1963:
291:
867:. The neurotransmitter chemical then diffuses across to receptors located on the membrane of the target cell. The neurotransmitter binds to these receptors and activates them. Depending on the type of receptors that are activated, the effect on the target cell can be to excite the target cell, inhibit it, or alter its metabolism in some way. This entire sequence of events often takes place in less than a thousandth of a second. Afterward, inside the presynaptic terminal, a new set of vesicles is moved into position next to the membrane, ready to be released when the next action potential arrives. The action potential is the final electrical step in the integration of synaptic messages at the scale of the neuron.
842:
203:. Axons are distinguished from dendrites by several features, including shape (dendrites often taper while axons usually maintain a constant radius), length (dendrites are restricted to a small region around the cell body while axons can be much longer), and function (dendrites receive signals whereas axons transmit them). Some types of neurons have no axon and transmit signals from their dendrites. In some species, axons can emanate from dendrites known as axon-carrying dendrites. No neuron ever has more than one axon; however in invertebrates such as insects or leeches the axon sometimes consists of several regions that function more or less independently of each other.
350:
942:
can potentially become the axon. This alteration of polarity only occurs when the axon is cut at least 10 μm shorter than the other neurites. After the incision is made, the longest neurite will become the future axon and all the other neurites, including the original axon, will turn into dendrites. Imposing an external force on a neurite, causing it to elongate, will make it become an axon. Nonetheless, axonal development is achieved through a complex interplay between extracellular signaling, intracellular signaling and
832:
49:
1951:
separated from the axon origin. In many species some of the neurons have axons that emanate from the dendrite and not from the cell body, and these are known as axon-carrying dendrites. In many cases, an axon originates at an axon hillock on the soma; such axons are said to have "somatic origin". Some axons with somatic origin have a "proximal" initial segment adjacent the axon hillock, while others have a "distal" initial segment, separated from the soma by an extended axon hillock.
667:
656:
523:
744:, electrical currents produced at each node of Ranvier are conducted with little attenuation to the next node in line, where they remain strong enough to generate another action potential. Thus in a myelinated axon, action potentials effectively "jump" from node to node, bypassing the myelinated stretches in between, resulting in a propagation speed much faster than even the fastest unmyelinated axon can sustain.
1057:
892:(~250μs). 2. The voltage change is triphasic. 3. Activity recorded on a tetrode is seen on only one of the four recording wires. In recordings from freely moving rats, axonal signals have been isolated in white matter tracts including the alveus and the corpus callosum as well hippocampal gray matter.
941:
that are equivalent, yet only one of these neurites is destined to become the axon. It is unclear whether axon specification precedes axon elongation or vice versa, although recent evidence points to the latter. If an axon that is not fully developed is cut, the polarity can change and other neurites
849:
Most axons carry signals in the form of action potentials, which are discrete electrochemical impulses that travel rapidly along an axon, starting at the cell body and terminating at points where the axon makes synaptic contact with target cells. The defining characteristic of an action potential is
565:
The axon initial segment is unmyelinated and contains a specialized complex of proteins. It is between approximately 20 and 60 μm in length and functions as the site of action potential initiation. Both the position on the axon and the length of the AIS can change showing a degree of plasticity
1187:
play an important role in regulating the length of axons. Based on this observation, researchers developed an explicit model for axonal growth describing how motor proteins could affect the axon length on the molecular level. These studies suggest that motor proteins carry signaling molecules from
1950:
In other cases as seen in rat studies an axon originates from a dendrite; such axons are said to have "dendritic origin". Some axons with dendritic origin similarly have a "proximal" initial segment that starts directly at the axon origin, while others have a "distal" initial segment, discernibly
1266:
Later findings by other researchers identified two groups of Aa fibers that were sensory fibers. These were then introduced into a system (Lloyd classification) that only included sensory fibers (though some of these were mixed nerves and were also motor fibers). This system refers to the sensory
1161:
is a type of neurite outgrowth inhibitory component that is present in the central nervous system myelin membranes (found in an axon). It has a crucial role in restricting axonal regeneration in adult mammalian central nervous system. In recent studies, if Nogo-A is blocked and neutralized, it is
611:
in the cell. Microtubules form in the axoplasm at the axon hillock. They are arranged along the length of the axon, in overlapping sections, and all point in the same direction – towards the axon terminals. This is noted by the positive endings of the microtubules. This overlapping
858:
When an action potential reaches a presynaptic terminal, it activates the synaptic transmission process. The first step is rapid opening of calcium ion channels in the membrane of the axon, allowing calcium ions to flow inward across the membrane. The resulting increase in intracellular calcium
1206:
can be classified based on their physical features and signal conduction properties. Axons were known to have different thicknesses (from 0.1 to 20 μm) and these differences were thought to relate to the speed at which an action potential could travel along the axon – its
1182:
Axons vary largely in length from a few micrometers up to meters in some animals. This emphasizes that there must be a cellular length regulation mechanism allowing the neurons both to sense the length of their axons and to control their growth accordingly. It was discovered that
1906:
for this work in 1963. The formulae detailing axonal conductance were extended to vertebrates in the
Frankenhaeuser–Huxley equations. The understanding of the biochemical basis for action potential propagation has advanced further, and includes many details about individual
554:(AIS) is a structurally and functionally separate microdomain of the axon. One function of the initial segment is to separate the main part of an axon from the rest of the neuron; another function is to help initiate action potentials. Both of these functions support neuron
388:, which is specialized to conduct signals very rapidly, is close to 1 millimeter in diameter, the size of a small pencil lead. The numbers of axonal telodendria (the branching structures at the end of the axon) can also differ from one nerve fiber to the next. Axons in the
238:
of the axon closely adjoins the membrane of the target cell, and special molecular structures serve to transmit electrical or electrochemical signals across the gap. Some synaptic junctions appear along the length of an axon as it extends; these are called
854:
characteristic allows action potentials to be transmitted from one end of a long axon to the other without any reduction in size. There are, however, some types of neurons with short axons that carry graded electrochemical signals, of variable amplitude.
612:
arrangement provides the routes for the transport of different materials from the cell body. Studies on the axoplasm has shown the movement of numerous vesicles of all sizes to be seen along cytoskeletal filaments – the microtubules, and
903:
In addition to propagating action potentials to axonal terminals, the axon is able to amplify the action potentials, which makes sure a secure propagation of sequential action potentials toward the axonal terminal. In terms of molecular mechanisms,
1146:
It has also been discovered through research that if the axons of a neuron were damaged, as long as the soma (the cell body of a neuron) is not damaged, the axons would regenerate and remake the synaptic connections with neurons with the help of
1219:
proved this hypothesis, and identified several types of nerve fiber, establishing a relationship between the diameter of an axon and its nerve conduction velocity. They published their findings in 1941 giving the first classification of axons.
863:(tiny containers enclosed by a lipid membrane) filled with a neurotransmitter chemical to fuse with the axon's membrane and empty their contents into the extracellular space. The neurotransmitter is released from the presynaptic nerve through
566:
that can fine-tune the neuronal output. A longer AIS is associated with a greater excitability. Plasticity is also seen in the ability of the AIS to change its distribution and to maintain the activity of neural circuitry at a constant level.
1962:
798:
that function in the release of neurotransmitters. However, axonal varicosities are also present in neurodegenerative diseases where they interfere with the conduction of an action potential. Axonal varicosities are also the hallmark of
870:
Extracellular recordings of action potential propagation in axons has been demonstrated in freely moving animals. While extracellular somatic action potentials have been used to study cellular activity in freely moving animals such as
1759:
takes place at the part of the axon furthest from the cell body. This degeneration takes place quickly following the injury, with the part of the axon being sealed off at the membranes and broken down by macrophages. This is known as
740:, which are found periodically interspersed between segments of the myelin sheath. Therefore, at the point of the node of Ranvier, the axon is reduced in diameter. These nodes are areas where action potentials can be generated. In
899:
in the neurons. Although previous studies indicate an axonal origin of a single spike evoked by short-term pulses, physiological signals in vivo trigger the initiation of sequential spikes at the cell bodies of the neurons.
1037:
content are inversely correlated; when PGMS becomes enriched at the tip of a neurite, its f-actin content is substantially decreased. In addition, exposure to actin-depolimerizing drugs and toxin B (which inactivates
1076:. The filopodia are the mechanism by which the entire process adheres to surfaces and explores the surrounding environment. Actin plays a major role in the mobility of this system. Environments with high levels of
883:
can also be recorded. Extracellular recordings of axon action potential propagation is distinct from somatic action potentials in three ways: 1. The signal has a shorter peak-trough duration (~150μs) than of
1139:, are typically other neurons that are sometimes immature. When the axon has completed its growth at its connection to the target, the diameter of the axon can increase by up to five times, depending on the
485:
The structure of a neuron is seen to consist of two separate functional regions, or compartments – the cell body together with the dendrites as one region, and the axonal region as the other.
3157:
Fletcher TL, Banker GA (December 1989). "The establishment of polarity by hippocampal neurons: the relationship between the stage of a cell's development in situ and its subsequent development in culture".
647:. Dynein is minus-end directed. There are many forms of kinesin and dynein motor proteins, and each is thought to carry a different cargo. The studies on transport in the axon led to the naming of kinesin.
1162:
possible to induce long-distance axonal regeneration which leads to enhancement of functional recovery in rats and mouse spinal cord. This has yet to be done on humans. A recent study has also found that
3493:
Hedgecock EM, Culotti JG, Hall DH (January 1990). "The unc-5, unc-6, and unc-40 genes guide circumferential migrations of pioneer axons and mesodermal cells on the epidermis in C. elegans".
3401:
Serafini T, Kennedy TE, Galko MJ, Mirzayan C, Jessell TM, Tessier-Lavigne M (August 1994). "The netrins define a family of axon outgrowth-promoting proteins homologous to C. elegans UNC-6".
494:
The axonal region or compartment, includes the axon hillock, the initial segment, the rest of the axon, and the axon telodendria, and axon terminals. It also includes the myelin sheath. The
192:, and group C are unmyelinated. These groups include both sensory fibers and motor fibers. Another classification groups only the sensory fibers as Type I, Type II, Type III, and Type IV.
498:
that produce the neuronal proteins are absent in the axonal region. Proteins needed for the growth of the axon, and the removal of waste materials, need a framework for transport. This
1898:
also employed the squid giant axon (1939) and by 1952 they had obtained a full quantitative description of the ionic basis of the action potential, leading to the formulation of the
435:
Schwann cells form the myelin sheath of a myelinated axon. Oligodendrocytes form the insulating myelin in the CNS. Along myelinated nerve fibers, gaps in the myelin sheath known as
970:
netrin receptor is mutated, several neurites are irregularly projected out of neurons and finally a single axon is extended anteriorly. The neurotrophic factors –
1768:, particularly when axonal transport is impaired, this is known as Wallerian-like degeneration. Studies suggest that the degeneration happens as a result of the axonal protein
4312:
230:
but can also make contact with muscle or gland cells. In some circumstances, the axon of one neuron may form a synapse with the dendrites of the same neuron, resulting in an
1223:
Axons are classified in two systems. The first one introduced by
Erlanger and Gasser, grouped the fibers into three main groups using the letters A, B, and C. These groups,
778:. This makes multiple synaptic connections with other neurons possible. Sometimes the axon of a neuron may synapse onto dendrites of the same neuron, when it is known as an
1080:(CAMs) create an ideal environment for axonal growth. This seems to provide a "sticky" surface for axons to grow along. Examples of CAMs specific to neural systems include
1001:
at the tip of neutrites, is required for the elongation of axons. PMGS asymmetrically distributes to the tip of the neurite that is destined to become the future axon.
4434:"Perturbed interactions of mutant proteolipid protein/DM20 with cholesterol and lipid rafts in oligodendroglia: implications for dysmyelination in spastic paraplegia"
689:, or unmyelinated. This is the provision of an insulating layer, called a myelin sheath. The myelin membrane is unique in its relatively high lipid to protein ratio.
1124:. Some of these are surface bound to cells and thus act as short range attractants or repellents. Others are difusible ligands and thus can have long range effects.
246:
A single axon, with all its branches taken together, can target multiple parts of the brain and generate thousands of synaptic terminals. A bundle of axons make a
160:
to the cell body and from the cell body to the spinal cord along another branch of the same axon. Axon dysfunction can be the cause of many inherited and acquired
81:
4571:
125:
1042:) causes the formation of multiple axons. Consequently, the interruption of the actin network in a growth cone will promote its neurite to become the axon.
243:("in passing boutons") and can be in the hundreds or even the thousands along one axon. Other synapses appear as terminals at the ends of axonal branches.
1815:
that axonal damage from a single mild traumatic brain injury, can leave a susceptibility to further damage, after repeated mild traumatic brain injuries.
4866:
4880:
Hsu K, Terakawa S (July 1996). "Fenestration in the myelin sheath of nerve fibers of the shrimp: a novel node of excitation for saltatory conduction".
1013:
is increased at the tip of destined axon. Disrupting the activity of PI3K inhibits axonal development. Activation of PI3K results in the production of
3582:
Da Silva JS, Hasegawa T, Miyagi T, Dotti CG, Abad-Rodriguez J (May 2005). "Asymmetric membrane ganglioside sialidase activity specifies axonal fate".
372:. Some axons can extend up to one meter or more while others extend as little as one millimeter. The longest axons in the human body are those of the
3446:"A ligand-gated association between cytoplasmic domains of UNC5 and DCC family receptors converts netrin-induced growth cone attraction to repulsion"
2957:"CLARITY reveals a more protracted temporal course of axon swelling and disconnection than previously described following traumatic brain injury"
1870:
was the first to describe the gaps or nodes found on axons and for this contribution these axonal features are now commonly referred to as the
4806:
Grant G (December 2006). "The 1932 and 1944 Nobel Prizes in physiology or medicine: rewards for ground-breaking studies in neurophysiology".
380:
to the big toe of each foot. The diameter of axons is also variable. Most individual axons are microscopic in diameter (typically about one
4607:"Repeated mild traumatic brain injuries induce persistent changes in plasma protein and magnetic resonance imaging biomarkers in the rat"
850:
that it is "all-or-nothing" – every action potential that an axon generates has essentially the same size and shape. This
4893:
1014:
4309:
4288:
534:
is the area formed from the cell body of the neuron as it extends to become the axon. It precedes the initial segment. The received
5053:
845:
Neurotransmitter released from presynaptic axon terminal, and transported across synaptic cleft to receptors on postsynaptic neuron
4320:
4714:
2141:
4498:
4263:
3141:
2821:
2739:
2711:
1903:
562:) of a neuron receive input signals at the basal region, and at the apical region the neuron's axon provides output signals.
1935:
has the largest axon known. Its size ranges from 0.5 (typically) to 1 mm in diameter and is used in the control of its
439:
occur at evenly spaced intervals. The myelination enables an especially rapid mode of electrical impulse propagation called
803:. Axonal damage is usually to the axon cytoskeleton disrupting transport. As a consequence protein accumulations such as
4583:
1017:(PtdIns) which can cause significant elongation of a neurite, converting it into an axon. As such, the overexpression of
895:
In fact, the generation of action potentials in vivo is sequential in nature, and these sequential spikes constitute the
1243:). The first group A, was subdivided into alpha, beta, gamma, and delta fibers – Aα, Aβ, Aγ, and Aδ. The
635:
carries cell waste materials from the axon terminal to the cell body. Outgoing and ingoing tracks use different sets of
4749:
2221:
542:
in the neuron are transmitted to the axon hillock for the generation of an action potential from the initial segment.
4860:
4779:
3726:
1188:
the soma to the growth cone and vice versa whose concentration oscillates in time with a length-dependent frequency.
975:
930:
577:
in the initial segment where the action potential is initiated. The ion channels are accompanied by a high number of
5677:
5607:
1756:
659:
1878:, a Spanish anatomist, proposed that axons were the output components of neurons, describing their functionality.
5672:
5602:
5217:
3670:"The axonal glycoprotein TAG-1 is an immunoglobulin superfamily member with neurite outgrowth-promoting activity"
3337:
Arimura N, Kaibuchi K (March 2007). "Neuronal polarity: from extracellular signals to intracellular mechanisms".
3006:"Short duration waveforms recorded extracellularly from freely moving rats are representative of axonal activity"
2080:"Receptive fields, geometry and conduction block of sensory neurones in the central nervous system of the leech"
1939:
system. The fastest recorded conduction speed of 210 m/s, is found in the ensheathed axons of some pelagic
4481:
Matalon R, Michals-Matalon K, Surendran S, Tyring SK (2006). "Canavan
Disease: Studies on the Knockout Mouse".
4207:"Axonal conduction velocity changes following muscle tenotomy or deafferentation during development in the rat"
1093:
913:
804:
1886:
earlier developed the classification system for peripheral nerve fibers, based on axonal conduction velocity,
790:
In the normally developed brain, along the shaft of some axons are located pre-synaptic boutons also known as
5292:
4719:
1081:
958:
surrounding neurons play a prominent role in axonal development. These signaling molecules include proteins,
400:
extend. Elaborate branching allows for the simultaneous transmission of messages to a large number of target
76:
144:. The function of the axon is to transmit information to different neurons, muscles, and glands. In certain
5287:
5275:
5046:
2272:"Axonal Membranes and Their Domains: Assembly and Function of the Axon Initial Segment and Node of Ranvier"
1748:. The dysfunction of axons in the nervous system is one of the major causes of many inherited and acquired
1611:
905:
574:
470:
in the CNS. Where these tracts cross the midline of the brain to connect opposite regions they are called
5327:
5265:
1855:
1808:
1573:
620:
539:
17:
632:
5322:
4969:"Heterogeneity of the Axon Initial Segment in Interneurons and Pyramidal Cells of Rodent Visual Cortex"
1866:
were the first to identify and characterize the axon initial segment. Kölliker named the axon in 1896.
1724:
In order of degree of severity, injury to a nerve in the peripheral nervous system can be described as
758:
An axon can divide into many branches called telodendria (Greek for 'end of tree'). At the end of each
349:
5832:
5682:
5617:
5245:
4692:
3075:"Axons amplify somatic incomplete spikes into uniform amplitudes in mouse cortical pyramidal neurons"
1765:
1537:
1203:
1197:
1140:
462:
of the cerebral cortex which contains the neuronal cell bodies. A similar arrangement is seen in the
432:
259:
165:
157:
1875:
1858:
is generally credited with the discovery of the axon by distinguishing it from the dendrites. Swiss
5612:
5338:
2813:
1899:
1631:
1372:
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800:
64:
4485:. Advances in Experimental Medicine and Biology. Vol. 576. pp. 77–93, discussion 361–3.
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5311:
5039:
4532:"Further evidence for altered myelin biosynthesis and glutamatergic dysfunction in schizophrenia"
2323:"Ankyrin G Membrane Partners Drive the Establishment and Maintenance of the Axon Initial Segment"
1989:
700:. In the central nervous system the myelin sheath is provided by another type of glial cell, the
393:
707:
The composition of myelin is different in the two types. In the CNS the major myelin protein is
5779:
5306:
5070:
3387:
2421:
Rasband MN (August 2010). "The axon initial segment and the maintenance of neuronal polarity".
1819:
1800:
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1077:
578:
389:
251:
169:
88:
2703:
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1859:
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2004:
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also provide a sticky substrate for axons to grow along. Examples of these molecules include
1068:, which is at the tip of the axon. The growth cone has a broad sheet-like extension called a
1039:
507:
392:(CNS) typically show multiple telodendria, with many synaptic end points. In comparison, the
161:
149:
31:
4850:
4605:
Wright DK, Brady RD, Kamnaksh A, Trezise J, Sun M, McDonald SJ, et al. (October 2019).
3238:"Experimental observations on the development of polarity by hippocampal neurons in culture"
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1803:
can result in widespread lesions to nerve tracts damaging the axons in a condition known as
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5659:
5589:
5415:
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4928:
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4004:
3755:
3744:"Laser-based single-axon transection for high-content axon injury and regeneration studies"
3634:
3086:
2846:
2473:"Axon Initial Segment Cytoskeleton: Architecture, Development, and Role in Neuron Polarity"
1666:
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groups as Types and uses Roman numerals: Type Ia, Type Ib, Type II, Type III, and Type IV.
1240:
1236:
1228:
1101:
959:
955:
741:
712:
440:
153:
3895:"Kinesin-5 regulates the growth of the axon by acting as a brake on its microtubule array"
3625:
Bradke F, Dotti CG (March 1999). "The role of local actin instability in axon formation".
2903:"Rapid and Reversible Development of Axonal Varicosities: A New Form of Neural Plasticity"
704:. Schwann cells myelinate a single axon. An oligodendrocyte can myelinate up to 50 axons.
214:. Most axons branch, in some cases very profusely. The end branches of an axon are called
8:
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1984:
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The development of the axon to its target, is one of the six major stages in the overall
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384:(μm) across). The largest mammalian axons can reach a diameter of up to 20 μm. The
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Huang EJ, Reichardt LF (2003). "Trk receptors: roles in neuronal signal transduction".
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Rishal I, Kam N, Perry RB, Shinder V, Fisher EM, Schiavo G, Fainzilber M (June 2012).
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Höfflin F, Jack A, Riedel C, Mack-Bucher J, Roos J, Corcelli C, et al. (2017).
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4383:"Endogenous Nmnat2 is an essential survival factor for maintenance of healthy axons"
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Gensel JC, Nakamura S, Guan Z, van
Rooijen N, Ankeny DP, Popovich PG (March 2009).
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4166:"Properties of fast and slow motor units in hind limb and tail muscles of the rat"
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Rongjing Ge, Hao Qian, Na Chen and Jin-Hui Wang* (2014) Molecular Brain 7(26):1-16
1846:. However, medical sources generally use "nerve fiber" to refer to the axon only.
831:
5557:
5526:
5521:
5403:
5398:
5222:
4432:
Krämer-Albers EM, Gehrig-Burger K, Thiele C, Trotter J, Nave KA (November 2006).
4399:
4316:
4100:
3959:
3768:
3099:
2321:
Leterrier C, Clerc N, Rueda-Boroni F, Montersino A, Dargent B, Castets F (2017).
1879:
1871:
1578:
1406:
1398:
1212:
1148:
1128:
851:
807:
can build up in a swelling resulting in a number of varicosities along the axon.
729:
724:
701:
475:
428:
320:
271:
69:
3386:
express UNC-6 to provide global and local netrin cues for guiding migrations in
966:(also known as UNC-6) a secreted protein, functions in axon formation. When the
48:
5847:
5817:
5774:
5594:
5552:
5530:
5450:
5333:
5157:
5062:
5024:
at the
University of Oklahoma Health Sciences Center – "Slide 3
4630:
4134:
3814:
3668:
Furley AJ, Morton SB, Manalo D, Karagogeos D, Dodd J, Jessell TM (April 1990).
3383:
2240:
2029:"Axons emanating from dendrites: phylogenetic repercussions with Cajalian hues"
1936:
1928:
1883:
1789:
1531:
1476:
1184:
1097:
979:
885:
559:
397:
365:
255:
226:
connection. Axons usually make contact with other neurons at junctions called
145:
141:
4941:
4916:
4819:
4548:
4531:
4016:
3444:
Hong K, Hinck L, Nishiyama M, Poo MM, Tessier-Lavigne M, Stein E (June 1999).
2919:
2772:
2646:
1788:
is the abnormal formation of the myelin sheath. This is implicated in several
1785:
5866:
5496:
5481:
5162:
4985:
4066:
3022:
2592:
2539:
2339:
2288:
2045:
1895:
1793:
1550:
1394:
1171:
1136:
1132:
1069:
1051:
896:
822:
763:
753:
675:
636:
613:
555:
511:
455:
373:
327:
235:
219:
4789:
4490:
2699:
Essential cell biology: an introduction to the molecular biology of the cell
766:(also called a synaptic bouton, or terminal bouton). Axon terminals contain
419:
is a layer of a fatty insulating substance, which is formed by two types of
5742:
5664:
5577:
5458:
5388:
5167:
5090:
5004:
4950:
4827:
4648:
4557:
4508:
4467:
4418:
4367:
4142:
4085:
4034:
3977:
3928:
3879:
3822:
3787:
3654:
3603:
3557:
3471:
3358:
3320:
3253:
3214:
3118:
3041:
2990:
2938:
2874:
2858:
2790:
2665:
2611:
2557:
2508:
2489:
2442:
2407:
2358:
2307:
2248:
2197:
2064:
1999:
1920:
1891:
1863:
1827:
1711:
1306:
1244:
1089:
983:
943:
876:
697:
671:
624:
616:, in both directions between the axon and its terminals and the cell body.
531:
495:
451:
424:
412:
358:
332:
315:
310:
267:
4901:
4281:"Traumatic Brain Injury (TBI) - Definition, Epidemiology, Pathophysiology"
4240:
4191:
3910:
3695:
3514:
3422:
3302:
3271:
3179:
3054:
Rongjing Ge, Hao Qian and Jin-Hui Wang* (2011) Molecular Brain 4(19), 1~11
2113:
5757:
5572:
5476:
5434:
5366:
5361:
5182:
5120:
5115:
5085:
5025:
4170:
Quarterly
Journal of Experimental Physiology and Cognate Medical Sciences
2839:
Proceedings of the Royal
Society of London. Series B, Biological Sciences
2812:(11th ed.). Philadelphia: Lippincott William & Wilkins. p.
1932:
1908:
1733:
1729:
1725:
1158:
1113:
1085:
1065:
1018:
990:
934:
889:
880:
872:
826:
795:
503:
467:
459:
377:
354:
275:
263:
247:
215:
4894:
10.1002/(SICI)1097-4695(199607)30:3<397::AID-NEU8>3.0.CO;2-#
5827:
5516:
5393:
5356:
4431:
3206:
1737:
1607:
1569:
1402:
1163:
864:
679:
463:
381:
300:
133:
4772:
Origins of neuroscience: a history of explorations into brain function
2972:
2220:
Debanne D, Campanac E, Bialowas A, Carlier E, Alcaraz G (April 2011).
1170:
receptor are capable of promoting axon recovery, also however causing
841:
396:
axon is characterized by a single T-shaped branch node from which two
94:
5842:
5376:
5227:
5200:
5192:
4852:
The Brain, the
Nervous System, and Their Diseases [3 volumes]
4480:
4258:(2nd ed.). New York: Oxford University Press. pp. 187–189.
3846:"Macrophages promote axon regeneration with concurrent neurotoxicity"
3379:
2866:
2757:"Oligodendroglial membrane dynamics in relation to myelin biogenesis"
1940:
1073:
1034:
994:
693:
608:
586:
420:
290:
196:
4050:"A frequency-dependent decoding mechanism for axonal length sensing"
3350:
2434:
2320:
2136:(4th ed.). Amsterdam: Elsevier/Academic Press. pp. 61–65.
1021:
that dephosphorylate PtdIns leads into the failure of polarization.
666:
655:
5506:
5491:
5486:
5210:
5205:
5132:
5127:
4117:
3595:
3287:"Mechanical tension can specify axonal fate in hippocampal neurons"
3004:
Robbins AA, Fox SE, Holmes GL, Scott RC, Barry JM (November 2013).
2164:"The development of the corpus callosum in the healthy human brain"
1843:
1778:
causes the multitude of neurological symptoms found in the disease
1166:
activated through a specific inflammatory pathway activated by the
1121:
1117:
604:
522:
295:
211:
207:
200:
4530:
Tkachev D, Mimmack ML, Huffaker SJ, Ryan M, Bahn S (August 2007).
2576:"Structural and Functional Plasticity at the Axon Initial Segment"
1056:
222:
which joins the dendrite or cell body of another neuron forming a
27:
Long projection on a neuron that conducts signals to other neurons
5769:
5730:
5031:
3285:
Lamoureux P, Ruthel G, Buxbaum RE, Heidemann SR (November 2002).
3193:
Jiang H, Rao Y (May 2005). "Axon formation: fate versus growth".
1968:
Recordings in the hippocampus from different cell types and axons
1839:
1109:
938:
835:
779:
640:
231:
227:
223:
1826:, and is one of the many treatments used for different kinds of
526:
Detail showing microtubules at axon hillock and initial segment.
199:
protrusions from the cell body of a neuron; the other type is a
5429:
5384:
5149:
3284:
1887:
1769:
1167:
963:
737:
686:
644:
416:
408:
401:
337:
189:
129:
4741:
2219:
1947:
100–120 m/s for the fastest myelinated vertebrate axon.)
1033:
filament content will become the axon. PGMS concentration and
3843:
1030:
967:
369:
4966:
3667:
3400:
2955:
Weber MT, Arena JD, Xiao R, Wolf JA, Johnson VE (May 2019).
2755:
Ozgen, H; Baron, W; Hoekstra, D; Kahya, N (September 2016).
152:), such as those for touch and warmth, the axons are called
3581:
3136:(5th ed.). Oxford University Press. pp. 520–524.
2630:"Activity-dependent regulation of excitable axonal domains"
1010:
998:
454:
in the brain. The myelin gives the white appearance to the
4604:
4529:
2837:
Hess A, Young JZ (November 1952). "The nodes of
Ranvier".
3801:
Schwab ME (February 2004). "Nogo and axon regeneration".
3742:
Kunik D, Dion C, Ozaki T, Levin LA, Costantino S (2011).
1944:
1943:
and the usual range is between 90 and 200 meters/s (
1812:
982:(NTF3) are also involved in axon development and bind to
692:
In the peripheral nervous system axons are myelinated by
569:
The AIS is highly specialized for the fast conduction of
1822:
is an artificial means of guiding axon growth to enable
937:
neurons suggest that neurons initially produce multiple
585:
that anchor them to the cytoskeleton. Interactions with
156:
and the electrical impulse travels along these from the
4098:
2754:
589:
are important as it is the major organizer in the AIS.
136:, that typically conducts electrical impulses known as
1838:
Some general dictionaries define "nerve fiber" as any
1263:
having the Aα, Aβ, and Aγ nerve fibers, respectively.
3941:
3443:
3003:
2734:(4th ed.). New York: Garland. pp. 979–981.
1397:
are innervated by type Ia, Ib and II sensory fibers,
1064:
Growing axons move through their environment via the
954:
The extracellular signals that propagate through the
4536:
3492:
1764:. Dying back of an axon can also take place in many
407:
There are two types of axons in the nervous system:
128:) is a long, slender projection of a nerve cell, or
4103:, Kruse K (May 2019). "Sound of an axon's growth".
3741:
1060:
Axon of nine-day-old mouse with growth cone visible
962:, and extracellular matrix and adhesion molecules.
670:Cross section of an axon: (1) Axon (2) Nucleus (3)
502:is provided for in the axoplasm by arrangements of
218:. The swollen end of a telodendron is known as the
4047:
3990:
3944:"A motor-driven mechanism for cell-length sensing"
2954:
2161:
3993:"Delayed feedback model of axonal length sensing"
3073:Chen N, Yu J, Qian H, Ge R, Wang JH (July 2010).
2524:"Electrogenic tuning of the axon initial segment"
2521:
1772:, being prevented from reaching all of the axon.
1752:that affect both peripheral and central neurons.
5864:
4794:Kölliker would give the "axon" its name in 1896.
2374:"The Axon Initial Segment: An Updated Viewpoint"
631:needed for growth to the axon terminal. Ingoing
364:Axons are the primary transmission lines of the
3577:
3575:
3336:
3332:
3330:
2522:Clark BD, Goldberg EM, Rudy B (December 2009).
1135:of neuronal axon growth. These cells that help
997:(PMGS), which is involved in the activation of
993:-converting enzyme plasma membrane ganglioside
4331:
4253:
3535:
3156:
2162:Luders E, Thompson PM, Toga AW (August 2010).
1902:. Hodgkin and Huxley were awarded jointly the
1755:When an axon is crushed, an active process of
573:. This is achieved by a high concentration of
5047:
4380:
2470:
2269:
1275:Lower motor neurons have two kind of fibers:
1100:superfamily. Another set of molecules called
558:, in which dendrites (and, in some cases the
4325:
3572:
3327:
3235:
3072:
2702:(2nd ed.). New York: Garland. pp.
2691:
2689:
2687:
2685:
2683:
794:and these have been found in regions of the
643:, and ingoing return traffic is provided by
206:Axons are covered by a membrane known as an
4879:
4808:Journal of the History of the Neurosciences
4334:"Wallerian degeneration, wld(s), and nmnat"
4254:Pocock G, Richards CD, et al. (2004).
3624:
1393:innervate different types of nerve fibers.
1009:During axonal development, the activity of
623:from the cell body along the axon, carries
5054:
5040:
4914:
4564:
4163:
2627:
2573:
2022:
2020:
1015:phosphatidylinositol (3,4,5)-trisphosphate
1004:
949:
466:. Bundles of myelinated axons make up the
450:form the bulk of the neural tissue called
274:, formed of some 200 million axons in the
47:
4994:
4984:
4940:
4849:Hellier, Jennifer L. (16 December 2014).
4638:
4547:
4457:
4408:
4398:
4357:
4230:
4181:
4116:
4075:
4065:
4024:
3967:
3918:
3892:
3869:
3777:
3767:
3685:
3461:
3310:
3261:
3108:
3098:
3031:
3021:
2980:
2928:
2918:
2836:
2780:
2680:
2655:
2645:
2623:
2621:
2601:
2591:
2569:
2567:
2547:
2498:
2488:
2397:
2371:
2348:
2338:
2297:
2287:
2215:
2213:
2211:
2209:
2207:
2187:
2103:
2054:
2044:
919:
545:
3550:10.1146/annurev.biochem.72.121801.161629
3192:
2950:
2948:
2466:
2464:
2462:
2460:
2157:
2155:
2153:
2026:
1705:
1584:
1541:
1481:
1247:of the different motor fibers, were the
1055:
1024:
840:
830:
665:
654:
521:
482:, and this has around 20 million axons.
348:
4848:
4842:
4774:. Oxford University Press. p. 47.
4321:University of California, San Francisco
4204:
3991:Karamched BR, Bressloff PC (May 2015).
3716:
3710:
3131:
3125:
2729:
2695:
2420:
2017:
736:) are short unmyelinated segments of a
14:
5865:
4908:
4769:
4374:
4332:Coleman MP, Freeman MR (1 June 2010).
4278:
3800:
3661:
2803:
2797:
2725:
2723:
2618:
2564:
2204:
2131:
1811:. It has been shown in studies on the
1401:by type II and III sensory fibers and
785:
662:of a myelinated axon in cross-section.
5035:
4962:
4960:
4805:
4381:Gilley J, Coleman MP (January 2010).
2945:
2896:
2894:
2892:
2748:
2634:The Journal of Physiological Sciences
2457:
2263:
2150:
404:within a single region of the brain.
210:; the cytoplasm of an axon is called
4303:
3893:Myers KA, Baas PW (September 2007).
2761:Cellular and Molecular Life Sciences
2127:
2125:
2123:
1954:
1634:has two kinds of peripheral fibers:
1177:
810:
685:In the nervous system, axons may be
639:. Outgoing transport is provided by
4869:from the original on 14 March 2018.
4350:10.1146/annurev-neuro-060909-153248
4048:Bressloff PC, Karamched BR (2015).
2720:
2077:
1923:have been extensively studied. The
1409:by type III and IV sensory fibers.
718:
592:
173:
24:
5061:
4973:Frontiers in Cellular Neuroscience
4957:
4915:Salzer JL, Zalc B (October 2016).
4750:American Psychological Association
4054:Frontiers in Cellular Neuroscience
2900:
2889:
2580:Frontiers in Cellular Neuroscience
2327:Frontiers in Cellular Neuroscience
2276:Frontiers in Cellular Neuroscience
1202:The axons of neurons in the human
916:in response to short-term pulses.
176:into three types –
25:
5884:
5015:
4310:Trauma and Wallerian Degeneration
4291:from the original on 12 June 2018
4164:Andrew BL, Part NJ (April 1972).
3373:
3236:Goslin K, Banker G (April 1989).
2120:
1235:include both the sensory fibers (
1191:
1072:which contain protrusions called
976:brain-derived neurotrophic factor
931:development of the nervous system
836:Synaptic connections from an axon
747:
376:, which run from the base of the
353:A dissected human brain, showing
4183:10.1113/expphysiol.1972.sp002151
1961:
1931:has the longest known axon. The
1914:
489:
289:
5218:Oligodendrocyte progenitor cell
4873:
4799:
4763:
4734:
4707:
4680:
4655:
4598:
4523:
4474:
4425:
4272:
4247:
4198:
4157:
4092:
4041:
3984:
3935:
3886:
3837:
3803:Current Opinion in Neurobiology
3794:
3735:
3721:(Sixth ed.). p. 947.
3618:
3529:
3486:
3437:
3394:
3278:
3229:
3186:
3150:
3066:
3057:
3048:
2997:
2830:
2628:Susuki K, Kuba H (March 2016).
2515:
1744:. Axonal injury can also cause
1096:, all of which are part of the
517:
195:An axon is one of two types of
4450:10.1523/JNEUROSCI.3581-06.2006
4223:10.1113/jphysiol.1980.sp013085
3862:10.1523/JNEUROSCI.3992-08.2009
2471:Jones SL, Svitkina TM (2016).
2414:
2390:10.1523/jneurosci.1922-17.2018
2365:
2314:
2270:Nelson AD, Jenkins PM (2017).
2180:10.1523/JNEUROSCI.5122-09.2010
2096:10.1113/jphysiol.1976.sp011643
2071:
1833:
1151:. This is also referred to as
924:
805:amyloid-beta precursor protein
650:
474:. The largest of these is the
446:The myelinated axons from the
53:An axon of a multipolar neuron
13:
1:
4338:Annual Review of Neuroscience
3719:Molecular biology of the cell
3647:10.1126/science.283.5409.1931
3538:Annual Review of Biochemistry
3463:10.1016/S0092-8674(00)80804-1
2732:Molecular biology of the cell
2372:Leterrier C (February 2018).
2010:
1740:is considered a mild form of
906:voltage-gated sodium channels
575:voltage-gated sodium channels
344:Structure of a typical neuron
4746:APA Dictionary of Psychology
4400:10.1371/journal.pbio.1000300
4279:Dawodu ST (16 August 2017).
3960:10.1016/j.celrep.2012.05.013
3769:10.1371/journal.pone.0026832
3687:10.1016/0092-8674(90)90223-2
3507:10.1016/0896-6273(90)90444-K
3415:10.1016/0092-8674(94)90420-0
3339:Nature Reviews. Neuroscience
3172:10.1016/0012-1606(89)90269-8
3100:10.1371/journal.pone.0011868
3010:Frontiers in Neural Circuits
2808:Langman's medical embryology
2423:Nature Reviews. Neuroscience
1625:
1612:anterior spinothalamic tract
1088: – an axonal
1029:The neurite with the lowest
7:
5328:Postganglionic nerve fibers
4438:The Journal of Neuroscience
4205:Russell NJ (January 1980).
3899:The Journal of Cell Biology
3850:The Journal of Neuroscience
3291:The Journal of Cell Biology
3242:The Journal of Cell Biology
2378:The Journal of Neuroscience
2168:The Journal of Neuroscience
1973:
1856:Otto Friedrich Karl Deiters
1842:, including both axons and
1809:persistent vegetative state
1574:lateral spinothalamic tract
933:. Studies done on cultured
908:in the axons possess lower
368:, and as bundles they form
10:
5889:
5622:
5323:Preganglionic nerve fibers
4720:Taber's Medical Dictionary
4631:10.1038/s41598-019-51267-w
4135:10.1103/PhysRevE.99.050401
3815:10.1016/j.conb.2004.01.004
2241:10.1152/physrev.00048.2009
1860:Rüdolf Albert von Kölliker
1849:
1766:neurodegenerative diseases
1709:
1538:cutaneous mechanoreceptors
1380:
1195:
1049:
875:, axonal activity in both
820:
814:
751:
722:
596:
281:
270:tract in the brain is the
29:
5833:Olfactory receptor neuron
5788:
5729:
5722:
5658:
5588:
5545:
5505:
5497:Neurofibril/neurofilament
5467:
5449:
5442:
5428:
5375:
5347:
5253:
5244:
5191:
5148:
5141:
5078:
5069:
4942:10.1016/j.cub.2016.07.074
4820:10.1080/09647040600638981
4693:Oxford English Dictionary
4572:"Brain Injury, Traumatic"
4549:10.1017/S1461145706007334
4211:The Journal of Physiology
4017:10.1016/j.bpj.2015.03.055
3134:Principles of development
2920:10.3389/fnmol.2021.610857
2773:10.1007/s00018-016-2228-8
2647:10.1007/s12576-015-0413-4
2574:Yamada R, Kuba H (2016).
2084:The Journal of Physiology
2033:Frontiers in Neuroanatomy
1582:
1486:
1484:
1204:peripheral nervous system
1198:Nerve conduction velocity
1045:
433:peripheral nervous system
260:peripheral nervous system
87:
75:
63:
58:
46:
41:
4986:10.3389/fncel.2017.00332
4067:10.3389/fncel.2015.00281
3023:10.3389/fncir.2013.00181
2593:10.3389/fncel.2016.00250
2540:10.1177/1073858409341973
2340:10.3389/fncel.2017.00006
2289:10.3389/fncel.2017.00136
2134:Fundamental neuroscience
2078:Yau KW (December 1976).
2046:10.3389/fnana.2014.00133
1632:autonomic nervous system
1373:Intrafusal muscle fibers
1331:Extrafusal muscle fibers
1270:
1239:) and the motor fibers (
801:traumatic brain injuries
4882:Journal of Neurobiology
4491:10.1007/0-387-30172-0_6
3717:Alberts, Bruce (2015).
3132:Wolpert, Lewis (2015).
1990:Giant axonal neuropathy
1530:Secondary receptors of
1078:cell adhesion molecules
1005:Intracellular signaling
950:Extracellular signaling
711:, and in the PNS it is
579:cell adhesion molecules
394:cerebellar granule cell
5780:Neuromuscular junction
5643:III or Aδ or fast pain
3254:10.1083/jcb.108.4.1507
2859:10.1098/rspb.1952.0063
2132:Squire, Larry (2013).
1876:Santiago Ramón y Cajal
1820:nerve guidance conduit
1801:traumatic brain injury
1776:Demyelination of axons
1762:Wallerian degeneration
1750:neurological disorders
1534:(flower-spray ending).
1356:Gamma (γ) motor neuron
1314:Alpha (α) motor neuron
1092: – and
1061:
920:Development and growth
846:
838:
682:
663:
552:axonal initial segment
546:Axonal initial segment
527:
508:intermediate filaments
478:that connects the two
390:central nervous system
361:
252:central nervous system
162:neurological disorders
150:pseudounipolar neurons
89:Anatomical terminology
5022:Histology image: 3_09
3911:10.1083/jcb.200702074
3303:10.1083/jcb.200207174
3160:Developmental Biology
2229:Physiological Reviews
2005:Single-unit recording
1925:longfin inshore squid
1868:Louis-Antoine Ranvier
1807:. This can lead to a
1805:diffuse axonal injury
1746:central chromatolysis
1742:diffuse axonal injury
1720:Demyelinating disease
1716:Peripheral neuropathy
1706:Clinical significance
1686:postganglionic fibers
1567:of touch and pressure
1479:(annulospiral ending)
1475:Primary receptors of
1338:Beta (β) motor neuron
1196:Further information:
1059:
1025:Cytoskeletal dynamics
859:concentration causes
844:
834:
821:Further information:
669:
658:
621:anterograde transport
607:is the equivalent of
525:
352:
188:. Groups A and B are
164:that affect both the
154:afferent nerve fibers
32:Axon (disambiguation)
5798:Meissner's corpuscle
5763:Postsynaptic density
5660:Efferent nerve fiber
5648:IV or C or slow pain
5590:Afferent nerve fiber
5416:Satellite glial cell
4099:Folz F, Wettmann L,
2490:10.1155/2016/6808293
2027:Triarhou LC (2014).
1900:Hodgkin–Huxley model
1667:preganglionic fibers
1413:Sensory fiber types
1209:conductance velocity
1102:extracellular matrix
960:neurotrophic factors
956:extracellular matrix
742:saltatory conduction
713:myelin basic protein
633:retrograde transport
480:cerebral hemispheres
441:saltatory conduction
234:. At a synapse, the
186:group C nerve fibers
182:group B nerve fibers
178:group A nerve fibers
126:spelling differences
30:For other uses, see
5803:Merkel nerve ending
4933:2016CBio...26.R971S
4623:2019NatSR...914626W
4127:2019PhRvE..99e0401F
4009:2015BpJ...108.2408K
3997:Biophysical Journal
3760:2011PLoSO...626832K
3639:1999Sci...283.1931B
3584:Nature Neuroscience
3195:Nature Neuroscience
3091:2010PLoSO...511868C
2851:1952RSPSB.140..301H
2804:Sadler, T. (2010).
1985:Ganglionic eminence
1757:axonal degeneration
1639:
1414:
1300:Conduction velocity
1280:
1249:lower motor neurons
1141:speed of conduction
972:nerve growth factor
792:axonal varicosities
786:Axonal varicosities
774:for release at the
709:proteolipid protein
458:in contrast to the
172:. Nerve fibers are
5838:Photoreceptor cell
5808:Pacinian corpuscle
5739:Electrical synapse
5693:Lower motor neuron
5688:Upper motor neuron
5409:Internodal segment
5349:Connective tissues
5319:Autonomic ganglion
4611:Scientific Reports
4315:2 May 2006 at the
3207:10.1038/nn0505-544
2907:Front Mol Neurosci
2730:Alberts B (2002).
2696:Alberts B (2004).
2528:The Neuroscientist
2143:978-0-12-385-870-2
1927:, often used as a
1890:, fiber size etc.
1780:multiple sclerosis
1637:
1565:Free nerve endings
1507:Golgi tendon organ
1412:
1279:Motor fiber types
1278:
1261:gamma motor neuron
1253:alpha motor neuron
1251: –
1106:adhesion molecules
1062:
847:
839:
734:myelin sheath gaps
683:
664:
528:
362:
241:en passant boutons
5860:
5859:
5856:
5855:
5823:Free nerve ending
5790:Sensory receptors
5718:
5717:
5633:Ib or Golgi or Aα
5541:
5540:
5424:
5423:
5301:Ramus communicans
5240:
5239:
5236:
5235:
5106:Commissural fiber
5101:Association fiber
5096:Projection fibers
4927:(20): R971–R975.
4770:Finger S (1994).
4500:978-0-387-30171-6
4483:N-Acetylaspartate
4265:978-0-19-858527-5
4105:Physical Review E
3143:978-0-19-967814-3
2973:10.1111/bpa.12677
2823:978-0-7817-9069-7
2741:978-0-8153-4072-0
2713:978-0-8153-3481-1
2477:Neural Plasticity
2222:"Axon physiology"
1980:Electrophysiology
1955:Additional images
1854:German anatomist
1824:neuroregeneration
1703:
1702:
1623:
1622:
1441:sensory receptors
1391:sensory receptors
1378:
1377:
1257:beta motor neuron
1178:Length regulation
1153:neuroregeneration
914:refractory period
861:synaptic vesicles
811:Action potentials
768:synaptic vesicles
629:membrane proteins
583:scaffold proteins
536:action potentials
264:placental mammals
138:action potentials
109:(from Greek ἄξων
103:
102:
98:
16:(Redirected from
5880:
5753:Synaptic vesicle
5748:Chemical synapse
5727:
5726:
5447:
5446:
5440:
5439:
5251:
5250:
5146:
5145:
5076:
5075:
5056:
5049:
5042:
5033:
5032:
5009:
5008:
4998:
4988:
4964:
4955:
4954:
4944:
4912:
4906:
4905:
4877:
4871:
4870:
4846:
4840:
4839:
4803:
4797:
4796:
4767:
4761:
4760:
4758:
4756:
4738:
4732:
4731:
4729:
4727:
4711:
4705:
4704:
4702:
4700:
4684:
4678:
4677:
4675:
4673:
4659:
4653:
4652:
4642:
4602:
4596:
4595:
4593:
4591:
4582:. Archived from
4568:
4562:
4561:
4551:
4527:
4521:
4520:
4478:
4472:
4471:
4461:
4444:(45): 11743–52.
4429:
4423:
4422:
4412:
4402:
4378:
4372:
4371:
4361:
4329:
4323:
4307:
4301:
4300:
4298:
4296:
4276:
4270:
4269:
4256:Human Physiology
4251:
4245:
4244:
4234:
4202:
4196:
4195:
4185:
4161:
4155:
4154:
4120:
4096:
4090:
4089:
4079:
4069:
4045:
4039:
4038:
4028:
3988:
3982:
3981:
3971:
3939:
3933:
3932:
3922:
3890:
3884:
3883:
3873:
3841:
3835:
3834:
3798:
3792:
3791:
3781:
3771:
3739:
3733:
3732:
3714:
3708:
3707:
3689:
3665:
3659:
3658:
3633:(5409): 1931–4.
3622:
3616:
3615:
3579:
3570:
3569:
3533:
3527:
3526:
3490:
3484:
3483:
3465:
3441:
3435:
3434:
3398:
3392:
3377:
3371:
3370:
3334:
3325:
3324:
3314:
3282:
3276:
3275:
3265:
3233:
3227:
3226:
3190:
3184:
3183:
3154:
3148:
3147:
3129:
3123:
3122:
3112:
3102:
3070:
3064:
3061:
3055:
3052:
3046:
3045:
3035:
3025:
3001:
2995:
2994:
2984:
2952:
2943:
2942:
2932:
2922:
2898:
2887:
2886:
2834:
2828:
2827:
2811:
2801:
2795:
2794:
2784:
2767:(17): 3291–310.
2752:
2746:
2745:
2727:
2718:
2717:
2693:
2678:
2677:
2659:
2649:
2625:
2616:
2615:
2605:
2595:
2571:
2562:
2561:
2551:
2519:
2513:
2512:
2502:
2492:
2468:
2455:
2454:
2418:
2412:
2411:
2401:
2384:(9): 2135–2145.
2369:
2363:
2362:
2352:
2342:
2318:
2312:
2311:
2301:
2291:
2267:
2261:
2260:
2226:
2217:
2202:
2201:
2191:
2174:(33): 10985–90.
2159:
2148:
2147:
2129:
2118:
2117:
2107:
2075:
2069:
2068:
2058:
2048:
2024:
1995:Neuronal tracing
1965:
1872:nodes of Ranvier
1840:neuronal process
1790:leukodystrophies
1640:
1636:
1616:Warmth receptors
1453:thermoreceptors
1415:
1411:
1399:mechanoreceptors
1385:
1384:
1281:
1277:
817:Action potential
772:neurotransmitter
730:Nodes of Ranvier
719:Nodes of Ranvier
599:Axonal transport
593:Axonal transport
500:axonal transport
448:cortical neurons
437:nodes of Ranvier
429:oligodendrocytes
386:squid giant axon
293:
95:edit on Wikidata
92:
51:
39:
38:
21:
5888:
5887:
5883:
5882:
5881:
5879:
5878:
5877:
5863:
5862:
5861:
5852:
5784:
5714:
5663:
5654:
5638:II or Aβ and Aγ
5593:
5584:
5537:
5527:Apical dendrite
5522:Dendritic spine
5501:
5463:
5433:
5420:
5404:Node of Ranvier
5399:Myelin incisure
5371:
5343:
5232:
5223:Oligodendrocyte
5206:Ependymal cells
5187:
5137:
5065:
5060:
5018:
5013:
5012:
4965:
4958:
4921:Current Biology
4913:
4909:
4878:
4874:
4863:
4847:
4843:
4804:
4800:
4782:
4768:
4764:
4754:
4752:
4740:
4739:
4735:
4725:
4723:
4713:
4712:
4708:
4698:
4696:
4686:
4685:
4681:
4671:
4669:
4667:Merriam-Webster
4661:
4660:
4656:
4603:
4599:
4589:
4587:
4570:
4569:
4565:
4528:
4524:
4501:
4479:
4475:
4430:
4426:
4393:(1): e1000300.
4379:
4375:
4330:
4326:
4317:Wayback Machine
4308:
4304:
4294:
4292:
4277:
4273:
4266:
4252:
4248:
4203:
4199:
4162:
4158:
4111:(5–1): 050401.
4097:
4093:
4046:
4042:
3989:
3985:
3940:
3936:
3891:
3887:
3856:(12): 3956–68.
3842:
3838:
3799:
3795:
3740:
3736:
3729:
3715:
3711:
3666:
3662:
3623:
3619:
3580:
3573:
3534:
3530:
3491:
3487:
3442:
3438:
3399:
3395:
3384:pioneer neurons
3378:
3374:
3351:10.1038/nrn2056
3335:
3328:
3283:
3279:
3234:
3230:
3191:
3187:
3155:
3151:
3144:
3130:
3126:
3071:
3067:
3062:
3058:
3053:
3049:
3002:
2998:
2953:
2946:
2899:
2890:
2845:(900): 301–20.
2835:
2831:
2824:
2802:
2798:
2753:
2749:
2742:
2728:
2721:
2714:
2694:
2681:
2626:
2619:
2572:
2565:
2520:
2516:
2469:
2458:
2435:10.1038/nrn2852
2419:
2415:
2370:
2366:
2319:
2315:
2268:
2264:
2224:
2218:
2205:
2160:
2151:
2144:
2130:
2121:
2076:
2072:
2025:
2018:
2013:
1976:
1969:
1966:
1957:
1941:Penaeid shrimps
1917:
1880:Joseph Erlanger
1852:
1836:
1722:
1710:Main articles:
1708:
1661:velocity (m/s)
1660:
1652:
1647:
1646:Erlanger-Gasser
1628:
1614:
1579:thermoreceptors
1576:
1568:
1535:
1452:
1451:Nociceptors and
1435:
1427:
1422:
1421:Erlanger-Gasser
1407:thermoreceptors
1387:
1382:
1381:
1302:(meters/second)
1301:
1293:
1288:
1287:Erlanger-Gasser
1273:
1200:
1194:
1180:
1174:in the neuron.
1149:guidepost cells
1129:guidepost cells
1054:
1048:
1027:
1007:
952:
927:
922:
886:pyramidal cells
829:
819:
813:
788:
770:that store the
756:
750:
738:myelinated axon
732:(also known as
727:
725:Node of Ranvier
721:
702:oligodendrocyte
653:
601:
595:
548:
520:
492:
476:corpus callosum
398:parallel fibers
347:
346:
345:
342:
341:
340:
335:
330:
325:
322:
318:
313:
308:
303:
298:
284:
272:corpus callosum
170:central neurons
146:sensory neurons
142:nerve cell body
99:
54:
35:
28:
23:
22:
15:
12:
11:
5:
5886:
5876:
5875:
5873:Neurohistology
5858:
5857:
5854:
5853:
5851:
5850:
5848:Taste receptor
5845:
5840:
5835:
5830:
5825:
5820:
5818:Muscle spindle
5815:
5813:Ruffini ending
5810:
5805:
5800:
5794:
5792:
5786:
5785:
5783:
5782:
5777:
5775:Ribbon synapse
5772:
5767:
5766:
5765:
5760:
5755:
5745:
5735:
5733:
5724:
5720:
5719:
5716:
5715:
5713:
5712:
5711:
5710:
5705:
5700:
5690:
5685:
5680:
5675:
5669:
5667:
5656:
5655:
5653:
5652:
5651:
5650:
5645:
5640:
5635:
5630:
5620:
5615:
5610:
5605:
5599:
5597:
5595:Sensory neuron
5586:
5585:
5583:
5582:
5581:
5580:
5570:
5565:
5563:Pseudounipolar
5560:
5555:
5549:
5547:
5543:
5542:
5539:
5538:
5536:
5535:
5534:
5533:
5531:Basal dendrite
5524:
5519:
5511:
5509:
5503:
5502:
5500:
5499:
5494:
5489:
5484:
5482:Axon terminals
5479:
5473:
5471:
5465:
5464:
5462:
5461:
5455:
5453:
5444:
5437:
5426:
5425:
5422:
5421:
5419:
5418:
5413:
5412:
5411:
5406:
5401:
5396:
5381:
5379:
5373:
5372:
5370:
5369:
5364:
5359:
5353:
5351:
5345:
5344:
5342:
5341:
5336:
5334:Nerve fascicle
5331:
5325:
5316:
5315:
5314:
5309:
5297:
5296:
5295:
5290:
5280:
5279:
5278:
5273:
5268:
5257:
5255:
5248:
5242:
5241:
5238:
5237:
5234:
5233:
5231:
5230:
5225:
5220:
5215:
5214:
5213:
5203:
5197:
5195:
5189:
5188:
5186:
5185:
5180:
5175:
5170:
5165:
5160:
5154:
5152:
5143:
5139:
5138:
5136:
5135:
5130:
5125:
5124:
5123:
5118:
5113:
5108:
5103:
5098:
5088:
5082:
5080:
5073:
5067:
5066:
5063:Nervous tissue
5059:
5058:
5051:
5044:
5036:
5030:
5029:
5017:
5016:External links
5014:
5011:
5010:
4956:
4907:
4888:(3): 397–409.
4872:
4861:
4841:
4798:
4780:
4762:
4733:
4706:
4679:
4654:
4597:
4586:on 26 May 2011
4576:Medcyclopaedia
4563:
4522:
4499:
4473:
4424:
4373:
4324:
4302:
4271:
4264:
4246:
4197:
4156:
4091:
4040:
4003:(9): 2408–19.
3983:
3934:
3905:(6): 1081–91.
3885:
3836:
3793:
3754:(11): e26832.
3734:
3727:
3709:
3660:
3617:
3596:10.1038/nn1442
3571:
3528:
3485:
3436:
3393:
3372:
3345:(3): 194–205.
3326:
3297:(3): 499–508.
3277:
3248:(4): 1507–16.
3228:
3185:
3149:
3142:
3124:
3065:
3056:
3047:
2996:
2967:(3): 437–450.
2944:
2888:
2829:
2822:
2796:
2747:
2740:
2719:
2712:
2679:
2617:
2563:
2514:
2456:
2413:
2364:
2313:
2262:
2235:(2): 555–602.
2203:
2149:
2142:
2119:
2070:
2015:
2014:
2012:
2009:
2008:
2007:
2002:
1997:
1992:
1987:
1982:
1975:
1972:
1971:
1970:
1967:
1960:
1956:
1953:
1937:jet propulsion
1929:model organism
1916:
1913:
1884:Herbert Gasser
1851:
1848:
1835:
1832:
1792:, and also in
1786:Dysmyelination
1707:
1704:
1701:
1700:
1697:
1694:
1691:
1688:
1682:
1681:
1678:
1675:
1672:
1669:
1663:
1662:
1657:
1654:
1649:
1648:Classification
1644:
1627:
1624:
1621:
1620:
1618:
1605:
1602:
1599:
1596:
1591:
1587:
1586:
1583:
1581:
1562:
1559:
1556:
1553:
1548:
1544:
1543:
1540:
1532:muscle spindle
1528:
1525:
1522:
1519:
1516:
1510:
1509:
1504:
1501:
1498:
1495:
1492:
1488:
1487:
1485:
1483:
1480:
1477:muscle spindle
1473:
1470:
1467:
1464:
1461:
1455:
1454:
1449:
1448:Mechanoceptors
1446:
1445:Proprioceptors
1443:
1437:
1436:velocity (m/s)
1432:
1429:
1424:
1423:Classification
1419:
1395:Proprioceptors
1386:
1379:
1376:
1375:
1370:
1367:
1364:
1361:
1358:
1352:
1351:
1349:
1347:
1345:
1343:
1340:
1334:
1333:
1328:
1325:
1322:
1319:
1316:
1310:
1309:
1303:
1298:
1295:
1290:
1289:Classification
1285:
1272:
1269:
1193:
1192:Classification
1190:
1185:motor proteins
1179:
1176:
1131:assist in the
1098:immunoglobulin
1050:Main article:
1047:
1044:
1026:
1023:
1006:
1003:
980:neurotrophin-3
951:
948:
926:
923:
921:
918:
852:all-or-nothing
815:Main article:
812:
809:
787:
784:
752:Main article:
749:
748:Axon terminals
746:
723:Main article:
720:
717:
652:
649:
637:motor proteins
614:neurofilaments
597:Main article:
594:
591:
571:nerve impulses
547:
544:
519:
516:
512:neurofilaments
491:
488:
366:nervous system
343:
336:
331:
326:
319:
314:
309:
304:
299:
294:
288:
287:
286:
285:
283:
280:
140:away from the
101:
100:
91:
85:
84:
79:
73:
72:
67:
61:
60:
56:
55:
52:
44:
43:
26:
9:
6:
4:
3:
2:
5885:
5874:
5871:
5870:
5868:
5849:
5846:
5844:
5841:
5839:
5836:
5834:
5831:
5829:
5826:
5824:
5821:
5819:
5816:
5814:
5811:
5809:
5806:
5804:
5801:
5799:
5796:
5795:
5793:
5791:
5787:
5781:
5778:
5776:
5773:
5771:
5768:
5764:
5761:
5759:
5756:
5754:
5751:
5750:
5749:
5746:
5744:
5740:
5737:
5736:
5734:
5732:
5728:
5725:
5721:
5709:
5708:γ motorneuron
5706:
5704:
5703:β motorneuron
5701:
5699:
5698:α motorneuron
5696:
5695:
5694:
5691:
5689:
5686:
5684:
5681:
5679:
5676:
5674:
5671:
5670:
5668:
5666:
5661:
5657:
5649:
5646:
5644:
5641:
5639:
5636:
5634:
5631:
5629:
5626:
5625:
5624:
5621:
5619:
5616:
5614:
5611:
5609:
5606:
5604:
5601:
5600:
5598:
5596:
5591:
5587:
5579:
5576:
5575:
5574:
5571:
5569:
5566:
5564:
5561:
5559:
5556:
5554:
5551:
5550:
5548:
5544:
5532:
5528:
5525:
5523:
5520:
5518:
5515:
5514:
5513:
5512:
5510:
5508:
5504:
5498:
5495:
5493:
5490:
5488:
5485:
5483:
5480:
5478:
5475:
5474:
5472:
5470:
5466:
5460:
5457:
5456:
5454:
5452:
5448:
5445:
5441:
5438:
5436:
5431:
5427:
5417:
5414:
5410:
5407:
5405:
5402:
5400:
5397:
5395:
5392:
5391:
5390:
5386:
5383:
5382:
5380:
5378:
5374:
5368:
5365:
5363:
5360:
5358:
5355:
5354:
5352:
5350:
5346:
5340:
5337:
5335:
5332:
5329:
5326:
5324:
5320:
5317:
5313:
5310:
5308:
5305:
5304:
5303:
5302:
5298:
5294:
5291:
5289:
5286:
5285:
5284:
5281:
5277:
5274:
5272:
5269:
5267:
5264:
5263:
5262:
5259:
5258:
5256:
5252:
5249:
5247:
5243:
5229:
5226:
5224:
5221:
5219:
5216:
5212:
5209:
5208:
5207:
5204:
5202:
5199:
5198:
5196:
5194:
5190:
5184:
5181:
5179:
5176:
5174:
5171:
5169:
5166:
5164:
5161:
5159:
5156:
5155:
5153:
5151:
5147:
5144:
5140:
5134:
5131:
5129:
5126:
5122:
5119:
5117:
5114:
5112:
5109:
5107:
5104:
5102:
5099:
5097:
5094:
5093:
5092:
5089:
5087:
5084:
5083:
5081:
5077:
5074:
5072:
5068:
5064:
5057:
5052:
5050:
5045:
5043:
5038:
5037:
5034:
5027:
5023:
5020:
5019:
5006:
5002:
4997:
4992:
4987:
4982:
4978:
4974:
4970:
4963:
4961:
4952:
4948:
4943:
4938:
4934:
4930:
4926:
4922:
4918:
4917:"Myelination"
4911:
4903:
4899:
4895:
4891:
4887:
4883:
4876:
4868:
4864:
4862:9781610693387
4858:
4854:
4853:
4845:
4837:
4833:
4829:
4825:
4821:
4817:
4814:(4): 341–57.
4813:
4809:
4802:
4795:
4791:
4787:
4783:
4781:9780195146943
4777:
4773:
4766:
4751:
4747:
4743:
4742:"nerve fiber"
4737:
4722:
4721:
4716:
4715:"nerve fiber"
4710:
4695:
4694:
4689:
4688:"nerve fibre"
4683:
4668:
4664:
4663:"nerve fiber"
4658:
4650:
4646:
4641:
4636:
4632:
4628:
4624:
4620:
4616:
4612:
4608:
4601:
4585:
4581:
4577:
4573:
4567:
4559:
4555:
4550:
4545:
4542:(4): 557–63.
4541:
4537:
4533:
4526:
4518:
4514:
4510:
4506:
4502:
4496:
4492:
4488:
4484:
4477:
4469:
4465:
4460:
4455:
4451:
4447:
4443:
4439:
4435:
4428:
4420:
4416:
4411:
4406:
4401:
4396:
4392:
4388:
4384:
4377:
4369:
4365:
4360:
4355:
4351:
4347:
4344:(1): 245–67.
4343:
4339:
4335:
4328:
4322:
4318:
4314:
4311:
4306:
4290:
4286:
4282:
4275:
4267:
4261:
4257:
4250:
4242:
4238:
4233:
4228:
4224:
4220:
4216:
4212:
4208:
4201:
4193:
4189:
4184:
4179:
4176:(2): 213–25.
4175:
4171:
4167:
4160:
4152:
4148:
4144:
4140:
4136:
4132:
4128:
4124:
4119:
4114:
4110:
4106:
4102:
4095:
4087:
4083:
4078:
4073:
4068:
4063:
4059:
4055:
4051:
4044:
4036:
4032:
4027:
4022:
4018:
4014:
4010:
4006:
4002:
3998:
3994:
3987:
3979:
3975:
3970:
3965:
3961:
3957:
3954:(6): 608–16.
3953:
3949:
3945:
3938:
3930:
3926:
3921:
3916:
3912:
3908:
3904:
3900:
3896:
3889:
3881:
3877:
3872:
3867:
3863:
3859:
3855:
3851:
3847:
3840:
3832:
3828:
3824:
3820:
3816:
3812:
3809:(1): 118–24.
3808:
3804:
3797:
3789:
3785:
3780:
3775:
3770:
3765:
3761:
3757:
3753:
3749:
3745:
3738:
3730:
3728:9780815344643
3724:
3720:
3713:
3705:
3701:
3697:
3693:
3688:
3683:
3680:(1): 157–70.
3679:
3675:
3671:
3664:
3656:
3652:
3648:
3644:
3640:
3636:
3632:
3628:
3621:
3613:
3609:
3605:
3601:
3597:
3593:
3590:(5): 606–15.
3589:
3585:
3578:
3576:
3567:
3563:
3559:
3555:
3551:
3547:
3543:
3539:
3532:
3524:
3520:
3516:
3512:
3508:
3504:
3500:
3496:
3489:
3481:
3477:
3473:
3469:
3464:
3459:
3456:(7): 927–41.
3455:
3451:
3447:
3440:
3432:
3428:
3424:
3420:
3416:
3412:
3409:(3): 409–24.
3408:
3404:
3397:
3391:
3390:
3385:
3381:
3376:
3368:
3364:
3360:
3356:
3352:
3348:
3344:
3340:
3333:
3331:
3322:
3318:
3313:
3308:
3304:
3300:
3296:
3292:
3288:
3281:
3273:
3269:
3264:
3259:
3255:
3251:
3247:
3243:
3239:
3232:
3224:
3220:
3216:
3212:
3208:
3204:
3200:
3196:
3189:
3181:
3177:
3173:
3169:
3166:(2): 446–54.
3165:
3161:
3153:
3145:
3139:
3135:
3128:
3120:
3116:
3111:
3106:
3101:
3096:
3092:
3088:
3085:(7): e11868.
3084:
3080:
3076:
3069:
3060:
3051:
3043:
3039:
3034:
3029:
3024:
3019:
3015:
3011:
3007:
3000:
2992:
2988:
2983:
2978:
2974:
2970:
2966:
2962:
2958:
2951:
2949:
2940:
2936:
2931:
2926:
2921:
2916:
2912:
2908:
2904:
2901:Gu C (2021).
2897:
2895:
2893:
2884:
2880:
2876:
2872:
2868:
2864:
2860:
2856:
2852:
2848:
2844:
2840:
2833:
2825:
2819:
2815:
2810:
2809:
2800:
2792:
2788:
2783:
2778:
2774:
2770:
2766:
2762:
2758:
2751:
2743:
2737:
2733:
2726:
2724:
2715:
2709:
2705:
2701:
2700:
2692:
2690:
2688:
2686:
2684:
2675:
2671:
2667:
2663:
2658:
2653:
2648:
2643:
2640:(2): 99–104.
2639:
2635:
2631:
2624:
2622:
2613:
2609:
2604:
2599:
2594:
2589:
2585:
2581:
2577:
2570:
2568:
2559:
2555:
2550:
2545:
2541:
2537:
2534:(6): 651–68.
2533:
2529:
2525:
2518:
2510:
2506:
2501:
2496:
2491:
2486:
2482:
2478:
2474:
2467:
2465:
2463:
2461:
2452:
2448:
2444:
2440:
2436:
2432:
2429:(8): 552–62.
2428:
2424:
2417:
2409:
2405:
2400:
2395:
2391:
2387:
2383:
2379:
2375:
2368:
2360:
2356:
2351:
2346:
2341:
2336:
2332:
2328:
2324:
2317:
2309:
2305:
2300:
2295:
2290:
2285:
2281:
2277:
2273:
2266:
2258:
2254:
2250:
2246:
2242:
2238:
2234:
2230:
2223:
2216:
2214:
2212:
2210:
2208:
2199:
2195:
2190:
2185:
2181:
2177:
2173:
2169:
2165:
2158:
2156:
2154:
2145:
2139:
2135:
2128:
2126:
2124:
2115:
2111:
2106:
2101:
2097:
2093:
2090:(3): 513–38.
2089:
2085:
2081:
2074:
2066:
2062:
2057:
2052:
2047:
2042:
2038:
2034:
2030:
2023:
2021:
2016:
2006:
2003:
2001:
1998:
1996:
1993:
1991:
1988:
1986:
1983:
1981:
1978:
1977:
1964:
1959:
1958:
1952:
1948:
1946:
1942:
1938:
1934:
1930:
1926:
1922:
1921:invertebrates
1919:The axons in
1915:Other animals
1912:
1910:
1905:
1901:
1897:
1896:Andrew Huxley
1893:
1889:
1885:
1881:
1877:
1873:
1869:
1865:
1861:
1857:
1847:
1845:
1841:
1831:
1829:
1825:
1821:
1816:
1814:
1810:
1806:
1802:
1797:
1795:
1794:schizophrenia
1791:
1787:
1783:
1781:
1777:
1773:
1771:
1767:
1763:
1758:
1753:
1751:
1747:
1743:
1739:
1735:
1731:
1727:
1721:
1717:
1713:
1698:
1695:
1692:
1689:
1687:
1684:
1683:
1679:
1676:
1673:
1670:
1668:
1665:
1664:
1658:
1655:
1650:
1645:
1642:
1641:
1635:
1633:
1619:
1617:
1613:
1609:
1606:
1603:
1600:
1597:
1595:
1592:
1589:
1588:
1580:
1575:
1571:
1566:
1563:
1560:
1557:
1554:
1552:
1549:
1546:
1545:
1539:
1533:
1529:
1526:
1523:
1520:
1517:
1515:
1512:
1511:
1508:
1505:
1502:
1499:
1496:
1493:
1490:
1489:
1478:
1474:
1471:
1468:
1465:
1462:
1460:
1457:
1456:
1450:
1447:
1444:
1442:
1438:
1433:
1430:
1425:
1420:
1417:
1416:
1410:
1408:
1404:
1400:
1396:
1392:
1374:
1371:
1368:
1365:
1362:
1359:
1357:
1354:
1353:
1350:
1348:
1346:
1344:
1341:
1339:
1336:
1335:
1332:
1329:
1326:
1323:
1320:
1317:
1315:
1312:
1311:
1308:
1307:muscle fibers
1304:
1299:
1296:
1291:
1286:
1283:
1282:
1276:
1268:
1264:
1262:
1258:
1254:
1250:
1246:
1245:motor neurons
1242:
1238:
1234:
1230:
1226:
1221:
1218:
1214:
1210:
1205:
1199:
1189:
1186:
1175:
1173:
1172:neurotoxicity
1169:
1165:
1160:
1156:
1154:
1150:
1144:
1142:
1138:
1137:axon guidance
1134:
1130:
1127:Cells called
1125:
1123:
1119:
1115:
1111:
1107:
1103:
1099:
1095:
1091:
1087:
1083:
1079:
1075:
1071:
1070:lamellipodium
1067:
1058:
1053:
1052:Axon guidance
1043:
1041:
1040:Rho-signaling
1036:
1032:
1022:
1020:
1016:
1012:
1002:
1000:
996:
992:
987:
985:
984:Trk receptors
981:
977:
973:
969:
965:
961:
957:
947:
945:
940:
936:
932:
917:
915:
911:
907:
901:
898:
897:digital codes
893:
891:
887:
882:
878:
874:
868:
866:
862:
856:
853:
843:
837:
833:
828:
824:
823:Neural coding
818:
808:
806:
802:
797:
793:
783:
781:
777:
773:
769:
765:
764:axon terminal
761:
755:
754:Axon terminal
745:
743:
739:
735:
731:
726:
716:
714:
710:
705:
703:
699:
698:Schwann cells
695:
690:
688:
681:
677:
676:Myelin sheath
673:
668:
661:
657:
648:
646:
642:
638:
634:
630:
626:
622:
617:
615:
610:
606:
600:
590:
588:
584:
580:
576:
572:
567:
563:
561:
557:
556:cell polarity
553:
543:
541:
537:
533:
524:
515:
513:
509:
505:
501:
497:
490:Axonal region
487:
483:
481:
477:
473:
469:
465:
461:
457:
453:
449:
444:
442:
438:
434:
430:
426:
425:Schwann cells
422:
418:
414:
410:
405:
403:
399:
395:
391:
387:
383:
379:
375:
374:sciatic nerve
371:
367:
360:
356:
351:
339:
338:Myelin sheath
334:
329:
328:Axon terminal
324:
317:
312:
307:
302:
297:
292:
279:
277:
273:
269:
265:
261:
257:
253:
249:
244:
242:
237:
233:
229:
225:
221:
220:axon terminal
217:
213:
209:
204:
202:
198:
193:
191:
187:
183:
179:
175:
171:
167:
163:
159:
155:
151:
147:
143:
139:
135:
131:
127:
123:
120:
116:
112:
108:
96:
90:
86:
83:
80:
78:
74:
71:
68:
66:
62:
57:
50:
45:
40:
37:
33:
19:
5743:Gap junction
5665:Motor neuron
5468:
5459:Axon hillock
5435:nerve fibers
5389:Schwann cell
5299:
5282:
5260:
5178:Medium spiny
5091:White matter
5079:Tissue Types
4976:
4972:
4924:
4920:
4910:
4885:
4881:
4875:
4855:. ABC-CLIO.
4851:
4844:
4811:
4807:
4801:
4793:
4771:
4765:
4753:. Retrieved
4745:
4736:
4724:. Retrieved
4718:
4709:
4697:. Retrieved
4691:
4682:
4670:. Retrieved
4666:
4657:
4617:(1): 14626.
4614:
4610:
4600:
4588:. Retrieved
4584:the original
4575:
4566:
4539:
4535:
4525:
4482:
4476:
4441:
4437:
4427:
4390:
4387:PLOS Biology
4386:
4376:
4341:
4337:
4327:
4305:
4293:. Retrieved
4284:
4274:
4255:
4249:
4214:
4210:
4200:
4173:
4169:
4159:
4108:
4104:
4094:
4057:
4053:
4043:
4000:
3996:
3986:
3951:
3948:Cell Reports
3947:
3937:
3902:
3898:
3888:
3853:
3849:
3839:
3806:
3802:
3796:
3751:
3747:
3737:
3718:
3712:
3677:
3673:
3663:
3630:
3626:
3620:
3587:
3583:
3541:
3537:
3531:
3501:(1): 61–85.
3498:
3494:
3488:
3453:
3449:
3439:
3406:
3402:
3396:
3388:
3375:
3342:
3338:
3294:
3290:
3280:
3245:
3241:
3231:
3201:(5): 544–6.
3198:
3194:
3188:
3163:
3159:
3152:
3133:
3127:
3082:
3078:
3068:
3059:
3050:
3016:(181): 181.
3013:
3009:
2999:
2964:
2961:Brain Pathol
2960:
2910:
2906:
2842:
2841:. Series B.
2838:
2832:
2807:
2799:
2764:
2760:
2750:
2731:
2698:
2637:
2633:
2583:
2579:
2531:
2527:
2517:
2480:
2476:
2426:
2422:
2416:
2381:
2377:
2367:
2330:
2326:
2316:
2279:
2275:
2265:
2232:
2228:
2171:
2167:
2133:
2087:
2083:
2073:
2036:
2032:
2000:Pioneer axon
1949:
1918:
1909:ion channels
1892:Alan Hodgkin
1864:Robert Remak
1853:
1837:
1828:nerve injury
1817:
1798:
1784:
1774:
1754:
1723:
1712:Nerve injury
1638:Fiber types
1629:
1388:
1274:
1265:
1222:
1208:
1201:
1181:
1157:
1145:
1126:
1090:glycoprotein
1063:
1028:
1019:phosphatases
1008:
988:
953:
944:cytoskeletal
928:
912:and shorter
902:
894:
890:interneurons
888:(~500μs) or
869:
857:
848:
791:
789:
759:
757:
733:
728:
706:
691:
684:
672:Schwann cell
625:mitochondria
618:
602:
568:
564:
551:
549:
532:axon hillock
529:
518:Axon hillock
504:microtubules
496:Nissl bodies
493:
484:
471:
468:nerve tracts
452:white matter
445:
413:unmyelinated
406:
363:
359:white matter
333:Schwann cell
311:Axon hillock
305:
268:white matter
266:the largest
245:
240:
205:
194:
121:
118:
114:
110:
106:
104:
36:
5758:Active zone
5723:Termination
5573:Interneuron
5477:Telodendron
5385:Myelination
5367:Endoneurium
5362:Perineurium
5183:Interneuron
5173:Von Economo
5121:Decussation
5116:Nerve tract
5086:Grey matter
5026:Spinal cord
2483:: 6808293.
1933:giant squid
1904:Nobel Prize
1888:myelination
1862:and German
1834:Terminology
1734:neurotmesis
1730:axonotmesis
1726:neurapraxia
1608:Nociceptors
1570:Nociceptors
1439:Associated
1403:nociceptors
1305:Associated
1164:macrophages
1114:fibronectin
1066:growth cone
991:ganglioside
978:(BDNF) and
935:hippocampal
925:Development
881:gray matter
873:place cells
827:Active zone
796:hippocampus
760:telodendron
694:glial cells
651:Myelination
472:commissures
460:grey matter
421:glial cells
378:spinal cord
355:grey matter
276:human brain
248:nerve tract
216:telodendria
197:cytoplasmic
134:vertebrates
115:nerve fiber
113:, axis) or
59:Identifiers
18:Nerve fiber
5828:Nociceptor
5568:Multipolar
5517:Nissl body
5394:Neurilemma
5357:Epineurium
5142:Cell Types
4217:: 347–60.
4118:1807.04799
3544:: 609–42.
3389:C. elegans
2913:: 610857.
2011:References
1738:Concussion
1659:Conduction
1434:Conduction
1389:Different
1143:required.
946:dynamics.
865:exocytosis
687:myelinated
680:Neurilemma
464:cerebellum
409:myelinated
382:micrometer
190:myelinated
166:peripheral
5843:Hair cell
5377:Neuroglia
5339:Funiculus
5228:Microglia
5201:Astrocyte
5158:Pyramidal
5111:Lemniscus
4151:118682719
3380:Neuroglia
1844:dendrites
1799:A severe
1626:Autonomic
1241:efferents
1237:afferents
1074:filopodia
995:sialidase
910:threshold
696:known as
619:Outgoing
609:cytoplasm
587:ankyrin-G
538:that are
510:known as
431:. In the
158:periphery
5867:Category
5628:Ia or Aα
5558:Unipolar
5507:Dendrite
5492:Axolemma
5487:Axoplasm
5271:Ganglion
5211:Tanycyte
5163:Purkinje
5150:Neuronal
5133:Meninges
5128:Neuropil
5005:29170630
4951:27780071
4867:Archived
4836:37676544
4828:16997762
4790:27151391
4755:21 April
4726:21 April
4699:21 April
4672:21 April
4649:31602002
4558:17291371
4517:44405442
4509:16802706
4468:17093095
4419:20126265
4368:20345246
4313:Archived
4289:Archived
4285:Medscape
4143:31212501
4101:Morigi G
4086:26257607
4035:25954897
3978:22773964
3929:17846176
3880:19321792
3823:15018947
3788:22073205
3748:PLOS ONE
3704:28813676
3655:10082468
3612:25227765
3604:15834419
3566:10217268
3558:12676795
3523:23974242
3480:18043414
3472:10399920
3431:22666205
3367:15556921
3359:17311006
3321:12417580
3223:27728967
3215:15856056
3119:20686619
3079:PLOS ONE
3042:24348338
2991:30444552
2939:33613192
2883:11963512
2875:13003931
2791:27141942
2674:18862030
2666:26464228
2657:10717305
2612:27826229
2558:20007821
2509:27493806
2451:23996233
2443:20631711
2408:29378864
2359:28184187
2308:28536506
2257:13916255
2249:21527732
2198:20720105
2065:25477788
1974:See also
1699:0.5–2.0
1651:Diameter
1426:Diameter
1292:Diameter
1213:Erlanger
1168:Dectin-1
1133:guidance
1122:perlecan
1118:tenascin
939:neurites
605:axoplasm
296:Dendrite
256:fascicle
254:, and a
236:membrane
228:synapses
224:synaptic
212:axoplasm
208:axolemma
201:dendrite
5770:Autapse
5731:Synapse
5578:Renshaw
5553:Bipolar
5430:Neurons
5283:Ventral
5254:General
5168:Granule
4996:5684645
4979:: 332.
4929:Bibcode
4902:8807532
4640:6787341
4619:Bibcode
4590:20 June
4459:6674790
4410:2811159
4359:5223592
4295:14 July
4241:7359413
4232:1279120
4192:4482075
4123:Bibcode
4077:4508512
4060:: 281.
4026:4423051
4005:Bibcode
3969:3389498
3920:2064629
3871:2693768
3831:9672315
3779:3206876
3756:Bibcode
3696:2317872
3635:Bibcode
3627:Science
3515:2310575
3423:8062384
3312:2173080
3272:2925793
3263:2115496
3180:2583372
3110:2912328
3087:Bibcode
3033:3831546
2982:6482960
2930:7886671
2847:Bibcode
2782:4967101
2704:584–587
2603:5078684
2586:: 250.
2549:2951114
2500:4967436
2399:6596274
2350:5266712
2299:5422562
2282:: 136.
2189:3197828
2114:1018277
2105:1307715
2056:4235383
2039:: 133.
1850:History
1693:0.2–1.5
1604:0.5–2.0
1598:0.2–1.5
1383:Sensory
1233:group C
1229:group B
1225:group A
1110:laminin
1035:f-actin
974:(NGF),
780:autapse
776:synapse
641:kinesin
415:axons.
402:neurons
323:Ranvier
321:Node of
316:Nucleus
282:Anatomy
258:in the
250:in the
232:autapse
174:classed
70:D001369
5623:fibers
5261:Dorsal
5003:
4993:
4949:
4900:
4859:
4834:
4826:
4788:
4778:
4647:
4637:
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4356:
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4023:
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3966:
3927:
3917:
3878:
3868:
3829:
3821:
3786:
3776:
3725:
3702:
3694:
3653:
3610:
3602:
3564:
3556:
3521:
3513:
3495:Neuron
3478:
3470:
3429:
3421:
3365:
3357:
3319:
3309:
3270:
3260:
3221:
3213:
3178:
3140:
3117:
3107:
3040:
3030:
2989:
2979:
2937:
2927:
2881:
2873:
2865:
2820:
2789:
2779:
2738:
2710:
2672:
2664:
2654:
2610:
2600:
2556:
2546:
2507:
2497:
2449:
2441:
2406:
2396:
2357:
2347:
2306:
2296:
2255:
2247:
2196:
2186:
2140:
2112:
2102:
2063:
2053:
1770:NMNAT2
1718:, and
1656:Myelin
1503:80–120
1472:80–120
1431:Myelin
1327:80–120
1297:Myelin
1259:, and
1231:, and
1217:Gasser
1159:Nogo-A
1120:, and
1046:Growth
964:Netrin
762:is an
645:dynein
540:summed
456:tissue
417:Myelin
370:nerves
184:, and
130:neuron
124:: see
5546:Types
5443:Parts
5312:White
5293:Ramus
5276:Ramus
5193:Glial
4832:S2CID
4513:S2CID
4147:S2CID
4113:arXiv
3827:S2CID
3700:S2CID
3608:S2CID
3562:S2CID
3519:S2CID
3476:S2CID
3427:S2CID
3363:S2CID
3219:S2CID
2879:S2CID
2867:82721
2863:JSTOR
2670:S2CID
2447:S2CID
2333:: 6.
2253:S2CID
2225:(PDF)
1732:, or
1680:3–15
1577:Cold
1527:33–75
1497:13–20
1466:13–20
1321:13–20
1271:Motor
1086:TAG-1
1082:N-CAM
1031:actin
968:UNC-5
877:white
262:. In
132:, in
122:fibre
119:nerve
93:[
82:67308
5469:Axon
5451:Soma
5307:Gray
5288:Root
5266:Root
5001:PMID
4947:PMID
4898:PMID
4857:ISBN
4824:PMID
4786:OCLC
4776:ISBN
4757:2023
4728:2023
4701:2023
4674:2023
4645:PMID
4592:2018
4554:PMID
4505:PMID
4495:ISBN
4464:PMID
4415:PMID
4364:PMID
4297:2018
4260:ISBN
4237:PMID
4188:PMID
4139:PMID
4082:PMID
4031:PMID
3974:PMID
3925:PMID
3876:PMID
3819:PMID
3784:PMID
3723:ISBN
3692:PMID
3674:Cell
3651:PMID
3600:PMID
3554:PMID
3511:PMID
3468:PMID
3450:Cell
3419:PMID
3403:Cell
3382:and
3355:PMID
3317:PMID
3268:PMID
3211:PMID
3176:PMID
3138:ISBN
3115:PMID
3038:PMID
2987:PMID
2935:PMID
2871:PMID
2818:ISBN
2787:PMID
2736:ISBN
2708:ISBN
2662:PMID
2608:PMID
2554:PMID
2505:PMID
2481:2016
2439:PMID
2404:PMID
2355:PMID
2304:PMID
2245:PMID
2194:PMID
2138:ISBN
2110:PMID
2061:PMID
1894:and
1882:and
1653:(μm)
1643:Type
1630:The
1561:3–30
1558:Thin
1547:III
1536:All
1521:6–12
1428:(μm)
1418:Type
1405:and
1369:4–24
1294:(μm)
1284:Type
1215:and
1011:PI3K
999:TrkA
989:The
879:and
825:and
678:(5)
674:(4)
627:and
603:The
581:and
560:soma
550:The
530:The
506:and
427:and
411:and
357:and
306:Axon
301:Soma
168:and
117:(or
111:áxōn
107:axon
65:MeSH
42:Axon
5683:SVE
5678:GVE
5673:GSE
5618:SVA
5613:SSA
5608:GVA
5603:GSA
5246:PNS
5071:CNS
4991:PMC
4981:doi
4937:doi
4890:doi
4816:doi
4635:PMC
4627:doi
4544:doi
4487:doi
4454:PMC
4446:doi
4405:PMC
4395:doi
4354:PMC
4346:doi
4227:PMC
4219:doi
4215:298
4178:doi
4131:doi
4072:PMC
4062:doi
4021:PMC
4013:doi
4001:108
3964:PMC
3956:doi
3915:PMC
3907:doi
3903:178
3866:PMC
3858:doi
3811:doi
3774:PMC
3764:doi
3682:doi
3643:doi
3631:283
3592:doi
3546:doi
3503:doi
3458:doi
3411:doi
3347:doi
3307:PMC
3299:doi
3295:159
3258:PMC
3250:doi
3246:108
3203:doi
3168:doi
3164:136
3105:PMC
3095:doi
3028:PMC
3018:doi
2977:PMC
2969:doi
2925:PMC
2915:doi
2855:doi
2843:140
2814:300
2777:PMC
2769:doi
2652:PMC
2642:doi
2598:PMC
2588:doi
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2431:doi
2394:PMC
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2335:doi
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2184:PMC
2176:doi
2100:PMC
2092:doi
2088:263
2051:PMC
2041:doi
1813:rat
1677:Yes
1674:1–5
1610:of
1590:IV
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1555:1–5
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1500:Yes
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