2023
1639:
1635:
1629:
1613:
1609:
1607:
1601:
1595:
1579:
1575:
1571:
1565:
1556:
1551:
1547:
1543:
1537:
1529:
1527:9783319546438
1523:
1519:
1518:
1510:
1502:
1498:
1494:
1490:
1485:
1480:
1476:
1472:
1468:
1461:
1453:
1451:9780857113382
1447:
1443:
1437:
1435:
1418:
1414:
1410:
1404:
1402:
1400:
1398:
1396:
1394:
1392:
1390:
1388:
1386:
1384:
1382:
1380:
1363:
1359:
1355:
1349:
1333:
1329:
1325:
1319:
1317:
1315:
1313:
1311:
1309:
1307:
1290:
1286:
1282:
1276:
1260:
1256:
1250:
1234:
1230:
1226:
1220:
1216:
1208:
1205:
1200:
1196:
1192:
1190:
1185:
1182:
1181:Health Canada
1177:
1175:
1171:
1167:
1162:
1160:
1156:
1151:
1149:
1145:
1141:
1136:
1134:
1131:
1127:
1123:
1119:
1115:
1111:
1107:
1097:
1095:
1091:
1086:
1084:
1080:
1076:
1072:
1067:
1057:
1055:
1051:
1047:
1043:
1028:
1025:
1023:
1018:
1014:
1010:
1008:
995:
984:
981:
978:
973:
971:
966:
955:
951:
949:
944:
942:
938:
934:
930:
926:
922:
912:
910:
902:
897:
895:
891:
887:
886:breastfeeding
883:
879:
875:
871:
867:
862:
860:
856:
852:
848:
844:
840:
836:
832:
831:anticoagulant
828:
824:
814:
807:
801:
792:
786:
781:
776:
775:
772:
765:
755:
750:
749:
746:
739:
732:
727:
724:
720:
719:
717:
714:
709:
702:
700:
696:
669:
667:
663:
658:
650:
646:
642:
641:
639:
630:
626:
618:
617:RCSB PDB
612:
607:
606:
604:
602:
598:
591:
586:
583:
579:
578:
576:
574:
570:
563:
558:
555:
551:
550:
548:
546:
542:
535:
530:
527:
523:
522:
520:
518:
514:
507:
502:
501:
499:
497:
493:
486:
481:
478:
474:
473:
471:
469:
465:
458:
453:
450:
446:
445:
443:
441:
437:
430:
425:
422:
418:
417:
415:
413:
409:
402:
397:
394:
390:
389:
387:
380:
376:
369:
364:
361:
357:
356:
354:
352:
348:
343:
339:
337:
330:
326:
324:
320:
316:
314:
310:
306:
302:
296: Rx-only
289:
287:
277:
274:
264:
262:
253:
250:
240:
239:
237:
235:
231:
226:
218:
213:
210:
209:
207:
205:
201:
198:
195:
193:
189:
186:
183:
181:
175:
169:
160:
159:
157:
155:
149:
142:
137:
128:
125:
120:
111:
110:
108:
106:
102:
98:
94:
92:
88:
84:
80:
78:
74:
70:
66:
62:
58:
56:
52:
49:Clinical data
47:
43:
38:
30:
19:
4414:Ethyl esters
4404:Carboxamides
4266:Fibrinolysin
4236:Anistreplase
4214:Desmoteplase
4209:Tenecteplase
4110:Ximelagatran
4089:
3960:Fondaparinux
3899:antithrombin
3855:Diphenadione
3732:Dipyridamole
3675:Dipyridamole
3614:Treprostinil
3609:Prostacyclin
3488:Eptifibatide
3396:. Retrieved
3385:
3375:
3342:
3338:
3332:
3305:
3301:
3291:
3279:. Retrieved
3266:
3257:
3230:
3226:
3216:
3183:
3179:
3172:
3160:. Retrieved
3149:
3137:
3129:the original
3115:
3103:. Retrieved
3085:
3058:
3054:
3044:
3019:11343/221723
3001:
2997:
2991:
2972:
2960:. Retrieved
2956:the original
2949:
2939:
2917:
2884:
2880:
2874:
2839:
2835:
2825:
2816:
2788:
2784:
2777:
2765:. Retrieved
2754:
2745:
2733:. Retrieved
2729:the original
2722:
2713:
2688:
2684:
2678:
2627:
2623:
2617:
2582:
2578:
2568:
2535:
2531:
2524:
2489:
2485:
2475:
2438:
2434:
2424:
2399:11343/221723
2381:
2377:
2371:
2344:
2340:
2330:
2297:
2293:
2287:
2262:
2258:
2251:
2226:
2222:
2204:
2200:
2175:
2171:
2164:
2147:11343/221723
2129:
2125:
2119:
2092:
2088:
2078:
2041:
2037:
1999:
1995:
1989:
1978:, retrieved
1961:
1958:"Dabigatran"
1952:
1940:. Retrieved
1931:
1922:
1895:
1891:
1881:
1869:. Retrieved
1856:
1847:
1814:
1810:
1803:
1791:. Retrieved
1764:
1754:
1719:
1715:
1705:
1668:
1664:
1654:
1642:. Retrieved
1637:
1628:
1616:. Retrieved
1603:
1594:
1582:. Retrieved
1573:
1564:
1555:10665/325771
1545:
1536:
1516:
1509:
1474:
1470:
1460:
1441:
1421:. Retrieved
1412:
1366:. Retrieved
1357:
1348:
1336:. Retrieved
1327:
1293:. Retrieved
1284:
1275:
1263:. Retrieved
1258:
1249:
1237:. Retrieved
1228:
1219:
1201:
1197:
1193:
1186:
1178:
1166:idarucizumab
1163:
1152:
1137:
1113:
1103:
1087:
1063:
1054:fibrinolysis
1039:
1031:Pharmacology
1026:
1019:
1015:
1011:
1007:idarucizumab
990:
982:
974:
961:
952:
945:
918:
915:Medical uses
898:
878:idarucizumab
863:
826:
822:
821:
810:
804:
590:ChEMBL539697
333:Elimination
234:Legal status
228:Legal status
105:License data
29:
4315:from market
4136:Defibrotide
4064:Bivalirudin
4033:Rivaroxaban
3972:Heparinoids
3965:Idraparinux
3866:Tioclomarol
3860:Phenindione
3850:Clorindione
3753:Cloricromen
3547:Ticlopidine
3537:Clopidogrel
3398:26 November
3281:13 November
3227:Circulation
2223:Circulation
1980:27 February
1942:27 February
1618:12 February
1368:13 November
1338:13 November
1295:13 November
1265:13 November
1106:benzamidine
1022:esophagitis
965:anaphylaxis
929:heart valve
874:anaphylaxis
835:blood clots
706: g·mol
582:ChEMBL48361
562:CHEBI:70746
554:CHEBI:70752
368:211915-06-9
360:211914-51-1
345:Identifiers
340:12â17 hours
91:MedlinePlus
64:Other names
55:Trade names
4399:Carbamates
4368:Categories
4241:Monteplase
4158:Ramatroban
4141:Nafamostat
4126:Abelacimab
4105:Melagatran
4090:Dabigatran
4085:Argatroban
4028:Otamixaban
4013:Betrixaban
4001:("xabans")
3987:Sulodexide
3977:Danaparoid
3948:Tinzaparin
3938:Parnaparin
3933:Nadroparin
3928:Enoxaparin
3923:Dalteparin
3918:Certoparin
3878:inhibitors
3826:Dicoumarol
3727:Cilostazol
3707:Terutroban
3685:Picotamide
3574:Ticagrelor
3558:nucleoside
3554:Nucleotide
3524:inhibitors
3503:Sibrafiban
3162:20 October
3105:20 October
2962:29 October
2735:30 January
2206:49:259-68.
1871:29 October
1671:: 640723.
1665:Thrombosis
1211:References
1090:formulated
1083:amiodarone
892:. It is a
823:Dabigatran
711:3D model (
699:Molar mass
601:PDB ligand
506:2E18WX195X
468:ChemSpider
412:IUPHAR/BPS
351:CAS Number
192:Drug class
141:Dabigatran
34:Dabigatran
4325:Phase III
4313:Withdrawn
4229:Urokinase
4224:Saruplase
4204:Reteplase
4199:Alteplase
4146:Protein C
4100:Inogatran
4095:Efegatran
4081:Univalent
4074:Lepirudin
4069:Desirudin
4018:Darexaban
3943:Reviparin
3913:Bemiparin
3876:Factor Xa
3812:Coumarins
3789:(inhibit
3763:Vorapaxar
3737:Triflusal
3702:Terbogrel
3690:Terbogrel
3679:+ aspirin
3652:Triflusal
3647:Indobufen
3637:Aloxiprin
3599:Beraprost
3569:Elinogrel
3564:Cangrelor
3542:Prasugrel
3508:Tirofiban
3498:Roxifiban
3493:Orbofiban
3483:Abciximab
3345:: g4517.
3308:: g4670.
2818:activity.
1839:253238819
1584:7 October
1413:Drugs.com
1229:Drugs.com
1187:The U.S.
1079:verapamil
1075:quinidine
994:dyspepsia
882:pregnancy
866:gastritis
401:135565674
335:half-life
178:Routes of
152:Pregnancy
83:Monograph
77:Drugs.com
4379:Anilines
4374:Amidines
4358:Medicine
4055:Bivalent
4023:Edoxaban
4008:Apixaban
3841:Warfarin
3758:Ditazole
3604:Iloprost
3560:analogs
3392:Archived
3367:29090410
3359:25056265
3324:25055829
3275:Archived
3249:21321155
3208:44917732
3200:19638915
3156:Archived
3099:Archived
3077:18096568
3028:19717844
2980:Archived
2925:Archived
2909:11596083
2901:27388764
2866:15509671
2813:37404563
2805:20352166
2767:21 April
2761:Archived
2705:11960487
2663:Archived
2644:28452843
2609:29255511
2560:26441767
2552:15831779
2516:27694780
2467:22345499
2408:19717844
2363:23103906
2314:26102078
2279:37380555
2243:24323795
2192:29801762
2156:19717844
2111:22231617
2070:31190734
2016:21817082
1974:archived
1970:29999803
1936:Archived
1914:23991661
1865:Archived
1831:36315950
1787:Archived
1783:30480925
1746:30383133
1697:24455237
1612:Archived
1578:Archived
1574:ClinCalc
1544:(2019).
1493:26812933
1423:27 March
1417:Archived
1362:Archived
1332:Archived
1328:DailyMed
1289:Archived
1233:Archived
1110:thrombin
1042:thrombin
975:Current
948:warfarin
855:warfarin
813:(verify)
440:DrugBank
204:ATC code
185:By mouth
154:category
136:DailyMed
4294:Oxalate
4284:Citrate
4261:Brinase
4059:Hirudin
3888:Heparin
3864:Other:
3095:Reuters
3036:7425216
2857:1770479
2600:5729000
2507:5116109
2458:7966436
2416:7425216
2322:2601542
2178:: 1â7.
2061:6511609
1737:6825839
1688:3885278
1501:6840541
1133:prodrug
1122:trypsin
1108:-based
1100:History
1094:prodrug
1092:as the
921:strokes
827:Pradaxa
704:471.521
666:Formula
485:4948999
457:DB06695
449:DB14726
379:PubChem
259::
220:)
214: (
212:B01AE07
167: C
138::
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97:a610024
18:Pradaxa
4344:Portal
4308:WHO-EM
4256:Ancrod
4250:Other
3897:(bind
3890:group/
3365:
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1644:2 June
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1239:16 May
1081:, and
1050:fibrin
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839:stroke
745:SMILES
573:ChEMBL
534:D07144
526:D09707
477:187412
393:216210
286:â-only
284:
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261:â-only
247:
134:
124:by INN
117:
4194:r-tPA
4119:Other
3746:Other
3363:S2CID
3271:(FDA)
3267:U.S.
3204:S2CID
3032:S2CID
2905:S2CID
2809:S2CID
2556:S2CID
2412:S2CID
2318:S2CID
1861:(FDA)
1857:U.S.
1835:S2CID
1608:(FDA)
1604:U.S.
1497:S2CID
1285:(emc)
1126:ester
771:InChI
713:JSmol
608:4CC (
545:ChEBI
4289:EDTA
4220:UPA
4163:REG1
3590:PGI2
3451:and
3400:2020
3355:PMID
3320:PMID
3283:2020
3245:PMID
3196:PMID
3164:2010
3107:2010
3073:PMID
3024:PMID
2964:2010
2897:PMID
2862:PMID
2801:PMID
2769:2008
2737:2011
2701:PMID
2640:PMID
2605:PMID
2548:PMID
2512:PMID
2463:PMID
2404:PMID
2359:PMID
2310:PMID
2275:PMID
2239:PMID
2188:PMID
2152:PMID
2107:PMID
2066:PMID
2012:PMID
1982:2023
1966:PMID
1944:2023
1910:PMID
1873:2014
1827:PMID
1795:2023
1779:PMID
1742:PMID
1693:PMID
1669:2013
1646:2023
1620:2021
1586:2022
1522:ISBN
1489:PMID
1446:ISBN
1425:2019
1370:2023
1340:2020
1297:2023
1267:2023
1241:2020
1153:The
935:and
611:PDBe
517:KEGG
496:UNII
429:6379
421:6380
317:3â7%
307:data
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3795:VII
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3339:BMJ
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3302:BMJ
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3014:hdl
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2852:PMC
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2793:doi
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1815:175
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