1196:
found evidence that serum levels of dabigatran vary widely. The BMJ investigation suggested that
Boehringer had a financial motive to withhold this concern from regulatory health agencies because the data conflicted with their extensive marketing of dabigatran as an anticoagulant that does not require monitoring. In August 2012, Pradaxa claims filed in U.S. federal courts were consolidated into a multi-district litigation in the Southern District of Illinois before Chief Judge David R. Herndon. In May 2014, a $ 650 million settlement was announced on behalf of approximately 3,900 claimants who were injured by the drug Pradaxa made by Boehringer Ingelheim Pharmaceuticals, Inc. The drug was alleged to cause severe bleeding events and/or hemorrhaging to those who were taking the drug.
638:
31:
1013:. In a 2016 study by Toya et al., roughly 20% of patients suffered esophageal mucosa damage. It has been theorized that the tartaric-acid core in the drug adheres and damages the esophagus, and then the damaged esophageal mucosa exfoliates after peristalsis. Additionally, patients with limited mobility, reduced salivary secretion, and low water consumption will increase the possibility of contact by dabigatran with the esophageal mucosa.
4342:
1195:
pharmaceutical group of withholding critical information about the need for monitoring to protect patients from severe bleeding, particularly in the elderly. Review of internal communications between
Boehringer researchers and employees by the FDA and the EMA revealed that Boehringer researchers had
1001:
A small but significantly increased risk of myocardial infarctions (heart attacks) has been noted when combining the safety outcome data from multiple trials. However, conflicting evidence from another review suggested that dabigatran might not substantially increase the risk of heart attacks, or if
980:
The most commonly reported side effect of dabigatran is gastrointestinal upset. When compared with people anticoagulated with warfarin, patients taking dabigatran had fewer life-threatening bleeds, fewer minor and major bleeds, including intracranial bleeds, but the rate of gastrointestinal bleeding
968:
guidelines states that patients with mechanical heart valves should not be using dabigatran. The safety and efficacy of
Pradaxa (dabigatran) were evaluated in the European RE-ALIGN trial in 2012. RE-ALIGN was terminated early because the Pradaxa treatment group had significantly more thromboembolic
1187:
In May 2014, the FDA reported the results of a large study comparing dabigatran with warfarin in 134,000 Medicare patients. The agency concluded that dabigatran is associated with a lower risk of overall mortality, ischemic stroke, and bleeding in the brain than warfarin. Gastrointestinal bleeding
951:
Dabigatran is contraindicated in patients who have active pathological bleeding, since dabigatran can increase bleeding risk and can also cause serious and potentially life-threatening bleeds. Dabigatran is also contraindicated in patients who have a history of serious hypersensitivity reaction to
942:
In 2022, an observational meta-analysis study was performed on direct oral anticoagulants for patients with atrial fibrillation. The study found that dabigatran had comparable rates of ischemic stroke or systemic embolism, intracerebral haemorrhage, and all-cause mortality when compared to other
2209:
Hijazi Z, Hohnloser SH, Oldgren J, Andersson U, Connolly SJ, Eikelboom JW, et al. (March 2014). "Efficacy and safety of dabigatran compared with warfarin in relation to baseline renal function in patients with atrial fibrillation: a RE-LY (Randomized
Evaluation of Long-term Anticoagulation
993:
RA), proton pump inhibitors (PPIs) and mucosal protective agent. In severe bleeding, measures include discontinuation of dabigatran immediately, and administration of prothrombin complex concentrate, packed red blood cells, fresh frozen plasma, the use of specific reversal agents such as
2158:
Wei AH, Gu ZC, Zhang C, Ding YF, Liu D, Li J, et al. (September 2018). "Increased risk of myocardial infarction with dabigatran etexilate: fact or fiction? A critical meta-analysis of over 580,000 patients from integrating randomized controlled trials and real-world studies".
1797:
Lau WC, Torre CO, Man KK, Stewart HM, Seager S, Van Zandt M, et al. (November 2022). "Comparative
Effectiveness and Safety Between Apixaban, Dabigatran, Edoxaban, and Rivaroxaban Among Patients With Atrial Fibrillation : A Multinational Population-Based Cohort Study".
943:
anticoagulants like apixaban, edoxaban, and rivaroxaban. Notably, apixaban was associated with a lower risk of gastrointestinal bleeding than dabigatran and the others. This finding was generally steady for patients aged 80 years or older and those with chronic kidney disease.
1180:(FDA) approved Pradaxa in October 2010, for prevention of stroke in patients with non-valvular atrial fibrillation. The approval came after an advisory committee recommended the drug for approval in September 2010, although caution is still urged by some outside experts.
1005:
For patients with moderately reduced kidney function, lower dabigatran doses are recommended due to increased drug exposure and bleeding risk. Alternative anticoagulants should be considered in severe kidney impairment due to insufficient safety and efficacy data.
1057:
of the drug is unaffected. Several studies have demonstrated that dabigatran plasma concentrations are reduced when co-administered with proton pump inhibitors, however it is unclear if this reduction is clinically significant. Dabigatran excretion through
2771:
van Ryn J, Stangier J, Haertter S, Liesenfeld KH, Wienen W, Feuring M, et al. (June 2010). "Dabigatran etexilate--a novel, reversible, oral direct thrombin inhibitor: interpretation of coagulation assays and reversal of anticoagulant activity".
1146:(NHS) in Britain authorized dabigatran for use in preventing blood clots in hip and knee replacement surgery patients. According to a BBC article in 2008, Dabigatran was expected to cost the NHS ÂŁ4.20 per day, which was similar to several other
2518:
Stangier J, Eriksson BI, Dahl OE, Ahnfelt L, Nehmiz G, StÀhle H, et al. (May 2005). "Pharmacokinetic profile of the oral direct thrombin inhibitor dabigatran etexilate in healthy volunteers and patients undergoing total hip replacement".
778:
as etexilate: InChI=1S/C34H41N7O5/c1-4-6-7-10-21-46-34(44)39-32(35)24-12-15-26(16-13-24)37-23-30-38-27-22-25(14-17-28(27)40(30)3)33(43)41(20-18-31(42)45-5-2)29-11-8-9-19-36-29/h8-9,11-17,19,22,37H,4-7,10,18,20-21,23H2,1-3H3,(H2,35,39,44)
969:
events and major bleeding than warfarin and determined to be contraindicated for use in patients with mechanical heart valves. Further studies are needed in order to determine effects of dabigatran on patients with bioprosthetic valves.
2194:
Stangier J, Rathgen K, StÀhle H, Mazur D. Influence of renal impairment on the pharmacokinetics and pharmacodynamics of oral dabigatran etexilate: an open-label, parallel-group, single-centre study. Clinical pharmacokinetics. 2010 Apr;
1188:
was more common in those treated with dabigatran than in those treated with warfarin. The risk of heart attack was similar between the two drugs. The FDA reiterated its opinion that dabigatran's overall risk/benefit ratio is favorable.
3263:
3212:"2011 ACCF/AHA/HRS focused update on the management of patients with atrial fibrillation (update on Dabigatran): a report of the American College of Cardiology Foundation/American Heart Association Task Force on practice guidelines"
1924:
719:
1183:
In
February 2011, the American College of Cardiology Foundation and the American Heart Association added dabigatran to their guidelines for management of non-valvular atrial fibrillation with a class I recommendation.
2245:
An J, Cheetham TC, Luong T, Lang DT, Lee MS, Reynolds K (July 2023). "Effectiveness and safety of
Dabigatran 110 mg versus 150 mg for Stroke Prevention in Patients with Atrial Fibrillation at High Bleeding Risk".
3380:
2806:
Although there is no specific antidote to antagonise the anticoagulant effect of dabigatran, due to its short duration of effect drug discontinuation is usually sufficient to reverse any excessive anticoagulant
3166:
Merli G, Spyropoulos AC, Caprini JA (August 2009). "Use of emerging oral anticoagulants in clinical practice: translating results from clinical trials to orthopedic and general surgical patient populations".
956:
or anaphylactic shock). The use of dabigatran should also be avoided in patients with mechanical prosthetic heart valves due to the increased risk of thromboembolic events (e.g. valve thrombosis, stroke, and
850:; however, dabigatran were associated with a lower hazard for intracranial bleeding compared with warfarin, but also had a higher risk of gastrointestinal bleeding relative to warfarin. It is taken by mouth.
711:
1172:
in June 2008, for the prevention of blood clots in patients who have undergone total hip or total knee replacement surgery. Approval for atrial fibrillation patients at risk of stroke came in
October 2010.
1053:
Dabigatran has a half-life of approximately 12â17 h and exerts a maximum anticoagulation effect within 2 hours after ingestion. Fatty foods delay the intestinal absorption of dabigatran, although the
1153:
Initially, there was no specific way to reverse the anticoagulant effect of dabigatran in the event of a major bleeding event, unlike for warfarin. Since then, the dabigatran-specific antidote
2934:
3252:"FDA Drug Safety Communication: FDA study of Medicare patients finds risks lower for stroke and death but higher for gastrointestinal bleeding with Pradaxa (dabigatran) compared to warfarin"
3251:
2611:
Bolek T, SamoĆĄ M, StanÄiakovĂĄ L, IvankovĂĄ J, Ć korĆovĂĄ I, StaĆĄko J, et al. (May 2019). "The Impact of Proton Pump
Inhibition on Dabigatran Levels in Patients With Atrial Fibrillation".
981:
was significantly higher. Dabigatran capsules contain tartaric acid, which lowers the gastric pH and is required for adequate absorption. The lower pH has previously been associated with
1916:
1016:
The
Randomized Evaluation of Long-Term Anticoagulation Therapy (RE-LY) trial showed that impairment of liver function caused by dabigatran occurred in the same frequency as warfarin.
237:
2913:
767:
InChI=1S/C25H25N7O3/c1-31-20-10-7-17(25(35)32(13-11-23(33)34)21-4-2-3-12-28-21)14-19(20)30-22(31)15-29-18-8-5-16(6-9-18)24(26)27/h2-10,12,14,29H,11,13,15H2,1H3,(H3,26,27)(H,33,34)
985:; some hypothesize that this plays a role in the increased risk of gastrointestinal bleeding. If a small amount of GI bleeding is diagnosed, the clinicians may consider adding H
2651:
1320:
3370:
2985:
Connolly SJ, Ezekowitz MD, Yusuf S, Eikelboom J, Oldgren J, Parekh A, et al. (September 2009). "Dabigatran versus warfarin in patients with atrial fibrillation".
2365:
Connolly SJ, Ezekowitz MD, Yusuf S, Eikelboom J, Oldgren J, Parekh A, et al. (September 2009). "Dabigatran versus warfarin in patients with atrial fibrillation".
2113:
Connolly SJ, Ezekowitz MD, Yusuf S, Eikelboom J, Oldgren J, Parekh A, et al. (September 2009). "Dabigatran versus warfarin in patients with atrial fibrillation".
972:
Dabigatran is poorly excreted in breastmilk and does not appear to require any limitations to breastfeeding. However, data is limited and further studies are needed.
2281:
Toya Y, Nakamura S, Tomita K, Matsuda N, Abe K, Abiko Y, et al. (March 2016). "Dabigatran-induced esophagitis: The prevalence and endoscopic characteristics".
3144:
4417:
1600:
192:
1650:"Dabigatran, Rivaroxaban, or Apixaban versus Warfarin in Patients with Nonvalvular Atrial Fibrillation: A Systematic Review and Meta-Analysis of Subgroups"
1775:
846:
and does not require monitoring by blood tests. In a meta analysis of 7 different studies, there was no benefit of dabigatran over warfarin in preventing
794:
3109:
3087:
112:
4382:
2944:
2672:
Hauel NH, Nar H, Priepke H, Ries U, Stassen JM, Wienen W (April 2002). "Structure-based design of novel potent nonpeptide thrombin inhibitors".
1405:
2707:
1917:"FDA Drug Safety Communication: Pradaxa (dabigatran etexilate mesylate) should not be used in patients with mechanical prosthetic heart valves"
1842:"FDA Drug Safety Communication: Pradaxa (dabigatran etexilate mesylate) should not be used in patients with mechanical prosthetic heart valves"
1105:-alpha-(2-naphthylsulfonylglycyl)-4-amidinophenylalanine piperidide), which had been known since the 1980s as a powerful inhibitor of various
61:
733:
2910:
4083:
3486:
3481:
1350:
4182:
3420:
2648:
3512:
2564:"Influence of proton pump inhibitors on blood dabigatran concentrations in Japanese patients with non-valvular atrial fibrillation"
2968:
2074:"Dabigatran association with higher risk of acute coronary events: meta-analysis of noninferiority randomized controlled trials"
1312:
1277:
3398:
1853:
2471:"Dabigatran: A new oral anticoagulant. Guidelines to follow in oral surgery procedures. A systematic review of the literature"
4296:
1566:
1221:
889:
2749:
1962:
1456:"Dabigatran Versus Warfarin for Atrial Fibrillation in Real-World Clinical Practice: A Systematic Review and Meta-Analysis"
4397:
3133:
939:
in preventing non-hemorrhagic strokes and embolic events in those with atrial fibrillation not due to valve problems.
801:
129:
3667:
1514:
1438:
1143:
759:
2469:
Muñoz-Corcuera M, RamĂrez-MartĂnez-Acitores L, LĂłpez-Pintor RM, Casañas-Gil E, HernĂĄndez-Vallejo G (November 2016).
4313:
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222:
93:
1622:
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3612:
1749:
4043:
1701:"Interventions for Preventing Thromboembolic Events in Patients With Atrial Fibrillation: A Systematic Review"
417:
409:
3413:
1699:
Lowenstern A, Al-Khatib SM, Sharan L, Chatterjee R, Allen LaPointe NM, Shah B, et al. (December 2018).
4412:
3896:
3257:
3117:
3113:
3079:
2023:"Dabigatran must be used carefully: literature review and recommendations for management of adverse events"
1847:
1594:
1177:
1162:
965:
929:
484:
2717:
1875:
Eikelboom JW, Connolly SJ, Brueckmann M, Granger CB, Kappetein AP, Mack MJ, et al. (September 2013).
1243:
3987:
3707:
617:
578:
570:
4407:
4332:
1093:
Dabigatran (then compound BIBR-953) was discovered from a panel of chemicals with similar structure to
1078:
747:
as etexilate: CN1C=2C(=CC(C(N(CCC(OCC)=O)C3=CC=CC=N3)=O)=CC2)N=C1CNC4=CC=C(C(NC(OCCCCCC)=O)=N)C=C4
2326:"Analysis of upper gastrointestinal adverse events among patients given dabigatran in the RE-LY trial"
1983:
Blommel ML, Blommel AL (August 2011). "Dabigatran etexilate: A novel oral direct thrombin inhibitor".
892:. In 2020, it was the 306th most commonly prescribed medication in the United States, with more than 1
4035:
2966:"Pradax (Dabigatran Etexilate) Gains Approval In Canada For Stroke Prevention In Atrial Fibrillation"
2712:
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882:
185:
107:
71:
633:
4372:
3406:
4377:
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3210:
Wann LS, Curtis AB, Ellenbogen KA, Estes NA, Ezekowitz MD, Jackman WM, et al. (March 2011).
3139:
166:
43:
3428:
1748:
Sanders GD, Lowenstern A, Borre E, Chatterjee R, Goode A, Sharan L, et al. (October 2018).
1648:
GĂłmez-Outes A, Terleira-FernĂĄndez AI, Calvo-Rojas G, SuĂĄrez-Gea ML, Vargas-CastrillĂłn E (2013).
3650:
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599:
311:
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550:
542:
4402:
4392:
4178:
2324:
Bytzer P, Connolly SJ, Yang S, Ezekowitz M, Formella S, Reilly PA, et al. (March 2013).
1504:
958:
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356:
348:
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3774:
1192:
1118:
921:
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321:
8:
4387:
3630:
3326:
Moore TJ, Cohen MR, Mattison DR (July 2014). "Dabigatran, bleeding, and the regulators".
2562:
Kuwayama T, Osanai H, Ajioka M, Tokuda K, Ohashi H, Tobe A, et al. (December 2017).
1158:
913:
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2022:
1823:
1725:
1700:
1676:
1649:
1485:
925:
897:
140:
2965:
2223:
928:
in persons who have been treated for 5â10 days with parenteral anticoagulant (usually
389:
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4165:
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3926:
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3906:
3881:
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2000:
1954:
1898:
1841:
1827:
1815:
1767:
1730:
1681:
1510:
1477:
1434:
1269:
932:), and to prevent deep vein thrombosis and pulmonary embolism in some circumstances.
589:
274:
261:
249:
85:
3355:
3196:
2897:
2868:
Syed YY (August 2016). "Idarucizumab: A Review as a Reversal Agent for Dabigatran".
2801:
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2090:
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3901:
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2310:
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2255:
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2085:
2044:
2034:
1992:
1888:
1807:
1757:
1720:
1712:
1671:
1661:
1538:
1489:
1467:
1034:
888:
Dabigatran was approved for medical use in the United States in 2010. It is on the
878:
839:
654:
381:
293:
205:
1750:
Stroke Prevention in Patients With Atrial Fibrillation: A Systematic Review Update
1647:
1558:
1213:
4346:
3943:
3228:
3211:
3180:
2972:
2917:
2744:
2655:
2624:
2172:
1953:, Bethesda (MD): National Institute of Child Health and Human Development, 2006,
1106:
1062:
pumps is slowed in patients taking strong p-glycoprotein pump inhibitors such as
1054:
858:
835:
301:
2739:
4307:
3834:
3520:
3429:
3056:
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1946:
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3437:
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2532:
1169:
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842:
and in those with a history of prior clots. It is used as an alternative to
4254:
4224:
4202:
4197:
4170:
4119:
4098:
3948:
3887:
3843:
3720:
3663:
3602:
3597:
3578:
3476:
3445:
3347:
3312:
3237:
3188:
3110:"FDA approves Pradaxa to prevent stroke in people with atrial fibrillation"
3065:
3016:
2889:
2854:
2793:
2693:
2632:
2597:
2540:
2504:
2455:
2396:
2351:
2302:
2267:
2231:
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2099:
2058:
2004:
1958:
1902:
1819:
1771:
1762:
1734:
1685:
1535:
World Health Organization model list of essential medicines: 21st list 2019
1481:
1154:
1042:
995:
866:
200:
22:
2998:
2486:
2378:
2126:
1893:
1876:
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4021:
3953:
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3535:
3525:
2785:
2039:
1094:
1010:
953:
917:
862:
79:
3007:
2387:
2135:
1543:
1131:(EMA) granted marketing authorization for Pradaxa for the prevention of
1037:. Furthermore, dabigatran can inactivate thrombin even when thrombin is
847:
445:
437:
4229:
4146:
4129:
4114:
4093:
4073:
4016:
4001:
3975:
3965:
3960:
3814:
3783:
3715:
3695:
3673:
3562:
3546:
3542:
3491:
2935:"Approval of new drug heralds 'momentous' advance in stroke prevention"
2436:
1996:
1071:
1009:
Dabigatran intake has also been reported to cause esophageal injury or
687:
456:
180:
30:
3339:
3303:
3286:
2685:
2294:
741:
CN1C=2C(=CC(C(N(CCC(O)=O)C3=CC=CC=N3)=O)=CC2)N=C1CNC4=CC=C(C(=N)N)C=C4
4217:
4212:
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4134:
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4006:
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3751:
3725:
3690:
3678:
3640:
3635:
3625:
3587:
3557:
3552:
3530:
3496:
3471:
1877:"Dabigatran versus warfarin in patients with mechanical heart valves"
1811:
1716:
1454:
Romanelli RJ, Nolting L, Dolginsky M, Kym E, Orrico KB (March 2016).
1067:
1063:
982:
870:
865:. In cases of severe bleeding, it can be reversed with the antidote,
854:
367:
65:
1191:
In July 2014, a series of investigations accused the privately held
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3800:
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1698:
1098:
1030:
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514:
428:
124:
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1117:
and hexyloxycarbonyl carbamide hydrophobic side chains led to the
718:
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3620:
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1110:
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1747:
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2364:
2208:
2112:
1038:
909:
827:
561:
111:
3287:"Dabigatran: how the drug company withheld important analyses"
3506:
2610:
1433:(76 ed.). Pharmaceutical Press. 2018. pp. 135â137.
1114:
701:
533:
1506:
Oral Anticoagulation Therapy: Cases and Clinical Correlation
1453:
1161:
for intravenous administration, was developed, and received
622:
4151:
2517:
2323:
1398:"Dabigatran Etexilate Mesylate Monograph for Professionals"
834:. Specifically it is used to prevent blood clots following
505:
2561:
1077:
Dabigatran is available as dabigatran etexilate mesilate,
3209:
2280:
1529:
1547:. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
3165:
890:
World Health Organization's List of Essential Medicines
1029:
Dabigatran reversibly binds to the active site on the
4330:
1033:
molecule, preventing thrombin-mediated activation of
1002:
it does, then the associated risk is relatively low.
998:
for dabigatran, and emergency endoscopic management.
3080:"Boehringer wins first US OK in blood-thinner race"
2671:
2649:"Pradaxa Summary of Product Characteristics" (2018)
2244:
1923:. U.S. Food and Drug Administration. 21 June 2019.
1307:
1305:
1303:
1301:
1299:
1297:
1295:
1168:Pradaxa received a Notice of Compliance (NOC) from
1041:-bound; it reduces thrombin-mediated inhibition of
416:
408:
3325:
3132:
1796:
1774:. Report No.: 18-EHC018-EFReport No.: 2018-SR-04.
1206:
1135:following hip or knee replacement surgery and for
961:) and major bleeding when compared with warfarin.
1404:. American Society of Health-System Pharmacists.
896:million prescriptions. Dabigatran is available a
4354:
3371:"$ 650 Million to Settle Blood Thinner Lawsuits"
3319:
3040:"New oral anticoagulants in atrial fibrillation"
2020:
2016:
2014:
1460:Circulation: Cardiovascular Quality and Outcomes
1313:"Pradaxa- dabigatran etexilate mesylate capsule"
1292:
388:
380:
3130:
2071:
1754:Agency for Healthcare Research and Quality (US)
355:
347:
2204:
2202:
2157:
1982:
4418:World Health Organization essential medicines
3414:
2475:Medicina Oral, Patologia Oral Y Cirugia Bucal
2021:Lin S, Wang Y, Zhang L, Guan W (6 May 2019).
2011:
3203:
3159:
3134:"New Blood-Thinner Recommended by FDA Panel"
2417:
1589:"Office of Generic Drugs 2020 Annual Report"
1074:, thus raising plasma levels of dabigatran.
128:
2644:
2642:
2199:
1392:
1390:
1388:
1335:
1270:"Summary of Product Characteristics (SmPC)"
1214:"Dabigatran (Pradaxa) Use During Pregnancy"
3421:
3407:
2812:
2764:
2283:Journal of Gastroenterology and Hepatology
2065:
1985:American Journal of Health-System Pharmacy
1386:
1384:
1382:
1380:
1378:
1376:
1374:
1372:
1370:
1368:
1045:and, therefore, may enhance fibrinolysis.
636:
472:
464:
3302:
3227:
3055:
3006:
2911:"Summary Basis of Decision (SBD): Pradax"
2844:
2587:
2494:
2445:
2435:
2386:
2341:
2134:
2089:
2048:
2038:
1892:
1761:
1724:
1675:
1665:
1542:
1471:
853:Common side effects include bleeding and
493:
2978:
2870:American Journal of Cardiovascular Drugs
2639:
2424:AJNR. American Journal of Neuroradiology
2330:Clinical Gastroenterology and Hepatology
1431:British national formulary : BNF 76
4383:Drugs developed by Boehringer Ingelheim
1951:Drugs and Lactation Database (LactMedÂź)
1921:Center for Drug Evaluation and Research
1523:
1425:
1423:
1365:
632:
444:
436:
84:
4355:
3368:
3116:(FDA). 19 October 2010. Archived from
3037:
2932:
2818:
1024:
280:
255:
102:
3402:
3284:
3266:from the original on 11 November 2020
3131:Shirley S. Wang (20 September 2010).
2072:Uchino K, Hernandez AV (March 2012).
1927:from the original on 27 February 2023
1603:from the original on 12 February 2021
1569:from the original on 13 November 2022
1537:. Geneva: World Health Organization.
1502:
598:
577:
569:
549:
541:
268:
119:
70:
2975:Medical News Today. 28 October 2010.
2867:
2752:from the original on 15 January 2009
2732:
2027:Drug Design, Development and Therapy
1856:from the original on 2 November 2014
1559:"Dabigatran - Drug Usage Statistics"
1420:
1124:, BIBR 1048 (dabigatran etexilate).
946:
877:. Compared to warfarin it has fewer
604:
204:
3102:
3072:
2987:The New England Journal of Medicine
2367:The New England Journal of Medicine
2161:International Journal of Cardiology
2115:The New England Journal of Medicine
1881:The New England Journal of Medicine
1224:from the original on 1 October 2020
1048:
879:interactions with other medications
521:
513:
371:
13:
3147:from the original on 24 April 2016
2740:"Clot drug 'could save thousands'"
2418:Comin J, Kallmes DF (March 2012).
1778:from the original on 29 March 2019
1408:from the original on 27 March 2019
1280:from the original on 21 April 2023
1109:, specifically thrombin, but also
975:
14:
4429:
3383:from the original on 11 June 2021
2224:10.1161/circulationaha.113.003628
1323:from the original on 28 June 2021
935:It appears to be as effective as
857:. Other side effects may include
231:
151:
4340:
4036:Direct thrombin (IIa) inhibitors
3464:Glycoprotein IIb/IIIa inhibitors
2613:American Journal of Therapeutics
2521:Journal of Clinical Pharmacology
1353:from the original on 5 June 2023
1137:non-valvular atrial fibrillation
869:. Use is not recommended during
671:
665:
48:Pradaxa, Pradax, Prazaxa, others
29:
3659:Thromboxane synthase inhibitors
3362:
3278:
3244:
3124:
3090:from the original on 4 May 2016
3031:
2959:
2926:
2904:
2861:
2700:
2665:
2604:
2555:
2511:
2462:
2411:
2358:
2317:
2274:
2260:10.1016/j.clinthera.2023.05.007
2238:
2187:
2151:
2106:
2091:10.1001/archinternmed.2011.1666
1976:
1965:from the original on 2 May 2023
1939:
1909:
1868:
1834:
1790:
1741:
1692:
1641:
1615:
1581:
1551:
1473:10.1161/CIRCOUTCOMES.115.002369
1019:
903:
861:and allergic reactions such as
783:Key:KSGXQBZTULBEEQ-UHFFFAOYSA-N
772:Key:YBSJFWOBGCMAKL-UHFFFAOYSA-N
2674:Journal of Medicinal Chemistry
1496:
1447:
1262:
1236:
908:Dabigatran is used to prevent
677:
659:
244:
1:
2825:Journal of Clinical Pathology
2078:Archives of Internal Medicine
1623:"Dabigatran Etexilate Accord"
1244:"Pradaxa Product information"
1199:
3897:Low-molecular-weight heparin
3708:Phosphodiesterase inhibitors
3621:Acetylsalicylic acid/Aspirin
3258:Food and Drug Administration
3229:10.1161/CIR.0b013e31820f14c0
3181:10.1097/SLA.0b013e3181ae6dbe
3114:Food and Drug Administration
2933:Kirkey S (29 October 2010).
2625:10.1097/mjt.0000000000000599
2173:10.1016/j.ijcard.2018.05.048
1848:Food and Drug Administration
1595:Food and Drug Administration
1178:Food and Drug Administration
1163:Food and Drug Administration
930:low molecular weight heparin
814:, sold under the brand name
7:
2819:Hanley JP (November 2004).
1800:Annals of Internal Medicine
1705:Annals of Internal Medicine
10:
4434:
4398:Direct thrombin inhibitors
3038:Turpie AG (January 2008).
2774:Thrombosis and Haemostasis
2210:Therapy) trial analysis".
1756:(Report). Rockville (MD).
1088:
822:used to treat and prevent
649:Chemical and physical data
4291:
4263:
4164:
4107:
4034:
3986:
3875:
3869:(with some II inhibition)
3863:
3773:
3764:
3734:
3706:
3649:
3611:
3573:
3505:
3462:
3453:
2882:10.1007/s40256-016-0181-4
2713:European Medicines Agency
2660:European Medicines Agency
2580:10.1016/j.joa.2017.07.013
2343:10.1016/j.cgh.2012.10.021
1627:European Medicines Agency
1531:World Health Organization
1347:European Medicines Agency
1248:health-products.canada.ca
1129:European Medicines Agency
883:direct thrombin inhibitor
859:bleeding around the spine
791:
755:
729:
699:
686:
653:
648:
616:
588:
560:
532:
504:
483:
455:
427:
399:
366:
338:
333:
320:
310:
300:
292:
221:
216:
191:
186:Direct thrombin inhibitor
179:
165:
139:
92:
78:
60:
52:
42:
37:
28:
3369:Thomas K (28 May 2014).
3057:10.1093/eurheartj/ehm575
2533:10.1177/0091270005274550
1509:. Springer. p. 11.
1165:(FDA) approval in 2015.
16:Anticoagulant medication
3140:The Wall Street Journal
2837:10.1136/jcp.2003.008904
1144:National Health Service
4179:Plasminogen activators
3651:Thromboxane inhibitors
3575:Prostaglandin analogue
3112:(Press release). U.S.
3044:European Heart Journal
2420:"Dabigatran (Pradaxa)"
1763:10.23970/ahrqepccer214
1133:thromboembolic disease
1085:dabigatran etexilate.
4241:serine endopeptidases
3775:Vitamin K antagonists
3285:Cohen D (July 2014).
2999:10.1056/NEJMoa0905561
2971:24 April 2011 at the
2568:Journal of Arrhythmia
2487:10.4317/medoral.21202
2379:10.1056/NEJMoa0905561
2248:Clinical Therapeutics
2127:10.1056/NEJMoa0905561
1894:10.1056/NEJMoa1300615
1276:. 15 September 2022.
989:receptor inhibitor (H
959:myocardial infarction
3988:Direct Xa inhibitors
3820:Ethyl biscoumacetate
3686:Receptor antagonists
2916:14 July 2016 at the
2786:10.1160/TH09-11-0758
2040:10.2147/DDDT.S203112
1220:. 27 December 2018.
1193:Boehringer Ingelheim
1113:. Addition of ethyl
922:deep vein thrombosis
818:among others, is an
4413:2-Pyridyl compounds
3631:Carbasalate calcium
3120:on 20 October 2010.
3086:. 19 October 2010.
2821:"Warfarin reversal"
2654:5 July 2019 at the
1667:10.1155/2013/640723
1159:monoclonal antibody
1127:In March 2008, the
1101:inhibitor α-NAPAP (
1035:coagulation factors
1025:Mechanism of action
920:issues, as well as
914:atrial fibrillation
832:atrial fibrillation
717:as etexilate:
576:as etexilate:
548:as etexilate:
520:as etexilate:
492:as etexilate:
471:as etexilate:
443:as etexilate:
415:as etexilate:
387:as etexilate:
354:as etexilate:
264:(Prescription only)
240:(Prescription only)
56:BIBR-953, BIBR-1048
25:
4318:Never to phase III
4166:Thrombolytic drugs
3882:glycosaminoglycans
3455:Antiplatelet drugs
3442:antiplatelet drugs
3376:The New York Times
2923:. 6 November 2008.
2437:10.3174/ajnr.A3000
1997:10.2146/ajhp100348
926:pulmonary embolism
898:generic medication
21:
4408:Propionate esters
4328:
4327:
4160:
4159:
4030:
4029:
3760:
3759:
3340:10.1136/bmj.g4517
3304:10.1136/bmj.g4670
3222:(10): 1144â1150.
3169:Annals of Surgery
2993:(12): 1139â1151.
2831:(11): 1132â1139.
2748:. 20 April 2008.
2686:10.1021/jm0109513
2373:(12): 1139â1151.
2336:(3): 246â252.e5.
2295:10.1111/jgh.13024
2121:(12): 1139â1151.
1991:(16): 1506â1519.
1887:(13): 1206â1214.
1806:(11): 1515â1524.
1349:. 22 March 2023.
1250:. 22 October 2009
952:dabigatran (e.g.
947:Contraindications
809:
808:
720:Interactive image
712:Interactive image
618:CompTox Dashboard
284:
272:
259:
247:
235:
155:
122:
105:
4425:
4345:
4344:
4343:
4336:
4140:Drotrecogin alfa
4120:Antithrombin III
3971:Dermatan sulfate
3944:Oligosaccharides
3873:
3872:
3771:
3770:
3507:ADP receptor/P2Y
3460:
3459:
3423:
3416:
3409:
3400:
3399:
3393:
3392:
3390:
3388:
3366:
3360:
3359:
3323:
3317:
3316:
3306:
3282:
3276:
3275:
3273:
3271:
3262:. 21 June 2019.
3248:
3242:
3241:
3231:
3207:
3201:
3200:
3163:
3157:
3156:
3154:
3152:
3136:
3128:
3122:
3121:
3106:
3100:
3099:
3097:
3095:
3076:
3070:
3069:
3059:
3035:
3029:
3028:
3010:
2982:
2976:
2963:
2957:
2956:
2954:
2952:
2943:. Archived from
2940:Montreal Gazette
2930:
2924:
2908:
2902:
2901:
2865:
2859:
2858:
2848:
2816:
2810:
2809:
2780:(6): 1116â1127.
2768:
2762:
2761:
2759:
2757:
2736:
2730:
2729:
2727:
2725:
2720:on 2 August 2012
2716:. Archived from
2704:
2698:
2697:
2680:(9): 1757â1766.
2669:
2663:
2646:
2637:
2636:
2619:(3): e308âe313.
2608:
2602:
2601:
2591:
2559:
2553:
2552:
2515:
2509:
2508:
2498:
2481:(6): e679âe688.
2466:
2460:
2459:
2449:
2439:
2415:
2409:
2408:
2390:
2362:
2356:
2355:
2345:
2321:
2315:
2314:
2278:
2272:
2271:
2254:(7): e151âe158.
2242:
2236:
2235:
2206:
2197:
2191:
2185:
2184:
2155:
2149:
2148:
2138:
2110:
2104:
2103:
2093:
2069:
2063:
2062:
2052:
2042:
2018:
2009:
2008:
1980:
1974:
1973:
1972:
1970:
1943:
1937:
1936:
1934:
1932:
1913:
1907:
1906:
1896:
1872:
1866:
1865:
1863:
1861:
1838:
1832:
1831:
1812:10.7326/M22-0511
1794:
1788:
1787:
1785:
1783:
1765:
1745:
1739:
1738:
1728:
1717:10.7326/M18-1523
1696:
1690:
1689:
1679:
1669:
1645:
1639:
1638:
1636:
1634:
1619:
1613:
1612:
1610:
1608:
1585:
1579:
1578:
1576:
1574:
1555:
1549:
1548:
1546:
1527:
1521:
1520:
1503:Kiser K (2017).
1500:
1494:
1493:
1475:
1451:
1445:
1444:
1427:
1418:
1417:
1415:
1413:
1394:
1363:
1362:
1360:
1358:
1339:
1333:
1332:
1330:
1328:
1309:
1290:
1289:
1287:
1285:
1266:
1260:
1259:
1257:
1255:
1240:
1234:
1233:
1231:
1229:
1210:
1107:serine proteases
1049:Pharmacokinetics
895:
840:knee replacement
805:
804:
797:
722:
714:
694:
679:
673:
667:
661:
641:
640:
626:
624:
608:
602:
581:
573:
553:
545:
525:
517:
497:
476:
468:
448:
440:
420:
412:
392:
384:
374:
373:
359:
351:
325:
282:
279:
270:
267:
257:
254:
246:
243:
233:
230:
208:
153:
150:
132:
121:
118:
115:
104:
101:
88:
74:
33:
26:
24:
20:
4433:
4432:
4428:
4427:
4426:
4424:
4423:
4422:
4373:Aromatic amines
4353:
4352:
4351:
4341:
4339:
4331:
4329:
4324:
4323:
4308:Clinical trials
4287:
4259:
4169:
4156:
4103:
4026:
3982:
3885:
3880:
3868:
3859:
3835:1,3-Indandiones
3777:
3756:
3730:
3702:
3645:
3607:
3569:
3521:Thienopyridines
3510:
3501:
3449:
3430:Antithrombotics
3427:
3397:
3396:
3386:
3384:
3367:
3363:
3324:
3320:
3283:
3279:
3269:
3267:
3250:
3249:
3245:
3208:
3204:
3164:
3160:
3150:
3148:
3129:
3125:
3108:
3107:
3103:
3093:
3091:
3078:
3077:
3073:
3036:
3032:
2983:
2979:
2973:Wayback Machine
2964:
2960:
2950:
2948:
2947:on 16 June 2011
2931:
2927:
2918:Wayback Machine
2909:
2905:
2866:
2862:
2817:
2813:
2769:
2765:
2755:
2753:
2745:BBC News Online
2738:
2737:
2733:
2723:
2721:
2706:
2705:
2701:
2670:
2666:
2656:Wayback Machine
2647:
2640:
2609:
2605:
2560:
2556:
2516:
2512:
2467:
2463:
2416:
2412:
2363:
2359:
2322:
2318:
2279:
2275:
2243:
2239:
2207:
2200:
2192:
2188:
2156:
2152:
2111:
2107:
2070:
2066:
2019:
2012:
1981:
1977:
1968:
1966:
1945:
1944:
1940:
1930:
1928:
1915:
1914:
1910:
1873:
1869:
1859:
1857:
1840:
1839:
1835:
1795:
1791:
1781:
1779:
1746:
1742:
1711:(11): 774â787.
1697:
1693:
1646:
1642:
1632:
1630:
1621:
1620:
1616:
1606:
1604:
1587:
1586:
1582:
1572:
1570:
1557:
1556:
1552:
1528:
1524:
1517:
1501:
1497:
1452:
1448:
1441:
1429:
1428:
1421:
1411:
1409:
1396:
1395:
1366:
1356:
1354:
1341:
1340:
1336:
1326:
1324:
1319:. 6 July 2020.
1311:
1310:
1293:
1283:
1281:
1268:
1267:
1263:
1253:
1251:
1242:
1241:
1237:
1227:
1225:
1212:
1211:
1207:
1202:
1119:orally absorbed
1091:
1055:bioavailability
1051:
1027:
1022:
992:
988:
978:
976:Adverse effects
949:
906:
893:
848:ischemic stroke
830:in people with
826:and to prevent
800:
798:
795:(what is this?)
792:
787:
784:
779:
776:
773:
768:
763:
762:
751:
748:
745:
742:
737:
736:
725:
692:
682:
676:
670:
664:
644:
620:
612:
584:
556:
528:
500:
479:
451:
423:
395:
370:
362:
323:
312:Protein binding
302:Bioavailability
294:Pharmacokinetic
288:
212:
168:
161:
142:
135:
17:
12:
11:
5:
4431:
4421:
4420:
4415:
4410:
4405:
4400:
4395:
4390:
4385:
4380:
4378:Benzimidazoles
4375:
4370:
4365:
4350:
4349:
4326:
4325:
4322:
4321:
4320:
4319:
4316:
4305:
4299:
4293:
4292:
4289:
4288:
4286:
4285:
4280:
4275:
4269:
4267:
4261:
4260:
4258:
4257:
4252:
4247:
4237:
4232:
4227:
4222:
4221:
4220:
4215:
4207:
4206:
4205:
4200:
4195:
4190:
4175:
4173:
4162:
4161:
4158:
4157:
4155:
4154:
4149:
4144:
4143:
4142:
4132:
4127:
4122:
4117:
4111:
4109:
4105:
4104:
4102:
4101:
4096:
4091:
4086:
4081:
4076:
4067:
4066:
4065:
4060:
4055:
4040:
4038:
4032:
4031:
4028:
4027:
4025:
4024:
4019:
4014:
4009:
4004:
3999:
3993:
3991:
3984:
3983:
3981:
3980:
3979:
3978:
3973:
3968:
3958:
3957:
3956:
3951:
3941:
3940:
3939:
3934:
3929:
3924:
3919:
3914:
3909:
3904:
3893:
3891:
3870:
3861:
3860:
3858:
3857:
3851:
3846:
3841:
3832:
3827:
3822:
3817:
3812:
3807:
3797:
3795:
3768:
3766:Anticoagulants
3762:
3761:
3758:
3757:
3755:
3754:
3749:
3744:
3738:
3736:
3732:
3731:
3729:
3728:
3723:
3718:
3712:
3710:
3704:
3703:
3701:
3700:
3699:
3698:
3693:
3683:
3682:
3681:
3676:
3671:
3655:
3653:
3647:
3646:
3644:
3643:
3638:
3633:
3628:
3623:
3617:
3615:
3613:COX inhibitors
3609:
3608:
3606:
3605:
3600:
3595:
3590:
3584:
3582:
3571:
3570:
3568:
3567:
3566:
3565:
3560:
3555:
3540:
3539:
3538:
3533:
3528:
3517:
3515:
3508:
3503:
3502:
3500:
3499:
3494:
3489:
3484:
3479:
3474:
3468:
3466:
3457:
3451:
3450:
3438:anticoagulants
3426:
3425:
3418:
3411:
3403:
3395:
3394:
3361:
3318:
3277:
3243:
3202:
3175:(2): 219â228.
3158:
3123:
3101:
3071:
3050:(2): 155â165.
3030:
2977:
2958:
2925:
2903:
2876:(4): 297â304.
2860:
2811:
2763:
2731:
2708:"Pradaxa EPAR"
2699:
2664:
2638:
2603:
2574:(6): 619â623.
2554:
2527:(5): 555â563.
2510:
2461:
2430:(3): 426â428.
2410:
2357:
2316:
2289:(3): 610â614.
2273:
2237:
2218:(9): 961â970.
2198:
2186:
2150:
2105:
2084:(5): 397â402.
2064:
2010:
1975:
1938:
1908:
1867:
1833:
1789:
1740:
1691:
1640:
1614:
1580:
1550:
1522:
1515:
1495:
1466:(2): 126â134.
1446:
1439:
1419:
1364:
1343:"Pradaxa EPAR"
1334:
1291:
1261:
1235:
1204:
1203:
1201:
1198:
1157:, a humanized
1148:anticoagulants
1090:
1087:
1060:P-glycoprotein
1050:
1047:
1026:
1023:
1021:
1018:
990:
986:
977:
974:
948:
945:
916:not caused by
912:in those with
905:
902:
807:
806:
789:
788:
786:
785:
782:
780:
777:
774:
771:
769:
766:
758:
757:
756:
753:
752:
750:
749:
746:
743:
740:
732:
731:
730:
727:
726:
724:
723:
715:
707:
705:
697:
696:
690:
684:
683:
680:
674:
668:
662:
657:
651:
650:
646:
645:
643:
642:
634:DTXSID50175419
629:
627:
614:
613:
611:
610:
594:
592:
586:
585:
583:
582:
574:
566:
564:
558:
557:
555:
554:
546:
538:
536:
530:
529:
527:
526:
518:
510:
508:
502:
501:
499:
498:
489:
487:
481:
480:
478:
477:
469:
461:
459:
453:
452:
450:
449:
441:
433:
431:
425:
424:
422:
421:
413:
405:
403:
397:
396:
394:
393:
385:
377:
375:
364:
363:
361:
360:
352:
344:
342:
336:
335:
331:
330:
327:
318:
317:
314:
308:
307:
304:
298:
297:
290:
289:
287:
286:
277:
265:
252:
241:
227:
225:
219:
218:
214:
213:
211:
210:
197:
195:
189:
188:
183:
177:
176:
171:
169:administration
163:
162:
160:
159:
157:
147:
145:
137:
136:
134:
133:
116:
98:
96:
90:
89:
82:
76:
75:
68:
58:
57:
54:
50:
49:
46:
40:
39:
35:
34:
15:
9:
6:
4:
3:
2:
4430:
4419:
4416:
4414:
4411:
4409:
4406:
4404:
4401:
4399:
4396:
4394:
4391:
4389:
4386:
4384:
4381:
4379:
4376:
4374:
4371:
4369:
4366:
4364:
4361:
4360:
4358:
4348:
4338:
4337:
4334:
4317:
4315:
4312:
4311:
4309:
4306:
4303:
4300:
4298:
4295:
4294:
4290:
4284:
4281:
4279:
4276:
4274:
4271:
4270:
4268:
4266:
4265:Non-medicinal
4262:
4256:
4253:
4251:
4248:
4246:
4242:
4238:
4236:
4235:Streptokinase
4233:
4231:
4228:
4226:
4223:
4219:
4216:
4214:
4211:
4210:
4208:
4204:
4201:
4199:
4196:
4194:
4191:
4189:
4186:
4185:
4184:
4180:
4177:
4176:
4174:
4172:
4171:fibrinolytics
4167:
4163:
4153:
4150:
4148:
4145:
4141:
4138:
4137:
4136:
4133:
4131:
4128:
4126:
4123:
4121:
4118:
4116:
4113:
4112:
4110:
4106:
4100:
4097:
4095:
4092:
4090:
4087:
4085:
4082:
4080:
4077:
4075:
4071:
4068:
4064:
4061:
4059:
4056:
4054:
4051:
4050:
4049:
4045:
4042:
4041:
4039:
4037:
4033:
4023:
4020:
4018:
4015:
4013:
4010:
4008:
4005:
4003:
4000:
3998:
3995:
3994:
3992:
3989:
3985:
3977:
3974:
3972:
3969:
3967:
3964:
3963:
3962:
3959:
3955:
3952:
3950:
3947:
3946:
3945:
3942:
3938:
3935:
3933:
3930:
3928:
3925:
3923:
3920:
3918:
3915:
3913:
3910:
3908:
3905:
3903:
3900:
3899:
3898:
3895:
3894:
3892:
3889:
3883:
3878:
3874:
3871:
3866:
3862:
3856:
3852:
3850:
3847:
3845:
3842:
3840:
3836:
3833:
3831:
3828:
3826:
3825:Phenprocoumon
3823:
3821:
3818:
3816:
3813:
3811:
3810:Coumatetralyl
3808:
3806:
3805:Acenocoumarol
3802:
3799:
3798:
3796:
3793:
3789:
3785:
3781:
3776:
3772:
3769:
3767:
3763:
3753:
3750:
3748:
3745:
3743:
3740:
3739:
3737:
3733:
3727:
3724:
3722:
3719:
3717:
3714:
3713:
3711:
3709:
3705:
3697:
3694:
3692:
3689:
3688:
3687:
3684:
3680:
3677:
3675:
3672:
3669:
3665:
3662:
3661:
3660:
3657:
3656:
3654:
3652:
3648:
3642:
3639:
3637:
3634:
3632:
3629:
3627:
3624:
3622:
3619:
3618:
3616:
3614:
3610:
3604:
3601:
3599:
3596:
3594:
3591:
3589:
3586:
3585:
3583:
3580:
3576:
3572:
3564:
3561:
3559:
3556:
3554:
3551:
3550:
3548:
3544:
3541:
3537:
3534:
3532:
3529:
3527:
3524:
3523:
3522:
3519:
3518:
3516:
3514:
3511:
3504:
3498:
3495:
3493:
3490:
3488:
3485:
3483:
3480:
3478:
3475:
3473:
3470:
3469:
3467:
3465:
3461:
3458:
3456:
3452:
3447:
3443:
3439:
3435:
3434:thrombolytics
3431:
3424:
3419:
3417:
3412:
3410:
3405:
3404:
3401:
3382:
3378:
3377:
3372:
3365:
3357:
3353:
3349:
3345:
3341:
3337:
3333:
3329:
3322:
3314:
3310:
3305:
3300:
3296:
3292:
3288:
3281:
3265:
3261:
3259:
3253:
3247:
3239:
3235:
3230:
3225:
3221:
3217:
3213:
3206:
3198:
3194:
3190:
3186:
3182:
3178:
3174:
3170:
3162:
3146:
3142:
3141:
3135:
3127:
3119:
3115:
3111:
3105:
3089:
3085:
3081:
3075:
3067:
3063:
3058:
3053:
3049:
3045:
3041:
3034:
3026:
3022:
3018:
3014:
3009:
3004:
3000:
2996:
2992:
2988:
2981:
2974:
2970:
2967:
2962:
2946:
2942:
2941:
2936:
2929:
2922:
2921:Health Canada
2919:
2915:
2912:
2907:
2899:
2895:
2891:
2887:
2883:
2879:
2875:
2871:
2864:
2856:
2852:
2847:
2842:
2838:
2834:
2830:
2826:
2822:
2815:
2808:
2803:
2799:
2795:
2791:
2787:
2783:
2779:
2775:
2767:
2751:
2747:
2746:
2741:
2735:
2719:
2715:
2714:
2709:
2703:
2695:
2691:
2687:
2683:
2679:
2675:
2668:
2661:
2657:
2653:
2650:
2645:
2643:
2634:
2630:
2626:
2622:
2618:
2614:
2607:
2599:
2595:
2590:
2585:
2581:
2577:
2573:
2569:
2565:
2558:
2550:
2546:
2542:
2538:
2534:
2530:
2526:
2522:
2514:
2506:
2502:
2497:
2492:
2488:
2484:
2480:
2476:
2472:
2465:
2457:
2453:
2448:
2443:
2438:
2433:
2429:
2425:
2421:
2414:
2406:
2402:
2398:
2394:
2389:
2384:
2380:
2376:
2372:
2368:
2361:
2353:
2349:
2344:
2339:
2335:
2331:
2327:
2320:
2312:
2308:
2304:
2300:
2296:
2292:
2288:
2284:
2277:
2269:
2265:
2261:
2257:
2253:
2249:
2241:
2233:
2229:
2225:
2221:
2217:
2213:
2205:
2203:
2196:
2190:
2182:
2178:
2174:
2170:
2166:
2162:
2154:
2146:
2142:
2137:
2132:
2128:
2124:
2120:
2116:
2109:
2101:
2097:
2092:
2087:
2083:
2079:
2075:
2068:
2060:
2056:
2051:
2046:
2041:
2036:
2033:: 1527â1533.
2032:
2028:
2024:
2017:
2015:
2006:
2002:
1998:
1994:
1990:
1986:
1979:
1964:
1960:
1956:
1952:
1948:
1942:
1926:
1922:
1918:
1912:
1904:
1900:
1895:
1890:
1886:
1882:
1878:
1871:
1855:
1851:
1849:
1843:
1837:
1829:
1825:
1821:
1817:
1813:
1809:
1805:
1801:
1793:
1777:
1773:
1769:
1764:
1759:
1755:
1751:
1744:
1736:
1732:
1727:
1722:
1718:
1714:
1710:
1706:
1702:
1695:
1687:
1683:
1678:
1673:
1668:
1663:
1659:
1655:
1651:
1644:
1629:. 31 May 2023
1628:
1624:
1618:
1602:
1598:
1596:
1590:
1584:
1568:
1564:
1560:
1554:
1545:
1540:
1536:
1532:
1526:
1518:
1516:9783319546438
1512:
1508:
1507:
1499:
1491:
1487:
1483:
1479:
1474:
1469:
1465:
1461:
1457:
1450:
1442:
1440:9780857113382
1436:
1432:
1426:
1424:
1407:
1403:
1399:
1393:
1391:
1389:
1387:
1385:
1383:
1381:
1379:
1377:
1375:
1373:
1371:
1369:
1352:
1348:
1344:
1338:
1322:
1318:
1314:
1308:
1306:
1304:
1302:
1300:
1298:
1296:
1279:
1275:
1271:
1265:
1249:
1245:
1239:
1223:
1219:
1215:
1209:
1205:
1197:
1194:
1189:
1185:
1181:
1179:
1174:
1171:
1170:Health Canada
1166:
1164:
1160:
1156:
1151:
1149:
1145:
1140:
1138:
1134:
1130:
1125:
1123:
1120:
1116:
1112:
1108:
1104:
1100:
1096:
1086:
1084:
1080:
1075:
1073:
1069:
1065:
1061:
1056:
1046:
1044:
1040:
1036:
1032:
1017:
1014:
1012:
1007:
1003:
999:
997:
984:
973:
970:
967:
962:
960:
955:
944:
940:
938:
933:
931:
927:
923:
919:
915:
911:
901:
899:
891:
886:
884:
880:
876:
875:breastfeeding
872:
868:
864:
860:
856:
851:
849:
845:
841:
837:
833:
829:
825:
821:
820:anticoagulant
817:
813:
803:
796:
790:
781:
775:
770:
765:
764:
761:
754:
744:
739:
738:
735:
728:
721:
716:
713:
709:
708:
706:
703:
698:
691:
689:
685:
658:
656:
652:
647:
639:
635:
631:
630:
628:
619:
615:
607:
606:RCSB PDB
601:
596:
595:
593:
591:
587:
580:
575:
572:
568:
567:
565:
563:
559:
552:
547:
544:
540:
539:
537:
535:
531:
524:
519:
516:
512:
511:
509:
507:
503:
496:
491:
490:
488:
486:
482:
475:
470:
467:
463:
462:
460:
458:
454:
447:
442:
439:
435:
434:
432:
430:
426:
419:
414:
411:
407:
406:
404:
402:
398:
391:
386:
383:
379:
378:
376:
369:
365:
358:
353:
350:
346:
345:
343:
341:
337:
332:
328:
326:
319:
315:
313:
309:
305:
303:
299:
295:
291:
285: Rx-only
278:
276:
266:
263:
253:
251:
242:
239:
229:
228:
226:
224:
220:
215:
207:
202:
199:
198:
196:
194:
190:
187:
184:
182:
178:
175:
172:
170:
164:
158:
149:
148:
146:
144:
138:
131:
126:
117:
114:
109:
100:
99:
97:
95:
91:
87:
83:
81:
77:
73:
69:
67:
63:
59:
55:
51:
47:
45:
41:
38:Clinical data
36:
32:
27:
19:
4403:Ethyl esters
4393:Carboxamides
4255:Fibrinolysin
4225:Anistreplase
4203:Desmoteplase
4198:Tenecteplase
4099:Ximelagatran
4078:
3949:Fondaparinux
3888:antithrombin
3844:Diphenadione
3721:Dipyridamole
3664:Dipyridamole
3603:Treprostinil
3598:Prostacyclin
3477:Eptifibatide
3385:. Retrieved
3374:
3364:
3331:
3327:
3321:
3294:
3290:
3280:
3268:. Retrieved
3255:
3246:
3219:
3215:
3205:
3172:
3168:
3161:
3149:. Retrieved
3138:
3126:
3118:the original
3104:
3092:. Retrieved
3074:
3047:
3043:
3033:
3008:11343/221723
2990:
2986:
2980:
2961:
2949:. Retrieved
2945:the original
2938:
2928:
2906:
2873:
2869:
2863:
2828:
2824:
2814:
2805:
2777:
2773:
2766:
2754:. Retrieved
2743:
2734:
2722:. Retrieved
2718:the original
2711:
2702:
2677:
2673:
2667:
2616:
2612:
2606:
2571:
2567:
2557:
2524:
2520:
2513:
2478:
2474:
2464:
2427:
2423:
2413:
2388:11343/221723
2370:
2366:
2360:
2333:
2329:
2319:
2286:
2282:
2276:
2251:
2247:
2240:
2215:
2211:
2193:
2189:
2164:
2160:
2153:
2136:11343/221723
2118:
2114:
2108:
2081:
2077:
2067:
2030:
2026:
1988:
1984:
1978:
1967:, retrieved
1950:
1947:"Dabigatran"
1941:
1929:. Retrieved
1920:
1911:
1884:
1880:
1870:
1858:. Retrieved
1845:
1836:
1803:
1799:
1792:
1780:. Retrieved
1753:
1743:
1708:
1704:
1694:
1657:
1653:
1643:
1631:. Retrieved
1626:
1617:
1605:. Retrieved
1592:
1583:
1571:. Retrieved
1562:
1553:
1544:10665/325771
1534:
1525:
1505:
1498:
1463:
1459:
1449:
1430:
1410:. Retrieved
1401:
1355:. Retrieved
1346:
1337:
1325:. Retrieved
1316:
1282:. Retrieved
1273:
1264:
1252:. Retrieved
1247:
1238:
1226:. Retrieved
1217:
1208:
1190:
1186:
1182:
1175:
1167:
1155:idarucizumab
1152:
1141:
1126:
1102:
1092:
1076:
1052:
1043:fibrinolysis
1028:
1020:Pharmacology
1015:
1008:
1004:
1000:
996:idarucizumab
979:
971:
963:
950:
941:
934:
907:
904:Medical uses
887:
867:idarucizumab
852:
815:
811:
810:
799:
793:
579:ChEMBL539697
322:Elimination
223:Legal status
217:Legal status
94:License data
18:
4304:from market
4125:Defibrotide
4053:Bivalirudin
4022:Rivaroxaban
3961:Heparinoids
3954:Idraparinux
3855:Tioclomarol
3849:Phenindione
3839:Clorindione
3742:Cloricromen
3536:Ticlopidine
3526:Clopidogrel
3387:26 November
3270:13 November
3216:Circulation
2212:Circulation
1969:27 February
1931:27 February
1607:12 February
1357:13 November
1327:13 November
1284:13 November
1254:13 November
1095:benzamidine
1011:esophagitis
954:anaphylaxis
918:heart valve
863:anaphylaxis
824:blood clots
695: g·mol
571:ChEMBL48361
551:CHEBI:70746
543:CHEBI:70752
357:211915-06-9
349:211914-51-1
334:Identifiers
329:12â17 hours
80:MedlinePlus
53:Other names
44:Trade names
4388:Carbamates
4357:Categories
4230:Monteplase
4147:Ramatroban
4130:Nafamostat
4115:Abelacimab
4094:Melagatran
4079:Dabigatran
4074:Argatroban
4017:Otamixaban
4002:Betrixaban
3990:("xabans")
3976:Sulodexide
3966:Danaparoid
3937:Tinzaparin
3927:Parnaparin
3922:Nadroparin
3917:Enoxaparin
3912:Dalteparin
3907:Certoparin
3867:inhibitors
3815:Dicoumarol
3716:Cilostazol
3696:Terutroban
3674:Picotamide
3563:Ticagrelor
3547:nucleoside
3543:Nucleotide
3513:inhibitors
3492:Sibrafiban
3151:20 October
3094:20 October
2951:29 October
2724:30 January
2195:49:259-68.
1860:29 October
1660:: 640723.
1654:Thrombosis
1200:References
1079:formulated
1072:amiodarone
881:. It is a
812:Dabigatran
700:3D model (
688:Molar mass
590:PDB ligand
495:2E18WX195X
457:ChemSpider
401:IUPHAR/BPS
340:CAS Number
181:Drug class
130:Dabigatran
23:Dabigatran
4314:Phase III
4302:Withdrawn
4218:Urokinase
4213:Saruplase
4193:Reteplase
4188:Alteplase
4135:Protein C
4089:Inogatran
4084:Efegatran
4070:Univalent
4063:Lepirudin
4058:Desirudin
4007:Darexaban
3932:Reviparin
3902:Bemiparin
3865:Factor Xa
3801:Coumarins
3778:(inhibit
3752:Vorapaxar
3726:Triflusal
3691:Terbogrel
3679:Terbogrel
3668:+ aspirin
3641:Triflusal
3636:Indobufen
3626:Aloxiprin
3588:Beraprost
3558:Elinogrel
3553:Cangrelor
3531:Prasugrel
3497:Tirofiban
3487:Roxifiban
3482:Orbofiban
3472:Abciximab
3334:: g4517.
3297:: g4670.
2807:activity.
1828:253238819
1573:7 October
1402:Drugs.com
1218:Drugs.com
1176:The U.S.
1068:verapamil
1064:quinidine
983:dyspepsia
871:pregnancy
855:gastritis
390:135565674
324:half-life
167:Routes of
141:Pregnancy
72:Monograph
66:Drugs.com
4368:Anilines
4363:Amidines
4347:Medicine
4044:Bivalent
4012:Edoxaban
3997:Apixaban
3830:Warfarin
3747:Ditazole
3593:Iloprost
3549:analogs
3381:Archived
3356:29090410
3348:25056265
3313:25055829
3264:Archived
3238:21321155
3197:44917732
3189:19638915
3145:Archived
3088:Archived
3066:18096568
3017:19717844
2969:Archived
2914:Archived
2898:11596083
2890:27388764
2855:15509671
2802:37404563
2794:20352166
2756:21 April
2750:Archived
2694:11960487
2652:Archived
2633:28452843
2598:29255511
2549:26441767
2541:15831779
2505:27694780
2456:22345499
2397:19717844
2352:23103906
2303:26102078
2268:37380555
2232:24323795
2181:29801762
2145:19717844
2100:22231617
2059:31190734
2005:21817082
1963:archived
1959:29999803
1925:Archived
1903:23991661
1854:Archived
1820:36315950
1776:Archived
1772:30480925
1735:30383133
1686:24455237
1601:Archived
1567:Archived
1563:ClinCalc
1533:(2019).
1482:26812933
1412:27 March
1406:Archived
1351:Archived
1321:Archived
1317:DailyMed
1278:Archived
1222:Archived
1099:thrombin
1031:thrombin
964:Current
937:warfarin
844:warfarin
802:(verify)
429:DrugBank
193:ATC code
174:By mouth
143:category
125:DailyMed
4283:Oxalate
4273:Citrate
4250:Brinase
4048:Hirudin
3877:Heparin
3853:Other:
3084:Reuters
3025:7425216
2846:1770479
2589:5729000
2496:5116109
2447:7966436
2405:7425216
2311:2601542
2167:: 1â7.
2050:6511609
1726:6825839
1677:3885278
1490:6840541
1122:prodrug
1111:trypsin
1097:-based
1089:History
1083:prodrug
1081:as the
910:strokes
816:Pradaxa
693:471.521
655:Formula
474:4948999
446:DB06695
438:DB14726
368:PubChem
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466:187412
382:216210
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273:
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4108:Other
3735:Other
3352:S2CID
3260:(FDA)
3256:U.S.
3193:S2CID
3021:S2CID
2894:S2CID
2798:S2CID
2545:S2CID
2401:S2CID
2307:S2CID
1850:(FDA)
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1824:S2CID
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2953:2010
2886:PMID
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2790:PMID
2758:2008
2726:2011
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