35:
259:
219:
289:) originate from primate host species (humans, chimpanzees and several New World monkey species). The sequence U22303 has been assigned as the type member of the species, as this was the first pegivirus to be described for this species. Terminology to describe viruses with different hosts has not been approved by the International Committee on Taxonomy of Viruses; however,
284:
are monophyletic and show < 50% nucleotide (55% amino acid) sequence divergence between aligned sequences from the polyprotein from each other. However, all differ by >50% nucleotide (>55% amino acid) divergence from other members of this genus. Pegiviruses assigned to this species
310:
species that originate from primate host species (humans, chimpanzees, and several New World monkey species). The sequence GU566734 has been assigned as the type member of the species, as this was the first pegivirus to be described for this species.
781:
Epstein, Jonathan H; Quan, Phenix-Lan; Briese, Thomas; Street, Craig; Jabado, Omar; Conlan, Sean; Ali Khan, Shahneaz; Verdugo, Dawn; Hossain, M. Jahangir; Hutchison, Stephen K; Egholm, Michael; Luby, Stephen P; Daszak, Peter; Lipkin, W. Ian (2010).
942:
Shi, Mang; Lin, Xian-Dan; Vasilakis, Nikos; Tian, Jun-Hua; Li, Ci-Xiu; Chen, Liang-Jun; Eastwood, Gillian; Diao, Xiu-Nian; Chen, Ming-Hui; Chen, Xiao; Qin, Xin-Cheng; Widen, Steven G; Wood, Thomas G; Tesh, Robert B; Xu, Jianguo;
770:
Deinhardt F, Holmes AW, Capps RB, Popper H (1967) Studies on the transmission of human viral hepatitis to marmoset monkeys. I. Transmission of disease, serial passages, and description of liver lesions. J Exp Med 125 (4)
551:
Simmonds, Peter; Becher, Paul; Bukh, Jens; Gould, Ernest A; Meyers, Gregor; Monath, Tom; Muerhoff, Scott; Pletnev, Alexander; Rico-Hesse, Rebecca; Smith, Donald B; Stapleton, Jack T; Ictv Report, Consortium (2017).
439:(GBV-A and GBV-B) were identified in tamarins that developed hepatitis following inoculation with the 11th GB passage. A number of GBV-A variants were later identified in wild New World monkeys that were captured.
892:
Kapoor, Amit; Kumar, Arvind; Simmonds, Peter; Bhuva, Nishit; Singh
Chauhan, Lokendra; Lee, Bohyun; Sall, Amadou Alpha; Jin, Zhezhen; Morse, Stephen S; Shaz, Beth; Burbelo, Peter D; Lipkin, W. Ian (2015).
495:
Human hepegivirus 1 or Human
Pegivirus 2 (HPgV2) is a virus isolated from 2 multiply transfused hemophiliacs and two transfused patients. This virus appears to belong to a new clade in the Pegiviruses.
722:
Smith, Donald B; Becher, Paul; Bukh, Jens; Gould, Ernest A; Meyers, Gregor; Monath, Thomas; Muerhoff, A. Scott; Pletnev, Alexander; Rico-Hesse, Rebecca; Stapleton, Jack T; Simmonds, Peter (2016).
1116:
Kapoor, A; Simmonds, P; Cullen, J. M; Scheel, T. K. H; Medina, J. L; Giannitti, F; Nishiuchi, E; Brock, K. V; Burbelo, P. D; Rice, C. M; Lipkin, W. I (2013).
1063:
Kapoor, A; Simmonds, P; Scheel, T. K. H; Hjelle, B; Cullen, J. M; Burbelo, P. D; Chauhan, L. V; Duraisamy, R; Sanchez Leon, M; Jain, K; Vandegrift, K. J;
515:
1252:
1265:
207:
201:
195:
183:
177:
165:
153:
147:
629:"The GB viruses: A review and proposed classification of GBV-A, GBV-C (HGV), and GBV-D in genus Pegivirus within the family Flaviviridae"
895:"Virome Analysis of Transfusion Recipients Reveals a Novel Human Virus That Shares Genomic Features with Hepaciviruses and Pegiviruses"
953:"Divergent Viruses Discovered in Arthropods and Vertebrates Revise the Evolutionary History of the Flaviviridae and Related Viruses"
1239:
293:
viruses have been called HPgV for human pegivirus, SPgV for new world simian pegiviruses, and SPgVcpz for chimpanzee simian virus.
306:. This sequence differs by >50% nucleotide (>55% amino acid) divergence from all proposed members of the primate-derived
833:
Chandriani, S; Skewes-Cox, P; Zhong, W; Ganem, D. E; Divers, T. J; Van
Blaricum, A. J; Tennant, B. C; Kistler, A. L (2013).
835:"Identification of a previously undescribed divergent virus from the Flaviviridae in an outbreak of equine serum hepatitis"
489:
784:"Identification of GBV-D, a Novel GB-like Flavivirus from Old World Frugivorous Bats (Pteropus giganteus) in Bangladesh"
300:. Only one virus was included in the naming proposal, which was a complete genome of a virus found in the bat species
1270:
1278:
519:
1049:
724:"Proposed update to the taxonomy of the genera Hepacivirus and Pegivirus within the family Flaviviridae"
34:
1283:
475:
genus was divided into 11 species – pegiviruses A–K with GBV-C classified under pegivirus C species.
1257:
1166:
1311:
678:"Recently agreed changes to the International Code of Virus Classification and Nomenclature"
1306:
1226:
846:
500:
485:
314:
The use of deep sequencing technologies has identified additional viruses that differ from
29:
322:
in rodents, horses, and in different bat species, and Old World monkeys and the number of
8:
1204:
334:
The species known in 2016 have since then been classified into 11 species—Pegivirus A–K.
850:
1142:
1117:
1093:
1068:
1026:
1001:
977:
952:
919:
894:
869:
834:
810:
783:
748:
723:
653:
628:
578:
553:
447:
302:
1213:
1147:
1098:
1031:
982:
924:
874:
815:
753:
699:
658:
583:
247:. The name is a derived one: "Pe" stands for "persistent" and "g" is a reference to
1137:
1129:
1088:
1080:
1064:
1021:
1013:
972:
964:
944:
914:
906:
864:
854:
805:
795:
743:
735:
689:
648:
640:
573:
565:
527:
369:
171:
1218:
525:
Another virus—rodent pegavirus—has been isolated from the white throated woodrat (
1189:
800:
83:
948:
694:
677:
1300:
1002:"Evolutionary and Phylogenetic Analysis of the Hepaciviruses and Pegiviruses"
610:
71:
859:
1151:
1102:
1035:
986:
928:
878:
819:
757:
703:
662:
644:
587:
511:
507:
The human pegiviruses appear to be related to the nonhuman primate species.
119:
107:
95:
1084:
910:
1198:
1133:
1118:"Identification of a Pegivirus (GB Virus-Like Virus) That Infects Horses"
1017:
968:
739:
569:
460:
189:
1244:
1069:"Identification of Rodent Homologs of Hepatitis C Virus and Pegiviruses"
627:
Stapleton, J. T; Foung, S; Muerhoff, A. S; Bukh, J; Simmonds, P (2010).
488:— a form of equine hepatitis — also appears to be caused by a pegivirus—
445:
A more distantly related virus (GBV-D) was later discovered in the bat (
420:
In 1967, experimental inoculation of serum from a thirty four year old
248:
510:
Researchers in 2019 described Human pegivirus-1 as a "cause of human
429:
240:
59:
1160:
676:
Adams, M. J; Lefkowitz, E. J; King, A. M. Q; Carstens, E. B (2013).
1183:
1000:
Thézé, Julien; Lowes, Sophia; Parker, Joe; Pybus, Oliver G (2015).
534:
A pegivirus (equine pegivirus) has also been isolated from a horse.
464:, whereas GBV-A together with GBV-C were assigned to the new genus
258:
218:
1231:
425:
421:
390:
265:
832:
498:
A related virus has been isolated from the graceful catshark (
354:
236:
159:
46:
1115:
1062:
675:
626:
891:
780:
550:
318:
species by >50% nucleotide (>55% amino acid) and
458:
was proposed in 2011. GBV-B was assigned to the genus
999:
362:
includes the virus
Theiler’s disease-associated virus
1050:"Scientists discover a hidden cause of encephalitis"
721:
442:
Subsequently in 1995, a human virus was identified .
941:
296:A second species within the pegiviruses is termed
1298:
622:
620:
839:Proceedings of the National Academy of Sciences
826:
617:
764:
605:
603:
601:
599:
597:
717:
715:
713:
554:"ICTV Virus Taxonomy Profile: Flaviviridae"
1056:
774:
424:(George Barker) with acute hepatitis into
276:Eleven named species are within the genus
1141:
1092:
1025:
993:
976:
918:
885:
868:
858:
809:
799:
747:
693:
652:
594:
577:
710:
257:
217:
935:
435:In 1995, two new members of the family
1299:
1165:
1164:
326:species has been expanded to eleven.
280:. Isolates belonging to the species
669:
410:includes the virus Porcine pegivirus
226:virion (cross section and side view)
1067:; Rice, C. M; Lipkin, W. I (2013).
404:includes the virus Rodent pegivirus
329:
13:
14:
1323:
428:was reported to have resulted in
490:Theiler disease–associated virus
398:includes the virus Bat pegivirus
383:includes the virus Bat pegivirus
377:includes the virus Bat pegivirus
33:
1109:
1042:
544:
1:
538:
1006:Genome Biology and Evolution
801:10.1371/journal.ppat.1000972
518:)"; as well as sexually and
239:of single positive-stranded
7:
728:Journal of General Virology
633:Journal of General Virology
558:Journal of General Virology
271:
235:is the approved name for a
10:
1328:
611:"ICTV Report Flaviviridae"
414:
1173:
695:10.1007/s00705-013-1749-9
144:
139:
28:
21:
479:
347:includes the virus GBV-D
341:includes the virus GBV-A
860:10.1073/pnas.1219217110
251:, a former name of the
222:Schematic drawing of a
645:10.1099/vir.0.027490-0
268:
227:
1085:10.1128/mBio.00216-13
911:10.1128/mBio.01466-15
261:
221:
1134:10.1128/JVI.00324-13
969:10.1128/JVI.02036-15
740:10.1099/jgv.0.000612
682:Archives of Virology
570:10.1099/jgv.0.000672
501:Proscyllium habereri
30:Virus classification
1122:Journal of Virology
957:Journal of Virology
851:2013PNAS..110E1407C
389:includes the virus
368:includes the virus
353:includes the virus
1018:10.1093/gbe/evv202
448:Pteropus giganteus
303:Pteropus giganteus
269:
228:
1294:
1293:
1167:Taxon identifiers
1012:(11): 2996–3008.
734:(11): 2894–2907.
516:Leukoencephalitis
486:Theiler's disease
391:Human pegivirus 2
216:
215:
1319:
1287:
1286:
1274:
1273:
1261:
1260:
1248:
1247:
1235:
1234:
1222:
1221:
1209:
1208:
1207:
1194:
1193:
1192:
1162:
1161:
1156:
1155:
1145:
1113:
1107:
1106:
1096:
1079:(2): e00216–13.
1060:
1054:
1053:
1046:
1040:
1039:
1029:
997:
991:
990:
980:
949:Zhang, Yong-Zhen
945:Holmes, Edward C
939:
933:
932:
922:
905:(5): e01466–15.
889:
883:
882:
872:
862:
845:(15): E1407–15.
830:
824:
823:
813:
803:
778:
772:
768:
762:
761:
751:
719:
708:
707:
697:
673:
667:
666:
656:
624:
615:
614:
607:
592:
591:
581:
548:
528:Neotoma albigula
370:Equine pegivirus
330:Revised taxonomy
38:
37:
19:
18:
16:Genus of viruses
1327:
1326:
1322:
1321:
1320:
1318:
1317:
1316:
1297:
1296:
1295:
1290:
1282:
1277:
1269:
1264:
1256:
1251:
1243:
1238:
1230:
1225:
1217:
1212:
1203:
1202:
1197:
1188:
1187:
1182:
1169:
1159:
1128:(12): 7185–90.
1114:
1110:
1061:
1057:
1048:
1047:
1043:
998:
994:
940:
936:
890:
886:
831:
827:
794:(7): e1000972.
779:
775:
769:
765:
720:
711:
674:
670:
625:
618:
609:
608:
595:
549:
545:
541:
520:mother-to-child
482:
417:
332:
274:
211:
205:
199:
193:
187:
181:
175:
169:
163:
157:
151:
109:Amarillovirales
85:Kitrinoviricota
32:
17:
12:
11:
5:
1325:
1315:
1314:
1309:
1292:
1291:
1289:
1288:
1275:
1262:
1249:
1236:
1223:
1210:
1195:
1179:
1177:
1171:
1170:
1158:
1157:
1108:
1065:Calisher, C. H
1055:
1041:
992:
934:
884:
825:
788:PLOS Pathogens
773:
763:
709:
688:(12): 2633–9.
668:
616:
593:
542:
540:
537:
536:
535:
532:
523:
522:transmissible.
508:
505:
496:
493:
481:
478:
477:
476:
469:
452:
443:
440:
433:
416:
413:
412:
411:
405:
399:
393:
384:
378:
372:
363:
357:
348:
342:
331:
328:
273:
270:
243:in the family
214:
213:
142:
141:
137:
136:
129:
125:
124:
117:
113:
112:
105:
101:
100:
97:Flasuviricetes
93:
89:
88:
81:
77:
76:
69:
65:
64:
57:
50:
49:
44:
40:
39:
26:
25:
15:
9:
6:
4:
3:
2:
1324:
1313:
1310:
1308:
1305:
1304:
1302:
1285:
1280:
1276:
1272:
1267:
1263:
1259:
1254:
1250:
1246:
1241:
1237:
1233:
1228:
1224:
1220:
1215:
1211:
1206:
1200:
1196:
1191:
1185:
1181:
1180:
1178:
1176:
1172:
1168:
1163:
1153:
1149:
1144:
1139:
1135:
1131:
1127:
1123:
1119:
1112:
1104:
1100:
1095:
1090:
1086:
1082:
1078:
1074:
1070:
1066:
1059:
1051:
1045:
1037:
1033:
1028:
1023:
1019:
1015:
1011:
1007:
1003:
996:
988:
984:
979:
974:
970:
966:
963:(2): 659–69.
962:
958:
954:
950:
946:
938:
930:
926:
921:
916:
912:
908:
904:
900:
896:
888:
880:
876:
871:
866:
861:
856:
852:
848:
844:
840:
836:
829:
821:
817:
812:
807:
802:
797:
793:
789:
785:
777:
767:
759:
755:
750:
745:
741:
737:
733:
729:
725:
718:
716:
714:
705:
701:
696:
691:
687:
683:
679:
672:
664:
660:
655:
650:
646:
642:
639:(2): 233–46.
638:
634:
630:
623:
621:
612:
606:
604:
602:
600:
598:
589:
585:
580:
575:
571:
567:
563:
559:
555:
547:
543:
533:
530:
529:
524:
521:
517:
513:
509:
506:
503:
502:
497:
494:
491:
487:
484:
483:
474:
470:
467:
463:
462:
457:
453:
450:
449:
444:
441:
438:
434:
431:
427:
423:
419:
418:
409:
406:
403:
400:
397:
394:
392:
388:
385:
382:
379:
376:
373:
371:
367:
364:
361:
358:
356:
352:
349:
346:
343:
340:
337:
336:
335:
327:
325:
321:
317:
312:
309:
305:
304:
299:
294:
292:
288:
283:
279:
267:
264:
260:
256:
254:
250:
246:
242:
238:
234:
233:
225:
220:
212:
210:
209:
204:
203:
198:
197:
192:
191:
186:
185:
180:
179:
174:
173:
168:
167:
162:
161:
156:
155:
150:
149:
143:
138:
135:
134:
130:
127:
126:
123:
122:
118:
115:
114:
111:
110:
106:
103:
102:
99:
98:
94:
91:
90:
87:
86:
82:
79:
78:
75:
74:
73:Orthornavirae
70:
67:
66:
63:
62:
58:
55:
52:
51:
48:
45:
42:
41:
36:
31:
27:
24:
20:
1312:Virus genera
1174:
1125:
1121:
1111:
1076:
1072:
1058:
1044:
1009:
1005:
995:
960:
956:
937:
902:
898:
887:
842:
838:
828:
791:
787:
776:
766:
731:
727:
685:
681:
671:
636:
632:
561:
557:
546:
526:
512:encephalitis
499:
472:
471:In 2016 the
465:
459:
455:
446:
437:Flaviviridae
436:
407:
401:
395:
386:
380:
374:
365:
359:
350:
344:
338:
333:
323:
319:
315:
313:
308:Pegivirus C
307:
301:
297:
295:
290:
286:
281:
277:
275:
262:
252:
245:Flaviviridae
244:
231:
230:
229:
223:
206:
200:
194:
188:
182:
176:
170:
164:
158:
152:
146:
145:
132:
131:
121:Flaviviridae
120:
108:
96:
84:
72:
60:
53:
43:(unranked):
22:
1307:Pegiviruses
1199:Wikispecies
461:Hepacivirus
408:Pegivirus K
402:Pegivirus J
396:Pegivirus I
387:Pegivirus H
381:Pegivirus G
375:Pegivirus F
366:Pegivirus E
360:Pegivirus D
351:Pegivirus C
345:Pegivirus B
339:Pegivirus A
320:Pegivirus C
316:Pegivirus B
298:Pegivirus B
291:Pegivirus A
287:Pegivirus A
282:Pegivirus C
249:Hepatitis G
241:RNA viruses
208:Pegivirus K
202:Pegivirus J
196:Pegivirus I
190:Pegivirus H
184:Pegivirus G
178:Pegivirus F
172:Pegivirus E
166:Pegivirus D
160:Pegivirus C
154:Pegivirus B
148:Pegivirus A
1301:Categories
564:(1): 2–3.
539:References
454:The genus
1205:Pegivirus
1190:Q16917856
1175:Pegivirus
473:Pegivirus
466:Pegivirus
456:Pegivirus
430:hepatitis
324:Pegivirus
278:Pegivirus
263:Pegivirus
255:species.
232:Pegivirus
224:Pegivirus
133:Pegivirus
68:Kingdom:
61:Riboviria
23:Pegivirus
1258:11903877
1245:10195596
1232:35787766
1184:Wikidata
1152:23596285
1103:23572554
1036:26494702
987:26491167
951:(2016).
929:26396247
879:23509292
820:20617167
758:27692039
704:23836393
663:21084497
588:28218572
426:tamarins
272:Taxonomy
140:Species
116:Family:
80:Phylum:
1271:1307799
1143:3676142
1094:3622934
1027:5635594
978:4702705
920:4600124
870:3625295
847:Bibcode
811:2895649
771:673-688
749:5770844
654:3081076
579:5370391
422:surgeon
415:History
128:Genus:
104:Order:
92:Class:
1284:734232
1150:
1140:
1101:
1091:
1034:
1024:
985:
975:
927:
917:
877:
867:
818:
808:
756:
746:
702:
661:
651:
586:
576:
266:genome
1279:WoRMS
1253:IRMNG
480:Notes
355:GBV-C
237:genus
54:Realm
47:Virus
1266:NCBI
1240:GBIF
1219:6K4Y
1148:PMID
1099:PMID
1073:mBio
1032:PMID
983:PMID
925:PMID
899:mBio
875:PMID
816:PMID
754:PMID
700:PMID
659:PMID
584:PMID
1227:EoL
1214:CoL
1138:PMC
1130:doi
1089:PMC
1081:doi
1022:PMC
1014:doi
973:PMC
965:doi
915:PMC
907:doi
865:PMC
855:doi
843:110
806:PMC
796:doi
744:PMC
736:doi
690:doi
686:158
649:PMC
641:doi
574:PMC
566:doi
1303::
1281::
1268::
1255::
1242::
1229::
1216::
1201::
1186::
1146:.
1136:.
1126:87
1124:.
1120:.
1097:.
1087:.
1075:.
1071:.
1030:.
1020:.
1008:.
1004:.
981:.
971:.
961:90
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